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https://www.readbyqxmd.com/read/28648408/nhsla-litigation-in-hip-fractures-lessons-learnt-from-nhsla-data
#1
Joseph Ring, Christopher Talbot, Charlotte Cross, Kunal Hinduja
Hip fractures are a major cause of trauma related death, usually occurring in vulnerable elderly patients. There are an estimated 70,000 hip fractures in the UK per year with numbers set to rise. The estimated annual cost to the healthcare economy is in the region of £2 billion. A 17-year review examining litigation related to hip fractures was undertaken. Under a freedom of information request, data was obtained relating to all orthopaedic claims made to the NHS Litigation Authority (NHSLA) between 1995 and 2012...
June 19, 2017: Injury
https://www.readbyqxmd.com/read/28631699/-lower-extremity-venous-diseases-in-primary-knee-osteoarthritis
#2
O M Lesnyak, E V Zubareva, M G Goncharova, D M Maksimov
AIM: To establish a possible association between knee osteoarthritis (OA) and lower extremity venous diseases ((LEVDs) on the basis of thorough clinical and instrumental studies. SUBJECTS AND METHODS: A case-control study recruiting 40-60-year-old women was conducted. A study group included 85 women with knee OA; a control group consisted of 50 women without this condition. The patients of both groups underwent assessment of complaints and goal-directed objective examination to identify joint diseases and chronic LEVDs, knee X-ray study, and duplex scanning of the lower extremity veins...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28631145/biaxial-mechanical-properties-of-bovine-jugular-venous-valve-leaflet-tissues
#3
Hsiao-Ying Shadow Huang, Jiaqi Lu
Venous valve incompetence has been implicated in diseases ranging from chronic venous insufficiency (CVI) to intracranial venous hypertension. However, while the mechanical properties of venous valve leaflet tissues are central to CVI biomechanics and mechanobiology, neither stress-strain curves nor tangent moduli have been reported. Here, equibiaxial tensile mechanical tests were conducted to assess the tangent modulus, strength and anisotropy of venous valve leaflet tissues from bovine jugular veins. Valvular tissues were stretched to 60% strain in both the circumferential and radial directions, and leaflet tissue stress-strain curves were generated for proximal and distal valves (i...
June 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28626000/baiap3-a-c2-domain-containing-munc13-protein-controls-the-fate-of-dense-core-vesicles-in-neuroendocrine-cells
#4
Xingmin Zhang, Shan Jiang, Kelly A Mitok, Lingjun Li, Alan D Attie, Thomas F J Martin
Dense-core vesicle (DCV) exocytosis is a SNARE (soluble N-ethylmaleimide-sensitive fusion attachment protein receptor)-dependent anterograde trafficking pathway that requires multiple proteins for regulation. Several C2 domain-containing proteins are known to regulate Ca(2+)-dependent DCV exocytosis in neuroendocrine cells. In this study, we identified others by screening all (∼139) human C2 domain-containing proteins by RNA interference in neuroendocrine cells. 40 genes were identified, including several encoding proteins with known roles (CAPS [calcium-dependent activator protein for secretion 1], Munc13-2, RIM1, and SYT10) and many with unknown roles...
June 16, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28625189/influence-of-early-maladaptive-schemas-depression-and-anxiety-on-the-intensity-of-self-reported-cognitive-complaint-in-older-adults-with-subjective-cognitive-decline
#5
Caroline Tandetnik, Thierry Hergueta, Philippe Bonnet, Bruno Dubois, Catherine Bungener
BACKGROUND: Subjective cognitive decline (SCD) designates a self-reported cognitive decline despite preserved cognitive abilities. This study aims to explore, in older adults with SCD, the association between intensity of self-reported cognitive complaint and psychological factors including Young's early maladaptive schemas (EMSs) (i.e. enduring cognitive structures giving rise to beliefs about oneself and the world), as well as depression and anxiety. METHODS: Seventy-six subjects (69...
June 19, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28623986/double-prepuncture-as-a-valuable-adjunctive-technique-for-complex-endovenous-ablation
#6
Scarlett Hao, Samantha Cox, Thomas S Monahan, Rajabrata Sarkar
OBJECTIVE: The objective of this study was to characterize the technique and to report the results of double prepuncture used during complex radiofrequency ablation (RFA) in cases of treating multiple incompetent veins or encountering focal obstruction to catheter advancement. METHODS: A double prepuncture technique was applied in patients requiring endovascular ablation of multiple veins and patients with great saphenous vein cannulation failure. We treated 13 limbs in 12 patients during a 24-month period with RFA in which the double prepuncture technique was used...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28623983/clinical-presentation-of-women-with-pelvic-source-varicose-veins-in-the-perineum-as-a-first-step-in-the-development-of-a-disease-specific-patient-assessment-tool
#7
Kathleen Gibson, Renee Minjarez, Brian Ferris, Moni Neradilek, Matthew Wise, Julianne Stoughton, Mark Meissner
OBJECTIVE: Pelvic venous incompetence can cause symptomatic varicose veins in the perineum, buttock, and thigh. Presentation, symptom severity, and response to treatment of pelvic source varicose veins are not well defined. Currently available tools to measure the severity of lower extremity venous disease and its effects on quality of life may be inadequate to assess disease severity in these patients. The purpose of this study was to evaluate the histories, demographics, and clinical presentations of women with pelvic source varicose veins and to compare these data to a population of women with nonpelvic source varicose veins...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28621727/insights-into-the-experiences-of-treatment-for-an-eating-disorder-in-men-a-qualitative-study-of-autobiographies
#8
Priyanka Thapliyal, Deborah Mitchison, Phillipa Hay
Eating disorders are increasingly recognized as a problem for men but help-seeking is low and little is known about their treatment experiences. This paper sought to determine the treatment experiences of men who have suffered from an eating disorder using autobiographical data. Inclusion criteria were autobiographies of men who had experienced an eating disorder and sought any form of treatment for this, written in the English language, published between 1995 and 2015, and available for purchase in 2016. The search resulted in six books that were thematically analyzed...
June 16, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28620164/biodistribution-and-residence-time-of-adenovector-serotype-5-in-normal-and-immunodeficient-mice-and-rats-detected-with-bioluminescent-imaging
#9
Qiang Liu, Shuya Zhou, Changfa Fan, Weijin Huang, Qianqian Li, Susu Liu, Xi Wu, Baowen Li, Youchun Wang
As concerns increase about adenovirus type 5 (Ad5) being a safe gene transfer vector, it is important to evaluate its distribution, residence time, and possible toxicity in immunodeficient populations. To characterize the potential risk associated with different Ad5 vector delivery modes, we used immunocompetent and immunodeficient Rag2 (-/-) animals to establish mouse and rat models that could be monitored with bioluminescent imaging following intramuscular or intravascular infection with an engineered replication-incompetent Ad5 virus carrying the firefly luciferase gene (Ad5-Fluc)...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28617518/tibiofemoral-instability-after-primary-total-knee-arthroplasty-posterior-stabilized-implants-for-obese-patients
#10
Ata Can, Fahri Erdogan, Ayse Ovul Erdogan
Tibiofemoral instability is a common complication after total knee arthroplasty (TKA), accounting for up to 22% of all revision procedures. Instability is the second most common cause of revision in the first 5 years after primary TKA. In this study, 13 knees with tibiofemoral instability after TKA were identified among 693 consecutive primary TKA procedures. Patient demographics, body mass index, clinical symptoms, previous deformity, previous knee surgery, complications, interval between index TKA and first tibiofemoral instability, causes of instability, and interval between index TKA and revision TKA were retrospectively reviewed...
June 15, 2017: Orthopedics
https://www.readbyqxmd.com/read/28605529/the-genomic-impact-of-gene-retrocopies-what-have-we-learned-from-comparative-genomics-population-genomics-and-transcriptomic-analyses
#11
Claudio Casola, Esther Betrán
Gene duplication is a major driver of organismal evolution. Gene retroposition is a mechanism of gene duplication whereby a gene's transcript is used as a template to generate retroposed gene copies, or retrocopies. Intriguingly, the formation of retrocopies depends upon the enzymatic machinery encoded by retrotransposable elements, genomic parasites occurring in the majority of eukaryotes. Most retrocopies are depleted of the regulatory regions found upstream of their parental genes; therefore, they were initially considered transcriptionally incompetent gene copies, or retropseudogenes...
June 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28603073/rapid-prenatal-diagnosis-of-aneuploidy-for-chromosomes-21-18-13-x-and-y-using-segmental-duplication-quantitative-fluorescent-pcr-sd-qf-pcr
#12
Lei Sun, Zuqian Fan, Ju Long, Xunjin Weng, Weijun Tang, Wanrong Pang
BACKGROUND: In our previous studies, the rapid diagnosis of aneuploidy has been achieved using the segmental duplication molecular markers-based SD-QF-PCR technique. However, it is also insufficient due to the drawbacks including less detection loci and incompetence in single-tube detection. METHODS: In this paper, we developed 13 new segmental duplications as molecular markers, as well as designed 13 pairs of primers and 1 fluorescence-labeled universal primer, which could detect chromosome aneuploidies in one PCR tube...
June 9, 2017: Gene
https://www.readbyqxmd.com/read/28600291/sphingosine-1-phosphate-lyase-enhances-the-activation-of-ikk%C3%AE%C2%B5-to-promote-type-i-ifn-mediated-innate-immune-responses-to-influenza-a-virus-infection
#13
Madhuvanthi Vijayan, Chuan Xia, Yul Eum Song, Hanh Ngo, Caleb J Studstill, Kelly Drews, Todd E Fox, Marc C Johnson, John Hiscott, Mark Kester, Stephen Alexander, Bumsuk Hahm
Sphingosine 1-phosphate (S1P) lyase (SPL) is an intracellular enzyme that mediates the irreversible degradation of the bioactive lipid S1P. We have previously reported that overexpressed SPL displays anti-influenza viral activity; however, the underlying mechanism is incompletely understood. In this study, we demonstrate that SPL functions as a positive regulator of IKKε to propel type I IFN-mediated innate immune responses against viral infection. Exogenous SPL expression inhibited influenza A virus replication, which correlated with an increase in type I IFN production and IFN-stimulated gene accumulation upon infection...
June 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28592543/mapping-of-transcription-termination-within-the-s-segment-of-sfts-phlebovirus-facilitated-the-generation-of-nss-deletant-viruses
#14
Benjamin Brennan, Veronica V Rezelj, Richard M Elliott
SFTS phlebovirus (severe fever with thrombocytopenia syndrome virus; SFTSV) is an emerging tick-borne bunyavirus that was first reported in China in 2009. Here we report the generation of a recombinant SFTSV (rHB29NSsKO) that cannot express the viral non-structural protein (NSs) upon infection of cells in culture. We show that rHB29NSsKO replication kinetics are greater in interferon (IFN)-incompetent cells and that the virus is unable to suppress IFN induced in response to viral replication. The data confirm for the first time in the context of virus infection that NSs acts as a virally encoded IFN antagonist and that NSs is dispensable for virus replication...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28592537/role-of-autophagy-in-the-hiv-1-matrix-protein-p17-driven-lymphangiogenesis
#15
Pietro Mazzuca, Stefania Marsico, Kai Schulze, Stefania Mitola, Marina C Pils, Cinzia Giagulli, Carlos A Guzman, Arnaldo Caruso, Francesca Caccuri
AIDS-related lymphomas (ARLs) are expected to increase in the future since combined antiretroviral therapy (cART) enhances the life expectancy of HIV-1-infected (HIV(+)) patients, but does not affect the occurrence of ARLs to the same extent as of other tumors. Lymphangiogenesis is essential in supporting growth and metastatic spreading of ARLs. HIV-1 does not infect the neoplastic B cells, but HIV-1 proteins have been hypothesized to play a key role in sustaining a pro-lymphangiogenic microenvironment in lymphoid organs...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28592193/permanent-chronotropic-impairment-after-closure-of-atrial-or-ventricular-septal-defect
#16
Johan Heiberg, Camilla Nyboe, Vibeke E Hjortdal
OBJECTIVES: Atrial and ventricular septal defects are commonly closed surgically with low rates of post-operative morbidity, and the long-term outcome has widely been described as benign. Nevertheless, there is an increasing understanding of late morbidity, and the possibility of postoperative chronotropic impairment is continuously questioned. Furthermore, potentially abnormal chronotropic responses may be associated with the recently demonstrated overrepresentation of late arrhythmias...
June 8, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28590895/a-qualitative-case-study-of-smartphone-connected-hearing-aids-influences-on-patients-clinicians-and-patient-clinician-interactions
#17
Stella L Ng, Shanon Phelan, MaryAnn Leonard, Jason Galster
BACKGROUND: Innovations in hearing aid technology influence clinicians and individuals who use hearing aids. Little research, to date, explains the innovation adoption experiences and perspectives of clinicians and patients, which matter to a field like audiology, wherein technology innovation is constant. By understanding clinician and patient experiences with such innovations, the field of audiology may develop technologies and ways of practicing in a manner more responsive to patients' needs, and attentive to society's influence...
June 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28590245/collagen-induces-activation-of-ddr1-through-lateral-dimer-association-and-phosphorylation-between-dimers
#18
Victoria Juskaite, David S Corcoran, Birgit Leitinger
The collagen-binding receptor tyrosine kinase DDR1 (discoidin domain receptor 1) is a drug target for a wide range of human diseases, but the molecular mechanism of DDR1 activation is poorly defined. Here we co-expressed different types of signalling-incompetent DDR1 mutants ('receiver') with functional DDR1 ('donor') and demonstrate phosphorylation of receiver DDR1 by donor DDR1 in response to collagen. Making use of enforced covalent DDR1 dimerisation, which does not affect receptor function, we show that receiver dimers are phosphorylated in trans by the donor; this process requires the kinase activity of the donor but not that of the receiver...
June 7, 2017: ELife
https://www.readbyqxmd.com/read/28588720/synergistic-activity-of-the-histone-deacetylase-inhibitor-trichostatin-a-and-the-proteasome-inhibitor-ps-341-against-taxane-resistant-ovarian-cancer-cell-lines
#19
Xin Jin, Yong Fang, Yi Hu, Jing Chen, Wei Liu, Gang Chen, Mei Gong, Peng Wu, Tao Zhu, Shixuan Wang, Jianfeng Zhou, Hui Wang, Ding Ma, Kezhen Li
Although a combination of platinum- and taxane-based chemotherapy is recommended for at least 70% patients with ovarian cancer as treatment subsequent to surgery, the initial response to the chemotherapy is not durable and tumors become resistant. Histone deacetylase and proteasome inhibitors are novel therapeutic agents. However, the moderate antitumoral effect of the inhibitors has restricted their clinical use when used as single agents. The aim of the present study was to investigate the synergistic activity of trichostatin A (TSA) and PS-341 in ovarian cancer cells, along with the investigation of the molecular mechanisms of taxane resistance...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28580713/mitral-valve-prolapse-and-marfan-syndrome
#20
REVIEW
Amitabh Thacoor
Marfan syndrome is a multisystemic genetic condition affecting connective tissue. It carries a reduced life expectancy, largely dependent on cardiovascular complications. More common cardiac manifestations such as aortic dissection and aortic valve incompetence have been widely documented in the literature. Mitral valve prolapse (MVP), however, has remained poorly documented. This article aims at exploring the existing literature on the pathophysiology and diagnosis of MVP in patients with Marfan syndrome, defining its current management and outlining the future developments surrounding it...
June 5, 2017: Congenital Heart Disease
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