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In this study, we examined whether orthographic learning can be demonstrated in disabled readers learning to read in a transparent orthography (Dutch). In addition, we tested the effect of the use of text-to-speech software, a new form of direct instruction, on orthographic learning. Both research goals were investigated by replicating Share's self-teaching paradigm. A total of 65 disabled Dutch readers were asked to read eight stories containing embedded homophonic pseudoword targets (e.g., Blot/Blod), with or without the support of text-to-speech software...

Anti-hr(B) (-RH31) and anti-Hr(B) (-RH34) were found nearly 40 years ago in the serum of a South African woman. The anti-hr(B) was revealed after adsorption with DcE/DcE red blod cells (RCBs). Numerous anti-hr(B), in the absence of anti-Hr(B), have since been identified. We obtained a sample of blood from this index case (Bastiaan) and report the molecular basis of her D+C-E-c+e+/-, V-VS+Hr+hr(S)+hr(B)-Hr(B)- phenotype as well as results of testing her RBCs using currently available regents. We tested a cohort of African Americans to estimate the frequency of the RHCE*ce 48C,733G,1006T allele, and in addition found two novel RHD alleles...

BACKGROUND: It has been suggested that red blood cell transfusions may affect the outcome and frequency of infection in patients treated in ITU settings. We have therefore retrospectively analysed the records of one hundred and sixty-three patients treated in a large tertiary intensive care unit, in order to find any relationship between red blod cell transfusions and the frequency of nosocomial infections. METHODS: The patients were allocated to two groups: T - those who were transfused and N - those who were not...

Using simultaneous EEG-correlated functional MRI (EEG-fMRI), we studied the blood oxygenation level-dependent (BOLD) signals in a juvenile myoclonic epilepsy (JME) patient with interictal epileptiform discharges. Extensive and symmetric activation and deactivation areas were assessed in bilateral hemispheric regions respectively, and these signals decreased gradually from the parieto-occipital region to the frontal region. Activations were found in cuneus, insulae, mesial midfrontal region, midline and bilateral cerebellum and thalamus, while the deactivities were in the bilateral anterior frontal region and parietal region as well as the posterior cingulate gyri...

INTRODUCTION: This study aimed to investigate the mechanism of action of acetonic and hexanic extracts of the leaves of Vernonia colorata on blood glucose regulation. MATERIALS AND METHODS: Experiments were performed in normoglycaemic, type 1 and 2 diabetic rats. The effects of acetonic and hexanic extracts on blood glucose were evaluated. The antagonism effect of hexanic extract on the decrease of blood glucose induced with glibenclamide and metformin was also tested...

Proteinase 3 (PR3) is a pleiotropic and destructive serine protease and it is also a major target for autoantibodies in systemic small vessel vasculitis. We have shown recently that patients in stable remission have increased circulating levels of PR3, independent of autoantibody titre, inflammation, neutrophil degranulation and renal function. Here we explore the possibility of increased PR3 gene transcription. RNA was purified from peripheral blood monocytes from vasculitis patients and controls. Specific mRNA was measured by TaqMan real-time polymerase chain reaction (PCR)...

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