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Physiological Profile Assessment

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https://www.readbyqxmd.com/read/28430792/the-influence-of-sagittal-profile-alteration-and-final-lordosis-on-the-clinical-outcome-of-cervical-spondylotic-myelopathy-a-delta-omega-analysis
#1
Daniel Koeppen, Claudia Piepenbrock, Stefan Kroppenstedt, Mario Čabraja
PURPOSE: Decompression and maintaining or restoring a cervical lordosis are major goals in the surgical treatment of cervical spondylotic myelopathy (CSM). Numerous studies support the assumption that cervical lordosis is a key factor for neurological recovery and pain reduction. However, even kyphotic patients can be asymptomatic. The balance of the spine is subject of an increasing number of publications. The main purpose of the study was to evaluate the validity of lordotic alignment on the course of CSM and to set this parameter in context with well-validated tools, namely the modified Japanese Orthopaedic Association scoring system (mJOAS) and the visual analogue scale (VAS), to predict and measure the clinical outcome after surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28423063/vitamin-d-status-and-its-association-with-insulin-resistance-among-type-2-diabetics-a-case-control-study-in-ghana
#2
Linda Ahenkorah Fondjo, William K B A Owiredu, Samuel Asamoah Sakyi, Edwin Ferguson Laing, Michael Acquaye Adotey-Kwofie, Enoch Odame Antoh, Eric Detoh
BACKGROUND: Vitamin D plays a major role in physiological processes that modulate mineral metabolism and immune function with probable link to several chronic and infectious conditions. Emerging data suggests a possible influence of vitamin D on glucose homeostasis. This study sought to provide preliminary information on vitamin D status among Ghanaian type 2 diabetics and assessed its association with glucose homeostasis. METHODS: In a case control study, 118 clinically diagnosed Type 2 Diabetes Mellitus (T2DM) patients attending Diabetic Clinic at the Nkawie Government Hospital were enrolled between October and December 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28421101/hyperspectral-technologies-for-assessing-seed-germination-and-trifloxysulfuron-methyl-response-in-amaranthus-palmeri-palmer-amaranth
#3
Maor Matzrafi, Ittai Herrmann, Christian Nansen, Tom Kliper, Yotam Zait, Timea Ignat, Dana Siso, Baruch Rubin, Arnon Karnieli, Hanan Eizenberg
Weed infestations in agricultural systems constitute a serious challenge to agricultural sustainability and food security worldwide. Amaranthus palmeri S. Watson (Palmer amaranth) is one of the most noxious weeds causing significant yield reductions in various crops. The ability to estimate seed viability and herbicide susceptibility is a key factor in the development of a long-term management strategy, particularly since the misuse of herbicides is driving the evolution of herbicide response in various weed species...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28418107/a-new-path-in-defining-light-parameters-for-hair-growth-discovery-and-modulation-of-photoreceptors-in-human-hair-follicle
#4
Serena Buscone, Andrei N Mardaryev, Bianca Raafs, Jan W Bikker, Carsten Sticht, Norbert Gretz, Nilofer Farjo, Natallia E Uzunbajakava, Natalia V Botchkareva
BACKGROUND AND OBJECTIVE: Though devices for hair growth based on low levels of light have shown encouraging results, further improvements of their efficacy is impeded by a lack of knowledge on the exact molecular targets that mediate physiological response in skin and hair follicle. The aim of this study was to investigate the expression of selected light-sensitive receptors in the human hair follicle and to study the impact of UV-free blue light on hair growth ex vivo. MATERIAL AND METHODS: The expression of Opsin receptors in human skin and hair follicles has been characterized using RT-qPCR and immunofluorescence approaches...
April 18, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28414516/effects-of-having-preterm-infants-smell-amniotic-fluid-mother-s-milk-and-mother-s-odor-during-heel-stick-procedure-on-pain-physiological-parameters-and-crying-duration
#5
Dilek Küçük Alemdar, Funda Kardaş Özdemir
OBJECTIVE: The study aims to assess effects of having preterm infants smell amniotic fluid, mother's milk, and mother's odor during heel stick procedure on pain, physiological parameters, and crying duration. MATERIALS AND METHODS: The study was a randomized controlled experimental research. The population of the study was made up of preterm infants receiving treatment and care at a neonatal intensive care unit, where the study was conducted between January 2015 and March 2016...
April 17, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28411280/interrelationships-between-infliximab-and-rhtnf-%C3%AE-in-plasma-using-minimal-physiologically-based-pharmacokinetic-mpbpk-models
#6
Xi Chen, Debra C DuBois, Richard R Almon, William J Jusko
The soluble cytokine TNF-α is an important target for many therapeutic proteins used in the treatment of rheumatoid arthritis (RA). Biologics targeting TNF-α exert their pharmacological effects through binding and neutralizing this cytokine and preventing it from binding to its cell surface receptors. The magnitude of their pharmacological effects directly corresponds to the extent and duration of free TNF-α suppression. However, endogenous TNF-α is of low abundance and therefore it is quite challenging to assess the free TNF-α suppression experimentally...
April 14, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28408807/comparison-of-oral-health-related-quality-of-life-of-patients-treated-by-palatal-expanders-with-patients-treated-by-fixed-orthodontic-appliances
#7
Mariana A Alghamdi, Nada J Farsi, Ali H Hassan
INTRODUCTION AND PURPOSE: Wearing orthodontic appliances may negatively affect a patient's oral health-related quality of life (OHRQoL) physiologically, psychologically, and socially. Few studies have assessed the effect of palatal expanders on OHRQoL. The aim of this study was to evaluate the impact of palatal expanders on OHRQoL and to compare it with that of fixed orthodontic appliances. MATERIALS AND METHODS: All adolescent and adult orthodontic patients who were undergoing treatment with fixed appliances or palatal expanders between July 2015 and January 2016 in King Abdulaziz University Orthodontc Dental Clinics, were recruited (n=399)...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28407291/use-of-contrast-media-in-computed-tomography-and-magnetic-resonance-imaging-in-horses-techniques-adverse-events-and-opportunities
#8
REVIEW
B B Nelson, L R Goodrich, M F Barrett, M W Grinstaff, C E Kawcak
The use of contrast media in computed tomography (CT) and magnetic resonance imaging (MRI) is increasing in horses. These contrast-enhanced imaging techniques provide improved tissue delineation and evaluation thereby expanding diagnostic capabilities. While generally considered safe, not all contrast media exhibit the same safety profiles. The safety of contrast media use and descriptions of adverse events occurring in horses are sparsely reported. This review summarises the reported evidence of contrast media use and adverse events that occur in horses, with added contribution from other veterinary species and human studies for comparison...
April 13, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28406361/predictors-of-performance-in-a-4-h-mountain-bike-race
#9
Andrew R Novak, Kyle J M Bennett, Job Fransen, Ben J Dascombe
This study aimed to cross validate previously developed predictive models of mountain biking performance in a new cohort of mountain bikers during a 4-h event (XC4H). Eight amateur XC4H cyclists completed a multidimensional assessment battery including a power profile assessment that consisted of maximal efforts between 6 and 600 s, maximal hand grip strength assessments, a video-based decision-making test as well as a XC4H race. A multiple linear regression model was found to predict XC4H performance with good accuracy (R(2) = 0...
April 13, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28400722/sex-differences-in-the-physiological-and-behavioral-effects-of-chronic-oral-methylphenidate-treatment-in-rats
#10
Lisa S Robison, Michalis Michaelos, Jason Gandhi, Dennis Fricke, Erick Miao, Chiu-Yim Lam, Anthony Mauceri, Melissa Vitale, Junho Lee, Soyeh Paeng, David E Komatsu, Michael Hadjiargyrou, Panayotis K Thanos
Methylphenidate (MP) is a psychostimulant prescribed for Attention Deficit Hyperactivity Disorder. Previously, we developed a dual bottle 8-h-limited-access-drinking-paradigm for oral MP treatment of rats that mimics the pharmacokinetic profile of treated patients. This study assessed sex differences in response to this treatment. Male and female Sprague Dawley rats were assigned to one of three treatment groups at 4 weeks of age (n = 12/group): Control (water), low dose (LD) MP, and high dose (HD) MP. Rats drank 4 mg/kg MP (LD) or 30 mg/kg MP (HD) during the first hour, and 10 mg/kg (LD) or 60 mg/kg MP (HD) for the remaining 7 h each day...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28396085/electrophoretically-mediated-microanalysis-for-simultaneous-on-capillary-derivatization-of-standard-amino-acids-followed-by-micellar-electrokinetic-capillary-chromatography-with-laser-induced-fluorescence-detection
#11
Andrea Celá, Aleš Mádr, Zdeněk Glatz
Amino acids are crucial compounds involved in most biochemical processes essential for life. Since their dynamic turnover reflects the actual physiology of the cell/organism, a turnover assessment may provide valuable information related to multiple physiological and pathophysiological conditions. The sensitive determination of amino acids is predominantly associated with their derivatization which might be laborious, time-consuming and difficult to standardize. However, capillary electrophoresis offers the automatic injection and mixing of reactants, incubation of the reaction mixture, separation and detection of the reaction products in one on-capillary procedure...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28388793/treating-the-deviated-or-wide-nasal-dorsum
#12
Richard E Davis, Allen I Foulad
Both deviation and excessive width of the nasal dorsum result in conspicuous facial disharmony and are often attended by nasal airway dysfunction. Whether the result of developmental growth disturbances, nasal trauma, failed nasal surgery, or combinations therein, deviation and splaying of the nasal dorsum can be exceedingly difficult to treat. Individualized treatment is paramount because contour variations are seemingly endless, and a careful preoperative assessment of the anatomic, physiologic, cosmetic, and psychosocial factors that characterize the deformity is necessary to devise an effective patient-specific treatment plan...
April 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28388245/affect-and-sexual-responsivity-in-men-with-and-without-a-history-of-sexual-aggression
#13
Amber N Craig, Zoë D Peterson, Erick Janssen, David Goodrich, Julia R Heiman
Despite increased attention to understanding risk factors for sexual aggression, knowledge regarding the emotional and sexual arousal patterns of sexually aggressive men remains limited. The current study examined whether sexually aggressive men exhibit unique profiles of affective responsivity, in particular to negatively valenced stimuli, as well as sexual arousal patterns that differentiate them from nonaggressive men. We presented 78 young men (38 sexually aggressive; 40 nonaggressive) with a series of videos designed to induce positive, sad, or anxious affect...
April 7, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28387583/analytical-ultracentrifugation-with-fluorescence-detection-system-reveals-differences-in-complex-formation-between-recombinant-human-tnf-and-different-biological-tnf-antagonists-in-various-environments
#14
Elena Krayukhina, Masanori Noda, Kentaro Ishii, Takahiro Maruno, Hirotsugu Wakabayashi, Minoru Tada, Takuo Suzuki, Akiko Ishii-Watabe, Masahiko Kato, Susumu Uchiyama
A number of studies have attempted to elucidate the binding mechanism between tumor necrosis factor (TNF) and clinically relevant antagonists. None of these studies, however, have been conducted as close as possible to physiologic conditions, and so the relationship between the size distribution of TNF-antagonist complexes and the antagonists' biological activity or adverse effects remains elusive. Here, we characterized the binding stoichiometry and sizes of soluble TNF-antagonist complexes for adalimumab, infliximab, and etanercept that were formed in human serum and in phosphate-buffered saline (PBS)...
March 3, 2017: MAbs
https://www.readbyqxmd.com/read/28386566/irisin-a-potential-link-between-physical-exercise-and-metabolism-an-observational-study-in-differently-trained-subjects-from-elite-athletes-to-sedentary-people
#15
Stefano Benedini, Elena Dozio, Pietro Luigi Invernizzi, Elena Vianello, Giuseppe Banfi, Ileana Terruzzi, Livio Luzi, Massimiliano Marco Corsi Romanelli
We compared irisin levels among groups of differently trained healthy individuals to explore the role of irisin as a physiological linker between exercise and metabolic health. Irisin and biochemical parameters of glucose and lipid metabolism were assessed in 70 healthy volunteers stratified for sport performance level into four groups: (1) 20 elite athletes of national level, (2) 20 subelite athletes of local level, (3) 20 recreational athletes, and (4) 10 sedentary subjects. All biochemical parameters were within the ranges of normality...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28384419/are-invasive-species-stressful-the-glucocorticoid-profile-of-native-lizards-exposed-to-invasive-fire-ants-depends-on-the-context
#16
Sean P Graham, Nicole A Freidenfelds, Christopher J Thawley, Travis R Robbins, Tracy Langkilde
Invasive species represent a substantial threat to native species worldwide. Research on the impacts of invasive species on wild living vertebrates has focused primarily on population-level effects. The sublethal, individual-level effects of invaders may be equally important but are poorly understood. We investigated the effects of invasive fire ants (Solenopsis invicta) on the physiological stress response of a native lizard (Sceloporus undulatus) within two experimental contexts: directly exposing lizards to a fire ant attack and housing lizards with fire ants in seminatural field enclosures...
May 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28378146/use-of-a-highly-parallel-microfluidic-flow-cell-array-to-determine-therapeutic-drug-dose-response-curves
#17
Jesús A Arellano, Taylor A Howell, James Gammon, Sungpil Cho, Margit M Janát-Amsbury, Bruce Gale
A high-throughput, microfluidic flow cell array (MFCA) system has been modified to enable drug screening against small-volume cell-, and tissue cultures. The MFCA is composed of a 3D channel network that simultaneously flows fluids through forty-eight 830 μm by 500 μm flow cells, which physically divide and fluidically seal an existing culture into multiple compartments when docked onto the surface of a cell or tissue culture dish. The modified system provides temperature (37 °C) and CO2/pH level controls, while continuously flowing solutions (media or other liquid such as drug suspensions) over the cells/tissues...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28376914/suppression-of-laccase-2-severely-impairs-cuticle-tanning-and-pathogen-resistance-during-the-pupal-metamorphosis-of-anopheles-sinensis-diptera-culicidae
#18
Ming-Hui Du, Zheng-Wen Yan, You-Jin Hao, Zhen-Tian Yan, Feng-Ling Si, Bin Chen, Liang Qiao
BACKGROUND: Phenol oxidases (POs) catalyze the oxidation of dopa and dopamine to melanin, which is crucial for cuticle formation and innate immune maintenance in insects. Although, Laccase 2, a member of the PO family, has been reported to be a requirement for melanin-mediated cuticle tanning in the development stages of some insects, whether it participates in cuticle construction and other physiological processes during the metamorphosis of mosquito pupae is unclear. METHODS: The association between the phenotype and the expression profile of Anopheles sinensis Laccase 2 (AsLac2) was assessed from pupation to adult eclosion...
April 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28376835/indoor-air-pollution-and-its-association-with-poor-lung-function-microalbuminuria-and-variations-in-blood-pressure-among-kitchen-workers-in-india-a-cross-sectional-study
#19
Amarnath Singh, Chandrasekharan Nair Kesavachandran, Ritul Kamal, Vipin Bihari, Afzal Ansari, Parappurath Abdul Azeez, Prem Narain Saxena, Anil Kumar Ks, Altaf Hussain Khan
BACKGROUND: The present study is an attempt to explore the association between kitchen indoor air pollutants and physiological profiles in kitchen workers with microalbuminuria (MAU) in north India (Lucknow) and south India (Coimbatore). METHODS: The subjects comprised 145 control subjects, 233 kitchen workers from north India and 186 kitchen workers from south India. Information related to the personal and occupational history and health of the subjects at both locations were collected using a custom-made questionnaire...
April 4, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28373106/umbilical-cord-blood-androgen-levels-in-girls-and-boys-assessed-by-gas-chromatography-tandem-mass-spectrometry
#20
Anna-Carin Lundell, Henrik Ryberg, Liesbeth Vandenput, Anna Rudin, Claes Ohlsson, Åsa Tivesten
Androgen exposure of the fetus during gestation plays an important role in human physiology and pathophysiology, but assessment of androgens, in particular dihydrotestosterone (DHT), in human umbilical cord blood is technically challenging. The aim of this study was to assess umbilical cord androgen levels, including DHT, at birth by a highly sensitive assay, and study their association with sex of the infant, sex-hormone-binding globulin (SHBG) levels, and gestational age at delivery. Swedish infants (27 girls, 26 boys) were recruited at maternity care clinics in Southern Sweden...
March 31, 2017: Journal of Steroid Biochemistry and Molecular Biology
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