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Physiological Profile Assessment

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https://www.readbyqxmd.com/read/29348485/motor-signatures-of-emotional-reactivity-in-frontotemporal-dementia
#1
Charles R Marshall, Chris J D Hardy, Lucy L Russell, Camilla N Clark, Rebecca L Bond, Katrina M Dick, Emilie V Brotherhood, Cath J Mummery, Jonathan M Schott, Jonathan D Rohrer, James M Kilner, Jason D Warren
Automatic motor mimicry is essential to the normal processing of perceived emotion, and disrupted automatic imitation might underpin socio-emotional deficits in neurodegenerative diseases, particularly the frontotemporal dementias. However, the pathophysiology of emotional reactivity in these diseases has not been elucidated. We studied facial electromyographic responses during emotion identification on viewing videos of dynamic facial expressions in 37 patients representing canonical frontotemporal dementia syndromes versus 21 healthy older individuals...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29344797/annular-dynamics-of-memo3d-annuloplasty-ring-evaluated-by-3d-transesophageal-echocardiography
#2
Hiroyuki Nishi, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Satsuki Fukushima, Daisuke Yoshioka, Yoshiki Sawa
BACKGROUND: We assessed the mitral annular motion after mitral valve repair with the Sorin Memo 3D® (Sorin Group Italia S.r.L., Saluggia, Italy), which is a unique complete semirigid annuloplasty ring intended to restore the systolic profile of the mitral annulus while adapting to the physiologic dynamism of the annulus, using transesophageal real-time three-dimensional echocardiography. METHODS: 17 patients (12 male; mean age 60.4 ± 14.9 years) who underwent mitral annuloplasty using the Memo 3D ring were investigated...
January 17, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29341824/intestinal-lymph-as-a-readout-of-meal-induced-glp-1-release-in-an-unrestrained-rat-model
#3
Nino Jejelava, Sharon Kaufman, Jean-Philippe Krieger, Marcella Martins Terra, Wolfgang Langhans, Myrtha Arnold
Intestinal lymph supposedly provides a readout for the secretion of intestinal peptides. We here assessed how mesenteric lymph duct (MLD) lymph levels of glucagon-like peptide (GLP-1), insulin, and metabolites (Glucose, triglycerides [TG]) evolve after isocaloric high and low fat diet (HFD, LFD) meals, and how they compare to hepatic portal vein (HPV) plasma levels. Moreover, we examined the effects of intraperitoneally (IP) administered GLP-1 (1 or 10 nmol/kg) on these parameters. At 20 min after the HFD meal onset, GLP-1 levels were higher in MLD lymph than in HPV plasma...
January 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29336308/clinical-significance-of-concordance-or-discordance-between-fractional-flow-reserve-and-coronary-flow-reserve-for-coronary-physiological-indices-microvascular-resistance-and-prognosis-after-elective-percutaneous-coronary-intervention
#4
Eisuke Usui, Tadashi Murai, Yoshihisa Kanaji, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Rikuta Hamaya, Yoshinori Kanno, Tetsumin Lee, Taishi Yonetsu, Tsunekazu Kakuta
AIMS: We aimed to investigate the impact of concordance or discordance of fractional flow reserve (FFR) and coronary flow reserve (CFR) on coronary flow profiles and microvascular resistance after percutaneous coronary intervention (PCI), and the prognostic impact of the periprocedural physiological indices. METHODS AND RESULTS: Totally, 249 de novo physiologically significant coronary lesions from 231 patients who underwent FFR, CFR, and index of microcirculatory resistance (IMR) examinations before and after PCI were included...
January 16, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29334283/effects-of-an-exercise-program-on-the-physiological-biological-and-psychological-profiles-in-patients-with-mood-disorders-a-pilot-study
#5
Mario Leone, Daniel Lalande, Linda Thériault, Émilia Kalinova, Audrey Fortin
OBJECTIVE: The objective of this study is to assess the impact of an 8-week physical training program on physiological, biological and psychological profiles in individual with mood disorders. METHODS: Seven patients participated in the study. Patients were trained twice weekly (75 min/session) for 8 weeks. The training program aimed to improve muscular and cardiorespiratory reserves as well as functional capacity. Bioassays were also measured (lipid profile, blood glucose and cortisol)...
January 15, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29325636/left-atrial-appendage-closure-and-systemic-homeostasis-the-laa-homeostasis-study
#6
Dhanunjaya Lakkireddy, Mohit Turagam, Muhammad Rizwan Afzal, Johnson Rajasingh, Donita Atkins, Buddhadeb Dawn, Luigi Di Biase, Krzysztof Bartus, Saibal Kar, Andrea Natale, David J Holmes
BACKGROUND: The impact of left atrial appendage (LAA) exclusion, comparing an epicardial LAA or an endocardial LAA device, on systemic homeostasis remains unknown. OBJECTIVES: This study compared the effects of epicardial or endocardial LAA devices on the neurohormonal profiles of patients, emphasizing the roles of the renin-angiotensin-aldosterone system and the autonomic nervous system. METHODS: This is a prospective, single-center, observational study including 77 patients who underwent LAA closure by an epicardial (n = 38) or endocardial (n = 39) device...
January 16, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29324352/administration-of-exercise-conditioned-plasma-alters-muscle-catalase-kinetics-in-rat-an-argument-for-in-vivo-like-km-instead-of-in-vitro-like-vmax
#7
Aristidis S Veskoukis, Vassilis Paschalis, Antonios Kyparos, Michalis G Nikolaidis
Maximal velocity (Vmax) is a well established biomarker for the assessment of tissue redox status. There is scarce evidence, though, that it does not probably reflect sufficiently in vivo tissue redox profile. Instead, the Michaelis constant (Km) could more adequately image tissue oxidative stress and, thus, be a more physiologically relevant redox biomarker. Therefore, the aim of the present study was to side-by-side compare Vmax and Km of an antioxidant enzyme after implementing an in vivo set up that induces alterations in tissue redox status...
January 3, 2018: Redox Biology
https://www.readbyqxmd.com/read/29319912/transcriptomics-in-the-wild-hibernation-physiology-in-free-ranging-dwarf-lemurs
#8
Sheena L Faherty, José Luis Villanueva-Cañas, Marina B Blanco, Mar M Albà, Anne D Yoder
Hibernation is an adaptive strategy some mammals use to survive highly seasonal or unpredictable environments. We present the first investigation on the transcriptomics of hibernation in a natural population of primate hibernators: Crossley's dwarf lemurs (Cheirogaleus crossleyi). Using capture-mark-recapture techniques to track the same animals over a period of seven months in Madagascar, we used RNA-seq to compare gene expression profiles in white adipose tissue (WAT) during three distinct physiological states...
January 10, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29314506/efficacy-and-safety-of-sitagliptin-in-elderly-patients-with-type%C3%A2-2-diabetes-mellitus
#9
Motoko Tago, Jun-Ichi Oyama, Yoshiko Sakamoto, Aya Shiraki, Fumi Uchida, Atsuko Chihara, Hideo Ikeda, Shigetaka Kuroki, Shigeki Gondo, Taketo Iwamoto, Yasufumi Uchida, Koichi Node
AIM: The aim of the present study was to assess the efficacy and safety of sitagliptin in elderly patients with type 2 diabetes mellitus. METHODS: A total of 188 patients were enrolled who had type 2 diabetes mellitus with poor glycemic profiles (hemoglobin A1c [HbA1c] ≥6.2%). Patients were assigned to one of three age groups (<65, 65-74 and ≥75 years) and received 50-100 mg of sitagliptin daily for 12 months. Changes in HbA1c classified by age and body mass index (BMI) were assessed in addition to physiological parameters...
January 4, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29306587/perioperative-patient-outcomes-in-the-african-surgical-outcomes-study-a-7-day-prospective-observational-cohort-study
#10
Bruce M Biccard, Thandinkosi E Madiba, Hyla-Louise Kluyts, Dolly M Munlemvo, Farai D Madzimbamuto, Apollo Basenero, Christina S Gordon, Coulibaly Youssouf, Sylvia R Rakotoarison, Veekash Gobin, Ahmadou L Samateh, Chaibou M Sani, Akinyinka O Omigbodun, Simbo D Amanor-Boadu, Janat T Tumukunde, Tonya M Esterhuizen, Yannick Le Manach, Patrice Forget, Abdulaziz M Elkhogia, Ryad M Mehyaoui, Eugene Zoumeno, Gabriel Ndayisaba, Henry Ndasi, Andrew K N Ndonga, Zipporah W W Ngumi, Ushmah P Patel, Daniel Zemenfes Ashebir, Akwasi A K Antwi-Kusi, Bernard Mbwele, Hamza Doles Sama, Mahmoud Elfiky, Maher A Fawzy, Rupert M Pearse
BACKGROUND: There is a need to increase access to surgical treatments in African countries, but perioperative complications represent a major global health-care burden. There are few studies describing surgical outcomes in Africa. METHODS: We did a 7-day, international, prospective, observational cohort study of patients aged 18 years and older undergoing any inpatient surgery in 25 countries in Africa (the African Surgical Outcomes Study). We aimed to recruit as many hospitals as possible using a convenience sampling survey, and required data from at least ten hospitals per country (or half the surgical centres if there were fewer than ten hospitals) and data for at least 90% of eligible patients from each site...
January 3, 2018: Lancet
https://www.readbyqxmd.com/read/29304554/-i-in-vivo-i-epr-radical-concepts-for-translation-to-the-clinical-setting
#11
Valery V Khramtsov
EPR-based spectroscopic and imaging techniques allow for the study of free radicals - molecules with one or more unpaired electrons. Biological EPR applications include detection of endogenous biologically-relevant free radicals as well as use of specially designed exogenous radicals to probe local microenvironments. This forum issue focuses on recent advances in the field of <i>in vivo</i> EPR applications discussed at the International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems (EPR-2017)...
January 5, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29297391/personalized-physiological-medicine
#12
REVIEW
Can Ince
This paper introduces the concept of personalized physiological medicine that is specifically directed at the needs of the critically ill patient. This differs from the conventional view of personalized medicine, characterized by biomarkers and gene profiling, instead focusing on time-variant changes in the pathophysiology and regulation of various organ systems and their cellular and subcellular constituents. I propose that personalized physiological medicine is composed of four pillars relevant to the critically ill patient...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29289899/exploring-the-role-of-inositol-1-3-4-trisphosphate-5-6-kinase-2-gmitpk2-as-a-dehydration-and-salinity-stress-regulator-in-glycine-max-l-merr-through-heterologous-expression-in-e-coli
#13
Ashish Marathe, Veda Krishnan, T Vinutha, Anil Dahuja, Monica Jolly, Archana Sachdev
Phytic acid (PA) is implicative in a spectrum of biochemical and physiological processes involved in plant stress response. Inositol 1,3,4, Tris phosphate 5/6 kinase (ITPK), a polyphosphate kinase that converts Inositol 1,3,4 trisphosphate to Inositol 1,3,4,5/6 tetra phosphate, averting the inositol phosphate pool towards PA biosynthesis, is a key regulator that exists in four different isoforms in soybean. In the present study, in-silico analysis of the promoter region of ITPKs was done and among the four isoforms, promoter region of GmITPK2 showed the presence of two MYB binding elements for drought inducibility and one for ABA response...
December 19, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29289674/investigating-the-impact-of-drug-crystallinity-in-amorphous-tacrolimus-capsules-on-pharmacokinetics-and-bioequivalence-using-discriminatory-in-vitro-dissolution-testing-and-pbpk-modeling-and-simulation
#14
Hitesh S Purohit, Niraj S Trasi, Dajun D Sun, Edwin C Y Chow, Hong Wen, Xinyuan Zhang, Yi Gao, Lynne S Taylor
Delivering a drug in amorphous form in a formulated product is a strategy used to enhance the apparent solubility of a drug substance and its oral bioavailability. Drug crystallization in such products may occur during the manufacturing process or upon storage, reducing the solubility advantage of the amorphous drug. However, the impact of partial drug crystallization in the drug product on the resulting bioavailability and pharmacokinetics is unknown. In this study, dissolution testing of commercial tacrolimus capsules (which are formulated to contain amorphous drug), both fresh and those containing different amounts of crystalline drug, was conducted using both USP and non-compendial dissolution tests with different dissolution media and volumes...
December 28, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29289541/supervised-balance-training-and-wii-fit-based-exercises-lower-falls-risk-in-older-adults-with-type-2-diabetes
#15
Steven Morrison, Rachel Simmons, Sheri R Colberg, Henri K Parson, Aaron I Vinik
OBJECTIVES: This study examined the benefits of and differences between 12 weeks of thrice-weekly supervised balance training and an unsupervised at-home balance activity (using the Nintendo Wii Fit) for improving balance and reaction time and lowering falls risk in older individuals with type 2 diabetes mellitus (T2DM). DESIGN: Before-after trial. SETTING: University research laboratory, home environment. PARTICIPANTS: Sixty-five older adults with type 2 diabetes were recruited for this study...
December 27, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29284039/from-in-vivo-to-in-vitro-major-metabolic-alterations-take-place-in-hepatocytes-during-and-following-isolation
#16
Shamir Cassim, Valérie-Ann Raymond, Pascal Lapierre, Marc Bilodeau
The liver plays a key role in maintaining physiological homeostasis and hepatocytes are largely responsible for this. The use of isolated primary hepatocytes has become an essential tool for the study of nutrient physiology, xenobiotic metabolism and several liver pathologies. Since hepatocytes are removed from their normal environment, the isolation procedure and in vitro culture of primary hepatocytes is partially known to induce undesired metabolic changes. We aimed to perform a thorough metabolic profiling of primary cells before, during and after isolation using state-of-the-art techniques...
2017: PloS One
https://www.readbyqxmd.com/read/29283696/the-neuromuscular-determinants-of-unilateral-jump-performance-in-soccer-players-are-direction-specific
#17
Conall Murtagh, Christopher Nulty, Jos Vanrenterghem, Andy O'Boyle, Ryland Morgans, Barry Drust, Robert Erskine
PURPOSE: To investigate differences in neuromuscular factors between elite and non-elite players, and to establish which factors underpin direction-specific unilateral jump performance. METHODS: Elite (n=23; age, 18.1 ± 1.0 yrs; BMI, 23.1 ± 1.8 kg/m2) and non-elite (n=20; age, 22.3 ± 2.7 yrs; BMI, 23.8 ± 1.8 kg/m2) soccer players performed three unilateral countermovement jumps (CMJs) on a force platform in the vertical, horizontal-forward and medial directions...
December 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29283379/a-metabolomic-and-lipidomic-serum-signature-from-nonhuman-primates-administered-with-a-promising-radiation-countermeasure-gamma-tocotrienol
#18
Amrita K Cheema, Khyati Y Mehta, Oluseyi O Fatanmi, Stephen Y Wise, Charles P Hinzman, Josh Wolff, Vijay K Singh
The development of radiation countermeasures for acute radiation syndrome (ARS) has been underway for the past six decades, leading to the identification of multiple classes of radiation countermeasures. However, to date, only two growth factors (Neupogen and Neulasta) have been approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiation syndrome (H-ARS). No radioprotector for ARS has been approved by the FDA yet. Gamma-tocotrienol (GT3) has been demonstrated to have radioprotective efficacy in murine as well as nonhuman primate (NHP) models...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29251840/blood-brain-barrier-development-systems-modeling-and-predictive-toxicology
#19
REVIEW
Katerine S Saili, Todd J Zurlinden, Andrew J Schwab, Aymeric Silvin, Nancy C Baker, E Sidney Hunter, Florent Ginhoux, Thomas B Knudsen
The blood-brain barrier (BBB) serves as a gateway for passage of drugs, chemicals, nutrients, metabolites, and hormones between vascular and neural compartments in the brain. Here, we review BBB development with regard to the microphysiology of the neurovascular unit (NVU) and the impact of BBB disruption on brain development. Our focus is on modeling these complex systems. Extant in silico models are available as tools to predict the probability of drug/chemical passage across the BBB; in vitro platforms for high-throughput screening and high-content imaging provide novel data streams for profiling chemical-biological interactions; and engineered human cell-based microphysiological systems provide empirical models with which to investigate the dynamics of NVU function...
December 1, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29247937/eucalypt-plants-are-physiologically-and-metabolically-affected-by-infection-with-ceratocystis-fimbriata
#20
André Costa da Silva, Franklin Magnum de Oliveira Silva, Jocimar Caiafa Milagre, Rebeca Patricia Omena-Garcia, Mário Castro Abreu, Reginaldo Gonçalves Mafia, Adriano Nunes-Nesi, Acelino Couto Alfenas
Ceratocystis wilt, caused by Ceratocystis fimbriata, is currently one of the most important disease in eucalypt plantations. Plants infected by C. fimbriata have lower volumetric growth, lower pulp yields and reduced timber values. The physiological bases of infection induced by this pathogen in eucalypt plant are not known. Therefore, this study aims to assess the physiological and metabolic changes in eucalypt clones that are resistant and susceptible to C. fimbriata. Once, we evaluated in detail their leaf gas exchange, chlorophyll a fluorescence, water potential, metabolite profiling and growth-related parameters...
December 6, 2017: Plant Physiology and Biochemistry: PPB
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