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https://www.readbyqxmd.com/read/29790677/predicting-healthcare-outcomes-in-prematurely-born-infants-using-cluster-analysis
#1
Victoria MacBean, Alan Lunt, Simon B Drysdale, Muska N Yarzi, Gerrard F Rafferty, Anne Greenough
AIMS: Prematurely born infants are at high risk of respiratory morbidity following neonatal unit discharge, though prediction of outcomes is challenging. We have tested the hypothesis that cluster analysis would identify discrete groups of prematurely born infants with differing respiratory outcomes during infancy. METHODS: A total of 168 infants (median (IQR) gestational age 33 (31-34) weeks) were recruited in the neonatal period from consecutive births in a tertiary neonatal unit...
May 23, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29750895/predictors-and-incidence-of-hospitalization-due-to-respiratory-syncytial-virus-rsv-associated-lower-respiratory-tract-infection-lrti-in-non-prophylaxed-moderate-to-late-preterm-infants-in-bosnia-and-herzegovina
#2
Hajrija Maksić, Suada Heljić, Fahrija Skokić, Darinka Šumanović-Glamuzina, Veroslava Milošević, Almir Zlatanović, Notario Gerard
Prematurity is a risk factor for respiratory syncytial virus (RSV)-associated lower respiratory tract infections (LRTIs), due to immature humoral and cell-mediated immune system in preterm newborns, as well as their incomplete lung development. Palivizumab, a humanized monoclonal antibody against the F glycoprotein of RSV, is licensed for the prevention of severe RSV LRTI in children at high risk for the disease. This study is a part of a larger observational, retrospective-prospective epidemiological study (PONI) conducted at 72 sites across 23 countries in the northern temperate zone...
April 27, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29715176/procalcitonin-guidance-in-patients-with-lower-respiratory-tract-infections-a-systematic-review-and-meta-analysis
#3
REVIEW
Juliane Hey, Philippe Thompson-Leduc, Noam Y Kirson, Louise Zimmer, Dana Wilkins, Bernie Rice, Irena Iankova, Alexander Krause, Sophie A Schonfeld, Christopher R DeBrase, Samuel Bozzette, Philipp Schuetz
Although effective for bacterial lower respiratory tract infections (LRTIs), antibiotic treatment is often incorrectly prescribed for non-bacterial LRTIs. Procalcitonin has emerged as a promising biomarker to diagnose bacterial infections and guide antibiotic treatment decisions. As part of a regulatory submission to the U.S. Food and Drug Administration, this systematic review and meta-analysis summarizes the effects of procalcitonin-guided antibiotic stewardship on antibiotic use and clinical outcomes in adult LRTI patients...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29712621/incidence-of-lower-respiratory-tract-infections-and-atopic-conditions-in-boys-and-young-male-adults-royal-college-of-general-practitioners-research-and-surveillance-centre-annual-report-2015-2016
#4
Simon de Lusignan, Ana Correa, Richard Pebody, Ivelina Yonova, Gillian Smith, Rachel Byford, Sameera Rankiri Pathirannehelage, Christopher McGee, Alex J Elliot, Mariya Hriskova, Filipa Im Ferreira, Imran Rafi, Simon Jones
BACKGROUND: The Royal College of General Practitioners Research and Surveillance Centre comprises more than 150 general practices, with a combined population of more than 1.5 million, contributing to UK and European public health surveillance and research. OBJECTIVE: The aim of this paper was to report gender differences in the presentation of infectious and respiratory conditions in children and young adults. METHODS: Disease incidence data were used to test the hypothesis that boys up to puberty present more with lower respiratory tract infection (LRTI) and asthma...
April 30, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29707461/partial-versus-total-trapeziectomy-thumb-arthroplasty-an-expertise-based-feasibility-study
#5
Achilleas Thoma, Carolyn Levis, Pinkal Patel, Jessica Murphy, Eric Duku
Background: There are numerous surgical techniques for the treatment of first carpometacarpal joint osteoarthritis, however, controversy exists as to whether outcomes differ between techniques. This feasibility study aimed to determine if a large-scale, health-related quality of life and functional outcomes study comparing 2 surgical techniques, complete trapeziectomy with ligament reconstruction and tendon interposition (T + LRTI) versus partial trapeziectomy and tendon interposition (PT + TI) arthroplasty, is possible...
March 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29699468/lower-respiratory-tract-infection-and-short-term-outcome-in-patients-with-acute-respiratory-distress-syndrome
#6
Fernando G Zampieri, Pedro Póvoa, Jorge I Salluh, Alejandro Rodriguez, Sandrine Valade, José Andrade Gomes, Jean Reignier, Elena Molinos, Jordi Almirall, Nicolas Boussekey, Lorenzo Socias, Paula Ramirez, William N Viana, Anahita Rouzé, Saad Nseir, Ignacio Martin-Loeches
OBJECTIVE: To assess whether ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with mortality in critically ill patients with acute respiratory distress syndrome (ARDS). MATERIALS AND METHODS: Post hoc analysis of prospective cohort study including mechanically ventilated patients from a multicenter prospective observational study (TAVeM study); VA-LRTI was defined as either ventilator-associated tracheobronchitis (VAT) or ventilator-associated pneumonia (VAP) based on clinical criteria and microbiological confirmation...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29698412/clinical-manifestations-in-infants-and-children-with-mycoplasma-pneumoniae-infection
#7
Mia Johanna Søndergaard, Martin Barfred Friis, Dennis Schrøder Hansen, Inger Merete Jørgensen
BACKGROUND: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in older children. Pulmonary and extra-pulmonary symptoms associated with M. pneumoniae infection are reported. M. pneumoniae is mainly epidemic in Denmark with the recurrence every 4-7th year. AIMS: Retrospectively, to describe the epidemiology and clinical features, in infants and children, during the M. pneumoniae epidemic in 2010 and 2011. METHODS: All children under the age of 16 that were tested for M...
2018: PloS One
https://www.readbyqxmd.com/read/29681706/esophageal-lung-clinical-images
#8
Vivek Kumar Singh, Anjan Kumar Dhua, Manisha Jana, Veereshwar Bhatnagar
Esophageal lung (EL) is a highly rare anomaly, wherein the bronchus of a lung connects directly with the esophagus. Repeated lower respiratory tract infection (LRTI) is the hallmark of this condition. We present the clinical images of a 5-month-old boy who presented with repeated LRTI since birth. On evaluation, EL was diagnosed. Excision of the lung with abnormally communicating bronchus and primary repair of the esophagus was curative.
April 2018: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/29674425/impact-of-gut-colonization-with-butyrate-producing-microbiota-on-respiratory-viral-infection-following-allo-hct
#9
Bastiaan W Haak, Eric R Littmann, Jean-Luc Chaubard, Amanda J Pickard, Emily Fontana, Fatima Adhi, Yangtsho Gyaltshen, Lilan Ling, Sejal M Morjaria, Jonathan U Peled, Marcel R van den Brink, Alexander I Geyer, Justin R Cross, Eric G Pamer, Ying Taur
Respiratory viral infections are frequent in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT), and can potentially progress to lower respiratory tract infection (LRTI). The intestinal microbiota contributes to resistance against viral and bacterial pathogens in the lung. However, whether intestinal microbiota composition and associated changes in microbe-derived metabolites contribute to the risk of LRTI following upper respiratory tract viral infection remains unexplored in the setting of allo-HCT...
April 19, 2018: Blood
https://www.readbyqxmd.com/read/29659754/a-randomized-study-evaluating-the-effectiveness-of-oseltamivir-initiated-at-the-time-of-hospital-admission-in-adults-hospitalized-with-influenza-associated-lower-respiratory-tract-infections
#10
Julio Ramirez, Paula Peyrani, Timothy Wiemken, Sandra S Chaves, Alicia M Fry
Background: Influenza-associated hospitalizations result in high morbidity and mortality. We sought to determine if early empiric anti-influenza therapy improves outcomes of hospitalized patients with influenza-associated lower respiratory tract infections (I-LRTIs). Methods: This was a randomized, unblinded, trial of adult patients hospitalized with I-LRTIs in Kentucky during 2009-2012. Patients were randomized to group A (standard of care) or group B (standard of care plus oseltamivir as early as possible but within 24 hours of enrollment)...
April 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29625943/drug-utilization-and-prescribing-pattern-of-antibiotics-in-a-tertiary-care-setups-trends-and-practices
#11
Huma Ali, Farya Zafar, Shazia Alam, Anwar Ejaz Beg, Rabia Bushra, Ammara Manzoor, Ghazala R Naqvi, Riffat Yasmeen, Yousra Shafiq, Anum Tariq, Saba Zubair, Saima Saleem
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29620934/factors-associated-with-lower-respiratory-tract-infections-in-hiv-exposed-uninfected-infants
#12
Adriana Weinberg, Marisa Mussi-Pinhata, Qilu Yu, Rachel A Cohen, Volia C Almeida, Fabiana R Amaral, Laura Freimanis, D Robert Harris, Christiana Smith, George Siberry
OBJECTIVES: To identify factors that predispose HIV-exposed uninfected infants (HEUs) to higher incidence of severe infections, hospitalization and death in the first 6 to 24 months of life compared with HEUs with and without lower respiratory tract infection (LRTI) in the first 6 months of life. DESIGN: Nested case-control study of 107 LRTI+ infants enrolled in the NISDI Perinatal and LILAC studies with and 140 LRTI- in the first 6 months of, matched by date and place of birth...
March 18, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29619885/outcomes-of-surgical-management-for-thumb-basilar-arthritis-in-patients-55-years-of-age-and-younger
#13
Peter C Rhee, Aaron Paul, Brian Carlsen, Alexander Y Shin
BACKGROUND: Trapeziectomy with ligament reconstruction tendon interposition (LRTI) or suspensionplasty is an effective treatment in older patients with end-stage thumb basilar arthritis. However, the survivability of this procedure is unknown in younger patients who may impart more stress on their thumbs. METHODS: A retrospective review was performed on all patients who underwent trapeziectomy and LRTI or suspensionplasty at 55 years of age or younger from 1992 to 2008...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29601448/antibiotic-overuse-in-children-with-respiratory-syncytial-virus-lower-respiratory-tract-infection
#14
Chantal B van Houten, Christiana Naaktgeboren, Brigitte J M Buiteman, Maaike van der Lee, Adi Klein, Isaac Srugo, Irina Chistyakov, Wouter de Waal, Clemens B Meijssen, Pieter W Meijers, Karin M de Winter-de Groot, Tom F W Wolfs, Yael Shachor-Meyouhas, Michal Stein, Elisabeth A M Sanders, Louis J Bont
BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections (LRTI) during the first year of life. Antibiotic treatment is recommended in cases suspected of bacterial co-infection. The aim of this prospective study is to estimate the incidence of bacterial co-infections, and the amount of antibiotic overuse in children infected with RSV using expert panel diagnosis. METHODS: Children one month of age and over with LRTI or fever without source were prospectively recruited in hospitals in the Netherlands and Israel...
March 29, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29601438/proton-pump-inhibitors-and-infant-pneumonia-other-lower-respiratory-tract-infections-national-nested-case-control-study
#15
Mei-Ling Blank, Lianne Parkin, Jiaxu Zeng, David Barson
OBJECTIVE: The possible association between the use of proton pump inhibitors (PPIs) and community-acquired pneumonia (CAP) or any lower respiratory tract infection (LRTI) remains uncertain. We conducted a nested case-control study using routinely collected national health and drug dispensing data in New Zealand to examine the risk of CAP or any LRTI resulting in hospitalization or death in infants dispensed a PPI. STUDY DESIGN: The cohort included 21,991 patients without a history of CAP or any LRTI who were born between 1 January 2005 and 31 December 2012 and were dispensed omeprazole, lansoprazole, or pantoprazole (the PPIs available in New Zealand during the study period) on at least one occasion during the first year of life...
March 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29595674/outcomes-of-modified-trapeziectomy-with-ligament-reconstruction-tendon-interposition-for-the-treatment-of-advanced-thumb-carpometacarpal-arthritis-two-year-follow-up
#16
Tao Wang, Gang Zhao, Yong-Jun Rui, Jing-Yi Mi
Numerous arthroplasty techniques had been reported for the treatment of thumb carpometacarpal (CMC) joint osteoarthritis. The purpose of our study is to evaluate long-term clinical and radiographic outcomes of patients who underwent modified trapeziectomy with ligament reconstruction tendon interposition (LRTI).Our retrospective study included 20 consecutive patients with advanced thumb CMC arthritis receiving modified trapeziectomy with LRTI (20 thumbs). For clinical evaluation, we assessed visual analogue scale (VAS), Disabilities of the Arm, Shoulder and Hand (DASH) scores and Kapandji index...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29555393/cytokine-kinetic-profiles-in-children-with-acute-lower-respiratory-tract-infection-a-post-hoc-descriptive-analysis-from-a-randomized-control-trial
#17
Aline Fuchs, Verena Gotta, Marie-Luise, Gabor Szinnai, Philipp Baumann, Jan Bonhoeffer, Nicole Ritz
OBJECTIVE: Standard inflammatory markers and chest radiography lack the ability to discriminate bacterial from non-bacterial lower respiratory tract infection (LRTI). Cytokine profiles may serve as biomarkers for LRTI, but their applicability to identify aetiology, severity of disease and need for antibiotic prescription in children remains poorly defined. Objectives were to determine the cytokine kinetic profiles over five days in paediatric patients with LRTI, to investigate the relationship between cytokine patterns, and clinical and laboratory variables...
March 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29542189/risks-for-upper-respiratory-infections-in-infants-during-their-first-months-in-day-care-included-environmental-and-child-related-factors
#18
Rikke Pilmann Laursen, Anni Larnkjaer, Christian Ritz, Iva Hojsak, Kim Michaelsen, Christian Mølgaard
AIM: We examined the frequency and potential risk factors for respiratory infections, diarrhoea and absences in infants during their first months in day care. METHODS: This prospective cohort study comprised 269 Danish infants aged eight months to 14 months and was part of a study that examined how probiotics affected absences from day care due to respiratory and gastrointestinal infections. The risk factors examined were the household, child characteristics and type of day care facility...
March 14, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29536504/respiratory-morbidity-in-rett-syndrome-an-observational-study
#19
Jessica MacKay, Helen Leonard, Kingsley Wong, Andrew Wilson, Jenny Downs
AIM: Respiratory illness is a major cause of morbidity and mortality in Rett syndrome. This study investigated respiratory morbidity and relationships with age, mutation type, feeding, and walking status. METHOD: Families registered with the InterRett database (n=399) provided data on the health of their child with Rett syndrome (age 2-57y). Hospital admissions because of lower respiratory tract infection (LRTI) over a 5-year exposure period were investigated by age, mutation type, enteral feeding, and walking status...
March 14, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29533129/safety-study-of-live-oral-human-rotavirus-vaccine-a-cohort-study-in-united-states-health-insurance-plans
#20
Veena Hoffman, Remon Abu-Elyazeed, Cheryl Enger, Daina B Esposito, Michael C Doherty, Scott C Quinlan, Kathleen Skerry, Crystal N Holick, Peter Basile, Leonard R Friedland, Nicolas Praet, Stéphanie Wéry, Corinne Willame, David D Dore, Dominique Rosillon
As part of a regulatory commitment for post-licensure safety monitoring of live, oral human rotavirus vaccine (RV1), this study compared the incidence rates (IR) of intussusception, acute lower respiratory tract infection (LRTI) hospitalization, Kawasaki disease, convulsion, and mortality in RV1 recipients versus inactivated poliovirus vaccine (IPV) recipients in concurrent (cIPV) and recent historical (hIPV) comparison cohorts. Vaccine recipients were identified in 2 claims databases from August 2008 - June 2013 (RV1 and cIPV) and January 2004 - July 2008 (hIPV)...
March 13, 2018: Human Vaccines & Immunotherapeutics
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