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https://read.qxmd.com/read/38561731/familial-dilated-cardiomyopathy-in-a-child-a-case-report
#1
JOURNAL ARTICLE
Ali Ismail, Dima Khreis, Amani Assaad, Marianne Nimah Majdalani
BACKGROUND: Dilated cardiomyopathy (DCM) commonly leads to heart failure (HF) and represents the most common indication for cardiac transplantation in the pediatric population. Clinical manifestations of DCM are mainly the symptoms of heart failure; it is diagnosed by EKG, chest x-ray and echocardiography. For the idiopathic and familial diseases cases of DCM, there are no definite guidelines for treatment in children as they are treated for prognostic improvement. CASE PRESENTATION: We report the case of a 2-year-old girl diagnosed with dilated cardiomyopathy associated with homozygous mutation in the Myosin Light Chain 3 gene admitted for edema in lower extremities, muscle weakness, lethargy and vomiting, and she was found to be in cardiogenic shock...
April 1, 2024: BMC Pediatrics
https://read.qxmd.com/read/38186521/idiopathic-fascicular-ventricular-tachycardia-in-a-pediatric-patient-with-suicidal-ideation-and-self-injurious-behavior
#2
Margaret A Uchefuna, Ruth Y Eletta, Arleen Delgado, Susan Beker
Idiopathic fascicular ventricular tachycardia (IFVT) is an arrhythmia that occurs in a structurally normal heart and may present with sudden onset in a healthy individual. We present the case of a 10-year-old female child, with no pertinent medical history, who complained of palpitations and shortness of breath, which was followed by suicidal ideations. On presentation to the ER, tachycardia was noted with other vital signs within normal limits. Labs were unremarkable. EKG showed wide-complex tachycardia with right bundle branch block and left superior axis, consistent with idiopathic left ventricular fascicular tachycardia...
December 2023: Curēus
https://read.qxmd.com/read/38025026/from-private-practice-to-academia-the-experience-of-a-general-academic-pediatrician
#3
JOURNAL ARTICLE
Philip Kum-Nji
After pediatric residency, the author worked in a rural community where he was able to immediately practice skills acquired during training such as intubations, bag-mask ventilation, IV placement, ear irrigation, foreign body removal from eyes and ears, abscess incision and drainage, intraosseous placement for rapid hydration of a severely dehydrated infant, EKG, X-ray readings, and ear-irrigations to cite but a few examples. Furthermore, the writer acquired other high-valued procedural skills such as neonatal male circumcision, frenotomy, ligation of supernumerary digits, and manual separation of labial adhesions...
2023: Journal of Medical Education and Curricular Development
https://read.qxmd.com/read/37927770/crochetage-the-forgotten-electrocardiographic-sign
#4
Carol Fernandez Hazim, Mohammed Shaban, Dessiree Cordero, Ana P Urena Neme, Miguel A Rodriguez Guerra
Acquired complete heart block is a rare but severe arrhythmia caused by various factors such as infections, medications, and autoimmune conditions. Atrial septal defect (ASD) is a common congenital heart defect, with larger ASDs possibly causing symptoms such as fatigue, shortness of breath, and frequent respiratory infections. In some cases, high-grade atrioventricular block with ASD can occur; however, the exact incidence is not well established. We report a rare case of a 15-year-old male presenting with acute dizziness...
October 2023: Curēus
https://read.qxmd.com/read/37822779/ekg-acquisition-curriculum-for-pediatric-trainees
#5
JOURNAL ARTICLE
Vladislav Obsekov, Christopher Teng, Dorene F Balmer
OBJECTIVES: Pediatric residency trainees interface with electrocardiograms (EKG) as part of routine clinical care. Depending on workflow and availability of support staff, trainees may be required to obtain EKGs on patients, though training on this skill varies. Our intervention seeks to train incoming pediatric residents on obtaining EKGs from pediatric patients and identifying common problems that may result in acquisition of low-fidelity EKGs. METHODS: A team of physicians, EKG technicians, and simulation educators designed a 30-min didactic and experiential learning opportunity for incoming pediatric trainees held prior to their start of clinical responsibilities...
2023: Journal of Medical Education and Curricular Development
https://read.qxmd.com/read/37682427/chronic-doxepin-toxicity-masquerading-as-epilepsy-in-a-10-year-old-boy
#6
JOURNAL ARTICLE
James D Whitledge, C James Watson, Michele M Burns
INTRODUCTION: Chronic tricyclic antidepressant toxicity is rarely described in children. Symptoms include confusion, ataxia, and seizures. Toxicity may result from dosing error, CYP2C19 and CYP2D6 genetic variability, and drug-drug interactions. Chronic doxepin toxicity has not been previously reported in children. Doxepin is prescribed for insomnia and depression, with a maximum off-label dose of 3 mg/kg in children. We present a case of chronic doxepin toxicity mimicking epilepsy in a child attributable to three potential factors: supratherapeutic dosing, pharmacogenomic variability, and drug-drug interactions...
September 8, 2023: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://read.qxmd.com/read/37624409/qrs-duration-after-pulmonary-valve-replacement-in-adults-with-repaired-tetralogy-of-fallot-association-with-ventricular-arrhythmia-and-correlation-with-right-ventricular-size
#7
JOURNAL ARTICLE
Rody G Bou Chaaya, Emily Barron, Jeremy L Herrmann, John W Brown, Georges Ephrem
The aim of this study is to analyze the relationship between QRS duration after pulmonary valve replacement (PVR) and ventricular arrhythmias (VA) in patients with repaired tetralogy of Fallot (ToF). ToF patients may face complications such as heart failure and VA after primary repair, often mitigated by PVR. Prior studies have shown a decrease in QRS duration and right ventricular (RV) size following PVR. It remains unclear whether a lack of QRS duration reduction identifies patients at risk of VA. We retrospectively identified adult patients with repaired ToF who underwent surgical or transcatheter PVR...
August 25, 2023: Pediatric Cardiology
https://read.qxmd.com/read/37436141/characteristics-of-vitamin-d-deficiency-hypocalcemia-inpatient-admissions-at-a-single-tertiary-center
#8
JOURNAL ARTICLE
Victoria H Bustamante, Andrea Estrada, Nadia Merchant
Objective: Severe 25-hydroxyvitamin D (25(OH)D) deficiency can result in life-threatening presentations due to hypocalcemia leading to seizures and cardiac arrhythmias. Vitamin D deficiency is a common cause of hypocalcemia and rickets in children; however, there are no recent studies on the burden of inpatient admissions in the United States. Our study aims to describe the clinical characteristics and risk factors of inpatient admissions due to severe hypocalcemia and 25(OH)D deficiency at a freestanding academic children's hospital...
July 13, 2023: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/37423027/significance-of-electrocardiogram-abnormalities-in-children-presenting-to-the-emergency-department-with-acute-covid-19-infection
#9
JOURNAL ARTICLE
Andrew Van Hersh, Kahir Jawad, Yana Feygin, Christopher Johnsrude, Soham Dasgupta
OBJECTIVES: Acute COVID-19 infection may be associated with electrocardiogram (EKG) abnormalities in pediatric patients. We have anecdotally observed EKG abnormalities in patients without MIS-C or significant cardiac disease requiring intervention or further follow-up. Our aim was to determine the incidence of abnormal EKG findings and correlate with evidence of significant cardiac pathology in pediatric patients who present to the emergency department during an acute COVID-19 infection...
June 28, 2023: American Journal of Emergency Medicine
https://read.qxmd.com/read/37302919/bnt162b2-immunization-related-myocarditis-in-adolescents-and-consequent-hospitalization-report-from-a-medical-center
#10
JOURNAL ARTICLE
Chen-Wei Yen, Jung Lee, Ya-Ting Chang, En-Pei Lee, Chang-Teng Wu, Yi-Jung Chang
BACKGROUND: To investigate Pfizer-BioNTech 162b2 mRNA COVID-19 vaccine (BNT162b2) immunization-related myocarditis and describe the risk factors for consequent hospitalization in the pediatric intensive care unit (PICU) in children between 12 and 18 years. METHODS: Children and adolescents 12 years of age and older who presented with discomfort after BNT162b2 immunization (BNTI) and visited pediatric emergency room (PER) at Chang Gung Memorial Hospital from September 22, 2021 to March 21, 2022, were included for analysis...
May 24, 2023: Pediatrics and Neonatology
https://read.qxmd.com/read/37265890/autoimmune-polyendocrinopathy-in-a-pediatric-patient-presenting-with-multisystem-inflammatory-syndrome-in-children-mis-c
#11
Chaitanya Sambangi, Patrice Collins, Julisa Patel, Jacqueline Chan
Multisystem inflammatory syndrome (MIS) is a well-known potential sequela of COVID-19 infection. Though prevalence is higher in certain populations, this syndrome is a rare occurrence in children. Beyond MIS, there has been increasing research into COVID infection and the subsequent onset of autoimmune conditions, such as diabetes. However, evidence of a poly-endocrinopathy developing after COVID infection is lacking, and evidence within the pediatric population is virtually nonexistent. In this case, we present the evolution of an autoimmune polyglandular syndrome (APS) type 2 phenotype, consisting of type 1 diabetes, Graves' disease, and adrenal insufficiency, after diagnosis of multisystem inflammatory syndrome of children (MIS-C) in a pediatric patient...
May 2023: Curēus
https://read.qxmd.com/read/36909288/a-case-series-evaluation-of-comprehensive-drug-testing-in-the-pediatric-acute-care-setting
#12
JOURNAL ARTICLE
Kara L Lynch
INTRODUCTION: Drug testing typically follows a one-size-fits-all approach that is inadequate in some clinical scenarios, such as child maltreatment, neglect, and unintentional drug exposure. Results from immunoassay-based testing, which are non-specific, insensitive, and far from comprehensive, can lead to unintended consequences for children and their families. OBJECTIVES: The objective of this retrospective case series study is to evaluate the utility of real-time (0-1 day) comprehensive drug testing as an alternative to immunoassay-based testing in the pediatric acute care setting...
April 2023: Journal of mass spectrometry and advances in the clinical lab
https://read.qxmd.com/read/36845322/enzyme-replacement-therapy-ert-on-heart-function-changes-the-outcome-in-patients-with-infantile-onset-pompe-disease-a-familial-history
#13
Marco Lecis, Katia Rossi, Maria Elena Guerzoni, Ilaria Mariotti, Lorenzo Iughetti
BACKGROUND: Lysosomal acid alpha-glucosidase (GAA) deficiency, also known as Pompe disease, is an autosomal recessive disorder that leads to the accumulation of glycogen in lysosomes and cytoplasm, resulting in tissue destruction. Infantile-onset GAA deficiency is characterized by cardiomyopathy and severe generalized hypotonia. Without treatment, most patients die within the first two years of life. The demonstration of reduced GAA activity, followed by sequencing of the GAA gene, confirms the disease...
2023: Case Reports in Pediatrics
https://read.qxmd.com/read/36608381/perioperative-outcomes-in-children-with-hashimoto-s-thyroiditis-undergoing-total-thyroidectomy
#14
JOURNAL ARTICLE
Inbal Hazkani, Evan Edwards, Eli Stein, John Maddalozzo, Douglas R Johnston, Jill Samis, Jami Josefson, Jeffrey Rastatter
BACKGROUND: Hashimoto's thyroiditis (HT) affects 1-2 % of the pediatric population. In adults with HT, thyroidectomy is considered challenging and prone to postoperative complications due to the chronic inflammatory process. However, the complications of thyroidectomy among children with HT have not been established. The objective of our study was to evaluate whether children with HT undergoing total thyroidectomy for presumed thyroid cancer have higher complication rates than children without HT...
December 31, 2022: American Journal of Otolaryngology
https://read.qxmd.com/read/36583236/a-worldwide-survey-on-the-variability-in-checking-the-tip-position-of-pediatric-central-venous-catheter
#15
JOURNAL ARTICLE
Anna Camporesi, Veronica Diotto, Federica Pederiva
No abstract text is available yet for this article.
December 29, 2022: Paediatric Anaesthesia
https://read.qxmd.com/read/36337791/classic-presentation-of-catecholaminergic-polymorphic-ventricular-tachycardia-a-case-report
#16
Emily E Hill, Amanda Schoonover, Christopher Benner, Todd P Chassee
Syncope is a common reason for children and adolescents to seek care in the emergency department. Often syncopal episodes are benign and most commonly due to a vasovagal event. Occasionally an underlying cardiac arrhythmia is responsible. We present a case report of a 17-year-old male who collapsed during an emotional event and went into cardiac arrest. Emergency department evaluation including imaging, laboratory studies, and EKG indicated the cause of cardiac arrest was likely a primary cardiac arrhythmia...
October 2022: Curēus
https://read.qxmd.com/read/35928043/cytokine-profile-in-children-with-severe-multisystem-inflammatory-syndrome-related-to-the-coronavirus-disease-2019
#17
JOURNAL ARTICLE
Miguel Rodríguez-Rubio, Juan J Menéndez-Suso, Carmen Cámara-Hijón, Miguel Río-García, María Laplaza-González, Irene Amores-Hernández, María P Romero-Gómez, Elena Álvarez-Rojas, Diana Salas-Mera, Eduardo López-Granados, Pedro de la Oliva
The multisystem inflammatory syndrome in children (MIS-C) is a novel and concerning entity related to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Although MIS-C has been the subject of intensive research efforts, its pathophysiology and optimal treatment remain elusive. We studied the clinical features, laboratory findings, and immunoinflammatory profiles of seven children prospectively admitted to a pediatric intensive care unit (PICU) during the first wave of the pandemic. All patients had immunoglobulin (Ig)-G against SARS-CoV-2, four of seven patients had both IgM and IgG, and in one of the 7 SARS-CoV-2 was detected in a respiratory sample...
September 2022: Journal of Pediatric Intensive Care
https://read.qxmd.com/read/35873396/clinical-outcomes-of-pfizer-biontech-covid-19-vaccine-in-children-and-adolescents-a-systematic-review
#18
JOURNAL ARTICLE
Ahmad R Al-Qudimat, Raed M Al-Zoubi, Mai Elaarag, Abdulqadir J Nashwan, Afaf K Hamze, Hiba Bawadi, Aksam Yassin, Aseel Assim, Omar M Aboumarzouk, Ahmad Zarour, Abdulla A Al-Ansari
BACKGROUND & AIMS: The BioNTech-Pfizer vaccine is the only vaccine offered to children among all available vaccines. However, limited evidence is available about the clinical outcomes of COVID-19 vaccines, especially among children and adolescents. This review offers a comprehensive and up-to-date overview of the BioNTech-Pfizer vaccine's current information on children and adolescents. METHODS: The review was conducted following the PRISMA guidelines; a comprehensive search was performed in PubMed, Scopus, MEDLINE, and EMBASE databases for research publications COVID-19 published between December 2019 and October 2021...
July 2022: Health Science Reports
https://read.qxmd.com/read/35663665/covid-19-vaccine-cardiac-complications-a-case-series-on-implications-of-marijuana-in-adolescents-with-myopericarditis
#19
Sahil Zaveri, Helen Kest, Bhavin Shah, William DeBruin, Mario Colletti
We report on two critically ill pediatric patients, aged 16 and 18 years, presenting with acute myopericarditis at a tertiary-care center in New Jersey, United States. Both patients had their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations, tested negative for SARS-CoV-2, and shared only significant history of asthma. Clinical presentations were similar to acute onset chest pain that worsened with deep inspiration. One patient reported a history of vaping and escalating marijuana use several hours preceding presentation...
May 2022: Curēus
https://read.qxmd.com/read/35660129/wearable-technology-leads-to-initial-workup-of-graves-disease-in-an-adolescent-female
#20
JOURNAL ARTICLE
Seth C Shanefield, Maria N Kelly, Molly Posa
Graves' disease is the most common form of hyperthyroidism in the pediatric population. While the most prevalent symptoms seen in children with Graves' disease include goiter and excessive sweating (Minamitani et al., 2017), diagnosis is frequently delayed due to presentation with non-specific symptoms (Léger et al., 2018). This case report is of a 12-year-old female who presented to her pediatrician with a one month history of episodes of tachycardia both with physical exertion and at rest. Notably, these episodes were discovered on her electronic smartwatch by its heart rate monitoring feature...
September 2022: Journal of Adolescent Health
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