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Muscle skeletal research

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https://www.readbyqxmd.com/read/29351416/acute-and-chronic-resistance-training-downregulates-select-line-1-retrotransposon-activity-markers-in-human-skeletal-muscle
#1
Matthew A Romero, C Brooks Mobley, Petey W Mumford, Paul A Roberson, Cody T Haun, Wesley C Kephart, James C Healy, Darren T Beck, Kaelin C Young, Jeffrey S Martin, Christopher M Lockwood, Michael D Roberts
Herein, we examined if acute or chronic resistance exercise affected markers of skeletal muscle LINE-1 retrotransposon activity. In study 1, 10 resistance-trained college-aged males performed three consecutive daily back squat sessions, and vastus lateralis biopsies were taken prior to (Pre), 2 h following session 1 (Post1), and 3 days following session 3 (Post2). In study 2, 13 untrained college-aged males performed a full-body resistance training program (3 d/wk), and vastus lateralis biopsies were taken prior to (week 0) and ~72 h following training cessation (week 12)...
December 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29349700/adrenergic-and-metabolic-effects-of-electrical-weapons-review-and-meta-analysis-of-human-data
#2
REVIEW
S N Kunz, H G Calkins, J Adamec, M W Kroll
INTRODUCTION: Electronic control with the CEW (conducted electrical weapon) has gained widespread acceptance as the preferred force option due to its significant injury reduction. However, a CEW application does stress the human body. In the case of the CEW, the human body response is similar to the challenge of physical exercise combined with emotional stress over a very short time interval. There has been concern whether the tension of the skeletal-muscle system together with the emotional stress of being exposed to the effects of a CEW, can lead to severe metabolic dysfunction...
January 19, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29344670/pgc-1%C3%AE-ameliorates-kidney-fibrosis-in-mice-with-diabetic-kidney-disease-through-an-antioxidative-mechanism
#3
Liwen Zhang, Jian Liu, Fangfang Zhou, Weiming Wang, Nan Chen
The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α) participates in mitochondrial biogenesis and energy metabolism in certain mitochondria‑enriched cells, including myocardial and skeletal muscle cells. Therefore, we hypothesized that PGC‑1α may be a protective nuclear factor against energy and oxidative stress in DKD...
January 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29343219/the-preliminary-effect-of-whole-body-vibration-intervention-on-improving-the-skeletal-muscle-mass-index-physical-fitness-and-quality-of-life-among-older-people-with-sarcopenia
#4
Shu-Fang Chang, Pei-Chen Lin, Rong-Sen Yang, Rea-Jeng Yang
BACKGROUND: Studies have shown that sarcopenia easily leads to difficulty moving, disability, and poor quality of life. However, researches on the use of whole-body vibration for older adults with sarcopenia living in institutions have been lacking. Therefore, the main objective of the present study was to investigate the effect of whole-body vibration intervention on improving the skeletal muscle mass index, physical fitness, and quality of life of older adults with sarcopenia living in institutions...
January 17, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29338383/the-process-of-engraftment-of-myogenic-cells-in-skeletal-muscles-of-primates-understanding-clinical-observations-and-setting-directions-in-cell-transplantation-research
#5
Daniel Skuk, Jacques P Tremblay
We studied in macaques the evolution of the intramuscular transplantation of muscle precursor cells between the time of administration and the time at which the graft is considered stable. Satellite cell-derived myoblasts labeled with ß-galactosidase were transplanted into 1 cm3 muscle regions following cell culture and transplantation protocols similar to our last clinical trials. These regions were biopsied 1 h, 1, 3, 7 d, and 3 wk later and analyzed by histology. We observed that the cell suspension leaks from the muscle bundles during injection toward the epimysium and perimysium, where most cells accumulate after transplantation...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29333754/a-guide-to-analysis-and-reconstruction-of-serial-block-face-scanning-electron-microscopy-data
#6
E Cocks, M Taggart, F C Rind, K White
Serial block face scanning electron microscopy (SBF-SEM) is a relatively new technique that allows the acquisition of serially sectioned, imaged and digitally aligned ultrastructural data. There is a wealth of information that can be obtained from the resulting image stacks but this presents a new challenge for researchers - how to computationally analyse and make best use of the large datasets produced. One approach is to reconstruct structures and features of interest in 3D. However, the software programmes can appear overwhelming, time-consuming and not intuitive for those new to image analysis...
January 15, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29331586/positive-effects-of-total-recovery-period-on-anti-and-pro-inflammatory-cytokines-are-not-linked-to-performance-re-establishment-in-overtrained-mice
#7
Alisson L da Rocha, Ana P Pinto, Bruno C Pereira, Eike B Kohama, Gustavo P Morais, Larissa G de Vicente, José R Pauli, Dennys E Cintra, Eduardo R Ropelle, Leandro P de Moura, Hugo T Filho, Adelino S R da Silva
The association between excessive training sessions (i.e., overtraining/OT) and periods of inadequate recovery is linked to the nonfunctional overreaching (NFOR) state, which is defined as an unexplained decrement or stagnation of performance. The cytokine hypothesis of OT considers that pro-inflammatory cytokines are responsible by the NFOR state-induced performance decrement. Investigations using rodent models of OT verified increased levels of pro-inflammatory cytokines in hypothalamus, liver, serum and skeletal muscle samples...
January 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29330356/metabolic-and-molecular-changes-associated-with-the-increased-skeletal-muscle-insulin-action-24-48%C3%A2-h-after-exercise-in-young-and-old-humans
#8
REVIEW
Francis B Stephens, Kostas Tsintzas
The molecular and metabolic mechanisms underlying the increase in insulin sensitivity (i.e. increased insulin-stimulated skeletal muscle glucose uptake, phosphorylation and storage as glycogen) observed from 12 to 48 h following a single bout of exercise in humans remain unresolved. Moreover, whether these mechanisms differ with age is unclear. It is well established that a single bout of exercise increases the translocation of the glucose transporter, GLUT4, to the plasma membrane. Previous research using unilateral limb muscle contraction models in combination with hyperinsulinaemia has demonstrated that the increase in insulin sensitivity and glycogen synthesis 24 h after exercise is also associated with an increase in hexokinase II (HKII) mRNA and protein content, suggesting an increase in the capacity of the muscle to phosphorylate glucose and divert it towards glycogen synthesis...
January 12, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29322408/protocols-to-evaluate-cigarette-smoke-induced-lung-inflammation-and-pathology-in-mice
#9
Ross Vlahos, Steven Bozinovski
Cigarette smoking is a major cause of chronic obstructive pulmonary disease (COPD). Inhalation of cigarette smoke causes inflammation of the airways, airway wall remodelling, mucus hypersecretion and progressive airflow limitation. Much of the disease burden and health care utilisation in COPD is associated with the management of its comorbidities and infectious (viral and bacterial) exacerbations (AECOPD). Comorbidities, in particular skeletal muscle wasting, cardiovascular disease and lung cancer markedly impact on disease morbidity, progression and mortality...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29321394/-chrono-nutrition-and-n-3-polyunsaturated-fatty-acid
#10
Shigenobu Shibata, Akiko Furutani
Circadian clock system has been widely maintained in many spices from prokaryote to mammals. "Circadian" means "approximately day" in Latin, thus circadian rhythm means about 24 hour rhythms. The earth revolves once every 24 hours, and our circadian system has been developed for adjusting to this 24 hour cycles, to get sun light information for getting their foods or for alive in birds or mammals. We have two different circadian systems so-called main oscillator located in the suprachiasmatic nucleus (SCN) of the hypothalamus, and local oscillator located in the various peripheral organ tissues such as liver, kidney and skeletal muscle...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29317079/biotensegrity-and-myofascial-chains-a-global-approach-to-an-integrated-kinetic-chain
#11
S L Dischiavi, A A Wright, E J Hegedus, C M Bleakley
Human movement is a complex orchestration of events involving many different body systems. Understanding how these systems interact during musculoskeletal movements can directly inform a variety of research fields including: injury etiology, injury prevention and therapeutic exercise prescription. Traditionally scientists have examined human movement through a reductionist lens whereby movements are broken down and observed in isolation. The process of reductionism fails to capture the interconnected complexities and the dynamic interactions found within complex systems such as human movement...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315892/effects-of-fasted-vs-fed-state-exercise-on-performance-and-post-exercise-metabolism-a-systematic-review-meta-analysis
#12
REVIEW
Tom P Aird, Robert W Davies, Brian P Carson
The effects of nutrition on exercise metabolism and performance remains an important topic among sports scientists, clinical, and athletic populations. Recently, fasted exercise has garnered interest as a beneficial stimulus which induces superior metabolic adaptations to fed exercise in key peripheral tissues. Conversely, pre-exercise feeding augments exercise performance compared with fasting conditions. Given these seemingly divergent effects on performance and metabolism, an appraisal of the literature is warranted...
January 6, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29313601/incubation-under-fluid-dynamic-conditions-markedly-improves-the-structural-preservation-in-vitro-of-explanted-skeletal-muscles
#13
Flavia Carton, Laura Calderan, Manuela Malatesta
Explanted organs and tissues represent suitable experimental systems mimicking the functional and structural complexity of the living organism, with positive ethical and economic impact on research activities. However, their preservation in culture is generally limited, thus hindering their application as experimental models for biomedical research. In the present study, we investigated the potential of an innovative fluid dynamic culture system to improve the structural preservation in vitro of explanted mouse skeletal muscles (soleus)...
November 28, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29304996/-what-did-maxwell-s-equations-really-have-to-do-with-edison-s-invention-addressing-the-complexity-of-developing-clinical-interventions-for-skeletal-muscle-disease
#14
Jonathan Dando
To reach the healthcare market and have a medical intervention reimbursed in any format carries high risk and very low success rates. Even when all regulatory hurdles have been surpassed, there is no guarantee that the product will be purchased; a different body makes that decision using criteria typically unknown to early-stage innovators and intervention developers. In the context of skeletal muscle diseases, the field is at a crossroads; accurate diagnoses are difficult to obtain, patient management and monitoring are equally difficult, cures are evasive, and disease progression is not well enough understood in the human to identify clear targets (irrespective of whether the specific muscle disease is rare or frequent because the progression is slow and the tissue large)...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29298131/a-systematic-review-of-p53-regulation-of-oxidative-stress-in-skeletal-muscle
#15
Kaitlyn Beyfuss, David A Hood
BACKGROUND: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade of research has unravelled a dual nature in the function of p53 in mediating the oxidative stress burden. However, this is dependent on the specific properties of the applied stress and thus requires further analysis. METHODS: A systematic review was performed following an electronic search of Pubmed, Google Scholar, and ScienceDirect databases...
January 3, 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29290379/relationships-between-muscle-mass-intramuscular-adipose-and-fibrous-tissues-of-the-quadriceps-and-gait-independence-in-chronic-stroke-survivors-a-cross-sectional-study
#16
Naoki Akazawa, Kazuhiro Harada, Naomi Okawa, Kimiyuki Tamura, Atsushi Hayase, Hideki Moriyama
OBJECTIVE: To examine the relationships between muscle mass, intramuscular adipose and fibrous tissues of the quadriceps, and gait independence in chronic stroke survivors. DESIGN: Cross-sectional study. SETTING: Hospital-based research. PARTICIPANTS: Seventeen chronic stroke survivors who were unable to walk independently (non-independent walker group) and 11 chronic stroke survivors who were able to walk independently (independent walker group) participated in this study...
December 1, 2017: Physiotherapy
https://www.readbyqxmd.com/read/29288408/muscle-specific-deletion-of-prkaa1-enhances-skeletal-muscle-lipid-accumulation-in-mice-fed-a-high-fat-diet
#17
Weiche Wu, Ziye Xu, Ling Zhang, Jiaqi Liu, Jie Feng, Xinxia Wang, Tizhong Shan, Yizhen Wang
Excessive intramyocellular triacylglycerols (IMTGs, muscle lipids) are associated with the abnormal energy metabolism and insulin resistance of skeletal muscle. AMP-activated protein kinase (AMPK), a crucial cellular energy sensor, consists of α, β and γ subunits. Researchers have not clearly determined whether Prkaa1 (also known as AMPKα1) affects IMTG accumulation in skeletal muscle. Here, we show an important role of Prkaa1 in skeletal muscle lipid metabolism. Deletion of muscle Prkaa1 leads to the delayed development of skeletal muscles but does not affect glucose tolerance or insulin sensitivity in animals fed a normal diet...
December 29, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29287792/platycodon-grandiflorum-derived-saponin-attenuates-the-eccentric-exercise-induced-muscle-damage
#18
Yong-An Kim, Suck-Hoon Oh, Gi-Ho Lee, Pham Thi Hoa, Sun Woo Jin, Young Chul Chung, Young Chun Lee, Hye-Gwang Jeong
Platycodon grandiflorum contains triterpenoid saponins, such as platycodin D and platyconic acid A, and acts as a multifold nutritious compound. Our previous research demonstrated that Platycodon grandiflorum-derived saponin (PS) improves high-fat diet-induced non-alcoholic steatohepatitis and inhibits osteoclast differentiation. The pivotal effects of PS on inflammatory mechanism were suppressed NF-κB and matrix metalloproteinase (MMPs). However, the effects of PS on skeletal muscle damage remain unknown...
December 26, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29286120/influence-of-static-magnetic-fields-on-human-myoblast-mesenchymal-stem-cell-co%C3%A2-cultures
#19
Cornelia Emika Mueller, Richard Birk, Benedikt Kramer, Angela Wenzel, J Ulrich Sommer, Karl Hörmann, Jens Stern-Straeter, Christian Weilbach
The results of surgical repair of extensive muscle tissue defects are still of primary concern, leaving patients with residual cosmetic and functional impairments. Therefore, skeletal muscle tissue engineering attempts to grow functional neo‑tissue from human stem cells to promote tissue regeneration and support defect closure. Despite intensive research efforts, the goal of stable induction of myogenic differentiation in expanded human stem cells by using clinically feasible stimuli, has not yet been reached to a sufficient extent...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29283930/a-comparison-of-the-effects-of-endurance-training-on-alternate-days-and-on-consecutive-four-days-each-week-for-eight-weeks-on-the-abundance-of-pgc-1%C3%AE-camkii-nrf-1-mttfa-and-coxiv-proteins-in-rat-skeletal-muscle
#20
Jiwen Qiu, Liping Huang, Allan J Davie, Shi Zhou
The aim of this study was to compare the effects of two training protocols, training on alternate days (A) or on consecutive four days followed by three days of rest in each week (C) for eight weeks, on selected proteins involved in the biogenesis and function of mitochondria in skeletal muscle. Eighty male SD rats were randomly allocated into 10 groups (n=8 each), including Pre and Post control groups, and A or C training groups with 8, 16, 24 and 32 training sessions, respectively. The vastus lateralis and soleus muscle samples were obtained 24 hours after the last training session, or at rest for the controls...
December 27, 2017: Journal of Strength and Conditioning Research
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