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https://www.readbyqxmd.com/read/28651314/stabilization-of-heavy-metals-in-soil-using-two-organo-bentonites
#1
Kai Yu, Jian Xu, Xiaohong Jiang, Cun Liu, Wesley McCall, Jinlong Lu
Stabilization of Cu, Zn, Cd, Hg, Cr and As in soil using tetramethylammonium (TMA) and dodecyltrimethylammonium (DTMA) modified bentonites (T-Bents and D-Bents) as amendments was investigated. Toxicity characteristic leaching procedure (TCLP) was used to quantify the metal mobility after soil treatment. The structural parameters of modified bentonites, including the BET surface area, basal spacing and zeta potential were obtained as a function of the TMA and DTMA loading at 40, 80, 120, 160 and 200% of the bentonite's cation exchange capacity, respectively...
June 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28651246/development-of-a-perfusion-platform-for-dynamic-cultivation-of-in-vitro-skin-models
#2
Kay Strüver, Wolfgang Friess, Sarah Hedtrich
Reconstructed skin models are suitable test systems for toxicity testing and for basic investigations on (patho-)physiological aspects of human skin. Reconstructed human skin, however, has clear limitations such as the lack of immune cells and a significantly weaker skin barrier function compared to native human skin. Potential reasons for the latter might be the lack of mechanical forces during skin model cultivation which is performed classically in static well-plate setups. Mechanical forces and shear stress have a major impact on tissue formation and, hence, tissue engineering...
June 27, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28651198/the-toxicity-of-cationic-surfactant-hdtma-br-desorbed-from-surfactant-modified-zeolite-towards-faecal-indicator-and-environmental-microorganisms
#3
Peter J Reeve, Howard J Fallowfield
Surfactant Modified Zeolite (SMZ) represents a versatile, cost-effective permeable reactive material, capable of treating multiple classes of contaminants. The potential for HDTMA-Br, a cationic surfactant commonly used to modify zeolite, to desorb from the zeolite surface has been identified as a potential issue for the ongoing use of SMZ in water remediation contexts. This paper investigates the toxicity of HDTMA-Br towards enteric virus surrogates, F-RNA bacteriophage MS2 and E. coli, Bacillus subtilis, and soil microflora...
June 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28651197/ascorbic-acid-protects-coccomyxa-subellipsoidea-against-metal-toxicity-through-modulation-of-ros-no-balance-and-metal-uptake
#4
Jozef Kováčik, Gabriela Rotková, Marek Bujdoš, Petr Babula, Viera Peterková, Peter Matúš
Impact of exogenous ascorbic acid (AsA, 100μM) on acute metal toxicity (Pb and Hg, 24h of exposure to 100μM) in unicellular green alga Coccomyxa subellipsoidea was studied. Hg (often extensively) depleted amount of pigments, potassium, soluble proteins, endogenous AsA, non-protein thiols and nitric oxide signal but elevated ROS signal and activities of catalase and superoxide dismutase. Responses to Pb application (if any) were less visible with ROS signal being slightly elevated and amount of non-protein thiols being slightly reduced...
June 16, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28651192/efficient-photocatalytic-degradation-of-toxic-dyes-from-aqueous-environment-using-gelatin-zr-iv-phosphate-nanocomposite-and-its-antimicrobial-activity
#5
Manita Thakur, Gaurav Sharma, Tansir Ahamad, Ayman A Ghfar, Deepak Pathania, Mu Naushad
In the present study, gelatin-Zr(IV) phosphate nanocomposite (GT/ZPNC) was synthesized by sol-gel method by mixing the gelatin gel into the inorganic part Zr (IV) phosphate (ZP). The GT/ZPNC was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy (SEM), transmission electron micron scope (TEM), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The photodegradation activity of GT/ZPNC was explored for the removal of methylene blue (MB) and fast green (FG) dyes from aqueous solution...
June 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28651190/temporal-dynamics-of-the-compositions-and-activities-of-soil-microbial-communities-post-application-of-the-insecticide-chlorantraniliprole-in-paddy-soils
#6
Meng Wu, Jia Liu, Weitao Li, Ming Liu, Chunyu Jiang, Zhongpei Li
Chlorantraniliprole (CAP) is a newly developed insecticide widely used in rice fields in China. There has been few studies evaluating the toxicological effects of CAP on soil-associated microbes. An 85-day microcosm experiment was performed to reveal the dissipation dynamics of CAP in three types of paddy soils in subtropical China. The effects of CAP on microbial activities (microbial biomass carbon-MBC, basal soil respiration-BSR, microbial metabolic quotient-qCO2, acid phosphatase and sucrose invertase activities) in the soils were periodically evaluated...
June 23, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28651182/chronic-effects-of-atrazine-exposure-and-recovery-in-freshwater-benthic-diatoms-from-two-communities-with-different-pollution-histories
#7
Rebecca J Wood, Simon M Mitrovic, Richard P Lim, Ben J Kefford
Diffuse agricultural runoff into rivers can result in contamination with herbicides for prolonged periods of time. Chronic exposure to herbicides has the potential to alter toxic impacts in primary producers such as benthic diatoms. Determining how individual diatom taxa respond to herbicide exposure over varied exposure durations is essential for assessing herbicide impacts. This study investigated the responses of various benthic diatom taxa and effects at the community level over 12days of atrazine exposure...
June 19, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28651181/antifouling-biocides-impairment-of-bivalve-immune-system-by-chlorothalonil
#8
Amanda da Silveira Guerreiro, Regina Coimbra Rola, Monique Tomazele Rovani, Simone Rutz da Costa, Juliana Zomer Sandrini
Marine ecosystems are subjected to a variety of contaminants. Antifouling paints, for example, have been extensively used to protect ship surfaces from marine biofouling, but their toxicity has generated great concern. Thus, we evaluated the effect of the biocide chlorothalonil on the immune system of Perna perna mussels. The mussels were exposed to 0 (control), 0.1μg/L and 10μg/L of chlorothalonil for up to 96h. After 24h and 96h of exposure, the following immune-related parameters were analyzed in the hemolymph of mussels: total hemocyte count, cell adhesion, phagocytic activity, level of reactive oxygen species, cell viability and comet assay...
June 16, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28651172/simultaneous-determination-of-cis-permethrin-and-trans-permethrin-in-rat-plasma-and-brain-tissue-using-gas-chromatography-negative-chemical-ionization-mass-spectrometry
#9
Shirin Hooshfar, Darren R Gullick, Michael R Linzey, Tanzir Mortuza, Mona Hamdy Abdel Rahman, Clinton A Rogers, James V Bruckner, Catherine A White, Michael G Bartlett
A sensitive method for the simultaneous determination of cis-permethrin (cis-PERM) and trans-permethrin (trans-PERM) in small volumes (100μL) of rat plasma and brain homogenate was developed, using a liquid-liquid extraction for sample preparation and gas chromatography-negative chemical ionization mass spectrometry (GCNCI-MS) for detection. Quantitation of trace levels of the insecticide in small volumes of biological samples is essential to support toxicokinetic studies in small animals. There are currently no validated methods in the literature for determining cis-PERM and trans- PERM in volumes as low as 100μL of rat plasma or brain homogenate...
June 13, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28651164/serum-levels-of-decabromodiphenyl-ether-bde-209-in-women-from-different-european-countries-and-possible-relationships-with-lifestyle-and-diet
#10
Martin van den Berg, Remko Houba, Heather A Leslie, Rocio F Canton, Cathrine Thomsen, Georg Becher, Mar Alvarez-Pedrerol, Jordi Sunyer Deu, Markus Steiner, Martie van Tongeren, Bert Brunekreef, Jacob de Boer
To determine possible effects of lifestyle, diet, housing and professional activities on differences in individual levels of decabromodiphenyl ether (BDE-209) in serum of women, 20 to 40years of age, in The Netherlands, the United Kingdom, Norway and Spain. BDE-209 was measured in serum of 145 female volunteers with no known occupational exposure from Norway, United Kingdom, The Netherlands and Spain. Blood levels of BDE-209 in a subgroup of 40 Dutch women were determined twice at a six months' interval. An extensive questionnaire was used to obtain detailed information about lifestyle factors that might contribute to BDE-209 exposure...
June 23, 2017: Environment International
https://www.readbyqxmd.com/read/28651161/connexin-43-mediates-changes-in-protein-phosphorylation-in-hk-2-cells-during-chronic-cadmium-exposure
#11
Zehe Ge, Haipeng Diao, Maohui Yu, Xiaoli Ji, Qingping Liu, Xiuli Chang, Qing Wu
Connexin 43 (Cx43) is believed to play a role in the mechanisms of toxicity of many chemical species, include cadmium (Cd). In this study, human renal proximal tubule (HK-2) cells were exposed to Cd (1μM, 10 days). Of the 584 protein residues detected using a Phospho Explorer antibody microarray (PEX100), more than half changed their levels of phosphorylation after chronic Cd exposure. Cx43 siRNA attenuated Cd-induced apoptosis and inhibited proliferation, while also attenuating changes in the levels of phosphorylation of many protein residues...
June 20, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28651154/new-comprehensive-studies-of-a-gold-iii-dithiocarbamate-complex-with-proven-anticancer-properties-aqueous-dissolution-with-cyclodextrins-pharmacokinetics-and-upstream-inhibition-of-the-ubiquitin-proteasome-pathway
#12
Marianna F Tomasello, Chiara Nardon, Valeria Lanza, Giuseppe Di Natale, Nicolò Pettenuzzo, Stefano Salmaso, Danilo Milardi, Paolo Caliceti, Giuseppe Pappalardo, Dolores Fregona
The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with our efforts for unravelling its tangled mechanism of action. We used three types of α-cyclodextrins (CDs), namely β-CD, Me-β-CD and HP-β-CD to prepare aqueous solutions of AuL12...
June 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28651117/mantle-cell-lymphoma-current-standards-of-care-and-future-directions
#13
REVIEW
Peter Martin, Paola Ghione, Martin Dreyling
Over the past decade we have seen significant changes in the biological characterization and strategies for treatment of mantle cell lymphoma (MCL). MCL is heterogeneous a disease, and so are the people that have it; although guidelines are appropriate, therapeutic approaches must be individualized based on a variety of factors. In this review, we summarize data on the range of therapeutic options, from observation in patients with slowly progressive low-tumor-burden MCL, to bendamustine-based regimens in typical MCL, to high-dose cytarabine-based regimens in young, fit patients...
June 13, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28651089/validation-of-commercial-real-time-pcr-arrays-for-environmental-risk-assessment-application-to-the-study-of-p-p%C3%A2-dde-toxicity-in-mus-spretus-mice-liver
#14
Noelia Morales-Prieto, Carmen Pueyo, Nieves Abril
Data on gene transcription profiles provide a comprehensive assessment of the toxic and defensive mechanisms that are triggered by pollutants. PCR-arrays have emerged as a reliable tool for analyzing the expression of a panel of relevant, pathway- or disease-focused genes under uniform cycling conditions. By using SYBR Green-optimized primer assays, it is possible to simultaneously amplify a sample with high specificity and amplification efficiencies. However, commercial PCR-arrays target a limited group of organisms, excluding most of those with environmental relevance, as is the case with Mus spretus mice...
June 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28651088/genetic-and-epigenetic-alterations-in-normal-and-sensitive-copd-diseased-human-bronchial-epithelial-cells-repeatedly-exposed-to-air-pollution-derived-pm2-5
#15
B Leclercq, A Platel, S Antherieu, L Y Alleman, E M Hardy, E Perdrix, N Grova, V Riffault, B M Appenzeller, M Happillon, F Nesslany, P Coddeville, J-M Lo-Guidice, G Garçon
Even though clinical, epidemiological and toxicological studies have progressively provided a better knowledge of the underlying mechanisms by which air pollution-derived particulate matter (PM) exerts its harmful health effects, further in vitro studies on relevant cell systems are still needed. Hence, aiming of getting closer to the human in vivo conditions, primary human bronchial epithelial cells derived from normal subjects (NHBE) or sensitive chronic obstructive pulmonary disease (COPD)-diseased patients (DHBE) were differentiated at the air-liquid interface...
June 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28651077/rhizopus-oryzae-ancient-microbial-resource-with-importance-in-modern-food-industry
#16
REVIEW
Liliana Londoño-Hernández, Cristina Ramírez-Toro, Héctor A Ruiz, Juan A Ascacio-Valdés, Miguel A Aguilar-Gonzalez, Raúl Rodríguez-Herrera, Cristóbal N Aguilar
Filamentous fungi are microorganisms widely known for their diverse biochemical features. Fungi can efficiently invade a wide variety of substrates under operational conditions producing numerous bioproducts of interest, such as enzymes, organic acids, aromatic compounds and colorants. An additional interesting characteristic of some fungi is their safety classification for different uses, which guarantees that the bioproducts obtained from them do not contain any toxic component deleterious to humans. Rhizopus oryzae is among this group of fungi and is classified as a GRAS filamentous fungus, commonly used for production of some oriental traditional foods...
June 15, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28651074/chimeric-antigen-receptor-engineered-natural-killer-and-natural-killer-t-cells-for-cancer-immunotherapy
#17
REVIEW
Dominique Bollino, Tonya J Webb
Natural killer (NK) cells of the innate immune system and NK T (NKT) cells, which have roles in both the innate and adaptive responses, are unique lymphocyte subsets that have similarities in their functions and phenotypes. Both cell types can rapidly respond to the presence of tumor cells and participate in immune surveillance and antitumor immune responses. This has incited interest in the development of novel cancer therapeutics based on NK and NKT cell manipulation. Chimeric antigen receptors (CARs), generated through the fusion of an antigen-binding region of a monoclonal antibody or other ligand to intracellular signaling domains, can enhance lymphocyte targeting and activation toward diverse malignancies...
June 9, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28651066/thalassemia-major-transfusion-and-chelation-or-transplantation
#18
REVIEW
Said Yousuf Mohamed
Thalassemia is the most common monogenic hematologic disease that affects millions in the world and kills thousands of patients every year. Without transfusion or transplantation, patients with thalassemia major are expected to die within months of diagnosis. However, long-term transfusion and chelation therapy is highly challenging for many developing countries where the disease is prevalent, representing a major and unsustainable health burden. Stem cell transplantation is the only cure for thalassemia. It has witnessed major developments that have made it less toxic, more successful, and feasible for a larger number of patients with diverse comorbidities and from a wider range of donors...
June 20, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28650983/differential-induction-of-apoptosis-and-autophagy-by-pyrrolizidine-alkaloid-clivorine-in-human-hepatoma-huh-7-5-cells-and-its-toxic-implication
#19
Wenju Liu, Xu Li, Bo Zhou, Shoucai Fang, Wenzhe Ho, Hui Chen, Hao Liang, Li Ye, Jun Tang
Growing evidence suggests that the pyrrolizidine alkaloids (PAs)-induced hepatotoxicity is mediated by multiple cell death/defence modalities. However, the detailed mechanisms are still lacking. In this study, the hepatotoxic effects of four PAs including three retronecine-type ones (senecionine, seneciphylline and monocrotaline) and one otonecine-type (clivorine) on the proliferation of Huh-7.5 cells and the possible mechanisms were investigated. The results showed that all the PAs could inhibit cell proliferation and induce apoptosis in a concentration-dependent manner...
2017: PloS One
https://www.readbyqxmd.com/read/28650900/a-high-throughput-hplc-ms-ms-assay-for-the-detection-quantification-and-simultaneous-structural-confirmation-of-136-drugs-and-metabolites-in-human-urine
#20
Jacek Klepacki, Baharak Davari, Marion Boulet, Ryan Lizarraga, Uwe Christians
BACKGROUND: Due to its superior sensitivity and specificity, multi-analyte high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) has become the gold standard in clinical toxicology. Although several qualitative and quantitative LC-MS/MS assays on various mass spectrometry platforms have been described in the literature, the majority of these methods either analyze only a limited number of compounds, and/or require tedious and time-consuming sample preparation...
June 22, 2017: Therapeutic Drug Monitoring
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