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https://www.readbyqxmd.com/read/28231554/design-of-elution-strategy-for-simultaneous-detection-of-chloramphenicol-and-gentamicin-in-complex-samples-using-surface-plasmon-resonance
#1
Yinqiang Xia, Rongxin Su, Renliang Huang, Li Ding, Libing Wang, Wei Qi, Zhimin He
For the analysis of massive samples containing multiple analytes, the enhancement of detection efficiency is crucial. In this study, a facile method was developed for sequential detection of chloramphenicol (CAP) and gentamicin (GEN) in complex samples, e.g. milk, using a surface plasmon resonance (SPR)-based biosensor. Based on the immune inhibition format, two conjugates of antigen and bovine serum albumin (BSA)-denoted as CAP-BSA and GEN-BSA-were grafted on the same channel of the SPR sensor chip. Two standard curves for CAP and GEN were separately obtained by first mixing a single antibody with different concentrations of the relevant antigen...
February 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28231553/a-reusable-aptasensor-of-thrombin-based-on-dna-machine-employing-resonance-light-scattering-technique
#2
Yining Hou, Jifeng Liu, Min Hong, Xia Li, Yanhua Ma, Qiaoli Yue, Chen-Zhong Li
The design of molecular nanodevices attracted great interest in these years. Herein, a reusable, sensitive and specific aptasensor was constructed based on an extension-contraction movement of DNA interconversion for the application of human thrombin detection. The present biosensor was based on resonance light scattering (RLS) using magnetic nanoparticles (MNPs) as the RLS probe. MNPs coated with streptavidin can combine with biotin labeled thrombin aptamers. The combined nanoparticles composite is monodispersed in aqueous medium...
February 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28230868/tuning-calcium-biosensors-with-a-single-site-mutation-structural-dynamics-insights-from-femtosecond-raman-spectroscopy
#3
Sean R Tachibana, Longteng Tang, Yanli Wang, Liangdong Zhu, Weimin Liu, Chong Fang
Fluorescent protein biosensors are popular reporters for biological processes and life sciences, but their fundamental working mechanisms remain unclear. To characterize the functional fluorescence events on their native timescales, we implemented wavelength-tunable femtosecond stimulated Raman spectroscopy (FSRS) to shed light on a blue-green emission-ratiometric fluorescent protein based Ca(2+) biosensor with a single Pro377Arg mutation. The transient Raman modes of the embedded chromophore from ca. 1000-1650 cm(-1) exhibit characteristic intensity and frequency dynamics which infer the underlying atomic motions and photochemical reaction stages...
February 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28230745/toward-improving-electrocardiogram-ecg-biometric-verification-using-mobile-sensors-a-two-stage-classifier-approach
#4
Robin Tan, Marek Perkowski
Electrocardiogram (ECG) signals sensed from mobile devices pertain the potential for biometric identity recognition applicable in remote access control systems where enhanced data security is demanding. In this study, we propose a new algorithm that consists of a two-stage classifier combining random forest and wavelet distance measure through a probabilistic threshold schema, to improve the effectiveness and robustness of a biometric recognition system using ECG data acquired from a biosensor integrated into mobile devices...
February 20, 2017: Sensors
https://www.readbyqxmd.com/read/28227975/an-adaptive-deep-learning-approach-for-ppg-based-identification
#5
V Jindal, J Birjandtalab, M Baran Pouyan, M Nourani, V Jindal, J Birjandtalab, M Baran Pouyan, M Nourani, V Jindal, M Baran Pouyan, J Birjandtalab, M Nourani
Wearable biosensors have become increasingly popular in healthcare due to their capabilities for low cost and long term biosignal monitoring. This paper presents a novel two-stage technique to offer biometric identification using these biosensors through Deep Belief Networks and Restricted Boltzman Machines. Our identification approach improves robustness in current monitoring procedures within clinical, e-health and fitness environments using Photoplethysmography (PPG) signals through deep learning classification models...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227973/improving-odorant-chemical-class-prediction-with-multi-layer-perceptrons-using-temporal-odorant-spike-responses-from-drosophila-melanogaster-olfactory-receptor-neurons
#6
Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth, Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth, Charles P Unsworth, Andrew V Kralicek, Richard D Newcomb, Luqman R Bachtiar
In this work, we examine the possibility of improving the prediction performance of an olfactory biosensor through the use of temporal spiking data. We present an Artificial Neural Network (ANN), in the form of an optimal hybrid Multi-Layer Perceptron (MLP) system for the classification of chemical odorants from olfactory receptor neuron spike responses of the Drosophila melanogaster fruit fly (DmOrs). The data used in this study contains the responses to 34 odorants from 6 individual DmOrs, of which we exploit the temporal spiking responses of a 500ms odorant stimulus window...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227952/smartstuff-a-case-study-of-a-smart-water-bottle
#7
Emil Jovanov, Vindhya R Nallathimmareddygari, Jonathan E Pryor, Emil Jovanov, Vindhya R Nallathimmareddygari, Jonathan E Pryor, Vindhya R Nallathimmareddygari, Emil Jovanov, Jonathan E Pryor
The rapid growth of Internet of Things (IoT) and miniature wearable biosensors have generated new opportunities for personalized eHealth and mHealth services. Smart objects equipped with physiological sensors can provide robust monitoring of activities of daily living and context for wearable physiological sensors. We present a case study of an intelligent water bottle that can precisely measure the amount of liquid in the bottle, monitor activity using inertial sensors, and physiological parameters using a touch and photoplethysmographic sensor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227816/a-wide-range-and-high-sensitivity-four-channel-compact-electrochemical-biosensor-for-neurotransmitter-detection-on-a-microfluidic-platform
#8
Elnaz Ghodsevali, Hamza Landari, Mounir Boukadoum, Benoit Gosselin, Amine Miled, Elnaz Ghodsevali, Hamza Landari, Mounir Boukadoum, Benoit Gosselin, Amine Miled, Benoit Gosselin, Amine Miled, Elnaz Ghodsevali, Mounir Boukadoum, Hamza Landari
We present a four-channel, high-sensitivity and linearity electrochemical biosensor for neurotransmitter (NT) detection and measurement. Using a multi-channel microfluidic platform makes this biosensor capable of detecting NT-related currents going from nanoamperes to milliamperes, with a sensitivity of the order of picoamperes. Moreover, by using a fully differential potentiostat architecture, the biosensor offers a high common-mode rejection ratio (90 dB), making it appropriate for low-noise and high-sensitive applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227492/biomems-based-coding-for-secure-medical-diagnostic-devices
#9
Tuan Le, Gabriel Salles-Loustau, Laleh Najafizadeh, Mehdi Javanmard, Saman Zonouz, Tuan Le, Gabriel Salles-Loustau, Laleh Najafizadeh, Mehdi Javanmard, Saman Zonouz, Saman Zonouz, Gabriel Salles-Loustau, Laleh Najafizadeh, Tuan Le, Mehdi Javanmard
Trustworthy and usable point-of-care solutions require not only effective disease diagnostic procedures to ensure delivery of rapid and accurate outcomes, but also lightweight privacy-preserving capabilities. In this paper, we present a Biomedical Microelectromachanical System (BioMEMS)-based sensor for portable, inexpensive smartphone-based biomarker detection. The biosensor presented here provides the ability for signal encryption at the physical sensor level to ensure patient's diagnostic confidentiality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227475/label-free-detection-of-sex-determining-region-y-sry-via-capacitive-biosensor
#10
Shilpa Sivashankar, Christos Sapsanis, Sumeyra Agambayev, Ulrich Buttner, Khaled Nabil Salama, Shilpa Sivashankar, Christos Sapsanis, Sumeyra Agambayev, Ulrich Buttner, Khaled Nabil Salama, Khaled Nabil Salama, Shilpa Sivashankar, Sumeyra Agambayev, Christos Sapsanis, Ulrich Buttner
In this work, we present for the first time, the use of a simple fractal capacitive biosensor for the quantification and detection of sex-determining region Y (SRY) genes. This section of genetic code, which is found on the Y chromosome, finds importance for study as it causes fetuses to develop characteristics of male sex-like gonads when a mutation occurs. It is also an important genetic code in men, and disorders involving the SRY gene can cause infertility and sexual malfunction that lead to a variety of gene mutational disorders...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227160/on-the-capacity-of-diffusion-based-molecular-communications-with-sinw-fet-based-receiver
#11
Murat Kuscu, Ozgur B Akan, Murat Kuscu, Ozgur B Akan, Ozgur B Akan, Murat Kuscu
Molecular communication (MC) is a bio-inspired communication method based on the exchange of molecules for information transfer among nanoscale devices. Although MC has been extensively studied from various aspects, limitations imposed by the physical design of transceiving units have been largely neglected in the literature. Recently, we have proposed a nanobioelectronic MC receiver architecture based on the nanoscale field effect transistor-based biosensor (bioFET) technology, providing noninvasive and sensitive molecular detection at nanoscale while producing electrical signals at the output...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227146/power-management-design-for-lab-on-chip-biosensors
#12
Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Jie Chen, Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Jie Chen, Kambiz Moez, Xiaojian Yu, I-Chyn Wey, Jie Chen
Over the past decades, we have witnessed the growth demands of portable lab-on-chip biosensors. These lab-on-chip devices are mostly powered by battery, and intelligent power management systems are required to provide supply voltage for different functional units on biosensors (e.g. a microfluidic control system might require higher voltage than the rest working units of biosensors). In this paper, a fully integrated multiple-stage voltage multiplier is proposed to provide high-voltage power needs. The proposed design was implemented with the IBM's 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227145/towards-an-implantable-bio-sensor-platform-for-continuous-real-time-monitoring-of-anti-epileptic-drugs
#13
Abbas Hammoud, Ahmad Chamseddine, Dang K Nguyen, Mohamad Sawan, Abbas Hammoud, Ahmad Chamseddine, Dang K Nguyen, Mohamad Sawan, Mohamad Sawan, Abbas Hammoud, Dang K Nguyen
The need of continuous real-time monitoring device for in-vivo drug level detection has been widely articulated lately. Such monitoring could guide drug posology and timing of intake, detect low or high drug levels, in order to take adequate measures, and give clinicians a valuable window into patients' health and their response to therapeutics. This paper presents a novel implantable bio-sensor based on impedance measurement capable of continuously monitoring various antiepileptic drug levels. This portable point-of-care microsystem replaces large and stationary conventional macrosystems, and is a one of a kind system designed with an array of electrodes to monitor various anti-epileptic drugs rather than one drug...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226932/novel-refractive-index-biosensing-of-microcontact-printed-molecules-on-lithium-niobate
#14
Nikhil Bhalla, Shivani Sathish, Amy Q Shen, Nikhil Bhalla, Shivani Sathish, Amy Q Shen, Shivani Sathish, Amy Q Shen, Nikhil Bhalla
This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226930/highly-sensitive-detection-of-human-cancer-antigens-by-an-immunogold-silver-assay-chip-coupled-with-a-polythiophene-based-optical-sensor
#15
Nuno M M Pires, Tao Dong, Nuno M M Pires, Tao Dong, Nuno M M Pires, Tao Dong
This work presents a novel method for protein or cancer antigen detection in clinical samples by an immunogold-silver assay microfluidic biochip coupled with a polythiophene-based organic photodetector. The method has showed a detection limit below 1ng/mL and the low cost and high sensitivity of both organic photodetector and immunogold-silver assay make this method amenable for realization in a portable handheld probe tip biosensor.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226890/stability-of-the-microdroplets-for-portable-biosensor
#16
Yusuke Izawa, Toshihisa Osaki, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Yusuke Izawa, Toshihisa Osaki, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Yusuke Izawa, Toshihisa Osaki
This paper highlights the behavior of microdroplets used for portable biosensors. Microdroplets have been applied for various Lab-on-a-chip applications, in which portability/wearable is becoming a trend word. However, the resonance (sloshing phenomena) of the microdroplets could be an issue. For example, bilayer lipid membrane, fragile characteristics due to its thickness of 5 nm, easily ruptures by jiggling. We therefore prepared various dimensions of droplets by changing the well shape, and examined the resulting waves depending on the vibration frequency between 20 and 100 Hz, including daily life frequencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226497/simulations-and-design-of-microfabricated-interdigitated-electrodes-for-use-in-a-gold-nanoparticle-enhanced-biosensor
#17
Peter Hermansen, Scott MacKay, David Wishart, Jie Chen, Peter Hermansen, Scott MacKay, David Wishart, Jie Chen, David Wishart, Peter Hermansen, Scott MacKay, Jie Chen
Microfabricated interdigitated electrode chips have been designed for use in a unique gold-nanoparticle based biosensor system. The use of these electrodes will allow for simple, accurate, inexpensive, and portable biosensing, with potential applications in diagnostics, medical research, and environmental testing. To determine the optimal design for these electrodes, finite element analysis simulations were carried out using COMSOL Multiphysics software. The results of these simulations determined some of the optimal design parameters for microfabricating interdigitated electrodes as well as predicting the effects of different electrode materials...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226496/nano-fabricated-memristive-biosensors-for-biomedical-applications-with-liquid-and-dried-samples
#18
I Tzouvadaki, X Lu, G De Micheli, S Ingebrandt, S Carrara, I Tzouvadaki, X Lu, G De Micheli, S Ingebrandt, S Carrara, I Tzouvadaki, X Lu, S Ingebrandt, G De Micheli, S Carrara
Nanowire based platforms are widely reported for sensing applications and for their potential in the bio-detection field. In the present work, memristive nanowire devices are implemented for label-free sensing in liquid samples as well as in dried samples via leveraging the modification of the hysteresis in the devices electrical response as a consequence of the surface modification. First, pH sensing in liquid conditions is demonstrated. In addition, the memristive devices are bio-functionalized using antibodies for Prostate Specific Antigen (PSA) as case of study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226280/development-of-electrochemical-biosensor-for-detection-of-pathogenic-microorganism-in-asian-dust-events
#19
Min-Sang Yoo, Minguk Shin, Younghun Kim, Min Jang, Yoon-E Choi, Si Jae Park, Jonghoon Choi, Jinyoung Lee, Chulhwan Park
We developed a single-walled carbon nanotubes (SWCNTs)-based electrochemical biosensor for the detection of Bacillus subtilis, one of the microorganisms observed in Asian dust events, which causes respiratory diseases such as asthma and pneumonia. SWCNTs plays the role of a transducer in biological antigen/antibody reaction for the electrical signal while 1-pyrenebutanoic acid succinimidyl ester (1-PBSE) and ant-B. subtilis were performed as a chemical linker and an acceptor, respectively, for the adhesion of target microorganism in the developed biosensor...
February 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28226234/zooming-in-on-plant-hormone-analysis-tissue-and-cell-specific-approaches
#20
Ondřej Novák, Richard Napier, Karin Ljung
Plant hormones are a group of naturally occurring, low-abundance organic compounds that influence physiological processes in plants. Our knowledge of the distribution profiles of phytohormones in plant organs, tissues, and cells is still incomplete, but advances in mass spectrometry have enabled significant advances in tissue- and cell-type-specific analyses of phytohormones over the last decade. Mass spectrometry is able to simultaneously identify and quantify hormones and their related substances. Biosensors, on the other hand, offer continuous monitoring; can visualize local distributions and realtime quantification; and, in the case of genetically encoded biosensors, are noninvasive...
February 10, 2017: Annual Review of Plant Biology
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