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https://www.readbyqxmd.com/read/29330635/hypotension-due-to-spinal-anesthesia-influences-fetal-circulation-in-primary-caesarean-sections
#1
K Lato, I Bekes, Peter Widschwendter, T W P Friedl, W Janni, F Reister, G Froeba, U Friebe-Hoffmann
PURPOSE: Hypotension due to spinal anesthesia is a well-known side effect in pregnant women receiving caesarean section. Little is known about its impact on fetal blood circulation. METHODS: 40 women with uncomplicated singleton term pregnancies prepared for caesarean section were prospectively evaluated by Doppler sonography before and immediately after spinal anesthesia. RESULTS: In 90% of the women, blood pressure significantly decreased after spinal anesthesia and 42...
January 12, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29326857/role-of-color-doppler-flowmetry-in-prediction-of-intrauterine-growth-retardation-in-high-risk-pregnancy
#2
Sachin Khanduri, Saakshi Chhabra, Santosh Yadav, Tushar Sabharwal, Mriganki Chaudhary, Tarim Usmani, Aakshit Goyal, Hritik Sharma
OBJECTIVE: To evaluate the usefulness of Color Doppler flowmetry in the prediction of intrauterine growth restriction (IUGR) in high-risk pregnancies. MATERIALS AND METHOD: A total of 62 high-risk pregnant women underwent Color Doppler flowmetric umbilical artery pulsatility index (PI), resistive index (RI) and systolic/diastolic (S/D) ratio, middle cerebral artery PI, RI and S/D ratio, Ductus venosus S-wave/isovolumetric A-wave index (SIA) and vertebral artery RI at 23-27 weeks, 28-32 weeks and 32-36 weeks of their pregnancy...
November 8, 2017: Curēus
https://www.readbyqxmd.com/read/29313878/postpartum-ct-angiography-of-the-fetoplacental-macrovasculature-in-normal-pregnancies-and-in-those-complicated-by-fetal-growth-restriction
#3
Mette Østergaard Thunbo, Marianne Sinding, Anne Sofie Korsager, Jens Brøndum Frøkjaer, Lasse Riis Østergaard, Astrid Petersen, Charlotte Overgaard, Anne Sørensen
INTRODUCTION: Current knowledge of the fetoplacental vasculature in fetal growth restriction (FGR) due to placental dysfunction focuses on the microvasculature rather than the macrovasculature. The aim of this study was to investigate the feasibility of computed topography angiography to analyze the fetoplacental macrovasculature in normal and FGR pregnancies. MATERIAL AND METHODS: We included 29 placentas (22-42 weeks' gestation) from normal birthweight pregnancies and 8 placentas (26-37 weeks' gestation) from FGR pregnancies (birthweight < -15% and abnormal umbilical Doppler flow)...
January 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29309034/inverted-formin-2-regulates-intracellular-trafficking-placentation-and-pregnancy-outcome
#4
Katherine Young Bezold Lamm, Maddison L Johnson, Julie Baker Phillips, Michael B Muntifering, Jeanne M James, Helen N Jones, Raymond W Redline, Antonis Rokas, Louis J Muglia
Healthy pregnancy depends on proper placentation-including proliferation, differentiation, and invasion of trophoblast cells-which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia. Mechanisms regulating trophoblast invasion, however, are unknown. We report that reduction of Inverted formin 2 (INF2) alters intracellular trafficking and significantly impairs invasion in a model of human extravillous trophoblasts. Furthermore, global loss of Inf2 in mice recapitulates maternal and fetal phenotypes of placental insufficiency...
January 8, 2018: ELife
https://www.readbyqxmd.com/read/29298964/-assessment-of-relationship-between-doppler-flows-in-pregnancies-after-41-week-and-the-incidence-of-cesarean-sections-with-induced-labour
#5
Hanna Makles, Jacek R Wilczyński
HASH(0x4cb9dd8) AIM: The aim of the study was to assess a relationship between the Doppler flows in foetal vessels, i.e. the middle cerebral artery (MCA), umbilical artery (UMA), umbilical vein (UV) and ductus venosus (DV) as well as in maternal vessels, i.e. the right uterine artery (UAR), left uterine artery (UAL) and the incidence of cesarean sections in pregnancies after 41 week with induced labour. MATERIALS AND METHODS: The study included 130 pregnant women, including 100 pregnant women, between 41 and 42 weeks of gestation, in whom induced labour resulted in a cesarean section due to three main indications: lack of progress of labour (Group I-44), signs of foetal distress (Group II-32) and lack of response to induced labour (Group III-24)...
December 22, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29298455/preterm-preeclampsia-with-severe-features-composite-maternal-and-neonatal-morbidities-associated-with-fetal-growth-restriction
#6
Olaide Ashimi Balogun, Raminder K Khanagura, Heather R Kregel, Farah H Amro, Baha M Sibai, Suneet P Chauhan
OBJECTIVE:  The objective of this study was to compare adverse pregnancy outcomes between fetuses with estimated fetal weight (EFW) < 10 to > 10% in women with preterm preeclampsia (PE) with severe features. MATERIALS AND METHODS:  All women with preterm PE with severe features and nonanomalous singletons with EFW were identified at a tertiary center. Women with oligohydramnios or absent/reversed umbilical Doppler velocimetry were excluded. Using multivariable analysis, we compared the composite maternal and neonatal morbidities (CMM and CNM) between those with appropriate for gestational age (AGA) fetal growth, defined as EFW at 10 to 90th versus those with fetal growth restriction (FGR), defined as EFW < 10th percentile for gestational age (GA)...
January 3, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29287136/cerebrovascular-hemodynamics-in-fetuses-with-congenital-heart-disease
#7
Tingting Man, Yihua He, Ying Zhao, Lin Sun, Xiaowei Liu, Shuping Ge
BACKGROUND AND OBJECTIVE: It is hypothesized that diminished cerebral vascular resistance or the "brain sparing effect" is associated with fetuses with complex congenital heart defects (CHD) and may affect their neurodevelopmental outcome. An alternative explanation is that it is related to the location, cardiac output, pressure, and resistance in left heart obstructive CHDs. We sought to determine the effects of various left and right heart obstructive defects on the cerebral and placental hemodynamics and to evaluate the utility of these variables for the assessment and prognosis of CHDs...
December 2017: Echocardiography
https://www.readbyqxmd.com/read/29286910/selective-iugr-in-dichorionic-twins-what-can-doppler-assessment-and-growth-discordancy-say-about-neonatal-outcomes
#8
Paola Algeri, Matteo Frigerio, Maria Lamanna, Petya Vitanova Petrova, Sabrina Cozzolino, Maddalena Incerti, Salvatore Andrea Mastrolia, Nadia Roncaglia, Patrizia Vergani
OBJECTIVE: The aim of the present study was to assess, in a population of dichorionic twin pregnancies with selective growth restriction, the effect of inter-twin differences by use of Doppler velocimetry and fetal growth discordancy on perinatal outcomes. METHODS: This was a retrospective study including dichorionic twin pregnancies from January 2008 to December 2015 at the Department of Obstetrics and Gynecology of Fondazione MBBM. Only dichorionic twin pregnancies affected by selective intrauterine growth restriction (IUGR) delivering at ≥24 weeks were included in the study...
December 29, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29281153/microvascular-perfusion-of-the-placenta-developing-fetal-liver-and-lungs-assessed-with-intravoxel-incoherent-motion-imaging
#9
András Jakab, Ruth L Tuura, Raimund Kottke, Nicole Ochsenbein-Kölble, Giancarlo Natalucci, Thi Dao Nguyen, Christian Kellenberger, Ianina Scheer
BACKGROUND: In utero intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) provides a novel method for examining microvascular perfusion fraction and diffusion in the developing human fetus. PURPOSE: To characterize gestational changes in the microvascular perfusion fraction of the placenta, fetal liver, and lungs using IVIM-MRI. STUDY TYPE: Retrospective, cross-sectional study. SUBJECTS: Fifty-five datasets from 33 singleton pregnancies were acquired (17-36 gestational weeks)...
December 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29235099/variations-from-morning-to-afternoon-of-middle-cerebral-and-umbilical-artery-blood-flow-and-fetal-heart-rate-variability-and-fetal-characteristics-in-the-normally-developing-fetus
#10
Tehila Avitan, Ari Sanders, Ursula Brain, Dan Rurak, Tim F Oberlander, Ken Lim
OBJECTIVE: To determine if there are changes in maternal uterine blood flow, fetal brain blood flow, fetal heart rate variability, and umbilical blood flow between morning (AM) and afternoon (PM) in healthy, uncomplicated pregnancies. STUDY DESIGN: In this prospective study, 68 uncomplicated singleton pregnancies (mean 35 + 0.7 weeks gestation) underwent a standard observational protocol at both 08:00 (AM) and 13:30 (PM) of the same day. This protocol included Doppler measurements of uterine, umbilical, and fetal middle cerebral artery (MCA) volume flow parameters (flow, HR, peak systolic velocity [PSV], PI, and RI) followed by computerized cardiotocography...
December 13, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29227585/effect-of-ultrafiltration-on-placental-fetal-blood-flow-in-pregnancy-of-woman-undergoing-chronic-hemodialysis
#11
Luiz Paulo José Marques, Paulo Roberto Silva Marinho, Regina Rocco, Caroline de Azevedo Martins, Henrique Novo Costa Pereira, Ana Clara Lopes Barbosa Ferreira
INTRODUCTION: Patient who was undergoing hemodialysis (HD) thrice weekly usually gain 1 to 4 kg of weight in interdialytic period, mainly due to fluid accumulation by ingestion of water. Ultrafiltration (UF) during HD will be need to remove fluid excess to avoid severe medical complications secondary to fluid overload. However, in pregnant woman UF can increase the episodes of intradialytic hypotension which may lead to placental ischemic injury and predispose to fetal distress. There is little information about safe fluid amount withdrawn by UF during pregnancy...
December 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29212571/expression-of-homeobox-gene-hlx-and-its-downstream-target-genes-are-altered-in-placentae-from-discordant-twin-pregnancies
#12
Nicola Yuen, Shaun P Brennecke, Mark P Umstad, Hannah E J Yong, Anthony J Borg, Gayathri Rajaraman, Bill Kalionis, Padma Murthi
A discordant twin gestation, in which one fetus is significantly growth restricted, compared to the other normal twin, is a unique model that can be used to elucidate the mechanism(s) by which the intrauterine environment affects fetal growth. In many model systems, placental transcription factor genes regulate fetal growth. Transcription factors regulate growth through their activation or repression of downstream target genes that mediate important cell functions. The objective of this study was to determine the expression of the placental HLX homeobox gene transcription factor and its downstream target genes in dizygotic twins with growth discordance...
December 7, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29197294/gestational-ultrasonography-and-dopplerfluxometry-in-capuchin-monkeys-sapajus-apella-zoometric
#13
S A Miranda, D L Leão, K G Oliveira, I S Sodré, S F S Domingues
The objectives of the current study were as follows: 1) to evaluate blood flow in the uterine (UA) and umbilical (Uma) arteries in pregnant capuchin monkeys by measuring the resistive index (RI) and pulsatility index (PI); 2) to determine the presence or absence of the early diastolic notch and diastolic flow in the UA and Uma flow waveforms, respectively; 3) to perform conceptus echobiometry for fetal growth assessment during pregnancy; 4) to describe the moment that the fetal organs were initially observed; and 5) to determine when the diagnosis of fetal gender is possible...
November 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/29192281/high-speed-high-frequency-ultrasound-in-utero-vector-flow-imaging-of-mouse-embryos
#14
Jeffrey A Ketterling, Orlando Aristizábal, Billy Y S Yiu, Daniel H Turnbull, Colin K L Phoon, Alfred C H Yu, Ronald H Silverman
Real-time imaging of the embryonic murine cardiovascular system is challenging due to the small size of the mouse embryo and rapid heart rate. High-frequency, linear-array ultrasound systems designed for small-animal imaging provide high-frame-rate and Doppler modes but are limited in regards to the field of view that can be imaged at fine-temporal and -spatial resolution. Here, a plane-wave imaging method was used to obtain high-speed image data from in utero mouse embryos and multi-angle, vector-flow algorithms were applied to the data to provide information on blood flow patterns in major organs...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29183631/birth-weight-to-placenta-weight-ratio-and-its-relationship-to-ultrasonic-measurements-maternal-and-neonatal-morbidity-a-prospective-cohort-study-of-nulliparous-women
#15
N Salavati, S J Gordijn, U Sovio, R Zill-E-Huma, A Gebril, D S Charnock-Jones, S A Scherjon, G C S Smith
INTRODUCTION: Birth weight to placenta weight (BWPW)-ratio is an indicator of the ability of the placenta to maintain adequate nutrient supply to the fetus. We sought to investigate the relationship between BWPW-ratio with fetal growth, utero-placental Doppler and neonatal and maternal morbidity. METHODS: We studied a group of 3311 women recruited to a prospective cohort study of nulliparous women (Rosie Hospital, Cambridge, UK) who delivered a live born infant at term and whose placental weight and birth weight were known...
November 15, 2017: Placenta
https://www.readbyqxmd.com/read/29172821/risk-of-donor-demise-after-laser-therapy-for-twin-twin-transfusion-when-complicated-by-growth-discordance-and-abnormal-umbilical-artery-doppler-findings
#16
Matthew M Finneran, Megan A Templin, Courtney D Stephenson
OBJECTIVE: To investigate the natural course of abnormal umbilical artery Doppler (UAD) findings in donor fetuses after laser surgery and the prognostic significance of resolution, persistence, or new onset UAD abnormalities with and without the presence of preoperative growth discordance. STUDY DESIGN: Retrospective cohort study of all monochorionic-diamniotic multi-fetal gestations diagnosed with twin-twin transfusion syndrome (TTTS) undergoing laser surgery at a single large metropolitan referral center from 2010-2016...
November 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29121743/profiling-of-cardiovascular-and-cerebrovascular-disease-associated-microrna-expression-in-umbilical-cord-blood-in-gestational-hypertension-preeclampsia-and-fetal-growth-restriction
#17
Ilona Hromadnikova, Katerina Kotlabova, Katarina Ivankova, Yulia Vedmetskaya, Ladislav Krofta
BACKGROUND AND METHODS: Gene expression of 29 cardiovascular and cerebrovascular disease associated microRNAs was assessed in whole umbilical cord blood, compared between groups [47 gestational hypertension (GH), 56 preeclampsia (PE), 37 fetal growth restriction (FGR) and 44 normal pregnancies] and correlated with the severity of the disease with respect to clinical signs (mild PE vs. severe PE), delivery date (before and after 34weeks of gestation), and Doppler ultrasound parameters [pulsatility index (PI) in the umbilical artery, PI in the middle cerebral artery and the cerebroplacental ratio]...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29112084/feed-related-splanchnic-oxygenation-in-preterm-infants-with-abnormal-antenatal-doppler-developing-gut-complications
#18
Silvia Martini, Arianna Aceti, Isadora Beghetti, Giacomo Faldella, Luigi Corvaglia
Preterm infants with antenatal absent or reversed end diastolic flow (AREDF) in umbilical arteries are at major risk for gastrointestinal (GI) complications, such as necrotizing enterocolitis, intestinal perforation and feeding intolerance. Near-infrared spectroscopy (NIRS) provides continuous monitoring of splanchnic oxygenation (SrSO2) and might represent a useful tool to predict GI outcomes in this high-risk population.This observational, pilot study assessed feed-related SrSO2 patterns at enteral feeding introduction and full enteral feeding (FEF) achievement in twenty AREDF infants with gestational age ≤34 weeks...
November 3, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29110317/fetal-growth-standards-in-gastroschisis-reference-values-for-ultrasound-measurements
#19
Mariane Massaini Barbieri, João Renato Bennini, Marcelo Luís Nomura, Sirlei Siani Morais, Fernanda Garanhani Surita
OBJECTIVES: To create growth curves based on ultrasonography biometric parameters of fetuses with gastroschisis, comparing them with normal growth standards and to analyze umbilical artery (AU) Doppler velocimetry patterns. METHODS: A cohort study of 72 fetuses with gastroschisis, at gestational ages between 14 and 39 weeks was designed. Mean and standard deviation were calculated, with the 5th, 10th, 50th, 90th and 95th centiles being established for biometric parameters according to gestational age...
November 7, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29105215/re-outcome-of-monochorionic-twin-pregnancy-with-selective-intrauterine-growth-restriction-according-to-umbilical-artery-doppler-flow-pattern-of-smaller-twin-systematic-review-and-meta-analysis-d-buca-g-pagani-g-rizzo-a-familiari-m-e-flacco-l-manzoli-m-liberati
#20
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