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https://www.readbyqxmd.com/read/28489322/developmental-effects-of-androgens-in-the-human-brain
#1
REVIEW
Tuong-Vi Nguyen
Neuroendocrine theories of brain development posit that androgens play a crucial role in sex-specific cortical growth, but little is known about the differential effects of testosterone and dehydroepiandrosterone (DHEA) on cortico-limbic development and cognition during adolescence. In this context, the NIH Study of Normal Brain Development, a longitudinal study of typically developing children and adolescents 4 to 24 years of age (n=433), offered a unique opportunity to examine the developmental effects of androgens on cortico-limbic maturation and cognition...
May 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28400246/the-effects-of-captivity-survival-training-on-mood-dissociation-ptsd-symptoms-cognitive-performance-and-stress-hormones
#2
Cindy Suurd Ralph, Oshin Vartanian, Harris R Lieberman, Charles A Morgan, Bob Cheung
In the Canadian Armed Forces (CAF), Conduct After Capture (CAC) training is a 4-day captivity survival course during which soldiers are exposed to increasing stress, and evaluated on their ability to accomplish military objectives. We hypothesized that: (a) compared to baseline, CAC training would cause significant, reversible perturbations in measures of psychological functioning and serum and salivary stress hormone levels relevant to models of stress hardiness and vulnerability; and (b) deviations from baseline would be maximal at the time point of most intense stress during training...
April 8, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28274826/the-novel-dehydroepiandrosterone-dhea-derivative-bnn27-counteracts-delay-dependent-and-scopolamine-induced-recognition-memory-deficitsm-in-rats
#3
Nikolaos Pitsikas, Achille Gravanis
Experimental evidence indicates that the neurosteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are involved in cognition. BNN27 is a novel 17C spiroepoxy-DHEA derivative, which devoid of steroidogenic activity. The neuroprotective effects of BNN27 have been recently reported. The present study was designed to investigate the effects of BNN27 on recognition memory in rats. For this purpose, the novel object task (NOT), a procedure assessing non-spatial recognition memory and the novel location task (NLT), a procedure evaluating spatial recognition memory were used...
March 6, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28178640/a-phase-i-ii-study-of-the-investigational-drug-alisertib-in-combination-with-abiraterone-and-prednisone-for-patients-with-metastatic-castration-resistant-prostate-cancer-progressing-on-abiraterone
#4
Jianqing Lin, Sheel A Patel, Ashwin R Sama, Jean H Hoffman-Censits, Brooke Kennedy, Deborah Kilpatrick, Zhong Ye, Hushan Yang, Zhaomei Mu, Benjamin Leiby, Nancy Lewis, Massimo Cristofanilli, William Kevin Kelly
LESSONS LEARNED: Patients with metastatic castration-resistant prostate cancer did not tolerate the combination of alisertib with abiraterone and prednisone.There was no clear signal indicating that adding alisertib might be beneficial for those patients progressing on abiraterone. BACKGROUND: We hypothesized that Aurora A kinase (AK) contributes to castrate resistance in prostate cancer (PCa) and that inhibiting AK with alisertib can resensitize PCa cells to androgen receptor (AR) inhibitor abiraterone...
November 2016: Oncologist
https://www.readbyqxmd.com/read/27984812/sex-specific-associations-of-testosterone-with-prefrontal-hippocampal-development-and-executive-function
#5
Tuong-Vi Nguyen, Jimin Lew, Matthew D Albaugh, Kelly N Botteron, James J Hudziak, Vladimir S Fonov, D Louis Collins, Simon Ducharme, James T McCracken
Testosterone is thought to play a crucial role in mediating sexual differentiation of brain structures. Examinations of the cognitive effects of testosterone have also shown beneficial and potentially sex-specific effects on executive function and mnemonic processes. Yet these findings remain limited by an incomplete understanding of the critical timing and brain regions most affected by testosterone, the lack of documented links between testosterone-related structural brain changes and cognition, and the difficulty in distinguishing the effects of testosterone from those of related sex steroids such as of estradiol and dehydroepiandrosterone (DHEA)...
February 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27776205/investigations-on-16-arylideno-steroids-as-a-new-class-of-neuroprotective-agents-for-the-treatment-of-alzheimer-s-and-parkinson-s-diseases
#6
Ranjit Singh, Ranju Bansal
Neuroinflammatory mechanisms mediated by activated glial and cytokines (TNF-α, IL-1β) might contribute to neuronal degeneration leading to Alzheimer's (AD) and Parkinson's disease (PD). Lipopolysaccharide (LPS) is an inflammogen derived from the cell wall of Gram-negative bacteria, which promotes neuroinflammation and subsequent neurodegeneration. Dehydroepiandrosterone (DHEA) and testosterone have been reported as neuroprotective steroids useful for the treatment of various neurodegenerative disorders. In the present study, several 16-arylidene steroidal derivatives have been evaluated as neuroprotective agents in LPS-treated animal models...
January 18, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27736018/cognition-in-aged-rhesus-monkeys-effect-of-dhea-and-correlation-with-steroidogenic-gene-expression
#7
K G Sorwell, L Renner, A R Weiss, M Neuringer, S G Kohama, H F Urbanski
Estradiol supplementation has been shown to enhance cognitive performance in old ovariectomized rhesus macaques (Macaca mulatta). To determine if similar benefits could be achieved in perimenopausal animals using alternative hormonal supplements, we administered dehydroepiandrosterone (DHEA) to old ovary-intact female rhesus macaques for ∼2.5 months. Using computerized touch screen memory tasks, including delayed response (DR) and delayed matching-to-sample (DMS), we observed improved performance with time in all of the animals but failed to detect a significant effect of DHEA...
March 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27717832/hormonal-modulation-of-novelty-processing-in-women-enhanced-under-working-memory-load-with-high-dehydroepiandrosterone-sulfate-to-dehydroepiandrosterone-ratios
#8
Sónia do Vale, Lenka Selinger, João Martin Martins, Manuel Bicho, Isabel do Carmo, Carles Escera
Several studies have suggested that dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) may enhance working memory and attention, yet current evidence is still inconclusive. The balance between both forms of the hormone might be crucial regarding the effects that DHEA and DHEAS exert on the central nervous system. To test the hypothesis that higher DHEAS-to-DHEA ratios might enhance working memory and/or involuntary attention, we studied the DHEAS-to-DHEA ratio in relation to involuntary attention and working memory processing by recording the electroencephalogram of 22 young women while performing a working memory load task and a task without working memory load in an audio-visual oddball paradigm...
October 4, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27706235/age-effects-on-cognitive-and-physiological-parameters-in-familial-caregivers-of-alzheimer-s-disease-patients
#9
Márcio Silveira Corrêa, Bruno Lima Giacobbo, Kelem Vedovelli, Daiane Borba de Lima, Pamela Ferrari, Irani Iracema de Lima Argimon, Julio Cesar Walz, Elke Bromberg
OBJECTIVES: Older familial caregivers of Alzheimer's disease patients are subjected to stress-related cognitive and psychophysiological dysfunctions that may affect their quality of life and ability to provide care. Younger caregivers have never been properly evaluated. We hypothesized that they would show qualitatively similar cognitive and psychophysiological alterations to those of older caregivers. METHOD: The cognitive measures of 17 young (31-58 years) and 18 old (63-84 years) caregivers and of 17 young (37-57 years) and 18 old (62-84 years) non-caregiver controls were evaluated together with their salivary cortisol and dehydroepiandrosterone (DHEA) levels, as measured by radioimmunoassays and ELISA assays of brain-derived neurotrophic factor (BDNF) in serum...
2016: PloS One
https://www.readbyqxmd.com/read/27402021/effect-of-hypoxia-on-cerebrovascular-and-cognitive-function-during-moderate-intensity-exercise
#10
Wesley K Lefferts, Matthew C Babcock, Matthew J Tiss, Stephen J Ives, Corey N White, Tom D Brutsaert, Kevin S Heffernan
Exercise in hypoxia places added demands on the brain and cerebrovasculature that can impact cognitive function. The purpose of this study was to investigate the effect of acute hypoxia on cerebrovascular hemodynamics, markers of neuro-steroidal modulation and brain-blood barrier (BBB) integrity, and cognition during exercise. Thirty healthy participants (21±4yrs., BMI 24.0±2.6kg∙m(-2); 15 men) were randomized to both a≈2.5h normoxic (FiO2 20.0%) and hypoxic (FiO2 12.5%) condition on two separate days...
October 15, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27374427/cognitive-function-stress-hormones-heart-rate-and-nutritional-status-during-simulated-captivity-in-military-survival-training
#11
Harris R Lieberman, Emily K Farina, John Caldwell, Kelly W Williams, Lauren A Thompson, Philip J Niro, Kyle A Grohmann, James P McClung
Stress influences numerous psychological and physiological processes, and its effects have practical implications in a variety of professions and real-world activities. However, few studies have concurrently assessed multiple behavioral, hormonal, nutritional and heart-rate responses of humans to acute, severe stress. This investigation simultaneously assessed cognitive, affective, hormonal, and heart-rate responses induced by an intensely stressful real-world environment designed to simulate wartime captivity...
October 15, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27346998/dehydroepiandrosterone-its-sulfate-and-cognitive-functions
#12
Karina Junqueira de Menezes, Clayton Peixoto, Antonio Egidio Nardi, Mauro Giovanni Carta, Sérgio Machado, André Barciela Veras
UNLABELLED: To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition. METHODS: The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A systematic review was proceeded using three databases: PubMed, ISI Web of Science, and PsycINFO...
2016: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/27222435/steroid-sulfatase-inhibitor-du-14-protects-spatial-memory-and-synaptic-plasticity-from-disruption-by-amyloid-%C3%AE-protein-in-male-rats
#13
Xing-Hua Yue, Jia-Qing Tong, Zhao-Jun Wang, Jun Zhang, Xu Liu, Xiao-Jie Liu, Hong-Yan Cai, Jin-Shun Qi
Alzheimer's disease (AD) is an age-related mental disorder characterized by progressive loss of memory and multiple cognitive impairments. The overproduction and aggregation of Amyloid β protein (Aβ) in the brain, especially in the hippocampus, are closely involved in the memory loss in the patients with AD. Accumulating evidence indicates that the Aβ-induced imbalance of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) in the brain plays an important role in the AD pathogenesis and progression...
July 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27051273/effects-of-acute-and-chronic-administration-of-neurosteroid-dehydroepiandrosterone-sulfate-on-neuronal-excitability-in-mice
#14
Dubravka Svob Strac, Josipa Vlainic, Janko Samardzic, Julija Erhardt, Zeljka Krsnik
BACKGROUND: Neurosteroid dehydroepiandrosterone sulfate (DHEAS) has been associated with important brain functions, including neuronal survival, memory, and behavior, showing therapeutic potential in various neuropsychiatric and cognitive disorders. However, the antagonistic effects of DHEAS on γ-amino-butyric acidA receptors and its facilitatory action on glutamatergic neurotransmission might lead to enhanced brain excitability and seizures and thus limit DHEAS therapeutic applications...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26970429/paper-or-plastic-exploring-the-effects-of-natural-enrichment-on-behavioural-and-neuroendocrine-responses-in-long-evans-rats
#15
M Bardi, C Kaufman, C Franssen, M M Hyer, A Rzucidlo, M Brown, M Tschirhart, K G Lambert
Enriched environments are beneficial to neurobiological development; specifically, rodents exposed to complex, rather than standard laboratory, environments exhibit evidence of neuroplasticity and enhanced cognitive performance. In the present study, the nature of elements placed in the complex environment was investigated. Accordingly, rats (n = 8 per group) were housed either in a natural environment characterised by stimuli such as dirt and rocks, an artificial environment characterised by plastic toys and synthetic nesting materials, a natural/artificial environment characterised by a combination of artificial and natural stimuli or a laboratory standard environment characterised by no enrichment stimuli...
May 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/26969211/biological-aspects-and-candidate-biomarkers-for-psychotic-bipolar-disorder-a-systematic-review
#16
REVIEW
Massimiliano Buoli, Alice Caldiroli, Claudia Cumerlato Melter, Marta Serati, Jessica de Nijs, A Carlo Altamura
AIM: We carried out a systematic review of the available literature about potential biomarkers of psychotic bipolar disorder (BD-P), a specific subset presenting worse outcome and greater risk of relapse than non-psychotic bipolar disorder (BD-NP). METHODS: We searched the main psychiatric databases (PubMed, ISI Web of Knowledge, PsychInfo). Only original articles with the main topic of BD-P compared to schizophrenia/BD-NP/healthy controls (HC) written in English from 1994 to 2015 were included...
June 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/26892578/the-independent-role-of-inflammation-in-physical-frailty-among-older-adults-with-mild-cognitive-impairment-and-mild-to-moderate-alzheimer-s-disease
#17
L Tay, W S Lim, M Chan, R J Ye, M S Chong
OBJECTIVES: To examine the independent and combined effects of inflammation and endocrine dysregulation on (i) baseline frailty status and (ii) frailty progression at one year, among cognitively impaired community dwelling older adults. DESIGN: Prospective cohort study. SETTING: Tertiary Memory Clinic. METHODS: We recruited patients with mild cognitive impairment and mild-moderate Alzheimer's disease. Physical frailty status was assessed at baseline and 1-year...
March 2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/26806389/endogenous-sex-hormones-and-cognitive-function-in-older-women
#18
Alain K Koyama, Shelley S Tworoger, A Heather Eliassen, Olivia I Okereke, Marc G Weisskopf, Bernard Rosner, Kristine Yaffe, Francine Grodstein
INTRODUCTION: We examined the association between endogenous sex hormones and both objective and subjective measures of cognitive function. METHODS: We followed 3044 women up to 23 years in a prospective cohort study. We measured plasma levels of estrone, estrone sulfate, estradiol, androstenedione, testosterone, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S) in 1989-1990, conducted neuropsychologic testing in 1999-2008, and inquired about subjective cognition in 2012...
July 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/26746105/depression-as-a-risk-factor-for-alzheimer-s-disease-genes-steroids-cytokines-and-neurogenesis-what-do-we-need-to-know
#19
Joe Herbert, Paul J Lucassen
Depression (MDD) is prodromal to, and a component of, Alzheimer's disease (AD): it may also be a trigger for incipient AD. MDD is not a unitary disorder, so there may be particular subtypes of early life MDD that pose independent high risks for later AD, though the identification of these subtypes is problematical. There may either be a common pathological event underlying both MDD and AD, or MDD may sensitize the brain to a second event ('hit') that precipitates AD. MDD may also accelerate brain ageing, including altered DNA methylation, increased cortisol but decreasing DHEA and thus the risk for AD...
April 2016: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/26409015/testicular-function-in-a-birth-cohort-of-young-men
#20
R J Hart, D A Doherty, R I McLachlan, M L Walls, J A Keelan, J E Dickinson, N E Skakkebaek, R J Norman, D J Handelsman
STUDY QUESTION: By investigating a birth cohort with a high ongoing participation rate to derive an unbiased population, what are the parameters and influences upon testicular function for a population not selected with regard to fertility? SUMMARY ANSWER: While varicocele, cryptorchidism and obesity may impact on human testicular function, most common drug exposures and the presence of epididymal cysts appear to have no or minimal adverse impact. WHAT IS KNOWN ALREADY: The majority of previous attempts to develop valid reference populations for spermatogenesis have relied on potentially biased sources such as recruits from infertility clinics, self-selected volunteer sperm donors for research or artificial insemination or once-fertile men seeking vasectomy...
December 2015: Human Reproduction
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