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https://www.readbyqxmd.com/read/29225440/smoking-urges-during-treatment-and-long-term-cessation-among-low-income-african-americans
#1
Monica Webb Hooper, Noella A Dietz, Joseph C Wilson
Objective: The urge to smoke is a predictor of smoking relapse. Little research has focused on the impact of acute urges during treatment among African Americans. This study examined the relationship between smoking urges and long-term abstinence among treatment seekers. Design: Longitudinal prospective investigation. Urges to smoke were assessed at the initial (session 1) and final (session 8) sessions among adult smokers (N=308) enrolled in a 4-week group intervention trial...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29213499/an-interdisciplinary-approach-aiding-the-diagnosis-of-primary-progressive-aphasia-a-case-report
#2
Nadia Shigaeff, Mayra Zanetti, Sibelle de Almeida Tierno, Ana Beatriz Galhardi Di Tommaso, Thais Cristina Marques, Fábio Gazelato de Mello Franco
Frontotemporal dementia (FTD) is one of the most common causes of early-onset dementia with primary progressive aphasia (PPA) being the second-most-frequent form of this degenerative disease. Despite the similarity with progressive dementia (especially in early stages of Alzheimer´s disease), three types of PPA can be differentiated: semantic, agrammatic and logopenic (subtype discussed in this study). To date, no medications have been shown to improve or stabilize cognitive deficits in patients with PPA. We report the case of a 62-year-old woman with difficulty naming objects and planning...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29179598/serum-paracetamol-protein-adducts-in-ambulatory-subjects-relationship-to-recent-reported-paracetamol-use
#3
Kennon Heard, Victoria E Anderson, Eric J Lavonas, Richard C Dart, Jody L Green
Context- Serum paracetamol-protein adducts (PPA) are a novel potential biomarker of paracetamol exposure. The relationship between serum PPA concentrations and reported paracetamol use in ambulatory adults has not been previously described. Materials and Methods- This was a cross-sectional study of ambulatory adults. A detailed medication history was obtained from all subjects and subjects were stratified by reported paracetamol use in the 2 weeks prior to enrollment. Serum PPA were measured in all subjects and correlated with reported dose, time of last ingestion and demographics...
November 28, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29178770/antibiotic-prophylaxis-for-preventing-dental-implant-failure-and-postoperative-infection-a-systematic-review-of-randomized-controlled-trials
#4
REVIEW
Zhuogeng Chen, Donghui Chen, Shangwei Zhang, Li Tang, Qiuying Li
PURPOSE: To investigate whether prophylactic antibiotics are beneficial on patients undergoing routine dental implant placement procedures and to investigate which administration regimen is the most effective. METHODS: The primary outcome was implant failure; the secondary outcome was postoperative infection. In the fixed-effects model, the Mantel-Haenszel method was used to calculate pooled relative risks (RRs) at 95% confidence intervals (CIs). To determine the outcomes, the quality of available evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE)...
April 2017: American Journal of Dentistry
https://www.readbyqxmd.com/read/29178408/spousal-recollections-of-early-signs-of-primary-progressive-aphasia
#5
Margaret Pozzebon, Jacinta Douglas, David Ames
BACKGROUND: Although primary progressive aphasia (PPA) is characterized by progressive loss of language and communication skills, knowledge about the earliest emerging signs announcing the onset of this condition is limited. AIMS: To explore spousal recollections regarding the earliest signs of PPA and to compare the nature of the earliest perceived symptoms across the three PPA variants. METHODS & PROCEDURES: In-depth interviews focusing on the earliest signs of illness onset were conducted with 13 spouses whose partners were diagnosed with PPA...
November 26, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29175373/non-invasive-t1%C3%AF-mapping-of-the-human-cartilage-response-to-loading-and-unloading
#6
Sven Nebelung, Björn Sondern, Holger Jahr, Markus Tingart, Matthias Knobe, Johannes Thüring, Christiane Kuhl, Daniel Truhn
OBJECTIVE: To define the physiological response to sequential loading and unloading in histologically intact human articular cartilage using serial T1ρ mapping, as T1ρ is considered to indicate the tissue's macromolecular content. METHOD: 18 macroscopically intact cartilage-bone samples were obtained from the central lateral femoral condyles of 18 patients undergoing total knee replacement. Serial T1ρ mapping was performed on a clinical 3.0-T MRI system using a modified prostate coil...
November 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29171726/factors-associated-with-deep-circulation-in-the-peripapillary-chorioretinal-atrophy-zone-in-normal-tension-glaucoma-with-myopic-disc
#7
Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
PURPOSE: To investigate factors associated with choroidal microcirculation in the peripapillary chorioretinal atrophy (PPA) zone in eyes with normal-tension glaucoma (NTG) and myopic disc. METHODS: In 100 eyes of 100 NTG patients with myopic disc and 20 eyes of 20 age-matched myopic controls, 4.5 × 4.5 mm scans were made of the optic nerve head with optical coherence tomography angiography (OCTA). Peripapillary chorioretinal atrophy (PPA) area and PPA superficial choroidal image intensity (PPA-CI) were calculated with image j software...
November 24, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29147888/a-study-of-parental-presence-absence-technique-for-child-dental-behaviour-management
#8
V Boka, K Arapostathis, G Charitoudis, J Veerkamp, C van Loveren, N Kotsanos
AIM: To examine the effectiveness of parental presence/absence (PPA) technique on the dental behaviour management of children. MATERIALS AND METHODS: This randomised control study recruited 61 child dental patients with uncooperative behaviour (Frankl 1 or 2) managed with AAPD-endorsed non-pharmacological techniques at a post-graduate university clinic. PPA was only used in the test group (31 children). Using a mini video-tape device, recording commenced at the onset of uncooperative behaviour and this was later rated, minute by minute, by a blinded experienced paediatric dentist...
November 16, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29145429/heritability-of-the-morphology-of-optic-nerve-head-and-surrounding-structures-the-healthy-twin-study
#9
Jong Chul Han, Hyeonyoung Ko, Seung Hoon Kim, Taekkwan Rhee, Seung Wan Nam, Sungsoon Hwang, Ga-In Lee, Joohon Sung, Yun-Mi Song, Changwon Kee
BACKGROUND: Optic nerve head (ONH) and surrounding structures such as β-zone peripapillary atrophy (PPA) are important structures in glaucomatous pathogenesis. Thus, for understanding genetic components in glaucoma pathogenesis, it is necessary to evaluate the heritability of ONH and surrounding structures. The present study investigated the genetic influences on ONH and surrounding structures such as β-zone PPA and retinal vessels. METHODS: A total of 1,205 adult twins and their family members (362 monozygotic (MZ) twin subjects (181 pairs), 64 dizygotic (DZ) twin subjects (32 pairs), and 779 singletons from 261 families), were part of the Korean Healthy Twin Study...
2017: PloS One
https://www.readbyqxmd.com/read/29142048/accurate-pcr-detection-of-influenza-a-b-and-rsv-using-the-cepheid-xpert-flu-rsv-xpress-assay-in-point-of-care-settings-comparison-to-prodesse-proflu
#10
Daniel M Cohen, Jennifer Kline, Larissa S May, Glenn Eric Harnett, Jane Gibson, Stephen Y Liang, Zubaid Rafique, Carina A Rodriguez, Kevin M McGann, Charlotte A Gaydos, Donna Mayne, David Phillips, Jason Cohen
The Xpert Flu+RSV Xpress Assay is a fast, automated in vitro diagnostic test for qualitative detection and differentiation of influenza A, B, and RSV performed on the Cepheid GeneXpert Xpress System. The objective of this study was to establish performance characteristics of the Xpert Flu+RSV Xpress Assay compared to the Prodesse ProFlu+ real-time RT-PCR assay (ProFlu+) for the detection of influenza A and B as well as RSV in a CLIA-waived (CW) setting. Overall, the assay, using fresh and frozen nasopharyngeal (NP) swabs, demonstrated high concordance with ProFlu+ in the combined CW and non-CW settings with Positive Percent Agreements (PPA) (100%, 100%, 97...
November 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29140277/enantioselective-biosynthesis-of-l-phenyllactic-acid-by-whole-cells-of-recombinant-escherichia-coli
#11
Yibo Zhu, Ying Wang, Jiayuzi Xu, Jiahao Chen, Limei Wang, Bin Qi
BACKGROUND: l-Phenyllactic acid (l-PLA)-a valuable building block in the pharmaceutical and chemical industry-has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid. However, both normally chemically synthesized and naturally occurring phenyllactic acid are racemic, and the product yields of reported l-PLA synthesis processes remain unsatisfactory. METHODS: We developed a novel recombinant Escherichia coli strain, co-expressing l-lactate dehydrogenase (l-LDH) from Lactobacillus plantarum subsp...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29137260/pathologic-subtype-defined-prognosis-is-dependent-on-both-tumor-stage-and-status-of-oncogenic-driver-mutations-in-lung-adenocarcinoma
#12
Yu Dong, Ying Li, Bo Jin, Jie Zhang, Jinchen Shao, Hong Peng, Shichun Tu, Baohui Han
Previous studies have shown that the prognosis of lung adenocarcinoma is associated with pathological characterization. In this study, we investigated whether pathology-based prognosis was further influenced by both tumor stage and oncogenic driver mutations. To this end, we recruited a cohort of 465 lung adenocarcinoma patients in China. These patients were classified into 6 pathology-defined subtypes i.e., lepidic-predominant adenocarcinoma (LPA), acinar-predominant adenocarcinoma (APA), papillary-predominant adenocarcinoma (PPA), micropapillary-predominant adenocarcinoma (MPA), solid-predominant adenocarcinoma (SPA), and invasive mucinous adenocarcinoma (IMA)...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29127274/effect-of-hydrogen-rich-saline-on-postoperative-intra-abdominal-adhesion-bands-formation-in-mice
#13
Zhong Liu, Sanfang Cheng, Changwei Gu, Honghong Pei, Xin Hong
BACKGROUND Postsurgical peritoneal adhesions (PPAs) are pathologic fibrous bands within the peritoneal cavity. The aim of this study was to investigate the protective effect of hydrogen-rich saline (HRS) on PPAs formation in mice. MATERIAL AND METHODS Adhesions were induced in mice using the cecum rubbing model. The mice were allocated into 4 groups: control sham group without cecum rubbing; PPA group with saline applied intraperitoneally (i.p.) daily after cecum rubbing; PPA+HRS (5) group with 5 ml/kg of HRS applied i...
November 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29117352/using-patient-pathway-analysis-to-design-patient-centered-referral-networks-for-diagnosis-and-treatment-of-tuberculosis-the-case-of-the-philippines
#14
Celine Garfin, Mariquita Mantala, Rajendra Yadav, Christy L Hanson, Mike Osberg, Aaron Hymoff, Julia Makayova
Background: Tuberculosis (TB) is the 8th leading cause of death in the Philippines. A recent prevalence survey found that there were nearly 70% more cases of tuberculosis than previously estimated. Given these new data, the National TB Program (NTP), operating through a decentralized health system, identified about 58% of the estimated new drug-sensitive (DS) TB patients in 2016. However, the NTP only identified and commenced treatment for around 17% of estimated new drug-resistant patients...
November 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29117351/finding-the-missing-patients-with-tuberculosis-lessons-learned-from-patient-pathway-analyses-in-5-countries
#15
Christy Hanson, Mike Osberg, Jessie Brown, George Durham, Daniel P Chin
Background: Despite significant progress in diagnosis and treatment of tuberculosis over the past 2 decades, millions of patients with tuberculosis go unreported every year. The patient-pathway analysis (PPA) is designed to assess the alignment between tuberculosis care-seeking patterns and the availability of tuberculosis services. The PPA can help programs understand where they might find the missing patients with tuberculosis. Methods: This analysis aggregates and compares the PPAs from case studies in Kenya, Ethiopia, Indonesia, the Philippines, and Pakistan...
November 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29117350/conducting-patient-pathway-analysis-to-inform-programming-of-tuberculosis-services-methods
#16
Christy L Hanson, Mike Osberg, Jessie Brown, George Durham, Daniel P Chin
Patient-centered care is a central pillar of the World Health Organization's End TB Strategy. Understanding where patients access health services is a first step to planning for the placement of services to meet patient needs and preferences. The patient-pathway analysis (PPA) methodology detailed in this article was developed to better understand the alignment between patient care seeking and tuberculosis service availability. A PPA describes the steps that people with tuberculosis take from the initial care visit to cure...
November 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29117349/using-patient-pathway-analysis-to-inform-a-differentiated-program-response-to-tuberculosis-the-case-of-kenya
#17
Enos Masini, Christy Hanson, Jeremiah Ogoro, Jessie Brown, Faith Ngari, Pia Mingkwan, Julia Makayova, Mike Osberg
Background: A recent tuberculosis prevalence survey in Kenya found that the country is home to nearly twice as many patients with tuberculosis as previously estimated. Kenya has prioritized identifying and treating the unnotified or missing cases of tuberculosis. This requires a better understanding of patient care seeking and system weaknesses. Methods: A patient-pathway analysis (PPA) was completed to assess the alignment between patient care seeking and the availability of tuberculosis diagnostic and treatment services at the national level and for all 47 counties at the subnational level in Kenya...
November 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29117348/delivering-patient-centered-care-in-a-fragile-state-using-patient-pathway-analysis-to-understand-tuberculosis-related-care-seeking-in-pakistan
#18
Razia Fatima, Mahboob Ul Haq, Aashifa Yaqoob, Nasir Mahmood, Khawaja Laeeq Ahmad, Mike Osberg, Julia Makayova, Aaron Hymoff, Christy Hanson
Background: Pakistan has the sixth largest population in the world and boasts the fifth greatest burden of tuberculosis. The Government of Pakistan has set the ambitious goal of zero deaths due to tuberculosis and universal access to tuberculosis care by 2020. Successfully reaching these goals is dependent on the country's capacity to diagnose and successfully treat an estimated 200000 unnotified or missing patients with tuberculosis. Methods: A patient-pathway analysis (PPA) was conducted at the national level, as well as for each of the 4 provinces, to assess the alignment between patient care seeking and the availability of tuberculosis diagnostic and treatment services...
November 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29117347/quality-tuberculosis-care-in-indonesia-using-patient-pathway-analysis-to-optimize-public-private-collaboration
#19
Asik Surya, Budiarti Setyaningsih, Helmi Suryani Nasution, Cicilia Gita Parwati, Yullita E Yuzwar, Mike Osberg, Christy L Hanson, Aaron Hymoff, Pia Mingkwan, Julia Makayova, Agnes Gebhard, Wiendra Waworuntu
Background: Tuberculosis (TB) is the fourth leading cause of death in Indonesia. In 2015, the World Health Organization estimated that nearly two-thirds of the TB patients in Indonesia had not been notified, and the status of their care remained unknown. As such, Indonesia is home to nearly 20% of the world's "missing" TB patients. Understanding where patients go for care may enable strategic planning of services to better reach them. Methods: A patient pathway analysis (PPA) was conducted to assess the alignment between patient care seeking and the availability of TB diagnostic and treatment services at the national and subnational level in Indonesia...
November 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29117008/topographic-relationship-between-optic-disc-torsion-and-%C3%A3-zone-peripapillary-atrophy-in-the-myopic-eyes-of-young-patients-with-glaucomatous-appearing-visual-field-defects
#20
Jiyun Lee, Jong Eun Lee, Junki Kwon, Joong Won Shin, Michael S Kook
PURPOSE: To assess the topographic correlation between optic disc torsion (ODT) and beta-zone peripapillary atrophy (β-PPA) in young patients with myopia and glaucomatous-appearing visual field defects (VFDs). PATIENTS AND METHODS: We consecutively recruited 110 eyes of 110 young patients with myopia and glaucomatous-appearing VFDs. Retinal nerve fiber layer (RNFL) and macular ganglion cell inner plexiform layer (mGCIPL) thicknesses were measured to compare between the groups with different ODT directions...
November 7, 2017: Journal of Glaucoma
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