Carole Morel, Lyonna F Parise, Yentl Van der Zee, Orna Issler, Min Cai, Caleb Browne, Anthony Blando, Katherine Leclair, Sherod Haynes, Robert W Williams, Megan K Mulligan, Scott J Russo, Eric J Nestler, Ming-Hu Han
Drug addiction is a multifactorial syndrome in which genetic predispositions and exposure to environmental stressors constitute major risk factors for the early onset, escalation, and relapse of addictive behaviors. While it is well known that stress plays a key role in drug addiction, the genetic factors that make certain individuals particularly sensitive to stress and thereby more vulnerable to becoming addicted are unknown. In an effort to test a complex set of gene x environment interactions-specifically gene x chronic stress -here we leveraged a systems genetics resource: BXD recombinant inbred mice (BXD5, BXD8, BXD14, BXD22, BXD29, and BXD32) and their parental mouse lines, C57BL/6J and DBA/2J...
February 28, 2024: bioRxiv