Yiliang Yang, Yiwei Peng, Yitian Du, Meng Lin, Jiajia Li, Datong Gao, Zhenzhen Yang, Wei Wang, Yanxia Zhou, Xinru Li, Taiqiang Yan, Xianrong Qi
Cancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by combining chemotherapy and photodynamic therapy (PDT)...
April 15, 2024: Biomaterials