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https://www.readbyqxmd.com/read/29679875/impurity-profiling-of-varenicline-tartrate-by-lc-qtof-mass-spectrometric-techniques-during-drug-development
#1
Yuting Lu, Xiyang Sun, Fan Song, Lei Wang, Min Song, Taijun Hang
An LC-QTOF-MS method was developed for the separation and characterization of related substances in varenicline tartrate. The separation was established on an InertSustain C18 column (4.6 mm × 150 mm, 5 μm) by liner gradient elution using 0.05% trifluoroacetic acid as mobile phase A and acetonitrile as mobile phase B. The degradation studies were conducted under the ICH prescribed stress conditions. Varenicline tartrate was found to be unstable to alkaline, oxidative, thermal and photolytic stresses, while relatively stable under acid stress condition...
April 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29679817/a-survey-of-uranium-levels-in-urine-and-hair-of-people-living-in-a-coal-mining-area-in-yili-xinjiang-china
#2
Rehemanjiang Wufuer, Wenjuan Song, Daoyong Zhang, Xiangliang Pan, Geoffrey Michael Gadd
Recent reports have drawn attention to the uranium contamination arising from coal mining activities in the Yili region of Xinjiang, China due to the mixed distribution of uranium and coal mines, and some of the coal mines being associated with a high uranium content. In this study, we have collected water samples, solid samples such as soil, mud, coal, and coal ash, and hair and urine samples from local populations in order to evaluate the uranium level in this environment and its implications for humans in this high uranium coal mining area...
April 18, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29679758/validation-and-bioinformatic-analysis-of-propofol-induced-differentially-expressed-micrornas-in-primary-cultured-neural-stem-cells
#3
Yan Li, Youtan Liu, Jun Fan, Quan Zhou, Xiuling Song, Zhiyong Peng, Zaisheng Qin, Tao Tao
Propofol, a widely used intravenous anesthetic, was previously considered as a neuroprotective agent. Recently, however, accumulating evidence suggests that it may cause neurotoxicity, especially in the development of neural stem cells (NSCs). The potential mechanisms contributing to propofol-induced neurotoxicity during neurogenesis, such as those involving microRNAs (miRNAs), are still unknown. In this study, a total of 27 differentially expressed miRNAs were identified in our initial screen and 6 miRNAs were validated by qRT-PCR...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679633/influence-of-naringenin-on-the-biofilm-formation-of-streptococcus-mutans
#4
Jiaxi Yue, Hongye Yang, Siying Liu, Fangfang Song, Jingmei Guo, Cui Huang
OBJECTIVES: To evaluate the effect of naringenin on the biofilm formation of Streptococcus mutans (S. mutans), and to investigate its mechanisms of action and biological toxicity. METHODS: Minimum inhibitory concentrations, growth curves, and biofilm inhibition rates of naringenin were determined to assess its antimicrobial effect on S. mutans. The morphology of S. mutans and the structure of biofilm were observed by FESEM and CLSM. Bacterial aggregation, bacterial surface hydrophobicity, and real-time PCR for gtfB, gtfC, comD, comE, and luxS mRNA expression were assessed to preliminarily investigate the mechanisms of action...
April 18, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29679614/the-regulation-of-birdsong-by-testosterone-multiple-time-scales-and-multiple-sites-of-action
#5
REVIEW
Beau A Alward, Charlotte A Cornil, Jacques Balthazart, Gregory F Ball
Sex steroid hormones act during early development to shape the circuitry upon which these same hormones act in adulthood to control behavioral responses to various stimuli. The "organizational" vs. "activational" distinction was proposed to explain this temporal difference in hormone action. In both of these cases steroids were thought to act genomically over a time-scale of days to weeks. However, sex steroids can affect behavior over short (e.g., seconds or minutes) time-scales. Here, we discuss how testosterone controls birdsong via actions at different sites and over different time-scales, with an emphasis on this process in canaries (Serinus canaria)...
April 18, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29679508/motion-compensated-image-reconstruction-vs-post-reconstruction-correction-in-respiratory-binned-spect-with-standard-and-reduced-dose-acquisitions
#6
Chao Song, Yongyi Yang, Wenyuan Qi, Miles N Wernick, P Hendrik Pretorius, Michael A King
PURPOSE: Cardiac perfusion images in single photon emission computed tomography (SPECT) can suffer from respiratory motion blur. We investigated a reconstruction approach for correcting respiratory motion in respiratory-binned acquisitions and assessed the benefit of this approach in both standard dose and reduced dose. METHODS: We modeled the acquired data from different respiratory bins by a joint probability distribution which was parameterized with respect to a common reference bin...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29679449/value-of-intravascular-ultrasound-in-guiding-coronary-interventions
#7
REVIEW
Hae Geun Song, Soo-Jin Kang, Gary S Mintz
There has been great effort to improve clinical outcome in percutaneous treatment for coronary artery disease. Complementary to coronary angiography, intravascular ultrasound (IVUS) provides in vivo tomographic anatomic information, enabling to evaluate from the lumen to the vessel wall. As a result, IVUS has had a pivotal role to understand pathophysiology of coronary artery disease and improve clinical outcome. It provides preprocedural information to evaluate stenosis severity and plaque characteristics and helps with optimal stent deployment, minimizing underexpansion and geographic miss that are the major mechanisms of stent failure...
April 2018: Echocardiography
https://www.readbyqxmd.com/read/29679347/pre-emptive-treatment-of-hcv-after-living-donor-liver-transplantation-with-direct-acting-antiviral-agents
#8
Jinmin Jung, Jae Hyun Kwon, Gi-Won Song, Eun-Young Tak, Vavara A Kirchner, Sung-Gyu Lee
BACKGROUND: Hepatitis C virus (HCV) universally recurs after liver transplantation (LT). Although the introduction of direct-acting antiviral agents (DAAs) has revolutionized the treatment of HCV infection, no optimal treatment for HCV recurrence after LT has been developed. METHODS: This study retrospectively evaluated the efficacy of DAAs as a pre-emptive treatment for recurrent HCV infection after living donor liver transplantation (LDLT). From January 2010 to December 2016, 70 patients received pegylated interferon (PegIFN) and 35 patients were treated with DAA-based regimens to treat recurrent HCV after LDLT...
April 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29679292/preparation-and-optimization-lipid-nanocapsules-to-enhance-the-antitumor-efficacy-of-cisplatin-in-hepatocellular-carcinoma-hepg2-cells
#9
Qingqing Zhai, Hailong Li, Yanlin Song, Ruijiao Wu, Chuanfang Tang, Xiaodong Ma, Zhihao Liu, Jinyong Peng, Jianbin Zhang, Zeyao Tang
This work aimed to develop and optimize several lipid nanocapsule formulations (LNCs) to encapsulate cisplatin (CDDP) for treatment of hepatocellular carcinoma. By comparing the effect of oil/surfactant ratio, lecithin content, and oil/surfactant type on LNC characteristics, two LNCs were selected as optimal formulations: HS15-LNC (Solutol HS 15/MCT/lecithin, 54.5:42.5:3%, w/w) and EL-LNC (Cremophor EL/MCT/lecithin, 54.5:42.5:3%, w/w). Both LNCs could effectively encapsulate CDDP with the encapsulation efficiency of 73...
April 20, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29679278/overexpression-of-modified-human-tr%C3%AE-1-suppresses-the-growth-of-hepatocarcinoma-sk-hep1-cells-in-vitro-and-in-xenograft-models
#10
Xiaoxiang Peng, Yuntao Zhou, Yanli Sun, Wei Song, Xiangying Meng, Chunling Zhao, Ronglan Zhao
Association studies suggest that TRβ1 functions as a tumor suppressor. Thyroid hormone receptors (TRs) mediate transcriptional responses through a highly conserved DNA-binding domain (DBD). We previously constructed an artificially modified human TRβ1 (m-TRβ1) via the introduction of a 108-bp exon sequence into the corresponding position of the wild-type human TRβ1 (TRβ1) DBD. Studies confirmed that m-TRβ1 was functional and could inhibit the proliferation of breast cancer MDA-MB-468 cells in vitro. To understand the role of m-TRβ1 in liver tumor development, we adopted a gain-of-function approach by stably expressing TRβ (m-TRβ1 and TRβ1) genes in a human hepatocarcinoma cell line, SK-hep1 (without endogenous TRβ), and then evaluated the effects of the expressed TRβ on cancer cell proliferation, migration, and tumor growth in cell-based studies and xenograft models...
April 20, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29679179/isolation-and-characterization-of-phosphofungi-and-screening-of-their-plant-growth-promoting-activities
#11
Xiaohui Wang, Changdong Wang, Junkang Sui, Zhaoyang Liu, Qian Li, Chao Ji, Xin Song, Yurong Hu, Changqian Wang, Rongbo Sa, Jiamiao Zhang, Jianfeng Du, Xunli Liu
Rhizospheric microorganisms can increase phosphorus availability in the soil. In this regard, the ability of phosphofungi to dissolve insoluble phosphorus compounds is greater than that of phosphate-solubilizing bacteria. The aim of the current study was to identify efficient phosphofungi that could be developed as commercial microbial agents. Among several phosphate-solubilizing fungal isolates screened, strain CS-1 showed the highest phosphorus-solubilization ability. Based on phylogenetic analysis of the internal transcribed spacer region sequence, it was identified as Aspergillus niger...
April 20, 2018: AMB Express
https://www.readbyqxmd.com/read/29679088/complications-and-pain-in-obstructive-sleep-apnoea-comparing-single-and-multilevel-surgery
#12
Ching Yee Chan, Hong Juan Han, Weng Kit Lye, Song Tar Toh
INTRODUCTION: This study aimed to investigate differences in the complication rate and postoperative pain score between single and multilevel surgery performed on patients with obstructive sleep apnoea. MATERIALS AND METHODS: A retrospective analysis was performed on patients with obstructive sleep apnoea who underwent surgery in a tertiary referral centre over 3 years. Patients who underwent single-level nasal, palatal or tongue surgery were compared with patients who underwent concurrent multilevel surgery of 2 or 3 levels...
March 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29679008/improving-wood-properties-for-wood-utilization-through-multi-omics-integration-in-lignin-biosynthesis
#13
Jack P Wang, Megan L Matthews, Cranos M Williams, Rui Shi, Chenmin Yang, Sermsawat Tunlaya-Anukit, Hsi-Chuan Chen, Quanzi Li, Jie Liu, Chien-Yuan Lin, Punith Naik, Ying-Hsuan Sun, Philip L Loziuk, Ting-Feng Yeh, Hoon Kim, Erica Gjersing, Todd Shollenberger, Christopher M Shuford, Jina Song, Zachary Miller, Yung-Yun Huang, Charles W Edmunds, Baoguang Liu, Yi Sun, Ying-Chung Jimmy Lin, Wei Li, Hao Chen, Ilona Peszlen, Joel J Ducoste, John Ralph, Hou-Min Chang, David C Muddiman, Mark F Davis, Chris Smith, Fikret Isik, Ronald Sederoff, Vincent L Chiang
A multi-omics quantitative integrative analysis of lignin biosynthesis can advance the strategic engineering of wood for timber, pulp, and biofuels. Lignin is polymerized from three monomers (monolignols) produced by a grid-like pathway. The pathway in wood formation of Populus trichocarpa has at least 21 genes, encoding enzymes that mediate 37 reactions on 24 metabolites, leading to lignin and affecting wood properties. We perturb these 21 pathway genes and integrate transcriptomic, proteomic, fluxomic and phenomic data from 221 lines selected from ~2000 transgenics (6-month-old)...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29678908/the-lim-homeodomain-protein-isl1-mediates-the-function-of-tcf7l2-in-pancreatic-beta-cells
#14
Weijuan Shao, Vivian Szeto, Zhuolun Song, Lili Tian, Zhong-Ping Feng, Cristina M Nostro, Tianru Jin
Pancreatic β-cell Tcf7l2 deletion or its functional knockdown suggested the essential role of this Wnt pathway effector in controlling insulin secretion, glucose homeostasis, and β-cell gene expression. As the LIM homeodomain protein Isl1 is a suggested Wnt pathway downstream target, we hypothesize that it mediates metabolic functions of Tcf7l2. We aimed to determine the role of Isl1 in mediating the function of Tcf7l2 and the incretin hormone GLP-1 in pancreatic β-cells. Effect of dominant negative TCF7L2 (TCF7L2DN) mediated Wnt pathway functional knockdown on Isl1 expression was determined in βTCFDN mouse islets and in the rat insulinoma cell line INS-1 832/13...
April 20, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29678850/cryopreservation-of-genotyped-abo-subgroup-rbcs-for-quality-assurance-of-abo-grouping-reagents
#15
Sinyoung Kim, Sungwook Song, Hyun Ok Kim
BACKGROUND: Quality assurance of newly developed or manufactured blood grouping reagents with reagent red blood cells (RBCs) is crucial in the process of product approval by governmental agency. However, RBCs with rare blood group are not easily available in the fresh state. We investigated the feasibility of cryopreserved and genotyped ABO subgroup RBC reagents for quality assurance purpose. METHODS: We obtained RBCs from 10 volunteers with ABO subgroup phenotypes...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678628/poria-cocos-polysaccharide-attenuates-rankl-induced-osteoclastogenesis-by-suppressing-nfatc1-activity-and-phosphorylation-of-erk-and-stat3
#16
Dezhi Song, Zhen Cao, Jennifer Tickner, Heng Qiu, Chao Wang, Kai Chen, Ziyi Wang, Chunyu Guo, Shiwu Dong, Jiake Xu
Pathological fractures caused by osteolytic lesions seriously threaten the health of patients. Osteoclasts play important roles in bone resorption whose hyperfunction are closely related to osteolytic lesions. Studies on osteoclast differentiation and function assist in the prevention of excessive bone loss associated diseases. We screened a variety of natural compounds with anti-inflammatory effect and found that poria cocos polysaccharide (PCP) inhibited RANKL-induced osteoclast formation and bone resorption via TRAcP staining, immunofluorescence, RT-PCR and western blot...
April 17, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29678567/germ-cell-specific-apoptosis-by-extracellular-clusterin-in-cryptorchid-dog-testes
#17
Hyunjhung Jhun, Hyun-Jung Park, Ran Lee, Hyuk Song, Tai-Young Hur, Seunghoon Lee, Jin-Ki Park, Won-Young Lee
Mammalian testes are maintained at a relatively lesser temperature than the abdominal region so that normal spermatogenesis can occur. Germ cell apoptosis has resulted in heat-damaged testes that occurs as a result of cryptorchidism, but the mechanism is not yet fully understood. To elucidate the cause of germ-cell death by cryptorchidism, cryptorchidism was surgically induced in dog testes and histological and molecular analyses were performed. Histological data indicated that the seminiferous tubules of cryptorchid testes and epididymis contained fewer germ cells...
April 13, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29678554/structure-of-escherichia-coli-arginyl-trna-synthetase-in-complex-with-trna-arg-pivotal-role-of-the-d-loop
#18
Preyesh Stephen, Sheng Ye, Ming Zhou, Jian Song, Rongguang Zhang, En-Duo Wang, Richard Giegé, Sheng-Xiang Lin
Aminoacyl-tRNA synthetases are essential components in protein biosynthesis. Arginyl-tRNA synthetase (ArgRS) belongs to the small group of aaRSs requiring cognate tRNA for amino acid activation. The crystal structure of Escherichia coli (Eco) ArgRS has been solved in complex with tRNAArg at 3.0Å resolution. With this first bacterial tRNA complex, we are attempting to bridge the gap existing in structure-function understanding in prokaryotic tRNAArg recognition. The structure shows a tight binding of tRNA on the synthetase through the identity determinant A20 from the D-loop, a tRNA recognition snapshot never elucidated structurally...
April 17, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29678550/low-level-shear-stress-promotes-migration-of-liver-cancer-stem-cells-via-the-fak-erk1-2-signalling-pathway
#19
Jinghui Sun, Qing Luo, Lingling Liu, Guanbin Song
Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known about the effects of shear stress on the migration of liver cancer stem cells (LCSCs). Here, we studied the effects of shear stress that are generated from a parallel plated flow chamber system, on LCSC migration and the activation of focal adhesion kinase (FAK) and extracellular signal regulated kinase1/2 (ERK1/2), using transwell assay and western blot, respectively...
April 17, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29678482/verification-of-eye-lens-dose-in-imrt-by-mosfet-measurement
#20
Xuetao Wang, Guangjun Li, Jianling Zhao, Ying Song, Jianghong Xiao, Sen Bai
The eye lens is recognized as one of the most radiosensitive structures in the human body. The widespread use of intensity-modulated radiotherapy (IMRT) complicates dose verification and necessitates high standards of dose computation. The purpose of this work was to assess the computed dose accuracy of eye lens through measurements using a metal-oxide-semiconductor field-effect transistor (MOSFET) dosimetry system. Sixteen clinical IMRT plans of head and neck patients were copied to an anthropomorphic head phantom...
April 17, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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