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https://www.readbyqxmd.com/read/28923109/the-outcome-of-prostate-cancer-patients-treated-with-curative-intent-strongly-depends-on-survival-after-metastatic-progression
#1
Mariarosa Pascale, Che Ngwa Azinwi, Barbara Marongiu, Gianfranco Pesce, Flavio Stoffel, Enrico Roggero
BACKGROUND: Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of metastatic patients has become increasingly complex as novel therapeutic strategies have emerged. This study aims at evaluating the impact of the first metastatic progression on the outcome of PCa patients treated with curative intent. METHODS: The analysis was conducted using data of 913 cases of localized PCa diagnosed between 2000 and 2014...
September 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28922402/new-insights-into-the-metastatic-behavior-after-breast-cancer-surgery-according-to-well-established-clinicopathological-variables-and-molecular-subtypes
#2
Oreste Claudio Buonomo, Emanuele Caredda, Ilaria Portarena, Gianluca Vanni, Augusto Orlandi, Claudia Bagni, Giuseppe Petrella, Leonardo Palombi, Paolo Orsaria
Despite advances in treatment, up to 30% of patients with early breast cancer (BC) experience distant disease relapse. However, a comprehensive understanding of tumor spread and site-specific recurrence patterns remains lacking. This retrospective case-control study included 103 consecutive patients with metastatic BC admitted to our institution (2000-2013). Cases were matched according to age, tumor biology, and clinicopathological features to 221 patients with non-metastatic BC (control group). The median follow-up period among the 324 eligible patients was 7...
2017: PloS One
https://www.readbyqxmd.com/read/28920149/efficacy-and-safety-of-153-sm-edtmp-as-treatment-of-painful-bone-metastasis-a-large-single-center-study
#3
Hélène Kolesnikov-Gauthier, Nathalie Lemoine, Emmanuelle Tresch-Bruneel, Anaïs Olivier, Aurore Oudoux, Nicolas Penel
PURPOSE: The purpose of this study is to assess the efficacy of (153)Sm-EDTMP (Quadramet®) in a clinical setting. METHODS: We have conducted a retrospective study of all consecutive patients (pts) treated with (153)Sm-EDTMP for painful bone metastases. At each visit (before and after treatment), four parameters were collected: (i) pain assessment according to the 10-step visual analogue scale (VAS), (ii) sleep disturbance related to pain, (iii) dose of analgesic medication, and (iv) answer to the following closed question "Do you think you obtained a benefit from treatment?" Success of treatment was defined by the combination of these four parameters...
September 17, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28915886/prognostic-factors-in-patients-with-loco-regionally-advanced-gastric-cancer
#4
Bo Hultman, Ulf Gunnarsson, Peter Nygren, Magnus Sundbom, Bengt Glimelius, Haile Mahteme
BACKGROUND: The aim of this study was to investigate epidemiologic and prognostic factors relevant to the treatment of loco-regionally advanced gastric cancer (GC). METHODS: Two hundred and fifty-five patients with GC were identified in Uppsala County between 2000 and 2009. Patient records were analyzed for loco-regionally advanced GC defined as tumor with peritoneal involvement, excluding serosal invasion from the primary tumor only, at primary diagnosis or during follow-up...
September 15, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28905808/patient-with-metastatic-breast-cancer-presenting-as-acute-cholecystitis-with-one-year-survival-on-hormonotherapy
#5
Mateusz Zamkowski, Michał Kąkol, Wojciech Makarewicz, Jerzy Ropel, Maciej Bobowicz
Breast cancer has high metastatic potential with distant metastases involving mainly lungs, liver and bones. Less frequently it gives distant spread to other organs. Herein we would like to present a very rare case of an acute cholecystitis which turned out to be a metastatic breast cancer in previously healthy woman. A female patient, 64-years old, presented to the emergency department with symptoms of biliary colic and acute abdomen. During the emergency cholecystectomy, we diagnosed the gallbladder empyema with thickened wall...
August 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28903844/bone-marrow-involvement-in-metastatic-pediatric-ewing-sarcoma
#6
Saadiya Javed Khan, Irfana Ishaq, Haleema Saeed, Muhammad Bilal Fayyaz, Syed Ali Shazif Baqari, Rabia Mohammad Wali
OBJECTIVE: To evaluate the frequency of bone marrow involvement with metastatic lung and bone sites in newly-diagnosed pediatric patients with Ewing sarcoma (ES). STUDY DESIGN: An observational study. PLACE AND DURATION OF STUDY: Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, from January 2010 to October 2015. METHODOLOGY: Newly-diagnosed pediatric-age patients with ES were inducted. Ten patients were excluded because bone marrow aspiration/biopsy (BMAB) was not done...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28900854/relationships-between-serum-psa-levels-gleason-scores-and-results-of-68ga-psmapet-ct-in-patients-with-recurrent-prostate-cancer
#7
Yasemin Sanli, Serkan Kuyumcu, Oner Sanli, Fikret Buyukkaya, Ayça İribaş, Goksel Alcin, Emin Darendeliler, Yasemin Ozluk, Sevda Ozel Yildiz, Cüneyt Turkmen
AIM: To investigate the relationship between serum PSA level, Gleason score of PCa and the outcomes of Ga(68)-PSMA PET/CT in patients with recurrent PCa. METHODS: A total of 109 consecutive patients (median age 71 years; range 48-89 years) who had PSA recurrence after RP and/or hormonotherapy and/or radiotherapy were included in this study. Local recurrences, lymph node metastasis (pelvic, abdominal and/or supradiaphragmatic), bone metastases (oligometastatic/multimetastatic) and other metastatic sites (lung, liver, brain, etc) were documented...
September 12, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28893744/survival-after-bone-metastasis-by-primary-cancer-type-a-danish-population-based-cohort-study
#8
Elisabeth Svensson, Christian F Christiansen, Sinna P Ulrichsen, Mikael R Rørth, Henrik T Sørensen
OBJECTIVE: In the 10 most common primary types with bone metastases, we aimed to examine survival, further stratifying on bone metastases only or with additional synchronous metastases. METHODS: We included all patients aged 18 years and older with incident hospital diagnosis of solid cancer between 1994 and 2010, subsequently diagnosed with BM until 2012. We followed patients from date of bone metastasis diagnosis until death, emigration or 31 December 2012, whichever came first...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28893026/superior-vena-cava-as-gateway-to-heart-metastatic-breast-carcinoma-causing-ball-in-a-loop-metastasis-to-right-atrium
#9
Harpreet Singh Sandhu, Sampath Kumar Mahadevappa Mahendrakar, Sulaiman Sadruddin Ladhani, Azizullah Hafizullah Khan, Yunus Shafi Loya
Breast carcinoma is the most common invasive cancer in women worldwide. It metastasizes commonly to bone, lungs, regional lymph nodes and brain. Cardiac metastasis of lung and breast cancers is a known but rare complication of advanced disease with tumour metastasising to pericardium via the locoregional lymphatic system. Here we present a case of 59-year-old female presenting with right upper limb oedema, facial puffiness and features of Superior Vena Cava (SVC) syndrome 15 years after mastectomy and adjuvant chemotherapy, radiotherapy for carcinoma of the right breast...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892080/differential-effects-on-lung-and-bone-metastasis-of-breast-cancer-by-wnt-signalling-inhibitor-dkk1
#10
Xueqian Zhuang, Hao Zhang, Xiaoyan Li, Xiaoxun Li, Min Cong, Fangli Peng, Jingyi Yu, Xue Zhang, Qifeng Yang, Guohong Hu
Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and neutrophil recruitment in lung metastases by antagonizing cancer cell non-canonical WNT/PCP-RAC1-JNK signalling. In the lungs, DKK1 also inhibits WNT/Ca(2+)-CaMKII-NF-κB signalling and suppresses LTBP1-mediated TGF-β secretion of cancer cells...
September 11, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28887281/cerebrospinal-fluid-leak-rhinorrhea-after-systemic-erlotinib-chemotherapy-for-metastatic-lung-cancer-a-familiar-problem-from-an-unfamiliar-culprit
#11
Blake Priddy, Douglas A Hardesty, André Beer-Furlan, Bradley Otto, Daniel M Prevedello
BACKGROUND: Cerebrospinal fluid (CSF) rhinorrhea after medical therapy for pituitary prolactinoma is a rare but well-described phenomenon. To our knowledge, no CSF leaks have been reported after targeted medical treatment of pituitary or anterior skull base metastases. We report this unusual case to raise awareness of spontaneous CSF leaks in the setting of skull base metastatic disease. CASE PRESENTATION: A 66-year-old woman presented with EGFR-mutant Stage IV adenocarcinoma of the lung...
September 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28881488/case-series-of-pleomorphic-carcinomas-of-the-lung-treated-with-nivolumab
#12
Masaki Kanazu, Takeshi Uenami, Yukihiro Yano, Saeko Nakatsubo, Yuki Hosono, Mikako Ishijima, Yuki Akazawa, Toshihiko Yamaguchi, Koji Urasaki, Masahide Mori, Soichiro Yokota
Pleomorphic carcinoma (PC) of the lung is a rare type of non-small cell lung cancer, exhibiting aggressive behavior and resistance to chemotherapy and radiotherapy. A previous study reported that PCs expressed high levels of PD-L1, suggesting the potential efficacy of immune checkpoint inhibitors in these tumors. We retrospectively reviewed the clinical records of three patients with PC of the lung treated with nivolumab: a 59-year-old woman (Case 1), a 66-year-old man (Case 2), and an 83-year-old man (Case 3)...
September 7, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28878853/bilateral-renal-metastasis-of-h%C3%A3-rthle-cell-thyroid-cancer-with-discordant-uptake-between-i-131-sodium-iodide-and-f-18-fdg
#13
Apichaya Claimon, Minseok Suh, Gi Jeong Cheon, Dong Soo Lee, E Edmund Kim, June-Key Chung
Renal metastasis of thyroid cancer is extremely rare. We report the case of a 62-year-old woman with Hürthle cell thyroid cancer (HCTC) with lungs, bones, and bilateral kidneys metastases. The renal metastatic lesions were clearly demonstrated by (131)I whole body scan (WBS) with SPECT/CT. However, they exhibited false-negative results in (18)F-FDG PET/CT, kidney ultrasonography, and contrast-enhanced CT scan. The findings imply that tumors have low glucose metabolism and are able to accumulate radioiodine, which is not commonly found in the relatively aggressive nature of HCTC...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28874890/patterns-of-spread-and-prognostic-implications-of-lung-cancer-metastasis-in-an-era-of-driver-mutations
#14
F Hsu, A De Caluwe, D Anderson, A Nichol, T Toriumi, C Ho
BACKGROUND: In the present study, we examined the pattern of metastatic spread in patients with advanced non-small-cell lung cancer (nsclc) and the effect of EGFR mutations. METHODS: Patients were identified from a provincial cancer registry, and individual medical records were reviewed. Patients were included if they had stage iv nsclc and underwent diagnostic EGFR mutation testing. Patients were divided into EGFR mutation-positive (EGFR+) and EGFR wild type (wt) cohorts...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28871659/overexpression-of-her-2-via-immunohistochemistry-in-canine-urinary-bladder-transitional-cell-carcinoma-a-marker-of-malignancy-and-possible-therapeutic-target
#15
F Millanta, J Impellizeri, L McSherry, G Rocchigiani, L Aurisicchio, G Lubas
Transitional cell carcinoma (TCC) is the most commonly diagnosed neoplasm in the urinary bladder. Distant metastases to the regional lymph nodes, lungs, abdominal organs or bones are noted in up to 50% of dogs at time of death. Surgical excision is often not practical as TCC typically involve the trigone of the bladder and/or occurs multifocally throughout the bladder with field cancerization. Therapeutic approaches are very challenging and the requirement to evaluate alternative therapeutic protocols that may prolong survival times in dogs bearing these tumours is compelling...
September 4, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28868021/a-case-of-recurrent-breast-cancer-identified-by-pulmonary-tumor-thrombotic-microangiopathy
#16
Tomomi Abe, Ippei Fukada, Taro Shiga, Hidetomo Morizono, Koichi Ikebata, Tomoko Shibayama, Kokoro Kobayashi, Takuji Iwase, Shinji Ohno, Yoshinori Ito
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare, cancer-related, pulmonary complication that causes hypoxia and pulmonary hypertension. We report on a 42-year-old woman who was diagnosed with recurrent breast cancer that was detected due to the presence of PTTM. Eleven months after surgery for heterochronous bilateral cancer of the left breast, she developed progressive dyspnea but computerized tomography showed no pulmonary thromboembolism, and a transthoracic echocardiography revealed mild pulmonary hypertension...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28862125/solitary-adrenal-metastases-from-breast-invasive-ductal-carcinoma
#17
Cezar Stroescu, Iulian Gilca, Dragoş Chirita, Radu Poenaru, Ana Puşcaşu, Diana Pescaru, Adelina Birceanu, Cornelia Niţipir, Narcis Copcă
The usual neoplastic dissease involving suprarenal glands are adrenal metastaes. The majority of suprarenal metastatic disease arise from lung cancer, followed by the stomach and colon cancer, oesophagus, the liver/bile ducts cancer and renal cell carcinoma. Invasive mammary carcinoma usually spreads to the bones, lungs, lymph nodes, liver and the brain. Adrenal gland metastases from invasive no special type carcinoma represents an extremly low rate number of cases. We discuss about a 66 year old patient who presented with a solitary adrenal metastases from triple negative breast invasive carcinoma...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28840139/influence-of-the-different-primary-cancers-and-different-types-of-bone-metastasis-on-the-lesion-based-artificial-neural-network-value-calculated-by-a-computer-aided-diagnostic-system-bonenavi-on-bone-scintigraphy-images
#18
Takuro Isoda, Shingo BaBa, Yasuhiro Maruoka, Yoshiyuki Kitamura, Keiichiro Tahara, Masayuki Sasaki, Masamitsu Hatakenaka, Hiroshi Honda
OBJECTIVES: BONENAVI, a computer-aided diagnostic system, is used in bone scintigraphy. This system provides the artificial neural network (ANN) and bone scan index (BSI) values. ANN is associated with the possibility of bone metastasis, while BSI is related to the amount of bone metastasis. The degree of uptake on bone scintigraphy can be affected by the type of bone metastasis. Therefore, the ANN value provided by BONENAVI may be influenced by the characteristics of bone metastasis...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28836445/clinical-correlates-and-prognostic-value-of-different-metastatic-sites-in-metastatic-renal-cell-carcinoma
#19
Omar Abdel-Rahman
AIM: Real life data on the clinical correlates and prognostic value of metastatic sites in metastatic renal cell carcinoma (RCC) are needed. This parameter was assessed in RCC patients registered within the surveillance, epidemiology and end results (SEER) database. METHODS: Data were obtained from the National Cancer Institute-SEER database spanning 2010-2013; and it has been accessed through SEER*Stat program to determine the clinical correlates and prognosis of RCC patients with distant metastases according to the site of metastasis...
August 24, 2017: Future Oncology
https://www.readbyqxmd.com/read/28835603/clinical-characteristics-and-prognostic-factors-in-bone-metastases-from-lung-cancer
#20
Li Zhang, Zhixin Gong
BACKGROUND This study investigated the prognostic factors of bone metastases from lung cancer. MATERIAL AND METHODS From March 2014 to March 2015, 168 patients with bone metastases from lung cancer treated at our hospital were included and the clinical data were reviewed. The Kaplan-Meier survival curves were calculated and analyzed using the log-rank univariate test. Multivariate regression analysis was conducted using Cox's regression model. RESULTS The overall median survival of the 168 patients was 13 months...
August 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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