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Jian Xie, Yan Feng, Ting Lin, Xiao-Yu Huang, Rui-Huan Gan, Yong Zhao, Bo-Hua Su, Lin-Can Ding, Lin She, Jiang Chen, Li-Song Lin, Xu Lin, Da-Li Zheng, You-Guang Lu
The cadherin-4 gene (CDH4) of the cadherin family encodes non-epithelial R-cadherin (R-cad); however, the function of this gene in different types of cancer remains controversial. In this study, we found higher expression of CDH4 mRNA in a salivary adenoid cystic carcinoma (SACC) cell line with low metastatic potential (SACC-83) than in a cell line with high metastatic potential (SACC-LM). By analyzing 67 samples of SACC tissues and 40 samples of paraneoplastic normal tissues, we found R-cad highly expressed in 100% of normal paraneoplastic tissue but only expressed in 64% of SACC tumor tissues (P<0...
October 22, 2016: Oncotarget
Chunxiang Feng, Jinqian Hu, Chang Liu, Shiliang Liu, Guiying Liao, Linjie Song, Xiaoyong Zeng
The increased incidence of stress urinary incontinence (SUI) in postmenopausal women has been proposed to be associated with a reduction in the level of 17-β estradiol (E2). E2 has also been shown to enhance the multi-differentiation ability of adipose-derived stem cells (ASCs) in vitro. However, studies on the potential value of E2 for tissue engineering in SUI treatment are rare. In the present study, we successfully fabricated myogenically differentiated ASCs (MD-ASCs), which were seeded onto a Poly(l-lactide)/Poly(e-caprolactone) electrospinning nano-scaffold, and incorporated E2 into the system, with the aim of improving the proliferation and myogenic differentiation of ASCs...
2016: PloS One
Yonghe Qi, Zhenchao Gao, Guangwei Xu, Bo Peng, Chenxuan Liu, Huan Yan, Qiyan Yao, Guoliang Sun, Yang Liu, Dingbin Tang, Zilin Song, Wenhui He, Yinyan Sun, Ju-Tao Guo, Wenhui Li
Hepatitis B virus (HBV) infection of hepatocytes begins by binding to its cellular receptor sodium taurocholate cotransporting polypeptide (NTCP), followed by the internalization of viral nucleocapsid into the cytoplasm. The viral relaxed circular (rc) DNA genome in nucleocapsid is transported into the nucleus and converted into covalently closed circular (ccc) DNA to serve as a viral persistence reservoir that is refractory to current antiviral therapies. Host DNA repair enzymes have been speculated to catalyze the conversion of rcDNA to cccDNA, however, the DNA polymerase(s) that fills the gap in the plus strand of rcDNA remains to be determined...
October 2016: PLoS Pathogens
Tae-Jin Song, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun, Min Kyung Chu
Although tension-type headache (TTH) is a frequent type of headache disorder and imposes a significant burden, there is scant information about the prevalence and impact of comorbid anxiety and depression among individuals with TTH. We investigated the prevalence and clinical impact of anxiety and depression among patients with TTH in the general population. We recruited Korean participants aged 19-69 years using a two-stage clustered random sampling method. To identify the presence of headache type, anxiety, and depression, we used a semi-structured interview using certain questionnaires...
2016: PloS One
Yee Song Ko, Frank A Nüesch, Dragan Damjanovic, Dorina M Opris
Copolymer nanoparticles with a highly polar repeating unit are blended in an elastic matrix and poled at elevated temperatures. The composite exhibits piezoelectricity due to the overall polarization imparted by the particles, which can be easily modulated thanks to the soft matrix.
October 26, 2016: Advanced Materials
Xi Song
In recent years, sociological research investigating grandparent effects in three-generation social mobility has proliferated, mostly focusing on the question of whether grandparents have a direct effect on their grandchildren's social attainment. This study hypothesizes that prior research has overlooked family structure as an important factor that moderates grandparents' direct effects. Capitalizing on a counterfactual causal framework and multigenerational data from the Panel Study of Income Dynamics, this study examines the direct effect of grandparents' years of education on grandchildren's years of educational attainment and heterogeneity in the effects associated with family structure...
October 25, 2016: Demography
Song Cai, Chuwen Ling, Jun Lu, Songwei Duan, Yingzhao Wang, Huining Zhu, Ruibang Lin, Liang Chen, Xingchang Pan, Muyi Cai, Huaiyu Gu
A primary pathogeny of epilepsy is excessive activation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPARs). To find potential molecules to inhibit AMPARs, high-throughput screening was performed in a library of tetrapeptides in silico. Computational results suggest that some tetrapeptides bind stably to the AMPAR. We aligned these sequences of tetrapeptide candidates with those from in vitro digestion of the trout skin protein. Among salmon-derived products, Glu-Gly-Ala-Arg (EGAR) showed a high biological affinity toward AMPAR when tested in silico...
October 25, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Hanping Li, Shuai Chang, Yang Han, Daomin Zhuang, Lin Li, Yongjian Liu, Siyang Liu, Zuoyi Bao, Wenfu Zhang, Hongbin Song, Taisheng Li, Jingyun Li
BACKGROUND: The widespread use of antiretroviral therapies has led to considerable concerns about the prevalence of drug-resistant, as transmission of drug-resistant (TDR) strains poses a challenge for the control of the HIV-1 epidemic. METHODS: We conducted an epidemiological study enrolling treatment-naïve HIV-1-positive subjects at the Peking Union Medical College Hospital since 1991. Drug resistance was determined by submitting the sequences to the Stanford University Network HIV-1 database...
October 26, 2016: BMC Infectious Diseases
DeCarlos E Taylor, János G Ángyán, Giulia Galli, Cui Zhang, Francois Gygi, Kimihiko Hirao, Jong Won Song, Kar Rahul, O Anatole von Lilienfeld, Rafał Podeszwa, Ireneusz W Bulik, Thomas M Henderson, Gustavo E Scuseria, Julien Toulouse, Roberto Peverati, Donald G Truhlar, Krzysztof Szalewicz
In the past decade, a number of approaches have been developed to fix the failure of (semi)local density-functional theory (DFT) in describing intermolecular interactions. The performance of several such approaches with respect to highly accurate benchmarks is compared here on a set of separation-dependent interaction energies for ten dimers. Since the benchmarks were unknown before the DFT-based results were collected, this comparison constitutes a blind test of these methods.
September 28, 2016: Journal of Chemical Physics
C Y Chen, D L Yu, B B Feng, L H Yao, X M Song, L G Zang, X Y Gao, Q W Yang, X R Duan
On HL-2A tokamak, supersonic molecular beam injection (SMBI) has been developed as a routine refueling method. The key components of the system are an electromagnetic valve and a conic nozzle. The valve and conic nozzle are assembled to compose the simplified Laval nozzle for generating the pulsed beam. The appurtenance of the system includes the cooling system serving the cooled SMBI generation and the in situ calibration component for quantitative injection. Compared with the conventional gas puffing, the SMBI features prompt response and larger fueling flux...
September 2016: Review of Scientific Instruments
Adam B Phillips, Zhaoning Song, Jonathan L DeWitt, Jon M Stone, Patrick W Krantz, John M Royston, Ryan M Zeller, Meghan R Mapes, Paul J Roland, Mark D Dorogi, Syed Zafar, Gary T Faykosh, Randy J Ellingson, Michael J Heben
We have developed a laser beam induced current imaging tool for photovoltaic devices and modules that utilizes diode pumped Q-switched lasers. Power densities on the order of one sun (100 mW/cm(2)) can be produced in a ∼40 μm spot size by operating the lasers at low diode current and high repetition rate. Using galvanostatically controlled mirrors in an overhead configuration and high speed data acquisition, large areas can be scanned in short times. As the beam is rastered, focus is maintained on a flat plane with an electronically controlled lens that is positioned in a coordinated fashion with the movements of the mirrors...
September 2016: Review of Scientific Instruments
Hongwei Song, Minghui Yang, Hua Guo
Vibrational excitations of reactants sometimes promote reactions more effectively than the same amount of translational energy. Such mode specificity provides insights into the transition-state modulation of reactivity and might be used to control chemical reactions. We report here a state-of-the-art full-dimensional quantum dynamical study of the hydrogen abstraction reaction H + NH3 → H2 + NH2 on an accurate ab initio based global potential energy surface. This reaction serves as an ideal candidate to study the relative efficacies of symmetric and degenerate antisymmetric stretching modes...
October 7, 2016: Journal of Chemical Physics
Shiqiang Song, Yinghao Zhai, Yong Zhang
Graphene/graphene oxide (GO)-based paper is attracting great interest owing to its multiple functionalities. In this study, we successfully synthesized a triblock copolymer by atom transfer radical polymerization (ATRP) method in terms of molecular design. The copolymer was comprised of polydimethylsiloxane (PDMS) and poly (glycidyl methacrylate) (PGMA) segments. To the copolymer, the PDMS segments provided flexible characteristic and the PGMA segments provided reactive groups and adhesiveness. Due to the above characteristics, the copolymer was used as an adhesive between the adjacent graphene oxide (GO) nanosheets for fabrication of GO/PDMS-PGMA papers...
October 26, 2016: ACS Applied Materials & Interfaces
Shu-Xia Guo, Xiang-Hui Zhang, Jing-Yu Zhang, Jia He, Yi-Zhong Yan, Jiao-Long Ma, Ru-Lin Ma, Heng Guo, La-Ti Mu, Shu-Gang Li, Qiang Niu, Dong-Sheng Rui, Mei Zhang, Jia-Ming Liu, Kui Wang, Shang-Zhi Xu, Xiang Gao, Yu-Song Ding
Most previous studies on metabolic syndrome (MetS) examined urban and high income settings. We thus investigated the prevalence of MetS among a multi-ethnic population living in a low income rural area and explored the use of visceral adiposity and anthropometric indicators to identify men and women with MetS. We recruited 10,029 individuals of nomadic Kazakhs, rural Uyghur and Han residents in Xinjiang, China. MetS was defined by the Joint Interim Statement criteria. The receiver operating characteristic curve (ROC) was used to compare the area under the ROC curve (AUC) of each index...
October 26, 2016: Scientific Reports
Gang Yong Song, Bei Huang, Hui Yuan Dong, Qiang Cheng, Tie Jun Cui
Acoustic metamaterials are artificial structures which can manipulate sound waves through their unconventional effective properties. Different from the locally resonant elements proposed in earlier studies, we propose an alternate route to realize acoustic metamaterials with both low loss and large refractive indices. We describe a new kind of acoustic metamaterial element with the fractal geometry. Due to the self-similar properties of the proposed structure, broadband acoustic responses may arise within a broad frequency range, making it a good candidate for a number of applications, such as super-resolution imaging and acoustic tunneling...
October 26, 2016: Scientific Reports
Longfei Jiang, Mengke Song, Li Yang, Dayi Zhang, Yingtao Sun, Zhenguo Shen, Chunling Luo, Gan Zhang
Bacterial communities of rhizospheric soils play an important role in the tolerance and uptake of metal-tolerant/hyperaccumulating plants to metals, e.g. the Cu-tolerant Elsholtzia splendens native to China. In this work, pyrosequencing of the bacterial 16S rRNA gene was firstly applied to investigate the rhizospheric bacterial community of E. splendens grown at Cu contaminated sites. The 47 phyla including 11 dominant phyla (>1%) in E. splendens rhizosphere were presented. The effects of Cu and other environmental factors (total organic carbon, total nitrogen and pH) on the rhizospheric bacterial community were studied comprehensively...
October 26, 2016: Scientific Reports
Nan Song, Hu Li, Fan Song, Wanzhi Cai
The Polyneoptera represents one of the earliest insect radiations, comprising the majority of hemimetabolous orders, in which many species have great economic importance. Here, we sequenced eleven mitochondrial genomes of the polyneopteran insects by using high throughput pooled sequencing technology, and presented a phylogenetic reconstruction for this group based on expanded mitochondrial genome data. Our analyses included 189 taxa, of which 139 species represent all the major polyneopteran lineages. Multiple results support the monophyly of Polyneoptera, the monophyly of Dictyoptera, and the monophyly of Orthoptera...
October 26, 2016: Scientific Reports
Chao Wu, Xinyue Li, Song Guo, Sek-Man Wong
In order to identify specific plant anti-viral genes related to the miRNA regulatory pathway, RNA-Seq and sRNA-Seq were performed using Arabidopsis WT and dcl1-9 mutant line. A total of 5,204 DEGs were identified in TCV-infected WT plants. In contrast, only 595 DEGs were obtained in the infected dcl1-9 mutant plants. GO enrichment analysis of the shared DEGs and dcl1-9 unique DEGs showed that a wide range of biological processes were affected in the infected WT plants. In addition, miRNAs displayed different patterns between mock and infected WT plants...
October 26, 2016: Scientific Reports
Young Bin Ji, Seung Jae Oh, Seok-Gu Kang, Jung Heo, Sang-Hoon Kim, Yuna Choi, Seungri Song, Hye Young Son, Se Hoon Kim, Ji Hyun Lee, Seung Joo Haam, Yong Min Huh, Jong Hee Chang, Chulmin Joo, Jin-Suck Suh
Gross total resection (GTR) of glioma is critical for improving the survival rate of glioma patients. One of the greatest challenges for achieving GTR is the difficulty in discriminating low grade tumor or peritumor regions that have an intact blood brain barrier (BBB) from normal brain tissues and delineating glioma margins during surgery. Here we present a highly sensitive, label-free terahertz reflectometry imaging (TRI) that overcomes current key limitations for intraoperative detection of World Health Organization (WHO) grade II (low grade), and grade III and IV (high grade) gliomas...
October 26, 2016: Scientific Reports
Alexandra E Livanos, Thomas U Greiner, Pajau Vangay, Wimal Pathmasiri, Delisha Stewart, Susan McRitchie, Huilin Li, Jennifer Chung, Jiho Sohn, Sara Kim, Zhan Gao, Cecily Barber, Joanne Kim, Sandy Ng, Arlin B Rogers, Susan Sumner, Xue-Song Zhang, Ken Cadwell, Dan Knights, Alexander Alekseyenko, Fredrik Bäckhed, Martin J Blaser
The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either continuous low-dose antibiotics or pulsed therapeutic antibiotics (PAT) early in life, mimicking childhood exposures...
August 22, 2016: Nature Microbiology
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