Herma C Pierre, Chiraz Soumia M Amrine, Michael G Doyle, Amrita Salvi, Huzefa A Raja, Jonathan R Chekan, Andrew C Huntsman, James R Fuchs, Kebin Liu, Joanna E Burdette, Cedric J Pearce, Nicholas H Oberlies
Covering: 1970 through June of 2023Verticillins are epipolythiodioxopiperazine (ETP) alkaloids, many of which possess potent, nanomolar-level cytotoxicity against a variety of cancer cell lines. Over the last decade, their in vivo activity and mode of action have been explored in detail. Notably, recent studies have indicated that these compounds may be selective inhibitors of histone methyltransferases (HMTases) that alter the epigenome and modify targets that play a crucial role in apoptosis, altering immune cell recognition, and generating reactive oxygen species...
April 17, 2024: Natural Product Reports