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https://www.readbyqxmd.com/read/28739751/the-clinicopathological-factors-associated-with-disease-progression-in-luminal-a-breast-cancer-and-characteristics-of-metastasis-a-retrospective-study-from-a-single-center-in-china
#1
Jingming Ye, Wenjun Wang, Ling Xin, Sioned Owen, Ling Xu, Xuening Duan, Yuanjia Cheng, Hong Zhang, Shuang Zhang, Ting Li, Yinhua Liu
BACKGROUND/AIM: This study investigated the clinicopathological factors associated with outcomes in patients with Luminal A breast cancer. PATIENTS AND METHODS: Retrospective analysis of the association of clinicopathological factors and breast cancer outcome in 421 patients with newly-diagnosed Luminal-A breast cancer that were enrolled from January 2008 to December 2014. Clinicopathological data were analyzed to validate the relationship with disease-free survival (DFS) and overall survival (OS)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739719/expression-of-osteoprotegrin-is-enhanced-in-lung-cancer-tissues-and-promotes-aggressive-cellular-traits-in-h3122-lung-cancer-cells
#2
Zhen Yu, Andrew J Sanders, Sioned Owen, Shan Cheng, Xiaomei Yang, Wen G Jiang
BACKGROUND: Osteoprotegrin (OPG), a secreted protein and a member of the tumor necrosis factor receptor superfamily has been well-characterized and is an important regulator of bone remodeling by blocking osteoclast maturation thus preventing osteolysis. In recent years, OPG has been reported to have an association with the malignant capacity of various cancer types and cancer-associated bone metastasis, although the mechanisms of this are not clearly understood. MATERIALS AND METHODS: In this study, OPG expression was analyzed in human lung cancer tissue and normal tissue based on the dataset of The Cancer Genome Atlas and Oncomine...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28730730/renal-impairment-hampers-bisphosphonate-treatment-in-a-quarter-of-lung-cancer-patients-with-bone-metastasis
#3
Katalin Fábián, Rita Puskás, Tímea Kakuk, László Prés, Dorottya Fejes, Zsolt Szegedi, Lívia Rojkó, Zoltán Szállási, Balázs Döme, Orsolya Pipek, Judit Moldvay
Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function parameters. Co-morbidities included hypertension (50%), COPD (33%) and diabetes mellitus (15%). Statistical analysis was performed with Fisher's exact tests and a Cox proportional hazards model...
July 21, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28725538/a-rare-case-of-solitary-kidney-metastasis-following-primary-laryngeal-squamous-cell-carcinoma
#4
Sharon Del Vecchio, Robert Ellis, Kylie Gallagher, Keng Lim Ng, Li Ma, Geoffrey Strutton, Simon Wood
Laryngeal cancer is the 14th most common malignancy worldwide, and its common subtype squamous cell carcinoma (SCC) is highly associated with tobacco use and long-term alcohol consumption. The incidence of distant metastasis from a primary laryngeal cancer has been reported to be very low, between 6.5% and 8.5%, according to published tumour registry data. Distant metastases of laryngeal SCC most commonly involve the lung, liver, bone and mediastinum, seldom involving the kidney. Renal metastasis has been well established in many other cancers such as lymphoma, lung, breast and gastric carcinoma...
2017: Journal of Kidney Cancer and VHL
https://www.readbyqxmd.com/read/28720841/novel-immunohistochemistry-based-signatures-to-predict-metastatic-site-of-triple-negative-breast-cancers
#5
Sergey Klimov, Padmashree Cg Rida, Mohammed A Aleskandarany, Andrew R Green, Ian O Ellis, Emiel Am Janssen, Emad A Rakha, Ritu Aneja
BACKGROUND: Although distant metastasis (DM) in breast cancer (BC) is the most lethal form of recurrence and the most common underlying cause of cancer related deaths, the outcome following the development of DM is related to the site of metastasis. Triple negative BC (TNBC) is an aggressive form of BC characterised by early recurrences and high mortality. Athough multiple variables can be used to predict the risk of metastasis, few markers can predict the specific site of metastasis...
July 18, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28706141/epidermal-growth-factor-receptor-is-associated-with-the-onset-of-skeletal-related-events-in-non-small-cell-lung-cancer
#6
Shu-Mei Huang, Jin-Ji Yang, Hua-Jun Chen, Si-Pei Wu, Xiao-Yan Bai, Qing Zhou, Hai-Yan Tu, Yi-Long Wu
BACKGROUND: Bone metastasis and skeletal related events (SREs) are common in non-small cell lung cancer (NSCLC). Patients with mutant epidermal growth factor receptor (EGFR) could benefit from tyrosine kinase inhibitors (TKIs). However, it is unclear whether SRE is influenced by EGFR status. We aimed to evaluate the correlation of EGFR status and TKIs with the incidence of SREs. METHODS: We conducted a retrospective study of stage IV NSCLC patients with bone metastasis...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28700994/brain-metastasis-from-colorectal-cancer-predictors-and-treatment-outcomes
#7
Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Kazuhito Sasaki, Koji Murono, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Toshiaki Watanabe
OBJECTIVE: Difficulties are associated with the management of brain metastasis (BM), which portends a poor prognosis in the treatment of colorectal cancer (CRC). The aim of the present study was to identify risk factors for BM in CRC and evaluate the outcomes of various treatment modalities. METHODS: We retrospectively reviewed data on a total of 2,238 patients with primary CRC who underwent surgical resection at our hospital between 1999 and 2014. Predictive factors for BM and prognostic factors after the diagnosis of BM were examined by univariate and multivariate analyses using Cox proportional hazards models...
July 13, 2017: Oncology
https://www.readbyqxmd.com/read/28698809/p-rex1-expression-in-invasive-breast-cancer-in-relation-to-receptor-status-and-distant-metastatic-site
#8
Jonathan D Marotti, Kristen E Muller, Laura J Tafe, Eugene Demidenko, Todd W Miller
BACKGROUND: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-Rex1) has been implicated in cancer growth, metastasis, and response to phosphatidylinositol 3-kinase (PI3K) inhibitor therapy. The aim of this study was to determine whether P-Rex1 expression differs between primary and metastatic human breast tumors and between breast cancer subtypes. DESIGN: P-Rex1 expression was measured in 133 specimens by immunohistochemistry: 40 and 42 primary breast tumors from patients who did versus did not develop metastasis, respectively, and 51 breast-derived tumors from metastatic sites (36 of which had matching primary tumors available for analysis)...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28698458/integrin-%C3%AE-v%C3%AE-3-signaling-in-tumor-induced-bone-disease
#9
REVIEW
Kristin A Kwakwa, Julie A Sterling
Tumor-induced bone disease is common among patients with advanced solid cancers, especially those with breast, prostate, and lung malignancies. The tendency of these cancers to metastasize to bone and induce bone destruction is, in part, due to alterations in integrin expression and signaling. Substantial evidence from preclinical studies shows that increased expression of integrin αvβ3 in tumor cells promotes the metastatic and bone-invasive phenotype. Integrin αvβ3 mediates cell adhesion to several extracellular matrix proteins in the bone microenvironment which is necessary for tumor cell colonization as well as the transmission of mechanical signals for tumor progression...
July 8, 2017: Cancers
https://www.readbyqxmd.com/read/28694161/cxcr4-targeted-dendrimer-for-anti-cancer-drug-delivery-and-breast-cancer-cell-migration-inhibition
#10
Chuda Chittasupho, Songyot Anuchapreeda, Narong Sarisuta
CXCR4 and its ligand CXCL12 play a critical role in the metastasis of various types of cancer including breast cancer. Breast tumors preferentially metastasize to the lung, bones and distant lymph nodes, secreting high levels of CXCL12. We hypothesized that targeted inhibition of CXCR4 in breast cancer cells should suppress CXCR4-positive tumor cells toward secondary metastatic sites. In the present study, the efficacy of CXCR4 targeted dendrimers carrying DOX (LFC131-DOX-D4) on cellular binding, cytotoxicity, and migration of BT-549-Luc and T47D breast cancer cells was investigated...
July 7, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28685085/diffuse-fluorodeoxyglucose-positron-uptake-in-the-bone-marrow-of-a-patient-with-granulocyte-colony-stimulating-factor-producing-pleomorphic-carcinoma-of-the-lung-a-case-report
#11
Takashi Makino, Yoshinobu Hata, Hajime Otsuka, Satoshi Koezuka, Nao Kikuchi, Kazutoshi Isobe, Naobumi Tochigi, Kazutoshi Shibuya, Sakae Homma, Akira Iyoda
The current study presents the case of a 66-year-old male presenting with fever and chest pain. Chest enhanced computed tomography scanning revealed a mass shadow in the right upper lobe with chest wall invasion. 18-Fluorodeoxyglucose-positron emission tomography (FDG-PET) identified the localized uptake of the mass lesion in the right upper lobe, in addition to diffuse uptake by the bone marrow. The laboratory data on admission revealed marked leukocytosis and an elevated C-reactive protein level (CRP). Serum concentrations of granulocyte colony-stimulating factor (G-CSF) and interleukin 6 were increased...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28684728/a-rare-case-of-sarcomatoid-carcinoma-of-the-lung-with-spine-metastasis-including-a-literature-review
#12
Hafiza Sobia Arshad, Rizwan Ahmed Dudekula, Masooma Niazi, Sandeep Malik, Misbahuddin Khaja
BACKGROUND Sarcomatoid carcinoma is a rare, aggressive, malignant cancer composed of sarcoma and sarcoma-like components, and can occur in different organs such as the thyroid gland, bone, skin, breast, pancreas, liver, urinary tract, and lung. Pulmonary sarcomatoid carcinoma accounts for only a small percentage of lung cancers and has histological variants that include pleomorphic carcinoma, giant cell carcinoma, spindle cell carcinoma, carcinosarcoma, and pulmonary blastoma. CASE REPORT Here, we present a case of sarcomatoid carcinoma in a 63-year-old HIV-positive Hispanic male who presented with back pain, dry cough, and weight loss...
July 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28680205/an-unusual-case-of-myocardial-localization-of-non-small-cell-lung-cancer-metastasis-a-case-report-and-review-of-literature
#13
Luca Tagliabue, Giulia Manfrinato, Andrea Luciani
Positron emission tomography (PET) using 18F-fluorodeoxyglucose (18F-FDG) is useful for staging non-small cell lung cancer (NSCLC), decide the appropriate initial management, and evaluate the response to therapy. Metastatic spreading is very common during the course of NSCLC and principal localization sites include: regional and mediastinal lymph nodes and organs such as the contralateral lung parenchyma, bone, brain, adrenal gland, pleura, and liver. Myocardial localizations are very rare, often asymptomatic, and difficult to diagnose...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28677013/a-meta-analysis-survey-of-appropriate-bone-turnover-markers-in-the-detection-of-bone-metastasis-in-lung-cancer
#14
Jianda Huang, Tongjie Gu, Jun Ying
BACKGROUND: A number of studies have investigated the clinical significance of bone turnover markers (BTMs) for the diagnosis of bone metastasis (BM) in lung cancer; however, they led to contradictory results. The aim of this meta-analysis was to investigate whether BTMs differ between lung cancer patients with and without BM. METHODS: Articles were identified by searching Medline, Embase, Web of Science and Scopus. The studies that were identified were pooled and the weighted mean difference (WMD) and its corresponding 95% confidence interval (CI) were calculated...
July 4, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28672103/shingosine-1-phosphate-suppresses-chondrosarcoma-metastasis-by-up-regulation-of-tissue-inhibitor-of-metalloproteinase-3-through-suppressing-mir-101-expression
#15
Chun-Hao Tsai, Dong-Ying Yang, Chih-Yang Lin, Tsung-Ming Chen, Chih-Hsin Tang, Yuan-Li Huang
Chondrosarcoma is the second most common primary malignancy form of bone cancer, exhibiting resistance to chemotherapy and radiation therapy as well as developing high metastasis ability in late stage tumors. Thus, understanding the metastatic processes of chondrosarcoma is considered a strategy for treatment of this disease. Sphingosine 1-phosphate (S1P), a bioactive sphingolipid, is produced intracellularly by sphingosine kinase (SphK) and is regarded as a second signaling molecule that regulates inflammation, proliferation, angiogenesis, and metastasis...
July 3, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28671048/neuron-specific-enolase-histopathological-types-and-age-as-risk-factors-for-bone-metastases-in-lung-cancer
#16
Yang Zhou, Wen-Zhao Chen, Ai-Fen Peng, Wei-Lai Tong, Jia-Ming Liu, Zhi-Li Liu
Lung cancer is a malignant tumor with high metastatic ability and bone is the most common site of distant metastasis of it. However, the independent risk factors for bone metastases of lung cancer remain largely to be elucidated. Here, we conducted a retrospective study to evaluate the correlation between clinical-pathological parameters, serum levels of neuron-specific enolase and CYFRA21-1, and bone metastases in lung cancer patients. The results revealed that patients with bone metastases were younger than those without metastases...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28668831/choline-deficient-diet-induced-fatty-liver-is-a-metastasis-resistant-microenvironment
#17
Miki Nakamura, Atsushi Suetsugu, Kosuke Hasegawa, Takuro Matsumoto, Hitomi Aoki, Takahiro Kunisada, Masahito Shimizu, Shigetoyo Saji, Hisataka Moriwaki, Robert M Hoffman
BACKGROUND/AIM: Fatty liver disease is increasing in the developed and developing world. Liver metastasis from malignant lymphoma in the fatty liver is poorly understood. In a previous report, we developed color-coded imaging of the tumor microenvironment (TME) of the murine EL4-RFP malignant lymphoma during metastasis, including the lung. In the present report, we investigated the potential and microenvironment of the fatty liver induced by a choline-deficient diet as a metastatic site in this mouse lymphoma model...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28664617/down-regulation-of-long-noncoding-rna-malat1-by-rna-interference-inhibits-proliferation-and-induces-apoptosis-in-multiple-myeloma
#18
Hui Liu, Huihan Wang, Bin Wu, Kun Yao, Aijun Liao, Miao Miao, Yang Li, Wei Yang
Multiple myeloma (MM) is a neoplastic plasma-cell disorder characterized by abnormal proliferation of monoclonal plasma cells in the bone marrow. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an evolutionarily highly conserved long non-coding RNA was originally identified in metastatic non-small cell lung cancer and has been reported to be up-regulated in many other cancers. However, the function of MALAT1 in MM remains unknown. In the present study, by transfecting MM cells with MALAT1-specific short hairpin RNA (shRNA) expression plasmids, the role of MALAT1 in the proliferation and apoptosis of MM cells was investigated in vitro, and the tumorigenicity of MALAT1-silenced cells was evaluated in vivo...
June 30, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28660220/f-18-fdg-pet-ct-imaging-of-eccrine-sweat-gland-carcinoma-of-the-scrotum-with-extensive-regional-and-distant-metastases
#19
Jin-Suk Kim
Eccrine carcinoma is an extremely rare malignant skin cancer arising from eccrine sweat glands with a high metastatic potential. It mainly occurs in the elderly, with equal incidence in both sexes. It usually spreads to regional lymph nodes, with liver, lungs, and bones being the most common sites of distant metastasis. Because of tumor rarity, little is known about the value of F-18 FDG PET/CT in evaluating this disease. Our case report aims to increase current knowledge of F-18 FDG PET/CT in eccrine sweat gland carcinoma as a noninvasive imaging tool for assessing the extension of the disease and detecting distant metastases...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28659974/esophageal-cancer-metastases-to-unexpected-sites-a-systematic-review
#20
REVIEW
Osama Shaheen, Abdulaziz Ghibour, Bayan Alsaid
The most common pattern of esophageal cancer metastases (ECM) is to the lymph nodes, lung, liver, bones, adrenal glands, and brain. On the other hand, unexpected metastasis (UM) spread to uncommon sites has increasingly reported and consequently affected the pathway of diagnosis, staging, and management. Using the PubMed database, a systematic search of the following headings "Esophageal" and "Metastasis" or "Metastases" was performed, 10049 articles were identified, and the articles were included if they demonstrated unexpected ECM...
2017: Gastroenterology Research and Practice
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