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Hydrogen sulfide

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https://www.readbyqxmd.com/read/29340437/a-novel-lysosome-targeted-fluorogenic-probe-based-on-5-triazole-quinoline-for-the-rapid-detection-of-hydrogen-sulfide-in-living-cells
#1
Yandong Dou, Xiaoxu Gu, Shasha Ying, Shen Zhu, Shian Yu, Wei Shen, Qing Zhu
A fluorogenic probe based on the novel fluorophore 5-triazole-quinoline was developed for the detection of hydrogen sulfide, an endogenous signaling molecule associated with the development of various diseases. The lysosome-targeted probe Lyso-HS was synthesized via C-H direct azidation from 8-aminoquinoline; it was able to detect H2S in 1 min and exhibited excellent turn-on ability with 95-fold fluorescence enhancement based on a new fluorochrome. The high quenching efficiency was further verified using time-dependent density functional theory (TDDFT)...
January 17, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29339412/the-sequence-specific-peptide-binding-activity-of-the-protein-sulfide-isomerase-agr2-directs-its-stable-binding-to-the-oncogenic-receptor-epcam
#2
M Aiman Mohtar, Lenka Hernychova, Robert O'Neill, Melanie Lawrence, Euan Murray, Borek Vojtesek, Ted R Hupp
AGR2 is an oncogenic endoplasmic reticulum (ER)-resident protein disulfide isomerase. AGR2 protein has a relatively unique property for a chaperone in that it can bind sequence-specifically to a specific peptide motif (TTIYY). A synthetic TTIYY-containing peptide column was used to affinity-purify AGR2 from crude lysates highlighting peptide selectivity in complex mixtures. Hydrogen-deuterium exchange mass spectrometry localized the dominant region in AGR2 that interacts with the TTIYY peptide to within a structural loop from amino acids 131-135 (VDPSL)...
January 16, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29338840/hydrogen-sulfide-provides-intestinal-protection-during-a-murine-model-of-experimental-necrotizing-enterocolitis
#3
Natalie A Drucker, Amanda R Jensen, Michael Ferkowicz, Troy A Markel
BACKGROUND: Necrotizing enterocolitis (NEC) continues to be a morbid surgical condition among preterm infants. Novel therapies for this condition are desperately needed. Hydrogen sulfide (H2S) is an endogenous gasotransmitter that has been found to have beneficial properties. We therefore hypothesized that intraperitoneal injection of various H2S donors would improve clinical outcomes, increase intestinal perfusion, and reduce intestinal injury in an experimental mouse model of necrotizing enterocolitis...
December 24, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29338206/application-of-ptr-ms-and-33s-isotope-labelling-for-monitoring-sulfur-processes-in-livestock-waste
#4
Frederik Rask Dalby, Michael Jørgen Hansen, Anders Feilberg
Reduced sulfur compounds emitted from livestock production cause odor nuisance for local residents. The microbial processes responsible for this are not well described in swine manure and a method for monitoring the biological processes is necessary to develop strategic abatement technologies. In this study, Proton-Transfer-Reaction Mass Spectrometry and isotope labelled sulfate was combined and applied to elucidate the sulfur processes in swine manure with high time resolution. We successfully monitored reduction of isotope 33S labelled sulfate into corresponding 33S hydrogen sulfide and that some of the 33S hydrogen sulfide was further methylated into 33S methanethiol...
January 17, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29338204/correction-to-hydrogen-sulfide-capture-from-absorption-in-polar-liquids-to-oxide-zeolite-and-metal-organic-framework-adsorbents-and-membranes
#5
Mansi S Shah, Michael Tsapatsis, J Ilja Siepmann
No abstract text is available yet for this article.
January 17, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29338122/no-co-and-h2-s-what-about-gasotransmitters-in-fish-and-amphibian-hearts
#6
REVIEW
Sandra Imbrogno, Mariacristina Filice, Maria Carmela Cerra, Alfonsina Gattuso
The gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2 S), long considered only toxicant, are produced in vivo during the catabolism of common biological molecules, and are crucial for a large variety of physiological processes. Mounting evidence is emerging that in poikilotherm vertebrates, as in mammals, they modulate the basal performance of the heart and the response to stress challenges. In this review, we will focus on teleost fish and amphibians to highlight the evolutionary importance in vertebrates of the cardiac control elicited by NO, CO and H2 S, and the conservation of the intracellular cascades they activate...
January 16, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29331374/alternative-pathway-of-h2s-and-polysulfides-production-from-sulfurated-catalytic-cysteine-of-reaction-intermediates-of-3-mercaptopyruvate-sulfurtransferase
#7
Noriyuki Nagahara, Shin Koike, Takashi Nirasawa, Hideo Kimura, Yuki Ogasawara
It has been known that hydrogen sulfide and/or polysulfides are produced from a (poly)sulfurated sulfur-acceptor substrate of 3-mercaptopyruvate sulfurtransferase (MST) via thioredoxin (Trx) reduction in vitro. In this study, we used thiosulfate as the donor substrate and the catalytic reaction was terminated on the formation of a persulfide or polysulfides. We can present alternative pathway of production of hydrogen sulfide and/or polysulfides from (poly)sulfurated catalytic-site cysteine of reaction intermediates of MST via Trx reduction...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29330066/regulation-of-vascular-tone-homeostasis-by-no-and-h2s-implications-in-hypertension
#8
REVIEW
Sevda Gheibi, Sajad Jeddi, Khosrow Kashfi, Asghar Ghasemi
Nitric oxide (NO) and hydrogen sulfide (H2S) are two gasotransmitters that are produced in the vasculature and contribute to the regulation of vascular tone. NO and H2S are synthesized in both vascular smooth muscle and endothelial cells; NO functions primarily through the sGC/cGMP pathway, and H2S mainly through activation of the ATP-dependent potassium channels; both leading to relaxation of vascular smooth muscle cells. A deficit in the NO/H2S homeostasis is involved in the pathogenesis of various cardiovascular diseases, especially hypertension...
January 9, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29326065/hydrogen-sulfide-supplement-attenuates-the-apoptosis-of-retinal-ganglion-cells-in-experimental-glaucoma
#9
Shouyue Huang, Ping Huang, Zhongjing Lin, Xiaohong Liu, Xing Xu, Lei Guo, Xi Shen, Changwei Li, Yisheng Zhong
Glaucoma is a group of neurodegenerative eye diseases characterized by progressive impairment of visual function due to loss of retinal ganglion cells (RGC). As hydrogen sulfide (H2S) was reported to play a role in the process of glaucomatous neuropathy and improve RGC survival in experimental glaucoma, the authors aimed to investigate the anti-apoptosis effect of H2S supplement in a rat glaucoma model, and further tried to explore the involved factors in the neuroprotection. A chronic ocular hypertension (COH) rat model induced by intracameral injection of cross-linking hydrogel was employed to simulate glaucoma and 288 rats were subjected to experimental procedures in the present study...
January 8, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29325692/ontogenetic-and-temperature-dependent-changes-in-tolerance-to-hypoxia-and-hydrogen-sulfide-during-the-early-life-stages-of-the-manila-clam-ruditapes-philippinarum
#10
Keita Kodama, Mitsuyasu Waku, Ryota Sone, Dai Miyawaki, Toshiro Ishida, Tetsuji Akatsuka, Toshihiro Horiguchi
Wind-induced upwelling of hypoxic waters containing hydrogen sulfide (H2S) sometimes causes mass mortalities of aquatic organisms inhabiting coastal areas, including the hypoxia-tolerant Manila clam Ruditapes philippinarum. We examined the tolerance of Manila clam to H2S under controlled laboratory conditions. Larvae and juveniles obtained by artificial fertilization or from a wild population were exposed to normoxic or to hypoxic water with or without un-ionized H2S (concentrations, 0.2-52.2 mg/L). Twenty-four-hour exposure experiments revealed ontogenetic changes in the clam's tolerance to H2S exposure: tolerance was enhanced from the larval stages to juveniles just after settlement but was attenuated as juveniles grew...
January 2, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29324846/correction-hydrogen-sulfide-alleviates-postharvest-ripening-and-senescence-of-banana-by-antagonizing-the-effect-of-ethylene
#11
Yun Ge, Kang-Di Hu, Sha-Sha Wang, Lan-Ying Hu, Xiao-Yan Chen, Yan-Hong Li, Ying Yang, Feng Yang, Hua Zhang
[This corrects the article DOI: 10.1371/journal.pone.0180113.].
2018: PloS One
https://www.readbyqxmd.com/read/29324378/impact-evaluation-of-environmental-factors-on-respiratory-function-of-asthma-patients-living-in-urban-territory
#12
Lyudmila V Veremchuk, Konstantinos Tsarouhas, Tatyana I Vitkina, Elena E Mineeva, Tatyana A Gvozdenko, Marina V Antonyuk, Valeri N Rakitskii, Karolina A Sidletskaya, Aristidis M Tsatsakis, Kirill S Golokhvast
BACKGROUND: Environmental pollution, local climatic conditions and their association with the prevalence and exacerbation of asthma are topics of intense current medical investigation. MATERIALS AND METHODS: Air pollution in the area of Vladivostock was estimated both by the index of emission volumes of "air gaseous components" (nitrogen oxide and nitrogen dioxide, formaldehyde, hydrogen sulfide, carbon monoxide) in urban atmosphere and by mass spectrometric analysis of precipitates in snow samples...
January 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29320174/comprehensive-analysis-of-changes-in-crude-oil-chemical-composition-during-biosouring-and-treatments
#13
Jeremy A Nowak, Pravin Malla Shrestha, Robert Jay Weber, Amy M McKenna, Huan Chen, John D Coates, Allen H Goldstein
Biosouring in crude oil reservoirs by sulfate-reducing microbial communities (SRCs) results in hydrogen sulfide production, precipitation of metal sulfide complexes, increased industrial costs of petroleum production, and exposure issues for personnel. Potential treatment strategies include nitrate or perchlorate injections into reservoirs. Gas chromatography with vacuum ultraviolet ionization and high-resolution time-of-flight mass spectrometry (GC-VUV-HTOF) and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) combined with electrospray ionization were applied in this study to identify hydrocarbon degradation patterns and product formations in crude oil samples from biosoured, nitrate treated, and perchlorate treated bioreactor column experiments...
January 10, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29318511/midazolam-efficacy-against-acute-hydrogen-sulfide-induced-mortality-and-neurotoxicity
#14
Poojya Anantharam, Dong-Suk Kim, Elizabeth M Whitley, Belinda Mahama, Paula Imerman, Piyush Padhi, Wilson K Rumbeiha
Hydrogen sulfide (H2S) is a colorless, highly neurotoxic gas. It is not only an occupational and environmental hazard but also of concern to the Department of Homeland Security for potential nefarious use. Acute high-dose H2S exposure causes death, while survivors may develop neurological sequelae. Currently, there is no suitable antidote for treatment of acute H2S-induced neurotoxicity. Midazolam (MDZ), an anti-convulsant drug recommended for treatment of nerve agent intoxications, could also be of value in treating acute H2S intoxication...
January 9, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29317494/hydrogen-sulfide-inhibits-kir2-and-kir3-channels-by-decreasing-sensitivity-to-the-phospholipid-pip2
#15
Junghoon Ha, Yu Xu, Takeharu Kawano, Tyler Hendon, Lia Baki, Sumanta Garai, Andreas Papapetropoulos, Ganesh Thakur, Leigh D Plant, Diomedes E Logothetis
Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain and other peripheral tissues. Phosphatidylinositol 4,5-bisphosphate (PIP2) is a key direct activator of ion channels, including Kir channels. The gasotransmitter carbon monoxide has been shown to regulate Kir channel activity by altering channel-PIP2 interactions.  Here, we tested in two cellular models the effects and mechanism of action of another gasotransmitter, hydrogen sulfide (H2S), thought to play a key role in cellular responses under ischemic conditions...
January 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29316804/renal-protective-effect-of-hydrogen-sulfide-in-cisplatin-induced-nephrotoxicity
#16
Xu Cao, Siping Xiong, Yebo Zhou, Zhi-Yuan Wu, Lei Ding, Yike Zhu, Mark Wood, Matthew Whiteman, Philip K Moore, Jin-Song Bian
AIMS: Cisplatin is a major therapeutic drug for solid tumors, but can cause severe nephrotoxicity. However, the role and therapeutic potential of hydrogen sulfide (H2S), an endogenous gaso-transmitter, in cisplatin-induced nephrotoxicity remains to be defined. RESULTS: Cisplatin led to the impairment of H2S production in vitro and in vivo by downregulating the expression level of cystathionine γ-lyase (CSE), which may contribute to the subsequent renal proximal tubule (RPT) cell death and thereby renal toxicity...
January 9, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29316454/realizing-highly-chemoselective-detection-of-h2s-in%C3%A2-vitro-and-in%C3%A2-vivo-with-fluorescent-probes-inside-core-shell-silica-nanoparticles
#17
Feiyi Wang, Ge Xu, Xianfeng Gu, Zhijun Wang, Zhiqiang Wang, Ben Shi, Cuifen Lu, Xueqing Gong, Chunchang Zhao
Hydrogen sulfide (H2S) is an appealing signaling molecule that plays fundamental roles in health and disease. However, H2S-mediated selective chemical transformations for the construction of imaging probes are limited, retarding the interrogation of H2S-related biological processes. Here, we present an alternative approach for engineering a new generation of efficient probes with a nonchemoselective moiety as a building block. To demonstrate our design concept, we developed a sulfoxide-functionalized BODIPY that exhibited a substantial redshift in its absorption and emission spectra upon reduction with H2S...
January 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29315060/comparative-study-on-the-removal-efficiency-of-hydrogen-sulfide-h2s-using-three-different-packings
#18
Shihua Pu, Zuohua Liu, Feiyun Yang, Dingbiao Long, Wen Liu, Hao Wang, Kaipei Huang, Xiu Huang
To improve the removal efficiency on hydrogen sulfide (H2S), a biofilter was developed and was made of PVC pipes. The effects of three different packings (i.e., packing A, packing B, and packing C), containing different proportions of activated carbon, sawdust, wormcast, perlite, and pig manure compost, based on different biofilter parameters on H2S removal efficiency were investigated. With the extension of running time, the H2S removal rate of packing A reached up to 90.12%, that of packing B reached a peak at 92...
January 9, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29310239/an-ortho-aldehyde-modified-probe-to-image-thiols-in-living-cells-with-enhanced-selectivity
#19
Panfei Xing, Yuchen Shi, Qiu Li, Yanxian Feng, Lei Dong, Chunming Wang
Developing fluorescent probes to image thiols in the living system may provide powerful tools to study the functions of thiol-containing biological molecules. In this study, we report the design and evaluation of a novel turn-on fluorescent probe NQNO for selective detection of thiols in living cells. By introducing an ortho-aldehyde group to NNO, a conventional compound representing a class of thiol-imaging strategy, we obtained NQNO with enhanced selectivity for thiols over the major interferent hydrogen sulfide (H2S)...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29308819/phase-controllable-fabrication-of-zinc-cobalt-sulfide-hollow-polyhedra-as-high-performance-electrocatalysts-for-the-hydrogen-evolution-reaction
#20
Bowei Zhang, Guang Yang, Chaojiang Li, Kang Huang, Junsheng Wu, Shiji Hao, Jianyong Feng, Dongdong Peng, Yizhong Huang
Structure and phase modulations allow the development of highly active, cost-effective and stable electrocatalysts for the hydrogen evolution reaction (HER) but are rather challenging. In this paper, Zn-Co-S hollow/porous polyhedra with controllable phases were fabricated via solvent-based sulfidation at room temperature followed by thermal annealing. The obtained hollow structure Zn-Co-S-300 with an amorphous phase exhibits excellent electrocatalytic HER activity, which is higher than crystalline Zn-Co sulfides annealed at a higher temperature...
January 8, 2018: Nanoscale
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