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Nt probnp in pregnancy

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https://www.readbyqxmd.com/read/28461601/angiogenic-markers-and-cardiovascular-indices-in-the-prediction-of-hypertensive-disorders-of-pregnancy
#1
Stefan Verlohren, Frank H Perschel, Baskaran Thilaganathan, Lisa Antonia Dröge, Wolfgang Henrich, Andreas Busjahn, Asma Khalil
Angiogenic and antiangiogenic factors have proven to be an accurate predictive means of preeclampsia. Echocardiographic studies have shown that women with preeclampsia exhibit significant cardiovascular strain, especially early-onset preeclampsia. The aim of this study is to determine preeclampsia risk with soluble fms-like tyrosin kinase 1/placental growth factor ratio, serum NT-proBNP (N-terminal pro B-type natriuretic peptide), and biophysical markers of cardiovascular function in a prospective case-control study...
June 2017: Hypertension
https://www.readbyqxmd.com/read/28209494/effect-of-early-onset-preeclampsia-on-cardiovascular-risk-in-the-fifth-decade-of-life
#2
Anouk Bokslag, Pim W Teunissen, Constantijn Franssen, Floortje van Kesteren, Otto Kamp, Wessel Ganzevoort, Walter J Paulus, Christianne J M de Groot
BACKGROUND: Women with hypertensive disorders in pregnancy, in particular early-onset preeclampsia, are at increased risk of developing cardiovascular disease later in life. These women have a more than 2-fold increased risk of dying from cardiovascular diseases. Most studies have focused on identification of risk factors shortly after pregnancy. Less is known on the prevalence of risk factors or actual signs of cardiovascular disease 5-20 years later. The presence of hypertension or metabolic syndrome can be seen as an opportunity for preventive interventions to reduce the development of severe cardiovascular diseases like myocardial infarction and stroke...
May 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28195551/b-type-natriuretic-peptide-and-echocardiography-reflect-volume-changes-during-pregnancy
#3
Janet M Burlingame, Kelly Yamasato, Hyeong Jun Ahn, Todd Seto, W H Wilson Tang
OBJECTIVE: To evaluate B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac structure and function in normal women through pregnancy and the postpartum. METHODS: In this prospective observational study, we obtained serial transthoracic echocardiograms, BNP, and NT-proBNP at seven intervals from 6 weeks' gestation through 12 months postpartum. Women with hypertension or cardiac disease were excluded. Using 6-12 months postpartum as reference for non-pregnant levels, echocardiogram measurements and BNP/NT-proBNP were compared over time using linear mixed models with Tukey-Kramer adjustment for multiple comparisons...
February 14, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28151494/relationship-between-maternal-hemodynamics-and-plasma-natriuretic-peptide-concentrations-during-pregnancy-complicated-by-preeclampsia-and-fetal-growth-restriction
#4
S R Giannubilo, A Pasculli, E Tidu, A Biagini, V Boscarato, A Ciavattini
OBJECTIVE: A proper maternal cardiovascular adaptation to the pregnancy plays a key role for promoting an adequate uteroplacental perfusion, for ensuring normal fetal development and for preventing gestational hypertensive complications such as preeclampsia. This study aims to evaluate hemodynamic measurements obtained by noninvasive methods among preclamptic women with and without fetal growth restriction (FGR) and the relationship with plasma levels of natriuretic peptides. STUDY DESIGN: The study compared 98 pregnant women (n=48 with preeclampsia; n=50 normotensive pregnant women) and 50 nonpregnant normotensive control subjects undergoing anultrasonic cardiac output monitor (USCOM) and plasma assessment of atrial N-terminal pro B-type natriuretic peptide (NT-proBNP)...
February 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27991743/vector-synthesis-high-resolution-electrocardiography-atrial-natriuretic-peptide-and-n-terminal-prohormone-brain-natriuretic-peptide-for-estimation-of-cardiac-load-in-pregnancy
#5
Shino Tanaka, Rie Oyama, Akimune Fukushima, Akihiko Kikuchi, Toru Sugiyama
AIM: We analyzed atrial natriuretic peptide (ANP), N-terminal pro-brain natriuretic natriuretic peptide (NT-proBNP) and vector synthesis high-resolution electrocardiography (ECG), to estimate cardiac load with circulatory dynamic change from pregnancy through the post-partum period. METHODS: The subjects were singleton pregnant women (n = 19), who were divided into three stages: stage 1, 34-36 weeks of gestation; stage 2, 2-6 post-partum days; and stage 3, 1-3 months after delivery...
December 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27685993/prenatal-clinical-assessment-of-nt-probnp-as-a-diagnostic-tool-for-preeclampsia-gestational-hypertension-and-gestational-diabetes-mellitus
#6
Pawel Sadlecki, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
Common complications of pregnancy include preeclampsia (PE), gestational hypertension (GH) and gestational diabetes mellitus (GDM). Hypertensive disorders (PE/GH) and GDM may result in greater maternal, fetal and neonatal morbidity and mortality. Women with PE/GH, one of the most common causes of heart burden in an obstetrical setting, present with elevated serum levels of BNP and NT-proBNP. The aim of this study was to shed more light on the role of NT-proBNP in pathophysiology of PE, GH and GDM. The study included 156 pregnant women with singleton pregnancies...
2016: PloS One
https://www.readbyqxmd.com/read/27677676/early-second-trimester-plasma-levels-of-nt-probnp-in-women-who-subsequently-develop-early-onset-preeclampsia
#7
Katja Junus, Anna-Karin Wikström, Anders Larsson, Matts Olovsson
Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier (n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1-131.9 pg/ml) as women with uncomplicated pregnancy outcomes (n = 43) (53...
October 19, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27614219/normal-amino-terminal-pro-brain-natriuretic-peptide-nt-probnp-values-in-amniotic-fluid
#8
Jorge Andrés Carvajal, Fernando Andrés Ferrer, Francisca Isabel Araya, Ana María Delpiano
INTRODUCTION: Brain natriuretic peptide (BNP) is synthesized by human fetal membranes, both the amnion and chorion. This locally produced BNP inhibits the contraction of the human myometrium, contributing to the maintenance of myometrial quiescence during pregnancy. Reference values for NT-proBNP concentrations in amniotic fluid at different gestational ages have not been completely defined. We aimed to investigate the range of fetal NT-proBNP values in amniotic fluid in normal pregnancy between 17 and 41weeks of gestation...
January 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/27328498/umbilical-arterial-n-terminal-pro-b-type-natriuretic-peptide-levels-in-preeclampsia-fetal-growth-restriction-preterm-birth-and-fetal-distress
#9
J Y Bae, W J Seong
OBJECTIVE: To evaluate fetal cardiopulmonary stress in pregnancies complicated by preeclampsia (PE), fetal growth restriction (FGR), preterm birth (PT), and fetal distress (FD) using umbilical arterial blood N-terminal pro-B-type natriuretic peptide (NT-proBNP). MATERIALS AND METHODS: The study included 146 blood samples that were drawn from umbilical arteries at the time of delivery (20 cases of PE, 11 cases of FGR, 31 cases of PT, 23 cases of FD, and 61 cases of gestational age-matched controls) and analyzed...
2016: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27212845/amino-terminal-pro-brain-natriuretic-peptide-in-children-with-latent-rheumatic-heart-disease
#10
Justin P Zachariah, Twalib Aliku, Amy Scheel, Babar S Hasan, Peter Lwabi, Craig Sable, Andrea Z Beaton
BACKGROUND: Rheumatic heart disease (RHD) is a global cause of early heart failure. Early RHD is characterized by valvar regurgitation, leading to ventricular distention and possible elaboration of amino-terminal pro-brain natriuretic peptide (NT-proBNP). We investigated the ability of NT-proBNP to distinguish cases of latent RHD detected by echocardiographic screening from the controls. MATERIALS AND METHODS: Ugandan children (N = 44, 36% males, mean age: 12 ± 2 years) with latent RHD (cases) and siblings (controls) by echocardiography were enrolled...
May 2016: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/27207959/multimarker-risk-stratification-in-patients-with-acute-myocardial-infarction
#11
Michelle L O'Donoghue, David A Morrow, Christopher P Cannon, Petr Jarolim, Nihar R Desai, Matthew W Sherwood, Sabina A Murphy, Robert E Gerszten, Marc S Sabatine
BACKGROUND: Several biomarkers have individually been shown to be useful for risk stratification in patients with acute myocardial infarction (MI). The optimal multimarker strategy remains undefined. METHODS AND RESULTS: Biomarkers representing different pathobiological axes were studied, including myocardial stress/structural changes (NT-pro B-type natriuretic peptide [NT-proBNP], midregional proatrial natriuretic peptide [MR-proANP], suppression of tumorigenicity 2 [ST2], galectin-3, midregional proadrenomedullin [MR-proADM], and copeptin), myonecrosis (troponin T), and inflammation (myeloperoxidase [MPO], high sensitivity C-reactive protein [hsCRP], pregnancy-associated plasma protein A [PAPP-A], and growth-differentiation factor-15 [GDF-15]), in up to 1258 patients from Clopidogrel as Adjunctive Reperfusion Therapy-Thrombolysis in Myocardial Infarction 28 (CLARITY-TIMI 28), a randomized trial of clopidogrel in ST-elevation MI (STEMI)...
May 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27096950/the-association-between-n-terminal-pro-brain-natriuretic-peptide-levels-in-the-umbilical-vein-and-amniotic-fluid-volume-abnormalities
#12
Ali Ozgur Ersoy, Sibel Ozler, Efser Oztas, Ebru Ersoy, Merve Ergin, Salim Erkaya, Dilek Uygur
Purpose The amniotic fluid volume (AFV) is known as a predictor for the wellness of a fetus. We aimed to investigate whether N-terminal pro-brain natriuretic peptide (NTproBNP) levels reflect AFV abnormalities in otherwise normal fetuses. Methods We recruited 24 women with isolated oligohydramnios, 23 women with isolated polyhydramnios, and 36 women with normal AFV at a tertiary referral center. NT-proBNP levels in umbilical venous samples and the individual characteristics of the three groups were compared...
April 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/26991598/serum-levels-of-cardiac-markers-nt-proanp-and-nt-probnp-in-brachycephalic-bitches-at-different-gestational-stages
#13
Mar Feliciano, R R Uscategui, G S Maciel, V T de Almeida, M F Silveira, Gac de Oliveira, Wrr Vicente
The aim of this study was to determine serum levels of natriuretic peptide precursors (NT-proANP and NT-proBNP) during pregnancy in brachycephalic bitches. Fifteen healthy multiparous bitches were selected for this prospective study. Serum levels of NT-proANP and NT-proBNP were measured during anoestrous and at 14, 35, 42, 49 and 56 days (2nd, 5th, 6th, 7th and 8th weeks) of pregnancy. Fourteen animals had normal gestations, and one bitch developed single foetus syndrome. The natriuretic peptide levels of this animal were not included in this study; however, it is important to report that its NT-proANP levels were four times greater than those of normal patients...
June 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/26913861/abnormal-maternal-echocardiographic-findings-in-triplet-pregnancies-presenting-with-dyspnoea
#14
Marie Elhenicky, Klaus Distelmaier, Mariella Mailath-Pokorny, Christof Worda, Martin Langer, Katharina Worda
OBJECTIVE: The objective of our study was to evaluate the prevalence of abnormal maternal echocardiographic findings in triplet pregnancies presenting with dyspnoea. STUDY DESIGN: Between 2003 and 2013, patients' records of 96 triplet pregnancies at our department were analysed including maternal and fetal outcome, echocardiographic parameters and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. After exclusion of triplet pregnancies with fetal demise before 23 + 0 weeks, selective feticide or missing outcome data, the study population consisted of 60 triplet pregnancies...
March 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/26444727/association-of-serum-n-terminal-pro-brain-natriuretic-peptide-levels-with-the-severity-of-preeclampsia
#15
Murat Bakacak, Salih Serin, Onder Ercan, Bülent Köstü, Zeyneb Bakacak, Hakan Kiran
OBJECTIVE: To investigate whether serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels could be used as a marker to determine the severity of preeclampsia. METHODS: This prospective cohort study included pregnant women with preeclampsia and severe preeclampsia and normotensive pregnant controls admitted between January 2013 and July 2014. Preeclampsia was graded according to the recently revised criteria of the American College of Obstetricians and Gynecologists (ACOG)...
September 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26293764/serum-biomarkers-of-inflammation-fibrosis-and-cardiac-function-in-facilitating-diagnosis-prognosis-and-treatment-of-anti-ssa-ro-associated-cardiac-neonatal-lupus
#16
Amit Saxena, Peter M Izmirly, Sung Won Han, Paraskevi Briassouli, Tania L Rivera, Hua Zhong, Deborah M Friedman, Robert M Clancy, Jill P Buyon
BACKGROUND: Cardiac manifestations of neonatal lupus (cardiac NL) include congenital heart block and cardiomyopathy. Several candidate biomarkers were evaluated in cases at risk for cardiac NL on the basis of potential roles in inflammation, fibrosis, and cardiac dysfunction: C-reactive protein (CRP); NT-pro-B-type natriuretic peptide (NT-proBNP); troponin I; matrix metalloproteinase (MMP)-2; urokinase plasminogen activator (uPA); urokinase plasminogen activator receptor (uPAR); plasminogen; and vitamin D...
August 25, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/26105429/pp107-cardiovascular-parameters-40-years-after-hypertensive-pregnancies
#17
M Hellgren, A-C Collen, K Manhem
INTRODUCTION: Epidemiological data indicate an increased cardiovascular risk in women with previous hypertensive pregnancies. There are few clinical investigations regarding the mechanisms that could mediate this increased risk. OBJECTIVES: The aim of the present study was to clarify if any deterioration in the cardiovascular, metabolic or neuroendocrine status is present in women 40 years after pregnancies complicated by hypertension. METHODS: Three hundred and nineteen women were invited to take part in a follow up investigation regarding cardiovascular regulation...
July 2012: Pregnancy Hypertension
https://www.readbyqxmd.com/read/26104250/association-of-nt-probnp-with-plasma-renin-activity-and-plasma-aldosterone-concentration-in-women-with-singleton-pregnancy
#18
Takashi Yamada, Takahiro Koyama, Itsuko Furuta, Masamitsu Takeda, Ryutaro Nishida, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami
OBJECTIVE: To determine the association of the N-terminal fragment of precursor protein brain-type natriuretic peptide (NT-proBNP) levels with plasma renin activity (PRA) and plasma aldosterone concentration (PAC) in singleton pregnancies. DESIGN: Serum NT-proBNP levels, PRA and PAC were determined in 215 blood specimens from 139 women with singleton pregnancies, including 34 and 105 women who did and did not develop hypertensive disorders in pregnancy, respectively...
January 2014: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25641540/cardiac-function-and-cardiac-events-1-year-postpartum-in-women-with-congenital-heart-disease
#19
MULTICENTER STUDY
Marlies A M Kampman, Ali Balci, Henk Groen, Arie P J van Dijk, Jolien W Roos-Hesselink, Joost P van Melle, Krystyna M Sollie-Szarynska, Elly M C J Wajon, Barbara J M Mulder, Dirk J van Veldhuisen, Petronella G Pieper
BACKGROUND: Pregnancy is increasingly common in women with congenital heart disease (CHD), but little is known about long-term cardiovascular outcome after pregnancy in these patients. We studied the incidence of cardiovascular events 1-year postpartum and compared cardiac function prepregnancy and 1-year postpartum in women with CHD. METHODS: From our national, prospective multicenter cohort study, 172 women were studied. Follow-up with clinical evaluation and echocardiography and NT-proBNP measurement were performed during pregnancy and 12 months postpartum...
February 2015: American Heart Journal
https://www.readbyqxmd.com/read/25490554/reference-intervals-for-n-terminal-pro-b-type-natriuretic-peptide-in-amniotic-fluid-between-10-and-34-weeks-of-gestation
#20
Waltraut M Merz, Christina Leufgen, Rolf Fimmers, Birgit Stoffel-Wagner, Ulrich Gembruch
BACKGROUND: In adult and pediatric cardiology, n-terminal pro-B-type natriuretic peptide (nt-proBNP) serves as biomarker in the diagnosis and management of cardiovascular dysfunction. Elevated levels of circulating nt-proBNP are present in fetal conditions associated with myocardial pressure or volume load. Compared to fetal blood sampling, amniocentesis is technically easier and can be performed from early pregnancy onwards. We aimed to investigate amniotic fluid (AF) nt-proBNP concentrations in normal pregnancies between 10 and 34 weeks of gestation...
2014: PloS One
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