keyword
MENU ▼
Read by QxMD icon Read
search

Lrti

keyword
https://www.readbyqxmd.com/read/28097633/meropenem-dosing-based-on-a-population-pharmacokinetic-pharmacodynamic-model-in-elderly-patients-with-infection-of-the-lower-respiratory-tract
#1
Qing-Tao Zhou, Bei He, Ning Shen, Ying Liang, Li-Na Sun
BACKGROUND: Meropenem is used for the treatment of severe lower respiratory tract infections (LRTIs) caused by multidrug-resistant Gram-negative bacilli. OBJECTIVE: We evaluated the clinical benefits of a strategy of meropenem dosing based on a population pharmacokinetics/pharmacodynamics (PK/PD) model in elderly patients with an LRTI. METHODS: In this prospective single-center open-label randomized controlled trial, 79 elderly patients with an LRTI caused by Gram-negative bacilli were randomized to a study group (SG) or a control group (CG)...
January 17, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28095451/comparing-human-metapneumovirus-and-respiratory-syncytial-virus-viral-co-detections-genotypes-and-risk-factors-for-severe-disease
#2
Nina Moe, Sidsel Krokstad, Inger Heimdal Stenseng, Andreas Christensen, Lars Høsøien Skanke, Kari Ravndal Risnes, Svein Arne Nordbø, Henrik Døllner
BACKGROUND: It is unclarified as to whether viral co-detection and human metapneumovirus (HMPV) genotypes relate to clinical manifestations in children with HMPV and lower respiratory tract infection (LRTI), and if the clinical course and risk factors for severe LRTI differ between HMPV and respiratory syncytial virus (RSV). METHODS: We prospectively enrolled hospitalized children aged <16 years with LRTI from 2006 to 2015. Children were clinically examined, and nasopharyngeal aspirates were analyzed using semi-quantitative, real-time polymerase chain reaction tests for HMPV, RSV and 17 other pathogens...
2017: PloS One
https://www.readbyqxmd.com/read/28086957/regulatory-t-cells-and-il10-suppress-pulmonary-host-defense-during-early-life-exposure-to-radical-containing-combustion-derived-ultrafine-particulate-matter
#3
Sridhar Jaligama, Jordy Saravia, Dahui You, Nikki Yadav, Greg I Lee, Bishwas Shrestha, Stephania A Cormier
BACKGROUND: Exposure to elevated levels of particulate matter (PM) is associated with increased risk of morbidity and mortality due to respiratory tract viral infections in infants. Recent identification of environmentally persistent free radicals (EPFRs) in the PM from a variety of combustion sources suggests its role in the enhancement of disease severity of lower respiratory tract infections (LRTI). Our previous studies demonstrated that acute exposure to EPFRs induces pulmonary immunosuppression allowing for enhanced influenza disease severity...
January 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28058797/estimating-the-burden-of-respiratory-syncytial-virus-rsv-on-respiratory-hospital-admissions-in-children-less-than-five-years-of-age-in-england-2007-2012
#4
R M Reeves, P Hardelid, R Gilbert, F Warburton, J Ellis, R G Pebody
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of hospital admission in young children. With several RSV vaccines candidates undergoing clinical trials, recent estimates of RSV burden are required to provide a baseline for vaccine impact studies. OBJECTIVES: To estimate the number of RSV-associated hospital admissions in children <5 years old in England over a 5-year period from 2007 using ecological time series modelling of national hospital administrative data...
January 6, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28054734/compassionate-use-experience-with-high-titer-respiratory-syncytical-virus-rsv-immunoglobulin-in-rsv-infected-immunocompromised-persons
#5
Ann R Falsey, Christine Koval, John P DeVincenzo, Edward E Walsh
BACKGROUND: Respiratory syncytial virus (RSV) may cause fatal lower respiratory tract infection (LRTI) in immunocompromised patients. Ribavirin with or without standard intravenous immunoglobulin (IVIG) is frequently given although efficacy is debated. Infusion of IVIG with high levels of neutralizing antibody against RSV may offer benefit in these patients. METHODS: RI-001 contains standardized levels of high-titer anti-RSV neutralizing antibody and was provided for compassionate use to 15 patients with RSV LRTI who either failed conventional therapy or had significant risk of progression...
January 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28005485/infectious-disease-hospitalizations-among-american-indian-alaska-native-and-non-american-indian-alaska-native-persons-in-alaska-2010-2011
#6
Prabhu P Gounder, Robert C Holman, Sara M Seeman, Alice J Rarig, Mary McEwen, Claudia A Steiner, Michael L Bartholomew, Thomas W Hennessy
OBJECTIVE: Reports about infectious disease (ID) hospitalization rates among American Indian/Alaska Native (AI/AN) persons have been constrained by data limited to the tribal health care system and by comparisons with the general US population. We used a merged state database to determine ID hospitalization rates in Alaska. METHODS: We combined 2010 and 2011 hospital discharge data from the Indian Health Service and the Alaska State Inpatient Database. We used the merged data set to calculate average annual age-adjusted and age-specific ID hospitalization rates for AI/AN and non-AI/AN persons in Alaska...
January 2017: Public Health Reports
https://www.readbyqxmd.com/read/27927871/severity-of-respiratory-syncytial-virus-lower-respiratory-tract-infection-with-viral-coinfection-in-hiv-uninfected-children
#7
Natalie I Mazur, Louis Bont, Adam L Cohen, Cheryl Cohen, Anne von Gottberg, Michelle J Groome, Orienka Hellferscee, Kerstin Klipstein-Grobusch, Omphile Tschegofatso Mekgoe, Fathima Naby, Jocelyn Moyes, Stefano Tempia, Florette K Treurnicht, Marietje Venter, Sibongile Walaza, Nicole Wolter, Shabir A Madhi
BACKGROUND: Molecular diagnostics enable sensitive detection of respiratory viruses but their clinical significance remains unclear in pediatric lower respiratory tract infections (LRTI). We aimed to determine whether viral coinfections increased life-threatening disease in a large cohort. METHODS: Molecular testing was performed for respiratory viruses in nasopharyngeal aspirates collected from children aged <5 years within 24 hours of hospital admission during sentinel surveillance for Severe Acute Respiratory Illness (SARI) hospitalisation conducted in South Africa during February 2009-December 2013...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27915460/zinc-supplementation-for-the-prevention-of-pneumonia-in-children-aged-2-months-to-59-months
#8
REVIEW
Zohra S Lassi, Anoosh Moin, Zulfiqar A Bhutta
BACKGROUND: Pneumonia is a leading cause of morbidity and mortality in children younger than five years of age. Most deaths occur during infancy and in low-income countries. Daily zinc supplements have been reported to prevent acute lower respiratory tract infection (LRTI) and reduce child mortality. This is an update of a review first published in 2010. OBJECTIVES: To evaluate the effectiveness of zinc supplementation in the prevention of pneumonia in children aged two to 59 months...
4, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27884552/estimated-saving-of-antibiotics-in-pharyngitis-and-lower-respiratory-tract-infections-if-general-practitioners-used-rapid-tests-and-followed-guidelines
#9
Carles Llor, Ana Moragas, Josep M Cots, Beatriz González López-Valcárcel
INTRODUCTION: General practitioners (GP) in Spain do not have access to rapid tests and adherence to guidelines is usually suboptimal. The aim of the study is to evaluate the estimated number of antibiotics that could have been saved if GPs had appropriately used these tests and had followed the guidelines. DESIGN: Observational study. SETTING: Primary care centres from eight Autonomous Communities in Spain. PARTICIPANTS: GPs who had not participated in previous studies on rational use of antibiotics...
November 21, 2016: Atencion Primaria
https://www.readbyqxmd.com/read/27882804/a-comparison-of-high-frequency-chest-wall-oscillation-and-intrapulmonary-percussive-ventilation-for-airway-clearance-in-pediatric-patients-with-tracheostomy
#10
Aneela Bidiwala, Linda Volpe, Claudia Halaby, Melissa Fazzari, Christina Valsamis, Melodi Pirzada
OBJECTIVES: The aim of this study was to compare two modes of airway clearance, the intrapulmonary percussive ventilation system (IPV) to high frequency chest wall oscillation system (HFCWO) in medically complex pediatric patients with tracheostomy requiring long term care. METHODS: This was a single center, retrospective study comparing the number of respiratory illnesses, lower respiratory tract infections (LRTI), utilization of bronchodilator and systemic steroids, and respiratory illnesses requiring acute care hospitalizations...
December 11, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27873511/human-coronavirus-in-the-2014-winter-season-as-a-cause-of-lower-respiratory-tract-infection
#11
Kyu Yeun Kim, Song Yi Han, Ho Seong Kim, Hyang Min Cheong, Sung Soon Kim, Dong Soo Kim
PURPOSE: During the late autumn to winter season (October to December) in the Republic of Korea, respiratory syncytial virus (RSV) is the most common pathogen causing lower respiratory tract infections (LRTIs). Interestingly, in 2014, human coronavirus (HCoV) caused not only upper respiratory infections but also LRTIs more commonly than in other years. Therefore, we sought to determine the epidemiology, clinical characteristics, outcomes, and severity of illnesses associated with HCoV infections at a single center in Korea...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27859623/plasma-cytokines-eotaxin-mip-1%C3%AE-mcp-4-and-vascular-endothelial-growth-factor-in-acute-lower-respiratory-tract-infection
#12
Mette Marie Relster, Anette Holm, Court Pedersen
Major overlaps of clinical characteristics and the limitations of conventional diagnostic tests render the initial diagnosis and clinical management of pulmonary disorders difficult. In this pilot study, we analyzed the predictive value of eotaxin, macrophage inflammatory protein 1 alpha (MIP-1α), monocyte chemoattractant protein 4 (MCP-4), and vascular endothelial growth factor (VEGF) in 40 patients hospitalized with acute lower respiratory tract infections (LRTI). The cytokines contribute to the pathogenesis of several inflammatory respiratory diseases, indicating a potential as markers for LRTI...
November 16, 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27854115/an-investigation-into-respiratory-tract-viruses-in-children-with-acute-lower-respiratory-tract-infection-or-wheezing
#13
Demet Dabaniyasti, Fahriye Eksi, Özlem Keskin, Mehmet Y Özkars, Tekin Karsligil, Iclal Balci
BACKGROUND: This study aimed to determine the frequencies of respiratory tract viruses in patient (acute lower respiratory tract infection (LRTI) or wheezing) and control (history of asthma without symptoms) groups. METHODS: Using multiplex-PCR, respiratory tract viruses were investigated in the respiratory tract specimens from patient and control groups followed in the Pediatric Clinic. RESULTS: The viruses detected in the patient and control groups (p=0...
November 17, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27851998/clinical-and-molecular-features-of-adenovirus-type-2-3-and-7%C3%A2-infections-in-children-in-an-outbreak-in-taiwan-2011
#14
M-R Lin, S-L Yang, Y-N Gong, C-C Kuo, C-H Chiu, C-J Chen, Y-C Hsieh, C-Y Kuo, C-W Fang, K-C Tsao, Y-C Huang
OBJECTIVES: We studied paediatric patients with human adenovirus (HAdV) infection during the 2011 outbreak in northern Taiwan to define the clinical features of different HAdV genotypes in children. METHODS: Between January and December 2011, 637 patients <19 years of age exhibited culture-confirmed adenoviral infection in Chang Gung Memorial Hospital, and provided specimens available for genotyping by multiplex real-time PCR. Clinical data were collected retrospectively...
November 13, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27762515/a-cross-sectional-cohort-analyses-assessing-response-to-levosalbutamol-bronchodilatory-cough-formulations-in-outpatient-community-settings-of-india-bus-analyses
#15
A Vora, Amit Bhargava
INTRODUCTION: Cough is significant health problem with greater implication for impaired quality of life. Acute and chronic cough due to infective (viral/bacterial), allergic conditions or bronchial asthma including cough variant asthma are often treated with combination of mucolytics, expectorants and bronchodilators. Bronchodilators reduces cough sensitivity, promotes clearance of cough secretions while reducing protrusive inflammatory mediator release. AIMS AND OBJECTIVES: To further understand the clinical utility and safety of Bronchodilatory cough formulations (BCF) containing Levosalbutamol in real world settings...
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27753796/etiology-of-acute-respiratory-infections-in-infants-a-prospective-birth-cohort-study
#16
Prawin Kumar, Guruprasad R Medigeshi, Vishnu S Mishra, Mojahidul Islam, Shivani Randev, Aparna Mukherjee, Rama Chaudhry, Arti Kapil, Kana Ram Jat, Rakesh Lodha, Sushil K Kabra
BACKGROUND: There is paucity of studies on etiology of acute respiratory infections (ARI) in infants. The objective of this study is to document incidence and etiology of ARI in infants, their seasonal variability and association of clinical profile with etiology. METHODS: A birth cohort was followed for the first year of life; for each episode of ARI, nasopharyngeal aspirates were collected to identify the causative respiratory virus(es) using multiplex real-time polymerase chain reaction assay...
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27751779/revision-ligament-reconstruction-tendon-interposition-for-trapeziometacarpal-arthritis-a-case-control-investigation
#17
Anita Sadhu, Ryan P Calfee, Andre Guthrie, Lindley B Wall
PURPOSE: To test the null hypothesis that there is no difference in patient-reported and objective outcomes of revision ligament reconstruction and tendon interposition (LRTI) compared with primary LRTI. METHODS: This case-control investigation enrolled 10 patients who had undergone revision LRTI at a tertiary care center. All patients had previously undergone primary trapeziectomy with LRTI. Patients with a minimum of 2 years' follow-up were eligible. All patients completed an in-office study evaluation...
December 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27737646/maternal-vitamin-d-supplementation-during-pregnancy-and-lactation-to-prevent-acute-respiratory-infections-in-infancy-in-dhaka-bangladesh-mdari-trial-protocol-for-a-prospective-cohort-study-nested-within-a-randomized-controlled-trial
#18
Shaun K Morris, Lisa G Pell, Mohammed Ziaur Rahman, Michelle C Dimitris, Abdullah Mahmud, M Munirul Islam, Tahmeed Ahmed, Eleanor Pullenayegum, Tahmid Kashem, Shaila S Shanta, Jonathan Gubbay, Eszter Papp, Michelle Science, Stanley Zlotkin, Daniel E Roth
BACKGROUND: Early infancy is a high-risk period for severe acute respiratory infection (ARI), particularly in low-income countries with resource-limited health systems. Lower respiratory tract infection (LRTI) is commonly preceded by upper respiratory infection (URTI), and often caused by respiratory syncytial virus (RSV), influenza and other common community-acquired viral pathogens. Vitamin D status is a candidate modifiable early-life determinant of the host antiviral immune response and thus may influence the risk of ARI-associated morbidity in high-risk populations...
October 13, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27695990/functional-and-genetic-predisposition-to-rhinovirus-lower-respiratory-tract-infections-in-prematurely-born-infants
#19
Simon B Drysdale, Mireia Alcazar, Theresa Wilson, Melvyn Smith, Mark Zuckerman, Hennie M Hodemaekers, Riny Janssen, Louis Bont, Sebastian L Johnston, Anne Greenough
: Term born infants are predisposed to human rhinovirus (HRV) lower respiratory tract infections (LRTI) by reduced neonatal lung function and genetic susceptibility. Our aim was to investigate whether prematurely born infants were similarly predisposed to HRV LRTIs or any other viral LRTIs. Infants born less than 36 weeks of gestational age were recruited. Prior to neonatal/maternity unit discharge, lung function (functional residual capacity by helium gas dilution and multiple breath washout, lung clearance index and compliance (Crs), and resistance (Rrs) of the respiratory system) was assessed and DNA samples assessed for eight single nucleotide polymorphisms (SNPs) in seven genes: ADAM33, IL10, MMP16 NFκB1A,SFTPC, VDR, and NOS2A...
December 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27670781/host-cytoskeleton-in-respiratory-syncytial-virus-assembly-and-budding
#20
Shadi Shahriari, James Gordon, Reena Ghildyal
Respiratory syncytial virus (RSV) is one of the major pathogens responsible for lower respiratory tract infections (LRTI) in young children, the elderly, and the immunosuppressed. Currently, there are no antiviral drugs or vaccines available that effectively target RSV infections, proving a significant challenge in regards to prevention and treatment. An in-depth understanding of the host-virus interactions that underlie assembly and budding would inform new targets for antiviral development.Current research suggests that the polymerised form of actin, the filamentous or F-actin, plays a role in RSV assembly and budding...
September 26, 2016: Virology Journal
keyword
keyword
78831
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"