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Sputum eosinophil

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https://www.readbyqxmd.com/read/29337345/sputum-cytology-during-late-phase-responses-to-inhalation-challenge-with-different-allergens
#1
Joana A Revez, Kieran J Killian, Paul M O'Byrne, Louis-Philippe Boulet, John W Upham, Gail M Gauvreau, Manuel A R Ferreira
BACKGROUND: In mouse models of allergic asthma, exposure to different allergens can trigger distinct inflammatory subtypes in the airways. We investigated if this observation extends to humans. METHODS: We compared the frequency of sputum inflammatory subtypes between mild allergic asthma subjects (n=129) exposed to different allergens in inhalation challenge tests. These tests were performed using a standardized protocol as part of clinical trials of experimental treatments for asthma, prior to drug randomization...
January 16, 2018: Allergy
https://www.readbyqxmd.com/read/29317659/clinical-outcome-of-eosinophilic-airway-inflammation-in-chronic-airway-diseases-including-nonasthmatic-eosinophilic-bronchitis
#2
Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Chang-Hoon Lee
We enrolled patients with confirmed sputum eosinophilia who had visited our tertiary referral hospital between 2012 and 2015. We evaluated the incidence and predictors of exacerbations in patients with nonasthmatic eosinophilic bronchitis (NAEB), and investigated predictors of improvement in eosinophilic inflammation in chronic airway diseases with or without persistent airflow limitation. In total, 398 patients with sputum eosinophilia were enrolled. Of these, 152 (38.2%) had NAEB. The incidence rate of exacerbations requiring treatment with antibiotics, systemic corticosteroids, or hospital admission was 0...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313707/sputum-eosinophilia-and-mri-ventilation-heterogeneity-in-severe-asthma
#3
Sarah Svenningsen, Rachel L Eddy, Hui Fang Lim, P Gerard Cox, Parameswaran Nair, Grace Parraga
RATIONALE: Inflammation and smooth muscle dysfunction are integral components of severe asthma that contribute to luminal obstruction causing airflow limitation, ventilation heterogeneity and symptoms. This is important for guiding treatment decisions directed at inflammatory (eg. anti-Th2 monoclonal antibodies) and non-inflammatory, smooth muscle-mediated (eg. bronchial thermoplasty) components of severe asthma. OBJECTIVE: To investigate the contribution of eosinophilic-bronchitis and smooth muscle dysfunction to magnetic-resonance-imaging (MRI) ventilation heterogeneity in severe asthmatics...
January 9, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29301585/a-randomised-pragmatic-trial-of-corticosteroid-optimization-in-severe-asthma-using-a-composite-biomarker-algorithm-to-adjust-corticosteroid-dose-versus-standard-care-study-protocol-for-a-randomised-trial
#4
Catherine E Hanratty, John G Matthews, Joseph R Arron, David F Choy, Ian D Pavord, P Bradding, Christopher E Brightling, Rekha Chaudhuri, Douglas C Cowan, Ratko Djukanovic, Nicola Gallagher, Stephen J Fowler, Tim C Hardman, Tim Harrison, Cécile T Holweg, Peter H Howarth, James Lordan, Adel H Mansur, Andrew Menzies-Gow, Sofia Mosesova, Robert M Niven, Douglas S Robinson, Dominick E Shaw, Samantha Walker, Ashley Woodcock, Liam G Heaney
BACKGROUND: Patients with difficult-to-control asthma consume 50-60% of healthcare costs attributed to asthma and cost approximately five-times more than patients with mild stable disease. Recent evidence demonstrates that not all patients with asthma have a typical type 2 (T2)-driven eosinophilic inflammation. These asthmatics have been called 'T2-low asthma' and have a minimal response to corticosteroid therapy. Adjustment of corticosteroid treatment using sputum eosinophil counts from induced sputum has demonstrated reduced severe exacerbation rates and optimized corticosteroid dose...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29284904/blood-count-of-eosinophil-polymorphonuclear-leucocytes-and-bronchial-hyperreactivity-in-chronic-obstructive-pulmonary-disease
#5
Vesna Cukic
Introduction: Polymorphonuclear eosinophil leucocytes (eosinophils) are found in increased numbers in the circulation and sputum in asthma patients, usually in relation to the severity of asthma but it is the question whether they have a significant role in the development and level of bronchial hyperreactivity in patients with chronic obstructive pulmonary disease (COPD). Objective: to show the role of the eosinophils in the development and level of BHR in patients with COPD and so in the severity of illness...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29240514/menopausal-asthma-much-ado-about-nothing-an-observational-study
#6
Katarzyna Bialek-Gosk, Marta Maskey-Warzechowska, Rafal Krenke, Marta Dabrowska, Magdalena Paplinska-Goryca, Patrycja Nejman-Gryz, Joanna Domagala-Kulawik, Tadeusz Przybylowski, Ryszarda Chazan
OBJECTIVE: Menopausal asthma is considered a distinct asthma phenotype. Our aim was to identify potential specific features of asthma in postmenopausal women in a cohort of Polish females. METHODS: Asthma severity and control, pulmonary function, exhaled nitric oxide (FENO), peripheral blood and induced sputum (IS) differential cell count were compared in three groups: women with premenopausal asthma (group 1), menopausal women with pre-existing asthma (group 2A) and menopausal women with asthma onset in the perimenopausal or menopausal period (group 2B)...
December 14, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29227262/-combined-course-of-bronchial-asthma-and-gastroesophageal-reflux-disease-its-clinical-functional-peculiarities-and-mechanisms-of-its-correction
#7
M Derbak, O Boldizhar, Ye Sirchak, Ya Lazur, M Aleksandrova
The combined course of bronchial asthma (BA) and digestive system pathology is one of the most frequent, severe and clinically varied pathology. The purpose of the paper - to study the influence of gastroesophageal reflux disease (GERD) on the course of BA and the effectiveness of antireflux therapy in combined pathology. Patients with combined pathology were treated in full-time department more frequently than patients with isolated BA (3,4±0,5 per year to - 1,8±0,3; р<0,05). The statistically reliable correlation between frequency of heartburn and frequency of cough, which goes over to asthma attacks was observed (r=0,59; р<0,05)...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29221918/low-variability-in-peak-expiratory-flow-predicts-successful-inhaled-corticosteroid-step-down-in-adults-with-asthma
#8
Naomi Tsurikisawa, Chiyako Oshikata, Toshio Sato, Goro Kimura, Masami Mizuki, Takahiro Tsuburai, Shunsuke Shoji, Hiroshi Saito, Terufumi Shimoda
BACKGROUND: The prognosis for patients beyond 1 year after reduction of their inhaled corticosteroid (ICS) dose remains unknown. Predictive factors that can be evaluated before the initiation of asthma treatment or at ICS dose reduction are unknown. METHODS: We prospectively studied 223 patients in 6 hospitals in the National Hospital Organization of Japan during the 36 months after 50% reduction of their daily ICS dose. All patients recorded their morning and evening peak expiratory flows (PEFs) in their diaries...
December 5, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29221581/biomarkers-for-severe-eosinophilic-asthma
#9
REVIEW
Steven W Yancey, Oliver N Keene, Frank C Albers, Hector Ortega, Stewart Bates, Eugene R Bleecker, Ian Pavord
The last decade has seen the approval of several new biologics for the treatment of severe asthma-targeting specific endotypes and phenotypes. This review will examine how evidence generated from the mepolizumab clinical development program showed that blood eosinophil counts, rather than sputum or tissue eosinophil counts, evolved as a pharmacodynamic and predictive biomarker for the efficacy of treatment with mepolizumab in patients with severe eosinophilic asthma. Based on the available evidence and combined with clinical judgement, a baseline blood eosinophil threshold of 150 cells/μL or greater or a historical blood eosinophil threshold of 300 cells/μL or greater will allow selection of patients with severe eosinophilic asthma who are most likely to achieve clinically significant reductions in the rate of exacerbations with mepolizumab treatment...
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29202821/effects-of-treatment-changes-on-asthma-phenotype-prevalence-and-airway-neutrophil-function
#10
Collin R Brooks, Christine J Van Dalen, Elizabeth Harding, Ian F Hermans, Jeroen Douwes
BACKGROUND: Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthma phenotypes and airway neutrophil function. The purpose of this study was to assess asthma phenotype prevalence/characteristics in a community setting, and, in a nested preliminary study, determine how treatment changes affect phenotype stability and inflammation, with particular focus on airway neutrophils...
December 4, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29200843/eosinophilic-and-non-eosinophilic-copd-patients-with-chronic-respiratory-failure-neutrophil-to-lymphocyte-ratio-as-an-exacerbation-marker
#11
Eylem Acartürk Tunçay, Zuhal Karakurt, Emine Aksoy, Cuneyt Saltürk, Sinem Gungor, Nezihe Ciftaslan, İlim Irmak, Dilek Yavuz, Birsen Ocakli, Nalan Adıgüzel
Aim: Increased dyspnea, sputum volume, and purulence are subjective symptoms in COPD patients. To diagnose COPD exacerbations with chronic respiratory failure (CRF) and to assess the requirement for antibiotic treatment, physicians require more objective criteria. We aimed to investigate whether neutrophil-to-lymphocyte ratio (NLR) can be used as an infectious exacerbation marker in COPD patients with CRF. Patients and methods: This retrospective cross-sectional study was performed in the intensive care outpatient clinic of a tertiary training hospital between 2014 and 2015...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29183929/effectiveness-of-inhaled-corticosteroids-in-real-life-on-clinical-outcomes-sputum-cells-and-systemic-inflammation-in-asthmatics-a-retrospective-cohort-study-in-a-secondary-care-centre
#12
Sophie F Demarche, Florence N Schleich, Monique A Henket, Virginie A Paulus, Thierry J Van Hees, Renaud E Louis
OBJECTIVES: The impact of inhaled corticosteroids (ICS) on eosinophilic inflammation in asthma is well established, but their effect in a real-life setting has not been extensively studied. Our purpose was to investigate the effect of ICS on airway and systemic inflammation as well as on clinical outcomes in patients with asthma from clinical practice. DESIGN, SETTING AND PARTICIPANTS: We conducted a retrospective analysis on asthmatics from a secondary care centre in whom ICS were initiated/increased (n=101), stopped/decreased (n=60) or remained stable (n=63, used as a control group) between two visits with available sputum and blood cell counts...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29177539/does-feno-predict-clinical-characteristics-in-chronic-cough
#13
Mahboobeh Haji Sadeghi, Caroline E Wright, Simon Hart, Michael Crooks, Alyn H Morice
PURPOSE: To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype. METHODS: We have studied consecutive patients attending a specialist cough clinic. 30 patients with high FeNO (> 30 ppb) and 20 patients with low FeNO (< 20 ppb) were recruited. RESULTS: There was a significant correlation between FeNO, B-Eos and sputum eosinophil count (p < 0...
November 25, 2017: Lung
https://www.readbyqxmd.com/read/29176061/exhaled-breath-temperature-in-optimally-treated-asthmatics-severity-and-underlying-mechanisms
#14
Polyxeni Ntontsi, Petros Bakakos, Evgenia Papathanasiou, Zoi Tsilogianni, Konstantinos Kostikas, Georgios Hillas, Georgios Papatheodorou, Nikolaos G Koulouris, Spyridon Papiris, Stelios Loukides
ABSTRACT Introduction: Increased vascularity may lead to loss of heat in the airways and may modulate Exhaled breath temperature (EBT). Increased EBT has been associated with uncontrolled asthma. Aim: We wanted to determine whether the measurement of EBT in optimally treated asthmatic patients is influenced by the increased vascular permeability and whether Vascular endothelial growth factor (VEGF) is implicated in the above process. Furthermore, to assess the impact of asthma severity on EBT values...
November 27, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29154772/endogenous-peroxidases-in-sputum-interfere-with-horse-radish-peroxidase-based-elisas
#15
Lisa Ha-Yeon Kim, Karin Plaza, Sruthi R Thomas, Christina Draijer, Katherine Radford, Marc Peters-Golden, Manali Mukherjee, Parameswaran Nair
Peroxidase-based immunoassays are commonly used for detecting inflammatory mediators in biological samples. We suggest caution while interpreting assays particularly in sputum samples that have endogenous peroxidases like eosinophil peroxidase (EPX), which may interact with a horseradish peroxidase (HRP)-based ELISA. Using IL-8 as an example, we demonstrate that values generated with an HRP-ELISA (n=47) show significant positive correlation with the sputum EPX content (r=0.6, P=0.0004), which can be misconstrued to be affiliated with an eosinophilic event...
November 14, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29150070/decreased-expression-of-indolamine-2-3-dioxygenase-in-childhood-allergic-asthma-and-its-inverse-correlation-with-fractional-concentration-of-exhaled-nitric-oxide
#16
Ying Hu, Zhiqiang Chen, Ling Jin, Mei Wang, Wei Liao
BACKGROUND: The tryptophan metabolic pathway mediated by indolamine 2,3-dioxygenase (IDO), a tryptophan-degrading enzyme, plays an important role in controlling the development of allergic inflammation. The fractional concentration of exhaled nitric oxide (FeNO) is closely associated with the allergic state and is extensively used for the clinical evaluation of airway allergic inflammation. Clinical trials have rarely assessed the expression of IDO in childhood allergic asthma and its correlation with FeNO...
November 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29146301/association-of-sputum-and-blood-eosinophil-concentrations-with-clinical-measures-of-copd-severity-an-analysis-of-the-spiromics-cohort
#17
Annette T Hastie, Fernando J Martinez, Jeffrey L Curtis, Claire M Doerschuk, Nadia N Hansel, Stephanie Christenson, Nirupama Putcha, Victor E Ortega, Xingnan Li, R Graham Barr, Elizabeth E Carretta, David J Couper, Christopher B Cooper, Eric A Hoffman, Richard E Kanner, Eric Kleerup, Wanda K O'Neal, Richard Paine, Stephen P Peters, Neil E Alexis, Prescott G Woodruff, MeiLan K Han, Deborah A Meyers, Eugene R Bleecker
BACKGROUND: Increased concentrations of eosinophils in blood and sputum in chronic obstructive pulmonary disease (COPD) have been associated with increased frequency of exacerbations, reduced lung function, and corticosteroid responsiveness. We aimed to assess whether high eosinophil concentrations in either sputum or blood are associated with a severe COPD phenotype, including greater exacerbation frequency, and whether blood eosinophils are predictive of sputum eosinophils. METHODS: We did a multicentre observational study analysing comprehensive baseline data from SPIROMICS in patients with COPD aged 40-80 years who had a smoking history of at least 20 pack-years, recruited from six clinical sites and additional subsites in the USA between Nov 12, 2010, and April 21, 2015...
December 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29137638/virus-triggered-exacerbation-in-allergic-asthmatic-children-neutrophilic-airway-inflammation-and-alteration-of-virus-sensors-characterize-a-subgroup-of-patients
#18
Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq, Philippe Gosset
BACKGROUND: Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsible for this defect remain unclear. The objective of this study was to compare in virus-infected and not-infected allergic asthmatic children, aged 6 to 16 years, admitted to hospital for a severe exacerbation, the innate immune response and especially the expression of pattern recognition receptor (PRR) and their function...
November 14, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29103994/sputum-cell-interleukin-1-receptor-expression-level-is-a-marker-of-airway-neutrophilia-and-airflow-obstruction-in-asthma
#19
Michael D Evans, Stephane Esnault, Loren C Denlinger, Nizar N Jarjour
BACKGROUND: Various clinical, biologic or physiologic markers of asthma have been used to identify patient clusters and potential targets for therapy. However, these identifiers frequently overlap among the different asthma groups. For instance, both eosinophils and neutrophils are often increased in the airway of asthma patients despite their typical association with type-2 and type-17 immune response, respectively. OBJECTIVES: To determine whether inflammatory gene expressions are related to patterns of airway inflammation and lung function, and identify molecular markers for neutrophilic asthma...
November 2, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29099646/emphysematous-phenotype-is-characterized-by-low-blood-eosinophils-a-cross-sectional-study
#20
Andriana I Papaioannou, Konstantinos Kostikas, Anastasia Papaporfyriou, Leonidas Angelakis, Evgenia Papathanasiou, Georgios Hillas, Argyro Mazioti, Petros Bakakos, Nikolaos Koulouris, Spyros Papiris, Stelios Loukides
Sputum and blood eosinophils are proposed as candidate biomarkers for the identification of chronic obstructive pulmonary disease (COPD) patients at risk for exacerbation and treatment response. In this study, we evaluated the associations of eosinophils with the presence of emphysema in COPD patients. Induced sputum and blood eosinophil measurements were performed in consecutive COPD patients. Patients underwent lung function testing and high resolution computed tomography (HRCT) of the chest and the presence of emphysema was quantified...
December 2017: COPD
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