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Meconium aspiration and mechanicals ventilation

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https://www.readbyqxmd.com/read/27711045/non-invasive-inhaled-nitric-oxide-in-the-treatment-of-hypoxemic-respiratory-failure-in-term-and-preterm-infants
#1
R Sahni, X Ameer, K Ohira-Kist, J-T Wung
OBJECTIVES: Inhaled nitric oxide (iNO) is effective in conjunction with tracheal intubation (TI) and mechanical ventilation (MV) for treating arterial pulmonary hypertension and hypoxemic respiratory failure (HRF) in near-term and term newborns. Non-invasive respiratory support with nasal continuous positive airway pressure (CPAP) is increasingly used to avoid morbidity associated with TI and MV, yet the effectiveness of iNO delivery via nasal CPAP remains unknown. To evaluate the effectiveness of iNO delivered via the bubble nasal CPAP system in term and preterm newborns with HRF...
October 6, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27220313/lung-ultrasound-as-a-predictor-of-mechanical-ventilation-in-neonates-older-than-32-weeks
#2
Javier Rodríguez-Fanjul, Carla Balcells, Victoria Aldecoa-Bilbao, Julio Moreno, Martín Iriondo
BACKGROUND: The prognosis of neonatal respiratory distress may be difficult to estimate at admission. Lung ultrasound is a useful diagnostic tool that is quick, requires little training, and is radiation free. OBJECTIVE: This study aims to analyze whether early lung ultrasound can predict respiratory failure. METHODS: From January to December 2014, lung ultrasound was performed on neonates admitted with breathing difficulties if they were older than 32 weeks and not intubated...
2016: Neonatology
https://www.readbyqxmd.com/read/27206687/current-concepts-in-the-management-of-meconium-aspiration-syndrome
#3
REVIEW
Subhash Chettri, B Vishnu Bhat, B Adhisivam
In developing countries, meconium aspiration syndrome (MAS) is an important cause of morbidity and mortality among neonates. The concepts of pathophysiology and management of meconium stained amniotic fluid (MSAF) and meconium aspiration syndrome have undergone tremendous change in recent years. Routine intranatal and postnatal endotracheal suctioning of meconium in vigorous infants is no longer recommended. Recent studies have challenged its role even in non-vigorous infants. Supportive therapy like oxygen supplementation, mechanical ventilation and intravenous fluids are the cornerstone in the management of meconium aspiration syndrome...
October 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27109092/surfactant-therapy-and-antibiotics-in-neonates-with-meconium-aspiration-syndrome-a-systematic-review-and-meta-analysis
#4
C K Natarajan, M J Sankar, K Jain, R Agarwal, V K Paul
Meconium aspiration syndrome (MAS), a common cause of respiratory failure in neonates, is associated with high mortality and morbidity. The objectives of this review were to evaluate the effects of administration of (a) surfactant-either as lung lavage (SLL) or bolus surfactant (BS) and (b) antibiotics on mortality and severe morbidities in neonates with MAS. We searched the following databases: MEDLINE via PubMed, Cochrane CENTRAL, WHOLIS and CABI using sensitive search strategies. We included eight studies on use of surfactant and three studies on use of antibiotics...
May 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27010895/effects-of-surfactant-budesonide-therapy-on-oxidative-modifications-in-the-lung-in-experimental-meconium-induced-lung-injury
#5
P Mikolka, J Kopincova, L Tomcikova Mikusiakova, P Kosutova, M Antosova, A Calkovska, D Mokra
Meconium aspiration syndrome (MAS) is a serious condition, which can be treated with exogenous surfactant and mechanical ventilation. However, meconium-induced inflammation, lung edema and oxidative damage may inactivate delivered surfactant and thereby reduce effectiveness of the therapy. As we presumed that addition of anti-inflammatory agent into the surfactant may alleviate inflammation and enhance efficiency of the therapy, this study was performed to evaluate effects of surfactant therapy enriched with budesonide versus surfactant-only therapy on markers of oxidative stress in experimental model of MAS...
February 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/26987323/high-frequency-jet-ventilation-against-small-volume-conventional-mechanical-ventilation-in-the-rabbit-models-of-neonatal-acute-lung-injury
#6
D Mokra, L Tomcikova Mikusiakova, P Mikolka, P Kosutova, M Jurcek, M Kolomaznik, A Calkovska
Patients with acute lung injury are ventilated by conventional mechanical ventilation (CMV) rather than high-frequency jet ventilation (HFJV). This study estimated the potential usefulness of HFJV in acute lung injury. The issue was addressed by comparing the effects on lung function of CMV and HFJV in two rabbit models of neonatal acute lung injury: repetitive saline lung lavage (LAV) and meconium aspiration syndrome (MAS) induced by intratracheal meconium instillation. The animals were then ventilated with either HFJV or CMV for 4 h...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26959212/umbilical-cord-venous-lactate-for-predicting-arterial-lactic-acidemia-and-neonatal-morbidity-at-term
#7
Methodius G Tuuli, Molly J Stout, George A Macones, Alison G Cahill
OBJECTIVE: To estimate the utility of umbilical venous lactate, more readily available than umbilical cord arterial lactate, for predicting arterial lactic acidemia and neonatal outcomes at term. METHODS: This was a prospective cohort study of consecutive, nonanomalous, singleton, term births after labor in a large academic medical center (2009-2014). Umbilical arterial and venous lactate were measured immediately after delivery, before knowledge of neonatal outcomes...
April 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26866711/continuous-end-tidal-carbon-dioxide-monitoring-during-resuscitation-of-asphyxiated-term-lambs
#8
Praveen Kumar Chandrasekharan, Munmun Rawat, Jayasree Nair, Sylvia F Gugino, Carmon Koenigsknecht, Daniel D Swartz, Payam Vali, Bobby Mathew, Satyan Lakshminrusimha
BACKGROUND: The Neonatal Resuscitation Program (NRP) recommends close monitoring of oxygenation during the resuscitation of newborns using a pulse oximeter. However, there are no guidelines for monitoring carbon dioxide (CO2) to assess ventilation. Considering that cerebral blood flow (CBF) correlates directly with PaCO2, continuous capnography monitoring of end-tidal CO2 (ETCO2) may limit fluctuations in PaCO2 and, therefore, CBF during resuscitation of asphyxiated infants. OBJECTIVE: To evaluate whether continuous monitoring of ETCO2 with capnography during resuscitation of asphyxiated term lambs with meconium aspiration will prevent fluctuations in PaCO2 and carotid arterial blood flow (CABF)...
2016: Neonatology
https://www.readbyqxmd.com/read/26663621/inflammatory-indices-in-meconium-aspiration-syndrome
#9
Nora Hofer, Katharina Jank, Volker Strenger, Jasmin Pansy, Bernhard Resch
INTRODUCTION: Meconium aspiration syndrome (MAS) is linked to inflammation, but data on the patterns of hematological indices and C-reactive protein (CRP) in MAS are lacking. The aim of the study was to evaluate CRP, white blood cell count (WBC), absolute neutrophil count (ANC), and immature-to-total neutrophil ratio (IT-ratio) in MAS and to assess their association with disease severity. METHODS: Retrospective cross-sectional study including 239 consecutively admitted neonates with MAS to a level III NICU...
June 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/26633188/treatment-of-neonates-with-meconium-aspiration-syndrome-by-proportional-assist-ventilation-and-synchronized-intermittent-mandatory-ventilation-a-comparison-study
#10
Rong Wu, Zhao-Fang Tian, Guo-Fang Zheng, Su-Fang Din, Zi-Bo Gao, Zhi-Chun Feng
BACKGROUND: This study aimed to compare the relevant clinical parameters of neonates with MAS who are supported by proportion assisted ventilation (PAV) and synchronized intermittent mandatory ventilation (SIMV). METHODS: Forty neonates diagnosed as MAS who required mechanical ventilation were divided randomly into PAV group and SIMV group (N.=20). The respiratory rate (RR), heart rate (HR), peak inspiratory pressure (PIP), mean arterial blood pressure (MABP), arterial-to-alveolar oxygen tension ratio (a/APO2), fraction of inspiration oxygen (FiO2), mean airway pressure (MAP) and tidal volume (VT) were measured before the ventilation, 1,12, 24, 48 hours after the ventilation and before weaning...
August 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/26599471/planned-early-delivery-versus-expectant-management-of-the-term-suspected-compromised-baby-for-improving-outcomes
#11
REVIEW
Diana M Bond, Adrienne Gordon, Jon Hyett, Bradley de Vries, Angela E Carberry, Jonathan Morris
BACKGROUND: Fetal compromise in the term pregnancy is suspected when the following clinical indicators are present: intrauterine growth restriction (IUGR), decreased fetal movement (DFM), or when investigations such as cardiotocography (CTG) and ultrasound reveal results inconsistent with standard measurements. Pathological results would necessitate the need for immediate delivery, but the management for 'suspicious' results remains unclear and varies widely across clinical centres. There is clinical uncertainty as to how to best manage women presenting with a suspected term compromised baby in an otherwise healthy pregnancy...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26421487/histologic-evidence-of-intrapulmonary-bronchopulmonary-anastomotic-pathways-in-neonates-with-meconium-aspiration-syndrome
#12
Noorjahan Ali, Steven H Abman, Csaba Galambos
We examined lung histology from 8 infants who died with meconium aspiration syndrome in order to determine the presence of intrapulmonary bronchopulmonary anastomotic pathways. Each infant required mechanical ventilation to treat hypoxemic respiratory distress. Lung histology from each infant shows evidence of prominent bronchopulmonary vascular connections.
December 2015: Journal of Pediatrics
https://www.readbyqxmd.com/read/26017729/effects-on-lung-function-of-small-volume-conventional-ventilation-and-high-frequency-oscillatory-ventilation-in-a-model-of-meconium-aspiration-syndrome
#13
L Tomcikova Mikusiakova, H Pistekova, P Kosutova, P Mikolka, A Calkovska, D Mokra
For treatment of severe neonatal meconium aspiration syndrome (MAS), lung-protective mechanical ventilation is essential. This study compared short-term effects of small-volume conventional mechanical ventilation and high-frequency oscillatory ventilation on lung function in experimentally-induced MAS. In conventionally-ventilated rabbits, MAS was induced by intratracheal instillation of meconium suspension (4 ml/kg, 25 mg/ml). Then, animals were ventilated conventionally with small-volume (f-50/min; VT-6 ml/kg) or with high frequency ventilation (f-10/s) for 4 h, with the evaluation of blood gases, ventilatory pressures, and pulmonary shunts...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/25738789/tidal-volume-requirement-in-mechanically-ventilated-infants-with-meconium-aspiration-syndrome
#14
Saumya Sharma, Shane Clark, Kabir Abubakar, Martin Keszler
OBJECTIVE: The aim of the study is to test the hypothesis that increased physiologic dead space and functional residual capacity seen in meconium aspiration syndrome (MAS) results in higher tidal volume (VT) requirement to achieve adequate ventilation. STUDY DESIGN: Retrospective review of infants with MAS admitted to our hospital from 2000 to 2010 managed with conventional ventilation. Demographics, ventilator settings, VT, respiratory rate (RR), and blood gas values were recorded...
August 2015: American Journal of Perinatology
https://www.readbyqxmd.com/read/25669694/n-acetylcysteine-advancement-of-surfactant-therapy-in-experimental-meconium-aspiration-syndrome-possible-mechanisms
#15
J Kopincová, D Mokrá, P Mikolka, M Kolomazník, A Čalkovská
Meconium aspiration syndrome (MAS) is meconium-induced respiratory failure of newborns associated with activation of inflammatory and oxidative pathways. For severe MAS, exogenous surfactant treatment is used which improves respiratory functions but does not treat the inflammation. Oxidative process can lead to later surfactant inactivation; hence, surfactant combination with antioxidative agent may enhance the therapeutic effect. Young New Zealand rabbits were instilled by meconium suspension and treated by surfactant alone, N-acetylcysteine (NAC) alone or by their combination and oxygen-ventilated for 5 h...
2014: Physiological Research
https://www.readbyqxmd.com/read/25374369/antibiotics-for-meconium-stained-amniotic-fluid-in-labour-for-preventing-maternal-and-neonatal-infections
#16
REVIEW
Thitiporn Siriwachirachai, Ussanee S Sangkomkamhang, Pisake Lumbiganon, Malinee Laopaiboon
BACKGROUND: Chorioamnionitis is more likely to occur when meconium-stained amniotic fluid (MSAF) is present. Meconium may enhance the growth of bacteria in amniotic fluid by serving as a growth factor, inhibiting bacteriostatic properties of amniotic fluid. Many adverse neonatal outcomes related to MSAF result from meconium aspiration syndrome (MAS). MSAF is associated with both maternal and newborn infections. Antibiotics may be an effective option to reduce such morbidity. OBJECTIVES: The objective of this review is to assess the efficacy and side effects of prophylactic antibiotics for MSAF during labour in preventing maternal and neonatal infections...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25256123/blood-lactate-level-and-meconium-aspiration-syndrome
#17
Nalan Karabayir, Ali Demirel, Elvan Bayramoglu
PURPOSE: Approximately 5% of infants born with a meconium-stained amniotic fluid (MSAF) develop meconium aspiration syndrome (MAS). Early recognition of infants at highest risk for the development of MAS and the prediction of disease severity are important for optimizing the clinical strategies for prevention and treatment. The aim of the present study was to identify the risk factors for MAS and to investigate the effect of blood lactate level on the development of MAS. METHODS: Between January 2011 and January 2012, data were recorded with regard to gender, mode of delivery, gestational week, birth weight, 5-min Apgar score, and need for resuscitation of the meconium-stained depressed infants who underwent tracheal aspiration...
April 2015: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/25198278/umbilical-cord-arterial-lactate-compared-with-ph-for-predicting-neonatal-morbidity-at-term
#18
COMPARATIVE STUDY
Methodius G Tuuli, Molly J Stout, Anthony Shanks, Anthony O Odibo, George A Macones, Alison G Cahill
OBJECTIVE: To test the hypothesis that umbilical cord arterial lactate is superior to pH for predicting short-term neonatal morbidity at term. METHODS: We conducted a prospective cohort study of all consecutive, non-anomalous, singleton, vertex, term births from 2009 to 2012 at Washington University Medical Center. Umbilical arterial lactate and pH were measured immediately after delivery, before knowledge of neonatal outcomes. The primary outcome was a composite neonatal morbidity consisting of neonatal death, intubation, mechanical ventilation, meconium aspiration syndrome, hypoxic encephalopathy, and need for hypothermic therapy...
October 2014: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25149271/impact-of-oxygen-concentration-on-time-to-resolution-of-spontaneous-pneumothorax-in-term-infants-a-population-based-cohort-study
#19
COMPARATIVE STUDY
Huma Shaireen, Yacov Rabi, Amy Metcalfe, Majeeda Kamaluddeen, Harish Amin, Albert Akierman, Abhay Lodha
BACKGROUND: Little evidence exists regarding the optimal concentration of oxygen to use in the treatment of term neonates with spontaneous pneumothorax (SP). The practice of using high oxygen concentrations to promote "nitrogen washout" still exists at many centers. The aim of this study was to identify the time to clinical resolution of SP in term neonates treated with high oxygen concentrations (HO: FiO2 ≥ 60%), moderate oxygen concentrations (MO: FiO2 < 60%) or room air (RA: FiO2 = 21%)...
2014: BMC Pediatrics
https://www.readbyqxmd.com/read/25008878/-clinical-effect-of-endotracheal-lavage-with-porcine-pulmonary-surfactant-in-term-neonates-with-severe-meconium-aspiration-syndrome
#20
RANDOMIZED CONTROLLED TRIAL
Xin-Zhu Lin, Ji-Dong Lai, Zhao-Yang Lan, Ya-Yin Lin
OBJECTIVE: To evaluate the clinical effect of endotracheal lavage with porcine pulmonary surfactant (PS) in term neonates with severe meconium aspiration syndrome (MAS). METHODS: A total of 136 full-term infants with severe MAS who were admitted to the neonatal intensive care unit between January 2010 and June 2013 were randomly and equally divided into PS lavage and PS injection groups. In the PS lavage group, patients were treated with endotracheal lavage using 3-5 mL of diluted PS (12 mg/mL) each time, and the PS injection group was given PS by intratracheal injection at the first dose of 200 mg/kg...
July 2014: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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