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N-acetylcysteine and psychiatric disorders

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https://www.readbyqxmd.com/read/29106990/white-light-emitting-diode-suppresses-proliferation-and-induces-apoptosis-in-hippocampal-neuron-cells-through-mitochondrial-cytochrome-c-oxydase-mediated-igf-1-and-tnf-%C3%AE-pathways
#1
Yang Yang, Yibo Zong, Qinwei Sun, Yimin Jia, Ruqian Zhao
Light emitting diode (LED) light has been tested to treat traumatic brain injury, neural degenerative diseases and psychiatric disorders. Previous studies indicate that blue LED light affects cell proliferation and apoptosis in photosensitive cells and cancer cells. In this study, we demonstrate that white LED light exposure impaired proliferation and induced apoptosis in HeLa and HT-22 hippocampal neural cells, but not C2C12 cells. Furthermore, the mechanisms underlying the effect of white LED light exposure on HT-22 cells were elucidated...
October 26, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29053023/n-acetylcysteine-for-nonsuicidal-self-injurious-behavior-in-adolescents-an-open-label-pilot-study
#2
Kathryn R Cullen, Bonnie Klimes-Dougan, Melinda Westlund Schreiner, Patricia Carstedt, Nicholas Marka, Katharine Nelson, Michael J Miller, Kristina Reigstad, Ana Westervelt, Meredith Gunlicks-Stoessel, Lynn E Eberly
BACKGROUND: Nonsuicidal self-injury (NSSI) is common in adolescents and young adults, and few evidence-based treatments are available for this significant problem. N-acetylcysteine (NAC) is a widely available nutritional supplement that has been studied in some psychiatric disorders relevant to NSSI including mood and addictive disorders. This pilot study tested the use of NAC as a potential treatment for NSSI in youth. METHODS: Thirty-five female adolescents and young adults with NSSI aged 13-21 years were enrolled in this study that had an open-label, single-arm study design...
October 20, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28954106/trichotillomania-a-good-response-to-treatment-with-n-acetylcysteine
#3
Livia Ariane Lopes Barroso, Flavia Sternberg, Maria Natalia Inacio de Fraia E Souza, Gisele Jacobino de Barros Nunes
Trichotillomania is considered a behavioral disorder and is characterized by the recurring habit of pulling one's hair, resulting in secondary alopecia. It affects 1% of the adult population, and 2 to 4.4% of psychiatric patients meet the diagnostic criteria. It can occur at any age and is more prevalent in adolescents and females. Its occurrence in childhood is not uncommon and tends to have a more favorable clinical course. The scalp, eyebrows and eyelashes are the most commonly affected sites. Glutamate modulating agents, such as N-acetylcysteine, have been shown to be a promising treatment...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28922069/glutamatergic-agents-in-the-treatment-of-compulsivity-and-impulsivity-in-child-and-adolescent-psychiatry-a-systematic-review-of-the-literature
#4
Konstantin Mechler, Alexander Häge, Nina Schweinfurth, Jeffrey C Glennon, Rick M Dijkhuizen, Declan Murphy, Sarah Durston, Steven Williams, Jan K Buitelaar, Tobias Banaschewski, Ralf W Dittmann, The Tactics Consortium
OBJECTIVE: Research has implicated glutamatergic projections between the various frontal subregions in the pathogenesis of compulsivity and impulsivity. Reducing striatal glutamate release, or antagonising the action of glutamate at its receptors, may therefore represent viable treatment strategies. Several glutamatergic agents with regulatory approval for other indications are available and may be of potential benefit in the treatment of compulsivity/impulsivity in psychiatric disorders in paediatric patients...
September 18, 2017: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/28797292/the-ethanol-extract-of-aquilariae-lignum-ameliorates-hippocampal-oxidative-stress-in-a-repeated-restraint-stress-mouse-model
#5
Hyun-Yong Lee, Jin-Seok Lee, Hyeong-Geug Kim, Won-Yong Kim, Seung-Bae Lee, Yung-Hyun Choi, Chang-Gue Son
BACKGROUND: Chronic stress contributes to the development of brain disorders, such as neurodegenerative and psychiatric diseases. Oxidative damage is well known as a causative factor for pathogenic process in brain tissues. The aim of this study is to evaluate the neuroprotective effect of a 30% ethanol extract of Aquilariae Lignum (ALE) in repeated stress-induced hippocampal oxidative injury. METHODS: Fifty BALB/c male mice (12 weeks old) were randomly divided into five groups (n = 10)...
August 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28152236/gender-differences-among-treatment-seeking-adults-with-cannabis-use-disorder-clinical-profiles-of-women-and-men-enrolled-in-the-achieving-cannabis-cessation-evaluating-n-acetylcysteine-treatment-accent-study
#6
Brian J Sherman, Aimee L McRae-Clark, Nathaniel L Baker, Susan C Sonne, Therese K Killeen, Kasie Cloud, Kevin M Gray
BACKGROUND AND OBJECTIVES: Recent evidence suggests that women may fare worse than men in cannabis trials with pharmacologic interventions. Identifying baseline clinical profiles of treatment-seeking cannabis-dependent adults could inform gender-specific treatment planning and development. METHODS: The current study compared baseline demographic, cannabis use, and psychiatric factors between women (n = 86) and men (n = 216) entering the Achieving Cannabis Cessation-Evaluating N-acetylcysteine Treatment (ACCENT) study, a multi-site, randomized controlled trial conducted within the National Drug Abuse Treatment Clinical Trials Network...
March 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28047652/su-f-sps-07-magnetic-resonance-spectroscopy-findings-in-early-phase-psychosis
#7
A Wright, R Ma, T Hummer, M Francis, N Mehdiyoun, U Dydak, A Breier
PURPOSE: Schizophrenia is a psychiatric disorder characterized by disordered thoughts, abnormal social behaviors, flat affect, and auditory or visual hallucinations. The current study aims to investigate alterations in brain metabolism in patients near the onset of psychosis (early-phase psychosis, EPP), to characterize abnormalities during the early stages of schizophrenia. To this end, we used magnetic resonance imaging (MRI) and spectroscopy (MRS) to measure metabolite levels and subsequently monitor the effect of treatment with N-acetylcysteine (NAC)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27766914/n-acetylcysteine-in-the-treatment-of-psychiatric-disorders-current-status-and-future-prospects
#8
REVIEW
Alessandro Minarini, Silvia Ferrari, Martina Galletti, Nina Giambalvo, Daniela Perrone, Giulia Rioli, Gian Maria Galeazzi
N-acetylcysteine (NAC) is widely known for its role as a mucolytic and as an antidote to paracetamol overdose. There is increasing interest in the use of NAC in the treatment of several psychiatric disorders. The rationale for the administration of NAC in psychiatric conditions is based on its role as a precursor to the antioxidant glutathione, and its action as a modulating agent of glutamatergic, dopaminergic, neurotropic and inflammatory pathways. Areas covered: This study reviews the available data regarding the use of NAC in different psychiatric disorders including substance use disorders, autism, obsessive-compulsive spectrum disorders, schizophrenia, depression, bipolar disorder...
March 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27725170/anxiolytic-properties-of-n-acetylcysteine-in-mice
#9
Patrícia Santos, Ana P Herrmann, Radharani Benvenutti, Guilherme Noetzold, Franciele Giongo, Clarissa S Gama, Angelo L Piato, Elaine Elisabetsky
Anxiety disorders are highly prevalent and often result in poor quality of life. Available anxiolytics show significant adverse effects as well as partial efficacy in a sizable part of patients. Innovative treatments with more favorable risk-benefit ratio are sorely needed. A growing body of clinical data indicates the benefits of N-acetylcysteine (NAC) in psychiatric conditions. NAC modulates antioxidant, glutamatergic, inflammatory and neurotrophic pathways in the central nervous system, all of which are relevant to anxiety pathology...
October 7, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27179791/n-acetylcysteine-modulates-glutamatergic-dysfunction-and-depressive-behavior-in-huntington-s-disease
#10
Dean J Wright, Laura J Gray, David I Finkelstein, Peter J Crouch, David Pow, Terence Y Pang, Shanshan Li, Zoe M Smith, Paul S Francis, Thibault Renoir, Anthony J Hannan
Glutamatergic dysfunction has been implicated in the pathogenesis of depressive disorders and Huntington's disease (HD), in which depression is the most common psychiatric symptom. Synaptic glutamate homeostasis is regulated by cystine-dependent glutamate transporters, including GLT-1 and system xc(-) In HD, the enzyme regulating cysteine (and subsequently cystine) production, cystathionine-γ-lygase, has recently been shown to be lowered. The aim of the present study was to establish whether cysteine supplementation, using N-acetylcysteine (NAC) could ameliorate glutamate pathology through the cystine-dependent transporters, system xc(-) and GLT-1...
July 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27163208/synaptic-and-cellular-changes-induced-by-the-schizophrenia-susceptibility-gene-g72-are-rescued-by-n-acetylcysteine-treatment
#11
B Pósfai, C Cserép, P Hegedüs, E Szabadits, D M Otte, A Zimmer, M Watanabe, T F Freund, G Nyiri
Genetic studies have linked the primate-specific gene locus G72 to the development of schizophrenia and bipolar disorder. Transgenic mice carrying the entire gene locus express G72 mRNA in dentate gyrus (DG) and entorhinal cortex, causing altered electrophysiological properties of their connections. These transgenic mice exhibit behavioral alterations related to psychiatric diseases, including cognitive deficits that can be reversed by treatment with N-acetylcysteine, which was also found to be effective in human patients...
May 10, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27137430/n-acetylcysteine-in-depressive-symptoms-and-functionality-a-systematic-review-and-meta-analysis
#12
REVIEW
Brisa S Fernandes, Olivia M Dean, Seetal Dodd, Gin S Malhi, Michael Berk
OBJECTIVE: To assess the utility of N-acetylcysteine administration for depressive symptoms in subjects with psychiatric conditions using a systematic review and meta-analysis. DATA SOURCES: A computerized literature search was conducted in MEDLINE, Embase, the Cochrane Library, SciELO, PsycINFO, Scopus, and Web of Knowledge. No year or country restrictions were used. The Boolean terms used for the electronic database search were (NAC OR N-acetylcysteine OR acetylcysteine) AND (depression OR depressive OR depressed) AND (trial)...
April 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26900888/interventions-for-comorbid-problem-gambling-and-psychiatric-disorders-advancing-a-developing-field-of-research
#13
REVIEW
N A Dowling, S S Merkouris, F K Lorains
Despite significant psychiatric comorbidity in problem gambling, there is little evidence on which to base treatment recommendations for subpopulations of problem gamblers with comorbid psychiatric disorders. This mini-review draws on two separate systematic searches to identify possible interventions for comorbid problem gambling and psychiatric disorders, highlight the gaps in the currently available evidence base, and stimulate further research in this area. In this mini-review, only 21 studies that have conducted post-hoc analyses to explore the influence of psychiatric disorders or problem gambling subtypes on gambling outcomes from different types of treatment were identified...
July 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/26261019/n-acetylcysteine-prevents-stress-induced-anxiety-behavior-in-zebrafish
#14
Ricieri Mocelin, Ana P Herrmann, Matheus Marcon, Cassiano L Rambo, Aline Rohden, Fernanda Bevilaqua, Murilo Sander de Abreu, Leila Zanatta, Elaine Elisabetsky, Leonardo J G Barcellos, Diogo R Lara, Angelo L Piato
Despite the recent advances in understanding the pathophysiology of anxiety disorders, the pharmacological treatments currently available are limited in efficacy and induce serious side effects. A possible strategy to achieve clinical benefits is drug repurposing, i.e., discovery of novel applications for old drugs, bringing new treatment options to the market and to the patients who need them. N-acetylcysteine (NAC), a commonly used mucolytic and paracetamol antidote, has emerged as a promising molecule for the treatment of several neuropsychiatric disorders...
December 2015: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/25957927/clinical-trials-of-n-acetylcysteine-in-psychiatry-and-neurology-a-systematic-review
#15
REVIEW
Deepmala, John Slattery, Nihit Kumar, Leanna Delhey, Michael Berk, Olivia Dean, Charles Spielholz, Richard Frye
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. Over the past decade, there has been growing evidence for the use of NAC in treating psychiatric and neurological disorders, considering its role in attenuating pathophysiological processes associated with these disorders, including oxidative stress, apoptosis, mitochondrial dysfunction, neuroinflammation and glutamate and dopamine dysregulation. In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy...
August 2015: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/25937502/the-effects-of-n-acetylcysteine-and-or-deferoxamine-on-manic-like-behavior-and-brain-oxidative-damage-in-mice-submitted-to-the-paradoxal-sleep-deprivation-model-of-mania
#16
Camila O Arent, Samira S Valvassori, Amanda V Steckert, Wilson R Resende, Gustavo C Dal-Pont, Jéssica Lopes-Borges, Rafaela T Amboni, Guilherme Bianchini, João Quevedo
Bipolar disorder (BD) is a severe psychiatric disorder associated with social and functional impairment. Some studies have strongly suggested the involvement of oxidative stress in the pathophysiology of BD. Paradoxal sleep deprivation (PSD) in mice has been considered a good animal model of mania because it induces similar manic-like behavior, as well as producing the neurochemical alterations which have been observed in bipolar patients. Thus, the objective of the present study was to evaluate the effects of the antioxidant agent's n-acetylcysteine (Nac) and/or deferoxamine (DFX) on behavior and the oxidative stress parameters in the brains of mice submitted to the animal model of mania induced by PSD...
June 2015: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/25599341/cognitive-and-behavioural-aspects-of-prader-willi-syndrome
#17
REVIEW
Lauren J Rice, Stewart L Einfeld
PURPOSE OF REVIEW: To provide a review of the recent advances in the diagnosis and treatment of psychiatric disorders in Prader-Willi syndrome (PWS). RECENT FINDINGS: Research in the last 12 months has provided a descriptive prognosis of psychosis in PWS and highlighted the possible genes associated with the increased risk of psychosis for those with maternal uniparental disomy (mUPD). Several studies investigating social and communication skills have shown people with PWS to have difficulty with core, receptive and expressive language skills, interpreting emotional valence in faces, playing with children of their own age, understanding personal space and a developmental delay in the theory of mind...
March 2015: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/25580916/n-acetylcysteine-as-an-adjunctive-therapy-to-risperidone-for-treatment-of-irritability-in-autism-a-randomized-double-blind-placebo-controlled-clinical-trial-of-efficacy-and-safety
#18
RANDOMIZED CONTROLLED TRIAL
Mohammadali Nikoo, Hanieh Radnia, Mehdi Farokhnia, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: According to the proposed interference of N-acetylcysteine (NAC) with pathophysiologic processes of autistic disorders (ADs), we aimed to assess the effectiveness and safety of NAC as an adjunct to risperidone in the treatment of ADs in a randomized, double-blind, clinical trial. METHODS: The participants were referred outpatients between 4 and 12 years of age with the diagnosis of ADs and a score of more than 12 on Aberrant Behavior Checklist-Community (ABC-C) Irritability subscale score...
January 2015: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/25562842/n-acetylcysteine-improves-mitochondrial-function-and-ameliorates-behavioral-deficits-in-the-r6-1-mouse-model-of-huntington-s-disease
#19
D J Wright, T Renoir, Z M Smith, A E Frazier, P S Francis, D R Thorburn, S L McGee, A J Hannan, L J Gray
Huntington's disease (HD) is a neurodegenerative disorder, involving psychiatric, cognitive and motor symptoms, caused by a CAG-repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. Oxidative stress and excitotoxicity have previously been implicated in the pathogenesis of HD. We hypothesized that N-acetylcysteine (NAC) may reduce both excitotoxicity and oxidative stress through its actions on glutamate reuptake and antioxidant capacity. The R6/1 transgenic mouse model of HD was used to investigate the effects of NAC on HD pathology...
2015: Translational Psychiatry
https://www.readbyqxmd.com/read/25439852/-treatment-resistant-anxiety-disorders-a-literature-review-of-drug-therapy-strategies
#20
REVIEW
G Ammar, W J Naja, A Pelissolo
Anxiety disorders are widespread psychiatric conditions with significant social and professional disability, poor quality of life, an increased risk of suicide, and frequent attendance of medical services. Serotonin reuptake inhibitors (SRI) and serotonin and norepinephrine reuptake inhibitors (SNRI) have demonstrated a rather robust efficacy for the treatment of most of anxiety disorders. Nevertheless a substantial number of patients are resistant or still suffer from residual symptoms despite this first line treatment...
June 2015: L'Encéphale
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