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https://www.readbyqxmd.com/read/29245053/influence-of-diabetes-on-the-foreign-body-response-to-nitric-oxide-releasing-implants
#1
Robert J Soto, Elizabeth P Merricks, Dwight A Bellinger, Timothy C Nichols, Mark H Schoenfisch
The foreign body response (FBR) to nitric oxide (NO)-releasing subcutaneous implants was compared between healthy and streptozotocin-induced diabetic swine by evaluating inflammation, collagen capsule formation, and angiogenesis. Steel wire substrates were first modified with polyurethane membranes capable of diverse NO-release kinetics (NO fluxes and release durations of 0.8-630.0 pmol cm-2 s-1 and 2-13 d, respectively). The NO-releasing materials were implanted in the subcutis for 3, 10, or 25 d for histological and immunohistochemical evaluation of the FBR...
November 30, 2017: Biomaterials
https://www.readbyqxmd.com/read/29244726/potential-of-bioactive-glasses-for-cardiac-and-pulmonary-tissue-engineering
#2
REVIEW
Saeid Kargozar, Sepideh Hamzehlou, Francesco Baino
Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such as myocardial infarction. The inherent properties of BGs, including their ability to bond to hard and soft tissues, to stimulate angiogenesis, and to elicit antimicrobial effects, along with their excellent biocompatibility, support these newly proposed strategies...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29244692/reconstruction-of-extended-bone-defects-using-massive-allografts-combined-with-surgical-angiogenesis-a-case-report
#3
Victoria Struckmann, Gerhard Schmidmaier, Thomas Ferbert, Ulrich Kneser, Thomas Kremer
CASE: A 20-year-old patient presented with an extended composite knee defect with destruction of the medial femoral condyle, including the medial collateral ligament. Treatment included using an anterolateral thigh flap for soft-tissue reconstruction, tensor fasciae latae muscle for ligament repair, and a massive allogenic bone graft of the medial femoral condyle that was revascularized with an osteocutaneous composite free flap from the contralateral femur. At 17 months postoperatively, the outcome was evaluated with scores on several established scales and radiographic assessment...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29243968/chlorogenic-acid-enriched-extract-of-ilex-kudingcha-c-j-tseng-inhibits-angiogenesis-in-zebrafish
#4
Tao Zhong, Linghua Piao, Hyun Jung Kim, Xiande Liu, Shengnan Jiang, Guomin Liu
Kudingcha is a particularly bitter tasting tea that has been widely used in China to eliminate fever and itching eyes, and to clear blood toxins. Kudingcha is considered of value for its potential anticancer effects that are attributed to the presence of characteristic bioactive ingredients. The chlorogenic acid (CGA) derivatives 3-0-caffeoylquinic acid, 5-0-caffeoylquinic acid, 3,5-0-dicaffeoylquinic acid, and 4,5-0-dicaffeoylquinic acid were separated from Ilex kudingcha C.J. Tseng extract by high-performance liquid chromatography (HPLC)-photodiode array detector (PDA) and HPLC-nuclear magnetic resonance (NMR)...
December 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29243842/exosomes-secreted-by-hypoxic-cardiosphere-derived-cells-enhance-tube-formation-and-increase-pro-angiogenic-mirna
#5
Helia Namazi, Elham Mohit, Iman Namazi, Sarah Rajabi, Azam Samadian, Ensiyeh Hajizadeh-Saffar, Nasser Aghdami, Hossein Baharvand
Exosomes are required for the regenerative effects of human cardiosphere-derived cells (CDCs). Studies show that they mimic the cardioprotective benefits of CDCs in rodents and porcine myocardial infarction (MI) models. Hypoxic preconditioning of stem cells increases the cardioprotective effects of exosomes in MI models by enhancing angiogenesis. Several exosomal microRNAs (miRNAs) up-regulate in response to hypoxia and play a role in cardioprotective and pro-angiogenic effects. In this study, we have demonstrated that human CDCs secreted exosomes under hypoxic conditions (1% O2 for 2 days) enhanced tube formation by human umbilical vein endothelial cells (HUVECs) at a concentration of 25 μg/ml...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243194/kallistatin-inhibits-lymphangiogenesis-and-lymphatic-metastasis-of-gastric-cancer-by-downregulating-vegf-c-expression-and-secretion
#6
Caiqi Ma, Chuanghua Luo, Haofan Yin, Yang Zhang, Wenjun Xiong, Ting Zhang, Tianxiao Gao, Xi Wang, Di Che, Zhenzhen Fang, Lei Li, Jinye Xie, Mao Huang, Liuqing Zhu, Ping Jiang, Weiwei Qi, Ti Zhou, Zhonghan Yang, Wei Wang, Jianxing Ma, Guoquan Gao, Xia Yang
BACKGROUND: Tumor-induced lymphangiogenesis and lymphatic metastasis are predominant during the metastasis of many types of cancers. However, the endogenous inhibitors that counterbalance the lymphangiogenesis and lymphatic metastasis of tumors have not been well evaluated. Kallistatin has been recognized as an endogenous angiogenesis inhibitor. METHODS AND RESULTS: Our recent study showed for the first time that the lymphatic vessel density (LVD) was reduced in lung and stomach sections from kallistatin-overexpressing transgenic mice...
December 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29243184/study-of-myb-nfib-chimeric-gene-expression-tumor-angiogenesis-and-proliferation-in-adenoid-cystic-carcinoma-of-salivary-gland
#7
Junya Ono, Yasuo Okada
Adenoid cystic carcinoma (ACC) is one of the common malignant tumors in salivary glands, and the clinical prognosis is poor with frequent distant metastasis which may lead to death. Expression of the MYB-NFIB chimeric gene in ACC has been reported recently. MYB is an oncogene with transcription regulating functions, and NFIB encodes nuclear transcription factor although detailed functions are unknown. This study investigated whether MYB-NFIB chimeric gene expression affects tumor angiogenesis and proliferation in salivary gland ACC...
December 14, 2017: Odontology
https://www.readbyqxmd.com/read/29243036/mediators-of-angiogenesis-and-fibrosis-in-igg4-related-disease
#8
Ilaria Puxeddu, Riccardo Capecchi, Federico Pratesi, Silvana Cianchetti, Antonio Tavoni, Paola Migliorini
IgG4-related disease (IgG4-RD) is a rare fibro-inflammatory condition that can affect almost any organ, characterized by tumefactive lesions and often by eosinophilia and elevated serum IgG4 concentrations. The aim of the study is to analyze in IgG4-RD patients the serum levels of a group of cytokines and growth factors potentially involved in the regulation of fibrotic processes. In the sera of 12 patients affected by IgG4-RD and of 15 normal healthy subjects (NHS), pro-fibrogenic mediators (TGF-β1 and periostin) and pro- (VEGF and angiogenin-1) and anti- (endostatin and thrombospondin-1) angiogenic mediators were measured by sandwich enzyme immunoassay...
December 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29242645/retinal-angiogenesis-regulates-astrocytic-differentiation-in-neonatal-mouse-retinas-by-oxygen-dependent-mechanisms
#9
Li-Juan Duan, Sarah J Pan, Thomas N Sato, Guo-Hua Fong
In mice, retinal vascular and astrocyte networks begin to develop at birth, expanding radially from the optic nerve head (ONH) towards the retinal periphery. The retinal vasculature grows towards the periphery ahead of differentiated astrocytes, but behind astrocytic progenitor cells (APCs) and immature astrocytes. Endothelial cell specific Vegfr-2 disruption in newborn mice not only blocked retinal vascular development but also suppressed astrocytic differentiation, reducing the abundance of differentiated astrocytes while causing the accumulation of precursors...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242604/ribosomal-protein-s15a-promotes-tumor-angiogenesis-via-enhancing-wnt-%C3%AE-catenin-induced-fgf18-expression-in-hepatocellular-carcinoma
#10
Pengyi Guo, Yi Wang, Chunxiu Dai, Chonglin Tao, Fang Wu, Xiaozai Xie, Haitao Yu, Qiandong Zhu, Junjian Li, Longyun Ye, Fuxiang Yu, Yunfeng Shan, Zhengping Yu, Renumathy Dhanasekaran, Rongyuan Zheng, Gang Chen
Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear. In this study, an evaluation of RPS15A expression in 110 surgically resected HCCs and matched tumor-adjacent normal tissues revealed an overexpression of RPS15A in HCC, which was correlated with worse survival...
December 15, 2017: Oncogene
https://www.readbyqxmd.com/read/29242271/snf1-sucrose-nonfermenting-1-related-kinase-promotes-angiogenesis-in-vivo
#11
Qiulun Lu, Zhonglin Xie, Chenghui Yan, Ye Ding, Zejun Ma, Shengnan Wu, Yu Qiu, Stephanie M Cossette, Michelle Bordas, Ramani Ramchandran, Ming-Hui Zou
OBJECTIVE: Snf1 (sucrose nonfermenting 1)-related kinase (SNRK) is a novel member of the AMPK (AMP-activated protein kinase)-related superfamily that is activated in the process of angiogenesis. Currently, little is known about the function of SNRK in angiogenesis in the physiological and pathological condition. APPROACH AND RESULTS: In this study, in Snrk global heterozygous knockout mice, retina angiogenesis and neovessel formation after hindlimb ischemia were suppressed...
December 14, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29242157/determination-of-green-s-function-for-three-dimensional-traction-force-reconstruction-based-on-geometry-and-boundary-conditions-of-cell-culture-matrices
#12
Y Du, S C B Herath, Q G Wang, H Asada, P C Y Chen
Cell migration plays a particular important role in the initiation and progression of many physical processes and pathological conditions such as tumor invasion and metastasis. Three-dimensional traction force microscopy (TFM) of high resolution and high accuracy is being developed in an effort to unveil the underlying mechanical process of cell migration in a vivo-like environment. Linear elasticity-based TFM (LETM) as a mainstream approach relies on the Green's function (that relates traction forces to matrix deformation), of which the inherent boundary conditions and geometry of the matrix could remarkably affect the result as suggested by previous 2D studies...
December 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29242144/recent-advances-in-understanding-the-roles-of-blood-platelets-in-the-pathogenesis-of-allergic-inflammation-and-bronchial-asthma
#13
REVIEW
Tomohiro Takeda, Hideaki Morita, Hirohisa Saito, Kenji Matsumoto, Akio Matsuda
Platelets play an essential role in hemostasis to minimize blood loss due to traumatic injury. In addition, they contain various immune-associated molecules and contribute to immunological barrier formation at sites of vascular injury, thereby protecting against invading pathogens. Platelets are also crucially involved in development of allergic diseases, including bronchial asthma. Platelets in asthmatics are more activated than those in healthy individuals. By using a murine asthma model, platelets were shown to be actively involved in progression of the disease, including in airway eosinophilia and airway remodeling...
December 11, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29242072/therapeutic-angiogenesis-by-local-sustained-release-of-microrna-126-using-poly-lactic-co-glycolic-acid-nanoparticles-in-murine-hindlimb-ischemia
#14
Shinichi Tsumaru, Hidetoshi Masumoto, Kenji Minakata, Masayasu Izuhara, Kazuhiro Yamazaki, Tadashi Ikeda, Koh Ono, Ryuzo Sakata, Kenji Minatoya
OBJECTIVE: Recent studies demonstrate that microRNAs show promising potential, including angiogenesis, in therapeutic intervention. MicroRNA-126 (miR-126) is reported to regulate angiogenesis by blocking Sprouty-related EVH1 domain-containing protein 1 (SPRED1), an endogenous inhibitor of vascular endothelial cell growth factor. In this study, we investigated the angiogenic effects of the sustained release of miR-126 loaded with poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) in a murine hindlimb ischemia model...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29242064/hypoxia-inducible-factor-1-in-clinical-and-experimental-aortic-aneurysm-disease
#15
Wei Wang, Baohui Xu, Haojun Xuan, Yingbin Ge, Yan Wang, Lixin Wang, Jianhua Huang, Weiguo Fu, Sara A Michie, Ronald L Dalman
OBJECTIVE: Mural angiogenesis and macrophage accumulation are two pathologic hallmarks of abdominal aortic aneurysm (AAA) disease. The heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) is an essential regulator of angiogenesis and macrophage function. In this study, we investigated HIF-1 expression and activity in clinical and experimental AAA disease. METHODS: Human aortic samples were obtained from 24 AAA patients and six organ donors during open abdominal surgery...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29242062/rationale-and-design-of-the-sail-trial-for-intramuscular-injection-of-allogeneic-mesenchymal-stromal-cells-in-no-option-critical-limb-ischemia
#16
Joep G J Wijnand, Martin Teraa, Hendrik Gremmels, Femke C C van Rhijn-Brouwer, Gert J de Borst, Marianne C Verhaar
BACKGROUND: Critical limb ischemia (CLI) represents the most severe form of peripheral artery disease and has an immense impact on quality of life, morbidity, and mortality. A considerable proportion of CLI patients are ineligible for revascularization, leaving amputation as the only option. Mesenchymal stromal cells (MSCs), because of their vasculoregenerative and immunomodulatory characteristics, have emerged as a potential new treatment. METHODS: The primary objective of this trial is to investigate whether intramuscular administration of allogeneic bone marrow (BM)-derived MSCs is safe and potentially effective...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29241546/neutrophils-and-snail-orchestrate-the-establishment-of-a-pro-tumor-microenvironment-in-lung-cancer
#17
Julien Faget, Svenja Groeneveld, Gael Boivin, Martial Sankar, Nadine Zangger, Miguel Garcia, Nicolas Guex, Inti Zlobec, Loïc Steiner, Alessandra Piersigilli, Ioannis Xenarios, Etienne Meylan
Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1+ neutrophils to disease progression. Depletion experiments showed that Gr1+ cells (1) favor tumor growth, (2) reduce T cell homing and prevent successful anti-PD1 immunotherapy, and (3) alter angiogenesis, leading to hypoxia and sustained Snail expression in lung cancer cells. In turn, Snail accelerated disease progression and increased intratumoral Cxcl2 secretion and neutrophil infiltration...
December 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/29241418/isolation-and-characterization-of-mesenchymal-stromal-cells-based-on-aldehyde-dehydrogenase-activity
#18
Mehdi Najar, Laurent Dollé, Emerence Crompot, Stefaan Verhulst, Leo Van Grunsven, Hélène Busser, Laurence Lagneaux
Mesenchymal stromal cells (MSCs) have particular properties that allow their use as therapeutic strategies for several cell-based applications. Historically, bone marrow (BM)-MSCs are isolated by culture adherence since specific cell surface markers are yet to be developed. This original work aimed to identify and characterize isolating expanded BM-MSCs based on their aldehyde dehydrogenase (ALDH) activity known to be a hallmark of stem cells and relevant for their isolation. We thus isolated by FACS technology two functionally different populations of BM-MSCs depending on their ALDH activity (ALDH+ and ALDH-)...
December 14, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29241208/exosomes-from-mir-126-overexpressing-adscs-are-therapeutic-in-relieving-acute-myocardial-ischaemic-injury
#19
Qiancheng Luo, Dongfeng Guo, Guorong Liu, Guo Chen, Min Hang, Mingming Jin
BACKGROUND/AIMS: Recent studies have indicated that exosomes play an important role in adipose-derived stem cell (ADSC) transplant-mediated ischaemic heart disease therapy. However, the treatment effect is not obvious. The aim of this study is to investigate whether ADSC-derived exosomes enriched with microRNA (miR)-126 have a more protective effect on acute myocardial infarction (AMI). METHODS: Exosomes were characterized by transmission electron microscopy, and the exosome particles were further examined using nanoparticle tracking analyses...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29240802/systemic-factors-related-to-soluble-pro-renin-receptor-in-plasma-of-patients-with-proliferative-diabetic-retinopathy
#20
Keitaro Hase, Atsuhiro Kanda, Ikuyo Hirose, Kousuke Noda, Susumu Ishida
(Pro)renin receptor [(P)RR], a new component of the tissue renin-angiotensin system (RAS), plays a crucial role in inflammation and angiogenesis in the eye, thus contributing to the development of proliferative diabetic retinopathy (PDR). In this study, we investigated systemic factors related to plasma levels of soluble form of (P)RR [s(P)RR] in patients with PDR. Twenty type II diabetic patients with PDR and 20 age-matched, non-diabetic patients with idiopathic macular diseases were enrolled, and plasma levels of various molecules were measured by enzyme-linked immunosorbent assays...
2017: PloS One
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