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https://www.readbyqxmd.com/read/28335432/marine-lectins-dlfbl-and-hddsbl-fused-with-soluble-coxsackie-adenovirus-receptor-facilitate-adenovirus-infection-in-cancer-cells-but-have-different-effects-on-cell-survival
#1
Bingbing Wu, Shengsheng Mei, Lianzhen Cui, Zhenzhen Zhao, Jianhong Chen, Tao Wu, Gongchu Li
Cancer development and progression are usually associated with glycosylation change, providing prognostic and diagnostic biomarkers, as well as therapeutic targets, for various cancers. In this work, Dicentrarchus labrax fucose binding lectin (DlFBL) and Haliotis discus discus sialic acid binding lectin (HddSBL) were genetically fused with soluble coxsackie-adenovirus receptor (sCAR), and produced through a bacterial expression system. Results showed that recombinant sCAR-DlFBL not only facilitated adenovirus Ad-EGFP infection in K562/ADR and U87MG cells, but also enhanced the cytotoxicity of adenovirus harboring gene encoding Pinellia pedatisecta agglutinin (PPA) or DlFBL (Ad-PPA or Ad-DlFBL) on U87MG cells through inducing apoptosis...
March 14, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28335344/a-targeted-nanoprobe-based-on-carbon-nanotubes-natural-biopolymer-chitosan-composites
#2
Baoyan Wu, Na Zhao
A novel targeting theranostic nanoprobe based on single-walled carbon nanotubes (SWCNTs)-natural biopolymer chitosan composites was developed for cancer cell targeting imaging and fluorescence imaging-guided photodynamic therapy. First, chitosan was respectively conjugated with a tumor-homing molecule folic acid, or a photosensitizing drug pyropheophorbide a using a water-soluble carbodiimide coupling chemistry. Chitosan was fluorescently labeled by fluorescein isothiocyanate via the covalently linkage of the isothiocyanate group with the amino group...
November 17, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28333289/the-role-of-daf-21-hsp90-in-mouth-form-plasticity-in-pristionchus-pacificus
#3
Bogdan Sieriebriennikov, Gabriel V Markov, Hanh Witte, Ralf J Sommer
Phenotypic plasticity is increasingly recognized to facilitate adaptive change in plants and animals, including insects, nematodes and vertebrates. Plasticity can occur as continuous or discrete (polyphenisms) variation. In social insects, e.g. in ants, some species have workers of distinct size classes while in other closely related species variation in size may be continuous. Despite the abundance of examples in nature, how discrete morphs are specified remains currently unknown. In theory, polyphenisms might require robustness, whereby the distribution of morphologies would be limited by the same mechanisms that execute buffering from stochastic perturbations, a function attributed to heat-shock proteins of the Hsp90 family...
March 13, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28331820/correlation-in-histological-subtypes-with-high-resolution-computed-tomography-signatures-of-early-stage-lung-adenocarcinoma
#4
Yingying Miao, Jianya Zhang, Jiawei Zou, Qingqing Zhu, Tangfeng Lv, Yong Song
BACKGROUND: Uncertainty remains on the association between image characteristics of the nodules in computed tomography (CT) scans and lung adenocarcinoma histopathologic subtypes. We aimed to estimate the correlation between preoperative high resolution computed tomography (HRCT) scan and postoperative histopathology of stage IA lung adenocarcinoma in East Asian Chinese population. METHODS: We retrospectively reviewed the clinical records and HRCT images of 190 patients (106 female and 84 male) with resected, preoperatively untreated stage IA adenocarcinomas...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28304307/logopenic-aphasia-due-to-a-strategic-stroke-new-evidence-from-a-single-case
#5
Javier Riancho, Ana Pozueta, Miguel Santos, Carmen Lage, José M Carril, Ignacio Banzo, Isabel Martínez-Rodriguez, Marilu Gorno-Tempini, Pascual Sánchez-Juan
Among primary progressive aphasias (PPAs), logopenic variant PPA (lv-PPA) is usually related to Alzheimer's disease. Although it has been widely clinically and pathologically evaluated, the topography in LPA is still controversial. We report a patient presenting with a logopenic syndrome due to a strategic lesion located in the superior and middle temporal gyrus and compare our findings with those of a PiB-PET positive lv-PPA patient matched by age, gender, and education. We consider that our study provides new anatomical clues to better understand the cognitive mechanisms underlying the logopenic syndrome...
March 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28301100/comparison-of-mr-flow-quantification-in-peripheral-and-main-pulmonary-arteries-in-patients-after-right-ventricular-outflow-tract-surgery-a-retrospective-study
#6
Tobias Rutz, Christian Meierhofer, Susanne Naumann, Stefan Martinoff, Peter Ewert, Heiko C Stern, Sohrab Fratz
PURPOSE: To compare the quantification of pulmonary stroke volume (SV) by phase contrast magnetic resonance (PC-MR) in the main pulmonary artery (MPA) to the sum of SVs in both peripheral pulmonary arteries (PPA) in different right ventricular (RV) outflow pathologies. MATERIALS AND METHODS: Pulmonary SV was determined by PC-MR in the MPA and the PPA in healthy individuals (H, n = 54), patients after correction for tetralogy of Fallot with significant pulmonary regurgitation and without pulmonary or RV outflow tract stenosis (PR, n = 50), and in patients with RV outflow tract or pulmonary valve stenosis (PS, n = 50)...
March 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28297027/underlying-microstructure-of-parapapillary-deep-layer-capillary-dropout-identified-by-optical-coherence-tomography-angiography
#7
Eun Ji Lee, Tae-Woo Kim, Seung Hyen Lee, Jung-Ah Kim
Purpose: To characterize the microstructure underlying the parapapillary deep-layer microvasculature dropout (MvD) identified by optical coherence tomography (OCT) angiography (OCTA) in eyes with primary open-angle glaucoma (POAG). Methods: Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en face images obtained using swept-source OCTA. The peripapillary microstructure was characterized in 188 POAG patients with MvD in the parapapillary deep layer...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28289749/motor-speech-phenotypes-of-frontotemporal-dementia-primary-progressive-aphasia-and-progressive-apraxia-of-speech
#8
Matthew L Poole, Amy Brodtmann, David Darby, Adam P Vogel
Purpose: Our purpose was to create a comprehensive review of speech impairment in frontotemporal dementia (FTD), primary progressive aphasia (PPA), and progressive apraxia of speech in order to identify the most effective measures for diagnosis and monitoring, and to elucidate associations between speech and neuroimaging. Method: Speech and neuroimaging data described in studies of FTD and PPA were systematically reviewed. A meta-analysis was conducted for speech measures that were used consistently in multiple studies...
March 13, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28288010/functional-connectivity-is-reduced-in-early-stage-primary-progressive-aphasia-when-atrophy-is-not-prominent
#9
Borna Bonakdarpour, Emily J Rogalski, Allan Wang, Jaiashre Sridhar, M M Mesulam, Robert S Hurley
Primary progressive aphasia (PPA) is a clinical syndrome of language decline caused by neurodegenerative pathology. Although language impairments in PPA are typically localized via the morphometric assessment of atrophy, functional changes may accompany or even precede detectable structural alterations, in which case resting state functional connectivity (RSFC) could provide an alternative approach. The goal of this study was to determine whether language network RSFC is reduced in early-stage PPA when atrophy is not prominent...
March 10, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28260836/organic-to-aqueous-phase-transfer-of-cadmium-chalcogenide-quantum-dots-using-a-sulfur-free-ligand-for-enhanced-photoluminescence-and-oxidative-stability
#10
Raul Calzada, Christopher M Thompson, Dana E Westmoreland, Kedy Edme, Emily A Weiss
This paper describes a procedure for transferring colloidal CdS and CdSe quantum dots (QDs) from organic solvents to water by exchanging their native hydrophobic ligands for phosphonopropionic acid (PPA) ligands, which bind to the QD surface through the phosphonate group. This method, which uses dimethylformamide as an intermediate transfer solvent, was developed in order to produce high-quality water soluble QDs with neither a sulfur-containing ligand nor a polymer encapsulation layer, both of which have disadvantages in applications of QDs to photocatalysis and biological imaging...
September 27, 2016: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/28260599/peritonsillar-abscess-clinical-aspects-of-microbiology-risk-factors-and-the-association-with-parapharyngeal-abscess
#11
REVIEW
Tejs Ehlers Klug
PTA is a collection of pus located between the tonsillar capsule and the pharyngeal constrictor muscle. It is considered a complication of acute tonsillitis and is the most prevalent deep neck infection (approximately 2000 cases annually in Denmark) and cause of acute admission to Danish ENT departments. Teenagers and young adults are most commonly affected and males may predominate over females. However, no studies of age- and gender-stratified incidence rates have previously been published. Furthermore, smoking may be associated with increased risk of peritonsillar abscess (PTA) development, although the magnitude of the association has not been estimated...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28229040/predicting-primary-progressive-aphasias-with-support-vector-machine-approaches-in-structural-mri-data
#12
Sandrine Bisenius, Karsten Mueller, Janine Diehl-Schmid, Klaus Fassbender, Timo Grimmer, Frank Jessen, Jan Kassubek, Johannes Kornhuber, Bernhard Landwehrmeyer, Albert Ludolph, Anja Schneider, Sarah Anderl-Straub, Katharina Stuke, Adrian Danek, Markus Otto, Matthias L Schroeter
Primary progressive aphasia (PPA) encompasses the three subtypes nonfluent/agrammatic variant PPA, semantic variant PPA, and the logopenic variant PPA, which are characterized by distinct patterns of language difficulties and regional brain atrophy. To validate the potential of structural magnetic resonance imaging data for early individual diagnosis, we used support vector machine classification on grey matter density maps obtained by voxel-based morphometry analysis to discriminate PPA subtypes (44 patients: 16 nonfluent/agrammatic variant PPA, 17 semantic variant PPA, 11 logopenic variant PPA) from 20 healthy controls (matched for sample size, age, and gender) in the cohort of the multi-center study of the German consortium for frontotemporal lobar degeneration...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28225576/3d-multiecho-dixon-for-the-evaluation-of-hepatic-iron-and-fat-in-a-clinical-setting
#13
Benjamin Henninger, Heinz Zoller, Stephan Kannengiesser, Xiaodong Zhong, Werner Jaschke, Christian Kremser
PURPOSE: To prospectively evaluate a new 3D-multiecho-Dixon (3D-ME-Dixon) sequence for the quantification of hepatic iron and fat in a clinical setting. MATERIALS AND METHODS: In all, 120 patients underwent 1.5T magnetic resonance imaging of the liver between December 2013 and June 2015 including the following three sequences: 3D-ME-Dixon with inline calculation of R2* and proton-density fat-fraction (PDFF) maps, single-voxel-spectroscopy (SVS), 2D multigradient-echo sequence (2D-ME-GRE)...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28224419/a-retrospective-study-of-branch-atheromatous-disease-analyses-of-risk-factors-and-prognosis
#14
Yang Liu, Yuan-Teng Fan, Yu-Min Liu, Tao Wang, Hong-Liang Feng, Guang-Zhi Liu, Bin Mei
The theory of branch atheromatous disease (BAD) has been commonly underused in clinical practice and research since it was proposed in 1989. In this study, we sought to explore clinical characteristics of its substypes and biomarkers for prognosis of BAD. A total of 176 consecutive patients with BAD were classified into two groups: paramedianpontine artery group (PPA group, n=70) and lenticulostriate artery group (LSA group, n=106). Bivariate analyses were used to explore the relationship between white matter hyperintensities (WMHs), National Institutes of Health Stroke Scale (NIHSS) scores and prognosis evaluated by the modified Rank Scale (mRS) at 6th month after stroke...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28220965/defect-edge-selective-functionalization-of-carbon-materials-by-direct-friedel-crafts-acylation-reaction
#15
REVIEW
Jeong-Min Seo, Loon-Seng Tan, Jong-Beom Baek
Popularly utilized oxidation media, via nitric acid/sulfuric acid mixtures, are too corrosive and oxidizing to preserve structural integrity of highly ordered graphitic materials (carbon nanotubes (CNTs) and graphene). Here, for the most commonly used oxidation method, the important advantages of defect/edge-selective functionalization of carbon materials (CNTs/graphene/graphite) in a polyphosphoric acid (PPA)/phosphorous pentoxide (P2 O5 ) medium are elucidated. The optimized PPA/P2 O5 medium is a mild acid that is not only less corrosive than popularly utilized oxidation media, but also has a strong capability to drive Friedel-Crafts acylation by covalently modifying carbon materials...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28187331/temporal-acoustic-measures-distinguish-primary-progressive-apraxia-of-speech-from-primary-progressive-aphasia
#16
Joseph R Duffy, Holly Hanley, Rene Utianski, Heather Clark, Edythe Strand, Keith A Josephs, Jennifer L Whitwell
The purpose of this study was to determine if acoustic measures of duration and syllable rate during word and sentence repetition, and a measure of within-word lexical stress, distinguish speakers with primary progressive apraxia of speech (PPAOS) from nonapraxic speakers with the agrammatic or logopenic variants of primary progressive aphasia (PPA), and control speakers. Results revealed that the PPAOS group had longer durations and reduced rate of syllable production for most words and sentences, and the measure of lexical stress...
May 2017: Brain and Language
https://www.readbyqxmd.com/read/28185309/initial-evaluation-of-99m-tc-tricarbonyl-cyclopentadienyl-fatty-acids-derivatives-as-spect-tracers-for-myocardium
#17
Jianping Liu, Huan Wang, Shuxia Wang, Qianqian Xue, Dawei Wang, Wang Hang, Huabei Zhang
Fatty acids are myocardial metabolic agent for detecting myocardial ischemia and infraction. However, no (99m) Tc-labeled fatty acids had potential use in clinical practice. In this study, (99m) Tc-CpTT-10-oxo-para-PPA (1d), (99m) Tc-CpTT-11-oxo-para-PPA (2d), (99m) Tc-CpTT-12-oxo-para-PPA (3d), (99m) Tc-CpTT-11-oxo-ortho-PPA (4d) and (99m) Tc-CpTT-11-oxo-meta-PPA (5d) were synthesized by a double ligand transfer reaction, their biological behaviors were investigated. Compound 2d achieved good heart/blood ratio (3...
February 9, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28185066/optic-disc-rim-and-peripapillary-chorioretinal-atrophy-in-normal-japanese-eyes-the-kumejima-study
#18
Aiko Iwase, Shoichi Sawaguchi, Hiroshi Sakai, Kenji Tanaka, Tae Tsutsumi, Makoto Araie
PURPOSE: To report reference data for optic disc, neuroretinal rim and β-peripapillary atrophy (β-PPA) in normal Japanese. METHODS: In the Kumejima study, all participants underwent disc stereo-photography; 2208 normal subjects had good-quality disc stereo and β-PPA photographs OU. The disc and rim area and the area and angular extent of β-PPA were evaluated by computer-assisted planimetry. RESULTS: The disc, rim, and β-PPA area and its angular extent OD (OS) averaged 2...
February 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28181118/brain-uptake-and-safety-of-flutemetamol-f-18-injection-in-japanese-subjects-with-probable-alzheimer-s-disease-subjects-with-amnestic-mild-cognitive-impairment-and-healthy-volunteers
#19
Takami Miki, Hiroyuki Shimada, Jae-Seung Kim, Yasuji Yamamoto, Masakazu Sugino, Hisatomo Kowa, Kerstin Heurling, Michelle Zanette, Paul F Sherwin, Michio Senda
OBJECTIVE: This Phase 2 study assessed the performance of positron emission tomography (PET) brain images made with Flutemetamol F 18 Injection in detecting β-amyloid neuritic plaques in Japanese subjects. METHODS: Seventy subjects (25 with probable Alzheimer's disease (pAD), 20 with amnestic mild cognitive impairment (aMCI), and 25 cognitively normal healthy volunteers[HVs]) underwent PET brain imaging after intravenous Flutemetamol F 18 Injection (185 MBq). Images were interpreted as normal or abnormal for neuritic plaque density by each of five non-Japanese and five Japanese readers who were blinded to clinical data...
February 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28179468/neurofilament-as-a-blood-marker-for-diagnosis-and-monitoring-of-primary-progressive-aphasias
#20
Petra Steinacker, Elisa Semler, Sarah Anderl-Straub, Janine Diehl-Schmid, Matthias L Schroeter, Ingo Uttner, Hans Foerstl, Bernhard Landwehrmeyer, Christine A F von Arnim, Jan Kassubek, Patrick Oeckl, Hans-Jürgen Huppertz, Klaus Fassbender, Klaus Fliessbach, Johannes Prudlo, Carola Roßmeier, Johannes Kornhuber, Anja Schneider, Alexander E Volk, Martin Lauer, Adrian Danek, Albert C Ludolph, Markus Otto
OBJECTIVE: To assess the utility of serum neurofilament for diagnosis and monitoring of primary progressive aphasia (PPA) variants. METHODS: We investigated neurofilament light chain (NF-L) levels in blood of 99 patients with PPA (40 with nonfluent variant PPA [nfvPPA], 38 with semantic variant PPA [svPPA], 21 with logopenic variant PPA [lvPPA]) and compared diagnostic performance with that reached by CSF NF-L, phosphorylated neurofilament heavy chain (pNF-H), β-amyloid (Aβ1-42), tau, and phosphorylated tau...
March 7, 2017: Neurology
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