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lipidomic biomarkers

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https://www.readbyqxmd.com/read/28106735/mass-spectrometry-based-metabolomic-and-lipidomic-analyses-of-the-effects-of-dietary-platycodon-grandiflorum-on-liver-and-serum-of-obese-mice-under-a-high-fat-diet
#1
Hye Min Park, Kab-Tae Park, Edmond Changkyun Park, Seung Ii Kim, Myung Sook Choi, Kwang-Hyeon Liu, Choong Hwan Lee
We aimed to identify metabolites involved in the anti-obesity effects of Platycodon grandiflorum (PG) in high-fat diet (HFD)-fed mice using mass spectrometry (MS)-based metabolomic techniques. C57BL/6J mice were divided into four groups: normal diet (ND)-fed mice, HFD-fed mice, HFD with 1% PG extract-fed mice (HPGL), and HFD with 5% PG extract-fed mice (HPGH). After 8 weeks, the HFD group gained more weight than the ND group, while dietary 5% PG extract attenuated this change. The partial least squares discriminant analysis (PLS-DA) score plots showed a clear distinction between experimental groups in serum and liver markers...
January 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28074328/lipidpioneer-a-comprehensive-user-generated-exact-mass-template-for-lipidomics
#2
Candice Z Ulmer, Jeremy P Koelmel, Jared M Ragland, Timothy J Garrett, John A Bowden
Lipidomics, the comprehensive measurement of lipid species in a biological system, has promising potential in biomarker discovery and disease etiology elucidation. Advances in chromatographic separation, mass spectrometric techniques, and novel substrate applications continue to expand the number of lipid species observed. The total number and type of lipid species detected in a given sample are generally indicative of the sample matrix examined (e.g., serum, plasma, cells, bacteria, tissue, etc.). Current exact mass lipid libraries are static and represent the most commonly analyzed matrices...
January 10, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28071669/use-of-fibonacci-numbers-in-lipidomics-enumerating-various-classes-of-fatty-acids
#3
Stefan Schuster, Maximilian Fichtner, Severin Sasso
In lipid biochemistry, a fundamental question is how the potential number of fatty acids increases with their chain length. Here, we show that it grows according to the famous Fibonacci numbers when cis/trans isomerism is neglected. Since the ratio of two consecutive Fibonacci numbers tends to the Golden section, 1.618, organisms can increase fatty acid variability approximately by that factor per carbon atom invested. Moreover, we show that, under consideration of cis/trans isomerism and/or of modification by hydroxy and/or oxo groups, diversity can be described by generalized Fibonacci numbers (e...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28040324/metabolomics-and-lipidomics-analyses-by-1-h-nuclear-magnetic-resonance-of-schizophrenia-patient-serum-reveal-potential-peripheral-biomarkers-for-diagnosis
#4
Ljubica Tasic, João G M Pontes, Michelle S Carvalho, Guilherme Cruz, Carolines Dal Mas, Sumit Sethi, Mariana Pedrini, Lucas B Rizzo, Maiara Zeni-Graiff, Elson Asevedo, Acioly L T Lacerda, Rodrigo A Bressan, Ronei Jesus Poppi, Elisa Brietzke, Mirian A F Hayashi
Using (1)H NMR-based metabolomics in association to chemometrics analysis, we analyzed here the metabolic differences between schizophrenia patients (SCZ) compared to healthy controls (HCs). HCs and SCZ patients underwent clinical interview using the Structured Clinical Interview for DSM Disorders (SCID). SCZ patients were further assessed by Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale, Global Assessment of Functioning Scale (GAF), and Clinical Global Impressions Scale (CGI). Using the principal component analysis (PCA) and supervised partial least-squares discriminate analysis (PLS-DA) in obtained NMR data, a clear group separation between HCs and SCZ patients was achieved...
December 28, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/28039059/recent-advances-in-lipidomics-analytical-and-clinical-perspectives
#5
REVIEW
Sumit Sethi, Elisa Brietzke
Lipidomics or lipid-profiling is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. The extent of information in the genomic and proteomic fields is greater than that in the lipidomics field, because of the complex nature of lipids and the limitations of tools for analysis. Modern technological advances in mass spectrometry and chromatography have greatly improved the developments and applications of metabolic profiling of diverse lipids in complex biological samples...
December 27, 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28031971/bluepen-biomarkers-llc-integrated-biomarker-solutions
#6
EDITORIAL
Ian A Blair, Clementina Mesaros, Patrick Lilley, Matthew Nunez
BluePen Biomarkers provides a unique comprehensive multi-omics biomarker discovery and validation platform. We can quantify, integrate and analyze genomics, proteomics, metabolomics and lipidomics biomarkers, alongside clinical data, demographics and other phenotypic data. A unique bio-inspired signal processing analytic approach is used that has the proven ability to identify biomarkers in a wide variety of diseases. The resulting biomarkers can be used for diagnosis, prognosis, mechanistic studies and predicting treatment response, in contexts from core research through clinical trials...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28025506/fatty-acids-in-membranes-as-homeostatic-metabolic-and-nutritional-biomarkers-recent-advancements-in-analytics-and-diagnostics
#7
REVIEW
Carla Ferreri, Annalisa Masi, Anna Sansone, Giorgia Giacometti, Anna Vita Larocca, Georgia Menounou, Roberta Scanferlato, Silvia Tortorella, Domenico Rota, Marco Conti, Simone Deplano, Maria Louka, Anna Rosaria Maranini, Arianna Salati, Valentina Sunda, Chryssostomos Chatgilialoglu
Fatty acids, as structural components of membranes and inflammation/anti-inflammatory mediators, have well-known protective and regulatory effects. They are studied as biomarkers of pathological conditions, as well as saturated and unsaturated hydrophobic moieties in membrane phospholipids that contribute to homeostasis and physiological functions. Lifestyle, nutrition, metabolism and stress-with an excess of radical and oxidative processes-cause fatty acid changes that are examined in the human body using blood lipids...
December 22, 2016: Diagnostics
https://www.readbyqxmd.com/read/28004822/mass-spectrometry-imaging-of-biomarker-lipids-for-phagocytosis-and-signalling-during-focal-cerebral-ischaemia
#8
Mette M B Nielsen, Kate L Lambertsen, Bettina H Clausen, Morten Meyer, Dhaka R Bhandari, Søren T Larsen, Steen S Poulsen, Bernhard Spengler, Christian Janfelt, Harald S Hansen
Focal cerebral ischaemia has an initial phase of inflammation and tissue injury followed by a later phase of resolution and repair. Mass spectrometry imaging (desorption electrospray ionization and matrix assisted laser desorption ionization) was applied on brain sections from mice 2 h, 24 h, 5d, 7d, and 20d after permanent focal cerebral ischaemia. Within 24 h, N-acyl-phosphatidylethanolamines, lysophosphatidylcholine, and ceramide accumulated, while sphingomyelin disappeared. At the later resolution stages, bis(monoacylglycero)phosphate (BMP(22:6/22:6)), 2-arachidonoyl-glycerol, ceramide-phosphate, sphingosine-1-phosphate, lysophosphatidylserine, and cholesteryl ester appeared...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28002106/the-application-of-lipidomics-to-biomarker-research-and-pathomechanisms-in-alzheimer-s-disease
#9
Matthew W Wong, Nady Braidy, Anne Poljak, Perminder S Sachdev
PURPOSE OF REVIEW: Alzheimer's disease is the most common cause of dementia. There are still no disease modifying treatments that can cure or slow disease progression. Recently, Alzheimer's disease researchers have attempted to improve early detection and diagnostic criteria for Alzheimer's disease, with the rationale that treatment of disease, or even prevention, may be more successful during the early preclinical stages of Alzheimer's disease when neurodegenerative damage is not as widespread...
December 20, 2016: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/27984134/long-title-translational-potential-of-long-term-decreases-in-mitochondrial-lipids-in-a-mouse-model-of-gulf-war-illness
#10
Laila Abdullah, James E Evans, Utsav Joshi, Gogce Crynen, John Reed, Benoit Mouzon, Stephan Baumann, Hannah Montague, Zuchra Zakirova, Tanja Emmerich, Corbin Bachmeier, Nancy Klimas, Kimberly Sullivan, Michael Mullan, Ghania Ait-Ghezala, Fiona Crawford
Gulf War Illness (GWI) affects 25% of veterans from the 1990-1991 Gulf War (GW) and is accompanied by damage to the brain regions involved in memory processing. After twenty-five years, the chronic pathobiology of GWI is still unexplained. To address this problem, we examined the long-term consequences of GW exposures in an established GWI mouse model to identify biological processes that are relevant to the chronic symptoms of GWI. Three-month old male C57BL6 mice were exposed for 10days to GW agents (pyridostigmine bromide and permethrin)...
October 29, 2016: Toxicology
https://www.readbyqxmd.com/read/27973561/cross-classification-of-human-urinary-lipidome-by-sex-age-and-body-mass-index
#11
Kazuo Okemoto, Keiko Maekawa, Yoko Tajima, Masahiro Tohkin, Yoshiro Saito
Technological advancements in past decades have led to the development of integrative analytical approaches to lipidomics, such as liquid chromatography-mass spectrometry (LC/MS), and information about biogenic lipids is rapidly accumulating. Although several cohort-based studies have been conducted on the composition of urinary lipidome, the data on urinary lipids cross-classified by sex, age, and body mass index (BMI) are insufficient to screen for various abnormalities. To promote the development of urinary lipid metabolome-based diagnostic assay, we analyzed 60 urine samples from healthy white adults (young (c...
2016: PloS One
https://www.readbyqxmd.com/read/27931520/translational-potential-of-long-term-decreases-in-mitochondrial-lipids-in-a-mouse-model-of-gulf-war-illness
#12
Laila Abdullah, James E Evans, Utsav Joshi, Gogce Crynen, Jon Reed, Benoit Mouzon, Stephan Baumann, Hannah Montague, Zuchra Zakirova, Tanja Emmerich, Corbin Bachmeier, Nancy Klimas, Kimberly Sullivan, Michael Mullan, Ghania Ait-Ghezala, Fiona Crawford
Gulf War Illness (GWI) affects 25% of veterans from the 1990-1991 Gulf War (GW) and is accompanied by damage to the brain regions involved in memory processing. After twenty-five years, the chronic pathobiology of GWI is still unexplained. To address this problem, we examined the long-term consequences of GW exposures in an established GWI mouse model to identify biological processes that are relevant to the chronic symptoms of GWI. Three-month old male C57BL6 mice were exposed for 10days to GW agents (pyridostigmine bromide and permethrin)...
November 30, 2016: Toxicology
https://www.readbyqxmd.com/read/27916803/advances-in-lipidomics-for-cancer-biomarkers-discovery
#13
REVIEW
Francesca Perrotti, Consuelo Rosa, Ilaria Cicalini, Paolo Sacchetta, Piero Del Boccio, Domenico Genovesi, Damiana Pieragostino
Lipids play critical functions in cellular survival, proliferation, interaction and death, since they are involved in chemical-energy storage, cellular signaling, cell membranes, and cell-cell interactions. These cellular processes are strongly related to carcinogenesis pathways, particularly to transformation, progression, and metastasis, suggesting the bioactive lipids are mediators of a number of oncogenic processes. The current review gives a synopsis of a lipidomic approach in tumor characterization; we provide an overview on potential lipid biomarkers in the oncology field and on the principal lipidomic methodologies applied...
November 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27914242/molecular-lipid-species-in-urinary-exosomes-as-potential-prostate-cancer-biomarkers
#14
Tore Skotland, Kim Ekroos, Dimple Kauhanen, Helena Simolin, Therese Seierstad, Viktor Berge, Kirsten Sandvig, Alicia Llorente
BACKGROUND: Exosomes have recently appeared as a novel source of noninvasive cancer biomarkers, since these nanovesicles contain molecules from cancer cells and can be detected in biofluids. We have here investigated the potential use of lipids in urinary exosomes as prostate cancer biomarkers. METHODS: A high-throughput mass spectrometry quantitative lipidomic analysis was performed to reveal the lipid composition of urinary exosomes in prostate cancer patients and healthy controls...
January 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/27906700/update-on-lipid-species-and-paediatric-nonalcoholic-fatty-liver-disease
#15
Jake P Mann, Ariel E Feldstein, Valerio Nobili
PURPOSE OF REVIEW: To describe the recent advances in our understanding of fatty acids and lipids in paediatric nonalcoholic fatty liver disease (NAFLD) and their future implications. RECENT FINDINGS: Data have been accumulated to suggest that ceramides are the main drivers of hepatic insulin resistance in NAFLD, and inhibition of ceramide synthesis improves histology in mice.Saturated fatty acids formed by de novo lipogenesis generate increased lipotoxicity compared with dietary-derived saturated fatty acids...
November 30, 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27871881/targeting-brain-and-peripheral-plasticity-of-the-lipidome-in-acute-kainic-acid-induced-epileptic-seizures-in-mice-via-quantitative-mass-spectrometry
#16
Raissa Lerner, Julia Post, Sebastian Loch, Beat Lutz, Laura Bindila
Epilepsy is a highly common chronic neurological disorder, manifested in many different types, affecting ~1% of the worldwide human population. The molecular mechanisms of epileptogenesis have not yet been clarified, and pharmacoresistance exhibited by 30-40% of epilepsy patients remains a major obstacle in medical care. Growing evidence indicates a role of lipid signalling pathways in epileptogenesis, thus lipid signals emerge as potential biomarkers for the onset and evolving course of the epileptic disorder, as well as potential therapeutic agents and targets...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27836780/oxidative-stress-leads-to-reduction-of-plasmalogen-serving-as-a-novel-biomarker-for-systemic-lupus-erythematosus
#17
Changfeng Hu, Jia Zhou, Shasha Yang, Haichang Li, Chunyan Wang, Xiaoling Fang, Yongsheng Fan, Jida Zhang, Xianlin Han, Chengping Wen
Oxidative stress is elevated in systemic lupus erythematosus (SLE) patients, and associated extensively with SLE pathogenesis. However, no common indicators of oxidative stress are yet in routine clinical use because of their instability, nonspecificity, and non-representation of all SLE symptoms. Moreover, the method for reproducible analysis of reactive oxygen species is still lacking. Lipids and their metabolites are essential components of biological systems, many of which serve as molecular targets of oxidative stress and play crucial roles in signaling, inflammation, and immune responses...
December 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27830727/exploration-of-the-sphingolipid-metabolite-sphingosine-1-phosphate-and-sphingosine-as-novel-biomarkers-for-aspirin-exacerbated-respiratory-disease
#18
Hoang Kim Tu Trinh, Su-Chin Kim, Kumsun Cho, Su-Jung Kim, Ga-Young Ban, Hyun-Ju Yoo, Joo-Youn Cho, Hae-Sim Park, Seung-Hyun Kim
Sphingolipid (SL) metabolites have been suggested to be important inflammatory mediators in airway inflammation and asthma. However, little is known about SL metabolites in aspirin-exacerbated respiratory disease (AERD). We aimed to explore the potential AERD biomarkers by conducting lipidomics targeting SL metabolites. The levels of SL metabolites in serum and urine samples from 45 AERD patients and 45 aspirin-tolerant asthma (ATA) patients were quantified through mass spectrometry. During the lysine-aspirin bronchoprovocation test (ASA-BPT), the levels of serum sphingomyelin (SM) were significantly decreased in AERD (P < 0...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27827927/lipidomics-reshaping-the-analysis-and-perception-of-type-2-diabetes
#19
REVIEW
Daniel F Markgraf, Hadi Al-Hasani, Stefan Lehr
As a consequence of a sedentary lifestyle as well as changed nutritional behavior, today's societies are challenged by the rapid propagation of metabolic disorders. A common feature of diseases, such as obesity and type 2 diabetes (T2D), is the dysregulation of lipid metabolism. Our understanding of the mechanisms underlying these diseases is hampered by the complexity of lipid metabolic pathways on a cellular level. Furthermore, overall lipid homeostasis in higher eukaryotic organisms needs to be maintained by a highly regulated interplay between tissues, such as adipose tissue, liver and muscle...
November 4, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27805426/the-metabolomics-and-lipidomics-window-into-thyroid-cancer-research
#20
R Farrokhi Yekta, M Rezaie Tavirani, A Arefi Oskouie, M R Mohajeri-Tehrani, A R Soroush
CONTEXT: Thyroid carcinoma is the most common endocrine system malignancy with a fast rising incidence in the last decade for unknown reasons. Fine needle aspiration (FNA) biopsy, the gold standard in thyroid cancer (TC) screening has still its own challenges and in some cases needs a proceeding surgery. OBJECTIVE: This review highlights the role of the two most recent "omics" approaches, "metabolomics" and "lipidomics", in the field of TC research. METHODS: All the previous studies have been extracted from the literature and major concepts were detailed in the field of TC metabolomics and lipidomics...
November 15, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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