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https://www.readbyqxmd.com/read/29778302/impact-of-low-anorectal-malformation-on-parenting-stress-a-mixed-method-study
#1
Helena Wigander, Maria Öjmyr-Joelsson, Björn Frenckner, Tomas Wester, Margret Nisell
The purpose of this study was to investigate parenting stress among parents of children with low ARM. STUDY AIMS: 1) Compare parenting stress among parents of children with low ARM, with parents of healthy children using questionnaires. 2) Identify subscales within the questionnaire which needed to be further explored. 3) Use semi-structured interviews with parents of children with low ARM, to explore parenting stress and to explain, expand and or support the quantitative findings. DESIGN AND METHODS: An explanatory sequential mixed methods design was used in this follow up study...
May 17, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29773647/altered-sterol-metabolism-in-budding-yeast-affects-mitochondrial-iron-sulfur-fe-s-cluster-synthesis
#2
Diane M Ward, Opal S Chen, Liangtao Li, Jerry Kaplan, Shah Alam Bhuiyan, Selvamuthu K Natarajan, Martin Bard, James E Cox
Ergosterol synthesis is essential for cellular growth and viability of the budding yeast Saccharomyces cerevisiae, and intracellular sterol distribution and homeostasis are therefore highly regulated in this species. Erg25 is an iron-containing C4-methyl sterol oxidase that contributes to the conversion of 4,4-dimethylzymosterol to zymosterol, a precursor of ergosterol. The ERG29 gene encodes an endoplasmic reticulum (ER)-associated protein, and here we identified a role for Erg29 in the methyl sterol oxidase step of ergosterol synthesis...
May 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29772321/use-of-polidocanol-endovenous-microfoam-to-improve-hemodynamics-and-symptomology-in-patients-with-challenging-clinical-presentations-a-case-series
#3
Paul E Davis, John Phillips, Raghu Kolluri
BACKGROUND: We performed a retrospective review of treatment effects with FDA-approved Polidocanol endovenous microfoam (PEM, Varithena® 1%) on venous symptomology in ten (N=10) C3-C6 patients with chronic venous insufficiency (CVI) and concomitant complex disease/pathology that limited the use of endothermal ablation (ETA). METHODS: Pathology included: risk of bruising or bleeding, severe lipodermatosclerosis (LDS), Hydradenitis Suppurativa, chronic fibrosis of the vein from prior superficial thrombosis, risk for nerve injury and failed prior ETA...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29765910/a-promising-ifn-deficient-system-to-manufacture-ifn-sensitive-influenza-vaccine-virus
#4
Can Chen, Wenhui Fan, Jing Li, Weinan Zheng, Shuang Zhang, Limin Yang, Di Liu, Wenjun Liu, Lei Sun
Interferon (IFN)-sensitive and replication-incompetent influenza viruses are likely to be the alternatives to inactivated and attenuated virus vaccines. Some IFN-sensitive influenza vaccine candidates with modified non-structural protein 1 (NS1) are highly attenuated in IFN-competent hosts but induce robust antiviral immune responses. However, little research has been done on the manufacturability of these IFN-sensitive vaccine viruses. Here, RIG-I-knockout 293T cells were used to package the IFN-sensitive influenza A/WSN/33 (H1N1) virus expressing the mutant NS1 R38A/K41A...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29764917/the-path-to-victory-a-beginner-s-guide-to-success-using-commercial-research-antibodies
#5
REVIEW
Simon L Goodman
Commercial research antibodies are crucial tools in modern cell biology and biochemistry. In the USA some $2 billion a year are spent on them, but many are apparently not fit-for-purpose, and this may contribute to the 'reproducibility crisis' in biological sciences. Inadequate antibody validation and characterization, lack of user awareness, and occasional incompetence amongst suppliers have had immense scientific and personal costs. In this Opinion, I suggest some paths to make the use of these vital tools more successful...
May 15, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29755109/regulated-intratumoral-expression-of-il-12-using-a-rheoswitch-therapeutic-system-%C3%A2-rts-%C3%A2-gene-switch-as-gene-therapy-for-the-treatment-of-glioma
#6
John A Barrett, Hongliang Cai, John Miao, Pranay D Khare, Paul Gonzalez, Jessica Dalsing-Hernandez, Geeta Sharma, Tim Chan, Laurence J N Cooper, Francois Lebel
The purpose of this study was to determine if localized delivery of IL-12 encoded by a replication-incompetent adenoviral vector engineered to express IL-12 via a RheoSwitch Therapeutic System® (RTS® ) gene switch (Ad-RTS-IL-12) administered intratumorally which is inducibly controlled by the oral activator veledimex is an effective approach for glioma therapy. Mice bearing 5-10-day-old intracranial GL-261 gliomas were intratumorally administered Ad-RTS-mIL-12 in which IL-12 protein expression is tightly controlled by the activator ligand, veledimex...
May 14, 2018: Cancer Gene Therapy
https://www.readbyqxmd.com/read/29754390/the-importance-of-contextual-relational-and-cognitive-factors-for-novice-nurses-emotional-state-and-affective-commitment-to-the-profession-a-multilevel-study
#7
Yvonne Ten Hoeve, Jasperina Brouwer, Petrie F Roodbol, Saskia Kunnen
AIM: This study explored the effects of contextual, relational and cognitive factors derived from novice nurses' work experiences on emotions and affective commitment to the profession. BACKGROUND: With an increasing demand for well-trained nurses, it is imperative to investigate which work-related factors most affect their commitment to develop effective strategies to improve work conditions, work satisfaction and emotional attachment. DESIGN: A repeated-measures within subjects design...
May 13, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29753207/an-exploratory-study-of-the-factors-related-to-mouth-breathing-syndrome-in-primary-school-children
#8
Issei Saitoh, Emi Inada, Yasutaka Kaihara, Yukiko Nogami, Daisuke Murakami, Naoko Kubota, Kaoru Sakurai, Yoshito Shirazawa, Tadashi Sawami, Miyuki Goto, Maki Nosou, Katsuyuki Kozai, Haruaki Hayasaki, Youichi Yamasaki
OBJECTIVE: Mouth breathing syndrome (MBS) is defined as a set of signs and symptoms that may be completely or incompletely present in subjects who, for various reasons, replace the correct pattern of nasal breathing with an oral or mixed pattern. It is important to identify the relevant factors affecting MBS in order to diagnose its cause since breathing obstructions can result from multiple factors. The purpose of this study is to clarify the relevant factors and the interrelationships between factors affecting MBS among children...
March 26, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29748576/autophagy-diminishes-the-early-interferon-%C3%AE-response-to-influenza-a-virus-resulting-in-differential-expression-of-interferon-stimulated-genes
#9
Brieuc P Perot, Jeremy Boussier, Nader Yatim, Jeremy S Rossman, Molly A Ingersoll, Matthew L Albert
Influenza A virus (IAV) infection perturbs metabolic pathways such as autophagy, a stress-induced catabolic pathway that crosstalks with cellular inflammatory responses. However, the impact of autophagy perturbation on IAV gene expression or host cell responses remains disputed. Discrepant results may be a reflection of in vivo studies using cell-specific autophagy-related (Atg) gene-deficient mouse strains, which do not delineate modification of developmental programmes from more proximal effects on inflammatory response...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29742538/chronotropic-incompetence-and-reduced-heart-rate-recovery-in-rheumatoid-arthritis
#10
Tiago Peçanha, Reynaldo Rodrigues, Ana Jéssica Pinto, Ana Lúcia Sá-Pinto, Lissiane Guedes, Karina Bonfiglioli, Bruno Gualano, Hamilton Roschel
BACKGROUND/OBJECTIVE: Recent studies have indicated that cardiac autonomic dysfunction is an early sign of cardiovascular impairment in rheumatoid arthritis (RA). Previous studies have mainly focused on resting assessments; however, analysis of heart rate (HR) responses to exercise might provide additional information on cardiac autonomic dysfunction in this disease. Thus, we aimed to assess the HR responses during and after a maximal graded exercise test in patients with RA and healthy controls (CONs)...
May 4, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29741777/developmental-changes-in-longitudinal-associations-between-academic-achievement-and-psychopathological-symptoms-from-late-childhood-to-middle-adolescence
#11
Wenxin Zhang, Liang Zhang, Liang Chen, Linqin Ji, Kirby Deater-Deckard
BACKGROUND: Research reveals longitudinal bidirectional associations between changes in academic achievement and psychopathological symptoms. However, little is known about developmental changes in the magnitude of these associations, from childhood to adolescence. METHODS: Participants were 648 Chinese children (347 males) who were followed from Grade 5 (mean age: 11.18 years) to Grade 9. Academic achievement and two types of symptoms (externalizing, depressive) were assessed annually...
May 9, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29733494/evolutionary-conservation-of-the-allosteric-activation-of-factor-viia-by-tissue-factor-in-lamprey-comment
#12
J J Madsen, E Persson, O H Olsen
We read with great interest the article on allostery in a protease from the blood coagulation cascade by Beeler et al.(1) in a recent issue of Journal of Thrombosis and Haemostasis. Herein, the authors conclude that the allosteric activation of coagulation factor VIIa (FVIIa) by tissue factor (TF) in lamprey (l-) appears indistinguishable from, and conserved compared to, that in human (h-); meaning that l-FVIIa is assumed to be catalytically incompetent unless allosterically activated by l-TF. The lamprey, an ancient jawless eel-like vertebrate, is a fascinating creature and studying its coagulation system can certainly lead to insights into molecular mechanisms of coagulation as well as evolutionary adaptations over hundreds of millions of years (reviewed in (2))...
May 7, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29732502/retention-of-knowledge-and-skills-in-pediatric-basic-life-support-amongst-pediatricians
#13
Mathijs Binkhorst, Michelle Coopmans, Jos M T Draaisma, Petra Bot, Marije Hogeveen
Retention of resuscitation skills is usually assessed at a predefined moment, which enables participants to prepare themselves, possibly introducing bias. In this multicenter study, we evaluated the retention of knowledge and skills in pediatric basic life support (PBLS) amongst 58 pediatricians and pediatric residents with an unannounced examination. Practical PBLS skills were assessed with a validated scoring instrument, theoretical knowledge with a 10-item multiple-choice test (MCQ). Participants self-assessed their PBLS capabilities using five-point Likert scales...
May 7, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29732035/can-chronotropic-incompetence-predict-life-threatening-ventricular-arrhythmias-in-patients-with-stable-ischemic-heart-disease
#14
Yelena Rib, Gulnar Zhussupova, Gaukhar Igimbayeva, Ayan Abdrakhmanov, Seyed Farzad Jalali
Background: Chronotropic incompetence has prognostic value of all-cause and cardiovascular mortality in both patients with asymptomatic and symptomatic ischemic heart disease (IHD), regardless of traditional risk factors. The aim of this study was to investigate the relationship between chronotropic response during exercise test and the development of ventricular arrhythmias. Methods: 153 patients with stable ischemic heart disease were screened and observed during the 24 months since October 2014 in a university hospital in Astana Kazakhstan...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29726605/criminal-responsibility-meta-analysis-and-study-space
#15
Lauren E Kois, Preeti Chauhan
While some correlates of criminal responsibility (CR) outcomes are consistent, others are not. Study-level characteristics, such as sample selection, variability in the operational definition of insanity, or other unknown influences may explain discrepant findings. It is critical to systematically consolidate and assess the literature in order to guide future work. We conducted the first meta-analysis and study space analysis (see Malpass et al., ) in this area. 15 studies met inclusion criteria for the meta-analysis, which encompassed 19,500 cases...
May 4, 2018: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/29725665/venous-pseudoaneurysm-of-the-great-saphenous-vein-stump-as-late-complication-of-flush-saphenofemoral-ligation-and-stripping
#16
Maurizio Domanin, Riccardo Miloro, Silvia Romagnoli, Aldo Basellini
Guidelines now recommend endovenous thermal ablation over open treatment of saphenous incompetence, but flush saphenofemoral ligation and stripping remain relevant when appropriately applied and expertly executed. Complications are rare but could be severe, needing further surgical correction. We report a unique case of a late venous pseudoaneurysm of the great saphenous vein stump after flush saphenofemoral ligation and stripping, successfully treated with surgical sac excision. We highlight the importance of continuous follow-up for patients previously submitted to open venous surgery...
March 2018: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29721351/resolution-of-symptomatic-secondary-empty-sella-syndrome-following-lumbar-peritoneal-shunt
#17
Waseem Mehmood Nizamani, Mubbashira Siddiqui, Sehrish Nizar Ali Momin, Muhammad Waqas, Rashid Jooma
Background: Post-surgical empty sella is related to the removal of pituitary tumors either from the transcranial or transphenoidal route, rendering diaphragma sellae incompetent at the end of the procedure. This subsequently leads to herniation of the third ventricle and optic apparatus into the empty sella. Studies have shown that in 50% of the cases, individuals with primary and secondary empty sella syndrome have developed defects in the visual fields. Benign increased intracranial pressure, cerebrospinal rhinorrhea, papilledema, and abnormalities affecting visual acuity may also occur as a result of empty sella...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29721334/ectopic-fgf-signaling-induces-the-intercalary-response-in-developing-chicken-limb-buds
#18
Aki Makanae, Akira Satoh
Background: Intercalary pattern formation is an important regulatory step in amphibian limb regeneration. Amphibian limb regeneration is composed of multiple steps, including wounding, blastema formation, and intercalary pattern formation. Attempts have been made to transfer insights from regeneration-competent animals to regeneration-incompetent animalsat each step in the regeneration process. In the present study, we focused on the intercalary mechanism in chick limb buds. In amphibian limb regeneration, a proximodistal axis is organized as soon as a regenerating blastema is induced...
2018: Zoological Letters
https://www.readbyqxmd.com/read/29716706/systolic-aortic-regurgitation-in-rheumatic-carditis-mechanistic-insight-by-doppler-echocardiography
#19
Jagdish C Mohan, Vishwas Mohan, Madhu Shukla, Arvind Sethi
BACKGROUND: Aortic regurgitation (AR) usually occurs in diastole in presence of an incompetent aortic valve. Systolic AR is a rare phenomenon occurring in patients with reduced left ventricular systolic pressure and atrial fibrillation or premature ventricular contractions. Its occurrence is a Doppler peculiarity and adds to the hemodynamic burden. AIM: Rheumatic carditis is often characterised by acute or subacute severe mitral regurgitation (MR) due to flail anterior mitral leaflet and elongated chords...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29716613/task-shifting-in-health-service-delivery-from-a-decision-and-policy-makers-perspective-a-case-of-uganda
#20
Sebastian Olikira Baine, Arabat Kasangaki, Euzobia Margaret Mugisha Baine
BACKGROUND: Documented evidence shows that task shifting has been practiced in Uganda to bridge the gaps in the health workers' numbers since 1918. The objectives of this study were to provide a synthesis of the available evidence on task shifting in Uganda; to establish levels of understanding, perceptions on task shifting and acceptability from the decision and policy makers' perspective; and to provide recommendations on the implications of task shifting for the health of the population in Ugandan and human resource management policy...
May 2, 2018: Human Resources for Health
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