keyword
https://read.qxmd.com/read/38536949/combination-nano-delivery-systems-remodel-the-immunosuppressive-tumor-microenvironment-for-metastatic-triple-negative-breast-cancer-therapy
#1
JOURNAL ARTICLE
Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer for which effective therapies are lacking. Targeted remodeling of the immunosuppressive tumor microenvironment (TME) and activation of the body's immune system to fight tumors with well-designed nanoparticles have emerged as pivotal breakthroughs in tumor treatment. To simultaneously remodel the immunosuppressive TME and trigger immune responses, we designed two potential therapeutic nanodelivery systems to inhibit TNBC. First, the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 and the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CXB) were coloaded into chondroitin sulfate (CS) to obtain CS@JQ1/CXB nanoparticles (NPs)...
March 27, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38536853/halofuginone-prevents-outer-retinal-degeneration-in-a-mouse-model-of-light-induced-retinopathy
#2
JOURNAL ARTICLE
Yukihiro Miwa, Deokho Lee, Chiho Shoda, Heonuk Jeong, Kazuno Negishi, Toshihide Kurihara
Photoreceptor cell death can cause progressive and irreversible visual impairments. Still, effective therapies on retinal neuroprotection are not available. Hypoxia-inducible factors (HIFs) are transcriptional factors which strongly regulate angiogenesis, erythropoiesis, intracellular metabolism, and programed cell death under a hypoxic or an abnormal metabolic oxidative stress condition. Therefore, we aimed to unravel that inhibition of HIFs could prevent disease progression in photoreceptor cell death, as recent studies showed that HIFs might be pathologic factors in retinal diseases...
2024: PloS One
https://read.qxmd.com/read/38536827/effects-of-aflibercept-and-bevacizumab-on-cell-viability-cell-metabolism-and-inflammation-in-hypoxic-human-m%C3%A3-ller-cells
#3
JOURNAL ARTICLE
Monique Matsuda, Rafael André da Silva, Vinicius Moraes de Paiva Roda, Mônica Valéria Marquezini, Mário Luiz Ribeiro Monteiro, Dânia Emi Hamassaki
Anti-VEGF (vascular endothelial growth factor) drugs such as aflibercept (AFL) and bevacizumab (BVZ) inhibit pathological neo-angiogenesis and vascular permeability in retinal vascular diseases. As cytokines and growth factors are produced by Müller glial cells under stressful and pathological conditions, we evaluated the in vitro effect of AFL (Eylea®, 0.5 mg/mL) and BVZ (Avastin®, 0.5 mg/mL) on cell viability/metabolism, and cytokine/growth factor production by Müller cells (MIO-M1) under cobalt chloride (CoCl2)-induced hypoxia after 24h, 48h and 72h...
2024: PloS One
https://read.qxmd.com/read/38536591/circ_0020460-drives-tumorigenesis-in-cervical-cancer-through-mir-485-3p-sponging
#4
JOURNAL ARTICLE
Kun Yan, Chunyan Hu, Yali Cheng, Lingzhi Zheng, Baojin Zeng, Sujun Zhao, Chen Liu
Deregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the role of circ_0020460 in the development of cervical cancer (CC) and its potential mechanism of action. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were used to detect the expression levels of circ_0020460, miR-485-3p and C-X-C motif chemokine ligand 1 (CXCL1). The roles of circ_0020460 on cell proliferation, cell migration, cell invasion, cell apoptosis, and angiogenesis were investigated using cell counting kit-8 (CCK-8) and Ethynyl deoxyuridine (Edu) assay, wound healing assay, transwell assay, flow cytometry assay, and tube formation assay, respectively...
March 27, 2024: Discover. Oncology
https://read.qxmd.com/read/38536106/effects-of-photobiomodulation-therapy-on-the-expression-of-hypoxic-inducible-factor-vascular-endothelial-growth-factor-and-its-specific-receptor-a-randomized-control-trial-in-patients-with-diabetic-foot-ulcer
#5
JOURNAL ARTICLE
Giti Torkaman, Mahsa Hoseini-Sanati, Mehdi Hedayati, Maryam Mofid, Manouchehr Iranparvar Alamdari
Background: Impaired angiogenesis is a significant factor contributing to delayed healing in diabetic foot ulcers (DFUs) due to inadequate oxygenation. Objective: This study aimed to investigate the impact of photobiomodulation (PBM) using a Ga-As laser on the release of serum hypoxia-inducible factor 1-α (HIF-1α), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2, and nitric oxide (NO) in diabetic patients with DFUs. Materials and methods: In this double-blind RCT, a total of 30 patients with grade II DFUs were enrolled...
March 27, 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38535834/hepatic-gene-expression-of-angiogenic-and-regeneration-markers-in-cats-with-congenital-portosystemic-shunts-cpss
#6
JOURNAL ARTICLE
Michael S Tivers, Samantha M Mirczuk, Abigail Charlesworth, Lauren Wood, Emi N Barker, Victoria J Lipscomb, Robert C Fowkes
Congenital portosystemic shunts (CPSS) are vascular anomalies resulting in liver hypoplasia and hepatic insufficiency. Cats with CPSS typically show signs of hepatic encephalopathy associated with increased ammonia, inflammatory cytokines, and oxidative stress. Surgical attenuation of the CPSS results in improved liver function, resolution of clinical signs, and increased portal blood flow. Hepatic gene expression has not previously been investigated in cats with CPSS. Here, we compared the hepatic expression of genes involved in the urea cycle ( CPS1 , NAGS ), angiogenesis ( VEGFR2 , NPPA , NPR1 , NPPC , NPR2 , HIF1a ), liver regeneration ( SERPINB1 , HGF , TGFβ ), and metabolism ( FGF21 ) from a small series of cats ( n = 18) with CPSS to that of control cats ( n = 10)...
February 26, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535794/the-role-of-snake-venom-disintegrins-in-angiogenesis
#7
REVIEW
Patricia Bianca Clissa, Maisa Splendore Della-Casa, Bianca Cestari Zychar, Sabri Saeed Sanabani
Angiogenesis, the formation of new blood vessels, plays a critical role in various physiological and pathological conditions. Snake venom disintegrins (SVDs) have been identified as significant regulators of this process. In this review, we explore the dual roles of SVD in angiogenesis, both as antiangiogenic agents by inhibiting integrin binding and interfering with vascular endothelial growth factors and as proangiogenic agents by enhancing integrin binding, stimulating cell migration and proliferation, and inducing neoangiogenesis...
March 1, 2024: Toxins
https://read.qxmd.com/read/38535295/exercise-alleviates-aging-of-adipose-tissue-through-adipokine-regulation
#8
REVIEW
Dandan Jia, Huijie Zhang, Tiemin Liu, Ru Wang
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis...
February 22, 2024: Metabolites
https://read.qxmd.com/read/38534878/the-effects-of-negative-pressure-therapy-on-hair-growth-of-mouse-models
#9
JOURNAL ARTICLE
Chun-Yu Cheng, Ming-Huei Cheng, Chin-Yu Yang, Cheng-Han Wang, Joshua Lim, Wei Huang, Chih-Hsin Lin
Negative pressure therapy (NPT) has been shown to facilitate wound healing and promote hair growth in a porcine model. However, there is a paucity of research on the impact of negative pressure on hair growth in murine models. Despite the ability of nude mice to develop hair follicles, the hair they produce is often flawed due to genetically induced keratin disorders, rendering them a pertinent animal model for assessing hair regeneration. Therefore, this study aims to investigate the effects of negative pressure on hair follicle growth in a nude mouse model...
March 27, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38534736/unraveling-the-multifaceted-role-of-the-mir-17-92-cluster-in-colorectal-cancer-from-mechanisms-to-biomarker-potential
#10
REVIEW
Hakeemah H Al-Nakhle
Colorectal cancer (CRC) is a complex disease driven by intricate mechanisms, making it challenging to understand and manage. The miR-17-92 cluster has gained significant attention in CRC research due to its diverse functions and crucial role in various aspects of the disease. This cluster, consisting of multiple individual miRNAs, influences critical processes like tumor initiation, angiogenesis, metastasis, and the epithelial-mesenchymal transition (EMT). Beyond its roles in tumorigenesis and progression, miR-17-92's dysregulation in CRC has substantial implications for diagnosis, prognosis, and treatment, including chemotherapy responsiveness...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534723/the-role-of-aminopeptidase-erap1-in-human-pathology-a-review
#11
REVIEW
Laura Țiburcă, Dana Carmen Zaha, Maria Claudia Jurca, Emilia Severin, Aurora Jurca, Alexandru Daniel Jurca
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic reticulum aminopeptidase 2), and LNPEP (coding for leucyl and cystinyl aminopeptidase). These genes encoding these enzymes are contiguous and located on the same chromosome (5q21); they share structural homology and functions and are associated with immune-mediated diseases...
February 20, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534606/hydrogels-in-cutaneous-wound-healing-insights-into-characterization-properties-formulation-and-therapeutic-potential
#12
REVIEW
Mariana Ribeiro, Marco Simões, Carla Vitorino, Filipa Mascarenhas-Melo
Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol...
March 8, 2024: Gels
https://read.qxmd.com/read/38534600/fibrin-based-hydrogels-with-reactive-amphiphilic-copolymers-for-mechanical-adjustments-allow-for-capillary-formation-in-2d-and-3d-environments
#13
JOURNAL ARTICLE
Svenja Wein, Carina Schemmer, Miriam Aischa Al Enezy-Ulbrich, Shannon Anna Jung, Stephan Rütten, Mark Kühnel, Danny Jonigk, Wilhelm Jahnen-Dechent, Andrij Pich, Sabine Neuss
This study focuses on enhancing controllable fibrin-based hydrogels for tissue engineering, addressing existing weaknesses. By integrating a novel copolymer, we improved the foundation for cell-based angiogenesis with adaptable structural features. Tissue engineering often faces challenges like waste disposal and nutrient supply beyond the 200 µm diffusion limit. Angiogenesis breaks through this limitation, allowing the construction of larger constructs. Our innovative scaffold combination significantly boosts angiogenesis, resulting in longer branches and more capillary network junctions...
March 6, 2024: Gels
https://read.qxmd.com/read/38534382/tofogliflozin-delays-portal-hypertension-and-hepatic-fibrosis-by-inhibiting-sinusoidal-capillarization-in-cirrhotic-rats
#14
JOURNAL ARTICLE
Shohei Asada, Kosuke Kaji, Norihisa Nishimura, Aritoshi Koizumi, Takuya Matsuda, Misako Tanaka, Nobuyuki Yorioka, Shinya Sato, Koh Kitagawa, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
BACKGROUND: Liver cirrhosis leads to portal hypertension (PH) with capillarization of liver sinusoidal endothelial cells (LSECs), although drug treatment options for PH are currently limited. Sodium glucose transporter 2 inhibitors, which are antidiabetic agents, have been shown to improve endothelial dysfunction. We aimed to elucidate the effect of tofogliflozin on PH and liver fibrosis in a rat cirrhosis model. METHODS: Male-F344/NSlc rats repeatedly received carbon tetrachloride (CCl4 ) intraperitoneally to induce PH and liver cirrhosis alongside tofogliflozin (10 or 20 mg/kg)...
March 19, 2024: Cells
https://read.qxmd.com/read/38534357/differentiation-of-adipose-tissue-mesenchymal-stem-cells-into-endothelial-cells-depends-on-fat-depot-conditions-regulation-by-mirna
#15
JOURNAL ARTICLE
Gemma Arderiu, Anna Civit-Urgell, Alberto Díez-Caballero, Fabrizio Moscatiello, Carlos Ballesta, Lina Badimon
The development of obesity is associated with substantial modulation of adipose tissue (AT) structure. The plasticity of the AT is reflected by its remarkable ability to expand or reduce in size throughout the adult lifespan, which is linked to the development of its vasculature. This increase in AT vasculature could be mediated by the differentiation of adipose tissue-derived stem cells (ASCs) into endothelial cells (ECs) and form new microvasculature. We have already shown that microRNA (miRNA)-145 regulates the differentiation of ASCs into EC-like (ECL) cells...
March 14, 2024: Cells
https://read.qxmd.com/read/38534334/hdac6-enhances-endoglin-expression-through-deacetylation-of-transcription-factor-sp1-potentiating-bmp9-induced-angiogenesis
#16
JOURNAL ARTICLE
Chen Sun, Kuifang Xie, Lejie Yang, Shengyang Cai, Mingjie Wang, Yizhun Zhu, Beibei Tao, Yichun Zhu
Histone deacetylase 6 (HDAC6) plays a crucial role in the acetylation of non-histone proteins and is notably implicated in angiogenesis, though its underlying mechanisms were previously not fully understood. This study conducted transcriptomic and proteomic analyses on vascular endothelial cells with HDAC6 knockdown, identifying endoglin (ENG) as a key downstream protein regulated by HDAC6. This protein is vital for maintaining vascular integrity and plays a complex role in angiogenesis, particularly in its interaction with bone morphogenetic protein 9 (BMP9)...
March 11, 2024: Cells
https://read.qxmd.com/read/38533625/aspirin-loaded-anti-inflammatory-zno-sio-2-aerogel-scaffolds-for-bone-regeneration
#17
JOURNAL ARTICLE
Yue Zhao, Caiqi Cheng, Xinyi Wang, Zhengchao Yuan, Binbin Sun, Mohamed El-Newehy, Meera Moydeen Abdulhameed, Bing Fang, Xiumei Mo
The increasing aging of the population has elevated bone defects to a significant threat to human life and health. Aerogel, a biomimetic material similar to an extracellular matrix (ECM), is considered an effective material for the treatment of bone defects. However, most aerogel scaffolds suffer from immune rejection and poor anti-inflammatory properties and are not well suited for human bone growth. In this study, we used electrospinning to prepare flexible ZnO-SiO2 nanofibers with different zinc concentrations and further assembled them into three-dimensional composite aerogel scaffolds...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38533506/engineered-therapeutic-antibodies-with-mannose-6-phosphate-analogues-as-a-tool-to-degrade-extracellular-proteins
#18
JOURNAL ARTICLE
Morgane Daurat, Corentin Gauthier, Khaled El Cheikh, Lamiaa M A Ali, Elodie Morère, Nadir Bettache, Magali Gary-Bobo, Alain Morère, Marcel Garcia, Marie Maynadier, Ilaria Basile
Inducing the degradation of pathological soluble antigens could be the key to greatly enhancing the efficacy of therapeutic monoclonal antibodies (mAbs), extensively used in the treatment of autoimmune and inflammatory disorders or cancer. Lysosomal targeting has gained increasing interest in recent years due to its pharmaceutical applications far beyond the treatment of lysosomal diseases, as a way to address proteins to the lysosome for eventual degradation. Mannose 6-phosphonate derivatives (M6Pn), called AMFA, are unique glycovectors that can significantly enhance the cellular internalization of the proteins conjugated to AMFA via the cation-independent mannose 6-phosphate receptor (M6PR) pathway...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533315/editorial-key-proteins-of-tumor-angiogenesis-potential-therapeutic-targets-for-gastrointestinal-tumors
#19
EDITORIAL
Weilong Zhong
No abstract text is available yet for this article.
2024: Frontiers in Medicine
https://read.qxmd.com/read/38533036/clinical-effects-and-mechanisms-of-a-chinese-patent-medicine-tongxinluo-capsule-as-an-adjuvant-treatment-in-coronary-heart-disease
#20
REVIEW
Jing Wang, Tian Li Li, Pei Fen Chang, Yu Qian Gao, Jia Sai Fan, Chen Hao Zhang, Hai Yan Zhu
Coronary heart disease (CHD) is the leading cause of death globally, posing a serious threat to human health. However, the current treatment approaches available for CHD fall short of the ideal results. Tongxinluo (TXL) is a traditional Chinese medicine (TCM) that has been employed in the clinical treatment of cardiovascular and cerebrovascular diseases (such as angina pectoris, stroke, etc.) in China for many years and holds great potential as a prospective treatment. TXL either as a standalone treatment or in combination with interventions recommended in CHD guidelines has been shown to be effective and well tolerated in clinical trials for CHD...
March 30, 2024: Heliyon
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