keyword
https://read.qxmd.com/read/37632838/curcumin-alleviates-orofacial-allodynia-and-improves-cognitive-impairment-via-regulating-hippocampal-synaptic-plasticity-in-a-mouse-model-of-trigeminal-neuralgia
#21
JOURNAL ARTICLE
Hong-Wei Zhi, Yu-Zhi Jia, Huai-Qian Bo, Hai-Tao Li, Si-Shuo Zhang, Ya-Han Wang, Jie Yang, Ming-Zhe Hu, Hong-Yun Wu, Wen-Qiang Cui, Xiang-Dong Xu
OBJECTIVE: Cognitive impairment, one of the most prevalent complications of trigeminal neuralgia, is troubling for patients and clinicians due to limited therapeutic options. Curcumin shows antinociception and neuroprotection pharmacologically, suggesting that it may have therapeutic effect on this complication. This study aimed to investigate whether curcumin alleviates orofacial allodynia and improves cognitive impairment by regulating hippocampal CA1 region synaptic plasticity in trigeminal neuralgia...
August 25, 2023: Aging
https://read.qxmd.com/read/37603263/over-the-counter-supplements-for-memory-a-review-of-available-evidence
#22
REVIEW
Haley Hersant, Sean He, Peter Maliha, George Grossberg
In 2021, the Global Brain Health Supplement Industry Market size was valued at US$7.6 billion. It is predicted to increase to US$15.59 billion by 2030. Memory and its enhancement are a segment of the market that comprised the highest global revenue share in 2021. In the USA alone, dietary supplement sales reached US$18 billion in 2018. The US Food and Drug Administration (FDA) does not have the authority to approve dietary supplements' safety, effectiveness, or labeling before products go on the market...
September 2023: CNS Drugs
https://read.qxmd.com/read/37580934/effects-of-curcumin-on-memory-hippocampal-acetylcholine-level-and-neuroapoptosis-in-repeated-cerebral-ischemia-rat-model
#23
JOURNAL ARTICLE
- Baiyu Li, - Shuyan Liu, - Taowen Ren, - BoYangYan
The aim of this study was to determine the protective effects of curcumin on memory, hippocampal acetylcholine level and apoptosis in a rat model of repeated cerebral ischemia. Male Wistar rats were divided into sham rats that received saline and the other 3 groups underwent 4-vessel occlusion brain ischemia (4VOI), received oral administration of either saline or curcumin at doses rate of 25mg/kg/day and 50mg/kg/day for 7 days. Memory function was evaluated by eight-arm radial maze task and Morris water maze (MWM) test, Acetylcholine release (ACh) in the dorsal hippocampus was evaluated by microdialysis-HPLC) and neuron apoptosis was investigated by terminal deoxynucleotidyltransferase mediated fluorescein-deoxyuridine triphosphate nick-end labeling...
May 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/37576278/discovery-of-drug-lead-compounds-for-anti-alzheimer-s-disease-on-the-basis-of-synaptic-plasticity
#24
JOURNAL ARTICLE
Heyu Wang, Quan Tang, Yanyu Xue, Xiaoqian Gao, Yan Zhang
Alzheimer's disease (AD) is a progressive neurodegenerative disease commonly seen in the middle-aged and the elder. Its clinical presentations are mainly memory impairment and cognitive impairment. Its cardinal pathological features are the deposition of extracellular Amyloid-β (Aβ), intracellular neurofibrillary tangles and synaptic dysfunction. The etiology of AD is complex and the pathogenesis remains unclear. Having AD would lead to awful living experience of it's patients, which may be a burden to the patient even to the public health care system...
August 2023: Heliyon
https://read.qxmd.com/read/37566247/effect-of-curcumin-on-cognitive-behavior-and-pathological-characteristics-of-the-hippocampus-in-mice-with-inherent-alzheimer-s-disease
#25
JOURNAL ARTICLE
M J Zhang, J H Zhong, X J Yi
This study examined the effect of curcumin on pathological manifestations and clearance of amyloid β peptide (Aβ) in the hippocampus of 8-month-old transgenic APP/PS1 mice with inherent Alzheimer's disease. APP/PS1 mice and the age-matched wild-type controls were subjected to 3 behavioral tests: open field, new object recognition, and Morris water maze. Expression of Aβ, APP, CTF, BACE1, IDE, NEP, and LRP1 proteins in the extracted hippocampal tissue was evaluated by Western blotting. The distribution and the quantity of amyloid plaques and the spread of microglia in the hippocampus were determined by immunofluorescence...
August 11, 2023: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/37542120/combination-of-epigallocatechin-3-gallate-and-curcumin-improves-d-galactose-and-normal-aging-associated-memory-impairment-in-mice
#26
JOURNAL ARTICLE
Md Ashrafur Rahman, Arif Anzum Shuvo, Md Mehedi Hasan Apu, Monisha Rani Bhakta, Farzana Islam, Md Atiqur Rahman, Md Rabiul Islam, Hasan Mahmud Reza
Previously, we observed curcumin improves aging-associated memory impairment in D-galactose (D-gal) and normal-aged (NA) mice. Evidence showed that multiple agents can be used in managing aging-induced memory dysfunction, drawn by the contribution of several pathways. Curcumin and Epigallocatechin 3 gallate (EGCG) combination substantially reduced the oxidative stress that commonly mediates aging. This study examined the combined effect of EGCG and curcumin on memory improvement in two recognized models, D-gal and normal-aged (NA) mice...
August 4, 2023: Scientific Reports
https://read.qxmd.com/read/37535209/correction-to-modulatory-role-of-curcumin-on-cobalt%C3%A2-induced-memory-deficit-hippocampal-oxidative-damage-astrocytosis-and-nrf2-expression
#27
Rademene S Oria, Godson E Anyanwu, Emmanuel A Esom, Johnson N Nto, Amechi U Katchy, Augustine U Agu, Omamuyovwi M Ijomone
No abstract text is available yet for this article.
August 3, 2023: Neurotoxicity Research
https://read.qxmd.com/read/37278037/the-effects-of-curcumin-on-brain-derived-neurotrophic-factor-expression-in-neurodegenerative-disorders
#28
JOURNAL ARTICLE
Shabnam Radbakhsh, Alexandra E Butler, Seyed Adel Moallem, Amirhossein Sahebkar
Brain-Derived Neurotrophic Factor (BDNF) is a crucial molecule implicated in plastic modifications related to learning and memory. The expression of BDNF is highly regulated, which can lead to significant variability in BDNF levels in healthy subjects. Changes in BDNF expression might be associated with neuropsychiatric diseases, particularly in structures important for memory processes, including the hippocampus and parahippocampal areas. Curcumin is a natural polyphenolic compound that has great potential for the prevention and treatment of age-related disorders by regulating and activating the expression of neural protective proteins such as BDNF...
June 2, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37239093/effect-of-curcumin-and-coenzyme-q10-alone-and-in-combination-on-learning-and-memory-in-an-animal-model-of-alzheimer-s-disease
#29
JOURNAL ARTICLE
Pramod Kumar, Aarti Singh, Anurag Kumar, Rahul Kumar, Rishi Pal, Amod Kumar Sachan, Rakesh Kumar Dixit, Rajendra Nath
The most frequent neurodegenerative illness among senior people and the main cause of dementia is Alzheimer's disease. The present dementia medications available only help with the symptoms of cognitive deficits and have several negative effects. The current study's goal is to assess the effects of curcumin and coenzyme Q10, two herbal medicines, both separately and in combination, on learning and memory before comparing them to the industry standard drug. A total of 42 adult healthy Wistar rats were used in our study...
May 11, 2023: Biomedicines
https://read.qxmd.com/read/37119345/efficacy-of-curcumin-on-cognitive-function-scores-in-women-with-premenstrual-syndrome-and-dysmenorrhea-a-triple-blind-placebo-controlled-clinical-trial
#30
RANDOMIZED CONTROLLED TRIAL
Afsane Bahrami, Amir Masoud Jafari-Nozad, Samira Karbasi, Malaksima Ayadilord, Gordon A Ferns
OBJECTIVE: To assess the efficacy of a curcumin supplementation on cognitive abilities in women suffering from premenstrual syndrome (PMS) and dysmenorrhea. METHODS: A randomized, triple-blind, placebo-controlled trial was conducted from December 2019 to March 2020. A total of 124 women who had both PMS and dysmenorrhea were enrolled, and were equally and randomly assigned to the curcumin group or placebo group, 62 cases in each. Each subject received either a capsule containing 500 mg of curcuminoid, or a placebo daily, for 10 days (7 days before and until 3 days after the onset of menstrual bleeding) over 3 menstrual cycles...
May 2023: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/37109528/phytochemicals-a-promising-alternative-for-the-prevention-of-alzheimer-s-disease
#31
REVIEW
Bhupendra Koul, Usma Farooq, Dhananjay Yadav, Minseok Song
Alzheimer's disease (AD) is a neurological condition that worsens with ageing and affects memory and cognitive function. Presently more than 55 million individuals are affected by AD all over the world, and it is a leading cause of death in old age. The main purpose of this paper is to review the phytochemical constituents of different plants that are used for the treatment of AD. A thorough and organized review of the existing literature was conducted, and the data under the different sections were found using a computerized bibliographic search through the use of databases such as PubMed, Web of Science, Google Scholar, Scopus, CAB Abstracts, MEDLINE, EMBASE, INMEDPLAN, NATTS, and numerous other websites...
April 12, 2023: Life
https://read.qxmd.com/read/36947339/low-dose-curcumin-enhances-hippocampal-neurogenesis-and-memory-retention-in-young-mice
#32
JOURNAL ARTICLE
Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Lee
Adult neurogenesis generates new functional neurons from adult neural stem cells in various regions, including the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of hippocampal dentate gyrus (DG). Available evidence shows hippocampal neurogenesis can be negatively or positively regulated by dietary components. In a previous study, we reported that curcumin (diferuloylmethane; a polyphenolic found in curry spice) stimulates the proliferation of embryonic neural stem cells (NSCs) by activating adaptive cellular stress responses...
May 2023: Archives of Pharmacal Research
https://read.qxmd.com/read/36936437/development-of-alternative-herbals-remedy-for-gastric-cancer-based-on-transcriptomic-analysis-of-immune-infiltration-and-ferroptosis
#33
JOURNAL ARTICLE
Mingyue Li, Jie Tao, Rui Qian, Feng Jiang, Yinzhi Song, Zhicong Zeng, Changlong Cai
Objective: Screening out potential herbal medicines and herbal ingredients for the treatment of gastric cancer based on transcriptomic analysis of immune infiltration and ferroptosis. Methods: Gene expression profiles of gastric tumour tissues and normal tissue samples were obtained from the GEO database and the samples were analysed for immune cell infiltration condition and differential expressed genes of ferroptosis. Key genes were screened by protein-protein interaction (PPI) and enrichment analysis, and molecular docking was used to predict and preliminary validate potential herbal and traditional Chinese medicine components for gastric cancer based on the key genes...
2023: Frontiers in Genetics
https://read.qxmd.com/read/36856916/protective-effects-of-curcumin-and-ginkgo-biloba-extract-combination-on-a%C3%A2-new-model-of-alzheimer-s-disease
#34
JOURNAL ARTICLE
Abdel-Azim Assi, Magda M Y Farrag, Dalia M Badary, Essmat A H Allam, Mariam A Nicola
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative illnesses, and yet, no workable treatments have been discovered to prevent or reverse AD. Curcumin (CUR), the major polyphenolic compound of turmeric (Curcuma longa) rhizomes, and Ginkgo biloba extract (GBE) are natural substances derived from conventional Chinese herbs that have long been shown to provide therapeutic advantages for AD. The uptake of curcumin into the brain is severely restricted by its low ability to cross the blood-brain barrier (BBB)...
March 1, 2023: Inflammopharmacology
https://read.qxmd.com/read/36829952/potential-of-nano-antioxidants-and-nanomedicine-for-recovery-from-neurological-disorders-linked-to-long-covid-syndrome
#35
REVIEW
Thelma Akanchise, Angelina Angelova
Long-term neurological complications, persisting in patients who cannot fully recover several months after severe SARS-CoV-2 coronavirus infection, are referred to as neurological sequelae of the long COVID syndrome. Among the numerous clinical post-acute COVID-19 symptoms, neurological and psychiatric manifestations comprise prolonged fatigue, "brain fog", memory deficits, headache, ageusia, anosmia, myalgias, cognitive impairments, anxiety, and depression lasting several months. Considering that neurons are highly vulnerable to inflammatory and oxidative stress damages following the overproduction of reactive oxygen species (ROS), neuroinflammation and oxidative stress have been suggested to dominate the pathophysiological mechanisms of the long COVID syndrome...
February 6, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36708454/curcumin-ameliorates-neurobehavioral-deficits-in-ambient-dusty-particulate-matter-exposure-rats-the-role-of-oxidative-stress
#36
JOURNAL ARTICLE
Sadegh Moradi Vastegani, Somayeh Hajipour, Alireza Sarkaki, Zahra Basir, Yaghoob Farbood, Kowsar Bavarsad, Seyed Esmaeil Khoshnam
It has been consistently found that exposure to ambient air pollution, such as particulate matter (PM), results in cognitive impairments and mental disorders. This study aimed to investigate the possible neuroprotective effects of curcumin, a polyphenol compound, on the neurobehavioral deficits and to identify the role of oxidative stress in dusty PM exposure rats. Rats received curcumin (50 mg/kg, daily, gavage, 2 weeks) 30 min before placing animals in a clean air chamber (≤ 150 µg/m3 , 60 min daily, 2 weeks) or ambient dusty PM chamber (2000-8000 µg/m3 , 60 min daily, 2 weeks)...
January 28, 2023: Neurochemical Research
https://read.qxmd.com/read/36703027/brain-targeted-curcumin-loaded-turmeric-oil-microemulsion-protects-against-trimethyltin-induced-neurodegeneration-in-adult-zebrafish-a-pharmacokinetic-and-pharmacodynamic-insight
#37
JOURNAL ARTICLE
Suraj More, Atmaram Pawar
PURPOSE: Aromatic turmerone, a major constituent of turmeric oil, has been recently reported for proliferation of neural stem cell showing great potential for effective treatment in neurodegenerative disorders. However, its effect as oral brain targeted formulation for neuroprotection has not yet reported. The objective of the study was to investigate the pharmacokinetic of curcumin loaded turmeric oil microemulsion for brain targeting and probing the protective effect against trimethyltin induced neurodegeneration in adult zebrafish...
January 26, 2023: Pharmaceutical Research
https://read.qxmd.com/read/36701014/curcumin-attenuates-memory-impairments-and-long-term-potentiation-deficits-by-damping-hippocampal-inflammatory-cytokines-in-lipopolysaccharide-challenged-rats
#38
JOURNAL ARTICLE
Somayeh Hajipour, Sadegh Moradi Vastegani, Alireza Sarkaki, Zahra Basir, Seyedeh Parisa Navabi, Yaghoob Farbood, Seyed Esmaeil Khoshnam
Neuroinflammation is a key pathological event triggering neurodegenerative process, resulting in neurologic sequelae. Curcumin (cur) has recently received increasing attention due to its anti-inflammatory properties. Therefore, we investigated the protective effects of curcumin on lipopolysaccharide (LPS)-induced memory impairments, long-term potentiation (LTP) deficits, hippocampal inflammatory cytokines, and neuronal loss in male rats. Rats were randomly divided into four groups as follows: (1) Vehicle; (2) cur; (3) LPS; and (4) cur/LPS...
January 26, 2023: Metabolic Brain Disease
https://read.qxmd.com/read/36692684/modulatory-role-of-curcumin-on-cobalt-induced-memory-deficit-hippocampal-oxidative-damage-astrocytosis-and-nrf2-expression
#39
JOURNAL ARTICLE
Rademene S Oria, Godson E Anyanwu, Emmanuel A Esom, Johnson N Nto, Amechi U Katchy, Augustine U Agu, Omamuyovwi M Ijomone
Chemical overexposure is a growing environmental risk factor for many medical issues. Cobalt toxicity from environmental, industrial, and medical exposure has previously been linked to neurological impairment. Hence, the current study looked into the neuroprotective potential of curcumin, a natural polyphenol contained in the spice turmeric, against cobalt-induced neurotoxicity. Adult rats were randomly divided into six groups as follows: control, 40 mg/kg cobalt chloride (CoCl2 ) only, 240 mg/kg curcumin only, 120 mg/kg or 240 mg/kg curcumin, or 100 mg/kg vitamin C co-administered with CoCl2 ...
January 24, 2023: Neurotoxicity Research
https://read.qxmd.com/read/36579430/role-of-multi-targeted-bioactive-natural-molecules-and-their-derivatives-in-the-treatment-of-alzheimer-s-disease-an-insight-into-structure-activity-relationship
#40
REVIEW
Debojyoti Halder, Subham Das, Jeyaprakash R S, Alex Joseph
Alzheimer's disease (AD) is a complex neurodegenerative disorder involving cognitive dysfunction like short-term memory and behavioral changes as the disease progresses due to other unaltered physiological factors. The solution for this problem is Multi-targeted Drugs (MTDs), which can affect multiple determinants to realize the multifunctional effects. Acetylcholinesterase (AChE) inhibitors donepezil, rivastigmine, galantamine, and N-methyl-D-aspartate (NMDA) receptor antagonist memantine are FDA-approved drugs used to treat AD symptomatically...
December 29, 2022: Journal of Biomolecular Structure & Dynamics
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