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Sputum eosinophil

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https://www.readbyqxmd.com/read/28238403/increased-sputum-levels-of-thymus-and-activation-regulated-chemokine-in-children-with-asthma-not-eosinophilic-bronchitis
#1
M J Kim, H S Lee, I S Sol, M N Kim, J Y Hong, K E Lee, Y H Kim, K W Kim, M H Sohn, K-E Kim
BACKGROUND: Thymus and activation-regulated chemokine (TARC), a member of the CC chemokine family, plays a crucial role in Th2-specific inflammation. We aimed to determine the concentration of sputum TARC in children with asthma and eosinophilic bronchitis (EB) and its relation with eosinophilic inflammation, pulmonary function, and bronchial hyper-responsiveness. METHODS: In total, 90 children with asthma, 38 with EB, and 45 control subjects were enrolled. TARC levels were measured in sputum supernatants using an ELISA...
February 18, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28179442/t-helper-cell-type-2-th2-and-non-th2-molecular-phenotypes-of-asthma-using-sputum-transcriptomics-in-u-biopred
#2
Chih-Hsi Scott Kuo, Stelios Pavlidis, Matthew Loza, Fred Baribaud, Anthony Rowe, Iaonnis Pandis, Ana Sousa, Julie Corfield, Ratko Djukanovic, Rene Lutter, Peter J Sterk, Charles Auffray, Yike Guo, Ian M Adcock, Kian Fan Chung
Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from 104 moderate-to-severe asthmatic subjects and 16 nonasthmatic subjects.After filtering on the differentially expressed genes between eosinophil- and noneosinophil-associated sputum inflammation, we used unbiased hierarchical clustering on 508 differentially expressed genes and gene set variation analysis of specific gene sets.We defined three transcriptome-associated clusters (TACs): TAC1 (characterised by immune receptors IL33R, CCR3 and TSLPR), TAC2 (characterised by interferon-, tumour necrosis factor-α- and inflammasome-associated genes) and TAC3 (characterised by genes of metabolic pathways, ubiquitination and mitochondrial function)...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28178340/sputum-biomarkers-in-ipf-evidence-for-raised-gene-expression-and-protein-level-of-igfbp-2-il-8-and-mmp-7
#3
J Guiot, M Henket, J L Corhay, C Moermans, R Louis
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare lung disease of unknown origin leading rapidly to death. This paper addresses the issue of whether sputum induction is a suitable tool to study respiratory tract inflammation and potential biomarkers in IPF compared to COPD, a fibrosing airway wall disease. METHODS: In a cross-sectional analysis, 15 IPF patients, 32 COPD and 30 healthy subjects underwent sputum induction. Total sputum cell counts and the amount of TGF- β, IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, IL-8, IL-13, MMP-7, MMP-9, YKL-40, TNF-α and KL-6 in sputum supernatant were analysed...
2017: PloS One
https://www.readbyqxmd.com/read/28161533/prevalence-determinants-and-clinical-correlates-of-vitamin-d-deficiency-in-patients-with-chronic-obstructive-pulmonary-disease-in-london-uk
#4
David A Jolliffe, Wai Yee James, Richard L Hooper, Neil C Barnes, Claire L Greiller, Kamrul Islam, Angshu Bhowmik, Peter M Timms, Raj K Rajakulasingam, Aklak B Choudhury, David E Simcock, Elina Hyppönen, Robert T Walton, Christopher J Corrigan, Christopher J Griffiths, Adrian R Martineau
Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with this condition is lacking. We conducted a multi-centre cross-sectional study in 278 COPD patients aged 41-92 years in London, UK. Details of potential environmental determinants of vitamin D status and COPD symptom control and severity were collected by questionnaire, and blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction...
February 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28154802/the-transition-of-sputum-inflammatory-cell-profiles-is-variable-in-stable-asthma-patients
#5
Bomi Shin, Hyouk-Soo Kwon, So Young Park, Tae-Bum Kim, Hee-Bom Moon, You Sook Cho
BACKGROUND: The sputum inflammatory cell profile is an important indicator for classifying asthma phenotypes. OBJECTIVE: To investigate if sputum inflammatory cell profile remains stable and there are different characteristics between groups that show different profile over time in stable asthmatic patients. METHODS: A total of 149 asthmatic patients, who were clinically stable at the time of sputum examination and had undergone sputum analysis twice, were subjected to a detailed review...
January 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28145647/relationship-between-fractional-exhaled-nitric-oxide-level-and-efficacy-of-inhaled-corticosteroid-in-asthma-copd-overlap-syndrome-patients-with-different-disease-severity
#6
Jia Xi Feng, Yun Lin, Jian Lin, Su Su He, Mei Fang Chen, Xiao Mai Wu, You Zu Xu
This study explored the relationship between the fractional exhaled nitric oxide (FeNO) level and the efficacy of inhaled corticosteroid (ICS) in asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) patients with different disease severity. A total of 127 ACOS patients with ACOS (case group) and 131 healthy people (control group) were enrolled in this study. Based on the severity of COPD, the ACOS patients were divided into: mild ACOS; moderate ACOS; severe ACOS; and extremely severe ACOS groups...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28137494/characteristics-associated-with-clinical-severity-and-inflammatory-phenotype-of-naturally-occurring-virus-induced-exacerbations-of-asthma-in-adults
#7
Asger Bjerregaard, Ingrid A Laing, Nadia Poulsen, Vibeke Backer, Asger Sverrild, Markus Fally, Siew-Kim Khoo, Lucy Barrett, Svetlana Baltic, Philip J Thompson, Glenys Chidlow, Chisha Sikazwe, David W Smith, Yury A Bochkov, Peter Le Souëf, Celeste Porsbjerg
BACKGROUND: In experimental studies viral infections have been shown to induce type 2 inflammation in asthmatics, but whether this is a feature of naturally occurring virus-induced asthma exacerbations is unknown. Thymic stromal lymphopoietin (TSLP) released from the airway epithelium in response to damage, has been suggested as a link between viral infection and type 2 inflammation, but the role of TSLP in asthma exacerbations is unknown. OBJECTIVE: To assess whether type 2 inflammation, as measured by sputum eosinophils and fractional exhaled nitric oxide (FeNO), is a feature of naturally occurring virus-induced exacerbations of asthma and whether TSLP is associated with this type 2 inflammation...
February 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28070196/airway-autoimmune-responses-in-severe-eosinophilic-asthma-following-low-dose-mepolizumab-therapy
#8
Manali Mukherjee, Hui Fang Lim, Sruthi Thomas, Douglas Miller, Melanie Kjarsgaard, Bruce Tan, Roma Sehmi, Nader Khalidi, Parameswaran Nair
BACKGROUND: Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for severe eosinophilic asthma. CASE PRESENTATION: A 62-year old woman diagnosed with severe eosinophilic asthma showed poor response to Mepolizumab therapy (100 mg subcutaneous dose/monthly) and subsequent worsening of symptoms. The treatment response to Mepolizumab was monitored using both blood and sputum eosinophil counts...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28069248/race-is-associated-with-differences-in-airway-inflammation-in-patients-with-asthma
#9
Sharmilee M Nyenhuis, Jerry A Krishnan, Alalia Berry, William J Calhoun, Vernon M Chinchilli, Linda Engle, Nicole Grossman, Fernando Holguin, Elliot Israel, Rick A Kittles, Monica Kraft, Stephen C Lazarus, Erik B Lehman, David T Mauger, James N Moy, Stephen P Peters, Wanda Phipatanakul, Lewis J Smith, Kaharu Sumino, Stanley J Szefler, Michael E Wechsler, Sally Wenzel, Steven R White, Steven J Ackerman
BACKGROUND: African American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between African American and white subjects is unclear. OBJECTIVE: We sought to compare sputum airway inflammatory phenotypes of African American and white subjects treated or not with inhaled corticosteroids (ICSs; ICS+ and ICS-, respectively). METHODS: We performed a secondary analysis of self-identified African American and white subjects with asthma enrolled in clinical trials conducted by the National Heart, Lung, and Blood Institute-sponsored Asthma Clinical Research Network and AsthmaNet...
December 31, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28042058/eosinophilic-airway-inflammation-in-asthma-is-associated-with-an-altered-airway-microbiome
#10
Asger Sverrild, Pia Kiilerich, Asker Brejnrod, Rebecca Pedersen, Celeste Porsbjerg, Anders Bergqvist, Jonas S Erjefält, Karsten Kristiansen, Vibeke Backer
BACKGROUND: Subjects with asthma have higher microbiome diversity, and an altered composition with more Proteobacteria and less Bacteroidetes compared to healthy controls. Studies comparing airway inflammation and airway microbiome are sparse, especially in subjects not on anti-inflammatory treatment. OBJECTIVE: To describe the relationship between the airway microbiome and patterns of airway inflammation in steroid-free subjects with asthma and healthy controls...
December 29, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28036144/revisiting-type-2-high-and-type-2-low-airway-inflammation-in-asthma-current-knowledge-and-therapeutic-implications
#11
REVIEW
D Robinson, M Humbert, R Buhl, A A Cruz, H Inoue, S Korom, N A Hanania, P Nair
Asthma is a complex respiratory disorder characterized by marked heterogeneity in individual patient disease triggers and response to therapy. Several asthma phenotypes have now been identified, each defined by a unique interaction between genetic and environmental factors, including inflammatory, clinical and trigger-related phenotypes. Endotypes further describe the functional or pathophysiologic mechanisms underlying the patient's disease. type 2-driven asthma is an emerging nomenclature for a common subtype of asthma and is characterized by the release of signature cytokines IL-4, IL-5 and IL-13 from cells of both the innate and adaptive immune systems...
February 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28029801/sinus-computed-tomographic-findings-in-adult-smoking-and-non-smoking-asthmatics-analysis-of-clinical-indices-and-biomarkers
#12
Hirokazu Kimura, Satoshi Konno, Yuji Nakamaru, Hironi Makita, Natsuko Taniguchi, Kaoruko Shimizu, Masaru Suzuki, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Masaharu Nishimura
RATIONALE: When the two conditions occur together, sinusitis and asthma are often thought to represent anatomically separate components of the same chronic inflammatory airway disease. Information about the effect of smoking on the interaction between sinusitis and asthma in patients who have both disorders is limited. OBJECTIVES: This study aimed to evaluate the effect of cigarette smoking on the relationship between the presence and severity of sinusitis and selected asthma-related indices in adults who have asthma...
December 28, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28029172/diagnosing-eosinophilic-asthma-using-a-multivariate-prediction-model-based-on-blood-granulocyte-responsiveness
#13
B Hilvering, S J H Vijverberg, J Jansen, L Houben, R C Schweizer, S Go, L Xue, I D Pavord, J-W J Lammers, L Koenderman
BACKGROUND: The identification of inflammatory asthma phenotypes, using sputum analysis, has proven its value in diagnosis and disease monitoring. However due to technical limitations of sputum analysis there is a strong need for fast and non-invasive diagnostics. This study included the activation state of eosinophils and neutrophils in peripheral blood to phenotype and monitor asthma. OBJECTIVES: To (1) construct a multivariable model using the activation state of blood granulocytes, (2) compare its diagnostic value with sputum eosinophilia as gold standard and (3) validate the model in an independent patient cohort...
December 28, 2016: Allergy
https://www.readbyqxmd.com/read/28007353/impact-of-obstructive-sleep-apnea-on-severe-asthma-exacerbations
#14
Yeya Wang, Kun Liu, Ke Hu, Jun Yang, Ze Li, Meiling Nie, Yan Dong, Hanlin Huang, Junwen Chen
BACKGROUND: Patients with asthma have a higher incidence of obstructive sleep apnea (OSA). However, the association between OSA and the exacerbation of severe asthma remains unclear. In this study, we aimed to investigate the prevalence of OSA in a cross-sectional study of asthma patients and to prospectively examine the significance of the effect of OSA on severe asthma exacerbations. METHODS: One hundred and forty-six patients with asthma and 157 matched-controlled individuals were enrolled in this study...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28002338/sputum-pentraxin-3-as-a-candidate-to-assess-airway-inflammation-and-remodeling-in-childhood-asthma
#15
Min Jung Kim, Hee Seon Lee, In Suk Sol, Mi Na Kim, Jung Yeon Hong, Kyung Eun Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor and an acute-phase protein. It has gained attention as a new biomarker reflecting tissue inflammation and damage in a variety of diseases. Aim of this study is to investigate the role of PTX3 in childhood asthma.In total, 260 children (140 patients with asthma and 120 controls) were enrolled. PTX3 levels were measured in sputum supernatants using enzyme-linked immunosorbent assay test. We performed spirometry and methacholine challenge tests and measured the total eosinophil count and the serum levels of total IgE and eosinophil cationic protein (ECP) in all subjects...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27994925/acute-eosinophilic-pneumonia-with-respiratory-failure-induced-by-synthetic-cannabinoid-inhalation
#16
Nesrin Öcal, Deniz Doğan, Ali Fuat Çiçek, Orhan Yücel, Ergun Tozkoparan
BACKGROUND: In recent days, synthetic cannabinoid derivatives have become life threatening for young people. Here, we want to share a case of acute eosinophilic pneumonia triggered by inhalation of synthetic cannabinoid, new side effects of which are being detected day by day. CASE REPORT: A 21-year-old male, who had no history of pulmonary diseases, was admitted to the clinic with shortness of breath. His oxygen saturation was measured as 85-86% in room air. Common irregular ground-glass opacities were observed in thorax radiology...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27993536/neutrophils-are-a-major-source-of-the-epithelial-barrier-disrupting-cytokine-oncostatin-m-in-patients-with-mucosal-airways-disease
#17
Kathryn L Pothoven, James E Norton, Lydia A Suh, Roderick G Carter, Kathleen E Harris, Assel Biyasheva, Kevin Welch, Stephanie Shintani-Smith, David B Conley, Mark C Liu, Atsushi Kato, Pedro C Avila, Qutayba Hamid, Leslie C Grammer, Anju T Peters, Robert C Kern, Bruce K Tan, Robert P Schleimer
BACKGROUND: We have previously shown that oncostatin M (OSM) levels are increased in nasal polyps (NPs) of patients with chronic rhinosinusitis (CRS), as well as in bronchoalveolar lavage fluid, after segmental allergen challenge in allergic asthmatic patients. We also showed in vitro that physiologic levels of OSM impair barrier function in differentiated airway epithelium. OBJECTIVE: We sought to determine which hematopoietic or resident cell type or types were the source of the OSM expressed in patients with mucosal airways disease...
December 18, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27983888/eosinophilic-and-neutrophilic-airway-inflammation-in-the-phenotyping-of-mild-to-moderate-asthma-and-chronic-obstructive-pulmonary-disease
#18
Katarzyna Górska, Magdalena Paplińska-Goryca, Patrycja Nejman-Gryz, Krzysztof Goryca, Rafał Krenke
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with different inflammatory phenotypes. Various inflammatory mediators play a role in these diseases. The aim of this study was to analyze the neutrophilic and eosinophilic airway and systemic inflammation as the phenotypic characterization of patients with asthma and COPD. Twenty-four patients with asthma and 33 patients with COPD were enrolled in the study. All the patients were in mild-to-moderate stage of disease, and none of them were treated with inhaled corticosteroids...
December 16, 2016: COPD
https://www.readbyqxmd.com/read/27965774/cxc-chemokine-superfamily-induced-by-interferon-%C3%AE-in-asthma-a-cross-sectional-observational-study
#19
Yotaro Takaku, Tomoyuki Soma, Yoshitaka Uchida, Takehito Kobayashi, Kazuyuki Nakagome, Makoto Nagata
BACKGROUND: Asthma is a disease encompassing a variety of contributing factors. Phenotyping of asthma based on the profile of accumulated granulocytes in the airways has been performed to explore the mediators involved in allergic bronchial inflammation. The aim of this study was to clarify the characteristics of the CXC chemokine superfamily induced by IFN-γ, namely CXCR3 ligands, in the airways of patients with asthma stratified by the differential proportion of granulocytes in sputum...
2016: Asthma research and practice
https://www.readbyqxmd.com/read/27942431/biomarkers-for-the-phenotyping-and-monitoring-of-asthma-in-children
#20
REVIEW
Anna James, Gunilla Hedlin
An important issue in relation to the utility and reliability of biomarkers for asthma monitoring is how asthma is defined and characterized. What kind of asthma, or at what stage of the disease is a particular biomarker supposed to add information? Often, the purpose, or usefulness of a biomarker is not made clear. Diagnosis, severity evaluation, and monitoring are all different clinical uses for a biomarker, and confusion may arise when a biomarker is suitable for one of these but not another. When the utility of available biomarkers are discussed, these different roles need to be clarified...
2016: Current Treatment Options in Allergy
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