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DTI, tractography, brainstem

Da Li, Yu-Ming Jiao, Liang Wang, Fu-Xin Lin, Jun Wu, Xian-Zeng Tong, Shuo Wang, Yong Cao
OBJECTIVE Surgical management of brainstem lesions is challenging due to the highly compact, eloquent anatomy of the brainstem. This study aimed to evaluate the safety and efficacy of preoperative diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in brainstem cavernous malformations (CMs). METHODS A prospective randomized controlled clinical trial was performed by using stratified blocked randomization. The primary eligibility criterion of the study was being a surgical candidate for brainstem CMs (with informed consent)...
March 16, 2018: Journal of Neurosurgery
Daniel J Burkett, Jonathan R Garst, Jacquelyn P Hill, Anthony Kam, Douglas E Anderson
BACKGROUND AND PURPOSE: Pain information from the face enters the pons via the trigeminal nerve before creating an anatomical "elbow" that turns caudally into the spinal trigeminal tract (SpTV). Visualization of the descending tract of the trigeminal nerve as it begins its descent from the nerve root entry zone (NREZ) in the pons would improve the accuracy of current procedures aimed at altering or lesioning the trigeminal nerve within the brainstem. The focus of this study was to develop a standardized protocol using diffusion tensor imaging (DTI) and deterministic tractography methods to image the SpTV...
January 31, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Alessandro Arrigo, Enricomaria Mormina, Alessandro Calamuneri, Michele Gaeta, Silvia Marino, Demetrio Milardi, Giuseppe Pio Anastasi, Angelo Quartarone
The limbic system has a central role for the integration of several cognitive and visceral functions through an extended network of connections involving the hippocampus and the amygdala. A number of studies performed in humans have been dedicated to the investigation of supratentorial limbic pathways by means of non-invasive MRI approaches, such as DTI. However, detection of possible limbic connections involving the brainstem and the spinal cord is still missing. Subtentorial limbic pathways have been previously studied in animals by means of invasive approaches, including viral tracing...
February 20, 2017: Neuroscience
Alessia Sarica, Antonio Cerasa, Paola Valentino, Jason Yeatman, Maria Trotta, Stefania Barone, Alfredo Granata, Rita Nisticò, Paolo Perrotta, Franco Pucci, Aldo Quattrone
This work evaluates the potential in diagnostic application of a new advanced neuroimaging method, which delineates the profile of tissue properties along the corticospinal tract (CST) in amyotrophic lateral sclerosis (ALS), by means of diffusion tensor imaging (DTI). Twenty-four ALS patients and twenty-four demographically matched healthy subjects were enrolled in this study. The Automated Fiber Quantification (AFQ), a tool for the automatic reconstruction of white matter tract profiles, based on a deterministic tractography algorithm to automatically identify the CST and quantify its diffusion properties, was used...
February 2017: Human Brain Mapping
Joshua Dee Burks, Phillip A Bonney, Andrew K P Conner, Chad A Glenn, Robert G Briggs, Lillian B Boettcher, Daniel L OʼDonoghue, Dee H Wu, Michael Edward Sughrue
INTRODUCTION: The orbitofrontal cortex is understood to have a role in outcome evaluation and risk assessment, and is commonly involved by infiltrative tumors. A detailed understanding of the exact location and nature of associated white tracts could go far to prevent postoperative morbidity related to declining capacity. Through diffusion tensor imaging (DTI)-based fiber tracking validated by gross anatomical dissection as ground truth, we have characterized these connections based on relationships to other well-known structures...
August 2016: Neurosurgery
Jacob Januszewski, Lauren Albert, Karen Black, Amir R Dehdashti
BACKGROUND: Diffusion tensor imaging (DTI) estimates the course and connectivity patterns of white matter tracts. The objective of this study is to evaluate whether findings in the brain stem modify the preoperative surgical trajectory planning or postoperative outcome in patients with brain stem cavernous malformations. METHODS: Ten patients with symptomatic brainstem cavernous malformation underwent surgical resection. Five patients received preoperative DTI evaluation and the remaining 5 did not...
September 2016: World Neurosurgery
P M Iyer, A J Fagan, J F Meaney, N C Colgan, S D Meredith, D O Driscoll, K M Curran, D Bradley, J Redmond
BACKGROUND: Nystagmus in patients with multiple sclerosis (MS) is generally attributed to brainstem disease. Lesions in other regions may result in nystagmus. The identification of these other sites is enhanced by using 3-Tesla magnetic resonance imaging (3TMRI) due to increased signal-to-noise ratio. OBJECTIVE: We sought to evaluate the distribution of structural lesions and disruption of tracts in patients with horizontal nystagmus secondary to MS using 3TMRI...
November 2016: Irish Journal of Medical Science
L Delano-Wood, K J Bangen, S F Sorg, A L Clark, D M Schiehser, N Luc, M W Bondi, M Werhane, R T Kim, E D Bigler
We investigated associations between DTI indices of three brainstem white matter tracts, traumatic brain injury (TBI) injury characteristics, and postconcussive symptomatology (PCS) in a well-characterized sample of veterans with history of mild to moderate TBI (mTBI). 58 military veterans (mTBI: n = 38, mean age = 33.2, mean time since injury = 90.9 months; military controls [MC]; n = 20; mean age = 29.4) were administered 3T DTI scans as well as a comprehensive neuropsychiatric evaluation including evaluation of TBI injury characteristics and PCS symptoms (e...
September 2015: Brain Imaging and Behavior
Shuhei Yamada, Yoshiko Okita, Tomoko Shofuda, Ema Yoshioka, Masahiro Nonaka, Kosuke Mori, Shin Nakajima, Yonehiro Kanemura
BACKGROUND: Horizontal gaze palsy with progressive scoliosis (HGPPS) is an autosomal recessive disorder caused by mutations in the ROBO3 gene, resulting in a critical absence of crossing fibers in the brainstem. CASE PRESENTATION: We present a patient with ipsilateral hemiparesis caused by putaminal hemorrhage who had a history of horizontal gaze paralysis and scoliosis since childhood. Diffusion tensor imaging (DTI) tractography confirmed the presence of uncrossed corticospinal tracts...
2015: BMC Neurology
Yuqiang Yao, Nils H Ulrich, Roman Guggenberger, Yahea A Alzarhani, Helmut Bertalanffy, Spyros S Kollias
OBJECTIVE: In this study, we investigated the potential prognostic role of morphologic and quantitative diffusion tensor imaging (DTI) in patients with brainstem cavernoma (BSC) in terms of postoperative outcome. METHODS: In this retrospective study of 14 brainstem cavernoma patients, we analyzed pre- and postoperative DTI data. White matter tractography of corticospinal tracts (CSTs) was performed with the Fiber Assignment by Continuous Tracking algorithm, and morphologic characteristics of CSTs were compared with clinically assessed motor strength...
June 2015: World Neurosurgery
A K Håberg, A Olsen, K G Moen, K Schirmer-Mikalsen, E Visser, T G Finnanger, K A I Evensen, T Skandsen, A Vik, L Eikenes
This study examines how injury mechanisms and early neuroimaging and clinical measures impact white matter (WM) fractional anisotropy (FA), mean diffusivity (MD), and tract volumes in the chronic phase of traumatic brain injury (TBI) and how WM integrity in the chronic phase is associated with different outcome measures obtained at the same time. Diffusion tensor imaging (DTI) at 3 T was acquired more than 1 year after TBI in 49 moderate-to-severe-TBI survivors and 50 matched controls. DTI data were analyzed with tract-based spatial statistics and automated tractography...
July 2015: Journal of Neuroscience Research
Bruno C Flores, Anthony R Whittemore, Duke S Samson, Samuel L Barnett
OBJECT: Resection of brainstem cavernous malformations (BSCMs) may reduce the risk of stepwise neurological deterioration secondary to hemorrhage, but the morbidity of surgery remains high. Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are neuroimaging techniques that may assist in the complex surgical planning necessary for these lesions. The authors evaluate the utility of preoperative DTI and DTT in the surgical management of BSCMs and their correlation with functional outcome...
March 2015: Journal of Neurosurgery
Paul V Birinyi, Sarah Bieser, Martin Reis, Miguel A Guzman, Ashima Agarwal, Mohamed S Abdel-Baki, Samer K Elbabaa
We report a case of a four-year-old male who presented with symptoms of brainstem compression and lower cranial nerve neuropathies. MRI revealed a large, pre-pontine mass causing brainstem compression with an uncertain intra-axial component. Using diffusion tensor imaging (DTI) tractography and other imaging modalities, we were able to confirm that the lesion was extra-axial and did not involve the corticospinal tracts. In addition, DTI tractography illustrated that corticospinal tracts were displaced to the right obligating a left-sided approach...
March 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
M Marek, S Paus, N Allert, B Mädler, T Klockgether, H Urbach, V A Coenen
Focal lesions of brainstem, thalamus, and subcortical white matter may cause movement disorders that are clinically indistinguishable from cerebellar symptoms. It is suspected that ataxia in these cases is due to damage of efferent or afferent pathways of the cerebellum. However, the precise anatomical correlate often remains undefined. We used deterministic diffusion tensor magnetic resonance imaging (DTI) tractography to study the anatomical relationship between lesions causing ataxia and efferent cerebellar pathways...
January 2015: Journal of Neurology
Nils H Ulrich, Ralf A Kockro, David Bellut, Christina Amaxopoulou, Oliver Bozinov, Jan-Karl Burkhardt, Johannes Sarnthein, Spyros S Kollias, Helmut Bertalanffy
The spatial complexity of highly vulnerable structures makes surgical resection of brainstem cavernomas (BSC) a challenging procedure. Diffusion tensor imaging (DTI) allows for the visualization of white matter tracts and enables a better understanding of the anatomical location of corticospinal and sensory tracts before and after surgery.We investigated the feasibility and clinical usefulness of DTI-based fiber tractography in patients with BSC.Pre- and postoperative DTI visualization of corticospinal and sensory tracts were retrospectively analyzed in 23 individuals with BSC...
July 2014: Neurosurgical Review
O Phillips, F Squitieri, C Sanchez-Castaneda, F Elifani, A Griguoli, V Maglione, C Caltagirone, U Sabatini, M Di Paola
Huntington's disease (HD) is characterized by progressive motor impairment. Therefore, the connectivity of the corticospinal tract (CST), which is the main white matter (WM) pathway that conducts motor impulses from the primary motor cortex to the spinal cord, merits particular attention. WM abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using magnetic resonance imaging (MRI). In the present study, we examined CST microstructure using diffusion tensor imaging (DTI)-based tractography in 30-direction DTI data collected from 100 subjects: Pre-HD subjects (n = 25), HD patients (n = 25) and control subjects (n = 50), and T2*-weighted (iron sensitive) imaging...
September 2015: Cerebral Cortex
Yun Ju C Song, Mayuresh S Korgaonkar, Lucy V Armstrong, Sarah Eagles, Leanne M Williams, Stuart M Grieve
BACKGROUND: The brainstem is the main region that innervates neurotransmitter release to the Hypothalamic-Pituitary Adrenal (HPA) axis and fronto-limbic circuits, two key brain circuits found to be dysfunctional in Major Depressive Disorder (MDD). However, the brainstem's role in MDD has only been evaluated in limited reports. Using Diffusion Tensor Imaging (DTI), we investigated whether major brainstem white matter tracts that relate to these two circuits differ in MDD patients compared to healthy controls...
2014: PloS One
Soumen Khatua, Ping Hou, Ravi Bodiwala, Johannes Wolff, Jackson Hamilton, Shekhar Patil, Wafik Zaky, Anita Mahajan, Leena Ketonen
PURPOSE: The purpose of this study is to evaluate quantitative changes in diffusion tensor imaging (DTI) tractography and fractional anisotropy (FA) of the pons along with clinical correlation, in patients who receive re-irradiation for progressive diffuse intrinsic pontine glioma (DIPG). METHODS: A retrospective case review of children with progressive DIPG who received re-irradiation at our institution from 2007 to 2011 after approval from the Institutional Review Board was performed...
May 2014: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
S Treit, Z Chen, C Rasmussen, C Beaulieu
Inhibitory control and cognitive flexibility are two key executive functions that develop in childhood and adolescence, increasing one's capacity to respond dynamically to changing external demands and refrain from impulsive behaviors. These gains evolve in concert with significant brain development. Magnetic resonance imaging studies have identified numerous frontal and cingulate cortical areas associated with performance on inhibition tasks, but less is known about the involvement of the underlying anatomical connectivity, namely white matter...
September 12, 2014: Neuroscience
S Reimão, C Morgado, L Neto, J Ferreira, M Coelho, M Rosa, J Campos
The authors reviewed the diffusion tensor imaging (DTI) and tractography (DTT) of the normal brainstem and cerebellar white matter in normal volunteers, correlating it with structural magnetic resonance (MR) imaging and DTI data obtained in patients evaluated in our institution with movement disorders, including multisystem atrophy (MSA), spinocerebellar ataxia (SCA), progressive supra-nuclear palsy (PSP) and idiopathic Parkinson's disease (PD). DTI and tractography data demonstrated major white-matter fibers within the brain stem and cerebellum, including cortico-spinal tracts, transverse pontine fibers, medial lemniscus and cerebellar peduncles...
May 15, 2011: Neuroradiology Journal
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