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HbA1c AND keiko arai

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https://www.readbyqxmd.com/read/27330726/relationship-between-the-efficacy-of-oral-antidiabetic-drugs-and-clinical-features-in-type-2-diabetic-patients-jddm38
#1
Azuma Kanatsuka, Yasunori Sato, Koichi Kawai, Koichi Hirao, Masashi Kobayashi, Atsunori Kashiwagi, Nobuyuki Abe, Keiko Arai, Hiroshi Fujiya, Yoshihide Fukumoto, Fumihiko Dake, Tomohiro Iizumi, Masaaki Ito, Koichi Iwasaki, Akira Kanamori, Sumio Kato, Masakazu Kato, Akira Kawara, Kenichi Kimura, Kazumasa Chikamori, Kotaro Iemitsu, Shigetake Kou, Mikihiko Kudo, Yoshio Kurihara, Gendai Lee, Akira Tsuruoka, Naoki Manda, Kiyokazu Matoba, Hiroshi Hayashi, Masae Minami, Nobuichi Kuribayashi, Kazuhiro Miyazawa, Yasuko Chiba, Takeshi Osonoi, Shin Nakamura, Hideo Sasaki, Katsutoshi Komori, Mariko Oishi, Akira Okada, Fuminobu Okuguchi, Morifumi Yanagisawa, Hidekatsu Sugimoto, Hiromichi Sugiyama, Masahiko Takai, Masato Takaki, Hiroshi Takamura, Hiroshi Takeda, Hiroshi Takeda, Kokichi Tanaka, Takashi Miwa, Osamu Tomonaga, Madoka Taguchi, Katsuya Yamazaki, Takako Wada, Noriharu Yagi, Kuniko Yamaoka, Atsuyoshi Yuhara
AIMS/INTRODUCTION: We carried out an observational cohort study to examine the relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetics. MATERIALS AND METHODS: We analyzed the CoDiC(®) database of the Japan Diabetes Data Management Study Group across 67 institutions in Japan. In a total of 3,698 drug-naïve patients who were initiated with metformin, dipeptidyl peptidase-4 inhibitor (DPP-4i) or sulfonylurea (SU) from 2007 to 2012, we evaluated body mass index (BMI) and hemoglobin A1c (HbA1c)...
May 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/24843596/present-status-of-insulin-therapy-for-type-2-diabetes-treated-by-general-practitioners-and-diabetes-specialists-in-japan-third-report-of-a-cross-sectional-survey-of-15-652-patients
#2
Keiko Arai, Masahiko Takai, Koichi Hirao, Ikuro Matsuba, Kiyokazu Matoba, Hiroshi Takeda, Akira Kanamori, Mikio Yamauchi, Hisao Mori, Yasuo Terauchi
UNLABELLED: Aims/Introduction:  Insulin therapy is often required to achieve good glycemic control in patients with type 2 diabetes mellitus. However, some providers, particularly general practitioners (GPs), are reluctant to prescribe insulin to their patients. The aim of the present study was to clarify any differences in, as well as any problems associated with, insulin therapy in patients with type 2 diabetes being treated by either a GP or a diabetes specialist in Japan. MATERIALS AND METHODS:   Of 15,652 patients across 721 clinics and hospitals, 15,350 were diagnosed with type 2 diabetes (14,312 by GPs and 1038 by specialists)...
August 20, 2012: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/24528246/both-glimepiride-and-high-dose-metformin-are-important-for-sustained-glucose-lowering-in-japanese-type-2-diabetes-patients-on-glimepiride-sitagliptin-metformin-therapy-subanalysis-of-a-single-center-open-label-randomized-study
#3
RANDOMIZED CONTROLLED TRIAL
Keiko Arai, Hajime Maeda, Shin-ichiro Shirabe, Ritsuko Yamamoto, Atsushi Kumakura, Mikio Yamauchi, Tetsuyuki Hirao, Setsuko Hirao, Koichi Hirao
BACKGROUND: In a previous single-center, open-label randomized 3-month study of triple oral antidiabetes drug (OAD) therapy, we investigated factors affecting the glycemic control afforded by sitagliptin, high-dose metformin, and low-dose glimepiride. Patients were prospectively assigned to either Group 1 (50% reduction in metformin) or Group 2 (discontinuation of glimepiride) and compared. The results showed that the glycated hemoglobin (HbA1c) levels of patients in Group 2 deteriorated more than those in Group 1, whereas HbA1c levels were maintained in some patients in both groups...
July 2014: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/23946679/combination-therapy-with-a-dipeptidyl-peptidase-4-inhibitor-sulfonylurea-and-metformin-markedly-improves-hba1c-levels-in-japanese-patients-with-type-2-diabetes-mellitus
#4
Koichi Hirao, Hajime Maeda, Shin-Ichiro Shirabe, Ritsuko Yamamoto, Tetsuyuki Hirao, Setsuko Hirao, Mikio Yamauchi, Keiko Arai
Combination therapy with a dipeptidyl peptidase (DPP)-4 inhibitor and metformin or sulfonylurea results in substantial and additive glucose-lowering effects in patients with type 2 diabetes mellitus (T2DM). However, it is not known whether triple combination therapy with a DPP-4 inhibitor, metformin, and sulfonylurea has greater additive effects or synergic effects. In the present report, we investigated the effect of addition of sitagliptin, the first-in-class DPP-4 inhibitor, to ongoing metformin and sulfonylurea therapy in three female Japanese patients with T2DM who refused insulin therapy...
2012: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/23480592/glimepiride-strongly-enhances-the-glucose-lowering-effect-in-triple-oral-antidiabetes-therapy-with-sitagliptin-and-metformin-for-japanese-patients-with-type-2-diabetes-mellitus
#5
RANDOMIZED CONTROLLED TRIAL
Keiko Arai, Hajime Maeda, Sin-ichiro Sirabe, Ritsuko Yamamoto, Mikio Yamauchi, Tetsuyuki Hirao, Setsuko Hirao, Koichi Hirao
BACKGROUND: After approval of sitagliptin and >750 mg of metformin in Japan, a triple oral antidiabetes drug (OAD) regimen including sulfonylurea, metformin, and sitagliptin was sometimes described. However, in the real world of clinical practice, the daily dose of sulfonylurea tended to be decreased according to the warning from the Japan Diabetes Society for avoiding hypoglycemia, instead of increasing the dose of metformin for maintaining hemoglobin A1c (HbA1c) levels with this regimen...
April 2013: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/23149657/short-duration-of-diabetes-and-disuse-of-sulfonylurea-have-any-association-with-insulin-cessation-of-the-patients-with-type-2-diabetes-in-a-clinical-setting-in-japan-jddm-30
#6
Keiko Arai, Koichi Hirao, Mikio Yamauchi, Masashi Kobayashi, Atsunori Kashiwagi
Insulin therapy is often required to achieve good glycemic control for the patients with type 2 diabetes mellitus (T2DM), while protraction of glycemic control without insulin therapy may be preferable for patients. To determine the characteristics of and therapeutic regimen in outpatients with T2DM who were able to stop insulin therapy with satisfactory glycemic control in a real clinical practice setting in Japan by a case-control study. The present study was performed on 928 patients with T2DM who started insulin therapy in 2007...
2013: Endocrine Journal
https://www.readbyqxmd.com/read/20208396/present-status-of-sulfonylurea-treatment-for-type-2-diabetes-in-japan-second-report-of-a-cross-sectional-survey-of-15-652-patients
#7
Keiko Arai, Kiyokazu Matoba, Koich Hirao, Ikuro Matsuba, Masahiko Takai, Hiroshi Takeda, Akira Kanamori, Mikio Yamauchi, Hisao Mori, Yasuo Terauchi
Sulfonylureas are commonly used for the treatment of patients with type 2 diabetes mellitus (T2DM). However, some clinical concerns regarding their use have grown over the past decade. Thus, results of a previous Japan-wide cross-sectional survey of patients with type 2 diabetes mellitus (T2DM) were analyzed to determine the present status and problems associated with the use of sulfonylureas in the treatment of T2DM by general practitioners (GPs) and diabetes specialists. Of 15,652 patients across 721 clinics and hospitals from the previous survey, 15,350 were diagnosed as T2DM (14,312 by GPs and 1,038 by specialists)...
2010: Endocrine Journal
https://www.readbyqxmd.com/read/19124170/the-status-of-glycemic-control-by-general-practitioners-and-specialists-for-diabetes-in-japan-a-cross-sectional-survey-of-15-652-patients-with-diabetes-mellitus
#8
MULTICENTER STUDY
Keiko Arai, Koich Hirao, Ikuro Matsuba, Masahiko Takai, Kiyokazu Matoba, Hiroshi Takeda, Akira Kanamori, Mikio Yamauchi, Hisao Mori, Yasuo Terauchi
To determine the status of diabetes care by general practitioners and diabetes specialists in Japan, we conducted a nation-wide cross-sectional survey. We asked 8112 clinics and hospitals randomly, from throughout Japan, to participate in this study and 721 facilities agreed. A total of 15,652 patients aged from 15 to 97 with type 1 and type 2 diabetes were enrolled. Of these, 14,560 (93.0%) and 1092 (7.0%) patients were cared for by general practitioners and diabetes specialists, respectively. HbA1c levels were measured by a latex agglutination method, and age, height, body weight, type of diabetes and treatment modality were obtained from each patient...
March 2009: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/18753706/association-between-body-mass-index-and-core-components-of-metabolic-syndrome-in-1486-patients-with-type-1-diabetes-mellitus-in-japan-jddm-13
#9
Keiko Arai, Hiroki Yokoyama, Fuminobu Okuguchi, Katsuya Yamazaki, Hirofumi Takagi, Koichi Hirao, Masashi Kobayashi et al.
There is no recent study on the prevalence of overweight and obesity in patients with type 1 diabetes mellitus (T1DM) in Japan. Being overweight has a significant effect on the metabolic condition and glycemic control of such patients. In the present cross-sectional study, we investigated the effects of body mass index (BMI) on lipid profile, blood pressure, and glycemic control in patients with T1DM. In total, 1486 patients with T1DM (including 401 patients with early onset T1DM who were <20 years of age at diagnosis) were included...
December 2008: Endocrine Journal
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