Alessia Sarica, Antonio Cerasa, Paola Valentino, Jason Yeatman, Maria Trotta, Stefania Barone, Alfredo Granata, Rita Nisticò, Paolo Perrotta, Franco Pucci, Aldo Quattrone
This work evaluates the potential in diagnostic application of a new advanced neuroimaging method, which delineates the profile of tissue properties along the corticospinal tract (CST) in amyotrophic lateral sclerosis (ALS), by means of diffusion tensor imaging (DTI). Twenty-four ALS patients and twenty-four demographically matched healthy subjects were enrolled in this study. The Automated Fiber Quantification (AFQ), a tool for the automatic reconstruction of white matter tract profiles, based on a deterministic tractography algorithm to automatically identify the CST and quantify its diffusion properties, was used...
February 2017: Human Brain Mapping