keyword
https://read.qxmd.com/read/38510608/ntms-based-tractography-and-segmental-diffusion-analysis-in-patients-with-brainstem-gliomas-risk-stratification-and-clinical-potential
#1
JOURNAL ARTICLE
Lion Weiß, Fabia Roth, Pierre Rea-Ludmann, Tizian Rosenstock, Thomas Picht, Peter Vajkoczy, Anna Zdunczyk
INTRODUCTION: Surgery on the brainstem level is associated with a high-risk of postoperative morbidity. Recently, we have introduced the combination of navigated transcranial magnetic stimulation (nTMS) and diffusion tensor imaging (DTI) tractography to define functionally relevant motor fibers tracts on the brainstem level to support operative planning and risk stratification in brainstem cavernomas. RESEARCH QUESTION: Evaluate this method and assess it's clinical impact for the surgery of brainstem gliomas...
2024: Brain Spine
https://read.qxmd.com/read/38388254/the-hindbrain-and-cortico-reticular-pathway-in-adolescent-idiopathic-scoliosis
#2
JOURNAL ARTICLE
R C C Soh, B Z Chen, S Hartono, M S Lee, W Lee, S L Lim, J Gan, B Maréchal, L L Chan, Y L Lo
AIM: To characterise the corticoreticular pathway (CRP) in a case-control cohort of adolescent idiopathic scoliosis (AIS) patients using high-resolution slice-accelerated readout-segmented echo-planar diffusion tensor imaging (DTI) to enhance the discrimination of small brainstem nuclei in comparison to automated whole-brain volumetry and tractography and their clinical correlates. MATERIALS AND METHODS: Thirty-four participants (16 AIS patients, 18 healthy controls) underwent clinical and orthopaedic assessments and brain magnetic resonance imaging (MRI) on a 3 T MRI machine...
February 10, 2024: Clinical Radiology
https://read.qxmd.com/read/38021806/utility-of-diffusion-tensor-imaging-in-assessing-corticospinal-tracts-for-the-management-of-brain-tumors-a-cross-sectional-observational-study
#3
JOURNAL ARTICLE
Deepmala K Karmakar, Padma V Badhe, Pauras Mhatre, Shashwat Shrivastava, Moinuddin Sultan, Gautham Shankar, Khushboo Tekriwal, Swapnil Moharkar
Introduction Intra-axial brain tumors are a significant health problem and present several diagnostic and treatment challenges. Conventional magnetic resonance imaging (MRI) has posed several limitations, such as the inability to delineate the detailed anatomy of fibers in structures like the brainstem and the inability to accurately judge the extent of tumor infiltration. Diffusion tensor imaging (DTI), based on the concepts of isotropic and anisotropic diffusion, is capable of visualizing and segmenting white fiber bundles in high detail and providing crucial information about tumor boundaries, extent, neighboring tracts, and more...
October 2023: Curēus
https://read.qxmd.com/read/36896706/more-extensive-white-matter-disruptions-present-in-untreated-obstructive-sleep-apnea-than-we-thought-a-large-sample-diffusion-imaging-study
#4
JOURNAL ARTICLE
Dae Lim Koo, Ryan P Cabeen, Soon Hyun Yook, Steven Yong Cen, Eun Yeon Joo, Hosung Kim
Obstructive sleep apnea (OSA) may lead to white mater (WM) disruptions and cognitive deficits. However, no studies have investigated the full extent of the brain WM, and its associations with cognitive deficits in OSA remain unclear. We thus applied diffusion tensor imaging (DTI) tractography with multi-fiber models and used atlas-based bundle-specific approach to investigate the WM abnormalities for various tracts of the cerebral cortex, thalamus, brainstem, and cerebellum in patients with untreated OSA. We enrolled 100 OSA patients and 63 healthy controls...
March 10, 2023: Human Brain Mapping
https://read.qxmd.com/read/36720343/the-brainstem-connections-of-the-supplementary-motor-area-and-its-relations-to-the-corticospinal-tract-experimental-rat-and-human-3-tesla-tractography-study
#5
JOURNAL ARTICLE
Safiye Çavdar, Büşra Köse, Damlasu Altınöz, Mazhar Özkan, Yasin Celal Güneş, Oktay Algın
Although the supplementary motor area (SMA) is a large region on the medial surface of the frontal lobe of the brain, little is known about its function. The current study uses 3-tesla high-resolution diffusion tensor tractography (DTI) in healthy individuals and biotinylated dextran amine (BDA) and fluoro-gold (FG) tracer in rats to demonstrate the afferent and efferent connections of the SMA with brainstem structures. It also aims to clarify how SMA fibers relate to the corticospinal tract (CST). The BDA (n = 6) and FG (n = 8) tracers were pressure-injected into the SMA of 14 Wistar albino rats...
February 28, 2023: Neuroscience Letters
https://read.qxmd.com/read/36466162/clinical-factors-associated-with-microstructural-connectome-related-brain-dysmaturation-in-term-neonates-with-congenital-heart-disease
#6
JOURNAL ARTICLE
Jodie K Votava-Smith, Jenna Gaesser, Anna Lonyai Harbison, Vince Lee, Nhu Tran, Vidya Rajagopalan, Sylvia Del Castillo, S Ram Kumar, Elizabeth Herrup, Tracy Baust, Jennifer A Johnson, George C Gabriel, William T Reynolds, Julia Wallace, Benjamin Meyers, Rafael Ceschin, Cecilia W Lo, Vanessa J Schmithorst, Ashok Panigrahy
OBJECTIVE: Term congenital heart disease (CHD) neonates display abnormalities of brain structure and maturation, which are possibly related to underlying patient factors, abnormal physiology and perioperative insults. Our primary goal was to delineate associations between clinical factors and postnatal brain microstructure in term CHD neonates using diffusion tensor imaging (DTI) magnetic resonance (MR) acquisition combined with complementary data-driven connectome and seed-based tractography quantitative analyses...
2022: Frontiers in Neuroscience
https://read.qxmd.com/read/35785410/structural-magnetic-resonance-imaging-in-dystonia-a-systematic-review-of-methodological-approaches-and-findings
#7
REVIEW
Claire L MacIver, Chantal M W Tax, Derek K Jones, Kathryn J Peall
BACKGROUND AND PURPOSE: Structural magnetic resonance techniques have been widely applied in neurological disorders to better understand tissue changes, probing characteristics such as volume, iron deposition and diffusion. Dystonia is a hyperkinetic movement disorder, resulting in abnormal postures and pain. Its pathophysiology is poorly understood, with normal routine clinical imaging in idiopathic forms. More advanced tools provide an opportunity to identify smaller scale structural changes which may underpin pathophysiology...
November 2022: European Journal of Neurology
https://read.qxmd.com/read/35587724/surgical-treatment-of-brainstem-cavernomas-using-diffusion-tensor-imaging-and-diffusion-tensor-tractography
#8
JOURNAL ARTICLE
Krzysztof Majchrzak, Barbara Bobek-Billewicz, Anna Hebda, Piotr Ładziński
INTRODUCTION: The aims of this study were to assess the prognosis of patients after a single haemorrhage from the cavernoma, and also in the case of rehaemorrhage, and to determine the indications for surgical treatment of brainstem cavernomas. MATERIAL AND METHODS: The study included a group of 35 patients with brainstem cavernomas, 23 women and 12 men aged 27 to 57 years (mean age 38.4). Up to 2005, MRI perfusion-weighted imaging/diffusion-weighted imaging had been carried out in 13 surgically treated patients...
2022: Neurologia i Neurochirurgia Polska
https://read.qxmd.com/read/34715273/non-motor-connections-of-the-pedunculopontine-nucleus-of-the-rat-and-human-brain
#9
JOURNAL ARTICLE
Mazhar Özkan, Büşra Köse, Oktay Algın, Sinem Oğuz, Mert Emre Erden, Safiye Çavdar
INTRODUCTION: The connections of the pedunculopontine nucleus (PPN) with motor areas of the central nervous system (CNS) are well described in the literature, in contrast relations with non-motor areas are lacking. Thus, the aim of the present study is to define the non-motor connections of the PPN in rats using the fluoro-gold (FG) tracer and compare the presence of these connections in healthy human adults using diffusion tensor tractography (DTI). MATERIALS AND METHODS: We injected FG into the PPN of 12 rats...
January 10, 2022: Neuroscience Letters
https://read.qxmd.com/read/34674207/another-piece-of-the-puzzle-of-anomalous-connectivity-in-joubert-s-syndrome
#10
JOURNAL ARTICLE
Avner Meoded, Marcia Kukreja, Gunes Orman, Eugen Boltshauser, Thierry A G M Huisman
We report on the conventional and diffusion tensor imaging (DTI) findings of a 2-year-old child with clinical presentation of Joubert's Syndrome (JS) and brainstem structural abnormalities as depicted by neuroimaging.Conventional magnetic resonance imaging (MRI) showed a "molar tooth" configuration of the brainstem. A band-like formation coursing in an apparent axial plane anterior to the interpeduncular fossa was noted and appeared to partially cover the interpeduncular fossa.DTI maps and three-dimensional (3D) tractography demonstrated a prominent red-encoded white matter bundle anterior to the midbrain...
October 21, 2021: Neuropediatrics
https://read.qxmd.com/read/34335445/multicenter-prospective-analysis-of-hypertrophic-olivary-degeneration-following-infratentorial-stroke-hod-is-evaluation-of-disease-epidemiology-clinical-presentation-and-mr-imaging-aspects
#11
JOURNAL ARTICLE
Martin A Schaller-Paule, Eike Steidl, Manoj Shrestha, Ralf Deichmann, Helmuth Steinmetz, Alexander Seiler, Sriramya Lapa, Thorsten Steiner, Sven Thonke, Stefan Weidauer, Juergen Konczalla, Elke Hattingen, Christian Foerch
Introduction: Ischemic and hemorrhagic strokes in the brainstem and cerebellum with injury to the functional loop of the Guillain-Mollaret triangle (GMT) can trigger a series of events that result in secondary trans-synaptic neurodegeneration of the inferior olivary nucleus. In an unknown percentage of patients, this leads to a condition called hypertrophic olivary degeneration (HOD). Characteristic clinical symptoms of HOD progress slowly over months and consist of a rhythmic palatal tremor, vertical pendular nystagmus, and Holmes tremor of the upper limbs...
2021: Frontiers in Neurology
https://read.qxmd.com/read/34147690/clinical-application-of-diffusion-tensor-imaging-in-chiari-malformation-type-i-advances-and-perspectives-a-systematic-review
#12
JOURNAL ARTICLE
Lukasz Antkowiak, Marta Rogalska, Piotr Stogowski, Karolina Anuszkiewicz, Marek Mandera
BACKGROUND: Diffusion tensor imaging (DTI) application in Chiari malformation type I (CMI) is still poorly defined. This study aimed to systematically review the literature and propose perspectives toward the clinical application of DTI in CMI. METHODS: PubMed and Embase were searched for English-language articles published until October 20, 2020. Clinical studies and case series, evaluating fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), or radial diffusivity values in patients with CMI, were included...
August 2021: World Neurosurgery
https://read.qxmd.com/read/33386023/the-role-of-diffusion-tensor-imaging-and-tractography-in-the-surgical-management-of-brainstem-gliomas
#13
JOURNAL ARTICLE
Xiong Xiao, Lu Kong, Changcun Pan, Peng Zhang, Xin Chen, Tao Sun, Mingran Wang, Hui Qiao, Zhen Wu, Junting Zhang, Liwei Zhang
OBJECTIVE: Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) have the ability to noninvasively visualize changes in white matter tracts, as well as their relationships with lesions and other structures. DTI/DTT has been increasingly used to improve the safety and results of surgical treatment for lesions in eloquent areas, such as brainstem cavernous malformations. This study aimed to investigate the application value of DTI/DTT in brainstem glioma surgery and to validate the spatial accuracy of reconstructed corticospinal tracts (CSTs)...
January 2021: Neurosurgical Focus
https://read.qxmd.com/read/32069284/diffusion-tensor-tractography-of-brainstem-fibers-and-its-application-in-pain
#14
JOURNAL ARTICLE
Yu Zhang, Andrei A Vakhtin, Jennifer S Jennings, Payam Massaband, Max Wintermark, Patricia L Craig, J Wesson Ashford, J David Clark, Ansgar J Furst
Evaluation of brainstem pathways with diffusion tensor imaging (DTI) and tractography may provide insights into pathophysiologies associated with dysfunction of key brainstem circuits. However, identification of these tracts has been elusive, with relatively few in vivo human studies to date. In this paper we proposed an automated approach for reconstructing nine brainstem fiber trajectories of pathways that might be involved in pain modulation. We first performed native-space manual tractography of these fiber tracts in a small normative cohort of participants and confirmed the anatomical precision of the results using existing anatomical literature...
2020: PloS One
https://read.qxmd.com/read/31954337/anatomical-assessment-of-trigeminal-nerve-tractography-using-diffusion-mri-a-comparison-of-acquisition-b-values-and-single-and-multi-fiber-tracking-strategies
#15
COMPARATIVE STUDY
Guoqiang Xie, Fan Zhang, Laura Leung, Michael A Mooney, Lorenz Epprecht, Isaiah Norton, Yogesh Rathi, Ron Kikinis, Ossama Al-Mefty, Nikos Makris, Alexandra J Golby, Lauren J O'Donnell
BACKGROUND: The trigeminal nerve (TGN) is the largest cranial nerve and can be involved in multiple inflammatory, compressive, ischemic or other pathologies. Currently, imaging-based approaches to identify the TGN mostly rely on T2-weighted magnetic resonance imaging (MRI), which provides localization of the cisternal portion of the TGN where the contrast between nerve and cerebrospinal fluid (CSF) is high enough to allow differentiation. The course of the TGN within the brainstem as well as anterior to the cisternal portion, however, is more difficult to display on traditional imaging sequences...
2020: NeuroImage: Clinical
https://read.qxmd.com/read/31833430/white-matter-tracts-involved-by-deep-brain-stimulation-of-the-subthalamic-nucleus-in-parkinson-s-disease-a-connectivity-study-based-on-preoperative-diffusion-tensor-imaging-tractography
#16
JOURNAL ARTICLE
François Vassal, Domitille Dilly, Claire Boutet, Frédérique Bertholon, David Charier, Benjamin Pommier
Purpose: To depict the specific brain networks that are modulated by deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD), using diffusion tensor imaging-based fibre tractography (DTI-FT). Materials and methods: Nine patients who received bilateral STN-DBS for PD were included. Electrodes were localized by co-registering preoperative magnetic resonance imaging and postoperative computed tomography. The volume of tissue activated (VTA) was estimated as an isotropic, spherical electric field distribution centred at each effective electrode contact's centroid coordinates, taking into account individual stimulation parameters (i...
April 2020: British Journal of Neurosurgery
https://read.qxmd.com/read/31562962/eliciting-smiles-and-laughter-during-intraoperative-electric-stimulation-of-the-cingulum-surgical-scenario
#17
JOURNAL ARTICLE
Leticia Fernández, Carlos Santos, Elsa Gómez, Carlos Velásquez, Juan Martino
Laughter has a major role in daily social interactions; consequently, its biologic bases have been previously studied. Nevertheless, its cerebral representation remains unclear. The most accepted hypothesis has postulated that laughter has 2 components: mirth, related to the temporal and frontal neocortical areas, and motor aspect, related to the limbic system and brainstem. Furthermore, in prior studies, laughter has been elicited during electric stimulation with depth electrodes in the supplementary motor area and the cingulum...
January 2020: World Neurosurgery
https://read.qxmd.com/read/31440906/ventral-tegmental-area-connections-to-motor-and-sensory-cortical-fields-in-humans
#18
JOURNAL ARTICLE
Jonas A Hosp, V A Coenen, M Rijntjes, K Egger, H Urbach, C Weiller, M Reisert
In humans, sensorimotor cortical areas receive relevant dopaminergic innervation-although an anatomic description of the underlying fiber projections is lacking so far. In general, dopaminergic projections towards the cortex originate within the ventral tegmental area (VTA) and are organized in a meso-cortico-limbic system. Using a DTI-based global tractography approach, we recently characterized the superolateral branch of the medial forebrain bundle (slMFB), a prominent pathway providing dopaminergic (and other transmitters) innervation for the pre-frontal cortex (Coenen et al...
November 2019: Brain Structure & Function
https://read.qxmd.com/read/31360998/utility-of-a-quantitative-approach-using-diffusion-tensor-imaging-for-prognostication-regarding-motor-and-functional-outcomes-in-patients-with-surgically-resected-deep-intracranial-cavernous-malformations
#19
JOURNAL ARTICLE
Kumar Abhinav, Troels H Nielsen, Rhea Singh, Yingjie Weng, Summer S Han, Michael Iv, Gary K Steinberg
BACKGROUND: Resection of deep intracranial cavernous malformations (CMs) is associated with a higher risk of neurological deterioration and uncertainty regarding clinical outcomes. OBJECTIVE: To examine diffusion tractography imaging (DTI) data evaluating the corticospinal tract (CST) in relation to motor and functional outcomes in patients with surgically resected deep CMs. METHODS: Perilesional CST was characterized as disrupted, displaced, or normal...
May 1, 2020: Neurosurgery
https://read.qxmd.com/read/31355991/neurite-orientation-dispersion-and-density-imaging-quantifies-corticospinal-tract-microstructural-organization-in-children-with-unilateral-cerebral-palsy
#20
JOURNAL ARTICLE
Samuel T Nemanich, Bryon A Mueller, Bernadette T Gillick
Children with unilateral cerebral palsy (UCP) due to early brain injury exhibit disrupted connectivity of corticospinal tracts (CSTs), which can be quantified using diffusion-weighted magnetic resonance imaging (DWI). Diffusion tensor imaging (DTI) is commonly used to quantify white matter organization, however, this model lacks the biological specificity to accurately describe underlying microstructural properties. Newer approaches, such as neurite orientation dispersion and density imaging (NODDI), may provide more biologically accurate information regarding CST microstructure...
December 1, 2019: Human Brain Mapping
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