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Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To identify ocular parameters corresponding to asymmetric visual field (VF) loss in normal tension glaucoma (NTG) through intereye comparisons. PATIENTS AND METHODS: Medical records of NTG patients with asymmetric and symmetric VF losses were retrospectively reviewed. The criterion for asymmetry in VF was 6 dB difference of mean deviation. Refractive error, intraocular pressure (IOP), central corneal thickness, ovality index, and peripapillary atrophy (PPA)/disc area ratio were obtained from each patient...
2017: PloS One
Caleb D Bazyler, Satoshi Mizuguchi, Ashley A Kavanaugh, John J McMahon, Paul Comfort, Michael H Stone
PURPOSE: To determine if jumping performance changes during a peaking phase differed between returners and new players in a female collegiate volleyball team and to determine which variables best explained the variation in performance changes. METHODS: Fourteen volleyball players were divided into two groups: returners (n=7) and new players (n=7) who completed a 5-week peaking phase prior to conference championships. Players were tested at baseline prior to the pre-season on measures of vastus lateralis cross-sectional area using ultrasonography, estimated back squat one repetition maximum (1-RM), and countermovement jump height (JH) and relative peak power (PPa) on a force platform...
October 16, 2017: International Journal of Sports Physiology and Performance
Peiman Nazerian, Christian Mueller, Alexandre de Matos Soeiro, Bernd A Leidel, Sibilla Anna Teresa Salvadeo, Francesca Giachino, Simone Vanni, Karin Grimm, Múcio T Oliveira, Emanuele E Pivetta, Enrico Lupia, Stefano Grifoni, Fulvio Morello
Background -Acute aortic syndromes (AAS) are rare and severe cardiovascular emergencies with unspecific symptoms. For AAS, both misdiagnosis and over-testing are key concerns, and standardized diagnostic strategies may help physicians to balance these risks. D-dimer (DD) is highly sensitive for AAS, but is inadequate as a standalone test. Integration of pre-test probability assessment (PPA) with D-dimer (DD) testing is feasible, but the safety and efficiency of such diagnostic strategy are currently unknown...
October 13, 2017: Circulation
Maura Cosseddu, Alberto Benussi, Stefano Gazzina, Rosanna Turrone, Silvana Archetti, Elisa Bonomi, Giorgio Biasiotto, Isabella Zanella, Raffaele Ferrari, Maria S Cotelli, Antonella Alberici, Alessandro Padovani, Barbara Borroni
OBJECTIVE: Frontotemporal dementia (FTD) is a common cause of young onset dementia. Very few reports on disease duration are currently available and predictors of survival are still undefined. The aim of the present study was to assess the natural history of FTD and to define predictors of survival. METHODS: Four hundred amd eleven FTD patients, including 294 with behavioural variant FTD, 77 with agrammatic variant primary progressive aphasia (PPA) and 40 with semantic variant PPA, were consecutively enrolled and demographic and clinical variables carefully recorded...
October 8, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Fanny M Elahi, Gabe Marx, Yann Cobigo, Adam M Staffaroni, John Kornak, Duygu Tosun, Adam L Boxer, Joel H Kramer, Bruce L Miller, Howard J Rosen
BACKGROUND: Degradation of white matter microstructure has been demonstrated in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). In preparation for clinical trials, ongoing studies are investigating the utility of longitudinal brain imaging for quantification of disease progression. To date only one study has examined sample size calculations based on longitudinal changes in white matter integrity in FTLD. OBJECTIVE: To quantify longitudinal changes in white matter microstructural integrity in the three canonical subtypes of frontotemporal dementia (FTD) and AD using diffusion tensor imaging (DTI)...
2017: NeuroImage: Clinical
H P Gajera, Shila N Gevariya, Darshna G Hirpara, S V Patel, B A Golakiya
ABSTRACT: Fruit phenolics are important dietary antioxidant and antidiabetic constituents. The fruit parts (pulp, seed, seed coat, kernel) of underutilized indigenous six black jamun landraces (Syzygium cumini L.), found in Gir forest region of India and differed in their fruit size, shape and weight, are evaluated and correlated with antidiabetic, DPPH radical scavenging and phenolic constituents. The α-amylase inhibitors propose an efficient antidiabetic strategy and the levels of postprandial hyperglycemia were lowered by restraining starch breakdown...
September 2017: Journal of Food Science and Technology
You Lu, Carol Ishimaru, Jane Glazebrook, Deborah A Samac
Clavibacter michiganensis is the most economically important gram-positive bacterial plant pathogen with subspecies that cause serious diseases of maize, wheat, tomato, potato, and alfalfa. Much less is known about pathogenesis involving gram-positive plant pathogens than is known for gram-negative bacteria. Comparative genome analyses of C. michiganensis subspecies affecting tomato, potato, and maize have provided insights on pathogenicity. In this study, we identified strains of C. michiganensis subsp. insidiosus with contrasting pathogenicity on three accessions of the model legume Medicago truncatula...
September 27, 2017: Phytopathology
Xilin Zhang, Nicole Mlynaryk, Shruti Japee, Leslie G Ungerleider
Classic theories of object-based attention assume a single object of selection but real-world tasks, such as driving a car, often require attending to multiple objects simultaneously. However, whether object-based attention can operate on more than one object at a time remains unexplored. Here, we used functional magnetic resonance imaging (fMRI) to address this question as human participants performed object-based attention tasks that required simultaneous attention to two objects differing in either their features or locations...
September 23, 2017: NeuroImage
Luyan Mu, Wanzhen Xu, Qingla Li, Haitao Ge, Hongbo Bao, Songsong Xia, Jingjing Ji, Jie Jiang, Yuwen Song, Qiang Gao
IDH1 R132H mutation is an important marker of survival in patients with gliomas. Although there are many changes of genes in tumour malignant progression, IDH1 R132H mutation status in glioma progression remained unclear. Here, an in-depth characterization of IDH1 R132H mutations were assessed by immunohistochemistry in 55 paired primary-recurrent astrocytomas tissues, including 5 paired primary pilocytic astrocytoma (pPA, WHO grade I), 35 paired primary low grade astrocytoma (pLGA, WHO grade II and III) and 15 paired primary high grade astrocytoma (pHGA/ Glioblastoma, WHO grade IV)...
2017: Journal of Cancer
Fei Lin, Zhaohe Liu, Tiantian Wang, Dongmei Cui
Rare-earth metal complexes (Flu-CH2 -Py)Ln(CH2 SiMe3 )2 (THF)n (Ln=Sc(1), Lu(2), Tm(3), Y(4) and Gd(5)), upon the activation of [Ph3 C][B(C6 F5 )4 ] and Al(i) Bu3 , were employed to catalyze the polymerization of allene derivatives under mild conditions. The Gd, Y, Tm, Lu metal based precursors exhibited distinguished 2,3-selectivity (>99.9 %) for phenylallene (PA) polymerization, whereas the smallest Sc metal based precursor showed a moderate 2,3-selectivity. The activity increased with the central metal size following the trend of Gd(5)>Tm(4)>Y(3)>Lu(2)>Sc(1)...
September 19, 2017: Angewandte Chemie
H C Bergeron, P S Glas, K R Schumann
African swine fever (ASF) is a highly contagious haemorrhagic disease of pigs that has the potential to cause mortality nearing 100% in naïve animals. While an outbreak of ASF in the United States' pig population (domestic and feral) has never been reported, an introduction of the disease has the potential to cause devastation to the pork industry and food security. During the recovery phase of an outbreak, an antibody detection diagnostic assay would be required to prove freedom of disease within the previously infected zone and eventually nationwide...
September 18, 2017: Transboundary and Emerging Diseases
Misako Okumura, Martin Wilecki, Ralf J Sommer
Feeding behaviors in a wide range of animals are regulated by the neurotransmitter serotonin, although the exact neural circuits and associated mechanism are often unknown. The nematode Pristionchus pacificus can kill other nematodes by opening prey cuticles with movable teeth. Previous studies showed that exogenous serotonin treatment induces a predatory-like tooth movement and slower pharyngeal pumping in the absence of prey, however, physiological functions of serotonin during predation and other behaviors in P...
September 13, 2017: G3: Genes—Genomes—Genetics
Yolandi Breet, Hugo W Huisman, Ruan Kruger, Johannes M van Rooyen, Lebo F Gafane-Matemane, Lisa J Ware, Aletta E Schutte
BACKGROUND: Pulse pressure amplification (PPA), i.e. the amplification from central arteries to the periphery, is inversely related to arterial stiffness, organ damage and mortality. It is known that arterial stiffness is higher in black than white populations, but it is unclear if this is due to early vascular aging. We therefore investigated whether PPA declines earlier in young normotensive black South Africans, when compared to their white counterparts. METHODS: We included 875 black and white men and women from the African-PREDICT study (55% black, 41% men), aged 20-30years, with no prior diagnosis of chronic disease, screened for normotensive clinic blood pressure (BP)...
September 5, 2017: International Journal of Cardiology
Sebastian Barreto Ortiz, Daijiro Hori, Yohei Nomura, Xin Yun, Haiyang Jiang, Hwanmee Yong, James Chen, Sam Paek, Deepesh Pandey, Gautam Sikka, Anil Bhatta, Andrew Gillard, Jochen Steppan, Jae Hyung Kim, Hideo Adachi, Viachaslau Barodka, Lewis Romer, Steven S An, Larissa A Shimoda, Lakshmi Santhanam, Dan E Berkowitz
We recently demonstrated that blue light induces vasorelaxation in the systemic mouse circulation, a phenomenon mediated by the non-visual G protein-coupled receptor (GPCR) melanopsin (opsin 4; Opn4). Here we tested the hypothesis that non-visual opsins mediate photorelaxation in the pulmonary circulation. We discovered Opsin 3 (Opn3), Opn4, and G-protein coupled receptor kinase 2 (GRK2) in rat pulmonary arteries (PAs) and in pulmonary arterial smooth muscle cells (PASMCs), where the opsins interact directly with GRK2 as demonstrated with a proximity ligation assay...
September 7, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
Lixia Chen, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai
Phenyllactic acid (PLA) is a novel antimicrobial compound. A novel NADH-dependent d-lactate dehydrogenase (d-LDH), named as LF-d-LDH0653, with high phenylpyruvate (PPA) reducing activity was isolated from Lactobacillus fermentum JN248. Its optimum pH and temperature were 8.0 and 50 °C, respectively. The Michaelis-Menten constant (Km ), turnover number (kcat ), and catalytic efficiency (kcat /Km ) for NADH were 1.20 mmol/L, 67.39 s(-1) , and 56.16 (mmol/L)(-1) s(-1) , respectively. The (Km ), (kcat ), and (kcat /Km ) for phenylpyruvate were 1...
October 2017: Journal of Food Science
Namita Multani, Sebastiano Galantucci, Stephen M Wilson, Tal Shany-Ur, Pardis Poorzand, Matthew E Growdon, Jung Yun Jang, Joel H Kramer, Bruce L Miller, Katherine P Rankin, Maria Luisa Gorno-Tempini, Maria Carmela Tartaglia
Non-cognitive features including personality changes are increasingly recognized in the three PPA variants (semantic-svPPA, non fluent-nfvPPA, and logopenic-lvPPA). However, differences in emotion processing among the PPA variants and its association with white matter tracts are unknown. We compared emotion detection across the three PPA variants and healthy controls (HC), and related them to white matter tract integrity and cortical degeneration. Personality traits in the PPA group were also examined in relation to white matter tracts...
2017: NeuroImage: Clinical
Patricia J Simner, Margret Oethinger, Kathleen A Stellrecht, Dylan R Pillai, Ram Yogev, Helene Leblond, Joel Mortensen
The purpose of this study was to perform a multisite evaluation to establish the performance characteristics of the BD MAX™ Extended Enteric Bacterial Panel (xEBP) assay directly from unpreserved or Cary-Blair preserved stool specimens for the detection of Yersinia enterocolitica, Enterotoxigenic Escherichia coli (ETEC), Vibrio and Plesiomonas shigelloides The study included prospective, retrospective and prepared contrived specimens from 6 clinical sites. BD MAX™ xEBP results were compared to the reference method which included standard culture techniques coupled with alternate PCR and sequencing, except ETEC for which the reference method were two alternate PCRs and sequencing...
September 6, 2017: Journal of Clinical Microbiology
Daniel A Ortiz, Michael J Loeffelholz
A syphilis diagnosis is often aided by the detection of treponemal and non-treponemal antibodies. Automated treponemal antibody detection systems enable high-volume clinical laboratories to perform syphilis screening at a faster pace with lower labor costs. The Lumipulse G TP-N chemiluminescent immunoassay is an automated system that qualitatively detects IgG and IgM antibodies against Treponema pallidum antigens in human serum and plasma. To assess performance characteristics and workflow efficiency, the Lumipulse G TP-N assay was compared to the Bioplex 2200 Syphilis IgG multiplex flow immunoassay...
September 6, 2017: Journal of Clinical Microbiology
Dongdong Yuan, Jean Christophe Jacquier, E Dolores O'Riordan
Bovine serum albumin (BSA), whey protein isolate (WPI), insulin and a casein hydrolysate were entrapped in chitosan-polyphosphoric acid (PPA) beads. The in vitro release of protein from the beads in simulated gastric fluid (SGF, pH 3) and simulated intestinal fluid (SIF, pH 7) was evaluated. High entrapment efficiencies were achieved for intact proteins (>95% in all cases) but entrapment was lower for the casein hydrolysate (circa 50%), possibly indicating a physical or steric entrapment of the proteins in these chitosan-PPA beads...
January 15, 2018: Food Chemistry
Stephen M Wilson, Charlotte Dehollain, Sophie Ferrieux, Laura E H Christensen, Marc Teichmann
The most salient clinical symptom of semantic variant primary progressive aphasia (PPA) is a profound and pervasive anomia. These patients' naming impairments have been shown to reflect in large part a domain-general deterioration of conceptual knowledge that impacts both linguistic and non-linguistic processing. However, it is possible that post-semantic stages of lexical access may also contribute to naming deficits. To clarify the stages at which lexical access breaks down in semantic variant PPA, eleven French-speaking patients were asked to name objects, and were then queried for semantic, lexical-syntactic, and word form information pertaining to the items they could not name...
September 1, 2017: Neuropsychologia
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