Natalya M Kogan, Dilorom Begmatova, Liudmila Vinnikova, Sergey Malitsky, Maxim Itkin, Eyal Sharon, Artem Klinov, Jonathan Gorelick, Igor Koman, Zvi Vogel, Raphael Mechoulam, Albert Pinhasov
Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the endocannabinoid profile in the brains of mice with strong characteristics of social dominance and submissiveness. Methods: A lipidomics approach was employed to assess the endocannabinoidome in the brains of Dominant (Dom) and Submissive (Sub) mice. The endocannabinoid showing the greatest difference in concentration in the brain between the groups, docosatetraenoyl ethanolamine (DEA), was synthesized, and its effects on the physiological and behavioral responses of Dom and Sub mice were evaluated...
2023: Frontiers in Pharmacology