keyword
https://read.qxmd.com/read/37867054/does-neo-adjuvant-chemotherapy-improve-the-negative-effect-of-lymphovascular-invasion-in-survival-after-radical-cystectomy
#21
JOURNAL ARTICLE
Hasan Yılmaz, Kerem Teke, Evren Süer, Volkan İzol, Hacı Murat Akgül, İsmail Selvi
PURPOSE: There is a lack of studies in the literature to evaluate the impact of the specific benefit of the use of neo-adjuvant chemotherapy (NAC) on the negative effect of lymphovascular invasion (LVI) on prognosis. We aimed to evaluate the survival differences of patients according to the presence of LVI with and without administration of NAC before radical cystectomy (RC). MATERIALS AND METHODS: We retrospectively evaluated data of the patients who underwent RC with pelvic lymphadenectomy and urinary diversion for bladder cancer recorded in the bladder cancer database of the Turkish Uro-oncology Association between 2007 and 2021...
October 20, 2023: Urologic Oncology
https://read.qxmd.com/read/37839981/large-language-models-in-uro-oncology
#22
EDITORIAL
Dyke Ferber, Jakob Nikolas Kather
No abstract text is available yet for this article.
October 13, 2023: European Urology Oncology
https://read.qxmd.com/read/37830863/working-to-improve-the-care-of-men-with-prostate-cancer
#23
JOURNAL ARTICLE
Leann Mclaughlin
Leann Mclaughlin , Uro-Oncology Clinical Nurse Specialist, Inverclyde Royal Hospital, Greenock ([email protected]), won a Bronze Award in the Urology Nurse of the Year category of the BJN Awards 2023.
October 12, 2023: British Journal of Nursing: BJN
https://read.qxmd.com/read/37816870/management-of-functional-outcomes-after-radical-prostatectomy-in-the-nordic-countries-a-survey-of-uro-oncological-centers
#24
JOURNAL ARTICLE
Alexander Bjørneboe Nolsøe, Henriette Veiby Holm, Teemu J Murtola, Peter Busch Østergren, Mikkel Fode
We aimed to describe the clinical practice regarding erectile dysfunction and urinary incontinence after radical prostatectomy in the Nordic countries. A 37-item survey about pre- and post-prostatectomy evaluation and rehabilitation of sexual and urinary function was sent to 42 uro-oncology centers. Reporting was done according to the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Twenty-seven centers in Denmark (n = 6), Norway (n = 8), Finland (n = 7), and Sweden (n = 6) responded (64...
October 10, 2023: International Journal of Impotence Research
https://read.qxmd.com/read/37794204/siuro-best-practice-recommendations-to-optimize-brca-1-2-gene-testing-from-dna-extracted-from-bone-biopsy-in-mcrpc-patients-brca-optimal-bone-biopsy-procedure-bop
#25
REVIEW
Alessia Cimadamore, Pasquale Rescigno, Vincenza Conteduca, Anna Caliò, Massimiliano Allegritti, Valentina Calò, Ilaria Montagnani, Roberta Lucianò, Margherita Patruno, Sergio Bracarda
The main guidelines and recommendations for the implementation of the BRCA1/2 somatic test do not focus on the clinical application of predictive testing on bone metastases, a frequent condition in metastatic prostate cancer, by analyzing the critical issues encountered by laboratory practice. Our goal is to produce a document (protocol) deriving from a multidisciplinary team approach to obtain high quality nucleic acids from biopsy of bone metastases. This document aims to compose an operational check-list of three phases: the pre-analytical phase concerns tumor cellularity, tissue processing, sample preservation (blood/FFPE), fixation and staining, but above all the decalcification process, the most critical phase because of its key role in allowing the extraction of somatic DNA with a good yield and high quality...
November 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37772591/abstracts-of-the-33rd-annual-meeting-of-the-italian-society-of-uro-oncology-siuro
#26
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
October 2023: Anticancer Research
https://read.qxmd.com/read/37704860/-role-of-nutrition-in-urological-prehabilitation
#27
REVIEW
Imke Thederan, Birgit-Christiane Zyriax, Hans Heinzer
Nutritional intervention plays an important role in prehabilitation, a multimodal concept designed to improve the physical condition of the patient prior to treatment in order to influence the outcome of surgery. The focus is on reducing the postoperative complication rate, while simultaneously shortening the hospital stay and the rehabilitation phase. The nutritional status should be optimized through individual counseling and the targeted intake of calories, protein, and nutritional supplements. A good nutritional status contributes to the strengthening of the immune system and improves wound healing...
September 13, 2023: Urologie
https://read.qxmd.com/read/37698690/qualitative-evaluation-of-the-life-experiences-of-spouses-of-prostate-cancer-patients-receiving-androgen-deprivation-therapy
#28
JOURNAL ARTICLE
Emre Ciydem, Tugba Sinmaz
PURPOSE: This study was conducted to qualitatively evaluate the life experiences of women whose spouses had been receiving androgen deprivation therapy. METHODS: The purposive sample of the research, in which a descriptive phenomenological design was used, consisted of 15 women. The data were evaluated according to Colaizzi's phenomenological analysis steps. RESULTS: The views of the participants were classified into 7 themes: loss and grief, physical difficulties, socioeconomic difficulties, psychological difficulties, relational changes, strengths, and benefits...
September 12, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/37656184/-prehabilitation-prior-to-radical-cystectomy
#29
REVIEW
Matthias Giese, Marius Butea-Bocu, Johannes Huber, Christer Groeben
Urothelial carcinoma of the urinary bladder places a significant burden on the healthcare system in Germany, with 30,000 new cases annually. Radical cystectomy still remains the standard treatment for nonmetastatic, muscle invasive bladder cancer. Radical cystectomy represents the standard uro-oncologic procedure with the highest mortality. Due to the aging population, the number of elderly patients with urothelial carcinoma of the urinary bladder and reduced physical fitness and numerous comorbidities before the procedure is increasing...
September 1, 2023: Urologie
https://read.qxmd.com/read/37607583/-neutropenia-when-is-gcsf-support-indicated
#30
JOURNAL ARTICLE
Marc Rehlinghaus, Philipp Rehker, Yue Che, Camilla Marisa Grunewald, Günter Niegisch
Many systemic treatments used in genitourinary oncology negatively affect haematopoiesis, thus leading to neutropenia. Neutropenic patients are vulnerable to bacterial, and other infections. Often fever is the only symptom in these patients. Neutropenic fever is a major threat for these patients, as it may lead to life-threatening therapy complications that significantly impair the patient's quality of life, Moreover, it may also worsen the prognosis due to therapy delays or necessary dose modifications. Granulocyte colony stimulating factors (GCSF), which can improve neutrophil granulocyte formation, are used both for supportive treatment in febrile neutropenia and for its prophylaxis...
August 22, 2023: Aktuelle Urologie
https://read.qxmd.com/read/37607581/-emergencies-in-cancer-immunotherapy
#31
JOURNAL ARTICLE
Analena Handke, Thomas Hilser, Martin Bögemann, Katrin Schlack, Viktor Grünwald
BACKGROUND: Immunomodulatory therapies are becoming increasingly important in uro-oncology. For this reason, we will probably be increasingly confronted with side effects. In addition, there is an increasing number of combinations with other mechanisms of action. Immune-mediated side effects may occur as a consequence of this therapy. These are different from the side effects of chemotherapy and other targeted therapies and therefore require different treatment strategies. AIM: Based on the current literature, the data on graduation and stage-dependent management will be presented as well as illustrated with examples from practice...
August 22, 2023: Aktuelle Urologie
https://read.qxmd.com/read/37606656/-exercise-therapy-in-prehabilitation-current-findings-in-urology
#32
REVIEW
Michael Mendes Wefelnberg, Nadine Reimer, Freerk T Baumann
BACKGROUND: Prehabilitation refers to interventions that take place before starting medical treatment. Prehabilitation exercise therapy aims to increase functional physical capacities to improve recovery and reduce side effects. OBJECTIVES: To present the evidence and potential of prehabilitation exercise therapy in urological oncology. METHODS: Compilation and explanation of study results. RESULTS: Studies are limited and primarily focused on prostate and bladder cancer...
August 22, 2023: Urologie
https://read.qxmd.com/read/37606251/a-supervised-machine-learning-approach-for-the-efficient-development-of-a-multi-method-lc-ms-for-a-large-number-of-drugs-and-subsets-thereof-focus-on-oral-antitumor-agents
#33
JOURNAL ARTICLE
Niklas Kehl, Arne Gessner, Renke Maas, Martin F Fromm, R Verena Taudte
OBJECTIVES: Accumulating evidence argues for a more widespread use of therapeutic drug monitoring (TDM) to support individualized medicine, especially for therapies where toxicity and efficacy are critical issues, such as in oncology. However, development of TDM assays struggles to keep pace with the rapid introduction of new drugs. Therefore, novel approaches for faster assay development are needed that also allow effortless inclusion of newly approved drugs as well as customization to smaller subsets if scientific or clinical situations require...
August 23, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37591208/a-retrospective-analysis-of-83-patients-with-testicular-mass-who-underwent-testis-sparing-surgery-the-eurasian-uro-oncology-association-multicenter-study
#34
JOURNAL ARTICLE
Murat Keske, Abdullah Erdem Canda, Mert Ali Karadag, Halil Çiftçi, Sakip Erturhan, Cagri Kactan, Mustafa Soytas, Fatih Özkaya, Isa Ozbey, Eser Ordek, Ali Fuat Atmaca, Asif Yildirim, Selcuk Sahin, Yunus Colakoglu, Ugur Boylu, Bulent Erol, Turhan Caskurlu, Murat Can Kiremit, Ozer Ural Cakici, Gokhan Sonmez, Hakan Kılıçarslan, Ziya Akbulut, Onur Kaygısız, Selahattin Bedir, Hakan Vuruskan, Yunus Erol Bozkurt, Hasan Riza Aydin, Ural Oguz, Erem Kaan Basok, Bilal Habes Gumus, Altug Tuncel, Yilmaz Aslan, Nurullah Hamidi, Ahmet Yaser Müslümanoğlu, Murat Dinçer, Derya Balbay, Selami Albayrak, Maria Pilar Laguna
INTRODUCTION: Herein, we analyzed the histopathological, oncological and functional outcomes of testis-sparing surgery (TSS) in patients with distinct risk for testicular cancer. METHODS: This is a multicenter retrospective study on consecutive patients who underwent TSS. Patients were categorized in high- or low-risk testicular germ cell tumor (TGCT) according to the presence/absence of features compatible with testicular dysgenesis syndrome. Histology was categorized per size and risk groups...
August 17, 2023: Urologia Internationalis
https://read.qxmd.com/read/37530670/the-quality-of-life-value-in-uro-oncological-patients
#35
JOURNAL ARTICLE
Marcello Della Corte, Francesco Porpiglia, Enrico Checcucci
No abstract text is available yet for this article.
September 1, 2023: Current Opinion in Urology
https://read.qxmd.com/read/37492363/urine-cytology-and-axillary-testing-for-interpretation-and-follow-up-of-urinary-tumors
#36
REVIEW
Alexandra M Kalogeraki, Dimitrios I Tamiolakis, Charalampos K Mamoulakis
Microscopic appearance of cells in urine cytological samples is the formal diagnostic approach adjunct to cystoscopy for the detection and follow-up of urinary tumors. However, cystoscopy is a surgical method and cytology may miss low-grade papillary tumors. Several assays and markers have been developed to assist in this. When combined with conventional cytology, uro-oncological diagnostic performance is improved. We review the value of these non-invasive modalities in comparison with urine cytomorphology in the work-up of urothelial malignancies...
November 2022: Acta Clinica Croatica
https://read.qxmd.com/read/37425192/quantitative-ultrasound-of-the-calcaneus-qus-a-valuable-tool-in-the-identification-of-patients-with-non-metastatic-prostate-cancer-requiring-screening-for-osteoporosis
#37
JOURNAL ARTICLE
B B Nieuwkamer, J P M Vrouwe, P M Willemse, M P J Nicolai, R F M Bevers, R C M Pelger, N A T Hamdy, S Osanto
UNLABELLED: Non-metastatic prostate cancer (PCa) patients are at increased risk for osteoporosis and fractures mainly due to androgen deprivation therapy (ADT)-associated hypogonadism, but this remains largely underdiagnosed and untreated. In this study, we examine the value of pre-screening calcaneal QUS in identifying patients who should be referred for screening for osteoporosis using dual-energy X-Ray absorptiometry (DXA). In a single-center retrospective cross-sectional cohort study, we analysed data on DXA and calcaneal QUS measurements systematically collected between 2011 and 2013 in all non-metastatic PCa patients attending our Uro-Oncological Clinic at the Leiden University Medical Center...
June 2023: Bone Reports
https://read.qxmd.com/read/37378080/real-world-experience-of-cabozantinib-in-asian-patients-with-advanced-renal-cell-carcinoma-following-treatment-with-vegfr-tyrosine-kinase-inhibitors-and-or-immune-checkpoint-inhibitors
#38
JOURNAL ARTICLE
Darren Mc Poon, Kuen Chan, Angus Kwong-Chuen Leung, Brian Ng, Foon-Yiu Cheung, Steven Wai-Kwan Siu
BACKGROUND: There is a lack of real-world data on the use of cabozantinib in Asian patients with metastatic renal cell carcinoma. METHODS: We conducted a retrospective study to investigate the toxicity and efficacy of cabozantinib in this patient population who progressed on tyrosine kinase inhibitors and/or immune-checkpoint inhibitors from six oncology centres in Hong Kong. The primary endpoint was the incidence of serious adverse events (AEs) attributed to cabozantinib...
2023: Drugs in Context
https://read.qxmd.com/read/37350584/a-survey-on-preferences-attitudes-and-perspectives-of-italian-urology-trainees-implications-of-the-novel-national-residency-matching-program
#39
JOURNAL ARTICLE
Luigi Napolitano, Martina Maggi, Gianluca Sampogna, Marta Bianco, Marco Campetella, Marco Carilli, Marco Lucci Chiarissi, Angelo Civitella, Francesco DE Vita, Fabrizio DI Maida, Marina DI Mauro, Amelio Ercolino, Vittorio Fasulo, Graziano Felici, Alberto Gheza, Calogero Guzzardo, Davide Loizzo, Elio Mazzone, Stefano Parodi, Federico Piramide, Salvatore Rabito, Riccardo Rizzetto, Federico Romantini, Simone Scarcella, Matteo Tedde, Enrico Checcucci, Francesco Esperto, Francesco Claps, Ugo Falagario
BACKGROUND: Since 2014, a new residency program selection process has been established with a national examination. The aim of this study was to assess characteristics, career goals, and practice preferences of current Italian urology residents. METHODS: A web-based survey of 25 items performed from May 2021 to September 2021 was sent to 585 Italian urology residents. Descriptive analyses were conducted to describe the surveys' domains: demographics characteristics, studies, plans for fellowship training, interest in the urology field, and career expectations...
June 23, 2023: Minerva urology and nephrology
https://read.qxmd.com/read/37345119/survival-in-kidney-and-bladder-cancers-in-four-nordic-countries-through-a-half-century
#40
JOURNAL ARTICLE
Filip Tichanek, Asta Försti, Akseli Hemminki, Otto Hemminki, Kari Hemminki
Kidney and bladder cancers share etiology and relatively good recent survival, but long-term studies are rare. We analyzed survival for these cancers in Denmark, Finland, Norway (NO), and Sweden (SE) over a 50-year period (1971-2020). Relative 1- and 5-year survival data were obtained from the NORDCAN database, and we additionally calculated conditional 5/1-year survival. In 2016-2020, 5-year survivals for male kidney (79.0%) and bladder (81.6%) cancers were best in SE. For female kidney cancer, NO survival reached 80...
May 16, 2023: Cancers
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