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https://www.readbyqxmd.com/read/29157364/the-evolving-role-of-the-relationship-between-optic-nerve-structure-and-function-in-glaucoma
#1
Jithin Yohannan, Michael V Boland
The relationship between functional vision loss and structural changes of the optic nerve head and retinal ganglion cells is the hallmark of glaucoma diagnosis. Understanding and measuring this relationship has been the focus of numerous studies, the goal of which have been to improve glaucoma diagnosis and detection of glaucoma worsening. In this review, a historical perspective is used to understand structure-function relationships in glaucoma and their application to improve glaucoma diagnosis and monitoring...
December 2017: Ophthalmology
https://www.readbyqxmd.com/read/29146759/visual-field-indices-and-patterns-of-visual-field-deficits-in-mesopic-and-dark-adapted-two-colour-fundus-controlled-perimetry-in-macular-diseases
#2
Maximilian Pfau, Moritz Lindner, Julia S Steinberg, Sarah Thiele, Christian K Brinkmann, Monika Fleckenstein, Frank G Holz, Steffen Schmitz-Valckenberg
BACKGROUND/AIMS: To analyse the retest reliability of visual field indices and to describe patterns of visual field deficits in mesopic and dark-adapted two-colour fundus-controlled perimetry (FCP) in macular diseases. METHODS: Seventy-seven eyes (30 eyes with macular diseases and 47 normal eyes) underwent duplicate mesopic and dark-adapted two-colour FCP (Scotopic Macular Integrity Assessment, CenterVue). Non-weighted (mean defect, loss variance), variability-weighted (mean deviation, pattern standard deviation (PSD)) and graphical (cumulative defect (Bebie) curves) indices were computed...
November 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29135802/panretinal-photocoagulation-versus-ranibizumab-for-proliferative-diabetic-retinopathy-comparison-of-peripapillary-retinal-nerve-fiber-layer-thickness-in-a-randomized-clinical-trial
#3
Lee M Jampol, Isoken Odia, Adam R Glassman, Carl W Baker, Anjali M Bhorade, Dennis P Han, Glenn J Jaffe, Michele Melia, Neil M Bressler, Angelo P Tanna
PURPOSE: Compare changes in retinal nerve fiber layer (RNFL) thickness between eyes assigned to intravitreous ranibizumab or panretinal photocoagulation and assess correlations between changes in RNFL and visual field sensitivity and central subfield thickness. METHODS: Eyes with proliferative diabetic retinopathy were randomly assigned to ranibizumab or panretinal photocoagulation. Baseline and annual follow-up spectral domain optical coherence tomography RNFL imaging, optical coherence tomography macular imaging, and automated static perimetry (Humphrey visual field 60-4 algorithm) were performed...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29133651/comparison-of-30-2-standard-and-fast-programs-of-swedish-interactive-threshold-algorithm-of-humphrey-field-analyzer-for-perimetry-in-patients-with-intracranial-tumors
#4
Manav Deep Singh, Kanika Jain
PURPOSE: To find out whether 30-2 Swedish Interactive Threshold Algorithm (SITA) Fast is comparable to 30-2 SITA Standard as a tool for perimetry among the patients with intracranial tumors. METHODS: This was a prospective cross-sectional study involving 80 patients aged ≥18 years with imaging proven intracranial tumors and visual acuity better than 20/60. The patients underwent multiple visual field examinations using the two algorithms till consistent and repeatable results were obtained...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29119021/comparison-between-the-correlations-of-retinal-nerve-fiber-layer-thickness-measured-by-spectral-domain-optical-coherence-tomography-and-visual-field-defects-in-standard-automated-white-on-white-perimetry-versus-pulsar-perimetry
#5
Maged Alnawaiseh, Lisann Hömberg, Nicole Eter, Verena Prokosch
Purpose: To compare the structure-function relationships between retinal nerve fiber layer thickness (RNFLT) and visual field defects measured either by standard automated perimetry (SAP) or by Pulsar perimetry (PP). Materials and Methods: 263 eyes of 143 patients were prospectively included. Depending on the RNFLT, patients were assigned to the glaucoma group (group A: RNFL score 3-6) or the control group (group B: RNFL score 0-2). Structure-function relationships between RNFLT and mean sensitivity (MS) measured by SAP and PP were analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29116211/usefulness-of-10-2-matrix-frequency-doubling-technology-perimetry-for-detecting-central-visual-field-defects-in-preperimetric-glaucoma-patients
#6
Younhea Jung, Hae-Young L Park, Yi Ryeung Park, Chan Kee Park
It is generally acknowledged that structural loss can precede functional loss in some patients with early glaucoma. However, conventional standard automated perimetry (SAP) has limitations in the detection of functional loss, especially in the macular area. This study explores visual field loss in the macular areas of patients with preperimetric glaucoma exhibiting structural thinning in the area by examining the correlations between the ganglion cell-inner plexiform layer (GCIPL) and the results of matrix frequency-doubling technology (FDT) 10-2 tests...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114838/optical-coherence-tomography-angiography-macular-and-peripapillary-vessel-perfusion-density-in-healthy-subjects-glaucoma-suspects-and-glaucoma-patients
#7
COMPARATIVE STUDY
Giacinto Triolo, Alessandro Rabiolo, Nathan D Shemonski, Ali Fard, Federico Di Matteo, Riccardo Sacconi, Paolo Bettin, Stephanie Magazzeni, Giuseppe Querques, Luis E Vazquez, Piero Barboni, Francesco Bandello
Purpose: To evaluate macular and peripapillary vessel perfusion density (VD) in glaucoma suspects (GS) and glaucoma patients; to correlate ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thicknesses with macular and peripapillary VD; and to evaluate the diagnostic accuracy of the structural and vascular parameters. Methods: A consecutive series of GS, glaucoma patients, and healthy subjects was prospectively recruited from July 1, 2016, to January 31, 2017...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29094327/reduced-light-sensitivity-due-to-impaired-retinal-perfusion-in-branch-retinal-vein-occlusion
#8
Hiroyuki Iijima
PURPOSE: To study the reduction in light sensitivity in areas where impaired retinal perfusion was established by fluorescein angiogram (FA) in eyes with branch retinal vein occlusion (BRVO) that recovered from retinal edema and hemorrhage. DESIGN: Retrospective observational case series. METHODS: A study of the reduction in light sensitivity demonstrated by total deviation display of the Humphrey perimetry program 30-2 in 43 eyes from 42 patients with BRVO, whose perfusion status was assessed by FA images taken at least 6 months after disease onset...
November 1, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29084401/the-effect-of-a-decrease-in-intraocular-pressure-on-optic-nerve-function-in-patients-with-optic-nerve-drusen
#9
Dorota Pojda-Wilczek, Patrycja Wycisło-Gawron
PURPOSE: The aim of the study was to compare optic nerve function in eyes with brinzolamide-reduced intraocular pressure (IOP) and the fellow eyes of patients with optic disk drusen (ODD). METHODS: The study comprised 34 patients with bilateral ODD but no signs of any other ocular disease. The eyes with more advanced optic neuropathy were selected for treatment with an IOP-lowering drug, carbonic anhydrase inhibitor (brinzolamide); the fellow eyes served as the control...
October 31, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29082108/goldmann-v-standard-automated-perimetry-underestimates-central-visual-sensitivity-in-glaucomatous-eyes-with-increased-axial-length
#10
Mieko Yanagisawa, Hiroshi Murata, Masato Matsuura, Yuri Fujino, Kazunori Hirasawa, Ryo Asaoka
PURPOSE: To investigate the effect of axial length (AL) on the structure-function relationship between retinal nerve fiber layer (RNFL) thickness measurements and visual field (VF) sensitivity measured with Goldmann III and V. METHOD: There were 85 eyes of 85 patients with primary open angle glaucoma included in the current study. Optical coherence tomography and VF (Humphrey Field Analyzer 24-2 or 30-2) measurements with Goldmann III and V targets were carried out in all patients...
October 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29077730/detection-of-central-visual-field-defects-in-early-glaucomatous-eyes-comparison-of-humphrey-and-octopus-perimetry
#11
Gloria Roberti, Gianluca Manni, Ivano Riva, Gabor Holló, Luciano Quaranta, Luca Agnifili, Michele Figus, Sara Giammaria, Davide Rastelli, Francesco Oddone
PURPOSE: To compare the detection rate of central visual field defect (CVFD) between the 30-degree Octopus G1 program (Dynamic strategy) and the HFA 10-2 SITA-Standard test in early glaucoma eyes not showing any CVFD on the HFA 24-2 SITA-Standard test. METHODS: One eye of 41 early glaucoma patients without CVFD in the central 10° on HFA 24-2 test was tested with both the HFA 10-2 test and the Octopus G1 program 15 minutes apart, in random order. The primary outcome measure was the comparison of CVFD detection rates...
2017: PloS One
https://www.readbyqxmd.com/read/29074494/phenotypic-diversity-in-autosomal-dominant-cone-rod-dystrophy-elucidated-by-adaptive-optics-retinal-imaging
#12
Hongxin Song, Ethan A Rossi, Edwin Stone, Lisa Latchney, David Williams, Alfredo Dubra, Mina Chung
PURPOSE: Several genes causing autosomal-dominant cone-rod dystrophy (AD-CRD) have been identified. However, the mechanisms by which genetic mutations lead to cellular loss in human disease remain poorly understood. Here we combine genotyping with high-resolution adaptive optics retinal imaging to elucidate the retinal phenotype at a cellular level in patients with AD-CRD harbouring a defect in the GUCA1A gene. METHODS: Nine affected members of a four-generation AD-CRD pedigree and three unaffected first-degree relatives underwent clinical examinations including visual acuity, fundus examination, Goldmann perimetry, spectral domain optical coherence tomography and electroretinography...
October 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29071374/wagner-syndrome-anatomic-functional-and-genetic-characterization-of-a-portuguese-family
#13
Joana R Araújo, João Tavares-Ferreira, Sérgio Estrela-Silva, Paulo Rocha, Elisete Brandão, Pedro Alves Faria, Fernando Falcão-Reis, Amândio Rocha-Sousa
PURPOSE: To report the clinical (anatomic and functional) and genetic findings of Wagner Syndrome (WS) in a Portuguese family. METHODS: Nine members of the family agreed to be examined. All had complete clinical eye examinations. The proband and selected patients underwent color fundus photography, spectral domain optical coherence tomography (SD-OCT), automatic static white-on-white computerized perimetry, and electrophysiology assessment (flash ERG, multifocal(mf) ERG and dark adaptometry)...
October 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29062776/evaluation-of-refractive-correction-for-standard-automated-perimetry-in-eyes-wearing-multifocal-contact-lenses
#14
Kazunori Hirasawa, Hikaru Ito, Yukari Ohori, Yui Takano, Nobuyuki Shoji
AIM: To evaluate the refractive correction for standard automated perimetry (SAP) in eyes with refractive multifocal contact lenses (CL) in healthy young participants. METHODS: Twenty-nine eyes of 29 participants were included. Accommodation was paralyzed in all participants with 1% cyclopentolate hydrochloride. SAP was performed using the Humphrey SITA-standard 24-2 and 10-2 protocol under three refractive conditions: monofocal CL corrected for near distance (baseline); multifocal CL corrected for distance (mCL-D); and mCL-D corrected for near vision using a spectacle lens (mCL-N)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29062772/structure-function-relationship-comparison-between-retinal-nerve-fibre-layer-and-bruch-s-membrane-opening-minimum-rim-width-in-glaucoma
#15
Lukas Reznicek, Sophie Burzer, Andrea Laubichler, Ali Nasseri, Chris P Lohmann, Nikolaus Feucht, Michael Ulbig, Mathias Maier
AIM: To evaluate and compare structural optical coherence tomography (OCT)-based parameters, such as Bruch's membrane opening-minimum rim width (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness in glaucoma patients with visual field (VF) defects, and to correlate both to mean deviation (MD) values of obtained standard achromatic perimetry (SAP) examinations. METHODS: Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29060564/detecting-impaired-vision-caused-by-amd-from-gaze-data
#16
Huiying Liu, Yanwu Xu, Damon Wong, Ai Ping Yow, Augustinus Laude, Tock Han Lim
Age Related Macular Degeneration (AMD) is the third leading cause of blindness and the first one in the elderly. AMD usually causes central blindness due to loss of photoreceptor cell . In this paper, we propose to detect AMD caused vision impairment from gaze data. Compared with the current methods, e.g., Amsler grid, Microperimetry and Preferential Hyperacuity Perimetry, to detect vision impairments, the proposed method has several advantages. 1) It does not require the patient to stare at a fixed position throughout the test...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29046828/exploring-test-retest-variability-using-high-resolution-perimetry
#17
Takuya Numata, Ted Maddess, Chota Matsumoto, Sachiko Okuyama, Shigeki Hashimoto, Hiroki Nomoto, Yoshikazu Shimomura
PURPOSE: Test-retest variability (TRV) of visual field (VF) data seriously degrades our capacity to recognize true VF progression. We conducted repeated high-resolution perimetry with a test interval of 0.5° to investigate the sources of TRV. In particular, we examined whether the spatial variance of the observed sensitivity changes or if their absolute magnitude was of more importance. METHODS: Sixteen eyes of 16 glaucoma patients were each tested three times at 61 VF locations along the superior-temporal 45° meridian using a modified protocol of the Octopus 900 perimeter...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29045331/test-conditions-in-macular-visual-field-testing-in-glaucoma
#18
Mariko Eura, Chota Matsumoto, Shigeki Hashimoto, Sachiko Okuyama, Sonoko Takada, Hiroki Nomoto, Fumi Tanabe, Yoshikazu Shimomura
PURPOSE: To evaluate the suitable visual field (VF) test conditions (target size, test type, and eccentricity) for the macular region, we investigated the correlations between the ganglion cell layer (GCL) thickness and six VF test results. METHODS: We tested 32 eyes of patients (61.1±9.2 y) with preperimetric (6), early-stage (16), and moderate-stage (10) glaucoma. The VF tests included 3 SAP (the 10-2 HFA using SITA with target size III [HFA SITA (III)], full threshold with size III [HFA FULL (III)] and size I [HFA FULL (I)]) and 3 visual function-specific perimetry tests (the 10-2 SWAP, 10-2 flicker, and 10-2 Humphrey Matrix)...
October 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29044065/the-adverse-effects-of-valproic-acid-on-visual-functions-in-the-treatment-of-retinitis-pigmentosa
#19
Yüksel Totan, Emre Güler, Aslıhan Yüce, Mehmet Serdar Dervişogulları
PURPOSE: To evaluate the efficacy and safety of valproic acid (VPA) treatment in patients with retinitis pigmentosa (RP). METHODS: A total of 48 eyes of 24 patients (13 males, 11 females) with RP prescribed VPA were included. The length of VPA treatment was 6-12 months (mean 9.4 months). Parameters evaluated were best-corrected visual acuity (BCVA) (logarithm of the minimum angle of resolution [logMAR]), visual field analyses (VFAs) with Humprey automated perimetry, multifocal electroretinography (ERG) with Roland-RETI scan, and VPA side effects...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044061/long-term-scanning-laser-ophthalmoscopy-and-perimetry-in-different-severities-of-primary-open-and-chronic-angle-closure-glaucoma-eyes
#20
Ramanjit Sihota, Aparna Rao, Geetha Srinivasan, Viney Gupta, Ajay Sharma, Tanuj Dada, M Kalaiwani
PURPOSE: To determine rate of change over time on scanning laser ophthalmoscopy, HRT, compared to perimetry, and to determine incidence, parametric changes, and risk factors for progression in primary open angle glaucoma (POAG) and chronic primary angle closure angle glaucoma (CPACG) eyes. METHODS: Prospective clinical study of 116 POAG eyes and 129 CPACG eyes of different severities of glaucoma. Standard automated perimetry and optic nerve head topography were studied at baseline and thereafter every 6 months...
October 2017: Indian Journal of Ophthalmology
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