Sadegh Moradi Vastegani, Somayeh Hajipour, Alireza Sarkaki, Zahra Basir, Yaghoob Farbood, Kowsar Bavarsad, Seyed Esmaeil Khoshnam
It has been consistently found that exposure to ambient air pollution, such as particulate matter (PM), results in cognitive impairments and mental disorders. This study aimed to investigate the possible neuroprotective effects of curcumin, a polyphenol compound, on the neurobehavioral deficits and to identify the role of oxidative stress in dusty PM exposure rats. Rats received curcumin (50 mg/kg, daily, gavage, 2 weeks) 30 min before placing animals in a clean air chamber (≤ 150 µg/m3 , 60 min daily, 2 weeks) or ambient dusty PM chamber (2000-8000 µg/m3 , 60 min daily, 2 weeks)...
January 28, 2023: Neurochemical Research