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https://www.readbyqxmd.com/read/29655461/metabolomics-and-lipidomics-of-ischemic-stroke
#1
Anthony Au
Ischemic stroke is a sudden loss of brain function due to the reduction of blood flow. Brain tissues cease to function with subsequent activation of the ischemic cascade. Metabolomics and lipidomics are modern disciplines that characterize the metabolites and lipid components of a biological system, respectively. Because the pathogenesis of ischemic stroke is heterogeneous and multifactorial, it is crucial to establish comprehensive metabolomic and lipidomic approaches to elucidate these alterations in this disease...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29627572/lipidomic-profiling-of-plasma-samples-from-patients-with-mitochondrial-disease
#2
Caixia Ren, Jia Liu, Juntuo Zhou, Hui Liang, Yizhang Zhu, Qingqing Wang, Yinglin Leng, Zhe Zhang, Yun Yuan, Zhaoxia Wang, Yuxin Yin
Mitochondrial disease (MD) is a rare mitochondrial respiratory chain disorder with a high mortality and extremely challenging to treat. Although genomic, transcriptomic, and proteomic analyses have been performed to investigate the pathogenesis of MD, the role of metabolomics in MD, particularly of lipidomics remains unclear. This study was undertaken to identify potential lipid biomarkers of MD. An untargeted lipidomic approach was used to compare the plasma lipid metabolites in 20 MD patients and 20 controls through Liquid Chromatography coupled to Mass Spectrometry...
April 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29624380/rapid-in-situ-profiling-of-lipid-c-c-location-isomers-in-tissue-using-ambient-mass-spectrometry-with-photochemical-reactions
#3
Fei Tang, Chengan Guo, Xiaoxiao Ma, Jian Zhang, Yuan Su, Ran Tian, Riyi Shi, Yu Xia, Xiaohao Wang, Zheng Ouyang
Rapid and in situ profiling of lipids using ambient mass spectrometry (AMS) techniques has great potential for clinical diagnosis, biological studies and biomarker discovery. In this study, the online photochemical reaction involving carbon-carbon double bonds, was coupled with a surface sampling technique to develop a direct tissue analysis method with specificity to lipid C=C isomers. This method enabled the in situ analysis of lipids from the surface of various tissues or tissue sections, which allowed the structural characterization of lipid isomers within 2 minutes...
April 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29623000/lipidomic-profiling-of-plasma-and-erythrocytes-from-septic-patients-reveals-potential-biomarker-candidates
#4
Giovana Colozza Mecatti, Marcia Cristina Fernandes Messias, Rafaela Maria Sant'Anna Paiola, Célio Fernando Figueiredo Angolini, Ildenize Barbosa da Silva Cunha, Marcos Nogueira Eberlin, Patricia de Oliveira Carvalho
Background: Sepsis remains the primary cause of death from infection, despite advances in modern medicine. The identification of reliable diagnostic biomarkers for the early detection of this disease is critical and may reduce the mortality rate as it could allow early treatment. The purpose of this study was to describe the changes in the plasma and red cells blood lipidome profiling of patients diagnosed with sepsis and septic shock with the aim to identify potentially useful metabolic markers...
2018: Biomarker Insights
https://www.readbyqxmd.com/read/29605789/the-role-of-the-lipidome-in-obesity-mediated-colon-cancer-risk
#5
REVIEW
Raghav Jain, C Austin Pickens, Jenifer I Fenton
Obesity is a state of chronic inflammation influenced by lipids such as fatty acids and their secondary oxygenated metabolites deemed oxylipids. Many such lipid mediators serve as potent signaling molecules of inflammation, which can further alter lipid metabolism and lead to carcinogenesis. For example, sphingosine-1-phosphate activates cyclooxygenase-2 in endothelial cells resulting in the conversion of arachidonic acid (AA) to prostaglandin E2 (PGE2 ). PGE2 promotes colon cancer cell growth. In contrast, the less studied path of AA oxygenation via cytochrome p450 enzymes produces epoxyeicosatetraenoic acids (EETs), whose anti-inflammatory properties cause shrinking of enlarged adipocytes, a characteristic of obesity, through the liberation of fatty acids...
March 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29602396/lipidomics-and-biomarker-discovery-in-kidney-disease
#6
REVIEW
Farsad Afshinnia, Thekkelnaycke M Rajendiran, Stefanie Wernisch, Tanu Soni, Adil Jadoon, Alla Karnovsky, George Michailidis, Subramaniam Pennathur
Technological advances in mass spectrometry-based lipidomic platforms have provided the opportunity for comprehensive profiling of lipids in biological samples and shown alterations in the lipidome that occur in metabolic disorders. A lipidomic approach serves as a powerful tool for biomarker discovery and gaining insight to molecular mechanisms of disease, especially when integrated with other -omics platforms (ie, transcriptomics, proteomics, and metabolomics) in the context of systems biology. In this review, we describe the workflow commonly applied to the conduct of lipidomic studies including important aspects of study design, sample preparation, biomarker identification and quantification, and data processing and analysis, as well as crucial considerations in clinical applications...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29596837/lipidomics-biomarker-studies-errors-limitations-and-the-future
#7
Paul L Wood, John E Cebak
Lipidomics is an ever-expanding subfield of metabolomics that surveys 3000 to 5000 individual lipids across more than 56 lipid subclasses, including lipid peroxidation products. Unfortunately, there exists a large number of publications with poor quality data obtained with unit mass resolution leading to many lipid misidentifications. This is further complicated by poor scientific oversight with regard to recognition of isobar issues, sample collection, and sample storage issues that inexplicably requires more detailed attention...
March 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29573799/metabotypes-with-elevated-protein-and-lipid-catabolism-and-inflammation-precede-clinical-mastitis-in-prepartal-transition-dairy-cows
#8
F Zandkarimi, J Vanegas, X Fern, C S Maier, G Bobe
Clinical mastitis (CM), the most prevalent and costly disease in dairy cows, is diagnosed most commonly shortly after calving. Current indicators do not satisfactorily predict CM. This study aimed to develop a robust and comprehensive mass spectrometry-based metabolomic and lipidomic workflow using untargeted ultra-performance liquid chromatography high-resolution mass spectrometry for predictive biomarker detection. Using a nested case-control design, we measured weekly during the prepartal transition period differences in serum metabolites, lipids, inflammation markers, and minerals between clinically healthy Holstein dairy cows diagnosed with mastitis postcalving (CMP; n = 8; CM diagnosis d 1 = 3 cows, d 2 = 2 cows, d 4 = 1 cow; d 25 = 1 cow, and d 43 = 1 cow that had subclinical mastitis since d 3) or not (control; n = 9)...
March 21, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29568353/reprogrammed-lipid-metabolism-in-bladder-cancer-with-cisplatin-resistance
#9
Min Young Lee, Austin Yeon, Muhammad Shahid, Eunho Cho, Vikram Sairam, Robert Figlin, Khae-Hwan Kim, Jayoung Kim
Due to its tendency to recur and acquire chemoresistance quickly, bladder cancer (BC) remains to be an elusive and difficult disease. Patients with recurrent and chemoresistant BC have an extremely poor prognosis. One possible approach that may provide insightful and valuable information regarding resistance mechanisms is looking into the lipid metabolism of BC cells. Metabolism of lipids is essential for cancer cells and is associated with the regulation of a variety of key cellular processes and functions...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29561322/hdls-and-the-pathogenesis-of-atherosclerosis
#10
Adel Schwertani, Hong Y Choi, Jacques Genest
PURPOSE OF REVIEW: Plasma levels of HDL cholesterol are a biomarker of cardiovascular health but not a therapeutic target, as demonstrated by the failure of pharmacological modulation of HDL cholesterol to prevent or treat atherosclerotic cardiovascular disease. In health, HDL particles exert pleiotropic effects against atherosclerosis, including cholesterol removal from foam cells, vasodilatory effects through vascular endothelial cell nitric oxide production, decreased vascular inflammation and oxidative damage, endothelial cell proliferation and antiapoptotic effects...
March 19, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29557415/what-s-in-metabolomics-for-alcoholic-liver-disease
#11
Alina M Suciu, Dana A Crisan, Bogdan D Procopet, Corina I Radu, Carmen Socaciu, Marcel V Tantau, Horia O Stefanescu, Mircea Grigorescu
BACKGROUND AND AIMS: Current management of alcoholic liver disease (ALD), especially for alcoholic hepatitis (AH) is still driven by liver biopsy. Therefore, the identification of novel and accurate noninvasive biomarkers for the diagnosis and assessment of severity is important. Metabolomics, because it unravels changes closest to the phenotype, may represent the key for novel biomarkers. The aim of this study was to identify and characterize potential metabolomic biomarkers for diagnosis, staging and severity assessment of ALD...
March 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/29541056/lipidomics-analysis-of-behavioral-variant-frontotemporal-dementia-a-scope-for-biomarker-development
#12
Woojin Scott Kim, Eve Jary, Russell Pickford, Ying He, Rebekah M Ahmed, Olivier Piguet, John R Hodges, Glenda M Halliday
Behavioral variant frontotemporal dementia (bvFTD) is the most prevalent form of FTD syndromes. bvFTD is characterized clinically by changes in behavior and cognition and pathologically by focal brain atrophy and concomitant loss of lipids. bvFTD is further characterized by eating abnormalities that result in dyslipidemia. Although dyslipidemia is apparent in bvFTD, very little is known about global lipid changes in bvFTD and lipid dysregulation underlying bvFTD. Here, we undertook a comprehensive lipidomics analysis of blood plasma from patients with bvFTD, patients with Alzheimer's disease (AD) and controls, using liquid chromatography-tandem mass spectrometry, with the aim of understanding lipid dysregulation in bvFTD...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29530934/lipidomic-profiling-links-the-fanconi-anemia-pathway-to-glycosphingolipid-metabolism-in-head-and-neck-cancer-cells
#13
Xueheng Zhao, Marion G Brusadelli, Sharon L Sauter, Melinda Butsch Kovacic, Wujuan Zhang, Lindsey E Romick-Rosendale, Paul F Lambert, Kenneth D Setchell, Susanne I Wells
PURPOSE: Mutations in Fanconi anemia (FA) genes are common in sporadic squamous cell carcinoma of the head and neck (HNSCC) and we have previously demonstrated that FA pathway depletion in HNSCC cell lines stimulates invasion. The goal of our studies was to use a systems approach in order to define FA pathway-dependent lipid metabolism, and to extract lipid-based signatures and effectors of invasion in FA-deficient cells. EXPERIMENTAL DESIGN: We subjected FA-isogenic HNSCC keratinocyte cell lines to untargeted and targeted lipidomics analyses to discover novel biomarkers and candidate therapeutic targets in FA-deficient cells...
March 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29520382/unmasking-molecular-profiles-of-bladder-cancer
#14
REVIEW
Xuan-Mei Piao, Young Joon Byun, Wun-Jae Kim, Jayoung Kim
Precision medicine is designed to tailor treatments for individual patients by factoring in each person's specific biology and mechanism of disease. This paradigm shifted from a "one size fits all" approach to "personalized and precision care" requires multiple layers of molecular profiling of biomarkers for accurate diagnosis and prediction of treatment responses. Intensive studies are also being performed to understand the complex and dynamic molecular profiles of bladder cancer. These efforts involve looking bladder cancer mechanism at the multiple levels of the genome, epigenome, transcriptome, proteome, lipidome, metabolome etc...
March 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29492952/discrimination-of-papillary-thyroid-cancer-from-non-cancerous-thyroid-tissue-based-on-lipid-profiling-by-mass-spectrometry-imaging
#15
Anna Wojakowska, Laura M Cole, Mykola Chekan, Katarzyna Bednarczyk, Magdalena Maksymiak, Małgorzata Oczko-Wojciechowska, Barbara Jarząb, Malcolm R Clench, Joanna Polańska, Monika Pietrowska, Piotr Widlak
INTRODUCTION: The distinction of papillary thyroid carcinomas from benign thyroid lesions has important implication for clinical man-agement. Classification based on histopathological features can be supported by molecular biomarkers, including lipidomic signatures, identified with the use of high-throughput mass spectrometry techniques. Formalin fixation is a standard procedure for stabilization and preservation of tissue samples, therefore this type of samples constitute highly valuable source of clinical material for retrospective molecular studies...
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29461553/current-state-of-bioanalytical-chromatography-in-clinical-analysis
#16
REVIEW
H Kočová Vlčková, V Pilařová, P Svobodová, J Plíšek, F Švec, L Nováková
Chromatographic methods have become popular in clinical analysis in both routine and research laboratories. The purpose of this review article is to provide an overview of the current state of chromatographic methods, i.e., high-performance liquid chromatography (HPLC), gas chromatography (GC), and supercritical fluid chromatography (SFC), in clinical analysis. The aspects related to method sensitivity, selectivity, analysis time, and throughput have been discussed in detail. Adequate solutions to improve these features have also been presented...
February 20, 2018: Analyst
https://www.readbyqxmd.com/read/29454180/tryptophan-kynurenine-and-lipid-related-metabolites-as-blood-biomarkers-for-first-episode-drug-na%C3%A3-ve-patients-with-major-depressive-disorder-an-exploratory-pilot-case-control-study
#17
Nobuki Kuwano, Takahiro A Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenob Kanba
BACKGROUND: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naïve MDD, which are particularly important for early intervention in depression. METHODS: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naïve MDD patients, based on metabolome/lipidome analysis...
April 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29451398/examining-heat-treatment-for-stabilization-of-the-lipidome
#18
Jeremy P Koelmel, Christina M Jones, Candice Z Ulmer, Timothy J Garrett, Richard A Yost, Tracey B Schock, John A Bowden
AIM: To confidently determine lipid-based biomarkers, it is important to minimize variation introduced during preanalytical steps. We evaluated reducing variation associated with lipid measurements in invertebrate sentinel species using a state-of-the-art heat treatment technique. MATERIALS AND METHODS: Earthworms (Eisenia fetida), house crickets (Acheta domestica) and ghost shrimp (Palaemonetes paludosus) were euthanized either by flash freezing or heat treatment...
February 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29449691/enhanced-release-of-acid-sphingomyelinase-enriched-exosomes-generates-a-lipidomics-signature-in-csf-of-multiple-sclerosis-patients
#19
Damiana Pieragostino, Ilaria Cicalini, Paola Lanuti, Eva Ercolino, Maria di Ioia, Mirco Zucchelli, Romina Zappacosta, Sebastiano Miscia, Marco Marchisio, Paolo Sacchetta, Marco Onofrj, Piero Del Boccio
Multiple Sclerosis (MuS) is a complex multifactorial neuropathology, resulting in heterogeneous clinical presentation. A very active MuS research field concerns the discovery of biomarkers helpful to make an early and definite diagnosis. The sphingomyelin pathway has emerged as a molecular mechanism involved in MuS, since high levels of ceramides in cerebrospinal fluid (CSF) were related to axonal damage and neuronal dysfunction. Ceramides are the hydrolysis products of sphingomyelins through a reaction catalyzed by a family of enzymes named sphingomyelinases, which were recently related to myelin repair in MuS...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29435121/lipidomics-reveals-altered-biosynthetic-pathways-of-glycerophospholipids-and-cell-signaling-as-biomarkers-of-the-polycystic-ovary-syndrome
#20
Mariona Jové, Irene Pradas, Alba Naudí, Susana Rovira-Llopis, Celia Bañuls, Milagros Rocha, Manuel Portero-Otin, Antonio Hernández-Mijares, Victor M Victor, Reinald Pamplona
Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors such as dyslipemia, obesity, altered glucose/insulin metabolism, cardiovascular disease, or cancer. Results: Multivariate statistics revealed a specific lipidomic signature for PCOS patients without associated pathologies. This signature implies changes, mainly by down-regulation, in glycerolipid, glycerophospholipid and sphingolipid metabolism suggesting an altered biosynthetic pathway of glycerophospholipids and cell signaling as second messengers in women with PCOS...
January 12, 2018: Oncotarget
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