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https://www.readbyqxmd.com/read/29783824/-clinical-analysis-of-seven-cases-of-rare-hemolytic-disease-of-the-newborn
#1
S Gu, H X Wang, C Y Yang, X F Yang, Y Lin, Y Zhong, J P He, Y J Wang
Objective: To summarize the clinical features of 7 rare cases of hemolytic disease of newborn (HDN), and to improve the understanding of rare HDN. Methods: Data of clinical information, laboratory findings, treatments and outcomes were collected and analyzed for four cases with HDN due to anti-M, two cases due to anti-Kidd, and one case due to anti-Duffy. All of them were admitted to the Department of Neonatology, Beijing Children's Hospital Affiliated to Capital Medial University from July 2007 to June 2017...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29782390/suspecting-hyperferritinemic-sepsis-in-iron-deficient-population-do-we-need-a-lower-plasma-ferritin-threshold
#2
Swarup Ghosh, Arun K Baranwal, Prateek Bhatia, Karthi Nallasamy
OBJECTIVES: Hyperferritinemia is being suggested to identify patients with sepsis-induced macrophage activation syndrome for early intervention. However, data among iron-deficient children are scarce. This study was planned to explore the biological behavior of plasma ferritin in children from communities with a high frequency of iron deficiency with septic shock and its association with the outcome. DESIGN: Prospective observational study. SETTING: Tertiary care teaching hospital in a low-middle income economy of South Asia...
May 18, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29779995/factors-predicting-postoperative-febrile-urinary-tract-infection-following-percutaneous-nephrolithotomy-in-prepubertal-children
#3
Onur Kaygısız, Nihat Satar, Ali Güneş, Hasan Serkan Doğan, Ahmet Erözenci, Ender Özden, Mehmet Mesut Pişkin, Deniz Demirci, Serdar Toksöz, Tufan Çiçek, Serhat Gürocak, Hakan Kılıçarslan, Oktay Nazlı, Aykut Kefi, Volkan İzol, Ali Beytur, Şaban Sarıkaya, Serdar Tekgül, Bülent Önal
BACKGROUND: Predictive tables and scoring systems can predict stone clearance. However, there is a paucity of evidence regarding the prediction of complications during percutaneous nephrolithotomy (PCNL), particularly in children, which remains under-researched. To our knowledge, no studies have evaluated the risk factors for febrile urinary tract infection (FUTI) after pediatric PCNL. OBJECTIVES: To assess the predictive factors of FUTI in prepubertal children after PCNL and determine whether any prophylactic cephalosporins are superior for decreasing the FUTI rate...
May 5, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29778713/concluding-commentary-on-current-trends-to-enhance-the-clinical-safety-of-pediatric-transfusion-focusing-on-prevention-of-untoward-complications-of-hsc-transplantation-newer-strategies-for-improving-the-standards-of-safety-quality-of-stem-cells-expansion-for
#4
REVIEW
Irena Sniecinski, Jerard Seghatchian
Clinical practice and related diagnostic, development and research [DDR] strategies in pediatric transfusion and transplantation cover a broad range of multidisciplinary studies, performed by many professionals involved in this most challenging clinical field [1]. This commentary on the current position and future perspectives in pediatric transfusion field is aimed to highlight major unresolved transfusion complications in pediatric patients, namely red blood cell and platelet alloimmunisation, and new ones such as nosocomial infection, thrombosis and multi-organ failure...
May 16, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29771828/results-following-adoption-of-a-modified-melbourne-technique-of-total-scaphocephaly-correction
#5
Julia D Sharma, Justine L O'Hara, Alessandro Borghi, Naiara Florez-Rodriguez, William Breakey, Juling Ong, Nu Owase Jeelani, David J Dunaway, Greg James
The Melbourne technique was described in 2008 as a novel method for complete correction of scaphocephaly. Since 2015, it has become our operation of choice for children with sagittal synostosis who are too old at presentation for minimally invasive techniques. Our modifications were 2-position (initially supine then prone) technique and undertaking a formal fronto-orbital remodeling to correct forehead contour. Retrospective chart review was used to record demographics, blood transfusion frequency and volumes, operating time, length of stay, clinical outcome, and complications...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29762453/microvascular-replantation-following-facial-dog-bites-in-children-systematic-review-and-management-algorithm
#6
Amanda J Williams, Jeremy M Powers, Jennifer L Rhodes, Andrea L Pozez
BACKGROUND: Pediatric dog bite injuries account for 1% of emergency department visits per year and represent an underrecognized and underreported public health problem. Reconstructive surgery is frequently utilized, and in the most extreme injuries, microvascular replantation may be considered. We sought to systematically review the available literature on microvascular replantation after facial dog bite injuries in children, with particular attention to perioperative morbidity and long-term follow-up...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762364/seroprevalence-of-toxoplasma-gondii-infection-among-%C3%AE-thalassemia-major-pediatric-population-implications-for-transfusion-transmissible-toxoplasmosis
#7
Nora El-Tantawy, Ahmad Darwish, Eman Eissa
BACKGROUND: Children with β-thalassemia major who regularly receive blood transfusion are at risk of developing transfusion-transmitted infection. Toxoplasmosis is a common and a serious parasitic disease with high prevalence and could be transmitted through blood transfusion from healthy asymptomatic donors. However, screening Toxoplasma gondii before blood donation has not been considered. OBJECTIVE: To determine the prevalence of T. gondii antibodies among thalassemia children undergoing blood transfusion...
May 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29762328/treatment-of-craniosynostosis-the-impact-of-hospital-surgical-volume-on-cost-resource-utilization-and-outcomes
#8
Anmol Chattha, Alexandra Bucknor, Daniel A Curiel, Klaas H J Ultee, Salim Afshar, Samuel J Lin
The authors aim to quantify the impact of hospital volume of craniosynostosis surgery on inpatient complications and resource utilization using national data. Children <12 months with nonsyndromic craniosynostosis who underwent surgery in 2012 at academic hospitals in the United States were identified from the Kids' Inpatient Database (KID) developed by the Healthcare Cost and Utilization Project (HCUP). Hospital craniosynostosis surgery volume was stratified into tertiles based on total annual hospital cases: low volume (LV, 1-13), intermediate volume (IV, 14-34), and high volume (HV, ≥35)...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29761839/effects-of-plasma-transfusions-on-antithrombin-levels-after-paediatric-liver-transplantation
#9
D Arni, B E Wildhaber, V McLin, P C Rimensberger, M Ansari, P Fontana, O Karam
BACKGROUND AND OBJECTIVES: Thrombotic complications affect 3-10% of patients after liver transplantation (LT), leading to potentially life-threatening complications. In the days following LT, antithrombin (AT) is decreased longer than pro-coagulant factors, thus favouring a pro-thrombotic profile. Plasma transfusions are given empirically in some centres to correct AT levels following LT. We assessed the effect of plasma transfusion on AT levels after paediatric LT. MATERIALS AND METHODS: Prospective single-centre observational study in 20 consecutive paediatric LT recipients over a 24-month period...
May 15, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29761226/renal-stone-composition-does-not-affect-the-outcome-of-percutaneous-nephrolithotomy-in-children
#10
Onur Kaygısız, Fethi Ahmet Türegün, Nihat Satar, Ender Özen, Serdar Toksöz, Hasan Serkan Doğan, Mehmet Mesut Pişkin, Volkan İzol, Şaban Sarıkaya, Hakan Kılıçarslan, Tufan Çiçek, Ahmet Öztürk, Serdar Tekgül, Bülent Önal
PURPOSE: We sought to investigate the association between renal stone composition and percutaneous nephrolithotomy outcomes in pediatric patients and define the characterization of the stone composition. METHODS: The data of 1157 children who underwent percutaneous nephrolithotomy between 1991 and 2012 were retrieved from the multicenter database of the Turkish Pediatric Urology Society. The study population comprised 359 children (160 girls, 199 boys) with stone analyses...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29755902/efficacy-and-safety-of-wheat-grass-in-thalassemic-children-on-regular-blood-transfusion
#11
Amit S Mutha, Kalpana U Shah, Aarti A Kinikar, Balasaheb B Ghongane
BACKGROUND: In thalassemia, mutations either in alpha or beta chain synthesis results in low hemoglobin (Hb). Wheatgrass has been used for many years for health purposes. Some reports suggest the beneficial effect of wheatgrass on transfusion requirements. Folic acid is also known to play an important role in several biochemical reactions. In some patients with thalassemia, the supplementation of folic acid is useful. OBJECTIVE: To evaluate the efficacy and safety of wheatgrass in children with thalassemia receiving chronic blood transfusions...
March 11, 2018: Curēus
https://www.readbyqxmd.com/read/29755625/minimal-invasive-technique-in-atrial-septal-defect-surgery
#12
Feridoun Sabzi, Reza Faraji, Mahmood Kazeminasab
Background: Median sternotomy with minimal skin incision (MSWMSI) and modified anterior mini-thoracotomy (MAMT) approach that both are innovative techniques modified from previous documented techniques are important alternative to conventional median sternotomy in atrial septal defect (ASD) repair. Our aim is to explain the details of two performed techniques in our center and explain the results. Methods: Totally 54 children with ASD (20 female and 34 male) were operated with two different techniques i...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29727368/platelet-transfusion-practices-in-critically-ill-children
#13
Marianne E Nellis, Oliver Karam, Elizabeth Mauer, Melissa M Cushing, Peter J Davis, Marie E Steiner, Marisa Tucci, Simon J Stanworth, Philip C Spinella
OBJECTIVES: Little is known about platelet transfusions in pediatric critical illness. We sought to describe the epidemiology, indications, and outcomes of platelet transfusions among critically ill children. DESIGN: Prospective cohort study. SETTING: Multicenter (82 PICUs), international (16 countries) from September 2016 to April 2017. PATIENTS: Children ages 3 days to 16 years prescribed a platelet transfusion in the ICU during screening days...
May 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29709077/use-of-platelet-transfusions-prior-to-lumbar-punctures-or-epidural-anaesthesia-for-the-prevention-of-complications-in-people-with-thrombocytopenia
#14
REVIEW
Lise J Estcourt, Reem Malouf, Sally Hopewell, Carolyn Doree, Joost Van Veen
BACKGROUND: People with a low platelet count (thrombocytopenia) often require lumbar punctures or an epidural anaesthetic. Lumbar punctures can be diagnostic (haematological malignancies, subarachnoid haematoma, meningitis) or therapeutic (spinal anaesthetic, administration of chemotherapy). Epidural catheters are placed for administration of epidural anaesthetic. Current practice in many countries is to correct thrombocytopenia with platelet transfusions prior to lumbar punctures and epidural anaesthesia, in order to mitigate the risk of serious procedure-related bleeding...
April 30, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29706495/effect-of-red-blood-cell-storage-duration-on-outcome-after-paediatric-cardiac-surgery-a-prospective-observational-study
#15
Arvind Kumar Bishnoi, Pankaj Garg, Kartik Patel, Chandrasekaran Ananthanarayanan, Ritesh Shah, Atul Solanki, Himani Pandya, Sanjay Patel
BACKGROUND: Retrospective reviews have found the use of stored packed red blood cells (PRBCs) in priming to be associated with increased risk of postoperative complications. The purpose of study was to prospectively investigate the influence of duration of storage of PRBCs used in priming the cardiopulmonary bypass (CPB) circuit on the metabolic profile of the patients, and postoperative outcome after paediatric cardiac surgery. METHODS: Between January 2015 and December 2015, 198 consecutive children operated for cardiac surgery using CPB and received blood for priming the circuit were included...
March 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29706371/an-anticoagulation-protocol-for-use-after-congenital-cardiac-surgery
#16
Asha G Nair, Olubunmi O Oladunjoye, Cameron C Trenor, Meena LaRonde, Sarah J van den Bosch, Lynn A Sleeper, Christina VanderPluym, Sitaram M Emani, John N Kheir
BACKGROUND: Patients undergoing surgery for congenital heart disease are at high risk for bleeding as well as thrombosis in the postoperative period. The objective of the study was to describe the design and effects of implementing a standardized unfractionated heparin anticoagulation protocol for children after congenital heart surgery. METHODS: We created a tiered guideline for the postoperative management of bleeding and thrombosis. In patients treated with unfractionated heparin, anti-factor Xa activity level as well as activated partial thromboplastin time were used for dose titration...
April 7, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29692306/risk-factors-for-mortality-in-children-hospitalized-with-severe-malaria-in-northern-zambia-a-retrospective-case-control-study
#17
Matthew M Ippolito, Luc K Kamavu, Jean-Bertin Kabuya, Catherine Tente, Edward Chileshe, McBerth Wapachole, Philip E Thuma, Mbanga Muleba, Mike Chaponda, Modest Mulenga, William J Moss, For The Southern And Central Africa International Centers Of Excellence For Malaria Research
Malaria remains a public health crisis in areas where it has resisted control efforts. In Nchelenge District, a high- transmission area in northern Zambia, malaria accounts for more than one-third of pediatric hospitalizations and nearly one-half of hospital deaths in children. To identify risk factors for death due to malaria, we conducted a retrospective, time-matched case-control study of 126 children hospitalized with malaria who died (cases) and 126 children who survived (controls). There were no differences in age, gender, hemoglobin concentration, or prevalence of severe anemia between cases and controls...
April 23, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29677086/hematologic-adverse-events-associated-with-prolonged-valganciclovir-treatment-in-congenital-cytomegalovirus-infection
#18
Liron Ziv, Joanne Yacobovich, Joseph Pardo, Havatzelet Yarden-Bilavsky, Jacob Amir, Micky Osovsky, Efraim Bilavsky
BACKGROUND: Valganciclovir (2/d) therapy for 6 months in neonates with symptomatic congenital cytomegalovirus infection improves hearing and neurodevelopmental outcome. The only reported adverse event was neutropenia. Since 2009, our protocol for symptomatic congenital cytomegalovirus infection was a 1-year treatment of 2/d for the first 3 months followed by 9 months of 1/d. METHODS: A retrospective study. Infants with congenital cytomegalovirus treated with valganciclovir for 1 year were recruited...
April 19, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29667253/patient-blood-management-what-does-this-actually-mean-for-neonates-and-infants
#19
REVIEW
G L Crighton, H V New, H G Liley, S J Stanworth
Patient blood management (PBM) refers to an evidence-based package of care that aims to improve patient outcomes by optimal use of transfusion therapy, including managing anaemia, preventing blood loss and improving anaemia tolerance in surgical and other patients who may need transfusion. In adults, PBM programmes are well established, yet the definition and implementation of PBM in neonates and children lags behind. Neonates and infants are frequently transfused, yet they are often under-represented in transfusion trials...
April 17, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29666843/blood-transfusion-in-children-the-refusal-of-jehovah-s-witness-parents
#20
Adelaide Conti, Emanuele Capasso, Claudia Casella, Piergiorgio Fedeli, Francesco Antonio Salzano, Fabio Policino, Lucia Terracciano, Paola Delbon
In Italy, both parents have parental responsibility; as a general principle they have the power to give or withhold consent to medical procedures on their children, including consent for blood transfusion; however these rights are not absolute and exist only to promote the welfare of children. Methods: The Authors discuss ethical and legal framework for Jehovah's Witness parents' refusal of blood transfusion in Italy. They searched national judgments concerning Jehovah's Witness parents' refusal of blood transfusion - and related comments - in national legal databases and national legal journals, and literature on medical literature databases...
2018: Open Medicine (Warsaw, Poland)
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