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Sara Schülin, Nadine Schlichting, Carlotta Blod, Sabine Opitz, Anne Suttkus, Catalina Suzana Stingu, Kathryn Barry, Martin Lacher, Ulf Bühligen, Steffi Mayer
Intestinal microbiota is involved in metabolic processes and the pathophysiology of various gastrointestinal disorders. We aimed to characterize the microbiome of the appendix in acute pediatric appendicitis comparing extraluminal and intraluminal samples.Between January and June 2015, 29 children (3-17 years, mean age 10.7 ± 3.4 years, sex M:F = 2.6:1) undergoing laparoscopic appendectomy for acute appendicitis were prospectively included in the study. Samples for bacterial cultures (n = 29) and 16S ribosomal desoxyribonucleic acid (rDNA) sequencing (randomly chosen n = 16/29) were taken intracorporeally from the appendiceal surface before preparation ("extraluminal") and from the appendiceal lumen after removal ("intraluminal")...
December 2017: Medicine (Baltimore)
Hatem Abu Hashim, Osama Foda, Mohamed El Rakhawy
PURPOSE: This systematic review and meta-analysis aimed to compare the effectiveness of unilateral vs. bilateral laparoscopic ovarian drilling (ULOD vs. BLOD) for improving fertility outcomes in infertile women with clomiphene-resistant polycystic ovary syndrome (PCOS) as well as its effect on ovarian reserve. METHODS: Searches were conducted on PubMed, ScienceDirect,, and CENTRAL databases from January 1984 to January 2017. Only randomized trials comparing ULOD with BLOD were included...
April 2018: Archives of Gynecology and Obstetrics
Carlotta Blod, Nadine Schlichting, Sara Schülin, Anne Suttkus, Nicole Peukert, Catalina Suzana Stingu, Christian Hirsch, Wieland Elger, Martin Lacher, Ulf Bühligen, Steffi Mayer
PURPOSE: The oral microbiome has been related to numerous extra oral diseases. Recent studies detected a high abundance of oral bacteria in inflamed appendices in pediatric patients. To elucidate the role of oral bacteria in acute pediatric appendicitis, we studied the oral and appendiceal microbiome of affected children compared to healthy controls. METHODS: Between January and June 2015, 21 children undergoing appendectomy for acute appendicitis and 28 healthy controls were prospectively enrolled in the study...
February 2018: International Journal of Colorectal Disease
Yiping Yu, Lanlan Fang, Ruizhe Zhang, Jingyan He, Yujing Xiong, Xiaoyi Guo, Qingyun Du, Yan Huang, Yingpu Sun
The comparative efficacies of ovulation-induction treatments in patients with clomiphene citrate-resistant (CCR) polycystic ovary syndrome (PCOS) are not well known. Therefore, we conducted a network meta-analysis to rank the reproductive efficacies of these treatments. We ultimately included 26 randomized clinical trials with 2722 participants and 9 types of therapies: clomiphene citrate (CC), metformin, letrozole, follicle stimulating hormone (FSH), human menopausal gonadotropin (hMG), unilateral laparoscopic ovarian drilling (ULOD), bilateral laparoscopic ovarian drilling (BLOD), the combination of metformin with letrozole (metformin+letrozole), and the combination of metformin with CC (metformin+CC)...
June 19, 2017: Scientific Reports
Katharina Laubner, Jochen Seufert
SGLT2 inhibitors represent a novel therapeutic approach for the tretment of type 2 diabetes mellitus. Beyond glucose control, these drugs also induce weight loss and blod pressure reduction. In a specific cardiovascular outcome trial (EMPA-REG-OUTCOME), the SGLT 2 inhibitor empagliflozin has for the first time demonstrated to reduce cardiovascular and overall mortality as well as hospitalization for heart failure in patients with type 2 diabetes and high cardiovascular risk. These results will drastically affect future recommendations for the treatment of type 2 diabetes mellitus...
June 2016: Deutsche Medizinische Wochenschrift
Tomislav Jukić, Michael Bruce Zimmermann, Roko Granić, Marin Prpić, Drazena Krilić, Vesna Juresa, Marijan Katalenić, Zvonko Kusić
Current methods for assessment of iodine intake in a population comprise measurements of urinary iodine concentration (UIC), thyroid volume by ultrasound (US-Tvol), and newborn TSH. Serum or dried blood spot thyroglobulin (DBS-Tg) is a new promising functional iodine status biomarker in children. In 1996, a new act on universal salt iodination was introduced in Croatia with 25 mg of potassium iodideper kg of salt. In 2002, Croatia finally reached iodine sufficiency. However, in 2009, median UIC in 101 schoolchildren from Zagreb, the capital of Croatia, was 288 µg/L, posing to be excessive...
December 2015: Acta Clinica Croatica
Seyran Bozkurt, Ataman Köse, Semra Erdogan, Gulten Iraoöz Bozali, Cüneyt Ayrik, Rabia Bozdogan Arpaci, Anil Özgur, Güllü Akbaydogan Dündar, Özgür Turkmenoglu
OBJECTIVE: To investigate whether mean platelet volume can be used as an inflammatory marker for the diagnosis of acute appendicitis, and to determine the role, if any, of white blood cell count, C-reactive protein and neutrophil count in this regard. METHODS: The retrospective study was conducted at Mersin University (MEU) Health Research and Application Center, Emergency Department, Mersin, Turkey, and included medical record of patients having gone appendectomy between April 2012 to July 2013...
June 2015: JPMA. the Journal of the Pakistan Medical Association
Ziba Zahiri Sorouri, Seyede Hajar Sharami, Zinab Tahersima, Fatemeh Salamat
BACKGROUND: Laparoscopic ovarian drilling (LOD) is an alternative method to induce ovulation in polycystic ovary syndrome (PCOS) patients with clomiphene citrate (CC) resistant instead of gonadotropins. This study aimed to compare the efficacy of unilateral LOD (ULOD) versus bilateral LOD (BLOD) in CC resistance PCOS patients in terms of ovulation and pregnancy rates. MATERIALS AND METHODS: In a prospective randomized clinical trial study, we included 100 PCOS patients with CC resistance attending to Al-Zahra Hospital in Rasht, Guilan Province, Iran, from June 2011 to July 2012...
April 2015: International Journal of Fertility & Sterility
Martina Sunj, Miro Kasum, Tomislav Canic, Deni Karelovic, Marijan Tandara, Leida Tandara, Ivan Palada
Women with polycystic ovary syndrome seem to have a larger ovarian reserve. However, regardless of a greater reserve, diminished ovarian reserve has been reported after laparoscopic diathermy. The aim of this article was to determine whether the doses adjusted unilateral laparoscopic ovarian drilling with diathermy (ULOD) diminishes ovarian reserve to compare with bilateral laparoscopic ovarian drilling with diathermy (BLOD). Ninety-six women were assigned in two groups. One group underwent ULOD receiving thermal doses (0-840 J per ovary) adjusted to volume one ovary...
November 2014: Gynecological Endocrinology
Abdulrahman Hakami
SESSION TITLE: Infectious Disease Case Reports Posters IIISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Mycobacterium celatum was first described in 1993 and since then , sporadic reports have been published on the isolation of this mycobacterium from immunocomprised pateints. M. celatum is phenotypically similar to M. avium and M. xenopi. M. celatum is a recently described organism. Several reports exist in the literature establishing this organism as a convincing pathogen among Human Immunodeficiency Virus (HIV) seropositive patients...
March 1, 2014: Chest
M Sunj, T Canic, D P Baldani, M Tandara, A Jeroncic, I Palada
STUDY QUESTION: Does unilateral volume-adjusted laparoscopic diathermy increase the chances of ovulation in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Although unilateral laparoscopic ovarian drilling (ULOD) using adjusted thermal doses was more efficient than bilateral laparoscopic ovarian drilling (BLOD) using fixed doses, the chances of ovulation were improved in patients irrespective of the technique used. WHAT IS KNOWN ALREADY: The adjustment of the thermal dose to ovarian volume in BLOD increases ovulation and pregnancy rates compared with fixed-dose treatment, but BLOD causes the formation of adhesions, particularly on the left ovary, and increases the risk of damage to ovarian tissue...
September 2013: Human Reproduction
Eva Staels, Wim Van den Broeck
In this study, we examined whether orthographic learning can be demonstrated in disabled readers learning to read in a transparent orthography (Dutch). In addition, we tested the effect of the use of text-to-speech software, a new form of direct instruction, on orthographic learning. Both research goals were investigated by replicating Share's self-teaching paradigm. A total of 65 disabled Dutch readers were asked to read eight stories containing embedded homophonic pseudoword targets (e.g., Blot/Blod), with or without the support of text-to-speech software...
January 2015: Journal of Learning Disabilities
M E Reid, C H Hipsky, R W Velliquette, C Lomas-Francis, K Larimore, C Olsen
Anti-hr(B) (-RH31) and anti-Hr(B) (-RH34) were found nearly 40 years ago in the serum of a South African woman. The anti-hr(B) was revealed after adsorption with DcE/DcE red blod cells (RCBs). Numerous anti-hr(B), in the absence of anti-Hr(B), have since been identified. We obtained a sample of blood from this index case (Bastiaan) and report the molecular basis of her D+C-E-c+e+/-, V-VS+Hr+hr(S)+hr(B)-Hr(B)- phenotype as well as results of testing her RBCs using currently available regents. We tested a cohort of African Americans to estimate the frequency of the RHCE*ce 48C,733G,1006T allele, and in addition found two novel RHD alleles...
2012: Immunohematology
Jarosław Mamak, Lech Krawczyk
BACKGROUND: It has been suggested that red blood cell transfusions may affect the outcome and frequency of infection in patients treated in ITU settings. We have therefore retrospectively analysed the records of one hundred and sixty-three patients treated in a large tertiary intensive care unit, in order to find any relationship between red blod cell transfusions and the frequency of nosocomial infections. METHODS: The patients were allocated to two groups: T - those who were transfused and N - those who were not...
October 2011: Anestezjologia Intensywna Terapia
Yonghong Liu, Xuhong Yang, Wei Liao, Ling Liu, Bo Yan, Xu Lin, Jing Xi, Hongru Xu, Huafu Cheng, Dong Zhou
Using simultaneous EEG-correlated functional MRI (EEG-fMRI), we studied the blood oxygenation level-dependent (BOLD) signals in a juvenile myoclonic epilepsy (JME) patient with interictal epileptiform discharges. Extensive and symmetric activation and deactivation areas were assessed in bilateral hemispheric regions respectively, and these signals decreased gradually from the parieto-occipital region to the frontal region. Activations were found in cuneus, insulae, mesial midfrontal region, midline and bilateral cerebellum and thalamus, while the deactivities were in the bilateral anterior frontal region and parietal region as well as the posterior cingulate gyri...
August 2007: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
G Y Sy, R B Nongonierma, A Cisse, A M Dieye, A Wele, N F Gadiaga, B Faye
INTRODUCTION: This study aimed to investigate the mechanism of action of acetonic and hexanic extracts of the leaves of Vernonia colorata on blood glucose regulation. MATERIALS AND METHODS: Experiments were performed in normoglycaemic, type 1 and 2 diabetic rats. The effects of acetonic and hexanic extracts on blood glucose were evaluated. The antagonism effect of hexanic extract on the decrease of blood glucose induced with glibenclamide and metformin was also tested...
2006: Dakar Médical
S Ohlsson, T Hellmark, K Pieters, G Sturfelt, J Wieslander, M Segelmark
Proteinase 3 (PR3) is a pleiotropic and destructive serine protease and it is also a major target for autoantibodies in systemic small vessel vasculitis. We have shown recently that patients in stable remission have increased circulating levels of PR3, independent of autoantibody titre, inflammation, neutrophil degranulation and renal function. Here we explore the possibility of increased PR3 gene transcription. RNA was purified from peripheral blood monocytes from vasculitis patients and controls. Specific mRNA was measured by TaqMan real-time polymerase chain reaction (PCR)...
July 2005: Clinical and Experimental Immunology
No abstract text is available yet for this article.
1961: Helvetica Physiologica et Pharmacologica Acta
No abstract text is available yet for this article.
1961: Acta Clinica Belgica
No abstract text is available yet for this article.
1962: Bulletin de la Société de Chimie Biologique
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