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Uro-oncology

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https://www.readbyqxmd.com/read/27815086/cytoreductive-nephrectomy-in-the-tyrosine-kinase-inhibitor-era-a-question-that-may-never-be-answered
#1
EDITORIAL
Grant D Stewart, Michael Aitchison, Axel Bex, James Larkin, Claire Lawless, Arnaud Méjean, Paul Nathan, Grenville Oades, Jean-Jacques Patard, James Paul, Alain Ravaud, Bernard Escudier
Despite great interest, two randomised controlled trials (RCTs) of cytoreductive nephrectomy in the tyrosine kinase inhibitor setting in metastatic renal cell carcinoma have either closed early (SURTIME) or are recruiting very slowly (CARMENA) after 7 yr. Challenges in RCT delivery in uro-oncologic surgery are many. Multiple steps are needed to ensure strong recruitment to trials addressing important urologic cancer questions. Feasibility/pilot studies are key stepping stones towards successful delivery of surgical RCTs...
November 1, 2016: European Urology
https://www.readbyqxmd.com/read/27738628/beyond-penile-cancer-is-there-a-role-for-sentinel-node-biopsy-in-urological-malignancies
#2
O R Brouwer, H G van der Poel, R F Bevers, E J van Gennep, S Horenblas
This review aims to discuss the current state-of-the-art of sentinel node (SN) mapping in urological malignancies. The principles and methodological aspects of lymphatic mapping and SN biopsy in urological malignancies are reviewed. Literature search was restricted to English language. The references of the retrieved articles were examined to identify additional articles. The review also includes meta-analyses published in the past 5 years. SN biopsy for penile cancer is recommended by the European Association of Urology as the preferred staging tool for clinically node-negative patients with at least T1G2 tumours (level of evidence 2a, Grade B)...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27681491/basic-methods-for-the-assessment-of-the-health-related-quality-of-life-in-uro-oncological-patients
#3
Roman Sosnowski, Marta Kulpa, Mariola Kosowicz, Fabrizio Presicce, Francesco Porpiglia, Andrea Tubaro, Cosimo De Nunzio, Tomasz Demkow
BACKGROUND: The evaluation of patients' expectations and quality of life in uro-oncology is considered an important outcome of treatment efficacy and satisfaction. Aim of this systematic review was to evaluate the most frequently adopted tools in uro-oncology to assess Health Related Quality of Life (HRQoL). EVIDENCE ACQUISITION: A systematic literature search until October 2015 was performed on MEDLINE, Cochrane Library, PubMed combining the following terms: "quality of life", "health related quality of life", "kidney cancer", "bladder cancer", "prostate cancer"...
September 28, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27576438/changes-in-oncological-outcomes-after-radical-nephroureterectomy-in-patients-with-upper-urinary-tract-urothelial-carcinoma-treated-in-the-last-two-decades-a-retrospective-analysis-based-on-a-multicenter-collaborative-study
#4
Makito Miyake, Yoshihiro Tatsumi, Kiyohide Fujimoto, Kazuhiro Nagao, Shigeru Sakano, Hideyasu Matsuyama, Teruo Inamoto, Haruhito Azuma, Hiroaki Yasumoto, Hiroaki Shiina
OBJECTIVE: We investigated chronological changes in the outcomes of patients with upper urinary tract urothelial carcinoma treated in the past two decades, during which there was an important change in treatment paradigm. METHODS: A retrospective review was conducted of 1180 urinary tract urothelial carcinoma patients who underwent radical nephroureterectomy in multicenter collaborative institutions between 1996 and 2015. The patients were divided into four groups according to the year when radical nephroureterectomy was performed, as follows: 1996-2000 (period 1; P1), 2001-05 (P2), 2006-10 (P3) and 2011-15 (P4)...
August 30, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27545448/safety-of-fondaparinux-for-prevention-of-postoperative-venous-thromboembolism-in-urological-malignancy-a-prospective-randomized-clinical-trial
#5
Kenichi Hata, Takahiro Kimura, Shunsuke Tsuzuki, Gen Ishii, Masahito Kido, Toshihiro Yamamoto, Hiroshi Sasaki, Jun Miki, Hiroki Yamada, Akira Furuta, Kenta Miki, Shin Egawa
OBJECTIVES: To prospectively evaluate the safety of postoperative fondaparinux in comparison with low molecular weight heparin in patients undergoing uro-oncological surgery. METHODS: The present study was a prospective, single-blind, non-inferiority randomized trial. A total of 359 patients undergoing surgery for urological malignancy were enrolled from January 2011 to December 2012. A total of 298 of these patients (fondaparinux group, 152; low molecular weight heparin group, 146) were evaluable for the intention-to-treat-analysis...
August 21, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27544669/enzalutamide-as-a-fourth-or-fifth-line-treatment-option-for-metastatic-castration-resistant-prostate-cancer
#6
Sushil K Badrising, Vincent van der Noort, Paul Hamberg, Jules L L M Coenen, Maureen J Aarts, Inge M van Oort, Alfons J M van den Eertwegh, Maartje Los, H Pieter van den Berg, Hans Gelderblom, Suzan Vrijaldenhoven, Emile D Kerver, Theo van Voorthuizen, Igle J de Jong, John B Haanen, Andries M Bergman
OBJECTIVE: To evaluate the efficacy of enzalutamide (Enz) as fourth- or fifth-line treatment in men with metastasized castration-resistant prostate cancer (mCRPC), by analyzing a retrospective cohort of heavily pretreated patients. METHODS: We evaluated toxicity, overall survival (OS), progression-free survival (PFS) and time to prostate-specific antigen (PSA) progression data from 47 CRPC patients treated with fourth- or fifth-line Enz. RESULTS: All patients were treated with docetaxel and abiraterone acetate and 42 patients (89%) with cabazitaxel...
August 20, 2016: Oncology
https://www.readbyqxmd.com/read/27530156/nurse-led-group-consultation-intervention-reduces-depressive-symptoms-in-men-with-localised-prostate-cancer-a-cluster-randomised-controlled-trial
#7
Penelope Schofield, Karla Gough, Kerryann Lotfi-Jam, Rebecca Bergin, Anna Ugalde, Paul Dudgeon, Wallace Crellin, Kathryn Schubach, Farshard Foroudi, Keen Hun Tai, Gillian Duchesne, Rob Sanson-Fisher, Sanchia Aranda
BACKGROUND: Radiotherapy for localised prostate cancer has many known and distressing side effects. The efficacy of group interventions for reducing psychological morbidity is lacking. This study investigated the relative benefits of a group nurse-led intervention on psychological morbidity, unmet needs, treatment-related concerns and prostate cancer-specific quality of life in men receiving curative intent radiotherapy for prostate cancer. METHODS: This phase III, two-arm cluster randomised controlled trial included 331 men (consent rate: 72 %; attrition: 5 %) randomised to the intervention (n = 166) or usual care (n = 165)...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27474375/robot-assisted-laparoscopic-prostatectomy-versus-open-radical-retropubic-prostatectomy-early-outcomes-from-a-randomised-controlled-phase-3-study
#8
RANDOMIZED CONTROLLED TRIAL
John W Yaxley, Geoffrey D Coughlin, Suzanne K Chambers, Stefano Occhipinti, Hema Samaratunga, Leah Zajdlewicz, Nigel Dunglison, Rob Carter, Scott Williams, Diane J Payton, Joanna Perry-Keene, Martin F Lavin, Robert A Gardiner
BACKGROUND: The absence of trial data comparing robot-assisted laparoscopic prostatectomy and open radical retropubic prostatectomy is a crucial knowledge gap in uro-oncology. We aimed to compare these two approaches in terms of functional and oncological outcomes and report the early postoperative outcomes at 12 weeks. METHOD: In this randomised controlled phase 3 study, men who had newly diagnosed clinically localised prostate cancer and who had chosen surgery as their treatment approach, were able to read and speak English, had no previous history of head injury, dementia, or psychiatric illness or no other concurrent cancer, had an estimated life expectancy of 10 years or more, and were aged between 35 years and 70 years were eligible and recruited from the Royal Brisbane and Women's Hospital (Brisbane, QLD)...
September 10, 2016: Lancet
https://www.readbyqxmd.com/read/27442410/5-uro-oncology-winter-congress
#9
Momir Polenakovic, Zivko Popov
The 5th Uro-oncology Winter Congress was held in Skopje, at the Macedonian Academy of Sciences and Arts on January 30 - February 03, 2013. The Congress was co-organized by the Macedonian Academy of Sciences and Arts, the Istanbul University, the Turkish Urology Association, Macedonian Society of Urology and the Ministry of Health of the Republic of Macedonia. Topics of the Congress were tumors of urinary tract (kidney, vesica urinaria) and prostate. The latest achievements in the diagnosis and treatment of the above-mentioned disease were presented...
2015: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27364819/-what-do-prostate-cancer-patients-know-about-smoking-results-of-a%C3%A2-bicentric-questionnaire-study-kraut-study
#10
M May, C Gilfrich, P Spachmann, O Maurer, M K Dombrowski, H M Fritsche, M Wöhr, S Brookman-May, T Karl, M Schostak, M Burger, S Lebentrau
BACKGROUND: According to the results of a recent meta-analysis, cancer-specific mortality of prostate cancer (PCA) patients is enhanced by 24 % in case of a positive smoking history with a dose-dependent impact of smoking. Until now it is unknown whether this information actually reaches the patients and how extensively an informational discussion about this topic is pursued by physicians. OBJECTIVE: Three study hypotheses were defined: (1) the knowledge of PCA patients about the potential relationship between tumor progression and cigarette consumption is low, (2) only in rare cases has a clear statement been provided by treating physicians including the explicit advice to stop smoking, and (3) there was a direct association between tumor stage and the extent of cigarette consumption...
August 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27246473/-rehabilitation-of-prostate-cancer-patients-a-multidisciplinary-consensus
#11
REVIEW
Oliver Rick, J Böckmann, T Dauelsberg, W Hoffmann, W Kämpfer, U Otto, A Rogge, D Zermann
BACKGROUND: Even though several specialist groups, including the German Pension Insurance (Deutsche Rentenversicherung) and health insurance funds, participate in the rehabilitation of patients with prostate carcinoma, there is no standardized rehabilitation program available for these patients. Consequently, there is no transparency regarding the services provided within the scope of rehabilitation for the referring physicians to uro-oncological rehabilitation, in particular, neither for physicians at urological acute-care clinics, nor for the patients concerned...
July 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27222021/update-on-advances-in-molecular-pet-in-urological-oncology
#12
REVIEW
Kazuhiro Kitajima, Shingo Yamamoto, Kazuhito Fukushima, Ryogo Minamimoto, Takao Kamai, Hossein Jadvar
Integrated positron emission tomography/computed tomography (PET/CT) with 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)F-FDG) has emerged as a powerful tool for the combined metabolic and anatomic evaluation of many cancers. In urological oncology, however, the use of (18)F-FDG has been limited by a generally low tumor uptake, and physiological excretion of FDG through the urinary system. (18)F-FDG PET/CT is useful when applied to specific indications in selected patients with urological malignancy. New radiotracers and positron emission tomography/magnetic resonance imaging (PET/MRI) are expected to further improve the performance of PET in uro-oncology...
July 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27119960/-renaissance-of-immuno-oncology-for-urological-tumors-current-status
#13
M-O Grimm, Y Winkler, I Fetter, H Oppel-Heuchel
With the advent of immune checkpoint inhibitors, immunotherapy has gained new importance in oncology. Current research is focused on the cytotoxic T‑lymphocyte antigen 4 (CTLA4), programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) immune checkpoints. The CTLA4 antibody ipilimumab (melanoma) as well as the PD-1 antibodies nivolumab (melanoma, non-small cell lung cancer and renal cell carcinoma) and pembrolizumab (melanoma) are approved for the treatment of metastatic disease in Europe. Immune checkpoint inhibitors (re)activate the immune system against cancer cells and appear to be more effective than current standards for many tumors...
May 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/26977205/qualitative-twitter-analysis-of-participants-tweet-strategies-and-tweet-content-at-a-major-urologic-conference
#14
Hendrik Borgmann, Jan-Henning Woelm, Axel Merseburger, Tim Nestler, Johannes Salem, Maximilian P Brandt, Axel Haferkamp, Stacy Loeb
INTRODUCTION: The microblogging social media platform Twitter is increasingly being adopted in the urologic field. We aimed to analyze participants, tweet strategies, and tweet content of the Twitter discussion at a urologic conference. METHODS: A comprehensive analysis of the Twitter activity at the European Association of Urology Congress 2013 (#eau2013) was performed, including characteristics of user profiles, engagement and popularity measurements, characteristics and timing of tweets, and content analysis...
January 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/26961741/exercise-based-pre-habilitation-is-feasible-and-effective-in-radical-cystectomy-pathways-secondary-results-from-a-randomized-controlled-trial
#15
Bente Thoft Jensen, Sussie Laustsen, Jørgen Bjerggaard Jensen, Michael Borre, Annemette Krintel Petersen
BACKGROUND: Physical exercises offer a variety of health benefits to cancer survivors during and post-treatment. However, exercise-based pre-habilitation is not well reported in major uro-oncology surgery. The aim of this study was to investigate the feasibility, the adherence, and the efficacy of a short-term physical pre-habilitation program to patients with invasive bladder cancer awaiting radical cystectomy (RC). METHODS: A parent prospective randomized controlled clinical trial investigated efficacy of a multidisciplinary rehabilitation program on length of stay following RC...
August 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/26874654/chemotherapy-at-first-diagnosis-of-advanced-prostate-cancer-revolution-or-evolution-findings-from-a-british-uro-oncology-group-uk-survey-to-evaluate-oncologists-views-on-first-line-docetaxel-in-combination-with-androgen-deprivation-therapy-in-castrate-sensitive
#16
R Davda, S Hughes, R Jones, S J Crabb, J Troup, H Payne
AIMS: There have been three randomised trials investigating docetaxel in combination with androgen deprivation therapy as first-line therapy for hormone-sensitive metastatic and locally advanced/high-risk prostate cancer. The largest of these studies, UK STAMPEDE trial, recently presented in June 2015. The aim of this survey was to evaluate if oncologists' practice has changed as a result of these studies, or if their practice is likely to change in different clinical settings in the future...
June 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/26632846/role-of-focal-therapy-with-high-intensity-focused-ultrasound-in-the-management-of-clinically-localized-prostate-cancer
#17
REVIEW
Timur H Kuru, Julius van Essen, David Pfister, Daniel Porres
Overtreatment of prostate cancer (PC) remains one of the main burdens in uro-oncology. Focal therapy may be a reasonable alternative with less side effects and morbidity. Application of high-intensity focused ultrasound (HIFU) induces immediate and irreversible coagulation. The treatment leads to consecutive necrosis with sharply delineated margins, making HIFU a promising tool for the focal therapy of localized PC. Unlike radiation, the treatment leaves no collateral damage outside of the heated tissue, allowing repeated use of HIFU, if necessary...
2015: Oncology Research and Treatment
https://www.readbyqxmd.com/read/26553338/very-small-embryonic-like-stem-cells-vsels-detected-in-azoospermic-testicular-biopsies-of-adult-survivors-of-childhood-cancer
#18
Purna Kurkure, Maya Prasad, Vandana Dhamankar, Ganesh Bakshi
BACKGROUND: Infertility is a known side-effect of oncotherapy in cancer survivors, and often compromises the quality of life. The present study was undertaken to detect very small embryonic-like stem cells (VSELs) in testicular biopsies from young adult survivors of childhood cancer who had azoospermia. VSELs have been earlier reported in human and mouse testes. They resist busulphan treatment in mice and potentially restore spermatogenesis when the somatic niche is restored by transplanting Sertoli or mesenchymal cells...
November 9, 2015: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/26519962/-preoperative-assessment-of-patient-candidate-to-prostate-cancer-surgery
#19
REVIEW
J-B Beauval, M Mazerolles, L Salomon, M Soulié
OBJECTIVE: To determine the tools of therapeutic decision that push towards surgical treatment in non metastatic prostate cancer eligible to local treatment. The optimized assessment of the disease and eventual comorbidities improves the selection of patients. Patient's files will be presented in the uro-oncological multidisciplinary discussions to validate the customized therapeutic approach proposed. MATERIALS AND METHODS: Literature review using Medline (National library of medicine, Pubmed) and Med Science databases based on the scientific pertinence...
November 2015: Progrès en Urologie
https://www.readbyqxmd.com/read/26486818/incidence-and-risk-factors-of-venous-thromboembolism-after-pelvic-uro-oncologic-surgery-a-single-center-experience
#20
Emily C Chen, Nathan Papa, Nathan Lawrentschuk, Damien Bolton, Shomik Sengupta
OBJECTIVE: To determine the incidence and assess risk factors for the development of VTE among patients undergoing major pelvic surgery for prostate and bladder cancer in an Australian tertiary referral center. PATIENTS AND METHODS: Consecutive patients undergoing major pelvic uro-oncologic surgery, namely radical cystectomy and radical prostatectomy over a five-year period (2009-2013) were identified. Patient variables and types of thromboprophylaxis (pharmacological and/or mechanical) used in this patient cohort were collected for analyses as predictive factors...
April 2016: BJU International
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