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https://www.readbyqxmd.com/read/29315642/human-respiratory-syncytial-virus-load-normalized-by-cell-quantification-as-predictor-of-acute-respiratory-tract-infection
#1
Miriam Gómez-Novo, José A Boga, Marta E Álvarez-Argüelles, Susana Rojo-Alba, Ana Fernández, María J Menéndez, María de Oña, Santiago Melón
OBJECTIVES: Human respiratory syncytial virus (HRSV) is a common cause of respiratory infections. The main objective is to analyze the prediction ability of viral load of HRSV normalized by cell number in respiratory symptoms. STUDY DESIGN: A prospective, descriptive and analytical study was performed. From 7307 respiratory samples processed between December 2014 to April 2016, 1019 HRSV-positive samples, were included in this study. Low respiratory tract infection was present in 729 patients (71...
January 5, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29314779/respiratory-viral-infections-in-infancy-and-school-age-respiratory-outcomes-and-healthcare-costs
#2
Victoria MacBean, Simon B Drysdale, Muska N Yarzi, Janet L Peacock, Gerrard F Rafferty, Anne Greenough
OBJECTIVES: To determine the impact of viral lower respiratory tract infections (LRTIs) in infancy including rhinovirus (RV) and infancy respiratory syncytial virus (RSV), on school age pulmonary function and healthcare utilization in prematurely born children. WORKING HYPOTHESIS: School age respiratory outcomes would be worse and healthcare utilization greater in children who had viral LRTIs in infancy. STUDY DESIGN: Prospective study. SUBJECT SELECTION: A cohort of prematurely born children who had symptomatic LRTIs during infancy documented, was recalled...
January 4, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29285648/bacteria-from-bronchoalveolar-lavage-fluid-from-children-with-suspected-chronic-lower-respiratory-tract-infection-results-from-a-multi-center-cross-sectional-study-in-spain
#3
Amparo Escribano Montaner, Juan García de Lomas, José Ramón Villa Asensi, Oscar Asensio de la Cruz, Olga de la Serna Blázquez, Mikel Santiago Burruchaga, Pedro Mondéjar López, Alba Torrent Vernetta, Yang Feng, Melissa K Van Dyke, Janet Reyes, Pilar Garcia-Corbeira, Carla A Talarico
This cross-sectional study assessed the prevalence of bacteria isolated from Spanish children with suspected chronic lower respiratory tract infection (LRTI) for whom bronchoalveolar lavage (BAL) was indicated. BAL fluid (BALF) was collected from 191 children (aged ≥ 6 months to < 6 years, with persistent or recurrent respiratory symptoms, non-responders to usual treatment) and cultured. Nasopharyngeal swabs (NPSs) were also obtained and cultured to assess concordance of BALF and NPS findings in the same patient...
December 29, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29282255/pregnancy-exposure-to-air-pollution-and-early-childhood-respiratory-health-in-the-norwegian-mother-and-child-cohort-study-moba
#4
Christian Madsen, Siri Eldevik Haberg, Maria C Magnus, Geir Aamodt, Hein Stigum, Stephanie J London, Wenche Nystad, Per Nafstad
OBJECTIVES: It is unclear whether maternal air pollution exposure during pregnancy induces changes in the developing respiratory system of a child and whether it has consequences for respiratory health in early childhood. We investigated associations between exposure to moderate levels of air pollution during pregnancy and early childhood lower respiratory tract infections (LRTI) and wheezing. METHODS: This study used a subgroup of 17 533 participants in the Norwegian Mother and Child Cohort Study...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29273482/a-novel-host-protein-assay-outperforms-routine-parameters-for-distinguishing-between-bacterial-and-viral-lower-respiratory-tract-infections
#5
Michal Stein, Shelly Lipman-Arens, Kfir Oved, Asi Cohen, Ellen Bamberger, Roy Navon, Olga Boico, Tom Friedman, Liat Etshtein, Meital Paz, Tanya M Gottlieb, Or Kriger, Yura Fonar, Ester Pri-Or, Renata Yacobov, Yaniv Dotan, Amit Hochberg, Moti Grupper, Irina Chistyakov, Israel Potasman, Isaac Srugo, Eran Eden, Adi Klein
Bacterial and viral lower respiratory tract infections (LRTIs) are often clinically indistinguishable, leading to antibiotic overuse. We compared the diagnostic accuracy of a new assay that combines 3 host-biomarkers (TRAIL, IP-10, CRP) with parameters in routine use to distinguish bacterial from viral LRTIs. Study cohort included 184 potentially eligible pediatric and adult patients. Reference standard diagnosis was based on adjudication by an expert panel following comprehensive clinical and laboratory investigation (including respiratory PCRs)...
November 24, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29246125/low-birth-weight-contributed-to-increased-serum-il-6-levels-in-infantile-respiratory-syncytial-virus-infection
#6
Yuan-Jian Sheng, Shan-Shan Xu, Xue-Jing Li, Jin-Ling Liu, Xi-Ling Wu, Xue-Feng Xu
BACKGROUND: To evaluate the role of serum cytokines in the pathogenesis of respiratory syncytial virus (RSV) infection in infants with low birth weight (LBW). METHODS: A prospective observational study was performed, and hospitalized children with lower respiratory tract infection (LRTI) were recruited. Three hundred fifty-eight patients < 1 year met the inclusion criteria: 116 patients had only RSV infection (RSV group); 242 patients had no RSV or other specific pathogen (non-RSV group)...
December 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29236038/adverse-effects-of-amoxicillin-for-acute-lower-respiratory-tract-infection-in-primary-care-secondary-and-subgroup-analysis-of-a-randomised-clinical-trial
#7
Meera Tandan, Akke Vellinga, Robin Bruyndonckx, Paul Little, Theo Verheij, Chris C Butler, Herman Goossens, Samuel Coenen
A European placebo-controlled trial of antibiotic treatment for lower respiratory tract infection (LRTI) conducted in 16 primary care practices networks recruited participants between November 2007 and April 2010, and found adverse events (AEs) occurred more often in patients prescribed amoxicillin compared to placebo. This secondary analysis explores the causal relationship and estimates specific AEs (diarrhoea, nausea, rash) due to amoxicillin treatment for LRTI, and if any subgroup is at increased risk of any or a specific AE...
December 13, 2017: Antibiotics
https://www.readbyqxmd.com/read/29224300/-etiological-analysis-and-establishment-of-a-discriminant-model-for-lower-respiratory-tract-infections-in-hospitalized-patients
#8
Y S Chen, X H Lin, H R Li, Z D Hua, M Q Lin, W S Huang, T Yu, H Y Lyu, W P Mao, Y Q Liang, X R Peng, S J Chen, H Zheng, S Q Lian, X L Hu, X Q Yao
Objective: To analyze the pathogens of lower respiratory tract infection(LRTI) including bacterial, viral and mixed infection, and to establish a discriminant model based on clinical features in order to predict the pathogens. Methods: A total of 243 hospitalized patients with lower respiratory tract infections were enrolled in Fujian Provincial Hospital from April 2012 to September 2015. The clinical data and airway (sputum and/or bronchoalveolar lavage) samples were collected. Microbes were identified by traditional culture (for bacteria), loop-mediated isothermal amplification(LAMP) and gene sequencing (for bacteria and atypical pathogen), or Real-time quantitative polymerase chain reaction (Real-time PCR)for viruses...
December 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29173358/bacterial-etiology-of-lower-respiratory-tract-infections-and-their-antimicrobial-susceptibility
#9
Maduakor Uzoamaka, Onyemelukwe Ngozi, Ogboi Sonny Johnbull, Ohanu Martin
BACKGROUND: Lower respiratory tract infection (LRTI) is one of the common major health problems in Nigeria causing morbidity and mortality. The study was conducted to determine the current trends of bacterial etiology of LRTIs among patients who attended the University of Nigeria Teaching Hospital (UNTH) and their antimicrobial susceptibility profile with special interest on pandrug resistance. MATERIALS AND METHODS: The study was conducted between February 2014 and June 2016 in the bacteriology laboratory of UNTH...
November 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29167839/early-life-exposure-to-indoor-air-pollution-or-tobacco-smoke-and-lower-respiratory-tract-illness-and-wheezing-in-african-infants-a-longitudinal-birth-cohort-study
#10
Aneesa Vanker, Whitney Barnett, Lesley Workman, Polite M Nduru, Peter D Sly, Robert P Gie, Heather J Zar
Background: Indoor air pollution (IAP) and environmental tobacco smoke (ETS) are associated with lower respiratory tract illness (LRTI) or wheezing in children. However, the effect of the timing of these exposures, specifically antenatal versus postnatal, and of alternate fuel sources such as the increasingly used volatile organic compounds have not been well studied. We longitudinally investigated the effect of antenatal or postnatal IAP and ETS on LRTI or wheezing prevalence and severity in African infants...
November 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29167296/predictors-of-pneumonia-in-lower-respiratory-tract-infections-3c-prospective-cough-complication-cohort%C3%A2-study
#11
Michael Moore, Beth Stuart, Paul Little, Sue Smith, Matthew J Thompson, Kyle Knox, Anne van den Bruel, Mark Lown, David Mant
The aim was to aid diagnosis of pneumonia in those presenting with lower respiratory tract symptoms in routine primary care.A cohort of 28 883 adult patients with acute cough attributed to lower respiratory tract infections (LRTIs) was recruited from 5222 UK practices in 2009-13. Symptoms, signs and treatment were recorded at presentation and subsequent events followed-up for 30 days by chart review. The predictive value of patient characteristics, presenting symptoms and clinical findings for the diagnosis of pneumonia in the first 7 days was established...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29164489/antimicrobial-stewardship-opportunities-in-critically-ill-patients-with-gram-negative-lower-respiratory-tract-infections-a-multicenter-cross-sectional-analysis
#12
Kimberly C Claeys, Evan J Zasowski, Trang D Trinh, Abdalhamid M Lagnf, Susan L Davis, Michael J Rybak
INTRODUCTION: Lower respiratory tract infections (LRTIs) are a major cause of morbidity and death. Because of changes in how LRTIs are defined coupled with the increasing prevalence of drug resistance, there is a gap in knowledge regarding the current burden of antimicrobial use for Centers for Disease Control and Prevention (CDC)-defined LRTIs. We describe the infection characteristics, antibiotic consumption, and clinical and economic outcomes of patients with Gram-negative (GN) LRTIs treated in intensive care units (ICUs)...
November 21, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29164144/intensive-care-unit-patients-with-lower-respiratory-tract-nosocomial-infections-the-enirris-project
#13
Gennaro De Pascale, Otavio T Ranzani, Saad Nseir, Jean Chastre, Tobias Welte, Massimo Antonelli, Paolo Navalesi, Eugenio Garofalo, Andrea Bruni, Luis Miguel Coelho, Szymon Skoczynski, Federico Longhini, Fabio Silvio Taccone, David Grimaldi, Helmut J F Salzer, Christoph Lange, Filipe Froes, Antoni Artigas, Emili Díaz, Jordi Vallés, Alejandro Rodríguez, Mauro Panigada, Vittoria Comellini, Luca Fasano, Paolo M Soave, Giorgia Spinazzola, Charles-Edouard Luyt, Francisco Alvarez-Lerma, Judith Marin, Joan Ramon Masclans, Davide Chiumello, Angelo Pezzi, Marcus Schultz, Hafiz Mohamed, Menno Van Der Eerden, Roger A S Hoek, D A M P J Gommers, Marta Di Pasquale, Rok Civljak, Marko Kutleša, Matteo Bassetti, George Dimopoulos, Stefano Nava, Fernando Rios, Fernando G Zampieri, Pedro Povoa, Lieuwe D Bos, Stefano Aliberti, Antoni Torres, Ignacio Martín-Loeches
The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29162852/predicting-nosocomial-lower-respiratory-tract-infections-by-a-risk-index-based-system
#14
Yong Chen, Xue Shan, Jingya Zhao, Xuelin Han, Shuguang Tian, Fangyan Chen, Xueting Su, Yansong Sun, Liuyu Huang, Hajo Grundmann, Hongyuan Wang, Li Han
Although belonging to one of the most common type of nosocomial infection, there was currently no simple prediction model for lower respiratory tract infections (LRTIs). This study aims to develop a risk index based system for predicting nosocomial LRTIs based on data from a large point-prevalence survey. Among the 49328 patients included, the prevalence of nosocomial LRTIs was 1.70% (95% confidence interval [CI], 1.64% to 1.76%). The areas under the receiver operating characteristic (ROC) curve for logistic regression and fisher discriminant analysis were 0...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29157959/the-risk-of-lower-respiratory-tract-infection-following-influenza-virus-infection-a-systematic-and-narrative-review
#15
Ryan E Malosh, Emily T Martin, Justin R Ortiz, Arnold S Monto
BACKGROUND: Lower respiratory tract infections (LRTI) are a major cause of morbidity and mortality worldwide, particularly in young children and older adults. Influenza is known to cause severe disease but the risk of developing LRTI following influenza virus infection in various populations has not been systematically reviewed. Such data are important for estimating the impact specific influenza vaccine programs would have on LRTI outcomes in a community. We sought to review the published literature to determine the risk of developing LRTI following an influenza virus infection in individuals of any age...
November 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29153553/effectiveness-of-an-early-switch-from-intravenous-to-oral-antimicrobial-therapy-for-lower-respiratory-tract-infection-in-patients-with-severe-motor-intellectual-disabilities
#16
Masaru Kawamura, Takayuki Hoshina, Masato Ogawa, Takato Nakamoto, Koichi Kusuhara
An early switch from intravenous to oral antimicrobial therapy is useful for reducing the duration of the hospitalization in adult patients with community acquired-pneumonia, whereas the efficacy of switch therapy for pediatric patients with community acquired (CA)-lower respiratory tract infection (LRTI) is uncertain. The aim of this study is to investigate the efficacy of switch therapy for LRTI in patients with severe motor intellectual disabilities (SMID). This retrospective study was performed on 92 patients with SMID who were admitted to the Department of Pediatrics at the Hospital of University of Occupational and Environmental Health, Japan from April 1, 2010 to March 31, 2017 for the suspicion of bacterial LRTI and were initially treated with an intravenous antimicrobial agent...
November 16, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29136326/dna-based-testing-in-lung-transplant-recipients-with-suspected-non-viral-lower-respiratory-tract-infection-a-prospective-observational-study
#17
Nora Drick, Benjamin Seeliger, Mark Greer, Benjamin A Bollmann, Stefan Ziesing, Tobias Welte, Jens Gottlieb
BACKGROUND: Non-viral lower respiratory tract infections (LRTI) are common among lung transplant (LTx) recipients with increased mortality. Early pathogen identification is crucial to guide therapy and avoid adverse events. Results from cultures may require up to 72 hours. Multiplex polymerase chain reaction assay (PCR) may allow faster pathogen identification, but its utility in LTx recipients with suspected non-viral LRTI remains unclear. METHODS: In a prospective open-label observational trial, LTx recipients presenting with suspected LRTI received bronchoscopy with bronchoalveolar lavage (BAL)...
November 14, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29128553/pediatric-hematopoietic-cell-transplant-patients-who-survive-critical-illness-frequently-have-significant-but-recoverable-decline-in-functional-status
#18
M S Zinter, R Holubkov, M A Steurer, C C Dvorak, C N Duncan, A Sapru, R F Tamburro, P S McQuillen, M M Pollack
BACKGROUND: The number of pediatric hematopoietic cell transplant (HCT) patients who survive pediatric intensive care unit (PICU) admission is increasing, yet little is known about their functional morbidity after PICU discharge. We hypothesized that relative to controls, pediatric HCT patients who survive PICU admission would have greater rates of new functional morbidity at the time of PICU discharge, and only a minority of these patients would return to their functional baseline by the end of the hospitalization...
November 8, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29118126/respiratory-syncytial-virus-rsv-targeting-the-g-protein-provides-a-new-approach-for-an-old-problem
#19
Ralph A Tripp, Ultan F Power, Peter J M Openshaw, Lawrence M Kauvar
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) annually affecting >2 million children in the US <5 years old. In the elderly (>65 years old), RSV results in ∼175,000 hospitalizations annually in the US with worldwide incidence ∼34 million. There is no approved RSV vaccine and treatments are limited. Recently, a Phase 3 trial in the elderly using a recombinant RSV F protein vaccine failed to meet its efficacy objectives, namely prevention of moderate-to-severe RSV-associated LRTI and reduced incidence of acute respiratory disease...
November 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29113779/hospital-acquired-lower-respiratory-tract-infections-among-high-risk-hospitalized-patients-in-a-tertiary-care-teaching-hospital-in-china-an-economic-burden-analysis
#20
Tianyuan Yan, Yingxia Li, Yu Sun, Haiyan Wang, Jingna Wang, Weili Wang, Yunhong Liu, Xiaohui Wu, Shuhui Wang
BACKGROUND: Data on the economic burden of hospital-acquired lower respiratory tract infection (LRTI) among high risk hospitalized patients are lacking in China. This study aims to fill this knowledge gap. METHODS: We used a prospective matched cohort design, comparing patients with LRTIs and 1:1 matched patients without LRTIs. Study period was from January 2013 to December 2015 analyzing inpatients from high risk wards - intensive care unit (ICU), dialysis, hematology, etc...
November 4, 2017: Journal of Infection and Public Health
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