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https://www.readbyqxmd.com/read/28547794/antidepressant-like-effects-of-tetrahydroxystilbene-glucoside-in-mice-involvement-of-bdnf-signaling-cascade-in-the-hippocampus
#1
Hao Wang, Ying Zhao, Ying-Jie Wang, Lu Song, Jin-Liang Wang, Chao Huang, Wei Zhang, Bo Jiang
BACKGROUND AND AIMS: Current antidepressants in clinic need weeks of administration and always have significant limitations. Tetrahydroxystilbene glucoside (TSG) is one of the major bioactive ingredients of Polygonum multiflorum with neuroprotective effects. This study aimed to evaluate the antidepressant effects of TSG in mice. METHODS: The antidepressant-like effects of TSG in mice were examined in the forced swim test (FST), tail suspension test (TST), and chronic social defeat stress (CSDS) model of depression...
May 25, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28540928/anxiety-associated-increased-cpg-methylation-in-the-promoter-of-asb1-a-translational-approach-evidenced-by-epidemiological-and-clinical-studies-and-a-murine-model
#2
Rebecca T Emeny, Jens Baumert, Anthony S Zannas, Sonja Kunze, Simone Wahl, Stella Iurato, Janine Arloth, Angelika Erhardt, Georgia Balsevich, Mathias V Schmidt, Peter Weber, Anja Kretschmer, Liliane Pfeiffer, Johannes Kruse, Konstantin Strauch, Michael Roden, Christian Herder, Wolfgang Koenig, Christian Gieger, Melanie Waldenberger, Annette Peters, Elisabeth B Binder, Karl-Heinz Ladwig
Epigenetic regulation in anxiety is suggested, but evidence from large studies is needed. We conducted an epigenome-wide association study (EWAS) on anxiety in a population-based cohort and validated our finding in a clinical cohort as well as a murine model. In the KORA cohort, participants (n=1522, age 32-72 years) were administered the Generalized Anxiety Disorder (GAD-7) instrument, whole blood DNA methylation was measured (Illumina 450 K BeadChip) and circulating levels of hs-CRP and IL-18 were assessed in the association between anxiety and methylation...
May 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28537235/-serotonergic-genes-in-the-development-of-anxiety-depression-like-state-and-pathology-of-aggressive-behavior-in-male-mice-rna-seq-data
#3
N N Kudryavtseva, D A Smagin, I L Kovalenko, A G Galyamina, G B Vishnivetskaya, V N Babenko, Yu L Orlov
In course of daily agonistic interactions, mice tend to stratify into those with chronic social defeats and those that repeatedly display aggression, which lead to the development of mixed anxiety/depression-like state and the pathology of aggressive behavior, respectively. Using the data of whole transcriptome analysis (RNA-seq), the changes in the expression of serotonergic genes involved in the synthesis, inactivation, and reception of serotonin, as well as of the Creb1 (transcription factor) gene and the Bdnf (brain-derived neurotrophic factor) gene were detected in the striatum (STR), ventral tegmental area (VTA), midbrain raphe nuclei (MRN), hypothalamus (HYP), and hippocampus (HIP) of defeated and aggressive male mice...
March 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28536503/epigenetic-activation-of-asct2-in-the-hippocampus-contributes-to-depression-like-behavior-by-regulating-d-serine-in-mice
#4
Jiesi Wang, Ke Zhang, Xiaojuan Chen, Xiaoqian Liu, Huajing Teng, Mei Zhao, Zhongsheng Sun
The roles of D-serine in depression are raised concerned recently as an intrinsic co-agonist for the NMDA receptor. However, the mechanisms underlying its regulation are not fully elucidated. ASCT2 is a Na(+)-dependent D-serine transporter. We found that decreased D-serine and increased hippocampal ASCT2 levels correlated with chronic social defeat stress (CSDS) in mice. Lentivirus-mediated shRNA-mediated knockdown of ASCT2 and the administration of exogenous D-serine in the hippocampus alleviated CSDS-induced social avoidance and immobility...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28536351/oncolytic-vesicular-stomatitis-virus-as-a-viro-immunotherapy-defeating-cancer-with-a-hammer-and-anvil
#5
REVIEW
Michael Karl Melzer, Arturo Lopez-Martinez, Jennifer Altomonte
Oncolytic viruses have gained much attention in recent years, due, not only to their ability to selectively replicate in and lyse tumor cells, but to their potential to stimulate antitumor immune responses directed against the tumor. Vesicular stomatitis virus (VSV), a negative-strand RNA virus, is under intense development as an oncolytic virus due to a variety of favorable properties, including its rapid replication kinetics, inherent tumor specificity, and its potential to elicit a broad range of immunomodulatory responses to break immune tolerance in the tumor microenvironment...
February 10, 2017: Biomedicines
https://www.readbyqxmd.com/read/28511867/social-housing-and-social-isolation-impact-on-stress-indices-and-energy-balance-in-male-and-female-syrian-hamsters-mesocricetus-auratus
#6
Amy P Ross, Alisa Norvelle, Dennis C Choi, James C Walton, H Elliott Albers, Kim L Huhman
Although Syrian hamsters are thought to be naturally solitary, recent evidence from our laboratory demonstrates that hamsters may actually prefer social contact. Hamsters increase their preference for a location associated with an agonistic encounter regardless of whether they have "won" or "lost". It has also been reported that social housing as well as exposure to intermittent social defeat or to a brief footshock stressor increase food intake and body mass in hamsters. By contrast, it has also been suggested that housing hamsters in social isolation causes anxiety-induced anorexia and reductions in body mass selectively in females...
May 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28500512/molecular-adaptations-to-social-defeat-stress-and-induced-depression-in-mice
#7
Natalya Bondar, Leonid Bryzgalov, Nikita Ershov, Fedor Gusev, Vasiliy Reshetnikov, Damira Avgustinovich, Mikhail Tenditnik, Evgeny Rogaev, Tatiana Merkulova
Chronic stress is a risk factor for major depression. Social defeat stress is a well-validated murine model of depression. However, little is known about the gene activity dynamics during the development of a depression-like state. We analyzed the effects of social defeat stress of varying duration (10 and 30 days) on the behavioral patterns and prefrontal-cortex transcriptome of C57BL/6 mice. The 10-day exposure to social defeat stress resulted in a high level of social avoidance with no signs of depression-associated behavior...
May 12, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28499631/extrafibrillar-collagen-demineralization-based-chelate-and-rinse-technique-bridges-the-gap-between-wet-and-dry-dentin-bonding
#8
Sui Mai, Chin-Chuan Wei, Li-Sha Gu, Fu-Cong Tian, Dwayne D Arola, Ji-Hua Chen, Yang Jiao, David H Pashley, Li-Na Niu, Franklin R Tay
Limitations associated with wet-bonding led to the recent development of a selective demineralization strategy in which dentin was etched with a reduced concentration of phosphoric acid to create exclusive extrafibrillar demineralization of the collagen matrix. However, the use of acidic conditioners removes calcium via diffusion of very small hydronium ions into the intrafibrillar collagen water compartments. This defeats the purpose of limiting the conditioner to the extrafibrillar space to create a collagen matrix containing only intrafibrillar minerals to prevent collapse of the collagen matrix...
May 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28495706/in-a-first-natural-selection-defeats-a-biocontrol-insect
#9
Elizabeth Pennisi
No abstract text is available yet for this article.
May 12, 2017: Science
https://www.readbyqxmd.com/read/28493335/response-of-htr3a-ko-mice-to-antidepressant-treatment-and-chronic-stress
#10
Vincent Martin, Armance Riffaud, Tevrasamy Marday, Charly Brouillard, Bernard Franc, Jean-Pol Tassin, Caroline Sevoz-Couche, Raymond Mongeau, Laurence Lanfumey
BACKGROUND AND PURPOSE: It has recently been suggested that 5-HT3 receptor blockade enhances selective serotonin reuptake inhibitor (SSRI) antidepressants efficacy and may reverse stress-induced deficits in rodents. EXPERIMENTAL APPROACH: To further explore this hypothesis, we used mice lacking the 5-HT3 receptor (Htr3a KO) and their wild-type (WT) controls to assess their response in behavioural paradigms relevant to anxiety and depression. Mice were studied under basal, antidepressant treatments and chronic social defeat stress (CSDS) conditions...
May 10, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28489969/barriers-towards-help-seeking-among-young-men-prior-to-suicide
#11
Mette Lyberg Rasmussen, Heidi Hjelmeland, Gudrun Dieserud
This study explores barriers to help-seeking among young men prior to suicide. We analysed 61in -depth interviews with parents, siblings, friends, and ex-partners of ten young men (aged 18-30) with no record of mental illness, as well as six suicide notes, using Interpretative Phenomenological Analysis. Three barriers emerged: (a) A total defeat; (b) No room for weakness; and (c) Fear of mental disorder. The shame from falling short of standards (own/significant male others') could be a considerable barrier to help-seeking in a suicidal crisis...
May 10, 2017: Death Studies
https://www.readbyqxmd.com/read/28473794/experimentally-manipulating-items-informs-on-the-limited-construct-and-criterion-validity-of-the-humor-styles-questionnaire
#12
Willibald Ruch, Sonja Heintz
How strongly does humor (i.e., the construct-relevant content) in the Humor Styles Questionnaire (HSQ; Martin et al., 2003) determine the responses to this measure (i.e., construct validity)? Also, how much does humor influence the relationships of the four HSQ scales, namely affiliative, self-enhancing, aggressive, and self-defeating, with personality traits and subjective well-being (i.e., criterion validity)? The present paper answers these two questions by experimentally manipulating the 32 items of the HSQ to only (or mostly) contain humor (i...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28468880/selective-activation-of-interferon-%C3%AE-signaling-by-zika-virus-ns5-protein
#13
Vidyanath Chaudhary, Kit-San Yuen, Jasper Fuk-Woo Chan, Ching-Ping Chan, Pei-Hui Wang, Jian-Piao Cai, Shuo Zhang, Mifang Liang, Kin-Hang Kok, Chi-Ping Chan, Kwok-Yung Yuen, Dong-Yan Jin
Severe complications of Zika virus (ZIKV) infection might be caused by inflammation. How ZIKV induces pro-inflammatory cytokines is not understood. In this study, we show opposite regulatory effect of ZIKV NS5 protein on interferon (IFN) signaling. Whereas ZIKV and its NS5 protein were potent suppressors of type I and type III IFN signaling, they were found to activate IFN-γ signaling. Inversely, IFN-γ augmented ZIKV replication. NS5 interacted with STAT2 and targeted it for ubiquitination and degradation, but had no influence on STAT1 stability or nuclear translocation...
May 3, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28468634/kososan-a-kampo-medicine-prevents-a-social-avoidance-behavior-and-attenuates-neuroinflammation-in-socially-defeated-mice
#14
Naoki Ito, Eiji Hirose, Tatsuya Ishida, Atsushi Hori, Takayuki Nagai, Yoshinori Kobayashi, Hiroaki Kiyohara, Tetsuro Oikawa, Toshihiko Hanawa, Hiroshi Odaguchi
BACKGROUND: Kososan, a Kampo (traditional Japanese herbal) medicine, has been used for the therapy of depressive mood in humans. However, evidence for the antidepressant efficacy of kososan and potential mechanisms are lacking. Recently, it has been recognized that stress triggers neuroinflammation and suppresses adult neurogenesis, leading to depression and anxiety. Here, we examined whether kososan extract affected social behavior in mice exposed to chronic social defeat stress (CSDS), an animal model of prolonged psychosocial stress, and neuroinflammation induced by CSDS...
May 3, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28466092/repeated-social-defeat-and-the-rewarding-effects-of-cocaine-in-adult-and-adolescent-mice-dopamine-transcription-factors-probdnf-signaling-pathways-and-the-trkb-receptor-in-the-mesolimbic-system
#15
Sandra Montagud-Romero, Cristina Nuñez, M Carmen Blanco-Gandia, Elena Martínez-Laorden, María A Aguilar, Javier Navarro-Zaragoza, Pilar Almela, Maria-Victoria Milanés, María-Luisa Laorden, José Miñarro, Marta Rodríguez-Arias
RATIONALE: Repeated social defeat (RSD) increases the rewarding effects of cocaine in adolescent and adult rodents. OBJECTIVE: The aim of the present study was to compare the long-term effects of RSD on the conditioned rewarding effects of cocaine and levels of the transcription factors Pitx3 and Nurr1 in the ventral tegmental area (VTA), the dopamine transporter (DAT), the D2 dopamine receptor (D2DR) and precursor of brain-derived neurotrophic factor (proBDNF) signaling pathways, and the tropomyosin-related kinase B (TrkB) receptor in the nucleus accumbens (NAc) in adult and adolescent mice...
May 2, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28465530/defeating-bacterial-resistance-and-preventing-mammalian-cells-toxicity-through-rational-design-of-antibiotic-functionalized-nanoparticles
#16
Jessica Fernanda Affonso de Oliveira, Ângela Saito, Ariadne Tuckmantel Bido, Jörg Kobarg, Hubert Karl Stassen, Mateus Borba Cardoso
The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biological responses. The obtained silver nanoparticles coated with mesoporous silica functionalized with ampicillin presented remarkable antimicrobial effects against susceptible and antibiotic-resistant Escherichia coli...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28462942/cell-type-specific-epigenetic-editing-at-the-fosb-gene-controls-susceptibility-to-social-defeat-stress
#17
Peter J Hamilton, Dominika J Burek, Sonia I Lombroso, Rachael L Neve, Alfred J Robison, Eric J Nestler, Elizabeth A Heller
Chronic social defeat stress regulates the expression of Fosb in the nucleus accumbens (NAc) to promote the cell-type specific accumulation of ΔFosB in the two medium spiny neuron (MSN) subtypes in this region. ΔFosB is selectively induced in D1-MSNs in the NAc of resilient mice, and in D2-MSNs of susceptible mice. However, little is known about the consequences of such selective induction, particularly in D2-MSNs. This study examined how cell-type specific control of the endogenous Fosb gene in NAc regulates susceptibility to social defeat stress...
May 2, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28458154/sauroxine-reduces-memory-retention-in-rats-and-impairs-hippocampal-long-term-potentiation-generation
#18
Mariana Vallejo, Valeria Carlini, Laura Gabach, M G Ortega, José L Cabrera, Susana Rubiales de Barioglio, Mariela Pérez, Alicia M Agnese
In the present paper it was investigated the role of sauroxine, an alkaloid of Phlegmariurus saururus, as a modulator of some types of learning and memory, considering the potential nootropic properties previously reported for the alkaloid extract and the main alkaloid sauroine. Sauroxine was isolated by means of an alkaline extraction, purified by several chromatographic techniques, and assayed in electrophysiological experiments on rat hippocampus slices, tending towards the elicitation of the long-term potentiation (LTP) phenomena...
April 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28453574/social-defeat-stress-causes-depression-like-behavior-with-metabolite-changes-in-the-prefrontal-cortex-of-rats
#19
Yi-Yun Liu, Xin-Yu Zhou, Li-Ning Yang, Hai-Yang Wang, Yu-Qing Zhang, Jun-Cai Pu, Lan-Xiang Liu, Si-Wen Gui, Li Zeng, Jian-Jun Chen, Chan-Juan Zhou, Peng Xie
Major depressive disorder is a serious mental disorder with high morbidity and mortality. The role of social stress in the development of depression remains unclear. Here, we used the social defeat stress paradigm to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography-mass spectrometry. Within the first week after the social defeat procedure, the sucrose preference test (SPT), open field test (OFT), elevated plus maze (EPM) and forced swim test (FST) were conducted to examine the depressive-like and anxiety-like behaviors...
2017: PloS One
https://www.readbyqxmd.com/read/28450840/more-than-the-win-the-relation-between-appetitive-competition-motivation-socialization-and-gender-role-orientation-in-women-s-football
#20
Danie Meyer-Parlapanis, Sabrina Siefert, Roland Weierstall
The ability to produce peak performance plays a decisive role in the success of athletes in competitive contest situations. Levels of appetitive competition motivation (ACM), i.e., the desire to defeat an opponent independent of secondary reinforcing factors, were assessed in professional female football/soccer players in the premier and regional leagues, using club level as the measurement of sport success. Furthermore, the influence of social environments predominantly encouraging masculine and competitive play behavior and the players' perceptions of their own gender role orientations were investigated...
2017: Frontiers in Psychology
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