Andrea Marino, Giuliana Pavone, Federica Martorana, Viviana Fisicaro, Lucia Motta, Serena Spampinato, Benedetto Maurizio Celesia, Bruno Cacopardo, Paolo Vigneri, Giuseppe Nunnari
Despite significant advances in the management of antiretroviral therapy (ART), leading to improved life expectancy for people living with HIV (PLWH), the incidence of non-AIDS-defining cancers, including breast cancer, has emerged as a critical concern. This review synthesizes current evidence on the epidemiology of breast cancer among HIV-infected individuals, highlighting the potential for an altered risk profile, earlier onset, and more advanced disease at diagnosis. It delves into the molecular considerations underpinning the relationship between HIV and breast cancer, including the role of immunosuppression, chronic inflammation, and gene expression alterations...
March 12, 2024: International Journal of Molecular Sciences