A M Oelschlegel, R Bhattacharjee, P Wenk, K Harit, H-J Rothkötter, S P Koch, P Boehm-Sturm, K Matuschewski, E Budinger, D Schlüter, J Goldschmidt, G Nishanth
Sequestration of infected red blood cells (iRBCs) in the microcirculation is a hallmark of cerebral malaria (CM) in post-mortem human brains. It remains controversial how this might be linked to the different disease manifestations, in particular brain swelling leading to brain herniation and death. The main hypotheses focus on iRBC-triggered inflammation and mechanical obstruction of blood flow. Here, we test these hypotheses using murine models of experimental CM (ECM), SPECT-imaging of radiolabeled iRBCs and cerebral perfusion, MR-angiography, q-PCR, and immunohistochemistry...
March 16, 2024: Nature Communications