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https://www.readbyqxmd.com/read/29457707/peripheral-neurostimulation-breaks-the-shuffling-steps-patterns-in-parkinsonian-gait-a-double-blind-randomized-longitudinal-study-with-automated-mechanical-peripheral-stimulation
#1
Manuela Galli, Caterina Vicidomini, Ana F Rozin Kleiner, Laura Vacca, Veronica Cimolin, Claudia Condoluci, Fabrizio Stocchi, Maria F DE Pandis
BACKGROUND: The shuffling steps pattern is a typical feature of gait in patients affected by Parkinson's Disease (PD), which progressively reduces their quality of life, being related to the risk of falls in this population. Recently, Automated Mechanical Peripheral Stimulation (AMPS) was presented as an integrative rehabilitative treatment based on peripheral stimulation able to improve the gait spatiotemporal parameters in PD patients. AIM: To evaluate the effects of AMPS on shuffling steps pattern by analyzing the kinematic and spatio-temporal gait parameters...
February 19, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29456337/evaluation-of-predictive-factors-influencing-community-reintegration-in-adult-patients-with-stroke
#2
Olajide Ayinla Olawale, Jibrin Sammani Usman, Kayode Israel Oke, Oladunni Caroline Osundiya
Objectives: Patients with stroke are faced with gait, balance, and fall difficulties which could impact on their community reintegration. In Nigeria, community reintegration after stroke has been understudied. The objective of this study was to evaluate the predictors of community reintegration in adult patients with stroke. Materials and Methods: Participants were 91 adult patients with stroke. Gait variables, balance self-efficacy, community balance/mobility, and fall self-efficacy were assessed using Rivermead Mobility Index, Activities-specific Balance Confidence Scale, Community Balance and Mobility Scale, and Falls Efficacy Scale-International respectively...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455250/systematic-review-and-meta-analysis-of-prevalence-of-sarcopenia-in-post-acute-inpatient-rehabilitation
#3
REVIEW
I Churilov, L Churilov, R J MacIsaac, E I Ekinci
Sarcopenia is associated with poor function and increased risk of falls and disability. This work reports a systematic review and meta-analysis of prevalence of sarcopenia in post acute inpatient rehabilitation. Sarcopenia is found to be present in approximately 50% of rehabilitation patients and its prevalence may vary with admission diagnosis. PURPOSE: To conduct a systematic review and meta-analysis of reported prevalence of sarcopenia in post acute inpatient rehabilitation. METHODS: Systematic review conducted according to PRISMA guidelines (PROSPERO registration number CRD42016054135)...
February 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29454316/the-theoretical-and-empirical-basis-of-a-biopsychosocial-bps-risk-screener-for-detection-of-older-people-s-health-related-needs-planning-of-community-programs-and-targeted-care-interventions
#4
Zoe J-L Hildon, Chuen Seng Tan, Farah Shiraz, Wai Chong Ng, Xiaodong Deng, Gerald Choon Huat Koh, Kelvin Bryan Tan, Ian Philp, Dick Wiggins, Su Aw, Treena Wu, Hubertus J M Vrijhoef
BACKGROUND: This study introduces the conceptual basis and operational measure, of BioPyschoSocial (BPS) health and related risk to better understand how well older people are managing and to screen for risk status. The BPS Risk Screener is constructed to detect vulnerability at older ages, and seeks to measure dynamic processes that place equal emphasis on Psycho-emotional and Socio-interpersonal risks, as Bio-functional ones. We validate the proposed measure and describe its application to programming...
February 17, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29453941/increased-morbidity-and-mortality-associated-with-falls-among-patients-with-cirrhosis
#5
Ghideon Ezaz, Susan L Murphy, Jessica Mellinger, Elliot B Tapper
BACKGROUND: Injuries are more morbid and complicated to manage in patients with cirrhosis. However, data are limited regarding the relative risk of injury and severity of injury from falls in patients with cirrhosis compared to those without cirrhosis. METHODS: We examined the nationally representative National Emergency Department Sample, an all-payer database including all patients presenting with falls 2009-2012. We determined the relative risks for and clinical associations with severe injuries...
February 14, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29453841/beyond-cost-benefit-analysis-in-the-governance-of-synthetic-biology
#6
Wendell Wallach, Marc Saner, Gary Marchant
For many innovations, oversight fits nicely within existing governance mechanisms; nevertheless, others pose unique public health, environmental, and ethical challenges. Synthetic artemisinin, for example, has many precursors in laboratory-developed drugs that emulate natural forms of the same drug. The policy challenges posed by synthetic artemisinin do not differ significantly in kind from other laboratory-formulated drugs. Synthetic biofuels and gene drives, however, fit less clearly into existing governance structures...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29453101/can-higher-training-practice-dosage-with-treadmill-slip-perturbation-necessarily-reduce-risk-of-falls-following-overground-slip
#7
Anna Lee, Tanvi Bhatt, Xuan Liu, Yiru Wang, Yi-Chung Pai
BACKGROUND: Perturbation training is an emerging paradigm to reduce idiopathic falls (without clinical signs or symptoms) in older adults. While a higher threat dosage (intensity) in motor learning often directly relates to greater adaptation, retention, and generalization, little is known whether increasing the practice dosage (repetition) of slip-perturbation training would necessarily improve its outcomes. RESEARCH QUESTION: Can higher practice dosage of treadmill slip-perturbation training lead to greater generalization to an overground slip immediately after the training? METHODS: Forty-five community-dwelling older adults (73...
February 13, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29452785/the-risks-of-sarcopenia-falls-and-fractures-in-patients-with-type-2-diabetes-mellitus
#8
REVIEW
C Sarodnik, S P G Bours, N C Schaper, J P van den Bergh, T A C M van Geel
Fracture risk in patients with type 2 diabetes mellitus (T2DM) is increased, and the mechanism is multifactorial. Recent research on T2DM-induced bone fragility shows that bone mineral density (BMD) is often normal or even slightly elevated. However, bone turnover may be decreased and bone material and microstructural properties are altered, especially when microvascular complications are present. Besides bone fragility, extra-skeletal factors leading to an increased propensity to experience falls may also contribute to the increased fracture risk in T2DM, such as peripheral neuropathy, retinopathy and diabetes medication (e...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29452755/machine-learning-algorithms-based-on-signals-from-a-single-wearable-inertial-sensor-can-detect-surface-and-age-related-differences-in-walking
#9
B Hu, P C Dixon, J V Jacobs, J T Dennerlein, J M Schiffman
The aim of this study was to investigate if a machine learning algorithm utilizing triaxial accelerometer, gyroscope, and magnetometer data from an inertial motion unit (IMU) could detect surface- and age-related differences in walking. Seventeen older (71.5 ± 4.2 years) and eighteen young (27.0 ± 4.7 years) healthy adults walked over flat and uneven brick surfaces wearing an inertial measurement unit (IMU) over the L5 vertebra. IMU data were binned into smaller data segments using 4-s sliding windows with 1-s step lengths...
January 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29452320/the-risk-of-traumatic-brain-injury-occurring-among-patients-with-parkinson-sdisease-a-14-year-population-based-study
#10
Tee-Tau Eric Nyam, Chung-Han Ho, Yu-Lin Wang, Sher-Wei Lim, Jhi-Joung Wang, Chung-Ching Chio, Jinn-Rung Kuo, Che-Chuan Wang
BACKGROUND: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson's disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations. MATERIAL AND METHODS: The study selected 6,076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29451618/the-association-of-vitamin-d-levels-and-the-frailty-phenotype-among-non-geriatric-dialysis-patients-a-cross-sectional-study
#11
Demet Tekdos Demircioglu
OBJECTIVES: The aim of this study was to investigate the frequency of frailty and the association of vitamin D levels and the frailty phenotype among non-geriatric dialysis patients. METHOD: Seventy-four stable, chronic hemodialysis patients from the hemodialysis unit of the hospital were enrolled in the study. The patients' medical histories and laboratory findings were obtained from the medical records of the dialysis unit. Serum parathyroid hormone and 25-hydroxy vitamin D levels were determined using chemiluminometric immunoassays...
2018: Clinics
https://www.readbyqxmd.com/read/29451109/-orthostatic-hypotension-in-elderly-patients
#12
J A H R Claassen
- Orthostatic hypotension is a condition in which there is insufficient recovery of the blood pressure drop which occurs after getting up, which causes a temporary reduction of cerebral perfusion. This increases the risk of falls resulting in injuries.- Orthostatic hypotension is most common in the elderly. The cause is usually multifactorial (including reduced circulating volume, reduced peripheral resistance and limited heart rate increase). Orthostatic hypotension caused by autonomic dysfunction is called neurogenic orthostatic hypotension...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29450911/it-is-important-not-to-assume-an-aetiology-for-the-triad-before-the-outcomes-of-diagnostic-investigations
#13
Jacob Andersson, Ingemar Thiblin
We did not diagnose eight cases with AHT. They were diagnosed by the forensic pathologists who performed the post mortems. Considering that most cases had risk factors for subdural haematoma, such as prematurity, trauma from alleged falls or disease, we argue that some of the cases may have other explanations than AHT for the findings that led to the AHT diagnoses. This article is protected by copyright. All rights reserved.
February 16, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29448219/gait-posture-special-issue-gait-adaptations-in-response-to-obstacle-type-in-fallers-with-parkinson-s-disease
#14
Lisa Alcock, Brook Galna, Jeffrey M Hausdorff, Sue Lord, Lynn Rochester
BACKGROUND: Gait impairment places older adults and people with Parkinson's disease (PD) at an increased risk of falls when walking over obstacles. Increasing the height of obstacles results in greater challenge to balance however little is known about the demands encountered when negotiating obstacles of greater depth which may be greater for PD who often walk with a short, shuffling gait. RESEARCH QUESTION: To describe gait adaptation in older adults and people with PD when walking over long and tall obstacles...
January 31, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29448162/cognitive-motor-dual-task-interference-modulates-mediolateral-dynamic-stability-during-gait-in-post-stroke-individuals
#15
R Tisserand, S Armand, G Allali, A Schnider, S Baillieul
Gait asymmetry and dynamic balance impairments observed in post-stroke individuals increase their risk of fall. Moreover, walking while performing a cognitive task (i.e. dual-task) disturbs the control of balance in post-stroke individuals. Here we investigated the mediolateral dynamic stability in twenty-two community-dwelling participants (12 post-strokes and 10 healthy controls) while walking in single-task (normal gait) and four different dual-tasks (cognitive-motor interference). Positions of the extrapolated center of mass and mediolateral widths of both margin of stability and base of support were extracted from 35 marker trajectories...
February 12, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29444300/deep-brain-stimulation-for-parkinson-disease-does-not-worsen-or-improve-postural-instability-a-prospective-cohort-trial
#16
Nicholas J Brandmeir, Cheryl L Brandmeir, David Carr, Kristine Kuzma, James McInerney
BACKGROUND: Falls and postural instability (PI) are major sources of morbidity in Parkinson disease (PD). Deep brain stimulation (DBS) is a major therapy for PD. The effects of DBS on PI and falls remain controversial. OBJECTIVE: To study if DBS worsens PI, validated measures of PI (Timed Up and Go, Berg Balance Scale, Unified Parkinson's Disease Rating Scale 3.12 [Pull Test], and the Biodex Sway Index with eyes closed on a firm and soft surface) and reported falls were used to prospectively evaluate the effect of DBS on PI at 3 and 12 mo postoperatively compared to baseline measurements...
February 10, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29441104/current-status-of-brachytherapy-in-cancer-treatment-short-overview
#17
REVIEW
Janusz Skowronek
Cancer incidence and mortality depend on a number of factors, including age, socio-economic status and geographical location, and its prevalence is growing around the world. Most of cancer treatments include external beam radiotherapy or brachytherapy. Brachytherapy, a type of radiotherapy with energy from radionuclides inserted directly into the tumor, is increasingly used in cancer treatment. For cervical and skin cancers, it has become a standard therapy for more than 100 years as well as an important part of the treatment guidelines for other malignancies, including head and neck, skin, breast, and prostate cancers...
December 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29440734/dynamics-of-starvation-and-recovery-predict-extinction-risk-and-both-damuth-s-law-and-cope-s-rule
#18
Justin D Yeakel, Christopher P Kempes, Sidney Redner
The eco-evolutionary dynamics of species are fundamentally linked to the energetic constraints of their constituent individuals. Of particular importance is the interplay between reproduction and the dynamics of starvation and recovery. To elucidate this interplay, here we introduce a nutritional state-structured model that incorporates two classes of consumers: nutritionally replete, reproducing consumers, and undernourished, nonreproducing consumers. We obtain strong constraints on starvation and recovery rates by deriving allometric scaling relationships and find that population dynamics are typically driven to a steady state...
February 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29439446/the-t2238c-human-atrial-natriuretic-peptide-molecular-variant-and-the-risk-of-cardiovascular-diseases
#19
REVIEW
Speranza Rubattu, Sebastiano Sciarretta, Simona Marchitti, Franca Bianchi, Maurizio Forte, Massimo Volpe
Atrial natriuretic peptide (ANP) is a cardiac hormone which plays important functions to maintain cardio-renal homeostasis. The peptide structure is highly conserved among species. However, a few gene variants are known to fall within the human ANP gene. The variant rs5065 (T2238C) exerts the most substantial effects. The T to C transition at the 2238 position of the gene (13-23% allele frequency in the general population) leads to the production of a 30-, instead of 28-, amino-acid-long α-carboxy-terminal peptide...
February 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29439376/should-we-consider-steps-with-variable-height-for-a-safer-stair-negotiation-in-older-adults
#20
Marcos R Kunzler, Emmanuel S da Rocha, Christielen S Dos Santos, Fernando G Ceccon, Liver A Priario, Felipe P Carpes
BACKGROUND: Effects of exercise on foot clearances are important. In older adults variations in foot clearances during walking may lead to a fall, but there is a lack of information concerning stair negotiation in older adults. Whether a condition of post exercise changes foot clearances between steps of a staircase in older adults still unknown. OBJECTIVE: To determine differences in clearances when older adults negotiate different steps of a staircase before and after a session of aerobic exercise...
2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
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