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https://www.readbyqxmd.com/read/29723552/pi3k-akt-gsk3%C3%AE-induced-creb-activation-ameliorates-arsenic-mediated-alterations-in-nmda-receptors-and-associated-signaling-in-rat-hippocampus-neuroprotective-role-of-curcumin
#1
Pranay Srivastava, Yogesh K Dhuriya, Vivek Kumar, Akriti Srivastava, Richa Gupta, Rajendra K Shukla, Rajesh S Yadav, Hari N Dwivedi, Aditya B Pant, Vinay K Khanna
Protective efficacy of curcumin in arsenic induced NMDA receptor dysfunctions and PI3 K/Akt/ GSK3β signalling in hippocampus has been investigated in vivo and in vitro. Exposure to sodium arsenite (in vivo - 20 mg/kg, body weight p.o. for 28 days; in vitro - 10 µM for 24 hrs) and curcumin (in vivo - 100 mg/kg body weight p.o. for 28 days; in vitro - 20 µM for 24 hrs) was carried out alone or simultaneously. Treatment with curcumin ameliorated sodium arsenite induced alterations in the levels of NMDA receptors, its receptor subunits and synaptic proteins - pCaMKIIα, PSD-95 and SynGAP both in vivo and in vitro...
April 30, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29704550/tau-hyperphosphorylation-and-p-creb-reduction-are-involved-in-acrylamide-induced-spatial-memory-impairment-suppression-by-curcumin
#2
Dandan Yan, Jianling Yao, Ying Liu, Xing Zhang, Yiqi Wang, Xiaoyi Chen, Liegang Liu, Nian Shi, Hong Yan
Acrylamide (ACR) is an axonal toxicant that produces peripheral neuropathy in laboratory animals and humans. Epidemiological study found that diet ACR exposure was associated with a mild cognitive decline in men. However, limited information is available as regards its potential and underlying mechanism to cause memory alterations. Curcumin is a polyphenol with neuroprotective and cognitive-enhancing properties. In this study, we aimed to investigate the mechanism of ACR-induced spatial memory impairment and the beneficial effect of curcumin...
April 26, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29667473/harnessing-neuroplasticity-modern-approaches-and-clinical-future
#3
Andrew Octavian Sasmita, Joshua Kuruvilla, Anna Pick Kiong Ling
Neurological diseases and injuries to the nervous system may cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would catastrophically accumulate, leading to the development of neurological and neurodegenerative disorders which might affect memory, cognition, and motoric functions. The body has various negative feedback systems which are able to induce beneficial neuroplastic changes in mediating some neuronal damage, however, such efforts are often not enough to ameliorate the derogatory changes...
April 18, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29659685/can-curcumin-counteract-cognitive-decline-clinical-trial-evidence-and-rationale-for-combining-%C3%AF-3-fatty-acids-with-curcumin
#4
Julia Christina Kuszewski, Rachel Heloise Xiwen Wong, Peter Ranald Charles Howe
The rate of cognitive decline in the elderly is highly variable. One potential factor contributing to accelerated cognitive decline is chronic systemic inflammation, because it has been linked to cognitive impairment and increased dementia risk. Certain lifestyle factors, such as excess body weight and sedentary behavior, can exacerbate a proinflammatory state in older adults, resulting in chronic low-grade inflammation. Supplementing the diet with curcumin, an anti-inflammatory polyphenolic compound from the curry spice turmeric, is a potential approach to prevent accelerated cognitive decline by counteracting chronic inflammatory processes...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29626566/the-antidepressant-like-effects-of-a-novel-curcumin-derivative-j147-involvement-of-5-ht-1a-receptor
#5
Lejing Lian, Ying Xu, Jianbo Zhang, Yingcong Yu, Naping Zhu, Xiaofei Guan, Hui Huang, Ruijie Chen, Jie Chen, Guilan Shi, Jianchun Pan
Depression is a dysthymia disorder characterized by a pervasive or persistent mental disorder that causes mood, cognitive and memory deficits. J147, a curcumin analogue, increases brain derived neurotrophic factor (BDNF) levels and facilitates memory in animals. Because curcumin has the antidepressant-like activity, the present study investigated the potential antidepressant-like effects of J147 in the forced swimming test (FST) and tail suspension tests (TST) and the involvement of 5-HT receptors related to cAMP signaling...
April 4, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29607689/curcumin-and-resveratrol-rescue-cortical-hippocampal-system-from-chronic-fluoride-induced-neurodegeneration-and-enhance-memory-retrieval
#6
Chhavi Sharma, Pooja Suhalka, Maheep Bhatnagar
OBJECTIVE: The aim of this study were: (1) To evaluate neuroprotective effect of Resveratrol and Curcumin on NADPH-d (Nicotinamide adenine dinucleotide phosphate diaphorase) activity in neuronal cell in sub regions of mice brain (2) To evaluate the effects on antioxidant status, and (3) To evaluate the protective effects of phytochemicals on learning and memory following fluoride exposure. METHOD: Young Mice (one month old, B.W. 30±5mg) were provided to 120 ppm sodium fluoride dissolved in drinking water...
April 2, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29556196/curcumin-prevents-acute-neuroinflammation-and-long-term-memory-impairment-induced-by-systemic-lipopolysaccharide-in-mice
#7
Vincenzo Sorrenti, Gabriella Contarini, Stefania Sut, Stefano Dall'Acqua, Francesca Confortin, Andrea Pagetta, Pietro Giusti, Morena Zusso
Systemic lipopolysaccharide (LPS) induces an acute inflammatory response in the central nervous system (CNS) ("neuroinflammation") characterized by altered functions of microglial cells, the major resident immune cells of the CNS, and an increased inflammatory profile that can result in long-term neuronal cell damage and severe behavioral and cognitive consequences. Curcumin, a natural compound, exerts CNS anti-inflammatory and neuroprotective functions mainly after chronic treatment. However, its effect after acute treatment has not been well investigated...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29454881/curcumin-treatment-leads-to-better-cognitive-and-mood-function-in-a-model-of-gulf-war-illness-with-enhanced-neurogenesis-and-alleviation-of-inflammation-and-mitochondrial-dysfunction-in-the-hippocampus
#8
M Kodali, B Hattiangady, G A Shetty, A Bates, B Shuai, A K Shetty
Diminished cognitive and mood function are among the most conspicuous symptoms of Gulf War Illness (GWI). Our previous studies in a rat model of GWI have demonstrated that persistent cognitive and mood impairments are associated with substantially declined neurogenesis, chronic low-grade inflammation, increased oxidative stress and mitochondrial dysfunction in the hippocampus. We tested the efficacy of curcumin (CUR) to maintain better cognitive and mood function in a rat model of GWI because of its neurogenic, antiinflammatory, antioxidant, and memory and mood enhancing properties...
March 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29332042/protective-effects-of-indian-spice-curcumin-against-amyloid-%C3%AE-in-alzheimer-s-disease
#9
P Hemachandra Reddy, Maria Manczak, Xiangling Yin, Mary Catherine Grady, Andrew Mitchell, Sahil Tonk, Chandra Sekhar Kuruva, Jasvinder Singh Bhatti, Ramesh Kandimalla, Murali Vijayan, Subodh Kumar, Rui Wang, Jangampalli Adi Pradeepkiran, Gilbert Ogunmokun, Kavya Thamarai, Kandi Quesada, Annette Boles, Arubala P Reddy
The purpose of our article is to assess the current understanding of Indian spice, curcumin, against amyloid-β (Aβ)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural products, such as ginger, curcumin, and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes, and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, antioxidant, anti-arthritis, pro-healing, and boosting memory cognitive functions...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29287782/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic-neurotransmission-and-consolidates-memory-in-male-rats
#10
Laraib Liaquat, Zehra Batool, Sadia Sadir, Sahar Rafiq, Sidrah Shahzad, Tahira Perveen, Saida Haider
AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress...
February 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29246725/memory-and-brain-amyloid-and-tau-effects-of-a-bioavailable-form-of-curcumin-in-non-demented-adults-a-double-blind-placebo-controlled-18-month-trial
#11
Gary W Small, Prabha Siddarth, Zhaoping Li, Karen J Miller, Linda Ercoli, Natacha D Emerson, Jacqueline Martinez, Koon-Pong Wong, Jie Liu, David A Merrill, Stephen T Chen, Susanne M Henning, Nagichettiar Satyamurthy, Sung-Cheng Huang, David Heber, Jorge R Barrio
OBJECTIVE: Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration, we studied its effect on memory in non-demented adults and explored its impact on brain amyloid and tau accumulation using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile positron emission tomography (FDDNP-PET). METHODS: Forty subjects (age 51-84 years) were randomized to a bioavailable form of curcumin (Theracurmin® containing 90 mg of curcumin twice daily [N = 21]) or placebo (N = 19) for 18 months...
March 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29221948/cnb-001-a-synthetic-pyrazole-derivative-of-curcumin-suppresses-lipopolysaccharide-induced-nitric-oxide-production-through-the-inhibition-of-nf-%C3%AE%C2%BAb-and-p38-mapk-pathways-in-microglia
#12
Tatsuhiro Akaishi, Kazuho Abe
CNB-001, a pyrazole derivative of curcumin, has been found to exert neuroprotective and memory-enhancing effects that may be effective for the treatment of Alzheimer's disease. Since aberrant activation of microglia is involved in the pathogenesis of Alzheimer's disease, the present study was undertaken to investigate the effect of CNB-001 on microglia-mediated inflammatory responses. In primary cultured rat microglia, CNB-001 (1-10µM) suppressed the lipopolysaccharide (LPS)-induced nitric oxide (NO) production and expression of inducible NO synthase (iNOS), and the potency of CNB-001 was stronger than curcumin...
January 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29113362/plga-nanoparticles-modified-with-a-bbb-penetrating-peptide-co-delivering-a%C3%AE-generation-inhibitor-and-curcumin-attenuate-memory-deficits-and-neuropathology-in-alzheimer-s-disease-mice
#13
Na Huang, Shuai Lu, Xiao-Ge Liu, Jie Zhu, Yu-Jiong Wang, Rui-Tian Liu
Alzheimer's disease (AD) is the most common form of dementia, characterized by the formation of extracellular senile plaques and neuronal loss caused by amyloid β (Aβ) aggregates in the brains of AD patients. Conventional strategies failed to treat AD in clinical trials, partly due to the poor solubility, low bioavailability and ineffectiveness of the tested drugs to cross the blood-brain barrier (BBB). Moreover, AD is a complex, multifactorial neurodegenerative disease; one-target strategies may be insufficient to prevent the processes of AD...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098059/curcumin-reverses-the-diazepam-induced-cognitive-impairment-by-modulation-of-oxidative-stress-and-erk-1-2-nf-%C3%AE%C2%BAb-pathway-in-brain
#14
Alexandra C Sevastre-Berghian, Vlad Făgărăsan, Vlad A Toma, Ioana Bâldea, Diana Olteanu, Remus Moldovan, Nicoleta Decea, Gabriela A Filip, Simona V Clichici
Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was to evaluate the effects of curcumin (CUR) on spatial cognition, ambulatory activity, and blood and brain oxidative stress levels. The ERK/NF-κB signaling pathway and the histopathological changes in the hippocampus and frontal lobe, in diazepam-treated rats, were also analyzed. The animals were divided into 4 groups: control, carboxymethylcellulose (CMC) + CUR, CMC + DZP, and CUR + CMC + DZP...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29062301/curcumin-exerts-effects-on-the-pathophysiology-of-alzheimer-s-disease-by-regulating-pi-3-5-p2-and-transient-receptor-potential-mucolipin-1-expression
#15
Lu Zhang, Yu Fang, Xuan Cheng, Ya-Jun Lian, Hong-Liang Xu, Zhao-Shu Zeng, Hong-Can Zhu
BACKGROUND: To validate our speculation that curcumin may ameliorate Alzheimer's disease (AD) pathogenesis by regulating PI(3,5)P2 and transient receptor potential mucolipin-1 (TRPML1) expression levels. METHODS: We developed an animal model presenting AD by APP/PS1 transgenes. The mouse clonal hippocampal neuronal cell line HT-22 was treated with amyloid-β1-42 (Aβ1-42). Curcumin was administrated both in vivo and in vitro . MTS assay was used to detect cell viability, and the lysosomal [Ca2+ ] ion concentration was detected...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29047012/chronic-curcumin-treatment-improves-spatial-working-memory-but-not-recognition-memory-in-middle-aged-rhesus-monkeys
#16
Tara L Moore, Bethany Bowley, Penny Shultz, Samantha Calderazzo, Eli Shobin, Ronald J Killiany, Douglas L Rosene, Mark B Moss
Studies of both humans and non-human primates have demonstrated that aging is typically characterized by a decline in cognition that can occur as early as the fifth decade of life. Age-related changes in working memory are particularly evident and mediated, in part, by the prefrontal cortex, an area known to evidence age-related changes in myelin that is attributed to inflammation. In recent years, several nutraceuticals, including curcumin, by virtue of their anti-inflammatory and antioxidant effects, have received considerable attention as potential treatments for age-related cognitive decline and inflammation...
December 2017: GeroScience
https://www.readbyqxmd.com/read/29036814/curcumin-ameliorates-neuroinflammation-neurodegeneration-and-memory-deficits-in-p25-transgenic-mouse-model-that-bears-hallmarks-of-alzheimer-s-disease
#17
Jeyapriya Raja Sundaram, Charlene Priscilla Poore, Noor Hazim Bin Sulaimee, Tej Pareek, Wei Fun Cheong, Markus R Wenk, Harish C Pant, Sally A Frautschy, Chian-Ming Low, Sashi Kesavapany
Several studies have indicated that neuroinflammation is indeed associated with neurodegenerative disease pathology. However, failures of recent clinical trials of anti-inflammatory agents in neurodegenerative disorders have emphasized the need to better understand the complexity of the neuroinflammatory process in order to unravel its link with neurodegeneration. Deregulation of Cyclin-dependent kinase 5 (Cdk5) activity by production of its hyperactivator p25 is involved in the formation of tau and amyloid pathology reminiscent of Alzheimer's disease (AD)...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28931469/restorative-effects-of-curcumin-on-sleep-deprivation-induced-memory-impairments-and-structural-changes-of-the-hippocampus-in-a-rat-model
#18
Ali Noorafshan, Fatemeh Karimi, Ali-Mohammad Kamali, Saied Karbalay-Doust, Mohammad Nami
The present study examined the consequences of rapid eye-movement sleep-deprivation (REM-SD) with or without curcumin treatment. The outcome measures comprised quantitative features in the three-dimensional reconstruction (3DR) CA1 and dentate gyrus in experimental and control animals using stereological procedures. Male rats were arbitrarily assigned to nine groups based on the intervention and treatment administered including: 1-cage control+distilled water, 2-cage control+curcumin (100mg/kg/day), 3-cage control+olive oil, 4-REM-SD+distilled water, 5-REM-SD+curcumin, 6-REM-SD+olive oil, 7-grid-floor control+distilled water, 8-grid-floor control+curcumin, and 9-grid-floor control+olive oil...
November 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28868124/neuroprotective-role-of-curcumin-on-the-hippocampus-against-the-structural-and-serological-alterations-of-streptozotocin-induced-diabetes-in-sprague-dawely-rats
#19
Nermeen Mohammed Faheem, Ahmad El Askary
OBJECTIVES: Diabetes mellitus causes impaired memory and cognitive functions. The hippocampus plays a key role in memory and learning. Curcumin attenuates diabetic nephropathy in vivo. Curcumin has shown a neurogenic effect and cognition-enhancing potential in aged rats. The aim of this study is to evaluate the possible protective role of curcumin on the histological and serological changes of the hippocampus in diabetic rats. MATERIALS AND METHODS: Forty albino rats were divided into four groups, ten rats each...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28801114/effects-of-curcumin-on-short-term-spatial-and-recognition-memory-adult-neurogenesis-and-neuroinflammation-in-a-streptozotocin-induced-rat-model-of-dementia-of-alzheimer-s-type
#20
Taysa B Bassani, Joelle M Turnes, Eric L R Moura, Jéssica M Bonato, Valentín Cóppola-Segovia, Silvio M Zanata, Rúbia M M W Oliveira, Maria A B F Vital
Curcumin is a natural polyphenol with evidence of antioxidant, anti-inflammatory and neuroprotective properties. Recent evidence also suggests that curcumin increases cognitive performance in animal models of dementia, and this effect would be related to its capacity to enhance adult neurogenesis. The aim of this study was to test the hypothesis that curcumin treatment would be able to preserve cognition by increasing neurogenesis and decreasing neuroinflammation in the model of dementia of Alzheimer's type induced by an intracerebroventricular injection of streptozotocin (ICV-STZ) in Wistar rats...
August 8, 2017: Behavioural Brain Research
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