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https://www.readbyqxmd.com/read/29035920/the-antidepressant-like-effects-of-sinomenine-in-mice-a-behavioral-and-neurobiological-characterization
#1
Xiuqin Li, Chao Liu, Bo Jiang, Kai Chen, Wenjuan Li, Hongze Wang
Sinomenine is a bioactive alkaloid extracted from Sinomenium acutum. Here, we investigated the antidepressant effects of sinomenine in mice. The antidepressant actions of sinomenine were first examined in the forced-swim test and the tail-suspension test, and then assessed in the chronic social defeat stress (CSDS) model of depression. Changes in the brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS and sinomenine treatment were also investigated. A tryptophan hydroxylase inhibitor and a BDNF signaling inhibitor were also used to determine the pharmacological mechanisms of sinomenine...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29023276/epidemiology-of-competition-injuries-in-elite-european-judo-athletes-a-prospective-cohort-study
#2
Dušana Čierna, Miloš Štefanovský, Lenka Matejová, Reidar P Lystad
OBJECTIVE: To determine the injury incidence rate (IIR) and injury pattern, and to identify risk factors for injury, among elite adult European judo athletes. DESIGN: Prospective cohort study. SETTING: The 2015 Under 23 European Judo Championships, Bratislava, Slovakia. PARTICIPANTS: All registered athletes (N = 295). INDEPENDENT VARIABLES: Sex, weight division, and fight outcome. MAIN OUTCOME MEASURES: Injury incidence rates were calculated per 1000 athlete-exposures (IIRAE) and per 1000 minutes of exposure (IIRME) with 95% confidence intervals (CI)...
October 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29020387/reversal-of-stress-induced-social-interaction-deficits-by-buprenorphine
#3
Caroline A Browne, Edgardo Falcon, Shivon A Robinson, Olivier Berton, Irwin Lucki
Background: Patients with post-traumatic stress disorder (PTSD) frequently report persistent problems with social interactions, emerging after a traumatic experience. Chronic social defeat stress (CSDS) is a widely used rodent model of stress that produces robust and sustained social avoidance behavior. The avoidance of other rodents can be reversed by 28 days of treatment with selective serotonin reuptake inhibitors (SSRIs), the only pharmaceutical class approved by the U. S. Food and Drug Administration for treating PTSD...
August 31, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29019068/early-epithelial-complications-of-accelerated-trans-epithelial-corneal-crosslinking-in-treatment-of-keratoconus-a-case-series
#4
Sharon S W Chow, Tommy C Y Chan, Ian Y H Wong, Michelle C Y Fan, Jimmy S M Lai, Alex L K Ng
BACKGROUND: To report a case series of early postoperative complications following combined accelerated corneal crosslinking (CXL) and trans-epithelial technique in keratoconus. CASE PRESENTATIONS: Eleven eyes underwent accelerated trans-epithelial CXL (18 mW/cm(2) for 5 min). Seven eyes (64%) developed complications in the first week postoperatively. Five eyes had large epithelial defects, and two eyes were complicated with diffuse punctate epithelial erosions...
October 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29016792/antidepressant-like-actions-of-inhibitors-of-poly-adp-ribose-polymerase-in-rodent-models
#5
Gregory A Ordway, Attila Szebeni, Liza J Hernandez, Jessica D Crawford, Katalin Szebeni, Michelle J Chandley, Katherine C Burgess, Corwin Miller, Erol Bakkalbasi, Russell W Brown
Background: Many patients suffering from depressive disorders are refractory to treatment with currently available antidepressant medications, while many more exhibit only a partial response. These factors drive research to discover new pharmacological approaches to treat depression. Numerous studies demonstrate evidence of inflammation and elevated oxidative stress in major depression. Recently, major depression has been shown to be associated with elevated levels of DNA oxidation in brain cells, accompanied by increased gene expression of the nuclear base excision repair enzyme, poly(ADP-ribose) polymerase-1...
August 3, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28993631/establishment-of-a-repeated-social-defeat-stress-model-in-female-mice
#6
Aki Takahashi, Jia-Ru Chung, Song Zhang, Hongxing Zhang, Yael Grossman, Hossein Aleyasin, Meghan E Flanigan, Madeline L Pfau, Caroline Menard, Dani Dumitriu, Georgia E Hodes, Bruce S McEwen, Eric J Nestler, Ming-Hu Han, Scott J Russo
Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl)...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28986964/escaping-braf-inhibition-a-linc-with-non-coding-rnas
#7
Eleonora Leucci
No abstract text is available yet for this article.
October 6, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28967185/itraq-based-proteomics-suggests-ephb6-as-a-potential-regulator-of-the-erk-pathway-in-the-prefrontal-cortex-of-chronic-social-defeat-stress-model-mice
#8
Hua Guo, Zhi-Lin Huang, Wei Wang, Shu-Xiao Zhang, Juan Li, Ke Cheng, Ke Xu, Yong He, Si-Wen Gui, Peng-Fei Li, Hai-Yang Wang, Zhi-Fang Dong, Peng Xie
PURPOSE: Major depressive disorder (MDD) is a worldwide concern and devastating psychiatric disease. The World Health Organization claims that MDD leads to at least 11.9% of the global burden of disease. However, the underlying pathophysiology mechanisms of MDD remain largely unknown. EXPERIMENTAL DESIGN: Herein, we used a proteomic-based strategy to compare the prefrontal cortex (PFC) in chronic social defeat stress (CSDS) model mice with a control group. Based on pooled samples, differential proteins were identified in the PFC proteome using iTRAQ coupled with LC-MS/MS...
October 1, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28955290/selective-fair-behavior-as-a-function-of-psychopathic-traits-in-a-subclinical-population
#9
Takahiro Osumi, Hideki Ohira
Psychopathy is a group of personality traits that are associated with violations of social norms. Previous studies have suggested that people with psychopathic traits in subclinical populations do not necessarily display antisocial, self-defeating behaviors, and instead may strategically show adaptive behaviors in response to cues during reciprocal social interactions. Therefore, in the present study, we examined whether the association between psychopathic traits and unfair behavior can be moderated by a potential for punishment and social distance (anonymity), which are known to facilitate fair behavior...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28953226/how-canada-changed-from-exporting-asbestos-to-banning-asbestos-the-challenges-that-had-to-be-overcome
#10
Kathleen Ruff
Less than ten years ago, the asbestos industry enjoyed the support of every Quebec and Canadian political party. The Chrysotile Institute and the International Chrysotile Association, both located in Quebec, aggressively marketed asbestos around the world, claiming scientific evidence showed that chrysotile asbestos could be safely used. The industry created a climate of intimidation. Consequently, no groups advocating for victims of asbestos or campaigning for its outright ban existed in Quebec to challenge the industry...
September 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28952484/fixation-release-and-the-bone-bandaid-a-new-bone-fixation-device-paradigm
#11
Narges Shayesteh Moghaddam, Ahmadreza Jahadakbar, Amirhesam Amerinatanzi, Roman Skoracki, Michael Miller, David Dean, Mohammad Elahinia
The current gold standard of care for mandibular segmental defeat reconstruction is the use of Ti-6Al-4V immobilization hardware and fibular double barrel graft. This method is often successful immediately at restoring mandible function, however the highly stiff fixation hardware causes stress shielding of the grafted bone and stress concentration in the fixation device over time which can lead to fixation device failure and revision surgery. The purpose of reconstructive surgery could be to create normal stress trajectories in the mandible following engraftment...
January 22, 2017: Bioengineering
https://www.readbyqxmd.com/read/28949742/kolmogorov-turbulence-defeated-by-anderson-localization-for-a-bose-einstein-condensate-in-a-sinai-oscillator-trap
#12
Leonardo Ermann, Eduardo Vergini, Dima L Shepelyansky
We study the dynamics of a Bose-Einstein condensate in a Sinai-oscillator trap under a monochromatic driving force. Such a trap is formed by a harmonic potential and a repulsive disk located in the center vicinity corresponding to the first experiments of condensate formation by Ketterle and co-workers in 1995. We allow that the external driving allows us to model the regime of weak wave turbulence with the Kolmogorov energy flow from low to high energies. We show that in a certain regime of weak driving and weak nonlinearity such a turbulent energy flow is defeated by the Anderson localization that leads to localization of energy on low energy modes...
August 4, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28942119/21st-century-neurobehavioral-theories-of-decision-making-in-addiction-review-and-evaluation
#13
REVIEW
Warren K Bickel, Alexandra M Mellis, Sarah E Snider, Liqa N Athamneh, Jeffrey S Stein, Derek A Pope
This review critically examines neurobehavioral theoretical developments in decision making in addiction in the 21st century. We specifically compare each theory reviewed to seven benchmarks of theoretical robustness, based on their ability to address: why some commodities are addictive; developmental trends in addiction; addiction-related anhedonia; self-defeating patterns of behavior in addiction; why addiction co-occurs with other unhealthy behaviors; and, finally, means for the repair of addiction. We have included only self-contained theories or hypotheses which have been developed or extended in the 21st century to address decision making in addiction...
September 20, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28938860/pharmacophore-generation-atom-based-3d-qsar-molecular-docking-and-molecular-dynamics-simulation-studies-on-benzamide-analogues-as-ftsz-inhibitors
#14
Swayansiddha Tripathy, Mohammed Afzal Azam, Srikanth Jupudi, Susanta Kumar Sahu
FtsZ is an appealing target for the design of antimicrobial agent that can be used to defeat the multidrug-resistant bacterial pathogens. Pharmacophore modelling, molecular docking and molecular dynamics (MD) simulation studies were performed on a series of three-substituted benzamide derivatives. In the present study a five-featured pharmacophore model with one hydrogen bond acceptors, one hydrogen bond donors, one hydrophobic and two aromatic rings was developed using 97 molecules having MIC values ranging from ...
October 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28935447/prosocial-effects-of-prolactin-in-male-rats-social-recognition-social-approach-and-social-learning
#15
Mary E Donhoffner, Samar Al Saleh, Olivia Schink, Ruth I Wood
Prolactin (PRL) and oxytocin (OT) are pituitary hormones essential for lactation, but also promote sexual behavior. OT stimulates social behaviors, such as recognition, approach, and learning, but less is known about PRL in these behaviors. Since PRL and OT have complementary functions in reproduction, we hypothesized that PRL increases social recognition, approach, and learning. Male Long-Evans rats received ovine PRL (oPRL; 0.5, 2.0 or 5.0mg/kg), the PRL antagonist bromocriptine (0.1, 3.0 or 5.0mg/kg) or saline 20 mins before testing for recognition of familiar vs...
September 24, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28924188/dopamine-d1-receptor-subtype-mediates-acute-stress-induced-dendritic-growth-in-excitatory-neurons-of-the-medial-prefrontal-cortex-and-contributes-to-suppression-of-stress-susceptibility-in-mice
#16
R Shinohara, M Taniguchi, A T Ehrlich, K Yokogawa, Y Deguchi, Y Cherasse, M Lazarus, Y Urade, A Ogawa, S Kitaoka, A Sawa, S Narumiya, T Furuyashiki
Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the dysfunction of prefrontal dopamine has been associated with cognitive and emotional deficits in mental illnesses. These findings have led to clinical trials of dopamine-targeting drugs and brain imaging of dopamine receptors in patients with mental illnesses. Rodent studies have suggested that dopaminergic pathway projecting to the medial prefrontal cortex (mPFC) suppresses stress susceptibility. Although various types of mPFC neurons express several dopamine receptor subtypes, previous studies neither isolated a role of dopamine receptor subtype nor identified the site of its action in mPFC...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28915381/adult-vitamin-d-deficiency-exacerbates-impairments-caused-by-social-stress-in-balb-c-and-c57bl-6-mice
#17
Natalie J Groves, Mei Zhou, Dhanisha J Jhaveri, John J McGrath, Thomas H J Burne
Vitamin D deficiency is prevalent in adults throughout the world. Epidemiological studies have shown significant associations between vitamin D deficiency and an increased risk of various neuropsychiatric and neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease and cognitive impairment. However, studies based on observational epidemiology cannot address questions of causality; they cannot determine if vitamin D deficiency is a causal factor leading to the adverse health outcome...
September 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28911877/validity-and-reliability-of-naturalistic-driving-scene-categorization-judgments-from-crowdsourcing
#18
Christopher D D Cabrall, Zhenji Lu, Miltos Kyriakidis, Laura Manca, Chris Dijksterhuis, Riender Happee, Joost de Winter
A common challenge with processing naturalistic driving data is that humans may need to categorize great volumes of recorded visual information. By means of the online platform CrowdFlower, we investigated the potential of crowdsourcing to categorize driving scene features (i.e., presence of other road users, straight road segments, etc.) at greater scale than a single person or a small team of researchers would be capable of. In total, 200 workers from 46 different countries participated in 1.5days. Validity and reliability were examined, both with and without embedding researcher generated control questions via the CrowdFlower mechanism known as Gold Test Questions (GTQs)...
September 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28910319/chronic-social-defeat-induces-long-term-behavioral-depression-of-aggressive-motivation-in-an-invertebrate-model-system
#19
Jacqueline Rose, Jan Rillich, Paul A Stevenson
Losing a fight against a conspecific male (social defeat) induces a period of suppressed aggressiveness and general behaviour, often with symptoms common to human psychiatric disorders. Agonistic experience is also discussed as a potential cause of consistent, behavioral differences between individuals (animal "personality"). In non-mammals, however, the impact of single agonistic encounters typically last only hours, but then again studies of repeated intermittent defeat (chronic social defeat) are seldom...
2017: PloS One
https://www.readbyqxmd.com/read/28903671/humor-use-moderates-the-relation-of-stressful-life-events-with-psychological-distress
#20
Heidi L Fritz, Leslie N Russek, Melissa M Dillon
Three studies examined humor and adjustment to stressful events. In Study 1, patients with fibromyalgia syndrome ( N = 22) reported on mental and physical adjustment, social interaction, and reappraisal of their illness. Dispositional humor was associated with reduced distress and fewer physical symptoms. Study 2 ( N = 109) examined undergraduates' reports of stressful events. Dispositional, self-enhancing, affiliative, and self-defeating humor showed direct effects on distress, which were mediated by social interaction and reappraisal...
June 2017: Personality & Social Psychology Bulletin
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