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https://www.readbyqxmd.com/read/28766004/-psychosocial-stress-in-patients-with-prostate-cancer-experiences-by-using-psychooncological-screening-questionnaires
#1
D L Dräger, N N Harke, K-D Sievert, C Protzel, O W Hakenberg
BACKGROUND: Prostate cancer is the most common malignancy in men and accounts for most surgical procedures in uro-oncology. Stressful sequelae of radical prostatectomy are incontinence and erectile dysfunction. Hormone ablation and radiation therapy are also known stressors. Mental stress has a low prevalence compared to other tumor entities. It is highly probable that there is an underexpression of verbally reported emotional experiences. Therefore, a low-threshold access to psycho-oncological services and accurate identification of patients with mental comorbidities is important...
August 1, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28753804/variability-in-outcomes-for-patients-with-intermediate-risk-prostate-cancer-gleason-score-7-international-society-of-urological-pathology-gleason-group-2-3-and-implications-for-risk-stratification-a-systematic-review
#2
REVIEW
Christopher J Kane, Scott E Eggener, Alan W Shindel, Gerald L Andriole
CONTEXT: Optimal management for patients with intermediate-risk (IR) prostate cancer (PCa) remains controversial. Clinical metrics provide guidance on appropriate management options. OBJECTIVE: To report estimates for clinically relevant outcomes in men with IR PCa based on clinical and pathological features. EVIDENCE ACQUISITION: PubMed and programs from key 2015 uro-oncology congresses were searched using the terms "intermediate", "Gleason 3 + 4", "Gleason 4 + 3", "active surveillance", "treatment", "adverse pathology", AND "prostate cancer...
March 11, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28721462/-outpatient-specialist-treatment-%C3%A2-%C3%A2-116b-new-changes-pending-in-outpatient-uro-oncology
#3
REVIEW
A Schroeder
No abstract text is available yet for this article.
July 18, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28719043/implementation-rates-of-uro-oncology-multi-disciplinary-meeting-decisions
#4
Ned Kinnear, Riley Smith, Derek B Hennessey, Damien Bolton, Shomik Sengupta
OBJECTIVES: To assess implementation rates of the consensus plans made at the uro-oncology multidisciplinary meeting (MDM) of an Australian tertiary centre, and analyse obstacles to implementation. METHODS: A retrospective review was performed of all patients discussed at the uro-oncology MDM at our institution between 1 January to 30 June 2015. Rates of referral for MDM discussion following a new histological diagnosis of malignancy, categorised by tumour type, were assessed...
July 18, 2017: BJU International
https://www.readbyqxmd.com/read/28659719/somatic-mutation-analyses-in-studies-of-the-clonal-evolution-and-diagnostic-targets-of-prostate-cancer
#5
REVIEW
Dmitry S Mikhaylenko, Gennady D Efremov, Vladimir V Strelnikov, Dmitry V Zaletaev, Boris Y Alekseev
Prostate cancer (PC) is the most common uro-oncological disease in the global population and still requires a more efficient laboratory diagnosis. Point mutations of oncogenes and tumor sup-pressor genes are the most frequent molecular genetic events in carcinogenesis. The mutations are re-sponsible, to a great extent, for the clonal evolution of cancer and can be considered as primary candi-date molecular markers of PC. Using next-generation sequencing to analyze the mutations in PC, the main molecular PC subtypes were identified, which depended on the presence of fusion genes and FOXA1, CHD1, and SPOP point mutations; other driver mutations responsible for the progression of PC subclones were also characterized...
June 2017: Current Genomics
https://www.readbyqxmd.com/read/28652879/are-renal-tumour-scoring-systems-better-than-clinical-judgement-at-predicting-partial-nephrectomy-complexity
#6
Ravi M Kumar, Luke T Lavallée, Darren Desantis, Sonya Cnossen, Ranjeeta Mallick, Ilias Cagiannos, Chris Morash, Rodney H Breau
INTRODUCTION: We aimed to determine how renal tumour scoring systems, such as RENAL, PADUA, and Centrality (C)-index, compare to clinical judgement at predicting time required for tumour removal and kidney reconstruction during partial nephrectomy. METHODS: A consecutive cohort of partial nephrectomy patients treated at The Ottawa Hospital, a tertiary care uro-oncological centre, was retrospectively reviewed. Preoperative axial images were reviewed by four experienced urological oncologists who independently rated the complexity of a partial nephrectomy from 1-10 to generate a clinical judgement score...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28594672/the-experiences-of-specialist-nurses-working-within-the-uro-oncology-multidisciplinary-team-in-the-united-kingdom
#7
Geoffrey Punshon, Ruth Endacott, Phillippa Aslett, Jane Brocksom, Louisa Fleure, Felicity Howdle, Morven Masterton, Anita O'Connor, Adrian Swift, Paul Trevatt, Alison Leary
PURPOSE: United Kingdom prostate cancer nursing care is provided by a variety of urology and uro-oncology nurses. The experience of working in multidisciplinary teams (MDT) was investigated in a national study. DESIGN: The study consisted of a national survey with descriptive statistics and thematic analysis. METHODS: A secondary analysis of a data subset from a UK whole population survey was undertaken (n = 285) of the specialist nursing workforce and the services they provide...
July 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/28336286/robotic-surgery-in-uro-oncology-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
REVIEW
Daniel Steffens, Ruban Thanigasalam, Scott Leslie, Bharvi Maneck, Jane M Young, Michael Solomon
Robotic surgery represents a new horizon in minimally invasive urologic surgery. This systematic review of the literature and meta-analysis examines the effectiveness of robotic surgery compared with laparoscopic or open surgery for major uro-oncological procedures. Twenty-five articles reported findings from 8 trials of prostatectomy (4 trials) and cystectomy (4 trials) including 1033 participants. Robotic surgery is comparable with laparoscopic or open surgery for oncological outcomes and overall complications, and provides somewhat better functional outcome when compared with laparoscopic and open surgery...
August 2017: Urology
https://www.readbyqxmd.com/read/28254473/precision-surgery-and-genitourinary-cancers
#9
REVIEW
R Autorino, F Porpiglia, P Dasgupta, J Rassweiler, J W Catto, L J Hampton, E Lima, V Mirone, I H Derweesh, F M J Debruyne
The landscape of the surgical management of urologic malignancies has dramatically changed over the past 20 years. On one side, better diagnostic and prognostic tools allowed better patient selection and more reliable surgical planning. On the other hand, the implementation of minimally invasive techniques and technologies, such as robot-assisted laparoscopy surgery and image-guided surgery, allowed minimizing surgical morbidity. Ultimately, these advances have translated into a more tailored approach to the management of urologic cancer patients...
May 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28220328/the-provision-of-dietary-and-physical-activity-advice-for-men-diagnosed-with-prostate-cancer-a-qualitative-study-of-the-experiences-and-views-of-health-care-professionals-patients-and-partners
#10
Eileen Sutton, Lucy E Hackshaw-McGeagh, Jonathan Aning, Amit Bahl, Anthony Koupparis, Raj Persad, Richard M Martin, J Athene Lane
PURPOSE: To explore the views and experiences of health care professionals (HCPs), men diagnosed with localised prostate cancer and their partners about the provision of advice on diet and physical activity after diagnosis and treatment for localised prostate cancer. METHODS: Semi-structured in-depth interviews with ten HCPs (Consultant Urological Surgeons, Uro-Oncology Clinical Nurse Specialists and Allied Health Professionals: see Table 1) and sixteen men diagnosed with localised prostate cancer and seven of their partners...
April 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28035328/bladder-cancer-screening-in-lebanese-population-there-is-nothing-more-unequal-than-the-equal-treatment-of-unequal-people
#11
Mohammed Shahait, Muhammad Bulbul
Bladder cancer screening has been perplexing the uro-oncological community for the last decade. In this commentary, we ruminate on the feasibility of bladder cancer screening in our population based on epidemiological proponents.
October 27, 2016: Bladder Cancer
https://www.readbyqxmd.com/read/28005154/-pathogenesis-of-urological-complications-after-radiation-therapy
#12
Y Tolkach, G Kristiansen
Radiation therapy is a treatment modality that is often used in the uro-oncological setting. The common indication for the radiation therapy in the urological sphere is prostate cancer, whether it is used primarily as a radical approach, or postoperatively as adjuvant or salvage therapy. All urological organs are sensitive to radiation injury with the urinary bladder being the most susceptible with a typical cascade including acute and late changes, arising in the dose-dependent manner. The common indication for radiation therapy in urology is prostate cancer, which collaterally affects the urinary bladder and rarely urethra (especially the bulbo-membranous urethra)...
March 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27937057/radical-cystectomy-do-we-need-standardization
#13
REVIEW
Christian Ladurner, Evi Comploj, Emanuela Trenti, Salvatore Palermo, Alexander Pycha, Armin Pycha
The first series of radical cystectomy with a definition of surgical landmarks was published in 1949 and was characterized by a high perioperative mortality and a 5-year survival rate around 50%. Decades later, nevertheless many surgical progresses were made and the perioperative mortality dropped to 2,5%, this had not lead to an improvement of long term survival rates, also because a standardization of the procedure is still missing. Areas covered: Radical cystectomy is performed with different surgical techniques obmitting a standardization...
February 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27815086/cytoreductive-nephrectomy-in-the-tyrosine-kinase-inhibitor-era-a-question-that-may-never-be-answered
#14
EDITORIAL
Grant D Stewart, Michael Aitchison, Axel Bex, James Larkin, Claire Lawless, Arnaud Méjean, Paul Nathan, Grenville Oades, Jean-Jacques Patard, James Paul, Alain Ravaud, Bernard Escudier
Despite great interest, two randomised controlled trials (RCTs) of cytoreductive nephrectomy in the tyrosine kinase inhibitor setting in metastatic renal cell carcinoma have either closed early (SURTIME) or are recruiting very slowly (CARMENA) after 7 yr. Challenges in RCT delivery in uro-oncologic surgery are many. Multiple steps are needed to ensure strong recruitment to trials addressing important urologic cancer questions. Feasibility/pilot studies are key stepping stones towards successful delivery of surgical RCTs...
June 2017: European Urology
https://www.readbyqxmd.com/read/27738628/beyond-penile-cancer-is-there-a-role-for-sentinel-node-biopsy-in-urological-malignancies
#15
REVIEW
O R Brouwer, H G van der Poel, R F Bevers, E J van Gennep, S Horenblas
This review aims to discuss the current state-of-the-art of sentinel node (SN) mapping in urological malignancies. The principles and methodological aspects of lymphatic mapping and SN biopsy in urological malignancies are reviewed. Literature search was restricted to English language. The references of the retrieved articles were examined to identify additional articles. The review also includes meta-analyses published in the past 5 years. SN biopsy for penile cancer is recommended by the European Association of Urology as the preferred staging tool for clinically node-negative patients with at least T1G2 tumours (level of evidence 2a, Grade B)...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27681491/basic-methods-for-the-assessment-of-the-health-related-quality-of-life-in-uro-oncological-patients
#16
Roman Sosnowski, Marta Kulpa, Mariola Kosowicz, Fabrizio Presicce, Francesco Porpiglia, Andrea Tubaro, Cosimo De Nunzio, Tomasz Demkow
BACKGROUND: The evaluation of patients' expectations and quality of life in uro-oncology is considered an important outcome of treatment efficacy and satisfaction. Aim of this systematic review was to evaluate the most frequently adopted tools in uro-oncology to assess Health Related Quality of Life (HRQoL). EVIDENCE ACQUISITION: A systematic literature search until October 2015 was performed on MEDLINE, Cochrane Library, PubMed combining the following terms: "quality of life", "health related quality of life", "kidney cancer", "bladder cancer", "prostate cancer"...
September 28, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27576438/changes-in-oncological-outcomes-after-radical-nephroureterectomy-in-patients-with-upper-urinary-tract-urothelial-carcinoma-treated-in-the-last-two-decades-a-retrospective-analysis-based-on-a-multicenter-collaborative-study
#17
MULTICENTER STUDY
Makito Miyake, Yoshihiro Tatsumi, Kiyohide Fujimoto, Kazuhiro Nagao, Shigeru Sakano, Hideyasu Matsuyama, Teruo Inamoto, Haruhito Azuma, Hiroaki Yasumoto, Hiroaki Shiina
OBJECTIVE: We investigated chronological changes in the outcomes of patients with upper urinary tract urothelial carcinoma treated in the past two decades, during which there was an important change in treatment paradigm. METHODS: A retrospective review was conducted of 1180 urinary tract urothelial carcinoma patients who underwent radical nephroureterectomy in multicenter collaborative institutions between 1996 and 2015. The patients were divided into four groups according to the year when radical nephroureterectomy was performed, as follows: 1996-2000 (period 1; P1), 2001-05 (P2), 2006-10 (P3) and 2011-15 (P4)...
December 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27545448/safety-of-fondaparinux-for-prevention-of-postoperative-venous-thromboembolism-in-urological-malignancy-a-prospective-randomized-clinical-trial
#18
Kenichi Hata, Takahiro Kimura, Shunsuke Tsuzuki, Gen Ishii, Masahito Kido, Toshihiro Yamamoto, Hiroshi Sasaki, Jun Miki, Hiroki Yamada, Akira Furuta, Kenta Miki, Shin Egawa
OBJECTIVES: To prospectively evaluate the safety of postoperative fondaparinux in comparison with low molecular weight heparin in patients undergoing uro-oncological surgery. METHODS: The present study was a prospective, single-blind, non-inferiority randomized trial. A total of 359 patients undergoing surgery for urological malignancy were enrolled from January 2011 to December 2012. A total of 298 of these patients (fondaparinux group, 152; low molecular weight heparin group, 146) were evaluable for the intention-to-treat-analysis...
August 21, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27544669/enzalutamide-as-a-fourth-or-fifth-line-treatment-option-for-metastatic-castration-resistant-prostate-cancer
#19
MULTICENTER STUDY
Sushil K Badrising, Vincent van der Noort, Paul Hamberg, Jules L L M Coenen, Maureen J Aarts, Inge M van Oort, Alfons J M van den Eertwegh, Maartje Los, H Pieter van den Berg, Hans Gelderblom, Suzan Vrijaldenhoven, Emile D Kerver, Theo van Voorthuizen, Igle J de Jong, John B Haanen, Andries M Bergman
OBJECTIVE: To evaluate the efficacy of enzalutamide (Enz) as fourth- or fifth-line treatment in men with metastasized castration-resistant prostate cancer (mCRPC), by analyzing a retrospective cohort of heavily pretreated patients. METHODS: We evaluated toxicity, overall survival (OS), progression-free survival (PFS) and time to prostate-specific antigen (PSA) progression data from 47 CRPC patients treated with fourth- or fifth-line Enz. RESULTS: All patients were treated with docetaxel and abiraterone acetate and 42 patients (89%) with cabazitaxel...
2016: Oncology
https://www.readbyqxmd.com/read/27530156/nurse-led-group-consultation-intervention-reduces-depressive-symptoms-in-men-with-localised-prostate-cancer-a-cluster-randomised-controlled-trial
#20
Penelope Schofield, Karla Gough, Kerryann Lotfi-Jam, Rebecca Bergin, Anna Ugalde, Paul Dudgeon, Wallace Crellin, Kathryn Schubach, Farshard Foroudi, Keen Hun Tai, Gillian Duchesne, Rob Sanson-Fisher, Sanchia Aranda
BACKGROUND: Radiotherapy for localised prostate cancer has many known and distressing side effects. The efficacy of group interventions for reducing psychological morbidity is lacking. This study investigated the relative benefits of a group nurse-led intervention on psychological morbidity, unmet needs, treatment-related concerns and prostate cancer-specific quality of life in men receiving curative intent radiotherapy for prostate cancer. METHODS: This phase III, two-arm cluster randomised controlled trial included 331 men (consent rate: 72 %; attrition: 5 %) randomised to the intervention (n = 166) or usual care (n = 165)...
2016: BMC Cancer
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