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https://www.readbyqxmd.com/read/29475192/infants-understanding-of-the-definite-indefinite-article-in-a-third-party-communicative-situation
#1
You-Jung Choi, Hyun-Joo Song, Yuyan Luo
The present study examines how infants use their emergent perspective-taking and language comprehension abilities to make sense of interactions between two human agents. In the study, one agent (Agent1) could see only one of two identical balls on an apparatus because of a screen obstructing her view while the infant and another agent (Agent2) could see both balls. 19-month-old English-learning monolingual infants seemed to expect Agent2 to grasp the ball visible to Agent1 when she said to Agent2 "Give me the ball" but not when she said "Give me a ball...
February 20, 2018: Cognition
https://www.readbyqxmd.com/read/29475156/potent-hydrazone-derivatives-targeting-esophageal-cancer-cells
#2
Ling-Yu Li, Jia-Di Peng, Wenjuan Zhou, Hui Qiao, Xin Deng, Zhou-Hua Li, Ji-Deng Li, Yun-Dong Fu, Song Li, Kai Sun, Hong-Min Liu, Wen Zhao
Hydrazone and their derivatives are a series of highly active molecules, which are widely used as lead compounds for the research and development of new anti-cancer drugs. In this study, 20 compounds were synthesized, based on this scaffold and their in vitro cytotoxicity against 6 cancer cell lines, including EC9706, SMMC-7721, MCF7, PC3, MGC-803 and EC109 was tested. Among them, compound 6p, showed strong anti-proliferative activities on esophageal carcinoma cells: EC9706 and EC109 with IC50 values of 1...
February 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29475141/quercetin-enhances-chemotherapeutic-effect-of-doxorubicin-against-human-breast-cancer-cells-while-reducing-toxic-side-effects-of-it
#3
Shizheng Li, Song Yuan, Qian Zhao, Bo Wang, Xiuyan Wang, Kun Li
Doxorubicin (Dox) is an efficient drug for breast cancer chemotherapy, however, its toxic side effects on non-tumor tissues, especially on myocardial cells, sometimes limit its clinical application. Therefore, it is necessary to develop a new drug, which can be combined with Dox to potentiate the anti-tumor effect of Dox at a lower concentration and attenuate the toxic side effects of it. Quercetin (Que) has anti-tumor activity in addition to its protective effects on various cells. By preparing human non-tumoral MCF-10A mammary cells, human breast cancer MCF-7 and MDA-MB-231 cells and human myocardial AC16 cells, here, we wanted to evaluate whether Que might represent such an agent and investigate its possible mechanisms of potentiating the anti-tumor effect of Dox at a lower concentration...
February 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29475083/seasonal-dynamics-in-the-community-structure-and-trophic-structure-of-testate-amoebae-inhabiting-the-sanjiang-peatlands-northeast-china
#4
Lihong Song, Hongkai Li, Kehong Wang, Xiumin Yan, Donghui Wu
Peatlands cover 3% of the earth's land surface but contain 30% of the world's soil carbon pool. Microbial communities constitute a crucial detrital food web for nutrient and carbon cycling in peatlands. Heterotrophic protozoans are considered top predators in the microbial food web; however, they are not yet well understood. In this study, we investigated seasonal dynamics in the community and the trophic structure of testate amoebae in four peatlands. Testate amoebae density and biomass in August were significantly higher than those in May and October...
February 6, 2018: European Journal of Protistology
https://www.readbyqxmd.com/read/29475068/acute-subchronic-oral-toxicity-toxicokinetics-and-genotoxicity-studies-of-dfc-2-an-antitubercular-drug-candidate
#5
Hoonhee Seo, Hafij Al Mahmud, Sukyung Kim, Md Imtiazul Islam, Kee-In Lee, Young Sig Gil, Ho-Yeon Song
The infectious disease tuberculosis remains a serious global health issue and is responsible for nearly 1.8 million deaths every year. In our previous study, DFC-2 was confirmed to show anti-tubercular activity against drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis. To support the safety-in-use of DFC-2 as an anti-tubercular drug, DFC-2 was tested via single- and 28-day repeated-dose oral toxicity study and mutagenicity assays. In the oral toxicity study, a single oral dose of DFC-2 at 2000 mg/kg did not produce deaths or abnormal lesions in the internal organs of rats...
February 20, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29474977/activated-production-of-silent-metabolites-from-marine-derived-fungus-penicillium-citrinum
#6
Yuqin Gu, Peiyu Ding, Zhipeng Liang, Yan Song, Yonghong Liu, Guangtong Chen, Jian Lin Li
As an attempt to utilize of rare earth elements as a novel method to activate the silent genes in fungus, the marine-derived fungus Penicillium citrinum was cultured under ordinary laboratory fermentation conditions in the presence of scandium chloride (ScCl3 , 50 μM), and chemical investigation led to the isolation and characterization of three new peptide derivatives (1-3), along with four known pyrrolidine alkaloids (4-7). Those structures were elucidated by spectroscopic data interpretation, as well as chemical reactions...
February 20, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29474879/quantitative-analysis-of-relative-volume-of-low-apparent-diffusion-coefficient-value-can-predict-neurologic-outcome-after-cardiac-arrest
#7
Hyung Ki Moon, Jinhee Jang, Kyu Nam Park, Soo Hyun Kim, Byung Kook Lee, Sang Hoon Oh, Kyung Woon Jeung, Seung Pill Choi, In Soo Cho, Chun Song Youn
INTRODUCTION: Predicting neurologic outcomes after cardiac arrest (CA) is challenging. This study tested the hypothesis that a quantitative analysis of diffusion weighted imaging (DWI) using the FMRIB Software Library (FSL) can predict neurologic outcomes after CA and can clarify the optimal apparent diffusion coefficient (ADC) thresholds for predicting poor neurologic outcomes. METHODS: Out-of-hospital CA patients treated with targeted temperature management (TTM) who underwent DWI were included in this study...
February 20, 2018: Resuscitation
https://www.readbyqxmd.com/read/29474870/improving-revised-international-prognostic-scoring-system-ipss-r-pre-allogeneic-stem-cell-transplant-does-not-translate-into-better-post-transplant-outcomes-for-patients-with-myelodysplastic-syndromes-a-single-center-experience
#8
Musa Alzahrani, Maryse Power, Yasser Abou Mourad, Michael Barnett, Raewyn Broady, Donna Forrest, Alina Gerrie, Donna Hogge, Stephen Nantel, David Sanford, Kevin Song, Heather Sutherland, Cynthia Toze, Thomas Nevill, Sujaatha Narayanan
BACKGROUND: The natural history of patients with myelodysplastic syndromes (MDS) is variable. The revised international prognostic score (IPSS-R) is commonly used in practice to predict outcome in patients with MDS both at diagnosis and pre-transplant. However the effect of change in IPSS-R pre-allogeneic stem cell transplant with chemotherapy or hypomethylating agents on post-transplant outcomes is currently unknown. AIM: We assessed if improvement in IPSS-R prognostic score pre HSCT would result in improvement in clinical outcomes post-transplant...
February 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29474854/evidence-for-a-neural-signature-of-musical-preference-during-silence
#9
Joucla Coralie, Nicolier Magali, Giustiniani Julie, Brunotte Gaelle, Noiret Nicolas, Monnin Julie, Magnin Eloi, Pazart Lionel, Moulin Thierry, Haffen Emmanuel, Vandel Pierre, Gabriel Damien
One of the most basic and person-specific affective responses to music is liking. The present investigation sought to determine whether liking was preserved during spontaneous auditory imagery. To this purpose, we inserted two-second silent intervals into liked and disliked songs, a method known to automatically recreate a mental image of these songs. Neural correlates of musical preference were measured by high-density electroencephalography in twenty subjects who had to listen to a set of five pre-selected unknown songs the same number of times for two weeks...
February 20, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29474848/urology-consultation-and-emergency-department-revisits-for-children-with-urinary-stone-disease
#10
Jane Kurtzman, Lihai Song, Michelle E Ross, Charles D Scales, David I Chu, Gregory E Tasian
PURPOSE: To determine the association between urology consultation and emergency department (ED) revisits for children with urinary stones. MATERIALS AND METHODS: This retrospective cohort study included patients ≤18 years-old who presented to an ED in South Carolina with a urinary stone from 1997-2015. The primary exposure was urology consultation during the index ED visit. The primary outcome was a stone-related ED revisit occurring within 180 days of discharge from an index ED visit...
February 20, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29474710/carbohydrate-dynamics-of-three-dominant-species-in-a-chinese-savanna-under-precipitation-exclusion
#11
Yanqiang Jin, Jing Li, Chenggang Liu, Yuntong Liu, Yiping Zhang, Liqing Sha, Zhe Wang, Qinghai Song, Youxing Lin, Ruiwu Zhou, Aiguo Chen, Peiguang Li, Xuehai Fei, John Grace
The potential impact of drought on the carbon balance in plants has gained great attention. Non-structural carbohydrate (NSC) dynamics have been suggested as an important trait reflecting carbon balance under drought conditions. However, NSC dynamics under drought and the response mechanisms of NSC to drought remain unclear, especially in water-limited savanna ecosystems. A precipitation exclusion experiment was performed to simulate different drought intensities in a savanna ecosystem in Yuanjiang valley in southwestern China...
February 21, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29474693/the-use-of-rna-sequencing-and-correlation-network-analysis-to-study-potential-regulators-of-leaf-color-transformation
#12
Tuo Yang, Keting Li, Suxiao Hao, Jie Zhang, Tingting Song, Ji Tian, Yuncong Yao
Anthocyanins are plant pigments that contribute to the color of leaves, flowers and fruits, and that beneficial to human health in the form of dietary antioxidants. The study of a transformable crabapple cultivar, 'India magic', which has red buds and green mature leaves, using mRNA profiling of four leaf developmental stages, allowed us to characterize molecular mechanisms regulating red color formation in early leaf development and the subsequent rapid down-regulation of anthocyanin biosynthesis. This analysis of differential gene expression during leaf development, revealed that ethylene signaling responsive genes are upregulated during leaf pigmentation...
February 20, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29474489/insect-tissue-specific-vitellogenin-facilitates-transmission-of-plant-virus
#13
Yan Huo, Yuanling Yu, Liying Chen, Qiong Li, Mengting Zhang, Zhiyu Song, Xiaoying Chen, Rongxiang Fang, Lili Zhang
Insect vitellogenin (Vg) has been considered to be synthesized in the fat body. Here, we found that abundant Vg protein is synthesized in Laodelphax striatellus hemocytes as well. We also determined that only the hemocyte-produced Vg binds to Rice stripe virus (RSV) in vivo. Examination of the subunit composition of L. striatellus Vg (LsVg) revealed that LsVg was processed differently after its expression in different tissues. The LsVg subunit able to bind to RSV exist stably only in hemocytes, while fat body-produced LsVg lacks the RSV-interacting subunit...
February 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29474312/benchmarking-implications-analysis-of-medicare-accountable-care-organizations-spending-level-and-quality-of-care
#14
Young-Rock Hong, Frederick Kates, Soon Ju Song, Nayoung Lee, R Paul Duncan, Nicole M Marlow
Early evidence has shown that Accountable Care Organizations (ACOs) have achieved some success in improving the quality of care and reducing Medicare costs. However, it has been argued that the ACO rewarding model may disproportionately affect relatively low-spending (LS; considered as efficient) organizations that have fewer options to cut unnecessary services compared with high-spending (HS; inefficient) organizations. We conducted a cross-sectional retrospective study to compare ACO financial and quality of care performance between HS-ACO and LS-ACO...
February 16, 2018: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/29474123/neuroprotective-effects-of-the-methanol-extract-of-kimchi-a-korean-fermented-vegetable-food-mediated-via-suppression-of-endoplasmic-reticulum-stress-and-caspase-cascade-pathways-in-high-cholesterol-diet-fed-mice
#15
Serim Kim, Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
Endoplasmic reticulum (ER) stress-related unfolded peptide accumulation is closely associated with the development of neurodegenerative diseases known as protein misfolding disorders. The antioxidative properties of kimchi, a traditional Korean fermented vegetable dish, have been well established. In this study, the neuroprotective effects of the kimchi methanol extract (KME) were examined in high-cholesterol diet (HCD)-fed mice. The animals were fed a HCD, with oral administration of either KME (KME group, 200 mg·kg bw-1 ·day-1 , n = 10) or distilled water (Control group, n = 10) for 8 weeks...
February 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29474103/hypolipidemic-and-antidiabetic-effects-of-functional-rice-cookies-in-high-fat-diet-fed-icr-mice-and-db-db-mice
#16
Sun Hee Hong, Minji Woo, Mijeong Kim, Yeong Ok Song
We have previously reported the lipid-lowering effects of a Korean rice cookie called dasik (RCD) in comparison with a western style cookie. In this study, Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) fruit-supplemented RCD (SRCD) was added to a diet, and the hypolipidemic and antidiabetic effects of different diets were examined by using the ICR and db/db mouse models, respectively. ICR mice were fed the AIN-76 diet, or high-fat diet (HFD), or the RCD- or SRCD-supplemented HFD (10%, w/w) for 9 weeks (n = 7 per group)...
February 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29474001/proteogenomic-analysis-to-identify-missing-proteins-from-haploid-cell-lines
#17
Seung-Eun Lee, JongKeon Song, Korbinian Bösl, André C Müller, Dijana Vitko, Keiryn L Bennett, Giulio Superti-Furga, Akhilesh Pandey, Richard K Kandasamy, Min-Sik Kim
Chromosome-centric Human Proteome Project aims at identifying and characterizing protein products encoded from all human protein-coding genes. As of early 2017, 19,837 protein-coding genes have been annotated in the neXtProt database including 2,691 missing proteins that have never been identified by mass spectrometry. Missing proteins may be low abundant in many cell types or expressed only in a few cell types in human body such as sperms in testis. In this study, we performed expression proteomics of two near haploid cell types such as HAP1 and KBM-7 to hunt for missing proteins...
February 23, 2018: Proteomics
https://www.readbyqxmd.com/read/29473979/a-novel-glp-1-gip-gcg-triagonist-reduces-cognitive-deficits-and-pathology-in-the-3xtg-mouse-model-of-alzheimer-s-disease
#18
Tian Li, Juan-Juan Jiao, Christian Hölscher, Mei-Na Wu, Jun Zhang, Jia-Qing Tong, Xue-Fan Dong, Xue-Song Qu, Yue Cao, Hong-Yan Cai, Qiang Su, Jin-Shun Qi
Type 2 diabetes mellitus (T2DM) is an important risk factor for Alzheimer's disease (AD). Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been identified to be effective in T2DM treatment and neuroprotection. In the present study, we further explored the effects of a novel unimolecular GLP-1/GIP/Gcg triagonist on the cognitive behavior and cerebral pathology in the 7-month-old triple transgenic mouse model of AD (3xTg-AD), and investigated its possible electrophysiological and molecular mechanisms...
February 23, 2018: Hippocampus
https://www.readbyqxmd.com/read/29473928/a-novel-irni-pdir-c-core-shell-electrocatalyst-with-enhanced-activity-and-durability-for-the-hydrogen-oxidation-reaction-in-alkaline-anion-exchange-membrane-fuel-cells
#19
Bowen Qin, Hongmei Yu, Jia Jia, Chi Jun, Xueqiang Gao, Dewei Yao, Xinye Sun, Wei Song, Baolian Yi, Zhigang Shao
Herein, a novel non-platinum core-shell catalyst, namely, IrNi@PdIr/C was prepared via a galvanic replacement reaction; it exhibits enhanced hydrogen oxidation activity and excellent stability under alkaline conditions. Electrochemical experiments demonstrated that the mass and specific activities at 50 mV of IrNi@PdIr/C are 2.1 and 2.2 times that of commercial Pt/C in 0.1 M KOH at 298 K, respectively. Moreover, accelerated degradation tests have shown that the electrochemically active surface area (ECSA) of IrNi@PdIr/C reduces by only 5...
February 23, 2018: Nanoscale
https://www.readbyqxmd.com/read/29473926/emergence-of-photoluminescence-enhancement-of-eu-3-doped-biocl-single-crystalline-nanosheets-at-reduced-vertical-dimensions
#20
Yongjin Li, Rui Hu, Xiangzhou Zhang, Zhaoyi Yin, Jianbei Qiu, Zhengwen Yang, Zhiguo Song
Here, we report that a reduction in scale leads to an enhancement in the photoluminescence (PL) of Eu3+ doped BiOCl nanosheets, challenging the long-standing notion that PL is inevitably suppressed at a scale of tens of nanometers. The oriented depolarization effect of layered ferroelectrics was utilized for the first time to improve the PL efficiency of lanthanide doped nanomaterials. The probing effect of the electric dipole transitions of the Eu3+ ions and their PL measurements provides evidence that the depolarization field and the PL of Eu3+ ions increase synchronously as the thickness of the BiOCl single-crystalline nanosheets decreases from hundreds to tens of nanometers...
February 23, 2018: Nanoscale
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