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lipidomic biomarkers

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https://www.readbyqxmd.com/read/29028617/a-plasma-lipidomics-strategy-reveals-perturbed-lipid-metabolic-pathways-and-potential-lipid-biomarkers-of-human-colorectal-cancer
#1
Sensen Shen, Li Yang, Linnan Li, Yu Bai, Chun Cai, Huwei Liu
To explore underlying molecular mechanisms and identify novel lipid biomarkers promising for colorectal cancer (CRC) diagnosis, a continuous-flow two dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry (2D LC-QToF/MS) method was employed to comprehensively measure lipid species in human plasma of CRC patients and healthy controls. With a total of 427 annotated lipid species, we identified 64 lipid species with corrected p value less than 0.05 and fold change more than 1.5. These significantly altered lipid species were mainly involved in glycerolipids and glycerophospholipids metabolism and sphingolipids metabolism...
October 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28987721/circulating-inflammation-resolving-lipid-mediators-rvd1-and-dha-are-decreased-in-patients-with-acutely-symptomatic-carotid-disease
#2
Hernan A Bazan, Yan Lu, Bokkyoo Jun, Zhide Fang, T Cooper Woods, Song Hong
BACKGROUND: Efficient biomarkers for early prediction and diagnosis of an acutely symptomatic carotid plaque rupture event are currently lacking, impairing the ability to diagnose and treat patients with an acute plaque rupture events in a timely fashion. Resolvins are endogenous inflammation-resolving lipid mediators that are induced by inflammatory insults. We hypothesized that resolvin and other lipid profiles in sera likely mark the process towards plaque rupture. METHODS: Circulating lipids associated with plaque rupture events were quantitatively profiled via targeted mediator-lipidomics using ultraperformance liquid chromatography tandem mass spectrometry in patients with acutely symptomatic and asymptomatic carotid disease...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28986283/effects-of-high-fat-diet-and-age-on-the-blood-lipidome-and-circulating-endocannabinoids-of-female-c57bl-6-mice
#3
Sumitra Pati, Saritha Krishna, Jung Hwa Lee, Matthew K Ross, Claire B de La Serre, Donald A Harn, John J Wagner, Nikolay M Filipov, Brian S Cummings
Alterations in lipid metabolism play a significant role in the pathogenesis of obesity-associated disorders, and dysregulation of the lipidome across multiple diseases has prompted research to identify novel lipids indicative of disease progression. To address the significant gap in knowledge regarding the effect of age and diet on the blood lipidome, we used shotgun lipidomics with electrospray ionization-mass spectrometry (ESI-MS). We analyzed blood lipid profiles of female C57BL/6 mice following high-fat diet (HFD) and low-fat diet (LFD) consumption for short (6weeks), long (22weeks), and prolonged (36weeks) periods...
October 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28971757/current-progress-of-lipid-analysis-in-metabolic-diseases-by-mass-spectrometry-methods
#4
Adriana Mika, Tomasz Sledzinski, Piotr Stepnowski
Obesity, insulin resistance, diabetes, and metabolic syndrome are associated with lipid alterations, and they affect the risk of long-term cardiovascular disease. Despite significant progress in medicine almost 400 million people are diabetic. Abdominal obesity is the reason for about 60% of heart attacks in western Europe. A reliable analytical instrument, not only to detect changes in the composition of lipids or their structures, but also the techniques or methods which will assist us to connect changes in a specific group of lipids with a specific disease and its progress, is constantly lacking...
October 3, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28956582/effect-of-the-dietary-intake-of-melatonin-and-hydroxytyrosol-rich-wines-by-healthy-female-volunteers-on-the-systemic-lipidomic-related-oxylipins
#5
Javier Marhuenda, Sonia Medina, Pedro Martínez-Hernández, Simon Arina, Pilar Zafrilla, Juana Mulero, Camille Oger, Jean-Marie Galano, Thierry Durand, Antonio Solana, Federico Ferreres, Juan José López-García, Angel Gil-Izquierdo
Oxylipins are lipid mediators involved in the physiopathology of all organs. Moreover, isoprostanes have been established as general and reliable in vivo oxidative stress biomarkers. Red wine has proved to exert several benefits through the maintenance of the oxidative balance of the organism. Antiradical scavenging capacity has been mainly attributed to polyphenols. However, melatonin and hydroxytyrosol should be taken into account as potent antiradical agents. The present research aimed to clarify the situation of enzymatic and oxidative injury and eicosanoid urinary excretion related to the intake of three kinds of red wines and their primary musts...
September 28, 2017: Food & Function
https://www.readbyqxmd.com/read/28955622/comparative-lipidomics-of-drug-sensitive-and-resistant-mycobacterium-tuberculosis-reveals-altered-lipid-imprints
#6
Rahul Pal, Saif Hameed, Parveen Kumar, Sarman Singh, Zeeshan Fatima
Lipids are most adaptable molecules that acclimatize to the development of multidrug resistance (MDR). The precise molecular mechanism of this acclimatization achieved in Mycobacterium tuberculosis (MTB) remains elusive. Although lipids of MTB have been characterized to some details, a comparable resource does not exist between drug sensitive (DS) and resistant (DR) strains of MTB. Here, by employing high-throughput mass spectrometry-based lipidomic approach, we attempted to analyze the differential lipidome profile of DS and DR MTB clinical isolates...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28949339/identification-of-a-plasma-signature-of-psychotic-disorder-in-children-and-adolescents-from-the-avon-longitudinal-study-of-parents-and-children-alspac-cohort
#7
A O'Gorman, T Suvitaival, L Ahonen, M Cannon, S Zammit, G Lewis, H M Roche, I Mattila, T Hyotylainen, M Oresic, L Brennan, D R Cotter
The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and lipidomic approaches in combination with multivariate statistical analysis were applied to identify plasma alterations in children (age 11) (38 cases vs 67 controls) and adolescents (age 18) (36 cases vs 117 controls) preceeding or coincident with the development of psychotic disorder (PD) at age 18 in the Avon Longitudinal Study of Parents and Children (ALSPAC)...
September 26, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28941595/lipidome-as-a-predictive-tool-in-progression-to-type-2-diabetes-in-finnish-men
#8
Tommi Suvitaival, Isabel Bondia-Pons, Laxman Yetukuri, Päivi Pöhö, John J Nolan, Tuulia Hyötyläinen, Johanna Kuusisto, Matej Orešič
BACKGROUND: There is a need for early markers to track and predict the development of type 2 diabetes mellitus (T2DM) from the state of normal glucose tolerance through prediabetes. In this study we tested whether the plasma molecular lipidome has biomarker potential to predicting the onset of T2DM. METHODS: We applied global lipidomic profiling on plasma samples from well-phenotyped men (107 cases, 216 controls) participating in the longitudinal METSIM study at baseline and at five-year follow-up...
September 20, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28935855/establishing-multiple-omics-baselines-for-three-southeast-asian-populations-in-the-singapore-integrative-omics-study
#9
Woei-Yuh Saw, Erwin Tantoso, Husna Begum, Lihan Zhou, Ruiyang Zou, Cheng He, Sze Ling Chan, Linda Wei-Lin Tan, Lai-Ping Wong, Wenting Xu, Don Kyin Nwe Moong, Yenly Lim, Bowen Li, Nisha Esakimuthu Pillai, Trevor A Peterson, Tomasz Bielawny, Peter J Meikle, Piyushkumar A Mundra, Wei-Yen Lim, Ma Luo, Kee-Seng Chia, Rick Twee-Hee Ong, Liam R Brunham, Chiea-Chuen Khor, Heng Phon Too, Richie Soong, Markus R Wenk, Peter Little, Yik-Ying Teo
The Singapore Integrative Omics Study provides valuable insights on establishing population reference measurement in 364 Chinese, Malay, and Indian individuals. These measurements include > 2.5 millions genetic variants, 21,649 transcripts expression, 282 lipid species quantification, and 284 clinical, lifestyle, and dietary variables. This concept paper introduces the depth of the data resource, and investigates the extent of ethnic variation at these omics and non-omics biomarkers. It is evident that there are specific biomarkers in each of these platforms to differentiate between the ethnicities, and intra-population analyses suggest that Chinese and Indians are the most biologically homogeneous and heterogeneous, respectively, of the three groups...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28874844/serum-monounsaturated-triacylglycerol-predicts-steatohepatitis-in-patients-with-non-alcoholic-fatty-liver-disease-and-chronic-hepatitis-b
#10
Rui-Xu Yang, Chun-Xiu Hu, Wan-Lu Sun, Qin Pan, Feng Shen, Zhen Yang, Qing Su, Guo-Wang Xu, Jian-Gao Fan
Chronic liver disease is associated with lipid metabolic disruption. We carried out a study to determine serum lipidomic features of patients with non-alcoholic fatty liver disease (NAFLD) and active chronic hepatitis B (CHB) and explored the biomarkers for non-alcoholic steatohepatitis (NASH). Serum lipidomic profiles of healthy controls (n = 23) and of biopsy-proven NAFLD (n = 42), CHB with NAFLD (n = 22) and without NAFLD (n = 17) were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871103/lipidomic-dysregulation-within-the-lung-parenchyma-following-whole-thorax-lung-irradiation-markers-of-injury-inflammation-and-fibrosis-detected-by-maldi-msi
#11
Claire L Carter, Jace W Jones, Ann M Farese, Thomas J MacVittie, Maureen A Kane
Radiation-induced lung injury (RILI) is a delayed effect of acute radiation exposure that can limit curative cancer treatment therapies and cause lethality following high-dose whole-thorax lung irradiation (WTLI). To date, the exact mechanisms of injury development following insult remain ill-defined and there are no FDA approved pharmaceutical agents or medical countermeasures. Traditionally, RILI development is considered as three phases, the clinically latent period, the intermediate acute pneumonitis phase and the later fibrotic stage...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870126/innovative-biomarkers-in-psychiatric-disorders-a-major-clinical-challenge-in-psychiatry
#12
Madia Lozupone, Davide Seripa, Eleonora Stella, Maddalena La Montagna, Vincenzo Solfrizzi, Nicola Quaranta, Federica Veneziani, Alberto Cester, Rodolfo Sardone, Caterina Bonfiglio, Gianluigi Giannelli, Paola Bisceglia, Roberto Bringiotti, Antonio Daniele, Antonio Greco, Antonello Bellomo, Giancarlo Logroscino, Francesco Panza
Currently, the diagnosis of psychiatric illnesses is based upon DSM-5 criteria. Although endophenotype-specificity for a particular disorder is discussed, the identification of objective biomarkers is ongoing for aiding diagnosis, prognosis, or clinical response to treatment. We need to improve the understanding of the biological abnormalities in psychiatric illnesses across conventional diagnostic boundaries. The present review investigates the innovative post-genomic knowledge used for psychiatric illness diagnostics and treatment response, with a particular focus on proteomics...
September 11, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28859259/mass-spectrometry-based-lipidomics
#13
Ting Hu, Jin-Lan Zhang
Lipids, which have core functions in energy storage, signalling and biofilm structures, play important roles in a variety of cellular processes because of the great diversity of their structural and physiochemical properties. Lipidomics is the large-scale profiling and quantification of biogenic lipid molecules, the comprehensive study of their pathways and the interpretation of their physiological significance based on analytical chemistry and statistical analysis. Lipidomics will not only provide insight into the physiological functions of lipid molecules but will also provide an approach to discovering important biomarkers for diagnosis or treatment of human diseases...
August 31, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28829206/new-perspectives-on-ckd-induced-dyslipidemia
#14
REVIEW
Marcelino Bermúdez-López, David Arroyo, Àngels Betriu, Luis Masana, Elvira Fernández, Jose M Valdivielso
Chronic kidney disease (CKD) is a world-wide health concern associated with a significantly higher cardiovascular morbidity and mortality. One of the principal cardiovascular risk factors is the lipid profile. CKD patients have a more frequent and progressive atheromatous disease that cannot be explained by the classical lipid parameters used in the daily clinical practice. Areas covered: The current review summarizes prevailing knowledge on the role of lipids in atheromathosis in CKD patients, including an overview of lipoprotein metabolism highlighting the CKD-induced alterations...
October 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28826666/paradoxical-coronary-artery-disease-in-humans-with-hyperalphalipoproteinemia-is-associated-with-distinct-differences-in-the-high-density-lipoprotein-phosphosphingolipidome
#15
William Hancock-Cerutti, Marie Lhomme, Carolane Dauteuille, Sora Lecocq, M John Chapman, Daniel J Rader, Anatol Kontush, Marina Cuchel
BACKGROUND: Plasma high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with risk of coronary artery disease (CAD) in epidemiologic studies. Despite this, the directionality of this relationship and the underlying biology behind it remain to be firmly established, especially at the extremes of HDL-C levels. OBJECTIVE: We investigated differences in the HDL phosphosphingolipidome in a rare population of subjects with premature CAD despite high HDL-C levels to gain insight into the association between the HDL lipidome and CAD disease status in this unusual phenotype...
September 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28821754/discovery-of-potential-biomarkers-in-human-melanoma-cells-with-different-metastatic-potential-by-metabolic-and-lipidomic-profiling
#16
Hye-Youn Kim, Hwanhui Lee, So-Hyun Kim, Hanyong Jin, Jeehyeon Bae, Hyung-Kyoon Choi
Malignant melanoma, characterized by its ability to metastasize to other organs, is responsible for 90% of skin cancer mortality. To investigate alterations in the cellular metabolome and lipidome related to melanoma metastasis, gas chromatography-mass spectrometry (GC-MS) and direct infusion-mass spectrometry (DI-MS)-based metabolic and lipidomic profiling were performed on extracts of normal human melanocyte (HEMn-LP), low metastatic melanoma (A375, G361), and highly metastatic melanoma (A2058, SK-MEL-28) cell lines...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821634/lipidomic-and-proteomic-analysis-of-exosomes-from-mouse-cortical-collecting-duct-cells
#17
Viet D Dang, Kishore Kumar Jella, Ragy R T Ragheb, Nancy D Denslow, Abdel A Alli
Exosomes are endosome-derived nanovesicles that are involved in cellular communication and signaling. Exosomes are produced by epithelial cells and are found in biologic fluids including blood and urine. The packaged material within exosomes includes proteins and lipids, but the molecular comparison within exosome subtypes is largely unknown. The purpose of this study was to investigate differences between exosomes derived from the apical plasma membrane and basolateral plasma membrane of polarized murine cortical collecting duct principal cells...
August 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28793282/increased-risk-of-atherosclerosis-in-patients-with-sarcoidosis
#18
Elena Bargagli, Elisabetta Rosi, Massimo Pistolesi, Federico Lavorini, Luca Voltolini, Paola Rottoli
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Recent studies demonstrated that its pathogenesis is related with enhanced oxidative stress (protein carbonylation and lipid peroxidation) and alterations in the circulating lipid profile. Alterations of lipid metabolism (including the reduction in high-density lipoprotein cholesterol levels and apolipoprotein A1 concentrations) induce plasma membrane, bronchial and lung capillary endothelial cell damage in sarcoidosis patients. Dyslipidemia is associated with increased oxidative stress, diminished overall antioxidative protection and increased risk for atherosclerosis...
August 10, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28789919/identification-of-long-and-very-long-chain-fatty-acids-plasmalogen-c16-0-and-phytanic-acid-as-new-lipid-biomarkers-in-tunisian-coronary-artery-disease-patients
#19
Samia Hadj Ahmed, Nadia Koubaa, Wafa Kharroubi, Amira Zarrouk, Amira Mnari, Fethi Batbout, Habib Gamra, Sonia Hammami, Gérard Lizard, Mohamed Hammami
Long and very long chain fatty acids (LCFAs and VLCFAs) may play an active role in coronary artery diseases (CAD) etiology. Our aim was to evaluate the associations between LCPUFAs (C20:4n-6; C20:5n-3 and C22:6n-3) and VLCSFAs (C22:0, C24:0; and C26:0), as well as markers of peroxisomal integrity evaluated by phytanic acid and plasmalogen-C16:0 (PL-C16:0) in addition to the markers of lipid peroxidation (malondialdehyde [MDA] and conjugated dienes [CD]) and inflammation (high sensitivity C-reactive protein [hs-CRP]) with vascular severity evaluated by Gensini score in order to determine their possible effects on CAD in Tunisian population...
August 5, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28783713/aging-and-sarcopenia-associate-with-specific-interactions-between-gut-microbes-serum-biomarkers-and-host-physiology-in-rats
#20
Jay Siddharth, Anirikh Chakrabarti, Alice Pannérec, Sonia Karaz, Delphine Morin-Rivron, Mojgan Masoodi, Jerome N Feige, Scott James Parkinson
The microbiome has been demonstrated to play an integral role in the maintenance of many aspects of health that are also associated with aging. In order to identify areas of potential exploration and intervention, we simultaneously characterized age-related alterations in gut microbiome, muscle physiology and serum proteomic and lipidomic profiles in aged rats to define an integrated signature of the aging phenotype. We demonstrate that aging skews the composition of the gut microbiome, in particular by altering the Sutterella to Barneseilla ratio, and alters the metabolic potential of intestinal bacteria...
July 17, 2017: Aging
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