keyword
https://read.qxmd.com/read/38496687/pd-l1-mrna-derived-from-tumor-educated-platelets-as-a-potential-immunotherapy-biomarker-in-non-small-cell-lung-cancer
#21
JOURNAL ARTICLE
Zhihuang Hu, Na Wang, Yao Zhang, Daoyun Zhang, Si Sun, Hui Yu, Ying Lin, Xinmin Zhao, Huijie Wang, Xianghua Wu, Yoshinobu Ichiki, Satoshi Watanabe, Ziying Gong, Jianhua Chang, Jialei Wang
BACKGROUND: To date, the role of programmed death ligand-1 (PD-L1) messenger RNA (mRNA) derived from tumor-educated platelets (TEPs) has not been well investigated in patients with advanced non-small cell lung cancer (NSCLC). A few reports have examined whether mRNA in TEPs can predict the clinical responses of patients with advanced NSCLC following immunotherapy. This study aimed to identify novel biomarkers to improve the clinical benefits and outcomes of NSCLC patients. METHODS: Advanced NSCLC patients receiving a combination of immunotherapy and chemotherapy, or immunotherapy alone as a first- or second-line treatment at the Fudan University Shanghai Cancer Center were enrolled in this study...
February 29, 2024: Translational Lung Cancer Research
https://read.qxmd.com/read/38496406/a-randomized-proof-of-mechanism-trial-of-tnf-antagonism-for-motivational-anhedonia-and-related-corticostriatal-circuitry-in-depressed-patients-with-high-inflammation
#22
Michael Treadway, Sarah Etuk, Jessica Cooper, Shabnam Hossein, Emma Hahn, Samantha Betters, Shiyin Liu, Amanda Arulpragasam, Brittany DeVries, Nadia Irfan, Makiah Nuutinen, Evanthia Wommack, Bobbi Woolwine, Mandakh Bekhbat, Philip Kragel, Jennifer Felger, Ebrahim Haroon, Andrew Miller
Chronic, low-grade inflammation has been associated with motivational deficits in patients with major depression (MD). In turn, impaired motivation has been linked to poor quality of life across psychiatric disorders. We thus determined effects of the anti-inflammatory drug infliximab-a potent tumor necrosis factor (TNF) antagonist-on behavioral and neural measures of motivation in 42 medically stable, unmedicated MD patients with a C-reactive protein > 3mg/L. All patients underwent a double-blind, placebo-controlled, single-dose, randomized clinical trial with infliximab (5mg/kg) versus placebo...
March 5, 2024: Research Square
https://read.qxmd.com/read/38496167/patients-expectations-in-emergency-department-at-king-abdulaziz-university-hospital-a-cross-sectional-survey-based-study
#23
JOURNAL ARTICLE
Ahmad H Bakhribah, Ghaida A Eissa, Dania W Alsulami, Marah A Alotaibi, Htoun M Abdulmannan, Imad M Khojah
BACKGROUND: Emergency departments (EDs) are vital to the timely and necessary care that a significant percentage of patients get. Emergency medicine places a high priority on quality, and to deliver patient-centered care, it is crucial to first investigate patient expectations from ER visits. METHODOLOGY: This is a cross-sectional study of all visits to the King Abdulaziz University Hospital Emergency Department in Jeddah. The study included adult patients who visited the emergency department and were willing to complete a survey and participate in an interview...
February 2024: Curēus
https://read.qxmd.com/read/38496157/the-role-of-diet-in-the-management-of-irritable-bowel-syndrome-a-comprehensive-review
#24
REVIEW
Maleesha Jayasinghe, Vinuri Karunanayake, Ali Mohtashim, Dilushini Caldera, Piyalka Mendis, Omesh Prathiraja, Fatemeh Rashidi, John A Damianos
Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder that has a significant impact on the general population. The suboptimal medical treatments available for IBS contribute to its large economic burden. The pathophysiology of IBS is complex, and treatments often focus on managing specific symptoms. Many individuals with IBS associate their symptoms with specific food intake, leading to increased scientific research on the role of diet in managing IBS. Dietary management has become a crucial aspect of IBS treatment, with initial recommendations focusing on adopting a healthy eating pattern and lifestyle...
February 2024: Curēus
https://read.qxmd.com/read/38496147/enhancing-nuclear-medicine-practice-in-saudi-arabia-advocating-for-comprehensive-guidelines-and-local-diagnostic-reference-levels
#25
JOURNAL ARTICLE
Sarah K Albahiti, Mawya Khafaji, Nadiya Batawil, Norwin Catipay, Khalid Alsafi
INTRODUCTION:  Diagnostic reference levels (DRLs) were initially introduced by the International Commission on Radiation Protection (ICRP). It refers to the measured quantity of administered activity (MBq) in nuclear medicine imaging studies and is a type of investigation level. DRL is recommended to prevent excessive radiation exposure to patients while maintaining adequate image quality. It should not be implemented as a dose constraint or dose limit. The Saudi Food and Drug Authority (SFDA) is the primary government body responsible for reporting national diagnostic reference levels (NDRLs) for diagnostic medical imaging technologies in Saudi Arabia...
February 2024: Curēus
https://read.qxmd.com/read/38496123/study-on-vitamin-d-levels-in-30-to-40-year-old-females-with-low-back-pain
#26
JOURNAL ARTICLE
Nimisha V, Gautham G Nair, Biju C Jose, Angel Abraham
BACKGROUND: Vitamin D is associated with many skeletal-related processes in the body. A major health problem concerning decreased quality of life is chronic low back pain (LBP). Many studies have proved that chronic pain improves with Vitamin D supplementation. This study aimed to explore the correlation between vitamin D levels and the occurrence of LBP in women aged 30 to 40. MATERIALS AND METHODS: A case-control study was taken up at PK Das Institute of Medical Sciences wherein 50 cases (women aged 30-34 years who had chronic LBP >3 months) and 50 age-matched controls were included...
February 2024: Curēus
https://read.qxmd.com/read/38496093/factors-influencing-medical-interns-choice-of-hospital-for-training-saudi-arabia-a-cross-sectional-study
#27
JOURNAL ARTICLE
Farooq U Pasha, Roaa Aljumaa, Ghada Almasri, Miral Atout, Joudi Baladi
Background High-quality, adequately resourced, and strategically oriented medical internship training plays a pivotal role in the continual growth of junior doctors. Evaluating the perspectives of final-year medical students regarding their internship year and their preferred placement is of paramount importance. This study aims to furnish internship programs with valuable insights into interns' perceptions and attitudes toward an optimal internship experience. By doing so, we aim to empower internship programs with the necessary knowledge to enhance their offerings, ensuring they are better tailored to the needs and preparation of future doctors...
February 2024: Curēus
https://read.qxmd.com/read/38496089/creation-of-a-national-emergency-medicine-medical-education-journal-club
#28
JOURNAL ARTICLE
Jessica Pelletier, James Ahn, Andrew Golden, Caroline Astemborski, Michelle D Lall, Albert Kim, Sara Dimeo
Background There are a relatively limited number of emergency medicine (EM) medical education (MedEd) fellowships with few trainees at each program, creating barriers to local collaboration and networking. While best practices for developing MedEd journal clubs exist, there has not been an established national EM MedEd journal club. To address this need, we created a national journal club, the Council of Residency Directors (CORD) MedEd Journal Club (MEJC), to facilitate collaboration and networking opportunities by providing a synchronous online journal club...
February 2024: Curēus
https://read.qxmd.com/read/38496064/the-role-of-tranexamic-acid-in-sleeve-gastrectomy-a-systematic-review-and-meta-analysis
#29
REVIEW
Abdulkreem Al-Juhani, Galal F Sharaf, Saeed Aseri, Hadeel Alosaimi, Shaden A Alharkan, Joud K AlGhamdi, Faris S Hariri, Lojain Daak, Ikhlas Daak
Tranexamic acid (TXA) is an essential procoagulant drug used in various intra- and postoperative situations. Its efficacy and safety profile in obese cases undergoing laparoscopic sleeve gastrectomy (LSG) is still unresolved. Therefore, this meta-analysis evaluated and investigated the current intra- and postoperative effects and hazards of TXA on patients undergoing LSG. As for methodology, Web of Science, Cochrane Library, Scopus, and PubMed were thoroughly searched for relevant studies. Retrieved results were prepared for screening through Endnote, helping to identify eligible studies...
February 2024: Curēus
https://read.qxmd.com/read/38496059/examination-of-the-dundee-ready-educational-environment-measure-dreem-model-based-educational-quality-in-the-clinical-divisions-of-semnan-university-a-descriptive-study
#30
JOURNAL ARTICLE
Shaghayegh Pazoki, Maryam Hajiahmadi, Elham Saffarieh
INTRODUCTION: It is widely recognized that there is a significant correlation between the quality of the learning environment and the level of satisfaction and achievement of students. To enhance the quality of education, it is vital to discern and rectify any inadequacies or deficiencies within the learning environment. Since the examination of strengths and weaknesses of the clinical learning environment provides valuable information to educational managers in improving the quality of education, the primary objective of this study was to examine the educational atmosphere prevalent in the principal clinical departments of the academic medical centers affiliated with Semnan University of Medical Sciences...
February 2024: Curēus
https://read.qxmd.com/read/38496028/six-sigma-evaluation-of-17-biochemistry-parameters-using-bias-calculated-from-internal-quality-control-and-external-quality-assurance-data
#31
JOURNAL ARTICLE
Tülay Çevlik, Goncagül Haklar
BACKGROUND: Six Sigma is a popular quality management system that enables continuous monitoring and improvement of analytical performance in the clinical laboratory. We aimed to calculate sigma metrics and quality goal index (QGI) for 17 biochemical analytes and compare the use of bias from internal quality control (IQC) and external quality assurance (EQA) data in the calculation of sigma metrics. METHODS: This retrospective study was conducted in Marmara University Pendik E&R Hospital Biochemistry Laboratory...
January 25, 2024: Journal of Medical Biochemistry
https://read.qxmd.com/read/38496022/artificial-intelligence-in-the-pre-analytical-phase-state-of-the-art-and-future-perspectives
#32
JOURNAL ARTICLE
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J Favaloro
The use of artificial intelligence (AI) has become widespread in many areas of science and medicine, including laboratory medicine. Although it seems obvious that the analytical and post-analytical phases could be the most important fields of application in laboratory medicine, a kaleidoscope of new opportunities has emerged to extend the benefits of AI to many manual labor-intensive activities belonging to the pre-analytical phase, which are inherently characterized by enhanced vulnerability and higher risk of errors...
January 25, 2024: Journal of Medical Biochemistry
https://read.qxmd.com/read/38496005/quality-of-life-and-glucose-regulation-in-pediatric-patients-with-type-1-diabetes-a-study-in-the-ningxia-hui-autonomous-region
#33
JOURNAL ARTICLE
Hua Bai, Na He, Yan Zhang, Aqsa Ahmad, Xing-Xing Yang, Yan Ma, Li-Jun Liang
OBJECTIVE: In this study, we aimed to evaluate the current status of the quality of life (QOL) of pediatric patients and plasma glucose concentration regulation in children with type 1 diabetes (T1DM) in the Ningxia Hui autonomous region. METHODS: The study involved children with T1DM admitted to the General Hospital of Ningxia Medical University between October 2011 and October 2021. The children and their parents completed general information and quality of life (QOL) questionnaires...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38495953/bert-based-medical-chatbot-enhancing-healthcare-communication-through-natural-language-understanding
#34
JOURNAL ARTICLE
Arun Babu, Sekhar Babu Boddu
The advent of modern technologies like Artificial Intelligence(AI), Internet of Things(IoT) and Deep Learning(DL) has ushered in a transformative era in healthcare, offering innovative solutions towards personalized healthcare by enhancing the quality of various medical services. Our proposed methodology involves the development of a BERT-based medical chatbot, leveraging cutting-edge deep learning technology to significantly enhance healthcare communication and accessibility. The traditional challenges faced by medical chatbots, such as imprecise understanding of medical conversations, inaccurate responses to jargon, and the inability to offer personalized feedback, are addressed through the utilization of Bidirectional Encoder Representations from Transformers (BERT)...
March 2024: Explor Res Clin Soc Pharm
https://read.qxmd.com/read/38495910/workplace-trauma-and-professional-quality-of-life-in-clinical-and-forensic-psychiatry-the-critic-study
#35
JOURNAL ARTICLE
Anthony F T Bloemendaal, Astrid M Kamperman, Annette E Bonebakker, N Kool, M Olff, C L Mulder
BACKGROUND: Frontline staff in psychiatry need to perform at a very high professional level in order to ensure patient and community safety. At the same time they are exposed to high levels of stress and workplace trauma. This may have severe consequences for their professional quality of life. In addition, health care workers in general have higher incidence levels of childhood adversity than the general population. The CRITIC (CRITical Incidents and aggression in Caregivers) Study aims to improve increased understanding of the interaction between personal life history (childhood adversity and benevolence), individual capabilities, exposure to trauma and violence at work and Professional Quality of Life (ProQOL)...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38495864/biomedical-laboratory-scientists-and-technicians-in-digital-pathology-is-there-a-need-for-professional-development
#36
JOURNAL ARTICLE
Charlotte Lerbech Jensen, Lisbeth Koch Thomsen, Mette Zeuthen, Sys Johnsen, Rima El Jashi, Michael Friberg Bruun Nielsen, Line E Hemstra, Julie Smith
OBJECTIVE: Digital pathology (DP) is moving into Danish pathology departments at high pace. Conventionally, biomedical laboratory scientists (BLS) and technicians have prepared tissue sections for light microscopy, but workflow alterations are required for the new digital era with whole slide imaging (WSI); digitally assisted image analysis (DAIA) and artificial intelligence (AI). We aim to explore the role of BLS in DP and assess a potential need for professional development. METHODS: We investigated the roles of BLS in the new digital era through qualitative interviews at Danish Pathology Departments in 2019/2020 before DP implementation (supported by a questionnaire); and in 2022 after DP implementation...
2024: Digital Health
https://read.qxmd.com/read/38495863/machine-learning-methods-to-discriminate-posttraumatic-stress-disorder-a-protocol-of-systematic-review-and-meta-analysis
#37
JOURNAL ARTICLE
Jing Wang, Hui Ouyang, Runda Jiao, Haiyan Zhang, Suhui Cheng, Zhilei Shang, Yanpu Jia, Wenjie Yan, Lili Wu, Weizhi Liu
INTRODUCTION: Recent years have witnessed a persistent threat to public mental health, especially during and after the COVID-19 pandemic. Posttraumatic stress disorder (PTSD) has emerged as a pivotal concern amidst this backdrop. Concurrently, machine learning (ML) techniques have progressively applied in the realm of mental health. Therefore, our present undertaking seeks to provide a comprehensive assessment of studies employing ML methods that use diverse data modalities on the classification of people with PTSD...
2024: Digital Health
https://read.qxmd.com/read/38495860/application-of-standardized-management-and-effect-evaluation-of-chronic-obstructive-pulmonary-disease-patients-using-the-big-data-center-of-the-internet-of-things
#38
JOURNAL ARTICLE
Xiaoping Chen, Fei He, Yan Jiang, Xuezhen Chen, Yubing Yan
OBJECTIVE: Early detection, diagnosis, treatment and management of chronic obstructive pulmonary disease can lower morbidity and perhaps mortality. This study aimed to evaluate the effect of the application of standardized management against the background of the rapid development of the big data center of modern internet of things technology. METHODS: Participants ≥40 years of age with chronic obstructive pulmonary disease presenting at Xiamen Medical College Affiliated Haicang Hospital from October 2019 to October 2020 were selected as the observation patients based on the Internet of Things big data center for chronic obstructive pulmonary disease standardized management, and control patients from the community were selected for without down to the chronic obstructive pulmonary disease standardized management...
2024: Digital Health
https://read.qxmd.com/read/38495780/12-tips-for-developing-physician-education
#39
JOURNAL ARTICLE
Kelly McCoy, Lisa Fore-Arcand
The education of a physician is a life-long process. Healthcare is a dynamic field characterized by continuous advancements in medicine, evolving treatment options, changing regulations, care models, and technology. Physicians must keep up-to-date with new practices, procedures, medications, and diseases and fulfill the educational requirements to maintain their medical licensure. Continuing education for physicians serves the essential purpose of nurturing lifelong learning, ensuring that medical practices align with the latest standards, and ultimately enhancing the quality of patient care and outcomes...
2024: MedEdPublish (2016)
https://read.qxmd.com/read/38495735/role-of-interventional-bronchoscopy-and-chemotherapy-in-the-treatment-of-patients-with-small-cell-lung-cancer-a-case-report
#40
Haiyan Liu, Jun Zhao
Most of the small-cell lung cancer patients are of the central type of lung cancer. Small-cell lung cancer often intrudes into the atmospheric tract and large blood vessels, thus causing severe tracheobronchial stenosis and superior vena cava syndrome. In addition, patients with malignant tumors, especially those with respiratory failure and severe hypoxia, can be complicated with thromboembolic diseases. We reported a 65-year-old woman with severe stenosis of the trachea, and right main bronchus complicated with acute respiratory failure was treated with bronchoscopy and stent implantation to improve the patient's dyspnea, thus successfully receiving chemotherapy and timely treatment...
2024: SAGE Open Medical Case Reports
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