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https://www.readbyqxmd.com/read/28725499/the-effect-of-metacarpophalangeal-joint-hyperextension-on-outcomes-in-the-surgical-treatment-of-carpometacarpal-joint-arthritis
#1
David M Brogan, Rose M van Hogezand, Nikola Babovic, Brian Carlsen, Sanjeev Kakar
Purpose  In the surgical treatment of thumb carpometacarpal (CMC) joint arthritis, the effect of mild preoperative metacarpophalangeal (MCP) hyperextension on postoperative functional outcomes is unknown. We sought to examine outcomes after surgical treatment of CMC arthritis in patients with and without mild preexisting MCP deformity. Methods  A retrospective review was conducted to analyze the functional outcomes of patients treated for CMC arthritis at a single institution from March 1998 to May 2009...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28718488/infectious-disease-morbidity-and-growth-among-young-hiv-exposed-uninfected-children-in-jamaica
#2
Russell B Pierre, Toni-Anne Fulford, Kaye Lewis, Paulette Palmer, Christine Walters, Celia D C Christie
Objective: There is a growing body of data that demonstrates increased infectious disease outcomes for HIV-exposed uninfected (HIV-EU) infants as compared to their HIV-unexposed (HU) counterparts. We hypothesized that these HIV-EU infants are at greater risk for infectious morbidity and mortality when compared to the general childhood population. We therefore aimed to characterize infections and growth outcomes among HIV-EU infants in Jamaica during their first two years of life. By identifying these outcomes, specific interventions could be implemented to mitigate this risk of morbidity and mortality...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28708049/identification-of-two-novel-functional-trna-derived-fragments-induced-in-response-to-respiratory-syncytial-virus-infection
#3
Jiehua Zhou, Shenxuan Liu, Yu Chen, Yu Fu, Alexander J Silver, Mark S Hill, Inhan Lee, Yong Sun Lee, Xiaoyong Bao
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in children from infancy up to early childhood. Recently, we demonstrated that RSV infection alters cellular small non-coding RNA (sncRNA) expression, most notably the tRNA-derived RNA fragments (tRFs). However, the functions of the tRFs in virus-host interaction are largely unknown. Herein, we examined the role of three RSV-induced tRFs derived from the 5-end of mature tRNAs decoding GlyCCC, LysCTT and CysGCA (named tRF5-GlyCCC, tRF5-LysCTT and tRF5-CysGCA, respectively) in controlling RSV replication...
July 15, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28695368/an-interaction-of-lps-and-rsv-infection-in-augmenting-the-ahr-and-airway-inflammation-in-mice
#4
Na Zhou, Wei Li, Luo Ren, Xiaohong Xie, Enmei Liu
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection (LRTI) in children under 5 years of age, especially infants with severe bronchiolitis. Our preliminary clinical experiments showed that bacterial colonization was commonly observed in children with virus-induced wheezing, particularly in those with recurrent wheezing, suggesting that bacterial colonization with an accompanying viral infection may contribute to disease severity. In most cases, RSV-infected infants were colonized with pathogenic bacteria (mainly Gram-negative bacteria)...
July 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28685589/surgeon-preference-influence-and-treatment-of-thumb-carpometacarpal-arthritis
#5
Zachary Deutch, Steven R Niedermeier, Hisham M Awan
BACKGROUND: The purpose of this study was to evaluate current surgical practice patterns, the factors that influence these patterns, and overall trends in the treatment of thumb carpometacarpal osteoarthritis. METHODS: An online survey containing 14 questions was sent to all active members of the American Society for Surgery of the Hand. Information on demographics and treatments was collected. Results were anonymously uploaded to an online spreadsheet. RESULTS: A total of 823 responses were recorded...
July 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28667205/prospective-observational-study-in-two-dutch-hospitals-to-assess-the-performance-of-inflammatory-plasma-markers-to-determine-disease-severity-of-viral-respiratory-tract-infections-in-children
#6
Inge M L Ahout, Kim H Brand, Aldert Zomer, Wilhelma H van den Hurk, Geurt Schilders, Marianne L Brouwer, Chris Neeleman, Ronald de Groot, Gerben Ferwerda
INTRODUCTION: Respiratory viruses causing lower respiratory tract infections (LRTIs) are a major cause of hospital admissions in children. Since the course of these infections is unpredictable with potential fast deterioration into respiratory failure, infants are easily admitted to the hospital for observation. The aim of this study was to examine whether systemic inflammatory markers can be used to predict severity of disease in children with respiratory viral infections. METHODS: Blood and nasopharyngeal washings from children <3 years of age with viral LRTI attending a hospital were collected within 24 hours (acute) and after 4-6 weeks (recovery)...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28660356/community-acquired-lower-respiratory-tract-infections-in-hiv-infected-patients-on-antiretroviral-therapy-predictors-in-a-contemporary-cohort-study
#7
Cristiane C Lamas, Lara E Coelho, Beatriz J Grinsztejn, Valdilea G Veloso
Community-acquired pneumonia represents the most frequent bacterial infection in patients with HIV/AIDS. PURPOSE: We aimed to assess variables associated with lower respiratory tract infection (LRTI) among HIV-infected adults using ART. METHODS: A cohort study of HIV-infected patients aged ≥18 years, enrolled from 2000 to 2015, on ART for at least 60 days, with primary outcome as the 1st episode of LRTI during follow-up. The independent variables included were sex at birth, age, race/skin color, educational level, tobacco smoking, alcohol use, cocaine use, diabetes mellitus, CD4 count, HIV viral load, influenza and pneumococcal vaccination...
June 28, 2017: Infection
https://www.readbyqxmd.com/read/28657793/pulmonary-infections-in-the-elderly-lead-to-impaired-neutrophil-targeting-improved-by-simvastatin
#8
Elizabeth Sapey, Jaimin M Patel, Hannah L Greenwood, Georgia M Walton, Jon Hazeldine, Charendeep Sadhra, Dhruv Parekh, Rachel Ca Dancer, Peter Nightingale, Janet M Lord, David R Thickett
RATIONALE: Dysregulated neutrophil functions are described with age and sepsis. Statins are associated with improved infection survival in some observational studies but trials in critically ill patients have not shown benefit. Statins also alter neutrophil responses in vitro. OBJECTIVE: To assess neutrophil migratory accuracy with age during respiratory infections and determine if and how a statin intervention could alter these blunted responses. METHODS: Migratory accuracy of blood neutrophils from young (aged<35) and old (aged>60) patients in health, during a lower respiratory tract infection (LRTI), pneumonia (CAP) and pneumonia associated sepsis (S-CAP) was assessed with and without simvastatin...
June 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28648328/functional-outcomes-of-thumb-trapeziometacarpal-arthrodesis-with-a-locked-plate-versus-ligament-reconstruction-and-tendon-interposition
#9
K J Hippensteel, Ryan Calfee, Agnes Z Dardas, Richard Gelberman, Daniel Osei, Lindley Wall
PURPOSE: To compare standardized functional and patient-reported early outcomes following trapeziometacarpal arthrodesis (TMA) using a locking cage plate construct with trapezial excision, ligament reconstruction, and tendon interposition (LRTI). METHODS: This prospective cohort enrolled 50 consecutive patients with trapeziometacarpal osteoarthritis undergoing TMA or LRTI. Demographic data, objective measurements, Sollerman function testing, and patient-reported outcomes were collected before surgery and at various time intervals up to 12 months after surgery...
June 22, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28628889/the-innate-immune-response-to-lower-respiratory-tract-e-coli-infection-and-the-role-of-the-ccl2-ccr2-axis-in-neonatal-mice
#10
Sharon A McGrath-Morrow, Roland Ndeh, Joseph M Collaco, Amy K Poupore, Dustin Dikeman, Qiong Zhong, Benjamin D Singer, Franco D'Alessio, Alan Scott
Neonates have greater morbidity/mortality from lower respiratory tract infections (LRTI) compared to older children. Lack of conditioning of the pulmonary immune system due to limited environmental exposures and/or infectious challenges likely contributes to the increase susceptibility in the neonate. In this study, we sought to gain insights into the nature and dynamics of the neonatal pulmonary immune response to LRTI using a murine model. METHODS: Wildtype (WT) and Ccr2(-/-) C57BL/6 neonatal and juvenile mice received E...
September 2017: Cytokine
https://www.readbyqxmd.com/read/28578344/the-comparison-of-procalcitonin-guidance-administer-antibiotics-with-standard-guidelines-on-antibiotic-therapy-in-children-with-lower-respiratory-tract-infections-a-retrospective-study-in-china
#11
Guo Wu, Gao Wu, Shuxie Wu, Hanbin Wu
OBJECTIVE: To establish the efficacy of an algorithm based on the biomarker procalcitonin (PCT) to reduce antibiotic exposure in pediatric patients with lower respiratory tract infection (LRTI). MATERIALS AND METHODS: The clinical data of 357 patients (age of <14 years) who were discharged home with lower respiratory tract infections(LRTI) from Jan 1, 2010 to Jul 31, 2016, were analyzed. The antibiotic exposure, antibiotic prescription rate, length of hospital stay and antibiotic-associated adverse effects were compared between PCT group (n=183) and standard group (n=174) using SAS 9...
June 1, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28574729/respiratory-syncytial-virus-prospects-for-new-and-emerging-therapeutics
#12
Patricia A Jorquera, Ralph A Tripp
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infections (LRTI) in infants, the elderly, and the immunocompromised. Although the development of a RSV vaccine has been a priority for >50 years, there is still no vaccine available. Treatment of RSV LRTI has remained mostly supportive, i.e. hydration and oxygenation. Palivizumab and ribavirin are the only options currently available for prevention and treatment of RSV infection, but evidence suggests that they are not fully effective...
August 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28571896/-short-term-relevance-of-lower-respiratory-viral-coinfection-in-inpatients-under-2-years-of-age
#13
Joana Gil, Sofia Almeida, Carolina Constant, Sara Pinto, Rosário Barreto, José Melo Cristino, Maria do Céu Machado, Teresa Bandeira
INTRODUCTION: Advances in molecular diagnosis have made it possible to detect previously unknown viral agents as causative agents of lower respiratory tract infections (LRTI). The frequency and relevance of viral coinfections is still debatable. OBJECTIVE: compare clinical presentation and severity between single virus infection and viral coinfection in children admitted for LRTI. METHODS: A 3-year period observational study (2012-2015) included children younger than two years admitted for LRTI...
May 29, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28531552/the-role-of-next-generation-sequencing-in-infection-prevention-in-human-parainfluenza-virus-3-infections-in-immunocompromised-patients
#14
Atul Kothari, Mary J Burgess, Juan Carlos Rico Crescencio, Joshua L Kennedy, Jesse L Denson, Kurt C Schwalm, Ashley N Stoner, John C Kincaid, Faith E Davies, Darrell L Dinwiddie
BACKGROUND: Respiratory viral infections are a significant problem in patients with hematologic malignancies. We report a cluster of HPIV 3 infections in our myeloma patients, and describe the utility of next generation sequencing (NGS) to identify transmission linkages which can assist in infection prevention. OBJECTIVES: To evaluate the utility of NGS to track respiratory viral infection outbreaks and delineate between community acquired and nosocomial infections in our cancer units...
July 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28529684/c-reactive-protein-and-radiographic-findings-of-lower-respiratory-tract-infection-in-infants
#15
Maria Twomey, Hannah Fleming, Fiachra Moloney, Kevin P Murphy, Lee Crush, Siobhan B O'Neill, Oisin Flanagan, Karl James, Conor Bogue, Owen J O'Connor, Michael M Maher
AIM: To evaluate the association between C-reactive protein (CRP) and radiological evidence of lower respiratory tract infection (LRTI) in infants. METHODS: All patients aged less than 4 years who presented with suspected lower respiratory tract infection, who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study. Age, gender, source of referral, CRP, white cell count, neutrophil count along with the patients' symptoms and radiologist's report were recorded...
April 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28481387/trapeziectomy-with-ligament-reconstruction-and-tendon-interposition-versus-a-trapeziometacarpal-prosthesis-for-the-treatment-of-thumb-basal-joint-osteoarthritis
#16
María José Robles-Molina, Francisco López-Caba, Rafael C Gómez-Sánchez, Encarnación Cárdenas-Grande, Miguel Pajares-López, Pedro Hernández-Cortés
Numerous surgical procedures have been described to treat trapeziometacarpal osteoarthritis, but no approach is currently considered superior. Good long-term outcomes have been reported with multiple procedures. No studies have been published comparing outcomes of the Arpe joint replacement (Biomet, Valence, France) with those of ligament reconstruction and tendon interposition (LRTI) using the Burton-Pellegrini technique. The study objective was to compare clinical outcomes between these techniques. Sixty-five patients with Eaton stage III osteoarthritis of the thumb were included in this retrospective follow-up study...
July 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/28461899/do-influenza-and-pneumococcal-vaccines-prevent-community-acquired-respiratory-infections-among-older-people-with-diabetes-and-does-this-vary-by-chronic-kidney-disease-a-cohort-study-using-electronic-health-records
#17
Helen I McDonald, Sara L Thomas, Elizabeth R C Millett, Jennifer Quint, Dorothea Nitsch
OBJECTIVE: We aimed to estimate the effectiveness of influenza and 23-valent pneumococcal polysaccharide vaccination on reducing the burden of community-acquired lower respiratory tract infection (LRTI) among older people with diabetes, and whether this varied by chronic kidney disease (CKD) status. RESEARCH DESIGN AND METHODS: We used linked UK electronic health records for a retrospective cohort study of 190 492 patients ≥65 years with diabetes mellitus and no history of renal replacement therapy, 1997-2011...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28376442/prevalence-of-atypical-pathogens-in-patients-with-cough-and-community-acquired-pneumonia-a-meta-analysis
#18
REVIEW
Christian Marchello, Ariella Perry Dale, Thuy Nhu Thai, Duk Soo Han, Mark H Ebell
PURPOSE: Community-acquired pneumonia (CAP), acute cough, bronchitis, and lower respiratory tract infections (LRTI) are often caused by infections with viruses or Streptococcus pneumoniae. The prevalence of atypical pathogens Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis among patients with these illnesses in the ambulatory setting has not been previously summarized. We set out to derive prevalence information from the existing literature...
November 2016: Annals of Family Medicine
https://www.readbyqxmd.com/read/28376440/disease-course-of-lower-respiratory-tract-infection-with-a-bacterial-cause
#19
Jolien Teepe, Berna D L Broekhuizen, Katherine Loens, Christine Lammens, Margareta Ieven, Herman Goossens, Paul Little, Christopher C Butler, Samuel Coenen, Maciek Godycki-Cwirko, Theo Verheij
PURPOSE: Bacterial pathogens are assumed to cause an illness course different from that of nonbacterial causes of acute cough, but evidence is lacking. We evaluated the disease course of lower respiratory tract infection (LRTI) with a bacterial cause in adults with acute cough. METHODS: We conducted a secondary analysis of a multicenter European trial in which 2,061 adults with acute cough (28 days' duration or less) were recruited from primary care and randomized to amoxicillin or placebo...
November 2016: Annals of Family Medicine
https://www.readbyqxmd.com/read/28368089/withdrawn-surgery-for-thumb-trapeziometacarpal-joint-osteoarthritis
#20
REVIEW
Anne Wajon, Toby Vinycomb, Emma Carr, Ian Edmunds, Louise Ada
BACKGROUND: Surgery is used to treat persistent pain and dysfunction at the base of the thumb when conservative management, such as splinting, or medical management, such as oral analgesics, is no longer adequate in reducing disability and pain. This is an update of a Cochrane Review first published in 2005. OBJECTIVES: To assess the effects of different surgical techniques for trapeziometacarpal (thumb) osteoarthritis. SEARCH METHODS: We searched the following sources up to 08 August 2013: CENTRAL (The Cochrane Library 2013, Issue 8), MEDLINE (1950 to August 2013), EMBASE (1974 to August 2013), CINAHL (1982 to August 2013), Clinicaltrials...
April 3, 2017: Cochrane Database of Systematic Reviews
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