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https://www.readbyqxmd.com/read/29055275/three-dimensional-versus-two-dimensional-shear-wave-elastography-associations-of-mean-elasticity-values-with-prognostic-factors-and-tumor-subtypes-of-breast-cancer
#1
Hyun Jung Kang, Jin You Kim, Nam Kyung Lee, Ji Won Lee, You Seon Song, Shin Young Park, Jong Ki Shin
PURPOSE: To explore associations between prognostic factors and subtypes of invasive breast cancer (IBC) and elasticity values using three-dimensional (3D) and two-dimensional (2D) shear-wave elastography (SWE). MATERIALS AND METHODS: Mean elasticity values (kPa) of 121 IBCs were measured using both 3D and 2D SWE. Associations between these values and prognostic factors and subtypes were analyzed using linear regression model. RESULTS: In both 3D and 2D SWE, larger size and presence of lymphovascular invasion were independent factors influencing higher mean elasticity on multivariate analyses (all p values<0...
October 12, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29055167/genomic-differentiation-and-patterns-of-gene-flow-between-two-long-tailed-tit-species-aegithalos
#2
Dezhi Zhang, Gang Song, Bin Gao, Yalin Cheng, Yanhua Qu, Shaoyuan Wu, Shimiao Shao, Yongjie Wu, Per Alström, Fumin Lei
Patterns of heterogeneous genomic differentiation have been well documented between closely related species, with some highly differentiated genomic regions ("genomic differentiation islands") spread throughout the genome. Differential levels of gene flow are proposed to account for this pattern, as genomic differentiation islands are suggested to be resistant to gene flow. Recent studies have also suggested that genomic differentiation islands could be explained by linked selection acting on genomic regions with low recombination rates...
October 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29055099/regulation-of-glycosaminoglycan-biogenesis-is-critical-for-sensitive-period-dependent-vocal-ontogeny
#3
Caitlin P Mencio, Vy My Tran, Maritza V Quintero, Mamoru Koketsu, Franz Goller, Balagurunathan Kuberan
In the brain, the extracellular matrix (ECM) plays a central role during neural development and thus modulates critical-period regulated behavioral ontogeny. The major components of the ECM are glycosaminoglycans (GAGs) including chondroitin sulfate (CS). However, the specific roles of GAGs in behavioral development are largely unknown. It has been shown that xylosides affect the biological functions of GAGs through modulating GAG biosynthesis. Particularly, xylosides affect GAG biosynthesis through priming of GAG chains (priming activity), competing with endogenous core proteins that carry GAG initiation sites (decoy activity), or both...
October 21, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29055017/new-generation-nanomedicines-constructed-from-self-assembling-small-molecule-prodrugs-alleviate-cancer-drug-toxicity
#4
Hangxiang Wang, Zhongjie Lu, Lijiang Wang, Tingting Guo, Jiaping Wu, Jianqin Wan, Liqian Zhou, Hui Li, Zhen Li, Donghai Jiang, Penghong Song, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng
The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies for dose intensification to improve efficacy must also address tolerability. In addressing this issue, we have investigated a novel combinatorial strategy of reconstructing a drug molecule and using sequential drug-induced nanoassembly to fabricate supramolecular nanomedicines (SNM). Using cabazitaxel (CTX) as a target agent, we established that individual synthetic prodrugs tethered with polyunsaturated fatty acids were capable of recapitulating self-assembly behavior independent of exogenous excipients...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29054964/gene-expression-profiling-of-the-notch-ahr-il22-axis-at-homeostasis-and-in-response-to-tissue-injury
#5
Marc Weidenbusch, Severin Rodler, Shangqing Song, Simone Romoli, Julian A Marschner, Franziska Kraft, Alexander Holderied, Santosh Kumar, Shrikant R Mulay, Mohsen Honarpisheh, Satish Kumar Devarapu, Maciej Lech, Hans-Joachim Anders
Notch and Interleukin-22 signaling are known to regulate tissue homeostasis and response to injury in humans and mice, and the induction of endogenous arylhydrocarbon receptor ligands through Notch links the two pathways in a hierarchical fashion. However, in adults the species-, organ- and injury-specific gene expression of the Notch-AhR-IL22 axis components is unknown. We therefore performed gene expression profiling of DLL1, DLL3, DLL4, DLK1, DLK2, JAG1, JAG2, Notch1, Notch2, Notch3, Notch4, ADAM17/TACE, PSEN1, BSG/CD147, RBP-J, HES1, HES5, HEY1, HEYL, AHR, ARNT, ARNT2, CYP1A1, CYP24A1, IL22, IL22RA1, IL22RA2, IL10RB, and STAT3 under homeostatic conditions in 10 mature murine and human organs...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054962/expanded-alleles-of-the-fmr1-gene-are-related-to-unexplained-recurrent-miscarriages
#6
Xin-Hua Wang, Xiao-Hua Song, Tong Li, Xing-Hua Diao, Qing-Chun Li, Xiang-Hui Zhang, Yan-Lin Wang, Xiao-Hui Deng
Up to 50% of recurrent miscarriage cases in women occur without an underlying etiology. In the current prospective case-control study, we determined the impact of CGG trinucleotide expansions of the FMR1 gene in 49 women with unexplained recurrent miscarriages. Case group consisted of women with 2 or more unexplained consecutive miscarriages. Blood samples were obtained and checked for the presence of expanded alleles of the FMR1 gene using polymerase chain reaction. Patients harboring the expanded allele, with a threshold set to 40 repeats, were further evaluated by sequencing...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054864/heterogeneous-patterns-of-genetic-diversity-and-differentiation-in-european-and-siberian-chiffchaff-phylloscopus-collybita-abietinus-p-tristis
#7
Venkat Talla, Faheema Kalsoom, Daria Shipilina, Irina Marova, Niclas Backström
Identification of candidate genes for trait variation in diverging lineages and characterization of mechanistic underpinnings of genome differentiation are key steps towards understanding the processes underlying the formation of new species. Hybrid zones provide a valuable resource for such investigations since they allow for studying how genomes evolve as species exchange genetic material and for associating particular genetic regions with phenotypic traits of interest. Here we use whole-genome resequencing of both allopatric and hybridising populations of the European (Phylloscopus collybita abietinus) and the Siberian chiffchaff (P...
October 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29054828/cloning-and-expression-study-of-an-irf4a-gene-and-its-two-transcript-variants-in-turbot-scophthalmus-maximus
#8
Song Li, Guobin Hu, Zhipeng Chen, Lianfei Song, Guanjie Wang, Dahai Liu, Qiuming Liu
Interferon regulatory factor 4 (IRF4) is known to be involved in antiviral response as well as regulation of functional and developmental processes in lymphomyeloid cell lineages in mammals. In this study, the gene of IRF4a and its two transcript variants (named IRF4a1 and -2) were cloned from turbot, Scophthalmus maximus, the tissue distributions and in vivo immune responsive expression patterns of the two transcripts were subsequently examined. The Scophthalmus maximus (Sm)IRF4a gene is 8367 nucleotide (nt) in length, consisting of eight exons and seven introns...
October 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29054827/characterization-of-a-double-wap-domain-containing-protein-from-the-red-swamp-crayfish-procambarus-clarkii
#9
Hong-Wei Zhang, Xin Man, Yue Wang, Qi-Sheng Song, David Stanley, Kai-Min Hui, Xiao-Wen Zhang
Crustaceans express multiple whey acidic protein (WAP) domain containing proteins which are components of host immunity. In the present study, a new double WAP domain containing protein was identified from red swamp crayfish Procambarus clarkii, designated Pc-DWD. The ORF is 387 bp, encoding 128 amino acids consisting of signal peptide of 18 residues, and two tandem WAP domains of 38 and 44 residues. Multiple alignment indicates the presence of conserved motifs in both WAP domains, and phylogenetic analysis shows that Pc-DWD is a new member of the type-IV crustin family...
October 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29054740/cordycepin-inhibits-lps-induced-acute-lung-injury-by-inhibiting-inflammation-and-oxidative-stress
#10
Jiaji Lei, Youlei Wei, Pengcheng Song, Yongchao Li, Tianze Zhang, Qingjiang Feng, Guangquan Xu
Acute lung injury (ALI) is a common severe clinical syndrome in intensive care unit. Inflammation has been reported to play a critical role in the development of ALI. Cordycepin, an active component isolated from Cordyceps militaris, has been reported to have anti-inflammatory effects. However, the anti-inflammatory effects of cordycepin on LPS-induced ALI remain unclear. Therefore, in the present study, we assessed whether cordycepin could attenuate ALI induced by LPS. The mice were conditioned with cordycepin 1h before intranasal instillation of LPS...
October 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29054733/disrupted-ionic-homeostasis-in-ischemic-stroke-and-new-therapeutic-targets
#11
REVIEW
Hui-Jie Hu, Mingke Song
BACKGROUND: Stroke is a leading cause of long-term disability. All neuroprotectants targeting excitotoxicity have failed to become stroke medications. In order to explore and identify new therapeutic targets for stroke, we here reviewed present studies of ionic transporters and channels that are involved in ischemic brain damage. METHOD: We surveyed recent literature from animal experiments and clinical reports in the databases of PubMed and Elsevier ScienceDirect to analyze ionic mechanisms underlying ischemic cell damage and suggest promising ideas for stroke therapy...
October 17, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29054552/cross-talk-among-oxytocin-and-arginine-vasopressin-receptors-relevance-for-basic-and-clinical-studies-of-the-brain-and-periphery
#12
REVIEW
Zhimin Song, H Elliott Albers
Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery to influence a variety of physiological processes. Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions. Here, we review the increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other's canonical receptors (i.e., cross-talk) and examine the possibility that receptor cross-talk following the synaptic and non-synaptic release of OT and AVP contributes to their distinct roles in the brain and periphery...
October 17, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29054444/does-audience-affect-the-structure-of-warble-song-in-budgerigars-melopsittacus-undulatus
#13
Cole Tobin, Angela Medina-García, Gregory M Kohn, Timothy F Wright
In many bird species, male song functions both to defend a territory against other males and to attract a female mate. Male budgerigars (Melopsittacus undulatus) produce a song-like vocal signal, warble, that can be directed at either females or other males. Warble is a long, complex, low amplitude, and variable vocalization composed of different element types. While there is some evidence that warble can induce reproduction, the function of this signal is largely uncertain and it is unclear whether male- and female-directed warble differ in either function or structure...
October 17, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29054408/hdac6-deficiency-induces-apoptosis-in-mesenchymal-stem-cells-through-p53-k120-acetylation
#14
Song-Yi Park, Sophors Phorl, Suna Jung, Korm Sovannarith, Se-In Lee, Solhee Noh, Miae Han, Rema Naskar, Jae-Young Kim, Yun-Jaie Choi, Joo-Yong Lee
The acetylation of p53 is critical in modulating its pro-apoptotic roles. However, its regulatory mechanism and physiological significance are unclear. Here, we show HDAC6 negatively regulates pro-apoptotic acetylation of p53 at lysine residue 120 (K120) in mesenchymal stem cells (MSCs). The loss of HDAC6 expression in MSCs increases K120 acetylation of p53, which is successfully reversed by the wild type but not by catalytically dead HDAC6. Deletion of HDAC6 induces caspase-dependent apoptosis by promoting transactivation of Bax and suppression of Bcl-2...
October 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29054384/arthroscopic-subscapularis-repair-using-single-row-mattress-suture-technique-clinical-results-and-structural-integrity
#15
Jeung Yeol Jeong, Hai-Le Pan, Seung Yeop Song, Sang Min Lee, Jae Chul Yoo
BACKGROUND: Rupture of the subscapularis (SSC) tendon, isolated or combined, is rare, and the treatment modalities are controversial. The purpose of this study was to evaluate, by magnetic resonance imaging (MRI), the clinical outcomes and structural integrity of the SSC tendon after all-arthroscopic repair with single-row mattress suture for isolated or combined SSC tendon tears. METHODS: This study included 68 patients who underwent all-arthroscopic repair using single-row mattress suture for isolated or combined SSC tendon tears between April 2011 and January 2013...
October 17, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29054343/aster-yomena-extract-ameliorates-pro-inflammatory-immune-response-by-suppressing-nf-%C3%AE%C2%BAb-activation-in-raw-264-7-cells
#16
Kyung-A Hwang, Yu-Jin Hwang, Jin Song
BACKGROUND: Aster yomena, an edible vegetable, is a perennial herb found in Korea, China, Japan, and Siberia. It is used as folk medicine to treat cough, bronchial asthma, and insect bites. A. yomena was recently shown to have antioxidant and anti-asthmatic activities. Studies have not yet evaluated the anti-inflammatory effects of the various solvent fractions of A. yomena. We investigated the anti-inflammatory activity of various solvent fractions (hexane, dichloromethane, ethyl acetate, and butanol) from ethanol extract of A...
October 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29054295/diagnostic-accuracy-of-ultrasound-in-patients-with-gout-a-meta-analysis
#17
REVIEW
Young Ho Lee, Gwan Gyu Song
OBJECTIVE: This study aimed to evaluate the diagnostic performance of ultrasound (US) for patients with gout. METHODS: We searched the Medline, Embase, Pubmed, and Cochrane Library databases, and performed a meta-analysis of the diagnostic accuracy of US according to the double contour sign, tophus, snowstorm, or bony erosion in patients with gout. RESULTS: In total, 11 studies including 938 patients with gout, and 788 controls (patients with nongout inflammatory arthritis) were available for the meta-analysis...
September 28, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29054251/a-segmentation-method-based-on-hmrf-for-the-aided-diagnosis-of-acute-myeloid-leukemia
#18
Jie Su, Shuai Liu, Jinming Song
BACKGROUND AND OBJECTIVES: The diagnosis of acute myeloid leukemia (AML) is purely dependent on counting the percentages of blasts (>20%) in the peripheral blood or bone marrow. Manual microscopic examination of peripheral blood or bone marrow aspirate smears is time consuming and less accurate. The first and very important step in blast recognition is the segmentation of the cells from the background for further cell feature extraction and cell classification. In this paper, we aimed to utilize computer technologies in image analysis and artificial intelligence to develop an automatic program for blast recognition and counting in the aspirate smears...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29054189/development-of-a-diagnosis-model-for-coronary-artery-disease
#19
Hongzeng Xu, Zhiying Duan, Chi Miao, Song Geng, Yuanzhe Jin
BACKGROUND: The purpose of this study was to develop a coronary artery disease (CAD) prediction model that optimally estimates the pre-test probability of CAD for patients suspected of CAD. METHODS AND RESULTS: This retrospective, multi-centre study included 7360 consecutive patients (4678 men, 57.87±11.42 years old; 2682 women, 61.60±9.58 years old) who underwent coronary angiography for evaluation of CAD. A prediction model was fitted for diagnosis of CAD with the help of eight significant risk factors including sex, age, smoking status, diabetes, hypertension, dyslipidaemia, serum creatinine and angina...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29054110/mortality-burden-from-seasonal-influenza-and-2009-h1n1-pandemic-influenza-in-beijing-china-2007-2013
#20
REVIEW
Shuangsheng Wu, Zaihua Wei, Carolyn M Greene, Peng Yang, Jianting Su, Ying Song, A Danielle Iuliano, Quanyi Wang
BACKGROUND: Data about influenza mortality burden in northern China are limited. This study estimated mortality burden in Beijing associated with seasonal influenza from 2007-2013 and the 2009 H1N1 pandemic. METHODS: We estimated influenza-associated excess mortality by fitting a negative binomial model using weekly mortality data as the outcome of interest with the percent of influenza positive samples by type/subtype as predictor variables. RESULTS: From 2007 to 2013, an average of 2,375 (CI 1,002-8,688) deaths was attributed to influenza per season, accounting for 3% of all deaths...
October 20, 2017: Influenza and Other Respiratory Viruses
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