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https://www.readbyqxmd.com/read/28527899/egfr-mutation-analysis-for-prospective-patient-selection-in-two-phase-ii-registration-studies-of-osimertinib
#1
Suzanne Jenkins, James Chih-Hsin Yang, Pasi A Jänne, Kenneth S Thress, Karen Yu, Rachel Hodge, Susie Weston, Simon Dearden, Sabina Patel, Mireille Cantarini, Frances A Shepherd
INTRODUCTION: Osimertinib is an oral, CNS active, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for the treatment of EGFR T790M-positive advanced non-small cell lung cancer (NSCLC). Here we evaluate EGFR mutation frequencies in two Phase II studies of osimertinib (AURA extension and AURA2). METHODS: Patients with EGFR mutation-positive advanced NSCLC provided tumor samples following progression on their latest line of therapy for mandatory central T790M testing for study selection criteria...
May 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28515265/clinical-marker-for-alzheimer-disease-pathology-in-logopenic-primary-progressive-aphasia
#2
Lucia A A Giannini, David J Irwin, Corey T McMillan, Sharon Ash, Katya Rascovsky, David A Wolk, Vivianna M Van Deerlin, Edward B Lee, John Q Trojanowski, Murray Grossman
OBJECTIVE: To determine whether logopenic features of phonologic loop dysfunction reflect Alzheimer disease (AD) neuropathology in primary progressive aphasia (PPA). METHODS: We performed a retrospective case-control study of 34 patients with PPA with available autopsy tissue. We compared baseline and longitudinal clinical features in patients with primary AD neuropathology to those with primary non-AD pathologies. We analyzed regional neuroanatomic disease burden in pathology-defined groups using postmortem neuropathologic data...
May 17, 2017: Neurology
https://www.readbyqxmd.com/read/28515213/rapid-identification-of-five-classes-of-carbapenem-resistance-genes-directly-from-rectal-swabs-using-the-xpert%C3%A2-carba-r-assay
#3
Nicholas M Moore, Rafael Cantón, Edoardo Carretto, Lance R Peterson, Robert L Sautter, Maria M Traczewski
Carbapenemase-producing organisms (CPO) have been identified by global health leaders as an urgent threat. Detection of patients with gastrointestinal carriage of CPO is necessary to interrupt their spread within healthcare facilities. In this multi-site study, we assessed the performance of the Xpert® Carba-R test, a rapid real-time PCR (qPCR) assay that detects five families of carbapenemase genes (blaIMP, blaKPC, blaNDM, blaOXA-48, and blaVIM) directly from rectal swab specimens. Using dual swabs, specimens from 755 patients were collected and tested prospectively...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28509362/developing-polyamine-based-peptide-amphiphiles-with-tunable-morphology-and-physicochemical-properties
#4
Mehdi Bin Samad, Yashpal Singh Chhonker, Jacob I Contreras, Alec McCarthy, Megan M McClanahan, Daryl J Murry, Martin Conda-Sheridan
The ability to tune supramolecular properties such as size, morphology, or metabolic stability is of paramount importance in the field of supramolecular chemistry. Peptide amphiphiles (PAs) are a family of functional self-assembling biomaterials that have garnered widespread attention due to their broad applicability in medicine. PAs are generally comprised of an amino acid sequence connected to lipid tail(s) allowing them to self-assemble into supramolecular structures with diverse morphologies. Herein, this study describes the synthesis of a new class of polyamine-based "hybrid" PAs (PPAs) as novel self-assembling systems...
May 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28503230/utility-of-preoperative-3-tesla-pelvic-phased-array-multiparametric-magnetic-resonance-imaging-in-prediction-of-extracapsular-extension-and-seminal-vesicle-invasion-of-prostate-cancer-and-its-impact-on-surgical-margin-status-experience-at-a-canadian-academic
#5
Taehyoung Lee, Jen Hoogenes, Ian Wright, Edward D Matsumoto, Bobby Shayegan
INTRODUCTION: To evaluate the utility of 3 Tesla (3T) pelvic phased-array (PPA) multiparametric magnetic resonance imaging (mpMRI) to predict extracapsular extension (ECE) and seminal vesicle invasion (SVI) and its subsequent effect on radical prostatectomy (RP) surgical margin status. METHODS: A retrospective evaluation was conducted of RP patients who underwent preoperative 3T PPA mpMRI (without endorectal coil) based on clinical probability of adverse pathological features...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28500875/upper-airway-changes-after-mandibular-setback-and-or-advancement-genioplasty-in-obese-patients
#6
Wen Du, Dongming He, Yiyao Wang, Hanghang Liu, Chuhang Liao, Wei Fei, En Luo
PURPOSE: Orthognathic surgeries, such as bilateral sagittal split ramus osteotomy (BSSO) and genioplasty, can influence the pharyngeal airway space (PAS) and this has been supported by previous studies. The purpose of this study was to assess changes of the PAS in patients with a high body mass index (BMI) likely to have narrow airways before and after setback BSSO with or without advancement genioplasty surgery by 3-dimensional computed tomography. MATERIALS AND METHODS: Thirty-five adults with a BMI of at least 24...
April 19, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28499144/patterns-of-response-to-scrambled-scenes-reveal-the-importance-of-visual-properties-in-the-organization-of-scene-selective-cortex
#7
David M Watson, Tom Hartley, Timothy J Andrews
Neuroimaging studies have found distinct patterns of neural response to different categories of scene in scene-selective regions of the human brain. However, it is not clear how information about scene category is represented in these regions. Images from different categories vary systematically in their visual properties as well as their semantic category. So, it is possible that patterns of neural response could reflect variation in visual properties. To address this question, we used fMRI to measure patterns of neural response to intact and scrambled scene categories...
April 21, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28498544/metabolic-engineering-of-cofactor-flavin-adenine-dinucleotide-fad-synthesis-and-regeneration-in-escherichia-coli-for-production-of-%C3%AE-keto-acids
#8
Ying Hou, Gazi Sakir Hossain, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Jian Chen, Long Liu
Cofactor flavin adenine dinucleotide (FAD) plays a vital role in many FAD-dependent enzymatic reactions; therefore, how to efficiently accelerate FAD synthesis and regeneration is an important topic in biocatalysis and metabolic engineering. In this study, a system involving the synthesis pathway and regeneration of FAD was engineered in Escherichia coli to improve α-keto acid production-from the corresponding L-amino acids-catalyzed by FAD-dependent L-amino acid deaminase (L-AAD). First, key genes, ribH, ribC, and ribF, were overexpressed and fine-tuned for FAD synthesis...
May 12, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28494517/exploration-of-peripapillary-vessel-density-in-highly-myopic-eyes-with-peripapillary-intrachoroidal-cavitation-and-its-relationship-with-ocular-parameters-using-optical-coherence-tomography-angiography
#9
Chen Qiuying, He Jiangnan, Hua Yihong, Fan Ying
IMPORTANCE: Identifying changes of peripapillary vessel density in highly myopic eyes with peripapillary intrachoroidal cavitation (PICC) by optical coherence tomography angiography (OCTA). BACKGROUND: To investigate peripapillary vessel density and its relationship with other ocular parameters in highly myopic eyes with PICC. DESIGN: This was a hospital-based, cross-sectional study. PARTICIPANTS: Thirty-five highly myopic eyes with PICC, 46 highly myopic eyes without PICC and 36 normal eyes were included in this study...
May 11, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28492150/selective-screening-for-organic-acidurias-and-amino-acidopathies-in-pakistani-children
#10
Noreen Abbas Sherazi, Aysha Habib Khan, Lena Jafri, Azeema Jamil, Nasir Ali Khan, Bushra Afroze
OBJECTIVE: To determine the frequency of organic acidurais (OA) and amino acidopathies (AA) in selected high-risk patients screened in two years. STUDY DESIGN: Retrospective Observational study. PLACE AND DURATION OF STUDY: The Aga Khan University Hospital (AKUH), Karachi, from January 2013 to December 2014. METHODOLOGY: Patients with OA and AA were included in the study and patients with IMDs other than OA and AA were excluded...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28490546/a-multicentre-evaluation-of-an-opioid-patient-provider-agreement
#11
Joseph V Pergolizzi, Frederick A Curro, Nanada Col, Mary Papa Ghods, Don Vena, Robert Taylor, Frederick Naftolin, Jo Ann LeQuang
The role of the patient-provider agreement (PPA) is to set forth respective roles and responsibilities for opioid therapy with the goal of improving outcomes, reducing risks, and improving patient education. The Food and Drug Administration (FDA) Safe Use Initiative Opioid PPA Working Group convened to develop a PPA and test it for acceptability as an educational and shared decision-making tool in opioid therapy. This multicentre study evaluated the utility of the PPA, how readily patients understood it, its ability to educate patients in an unbiased way about opioid treatment and the feasibility of incorporating a PPA in clinical practice...
May 10, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28475239/two-tourniquet-sequential-blocking-as-a-simple-intervention-for-hemorrhage-during-cesarean-delivery-for-placenta-previa-accreta
#12
Jin-Lai Meng, Wei-Yan Gong, Shan Wang, Xiao-Jing Ni, Chang-Ting Zuo, Yong-Zhong Gu
Placenta previa accreta (PPA) can result in severe obstetric hemorrhage, which usually necessitates hysterectomy. The median blood loss for placenta accreta has been reported to range from 2000 to 7800 mL [1]. It is a severe and life-threatening obstetric complication in most countries. The present article reports a conservative, simple method-the two-tourniquet sequential blocking technique-to control severe bleeding during cesarean delivery in the event of PPA. This article is protected by copyright. All rights reserved...
May 5, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28473597/diagnostic-performance-of-the-visual-reading-of-123-i-ioflupane-spect-images-when-assessed-with-or-without-quantification-in-patients-with-movement-disorders-or-dementia
#13
Jan Booij, Jacob Dubroff, Daniel Pryma, Jian Qin Yu, Rajan Agarwal, Paras Lakhani, Phillip H Kuo
Visual interpretation of (123)I-ioflupane single photon emission computed tomography (SPECT) images has high diagnostic accuracy to differentiate parkinsonian syndromes (PS) from essential tremor (ET) and probable dementia with Lewy bodies (DLB) from Alzheimer's disease. This study investigated the impact on accuracy and reader confidence offered by the addition of image quantification compared to visual interpretation alone. Methods: We collected 304 (123)I-ioflupane images from three trials, enrolling subjects with a clinical diagnosis of PS, non-PS (mainly ET), probable DLB and non-DLB (mainly Alzheimer's disease)...
May 4, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28458241/a-novel-pyridyl-triphenylamine-bodipy-aldoxime-naked-eye-visible-and-fluorometric-chemodosimeter-for-hypochlorite
#14
Xiu-Xiu Xu, Ying Qian
An aldoxime containing fluorescent probe based on vinylpydine-appended triphenylamine-BODIPY has been designed and used for hypochlorite detection. OX-PPA-BODIPY was developed by introducing an aldoxime group into the 2-position of BODIPY, which can be used for the detection of hypochlorite with a sharp color change from pink to green. The attachment of 4-vinylpyridine moiety to triphenylamine-BODIPY constructs a fluorogen with desirable conjugated system. The probe, which displays extremely weak fluorescence owing to the CN isomerization mechanism at 2-position of BODIPY, responds to HClO/ClO(-) through a dramatic enhancement of its fluorescence intensity...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28447816/does-combat-exposure-affect-well-being-in-later-life-the-va-normative-aging-study
#15
Hyunyup Lee, Carolyn M Aldwin, Soyoung Choun, Avron Spiro
OBJECTIVE: Combat exposure can have long-term negative effects in later life; although aspects of service may be appraised positively, the long-term positive effects of combat on well-being in later life is largely unknown. METHOD: The sample included 1,006 male veterans from the VA Normative Aging Study, surveyed by mail in 1986, 1990, and 1991 (Mage = 65.5 years, SD = 7.3). They reported on their combat exposure, desirable appraisals of military service, unit cohesion, dispositional optimism, self-rated health, and psychological well-being (PWB), as well as age, military rank, and education...
April 27, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28435097/defining-the-most-probable-location-of-the-parahippocampal-place-area-using-cortex-based-alignment-and-cross-validation
#16
REVIEW
Kevin S Weiner, Michael Barnett, Nathan Witthoft, Golijeh Golarai, Anthony Stigliani, Kendrick N Kay, Jesse Gomez, Vaidehi S Natu, Katrin Amunts, Karl Zilles, Kalanit Grill-Spector
The parahippocampal place area (PPA) is a widely studied high-level visual region in the human brain involved in place and scene processing. The goal of the present study was to identify the most probable location of place-selective voxels in medial ventral temporal cortex. To achieve this goal, we first used cortex-based alignment (CBA) to create a probabilistic place-selective region of interest (ROI) from one group of 12 participants. We then tested how well this ROI could predict place selectivity in each hemisphere within a new group of 12 participants...
April 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28434708/dual-phase-18-f-florbetapir-positron-emission-tomography-in-patients-with-primary-progressive-aphasia-alzheimer-s-disease-and-healthy-controls-a-preliminary-study
#17
Hung-Chou Kuo, Ing-Tsung Hsiao, Chia-Ju Hsieh, Chu-Yun Huang, Kuo-Lun Huang, Yau-Yau Wai, Wen-Li Chuang, Mei-Ping Kung, Yi-Chuan Chu, Tzu-Chen Yen, Kun-Ju Lin, Chin-Chang Huang
BACKGROUND: To determine whether dual-phase (18)F-florbetapir positron emission tomography imaging with perfusion-like and amyloid deposition information can distinguish among primary progressive aphasia (PPA), Alzheimer's disease (AD), and healthy controls (HCs). METHODS: Patients diagnosed with PPA, including four semantic dementia (SD) and two progressive nonfluent aphasia (PNFA), as well as one logopenic variant (LV) of PPA, were studied. All PPA patients, and age-/sex-matched patients with probable AD (n=8) and HCs (n=8) were subjected to dual-phase (18)F-florbetapir imaging...
April 20, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28428148/plasma-ctdna-analysis-for-detection-of-the-egfr-t790m-mutation-in-patients-with-advanced-non-small-cell-lung-cancer
#18
Suzanne Jenkins, James C-H Yang, Suresh S Ramalingam, Karen Yu, Sabina Patel, Susie Weston, Rachel Hodge, Mireille Cantarini, Pasi A Jänne, Tetsuya Mitsudomi, Glenwood D Goss
INTRODUCTION: Tumor biopsies for detecting epidermal growth factor receptor mutations (EGFRm) in advanced non-small cell lung cancer (NSCLC) are invasive, costly and not always feasible for patients with late-stage disease. The clinical utility of the cobas(®) EGFR Mutation Test v2 with plasma samples from patients with NSCLC at disease progression following previous EGFR-tyrosine kinase inhibitor (TKI) therapy was investigated to determine osimertinib treatment eligibility. METHODS: Matched tumor tissue and plasma samples from patients screened for AURA extension and AURA2 phase II studies were tested for EGFRm using tissue- and plasma-based cobas(®) EGFR Mutation Tests v2...
April 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28422564/evaluation-of-two-in-house-immunoenzymatic-tests-to-serodiagnose-subclinical-paratuberculisis-in-a-sheep-flock-in-mexicali-valley-mexico
#19
Elizama Ponce Barraza, Tomás Cárdenas Reyna, Carlos Angulo, José Carlomán Herrera Ramírez, Gilberto V López, Gerardo Enrique Medina-Basulto, Shigetoshi Eda, Sawako Hori-Oshima
Paratuberculosis (PTB) or Johne's disease is a common ruminant infectious disease caused by Mycobacterium avium subsp. paratuberculosis (MAP). In this study, two MAP antigens were compared for their diagnostic utility to detect subclinical PTB in a sheep flock in Mexicali, Mexico. Sheep (n = 31) without clinical signs but positive on a direct fecal-polymerase chain reaction were tested with two preabsorbed in-house enzyme linked immunosorbent assays (ELISAs) using: (1) an ethanol-extracted surface lipid antigen (EVELISA) and (2) a protoplasmic antigen (ELISA-PPA)...
April 19, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28414805/measurements-of-the-parapapillary-atrophy-zones-in-en-face-optical-coherence-tomography-images
#20
Atsuya Miki, Yasushi Ikuno, Robert N Weinreb, Junko Yokoyama, Tomoko Asai, Shinichi Usui, Kohji Nishida
OBJECTIVE: To measure the parapapillary atrophy (PPA) area in en face images obtained with swept-source optical coherence tomography (SS-OCT), and to evaluate its relationship to glaucoma, myopia, and age in non-highly myopic subjects. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: Fifty eyes of 30 subjects with open-angle glaucoma (G group) and forty-three eyes of 26 healthy control subjects (C group). Eyes with high myopia (spherical equivalent refractive error ≤ -8 diopters or axial length ≥ 26...
2017: PloS One
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