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https://www.readbyqxmd.com/read/27535962/analysis-of-the-uterine-epithelial-and-conceptus-transcriptome-and-luminal-fluid-proteome-during-the-peri-implantation-period-of-pregnancy-in-sheep
#1
Kelsey Brooks, Gregory W Burns, Joao G N Moraes, Thomas E Spencer
Available studies support the idea that the uterine epithelia and their secretions have important biological roles in conceptus survival, elongation and implantation in sheep. The present study evaluated the transcriptome of the uterine luminal epithelium (LE), glandular epithelium (GE) and conceptus, and proteome of the uterine luminal fluid (ULF) during the peri-implantation period of pregnancy. Transcriptome (RNA-sequencing) analysis was conducted on LE and GE isolated from uteri of Day 10, 12, 14, 16, and 20 pregnant sheep by laser capture microdissection...
August 17, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27486097/germline-variation-in-inflammation-related-pathways-and-risk-of-barrett-s-oesophagus-and-oesophageal-adenocarcinoma
#2
Matthew F Buas, Qianchuan He, Lisa G Johnson, Lynn Onstad, David M Levine, Aaron P Thrift, Puya Gharahkhani, Claire Palles, Jesper Lagergren, Rebecca C Fitzgerald, Weimin Ye, Carlos Caldas, Nigel C Bird, Nicholas J Shaheen, Leslie Bernstein, Marilie D Gammon, Anna H Wu, Laura J Hardie, Paul D Pharoah, Geoffrey Liu, Prassad Iyer, Douglas A Corley, Harvey A Risch, Wong-Ho Chow, Hans Prenen, Laura Chegwidden, Sharon Love, Stephen Attwood, Paul Moayyedi, David MacDonald, Rebecca Harrison, Peter Watson, Hugh Barr, John deCaestecker, Ian Tomlinson, Janusz Jankowski, David C Whiteman, Stuart MacGregor, Thomas L Vaughan, Margaret M Madeleine
OBJECTIVE: Oesophageal adenocarcinoma (OA) incidence has risen sharply in Western countries over recent decades. Local and systemic inflammation is considered an important contributor to OA pathogenesis. Established risk factors for OA and its precursor, Barrett's oesophagus (BE), include symptomatic reflux, obesity and smoking. The role of inherited genetic susceptibility remains an area of active investigation. Here, we explore whether germline variation related to inflammatory processes influences susceptibility to BE/OA...
August 2, 2016: Gut
https://www.readbyqxmd.com/read/27424321/up-regulation-of-glutathione-related-genes-enzyme-activities-and-transport-proteins-in-human-cervical-cancer-cells-treated-with-doxorubicin
#3
Ewa Drozd, Jolanta Krzysztoń-Russjan, Jadwiga Marczewska, Janina Drozd, Irena Bubko, Magda Bielak, Katarzyna Lubelska, Katarzyna Wiktorska, Zdzisław Chilmonczyk, Elżbieta Anuszewska, Beata Gruber-Bzura
Doxorubicin (DOX), one of the most effective anticancer drugs, acts in a variety of ways including DNA damage, enzyme inhibition and generation of reactive oxygen species. Glutathione (GSH) and glutathione-related enzymes including: glutathione peroxidase (GPX), glutathione reductase (GSR) and glutathione S-transferases (GST) may play a role in adaptive detoxification processes in response to the oxidative stress, thus contributing to drug resistance phenotype. In this study, we investigated effects of DOX treatment on expression and activity of GSH-related enzymes and multidrug resistance-associated proteins in cultured human cervical cancer cells displaying different resistance against this drug (HeLa and KB-V1)...
July 14, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27206673/reprogramming-human-a375-amelanotic-melanoma-cells-by-catalase-overexpression-upregulation-of-antioxidant-genes-correlates-with-regression-of-melanoma-malignancy-and-with-malignant-progression-when-downregulated
#4
Candelaria Bracalente, Irene L Ibañez, Ariel Berenstein, Cintia Notcovich, María B Cerda, Fabio Klamt, Ariel Chernomoretz, Hebe Durán
Reactive oxygen species (ROS) are implicated in tumor transformation. The antioxidant system (AOS) protects cells from ROS damage. However, it is also hijacked by cancers cells to proliferate within the tumor. Thus, identifying proteins altered by redox imbalance in cancer cells is an attractive prognostic and therapeutic tool. Gene expression microarrays in A375 melanoma cells with different ROS levels after overexpressing catalase were performed. Dissimilar phenotypes by differential compensation to hydrogen peroxide scavenging were generated...
July 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27146958/sequence-based-association-analysis-reveals-an-mgst1-eqtl-with-pleiotropic-effects-on-bovine-milk-composition
#5
Mathew D Littlejohn, Kathryn Tiplady, Tania A Fink, Klaus Lehnert, Thomas Lopdell, Thomas Johnson, Christine Couldrey, Mike Keehan, Richard G Sherlock, Chad Harland, Andrew Scott, Russell G Snell, Stephen R Davis, Richard J Spelman
The mammary gland is a prolific lipogenic organ, synthesising copious amounts of triglycerides for secretion into milk. The fat content of milk varies widely both between and within species, and recent independent genome-wide association studies have highlighted a milk fat percentage quantitative trait locus (QTL) of large effect on bovine chromosome 5. Although both EPS8 and MGST1 have been proposed to underlie these signals, the causative status of these genes has not been functionally confirmed. To investigate this QTL in detail, we report genome sequence-based imputation and association mapping in a population of 64,244 taurine cattle...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27134121/temporal-proteomic-profiling-of-chlamydia-trachomatis-infected-hela-229-human-cervical-epithelial-cells
#6
Grace Min Yi Tan, Hui Jing Lim, Tee Cian Yeow, Elaheh Movahed, Chung Yeng Looi, Rishein Gupta, Bernard P Arulanandam, Sazaly Abu Bakar, Negar Shafiei Sabet, Li-Yen Chang, Won Fen Wong
Chlamydia trachomatis is the leading causative agent of bacterial sexually transmitted infections worldwide which can lead to female pelvic inflammatory disease and infertility. A greater understanding of host response during chlamydial infection is essential to design intervention technique to reduce the increasing incidence rate of genital chlamydial infection. In this study, we investigated proteome changes in epithelial cells during C. trachomatis infection by using an isobaric tags for relative and absolute quantitation (iTRAQ) labeling technique coupled with a liquid chromatography-tandem mass spectrometry (LC-MS(3) ) analysis...
May 2016: Proteomics
https://www.readbyqxmd.com/read/27093577/chemical-reactivity-window-determines-prodrug-efficiency-toward-glutathione-transferase-overexpressing-cancer-cells
#7
Marike W van Gisbergen, Marcus Cebula, Jie Zhang, Astrid Ottosson-Wadlund, Ludwig Dubois, Philippe Lambin, Kenneth D Tew, Danyelle M Townsend, Guido R M M Haenen, Marie-José Drittij-Reijnders, Hisao Saneyoshi, Mika Araki, Yuko Shishido, Yoshihiro Ito, Elias S J Arnér, Hiroshi Abe, Ralf Morgenstern, Katarina Johansson
Glutathione transferases (GSTs) are often overexpressed in tumors and frequently correlated to bad prognosis and resistance against a number of different anticancer drugs. To selectively target these cells and to overcome this resistance we previously have developed prodrugs that are derivatives of existing anticancer drugs (e.g., doxorubicin) incorporating a sulfonamide moiety. When cleaved by GSTs, the prodrug releases the cytostatic moiety predominantly in GST overexpressing cells, thus sparing normal cells with moderate enzyme levels...
April 28, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27080405/effect-of-static-magnetic-fields-and-phloretin-on-antioxidant-defense-system-of-human-fibroblasts
#8
Katarzyna Pawłowska-Góral, Magdalena Kimsa-Dudek, Agnieszka Synowiec-Wojtarowicz, Joanna Orchel, Marek Glinka, Stanisław Gawron
The available evidence from in vitro and in vivo studies is deemed not sufficient to draw conclusions about the potential health effects of static magnetic field (SMF) exposure. Therefore, the aim of the present study was to determine the influence of static magnetic fields and phloretin on the redox homeostasis of human dermal fibroblasts. Control fibroblasts and fibroblasts treated with phloretin were subjected to the influence of static magnetic fields. Three chambers with static magnetic fields of different intensities (0...
August 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27067838/unaccounted-uncertainty-from-qpcr-efficiency-estimates-entails-uncontrolled-false-positive-rates
#9
Anders E Bilgrau, Steffen Falgreen, Anders Petersen, Malene K Kjeldsen, Julie S Bødker, Hans E Johnsen, Karen Dybkær, Martin Bøgsted
BACKGROUND: Accurate adjustment for the amplification efficiency (AE) is an important part of real-time quantitative polymerase chain reaction (qPCR) experiments. The most commonly used correction strategy is to estimate the AE by dilution experiments and use this as a plug-in when efficiency correcting the Δ Δ C q . Currently, it is recommended to determine the AE with high precision as this plug-in approach does not account for the AE uncertainty, implicitly assuming an infinitely precise AE estimate...
2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27048750/rna-sequencing-quantification-of-xenobiotic-processing-genes-in-various-sections-of-the-intestine-in-comparison-to-the-liver-of-male-mice
#10
Zidong Donna Fu, Felcy Pavithra Selwyn, Julia Yue Cui, Curtis D Klaassen
Previous reports on tissue distribution of xenobiotic-processing genes (XPGs) have limitations, because many non-cytochrome P450 phase I enzymes have not been investigated, and one cannot compare the real mRNA abundance of multiple XPGs using conventional quantification methods. Therefore, this study aimed to quantify and compare the mRNA abundance of all major XPGs in the liver and intestine using RNA sequencing. The mRNA profiles of 304 XPGs, including phase I, phase II enzymes, phase II cosubstrate synthetic enzymes, xenobiotic transporters, as well as xenobiotic-related transcription factors, were systematically examined in the liver and various sections of the intestine in adult male C57BL/6J mice...
June 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27044314/effect-of-n-3-fatty-acids-on-the-expression-of-inflammatory-genes-in-thp-1-macrophages
#11
Bénédicte Allam-Ndoul, Frédéric Guénard, Olivier Barbier, Marie-Claude Vohl
BACKGROUND: Uncontrolled inflammation participates in the development of inflammatory diseases. Beneficial effects of polyunsaturated fatty acids belonging to the n-3 family such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on inflammation have been reported. The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Β, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26961909/lactococcus-lactis-is-an-efficient-expression-system-for-mammalian-membrane-proteins-involved-in-liver-detoxification-cyp3a4-and-mgst1
#12
Sana Bakari, Mehdi Lembrouk, Laura Sourd, Fares Ousalem, François André, Stéphane Orlowski, Marcel Delaforge, Annie Frelet-Barrand
Despite the great importance of human membrane proteins involved in detoxification mechanisms, their wide use for biochemical approaches is still hampered by several technical difficulties considering eukaryotic protein expression in order to obtain the large amounts of protein required for functional and/or structural studies. Lactococcus lactis has emerged recently as an alternative heterologous expression system to Escherichia coli for proteins that are difficult to express. The aim of this work was to check its ability to express mammalian membrane proteins involved in liver detoxification, i...
April 2016: Molecular Biotechnology
https://www.readbyqxmd.com/read/26613780/targeted-imputation-of-sequence-variants-and-gene-expression-profiling-identifies-twelve-candidate-genes-associated-with-lactation-volume-composition-and-calving-interval-in-dairy-cattle
#13
Lesley-Ann Raven, Benjamin G Cocks, Kathryn E Kemper, Amanda J Chamberlain, Christy J Vander Jagt, Michael E Goddard, Ben J Hayes
Dairy cattle are an interesting model for gaining insights into the genes responsible for the large variation between and within mammalian species in the protein and fat content of their milk and their milk volume. Large numbers of phenotypes for these traits are available, as well as full genome sequence of key founders of modern dairy cattle populations. In twenty target QTL regions affecting milk production traits, we imputed full genome sequence variant genotypes into a population of 16,721 Holstein and Jersey cattle with excellent phenotypes...
February 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/26349522/soyabean-glycinin-depresses-intestinal-growth-and-function-in-juvenile-jian-carp-cyprinus-carpio-var-jian-protective-effects-of-glutamine
#14
Wei-Dan Jiang, Kai Hu, Jin-Xiu Zhang, Yang Liu, Jun Jiang, Pei Wu, Juan Zhao, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou, Lin Feng
This study investigated the effects of glycinin on the growth, intestinal oxidative status, tight junction components, cytokines and apoptosis signalling factors of fish. The results showed that an 80 g/kg diet of glycinin exposure for 42 d caused poor growth performance and depressed intestinal growth and function of juvenile Jian carp (Cyprinus carpio var. Jian). Meanwhile, dietary glycinin exposure induced increases in lipid peroxidation and protein oxidation; it caused reductions in superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) activities; and it increased MnSOD, CuZnSOD, GPx1b and GPx4a mRNA levels, suggesting an adaptive mechanism against stress in the intestines of fish...
November 28, 2015: British Journal of Nutrition
https://www.readbyqxmd.com/read/26091520/common-genetic-variation-in-cellular-transport-genes-and-epithelial-ovarian-cancer-eoc-risk
#15
Ganna Chornokur, Hui-Yi Lin, Jonathan P Tyrer, Kate Lawrenson, Joe Dennis, Ernest K Amankwah, Xiaotao Qu, Ya-Yu Tsai, Heather S L Jim, Zhihua Chen, Ann Y Chen, Jennifer Permuth-Wey, Katja K H Aben, Hoda Anton-Culver, Natalia Antonenkova, Fiona Bruinsma, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Maria Bisogna, Line Bjorge, Natalia Bogdanova, Louise A Brinton, Angela Brooks-Wilson, Clareann H Bunker, Ralf Butzow, Ian G Campbell, Karen Carty, Jenny Chang-Claude, Linda S Cook, Daniel W Cramer, Julie M Cunningham, Cezary Cybulski, Agnieszka Dansonka-Mieszkowska, Andreas du Bois, Evelyn Despierre, Ed Dicks, Jennifer A Doherty, Thilo Dörk, Matthias Dürst, Douglas F Easton, Diana M Eccles, Robert P Edwards, Arif B Ekici, Peter A Fasching, Brooke L Fridley, Yu-Tang Gao, Aleksandra Gentry-Maharaj, Graham G Giles, Rosalind Glasspool, Marc T Goodman, Jacek Gronwald, Patricia Harrington, Philipp Harter, Alexander Hein, Florian Heitz, Michelle A T Hildebrandt, Peter Hillemanns, Claus K Hogdall, Estrid Hogdall, Satoyo Hosono, Anna Jakubowska, Allan Jensen, Bu-Tian Ji, Beth Y Karlan, Linda E Kelemen, Mellissa Kellar, Lambertus A Kiemeney, Camilla Krakstad, Susanne K Kjaer, Jolanta Kupryjanczyk, Diether Lambrechts, Sandrina Lambrechts, Nhu D Le, Alice W Lee, Shashi Lele, Arto Leminen, Jenny Lester, Douglas A Levine, Dong Liang, Boon Kiong Lim, Jolanta Lissowska, Karen Lu, Jan Lubinski, Lene Lundvall, Leon F A G Massuger, Keitaro Matsuo, Valerie McGuire, John R McLaughlin, Iain McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Kirsten B Moysich, Roberta B Ness, Heli Nevanlinna, Ursula Eilber, Kunle Odunsi, Sara H Olson, Irene Orlow, Sandra Orsulic, Rachel Palmieri Weber, James Paul, Celeste L Pearce, Tanja Pejovic, Liisa M Pelttari, Malcolm C Pike, Elizabeth M Poole, Harvey A Risch, Barry Rosen, Mary Anne Rossing, Joseph H Rothstein, Anja Rudolph, Ingo B Runnebaum, Iwona K Rzepecka, Helga B Salvesen, Eva Schernhammer, Ira Schwaab, Xiao-Ou Shu, Yurii B Shvetsov, Nadeem Siddiqui, Weiva Sieh, Honglin Song, Melissa C Southey, Beata Spiewankiewicz, Lara Sucheston, Soo-Hwang Teo, Kathryn L Terry, Pamela J Thompson, Lotte Thomsen, Ingvild L Tangen, Shelley S Tworoger, Anne M van Altena, Robert A Vierkant, Ignace Vergote, Christine S Walsh, Shan Wang-Gohrke, Nicolas Wentzensen, Alice S Whittemore, Kristine G Wicklund, Lynne R Wilkens, Anna H Wu, Xifeng Wu, Yin-Ling Woo, Hannah Yang, Wei Zheng, Argyrios Ziogas, Hanis N Hasmad, Andrew Berchuck, Edwin S Iversen, Joellen M Schildkraut, Susan J Ramus, Ellen L Goode, Alvaro N A Monteiro, Simon A Gayther, Steven A Narod, Paul D P Pharoah, Thomas A Sellers, Catherine M Phelan
BACKGROUND: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk...
2015: PloS One
https://www.readbyqxmd.com/read/26066610/trimeric-microsomal-glutathione-transferase-2-displays-one-third-of-the-sites-reactivity
#16
Shabbir Ahmad, Madhuranayaki Thulasingam, Isolde Palombo, Daniel O Daley, Kenneth A Johnson, Ralf Morgenstern, Jesper Z Haeggström, Agnes Rinaldo-Matthis
Human microsomal glutathione transferase 2 (MGST2) is a trimeric integral membrane protein that belongs to the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) family. The mammalian MAPEG family consists of six members where four have been structurally determined. MGST2 activates glutathione to form a thiolate that is crucial for GSH peroxidase activity and GSH conjugation reactions with electrophilic substrates, such as 1-chloro-2,4-dinitrobenzene (CDNB). Several studies have shown that MGST2 is able to catalyze a GSH conjugation reaction with the epoxide LTA4 forming the pro-inflammatory LTC4...
October 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/25896808/compound-mouse-mutants-of-bzip-transcription-factors-mafg-and-mafk-reveal-a-regulatory-network-of-non-crystallin-genes-associated-with-cataract
#17
Smriti A Agrawal, Deepti Anand, Archana D Siddam, Atul Kakrana, Soma Dash, David A Scheiblin, Christine A Dang, Anne M Terrell, Stephanie M Waters, Abhyudai Singh, Hozumi Motohashi, Masayuki Yamamoto, Salil A Lachke
Although majority of the genes linked to early-onset cataract exhibit lens fiber cell-enriched expression, our understanding of gene regulation in these cells is limited to function of just eight transcription factors and largely in the context of crystallins. We report on small Maf transcription factors Mafg and Mafk as regulators of several non-crystallin human cataract-associated genes in fiber cells and establish their significance to this disease. We applied a bioinformatics tool for cataract gene discovery iSyTE to identify Mafg and its co-regulators in the lens, and generated various null-allelic combinations of Mafg:Mafk mouse mutants for phenotypic and molecular analysis...
July 2015: Human Genetics
https://www.readbyqxmd.com/read/25781442/association-of-aspirin-and-nsaid-use-with-risk-of-colorectal-cancer-according-to-genetic-variants
#18
Hongmei Nan, Carolyn M Hutter, Yi Lin, Eric J Jacobs, Cornelia M Ulrich, Emily White, John A Baron, Sonja I Berndt, Hermann Brenner, Katja Butterbach, Bette J Caan, Peter T Campbell, Christopher S Carlson, Graham Casey, Jenny Chang-Claude, Stephen J Chanock, Michelle Cotterchio, David Duggan, Jane C Figueiredo, Charles S Fuchs, Edward L Giovannucci, Jian Gong, Robert W Haile, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, John L Hopper, Thomas J Hudson, Mark A Jenkins, Shuo Jiao, Noralane M Lindor, Mathieu Lemire, Loic Le Marchand, Polly A Newcomb, Shuji Ogino, Bethann M Pflugeisen, John D Potter, Conghui Qu, Stephanie A Rosse, Anja Rudolph, Robert E Schoen, Fredrick R Schumacher, Daniela Seminara, Martha L Slattery, Stephen N Thibodeau, Fridtjof Thomas, Mark Thornquist, Greg S Warnick, Brent W Zanke, W James Gauderman, Ulrike Peters, Li Hsu, Andrew T Chan
IMPORTANCE: Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE: To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use of aspirin and/or NSAIDs and single-nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS: Case-control study using data from 5 case-control and 5 cohort studies initiated between 1976 and 2003 across the United States, Canada, Australia, and Germany and including colorectal cancer cases (n=8634) and matched controls (n=8553) ascertained between 1976 and 2011...
March 17, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25553083/chemopreventive-effects-of-korean-red-ginseng-extract-on-rat-hepatocarcinogenesis
#19
Hyemee Kim, Mi-Kyung Hong, Haymie Choi, Hyun-Seuk Moon, Hae-Jeung Lee
The objective of this study was to determine a chemopreventive activity of Korean red ginseng extract (KRG) in diethylnitrosamine (DEN) induced hepatocarcinogenesis in rats. After acclimatization for a week, Sprague-Dawley rats were randomized into five groups (n = 15) and fed either KRG (0.5, 1 or 2%) or control diets for 10 weeks. After two weeks of starting of experimental diets, the rats were initiated hepatocarcinogenesis by injection of DEN and were then subjected to two-thirds partial hepatectomy at five-week for developing the medium-term bioassay system...
2015: Journal of Cancer
https://www.readbyqxmd.com/read/25379386/prenatal-expression-of-thioredoxin-reductase-1-trxr1-and-microsomal-glutathione-transferase-1-mgst1-in-humans
#20
Linda Björkhem-Bergman, Maria Johansson, Ralf Morgenstern, Anders Rane, Lena Ekström
Thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) are important redox and detoxifying enzymes in adult life. The aim of this study was to investigate the expression of these enzymes during fetal life. In addition, the role of gene methylation was studied since this might play an important role in the on-and-off switch of gene expression between fetal and adult life. To this end, the expression of the TRXR1-encoding gene TXNRD1 and the MGST1-encoding gene MGST1 was studied in fetal tissues...
2014: FEBS Open Bio
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