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Hydrogen sulfide

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https://www.readbyqxmd.com/read/28109134/a-novel-mitochondria-targeting-fluorescent-probe-as-the-monitor-of-hydrogen-sulfide-in-living-cells
#1
Wei Shi, Miaobo Pan, Hao Qiang, Qianqian Qiu, Wenlong Huang, Haiyan Lin, Hai Qian, Liang Ge
A novel mitochondria targeting fluorescent probe compound S-N3 as the monitor of Hydrogen Sulfide (H2 S) in living cells has been designed and synthesized in this paper. This article contained the chemosynthesis and some studies on bioactivity of the target compound in living cells. Compound S-N3 is easy to synthesize and can remain stable under the effect of pH, system and photo. In additional, it shows low cytotoxicity in cell imaging. And it can react with H2 S highly selective in PBS or FBS solution, which would cause the obvious increase of fluorescence intensity...
January 21, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28108276/hydrogen-sulfide-reduces-rage-toxicity-through-inhibition-of-its-dimer-formation
#2
Hong Zhou, Lei Ding, Zhiyuan Wu, Xu Cao, Qichun Zhang, Li Lin, Jin-Song Bian
RAGE is important in the development of neurodegenerative diseases. The present study was designed to investigate the effect of hydrogen sulfide (H2S, an endogenous gaseous mediator) on the cytotoxicity caused by RAGE activation during the chronic oxidative stress. Aβ1-42 decreased cell viability and induced cell senescence in SH-SY5Y cells. Treatment with advanced glycation end products (AGEs) induced cell injury in HEK293 cells stably expressing RAGE (HEK293-RAGE) and stimulated inflammatory responses in SH-SY5Y cells...
January 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28107968/towards-perylenequinonoid-effective-application-to-reversible-fluorescent-probe-for-monitoring-hydrogen-persulfide-in-solvents-and-living-cells
#3
Tiancheng Qiu, Haipeng Wei, Dan Cheng, Liyan Zhang, Chuanglin Jiang, Shenglian Luo, Lin Yuan, Zebing Zeng
Hydrogen persulfide (H2S2), as a direct redox form of H2S, may have its own physiological processes in maintaining intracellular redox homeostasis. The research on hydrogen persulfide was rapidly growing. As it is the actual signalling molecules derived from hydrogen sulfide, reversible detection of hydrogen persulfide changes in cells is of great significance. To address this critical need, we present a reversible fluorescent switch-on H2S2 probe, the tautomeric of 6, 7-dihydroxyperylene-1, 12-quinone (DHPQ), capable of tracking H2S2 in solvents and living cells...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107627/use-of-tissue-metabolite-analysis-and-enzyme-kinetics-to-discriminate-between-alternate-pathways-for-hydrogen-sulfide-metabolism
#4
Kristie D Cox Augustyn, Michael R Jackson, Marilyn Schuman Jorns
Hydrogen sulfide (H2S) is an endogenously synthesized signaling molecule that is enzymatically metabolized in mitochondria. The metabolism of H2S maintains optimal concentrations of the gasotransmitter and produces sulfane sulfur (S(0))-containing metabolites that may be functionally important in signaling. Sulfide:quinone oxidoreductase (SQOR) catalyzes the initial 2-electron oxidation of H2S to S(0) using coenzyme Q as electron acceptor in a reaction that requires a third substrate to act as the acceptor of S(0)...
January 20, 2017: Biochemistry
https://www.readbyqxmd.com/read/28107215/metabolic-cardiac-and-renal-effects-of-the-slow-hydrogen-sulfide-releasing-molecule-gyy4137-during-resuscitated-septic-shock-in-swine-with-pre-existing-coronary-artery-disease
#5
Benedikt L Nubaum, Josef Vogt, Ulrich Wachter, Oscar McCook, Martin Wepler, José Matallo, Enrico Calzia, Michael Gröger, Michael Georgieff, Mark E Wood, Matthew Whiteman, Peter Radermacher, Sebastian Hafner
Decreased levels of endogenous hydrogen sulfide (H2S) contribute to atherosclerosis, whereas equivocal data are available on H2S effects during sepsis. Moreover, H2S improved glucose utilization in anaesthetized, ventilated, hypothermic mice, but normothermia and/or sepsis blunted this effect. The metabolic effects of H2S in large animals are controversial. Therefore, we investigated the effects of the H2S donor GYY4137 during resuscitated, fecal peritonitis-induced septic shock in swine with genetically and diet-induced coronary artery disease (CAD)...
January 19, 2017: Shock
https://www.readbyqxmd.com/read/28106126/bi-axial-grown-amorphous-mosx-bridged-with-oxygen-on-r-go-as-a-superior-stable-and-efficient-nonprecious-catalyst-for-hydrogen-evolution
#6
Cheol-Ho Lee, Jin-Mun Yun, Sungho Lee, Seong Mu Jo, KwangSup Eom, Doh C Lee, Han-Ik Joh, Thomas F Fuller
Amorphous molybdenum sulfide (MoSx) is covalently anchored to reduced graphene oxide (r-GO) via a simple one-pot reaction, thereby inducing the reduction of GO and simultaneous doping of heteroatoms on the GO. The oxygen atoms form a bridged between MoSx and GO and play a crucial role in the fine dispersion of the MoSx particles, control of planar MoSx growth, and increase of exposed active sulfur sites. This bridging leads to highly efficient (-157 mV overpotential and 41 mV/decade Tafel slope) and stable (95% versus initial activity after 1000 cycles) electrocatalyst for hydrogen evolution...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28106111/broad-range-antiviral-activity-of-hydrogen-sulfide-against-highly-pathogenic-rna-viruses
#7
Nikolay Bazhanov, Olivier Escaffre, Alexander N Freiberg, Roberto P Garofalo, Antonella Casola
Hydrogen sulfide is an important endogenous mediator that has been the focus of intense investigation in the past few years, leading to the discovery of its role in vasoactive, cytoprotective and anti-inflammatory responses. Recently, we made a critical observation that H2S also has a protective role in paramyxovirus infection by modulating inflammatory responses and viral replication. In this study we tested the antiviral and anti-inflammatory activity of the H2S slow-releasing donor GYY4137 on enveloped RNA viruses from Ortho-, Filo-, Flavi- and Bunyavirus families, for which there is no FDA-approved vaccine or therapeutic available, with the exception of influenza...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28104983/hydrogen-sulfide-attenuates-gastric-mucosal-injury-induced-by-restraint-water-immersion-stress-via-activation-of-katp-channel-and-nf-%C3%AE%C2%BAb-dependent-pathway
#8
Hong-Zhao Sun, Shan Zheng, Kai Lu, Feng-Tian Hou, Jie-Xue Bi, Xue-Lian Liu, Shan-Shan Wang
AIM: To explore the effect of hydrogen sulfide (H2S) on restraint water-immersion stress (RWIS)-induced gastric lesions in rats and the influence of adenosine triphosphate (ATP)-sensitive potassium (KATP) channels and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway on such an effect. METHODS: Male Wistar rats were randomly divided into a control group, a physiological saline (PS) group, a sodium hydrosulfide (NaHS) group, a glibenclamide (Gl) group, Gl plus NaHS group, a pyrrolidine dithiocarbamate (PDTC) group, and a PDTC plus NaHS group...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28102393/chemically-reversible-binding-of-h2s-to-a-zinc-porphyrin-complex-towards-implementation-of-a-reversible-sensor-via-a-coordinative-based-approach
#9
Maria Strianese, Marina Lamberti, Claudio Pellecchia
Binding of hydrogen sulfide (H2S) to a zinc porphyrin complex and the stabilization of the related zinc hydrosulfido adduct are explored. High-resolution MALDI Fourier transform ion cyclotron resonance mass spectrometry (HR MALDI-FT-ICR) and (1)H NMR experiments provide evidence that HS(-) coordination occurs at the zinc centre. The coordination of HS(-) occurs in a reversible manner and modulates fluorescence emission of a tetra(N-methylpyridyl)porphine zinc complex (TMPyPZn). The results highlight the potential of TMPyPZn and related systems for the implementation of fast and simple H2S sensors via a coordinative-based approach...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28101725/sustained-release-delivery-system-of-a-slow-hydrogen-sulfide-donor-gyy-4137-for-potential-application-in-glaucoma
#10
A Patil, S Singh, C Opere, A Dash
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy. However, H2S could be toxic in a concentration greater than 200 μM and its donors are unstable in water. Therefore, this study investigated the preparation and characterization of a non-aqueous in situ gelling sustained-release delivery system for H2S donors...
January 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28099049/effects-of-hydrogen-sulfide-releasing-compounds-on-aqueous-humor-outflow-facility-in-porcine-ocular-anterior-segments-ex-vivo
#11
Jenaye Robinson, Esther Okoro, Chinoso Ezuedu, Leah Bush, Catherine A Opere, Sunny E Ohia, Ya Fatou Njie-Mbye
PURPOSE: To investigate the pharmacological actions of hydrogen sulfide (H2S)-releasing compounds l-cysteine and sodium hydrosulfide (NaHS) on aqueous humor (AH) outflow facility in porcine ocular anterior segment. METHODS: Porcine ocular anterior segments were perfused with Dulbecco's modified Eagle's medium at a constant pressure of 7.35 mmHg. After stable outflow baseline, explants were exposed to NaHS or l-cysteine. The increase in outflow generated by the H2S-releasing compounds was measured in the absence and presence of inhibitor of H2S biosynthesis (aminooxyacetic acid; AOAA), blocker of KATP channels (glibenclamide), and inhibitor of adenylyl cyclase (SQ 22536)...
January 18, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28098499/inhibition-of-leishmania-infantum-trypanothione-reductase-by-diaryl-sulfide-derivatives
#12
Francesco Saccoliti, Gabriella Angiulli, Giovanni Pupo, Luca Pescatori, Valentina Noemi Madia, Antonella Messore, Gianni Colotti, Annarita Fiorillo, Luigi Scipione, Marina Gramiccia, Trentina Di Muccio, Roberto Di Santo, Roberta Costi, Andrea Ilari
The study presented here aimed at identifying a new class of compounds acting against Leishmania parasites, the causative agent of Leishmaniasis. For this purpose, the thioether derivatives of our in-house library have been evaluated in whole-cell screening assays in order to determine their in vitro activity against Leishmania protozoan. Among them, promising results have been achieved with compound RDS 777 (6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine) (IC50 = 29.43 µM), which is able to impair the mechanism of the parasite defence against the reactive oxygen species by inhibiting the trypanothione reductase (TR) with high efficiency (Ki 0...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28096368/elemental-sulfur-aerosol-forming-mechanism
#13
Manoj Kumar, Joseph S Francisco
Elemental sulfur aerosols are ubiquitous in the atmospheres of Venus, ancient Earth, and Mars. There is now an evolving body of evidence suggesting that these aerosols have also played a role in the evolution of early life on Earth. However, the exact details of their formation mechanism remain an open question. The present theoretical calculations suggest a chemical mechanism that takes advantage of the interaction between sulfur oxides, SOn (n = 1, 2, 3) and hydrogen sulfide (nH2S), resulting in the efficient formation of a Sn+1 particle...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095390/hydrogen-sulfide-promotes-learning-and-memory-and-suppresses-proinflammatory-cytokines-in-repetitive-febrile-seizures
#14
Fei Zhuang, Xuhong Zhou, Hong Li, Xiaochun Yang, Zewu Dong, Wendi Zhou, Jian Chen
OBJECTIVE: Hydrogen sulfide (H2S), as a novel gasotransmitter, plays important roles in a number of physiological and pathological processes. Its effectiveness has been demonstrated in different types of brain disorders but not in repetitive febrile seizure (febrile status epilepticus; FSE) models. This study aims to test whether a donor of H2S sodium sulfhydrate (NaHS) is also effective for FSE in rats. METHODS: FSE was induced in rat pups on postnatal day 10 in water at 45...
January 18, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28094312/unraveling-the-microbial-processes-of-black-band-disease-in-corals-through-integrated-genomics
#15
Yui Sato, Edmund Y S Ling, Dmitrij Turaev, Patrick Laffy, Karen D Weynberg, Thomas Rattei, Bette L Willis, David G Bourne
Coral disease outbreaks contribute to the ongoing degradation of reef ecosystems, however, microbial mechanisms underlying the onset and progression of most coral diseases are poorly understood. Black band disease (BBD) manifests as a cyanobacterial-dominated microbial mat that destroys coral tissues as it rapidly spreads over coral colonies. To elucidate BBD pathogenesis, we apply a comparative metagenomic and metatranscriptomic approach to identify taxonomic and functional changes within microbial lesions during in-situ development of BBD from a comparatively benign stage termed cyanobacterial patches...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094159/performance-of-polydimethylsiloxane-membrane-contactor-process-for-selective-hydrogen-sulfide-removal-from-biogas
#16
Ebrahim Tilahun, Alper Bayrakdar, Erkan Sahinkaya, Bariş Çalli
H2S in biogas affects the co-generation performance adversely by corroding some critical components within the engine and it has to be removed in order to improve the biogas quality. This work presents the use of polydimethylsiloxane (PDMS) membrane contactor for selective removal of H2S from the biogas. Experiments were carried out to evaluate the effects of different pH of absorption liquid, biogas flowrate and temperature on the absorption performances. The results revealed that at the lowest loading rate (91mg H2S/m(2)·h) more than 98% H2S and 59% CO2 absorption efficiencies were achieved...
January 13, 2017: Waste Management
https://www.readbyqxmd.com/read/28088960/-role-and-mechanism-of-hydrogen-sulfide-in-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease-related-pulmonary-vascular-remodeling-in-rats
#17
M X Li, Y H Chen, C C Liao, F Lin, Y Bai, W J Mi, Y Sun, Y F Qi
Objective: To investigate the role and mechanism of hydrogen sulfide (H2S) in rats with chronic obstructive pulmonary disease (COPD) related pulmonary vascular remodeling. Methods: Twenty four healthy male Sprague-Dawley rats were randomly divided into 4 groups: control group, cigarette smoke (CS) group, CS+ Sodium hydrosulfide (NaHS) group and CS+ DL-propargylglycine (PPG) group. Rats in control group were fed normally and breathed clear air, and for the rest groups, passive cigarette smoke inhalation method were adopted to establish COPD model...
January 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28088675/involvement-of-water-channel-aquaporin-5-in-h2s-induced-pulmonary-edema
#18
Chunyang Xu, Lei Jiang, Yuxia Zou, Jingjing Xing, Hao Sun, Baoli Zhu, Hengdong Zhang, Jun Wang, Jinsong Zhang
Acute exposure to hydrogen sulfide (H2S) poses a significant threat to life, and the lung is one of the primary target organs of H2S. However, the mechanisms involved in H2S-induced acute pulmonary edema are poorly understood. This study aims to investigate the effects of H2S on the expression of water channel aquaporin 5 (AQP5) and to elucidate the signaling pathways involved in AQP5 regulation. In an in vivo study, C57BL6 mice were exposed to sub-lethal concentrations of inhaled H2S, and histological injury of the lungs and ultrastructure injury of the epithelial cells were evaluated...
December 30, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28087802/cytochrome-c-peroxidase-ccp-is-a-molecular-determinant-of-the-oxidative-stress-response-in-the-extreme-acidophilic-leptospirillum-sp-cf-1
#19
C Zapata, B Paillavil, R Chávez, P Álamos, G Levicán
Bioleaching processes are used to recover metals from sulfidic ores. Biofilm formation on ores is important for bioleaching because the attached microorganisms start the leaching process by concentrating ferric ions in the extracellular matrix. It has been shown that hydrogen peroxide is spontaneously generated on the surface of ores and that it negatively influences the growth and activity of microorganisms. However, the mechanism by which bioleaching microorganisms tolerate exogenous H2O2 as an adaptive trait remains elusive...
January 12, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28087442/hydrogen-sulfide-protects-against-endoplasmic-reticulum-stress-and-mitochondrial-injury-in-nucleus-pulposus-cells-and-ameliorates-intervertebral-disc-degeneration
#20
Daoliang Xu, Haiming Jin, Jianxia Wen, Jiaoxiang Chen, Deheng Chen, Ningyu Cai, Yongli Wang, Jianle Wang, Yu Chen, Xiaolei Zhang, Xiangyang Wang
It has been suggested that excessive apoptosis in intervertebral disc cells induced by inflammatory cytokines, such as interleukin (IL)-1β, is related to the process of intervertebral disc degeneration (IVDD). Hydrogen sulfide (H2S), a gaseous signaling molecule, has drawn attention for its anti-apoptosis role in various pathophysiological processes in degenerative diseases. To date, there has been no investigation of the correlation of H2S production and IVDD or of the effects of H2S on IL-1β-induced apoptosis in nucleus pulposus (NP) cells...
January 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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