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cancer and soybean oil

Jingyi Hong, Yanhong Li, Yao Xiao, Yijing Li, Yifei Guo, Haixue Kuang, Xiangtao Wang
Annonaceous acetogenins (ACGs) have exhibited antitumor activity against various cancers. However, these substances' poor solubility has limited clinical applications. In this study, hydroxypropyl-beta-cyclodextrin (HP-β-CD) and soybean lecithin (SPC) were self-assembled into an amphiphilic complex. ACGs nanosuspensions (ACGs-NSps) were prepared with a mean particle size of 144.4nm, a zeta potential of -22.9mV and a high drug payload of 46.17% using this complex as stabilizer. The ACGs-NSps demonstrated sustained release in vitro and good stability in plasma as well as simulated gastrointestinal fluid, and met the demand of both intravenous injection and oral administration...
September 1, 2016: Colloids and Surfaces. B, Biointerfaces
D Pemberthy, A Quintero, M G Martrat, J Parera, M Ábalos, E Abad, A L Villa
Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) are commonly known as dioxins and are the most toxic members of persistent organic pollutants (POPs) because present a variety of health effects especially as promoting agent of growing and transformation of cancer cells. They are bio-accumulate in humans primarily via the diet, specifically by ingestion of foods that have high lipid content which are generally associated with foods of animal origin such as oils and fats and with fishery and dairy products...
October 15, 2016: Science of the Total Environment
Shigehiko Takegami, Keisuke Kitamura, Mayuko Ohsugi, Atsuko Konishi, Tatsuya Kitade
To design a useful lipid drug carrier having a high encapsulation efficiency (EE%) for the antiprostate cancer drugs flutamide (FT) and nilutamide (NT), a lipid nano-emulsion (LNE) was prepared with soybean oil (SO), phosphatidylcholine (PC), and sodium palmitate, and the partition coefficients (K ps) of the drugs for the LNE were determined by (19)F nuclear magnetic resonance (NMR) spectrometry. The (19)F NMR signal of the trifluoromethyl group of both drugs showed a downfield shift from an internal standard (trifluoroethanol) and broadening according to the increase in the lipid concentration due to their interaction with LNE particles...
February 10, 2016: AAPS PharmSciTech
Miguel Calvo-Rubio, M Isabel Burón, Guillermo López-Lluch, Plácido Navas, Rafael de Cabo, Jon J Ramsey, José M Villalba, José A González-Reyes
Calorie restriction (CR) has been repeatedly shown to prevent cancer, diabetes, hypertension, and other age-related diseases in a wide range of animals, including non-human primates and humans. In rodents, CR also increases lifespan and is a powerful tool for studying the aging process. Recently, it has been reported in mice that dietary fat plays an important role in determining lifespan extension with 40% CR. In these conditions, animals fed lard as dietary fat showed an increased longevity compared with mice fed soybean or fish oils...
June 2016: Aging Cell
Lina Song, Fengchao Zang, Mengjie Song, Gong Chen, Yu Zhang, Ning Gu
A practical and effective strategy for synthesizing PEGylated Fe3O4 nanomicelles is established. In this strategy, a magnetic fluid of the Fe3O4 nanomicelles was synthesized with amphiphilic PEGylated phospholipid as surfactant and soybean oil as stabilizer under simple mechanical stirring and subsequent ultrasonication. Transmission electron microscope (TEM) measurement indicated that the sample is monodisperse spherical Fe3O4 nanoparticles with internal core size of 9 nm and external nanomicelle shell thickness of 1...
June 2015: Journal of Nanoscience and Nanotechnology
Gabriel Dasilva, Manuel Pazos, Eduardo García-Egido, Jose Manuel Gallardo, Isaac Rodríguez, Rafael Cela, Isabel Medina
Dietary intervention with ω-3 marine fatty acids may potentially modulate inflammation and oxidative stress markers related with CVD, metabolic syndrome and cancer. The aim of this study was to evaluate whether different proportions of ω-3 EPA and DHA intake provoke a modulation of the production of lipid mediators and then, an influence on different indexes of inflammation and oxidative stress in a controlled dietary animal experiment using Wistar rats. For such scope, a lipidomic SPE-LC-ESI-MS/MS approach previously developed was applied to determine lipid mediators profile in plasma samples...
November 2015: Journal of Nutritional Biochemistry
Poonamjot Deol, Jane R Evans, Joseph Dhahbi, Karthikeyani Chellappa, Diana S Han, Stephen Spindler, Frances M Sladek
The obesity epidemic in the U.S. has led to extensive research into potential contributing dietary factors, especially fat and fructose. Recently, increased consumption of soybean oil, which is rich in polyunsaturated fatty acids (PUFAs), has been proposed to play a causal role in the epidemic. Here, we designed a series of four isocaloric diets (HFD, SO-HFD, F-HFD, F-SO-HFD) to investigate the effects of saturated versus unsaturated fat, as well as fructose, on obesity and diabetes. C57/BL6 male mice fed a diet moderately high in fat from coconut oil and soybean oil (SO-HFD, 40% kcal total fat) showed statistically significant increases in weight gain, adiposity, diabetes, glucose intolerance and insulin resistance compared to mice on a diet consisting primarily of coconut oil (HFD)...
2015: PloS One
Dawn L Hershman, Joseph M Unger, Katherine D Crew, Danielle Awad, Shaker R Dakhil, Julie Gralow, Heather Greenlee, Danika L Lew, Lori M Minasian, Cathee Till, James L Wade, Frank L Meyskens, Carol M Moinpour
PURPOSE: Musculoskeletal symptoms are the most common adverse effects of aromatase inhibitors (AIs) and can result in decreased quality of life and discontinuation of therapy. Omega-3 fatty acids (O3-FAs) can be effective in decreasing arthralgia resulting from rheumatologic conditions and reducing serum triglycerides. PATIENTS AND METHODS: Women with early-stage breast cancer receiving an AI who had a worst joint pain/stiffness score ≥ 5 of 10 using the Brief Pain Inventory-Short Form (BPI-SF) were randomly assigned to receive either O3-FAs 3...
June 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Cheng-Jen Ma, Jin-Ming Wu, Hsiang-Lin Tsai, Ching-Wen Huang, Chien-Yu Lu, Li-Chu Sun, Ying-Ling Shih, Chao-Wen Chen, Jui-Fen Chuang, Ming-Hsun Wu, Ming-Yang Wang, Ming-Tsan Lin, Jaw-Yuan Wang
BACKGROUND: A lipid emulsion composed of soybean oil (long-chain triglycerides, LCT), medium-chain triglycerides (MCT) and n-3 poly-unsaturated fatty acids (PUFAs) was evaluated for immune-modulation efficacy, safety, and tolerance in patients undergoing major surgery for gastric and colorectal cancer. METHODS: In a prospective, randomized, double-blind study, 99 patients with gastric and colorectal cancer receiving elective surgery were recruited and randomly assigned to either the study group, receiving the n-3 PUFAs enriched intravenous fat emulsion (IVFE), or the control group, receiving a lipid emulsion comprised of soybean oil and MCTs (0...
2015: Nutrition Journal
André Lisboa Rennó, Marcos José Alves-Júnior, Rafael Malagoli Rocha, Philipi Coutinho De Souza, Valéria Barbosa de Souza, Juliano Jampietro, José Vassallo, Stephen Hyslop, Gabriel Forato Anhê, Natália Guimarães de Moraes Schenka, Fernando Augusto Soares, André Almeida Schenka
Simvastatin, a competitive inhibitor of HMG-CoA reductase widely used in the treatment and prevention of hyperlipidemia-related diseases, has recently been associated to in vitro anticancer stem cell (CSC) actions. However, these effects have not been confirmed in vivo. To assess in vivo anti-CSC effects of simvastatin, female Sprague-Dawley rats with 7,12-dimethyl-benz(a)anthracene (DMBA)-induced mammary cancer and control animals were treated for 14 days with either simvastatin (20 or 40 mg/kg/day) or soybean oil (N = 60)...
April 2015: Toxicologic Pathology
Prerna Verma, Jaya Gopal Meher, Shalini Asthana, Vivek K Pawar, Mohini Chaurasia, Manish K Chourasia
CONTEXT: Nanoemulsions (NE) are one of the robust delivery tools for drugs due to their higher stability and efficacy. OBJECTIVES: The purpose of present investigation is to develop stable, effective and safe NE of docetaxel (DTX). METHODS: Soybean oil, lecithin, Pluronic F68, PEG 4000 and ethanol were employed as excipients and NEs were prepared by hot homogenization followed by ultra-sonication. NEs were optimized and investigated for different in vitro and in vivo parameters viz...
2016: Drug Delivery
Keun Sang Oh, Hyounkoo Han, Byeong Deok Yoon, Minae Lee, Hyuncheol Kim, Dong Wan Seo, Jae Hong Seo, Kwangmeyung Kim, Ick Chan Kwon, Soon Hong Yuk
Numerous studies have been performed to identify the microenvironment of solid tumors, which is responsible for the insufficient delivery of anticancer drugs to tumor cells due to the poorly organized vasculature and the increased interstitial fluid pressure. As a result, the extravasation of convection-dependent agents including NPs is severely limited. Therefore, we have demonstrated the feasibility of targeting an enhancement of docetaxel-loaded Pluronic nanoparticles (NPs) using high-intensity focused ultrasound (HIFU) as an external stimulus-induced clinical system in tumor tissue...
July 1, 2014: Colloids and Surfaces. B, Biointerfaces
Yang Li, Wen-Jun Ma, Bao-Kun Qi, Sami Rokayya, Dan Li, Jing Wang, Hong-Xia Feng, Xiao-Nan Sui, Lian-Zhou Jiang
BACKGROUND: Soybean oil may protect against cancer of the breast and prostate. It may also exert beneficial influence in combination with other oils. Here, blends (20%, v/v) of sea buckthorn oil (SEBO), camellia oil (CAO), rice bran oil (RBO), sesame oil (SEO) and peanut oil (PEO) with soybean oil (SBO) were formulated. MATERIALS AND METHODS: Oxidative stability (OS) and radical scavenging activity (RSA) of SBO and blends stored under oxidative conditions (60°C) for 24 days were studied...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
R C S Barcelos, L T Vey, H J Segat, K Roversi, Kr Roversi, V T Dias, F Trevizol, F T Kuhn, G S Dolci, C S Pase, J Piccolo, J C Veit, T Emanuelli, S C A Luz, M E Bürger
We evaluated the influence of dietary fats on ultraviolet radiation (UVR)-induced oxidative damage in skin of rats. Animals from two consecutive generations born of dams supplemented with fats during pregnancy and breastfeeding were maintained in the same supplementation: soybean-oil (SO, rich in n-6 FA, control group), fish-oil (FO, rich in n-3 FA) or hydrogenated-vegetable-fat (HVF, rich in TFA). At 90 days of age, half the animals from the 2nd generation were exposed to UVR (0.25 J/cm(2)) 3×/week for 12 weeks...
July 2014: Food and Chemical Toxicology
Ziran Wei, Weimin Wang, Ji Chen, Dejun Yang, Ronglin Yan, Qingping Cai
BACKGROUND: Nutrients such as ω-3 fatty acids including fish oil components eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress the growth and promote apoptosis of tumor cells, improve immune function and reduce the effects of systemic inflammatory response syndrome. We sought to investigate the effect of ω-3 fish oil fat emulsion-based parenteral nutrition (PN) on nutritional state, immune function, inflammatory reaction, expression of tumor factors and complication incidence in patients after surgical resection of gastric cancer...
2014: Nutrition Journal
June M Chan, Erin L Van Blarigan, Stacey A Kenfield
PURPOSE OF REVIEW: To briefly summarize the epidemiologic findings of selected lifestyle factors for prostate cancer progression, metastasis, or death, with a focus on behaviors after diagnosis where possible. We conclude by providing guidance on the lifestyle practices that physicians may wish to prioritize for discussion with their patients. RECENT FINDINGS: Growing, but still limited, evidence suggests that lifestyle factors after prostate cancer diagnosis may impact prostate-cancer-specific and overall morality...
May 2014: Current Opinion in Urology
Torfinn Moldal, Guro Løkka, Jannicke Wiik-Nielsen, Lars Austbø, Bente E Torstensen, Grethe Rosenlund, Ole Bendik Dale, Magne Kaldhusdal, Erling Olaf Koppang
BACKGROUND: Fish meal and fish oil are increasingly replaced by ingredients from terrestrial sources in the feeds for farmed salmonids due to expanding production and reduced availability of marine feed raw material. Fish oil that is rich in n-3 polyunsaturated fatty acids is considered beneficial to human health in general and to prevent intestinal inflammation and carcinogenesis in particular. In contrast, n-6 fatty acids that are present in many vegetable oils have been associated with increased risk of colitis and colon cancer in rodents and humans, as well as lowered transcription levels of certain stress and antioxidant-related genes in Atlantic salmon...
2014: BMC Veterinary Research
Tomoyuki Moriya, Kazuhiko Fukatsu, Keiichi Iwaya, Midori Noguchi, Satoshi Murakoshi, Koichi Okamoto, Toru Kubo, Daizoh Saitoh, Kazuo Hase, Junji Yamamoto
BACKGROUND: Parenteral nutrition (PN) is indispensable for meeting the caloric and substrate needs of patients who cannot receive adequate amounts of enteral nutrition. However, PN decreases hepatic mononuclear cell (MNC) numbers and impairs their functions. We examined the effects of various ratios of ω-3 to ω-6 polyunsaturated fatty acids on hepatic MNC number and function in a murine model. We focused on serum liver enzymes, lipid metabolism, cytokine production, histopathology, and the outcomes of an intraportal bacterial challenge...
April 2014: Surgery
D B Hausman, M Y Loh, W P Flatt, R J Martin
Recent studies indicate that the prevalence of obesity in adults has increased by 30% or more in the past decade, with increases in both genders and in all ethnic and racial populations and age groups. Obesity is associated with many chronic diseases and alterations in physiologic function including cardiovascular disease, hypertension, diabetes mellitus, gallbladder disease and certain types of cancer. Much attention regarding dietary influences on obesity development or prevention has focused on high fat diets...
March 1997: Asia Pacific Journal of Clinical Nutrition
Wu-Ping Wang, Xiao-Long Yan, Yun-Feng Ni, Kang Guo, Chang-Kang Ke, Qing-Shu Cheng, Qiang Lu, Lan-Jun Zhang, Xiao-Fei Li
BACKGROUND: Olive oil-based lipid emulsion (LE) and medium chain triglyceride/long chain triglyceride (MCT/LCT) emulsion are both LEs with low ω-6 polyunsaturated fat acids (PUFAs) content. However, which one of these LEs is associated with a lower infection risk in patients receiving parenteral nutrition (PN) remains unclear. The aim of the study was to compare the effects of the two LEs in PN in esophageal cancer patients undergoing surgery. METHODS: Patients with resectable esophageal carcinoma were recruited and allocated randomly to two groups...
January 2014: Nutrients
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