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https://www.readbyqxmd.com/read/29774522/genome-wide-compound-heterozygosity-analysis-highlighted-four-novel-susceptibility-loci-for-congenital-heart-disease-in-chinese-population
#1
T Jiang, M Huang, T Jiang, Y Gu, Y Wang, Y Wu, H Ma, G Jin, J Dai, Z Hu
Genome-wide association studies (GWASs) have achieved great success in deciphering the genetic cause of congenital heart disease (CHD). However, the heritability of CHD remains to be clarified, and numerous genetic factors responsible for occurrence of CHD are yet unclear. In this study, we performed a genome-wide search for relaxed forms of compound heterozygosity (CH) in association with CHD using our existing GWAS data including 2,265 individuals (957 CHD cases and 1,308 controls). CollapsABEL was used to iteratively test the association between the CH genotype and CHD phenotype in a sliding window manner...
May 17, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29769742/modified-citrus-pectin-inhibited-bladder-tumor-growth-through-downregulation-of-galectin-3
#2
Tian Fang, Dan-Dan Liu, He-Ming Ning, Dan Liu, Jing-Ya Sun, Xiao-Jing Huang, Yu Dong, Mei-Yu Geng, Shi-Feng Yun, Jun Yan, Rui-Min Huang
Modified citrus pectin (MCP) is a carbohydrate enriched complex, which has been implicated in cancer treatment and prevention. However, the effects of MCP on urinary bladder cancer (UBC) are unknown. In this study, MCP was first tested in T24 and J82 human UBC cells and showed the inhibition of cell viability by the sulforhodamine B (SRB) assay. The MCP-treated UBC cells exhibited G2 /M phase arrest with the decrease of Cyclin B1 and phosphorylated Cdc2. Caspase-3 was also activated, leading to the cleavage of Caspase-3 and PARP...
May 16, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29757976/fatty-acid-%C3%AE-oxidation-is-essential-in-leptin-mediated-oocytes-maturation-of-yellow-catfish-pelteobagrus-fulvidraco
#3
Yu-Feng Song, Xiao-Ying Tan, Ya-Xiong Pan, Li-Han Zhang, Qi-Liang Chen
Although several studies have been conducted to study leptin function, information is very scarce on the molecular mechanism of leptin in fatty acid β-oxidation and oocytes maturation in fish. In this study, we investigated the potential role of fatty acid β-oxidation in leptin-mediated oocytes maturation in Pelteobagrus fulvidraco . Exp. 1 investigated the transcriptomic profiles of ovary and the differential expression of genes involved in β-oxidation and oocytes maturation following rt-hLEP injection; rt-hLEP injection was associated with significant changes in the expression of genes, including twenty-five up-regulated genes ( CPT1 , Acsl , Acadl , Acadm , Hadhb , Echsl , Hsd17b4 , Acca , PPARα , CYP8B1 , ACOX1 , ACBP , MAPK , RINGO , Cdc2 , MEK1 , IGF-1R , APC/C, Cdk2 , GnRHR, STAG3 , SMC1 , FSHβ and C-Myc ) and ten down-regulated gene ( PPARγ , FATCD36 , UBC , PDK1 , Acads , Raf , Fizzy , C3H-4 , Raf and PKC ), involved in fatty acid β-oxidation and oocytes maturation...
May 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29746173/induction-of-gut-proteasome-activity-in-hemorrhagic-shock-and-its-recovery-by-treatment-with-diphenyldihaloketones-clefma-and-ef24
#4
Geeta Rao, Hailey Houson, Gregory Nkepang, Hooman Yari, Chengwen Teng, Vibhudutta Awasthi
BACKGROUND: Multi-organ failure in hemorrhagic shock is triggered by gut barrier dysfunction and consequent systemic infiltration of proinflammatory factors. Our previous study has shown that diphenyldihaloketone drugs CLEFMA and EF24 restore gut barrier dysfunction and reduce systemic inflammatory response in hemorrhagic shock. AIMS: We investigated the effect of hemorrhagic shock on proteasome activity of intestinal epithelium and how CLEFMA and EF24 treatments modulate proteasome function in hemorrhagic shock...
May 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29724585/urothelial-carcinoma-in-children-a-case-series
#5
Federica Marinoni, Francesca Destro, Giorgio Giuseppe Orlando Selvaggio, Giovanna Riccipetitoni
OBJECTIVE: To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria. MATERIALS AND METHODS: After obtaining ethical and legal authorization, we performed a restrospective monocentric study. We collected information of patients with UBC over a period of 10 years. We recorded: age, sex, reason for presentation, familial history and risk factors, preoperative assessment, surgical details, histological type and grade, follow-up...
April 30, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29721384/low-dose-gemcitabine-increases-the-cytotoxicity-of-human-v%C3%AE-9v%C3%AE-2-t-cells-in-bladder-cancer-cells-in-vitro-and-in-an-orthotopic-xenograft-model
#6
Teruki Shimizu, Mako Tomogane, Masatsugu Miyashita, Osamu Ukimura, Eishi Ashihara
Human γδT cell immunotherapy is well tolerated and has shown promising results in clinical trials; however, its antitumor efficacy is limited, including results in solid tumors. Ex-vivo expanded γδT cell stimulated by zoledronic acid (ZOL) activates the γδT cell subpopulation of so called Vγ9Vδ2 T cells. To improve the clinical outcomes of Vγ9Vδ2 T cell (abbreviated as γδT cell here) immunotherapy, we aimed to increase the cytotoxicity of γδT cells by focusing on two issues: recognition of tumor cells by γδT cells and the effector (γδT cell)-to-target (tumor cell) (E/T) ratio...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29693103/wheat-bran-with-enriched-gamma-aminobutyric-acid-attenuates-glucose-intolerance-and-hyperinsulinemia-induced-by-a-high-fat-diet
#7
Wenting Shang, Xu Si, Zhongkai Zhou, Padraig Strappe, Chris Blanchard
In this study, the level of gamma-aminobutyric acid (GABA) in wheat bran was increased to be six times higher through the action of endogenous glutamate decarboxylase compared with untreated bran. The process of GABA formation in wheat bran also led to an increased level of phenolic compounds with enhanced antioxidant capacity 2 times higher than the untreated status. The interventional effect of a diet containing GABA-enriched bran on hyperinsulinemia induced by a high-fat diet (HFD) was investigated in a rat model...
April 25, 2018: Food & Function
https://www.readbyqxmd.com/read/29688964/comparison-of-three-surgical-treatment-options-for-unicameral-bone-cysts-in-humerus
#8
Blaž Mavčič, Vinay Saraph, Magdalena M Gilg, Marko Bergovec, Janez Brecelj, Andreas Leithner
Treatment of unicameral bone cysts (UBC) in the humerus with drainage screws is scarcely reported in the literature. The aim of this retrospective study was to compare drainage screws and alternative treatment methods with respect to the number of required surgical procedures to achieve sufficient UBC healing, postoperative fractures/recurrences/complications, and radiological outcome. Medical archives of two tertiary orthopedic referral centers were screened for all patients who were treated surgically for humeral UBC in the period 1991-2015 with a histologically/cytologically confirmed diagnosis...
April 23, 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/29676191/treatment-according-to-guidelines-may-bridge-the-gender-gap-in-outcome-for-patients-with-stage-t1-urinary-bladder-cancer
#9
Carin Sjöström, Andreas Thorstenson, Viveka Ströck, Abolfazl Hosseini-Aliabad, Firas Aljabery, Fredrik Liedberg, Amir Sherif, Per-Uno Malmström, Johan Rosell, Truls Gårdmark, Staffan Jahnson
OBJECTIVE: The aim of this investigation was to study differences between male and female patients with stage T1 urinary bladder cancer (UBC) regarding intravesical instillation therapy, second resection and survival. MATERIALS AND METHODS: This study included all patients with non-metastatic primary T1 UBC reported to the Swedish National Register of Urinary Bladder Cancer (SNRUBC) from 1997 to 2014, excluding those treated with primary cystectomy. Differences between groups were evaluated using chi-squared tests and logistic regression, and survival was investigated using Kaplan-Meier and log-rank tests and Cox proportional hazards analysis...
April 20, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29674936/the-man%C3%A3%C2%BA-gradient-as-a-study-system-for-bird-pollination
#10
Mannfred Ma Boehm, Micah N Scholer, Jeremiah Jc Kennedy, Julian M Heavyside, Aniceto Daza, David Guevara-Apaza, Jill E Jankowski
Background: This study establishes an altiudinal gradient, spanning from the highland Andes (2400 m) to lowland Amazon, as a productive region for the study of bird pollination in Southeastern Peru. The 'Manú Gradient' has a rich history of ornithological research, the published data and resources from which lay the groundwork for analyses of plant-bird interactions. In this preliminary expedition we documented 44 plants exhibting aspects of the bird pollination syndrome, and made field observations of hummingbird visits at three sites spanning the Manú Gradient: 2800 m (Wayqecha), 1400 m (San Pedro), and 400 m (Pantiacolla)...
2018: Biodiversity Data Journal
https://www.readbyqxmd.com/read/29656391/proteomic-analysis-of-sperm-proteins-in-infertile-men-with-high-levels-of-reactive-oxygen-species
#11
A Ayaz, A Agarwal, R Sharma, N Kothandaraman, Z Cakar, S Sikka
Oxidative stress is a significant risk factor for male infertility. A pro-oxidant testicular environment may alter the expression profile of functional sperm proteins and result in poor sperm quality. Patients and donors were divided into ROS (-) and ROS (+) groups. Using computational studies, and data mining of available literature on spermatozoa, oxidative stress and proteomics, we identified three core regulatory proteins angiotensin-converting enzyme (ACE), heat-shock protein (Hsp70) family A member 2 (HSPA2) and ribosomal protein subunit 27A (RPS27A) and seven interlink proteins NOS2, SUMO2, UBL4A, FBXO25, MAP3K3, APP and UBC...
April 15, 2018: Andrologia
https://www.readbyqxmd.com/read/29620998/breast-cancer-family-history-and-contralateral-breast-cancer-risk-in-young-women-an-update-from-the-women-s-environmental-cancer-and-radiation-epidemiology-study
#12
Anne S Reiner, Julia Sisti, Esther M John, Charles F Lynch, Jennifer D Brooks, Lene Mellemkjær, John D Boice, Julia A Knight, Patrick Concannon, Marinela Capanu, Marc Tischkowitz, Mark Robson, Xiaolin Liang, Meghan Woods, David V Conti, David Duggan, Roy Shore, Daniel O Stram, Duncan C Thomas, Kathleen E Malone, Leslie Bernstein, Jonine L Bernstein
Purpose The Women's Environmental Cancer and Radiation Epidemiology (WECARE) study demonstrated the importance of breast cancer family history on contralateral breast cancer (CBC) risk, even for noncarriers of deleterious BRCA1/2 mutations. With the completion of WECARE II, updated risk estimates are reported. Additional analyses that exclude women negative for deleterious mutations in ATM, CHEK2*1100delC, and PALB2 were performed. Patients and Methods The WECARE Study is a population-based case-control study that compared 1,521 CBC cases with 2,212 individually matched unilateral breast cancer (UBC) controls...
April 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29615077/spire-combining-sgi-110-with-cisplatin-and-gemcitabine-chemotherapy-for-solid-malignancies-including-bladder-cancer-study-protocol-for-a-phase-ib-randomised-iia-open-label-clinical-trial
#13
Simon Crabb, Sarah J Danson, James W F Catto, Cathy McDowell, James N Lowder, Joshua Caddy, Denise Dunkley, Jessica Rajaram, Deborah Ellis, Stephanie Hill, David Hathorn, Amy Whitehead, Mihalis Kalevras, Robert Huddart, Gareth Griffiths
BACKGROUND: Urothelial bladder cancer (UBC) accounts for 10,000 new diagnoses and 5000 deaths annually in the UK (Cancer Research UK, http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/bladder-cancer , Cancer Research UK, Accessed 26 Mar 2018). Cisplatin-based chemotherapy is standard of care therapy for UBC for both palliative first-line treatment of advanced/metastatic disease and radical neoadjuvant treatment of localised muscle invasive bladder cancer...
April 3, 2018: Trials
https://www.readbyqxmd.com/read/29603838/stem-cell-defect-in-ubc-gfp-mice-facilitates-engraftment-of-lymphoid-primed-hematopoietic-stem-cells
#14
Kateřina Faltusová, Katarína Szikszai, Martin Molík, Jana Linhartova, Petr Páral, Luděk Šefc, Filipp Savvulidi, Emanuel Nečas
Transgenic mice expressing green fluorescent protein (GFP) are useful in transplantation experiments. When we used UBC-GFP transgenic mice to study the availability of niches for transplanted hematopoietic stem and progenitor cells, the results were strikingly different from the corresponding experiments that used congenic mice polymorphic in the CD45 antigen. Analysis of these unexpected results revealed that the hematopoiesis of UBC-GFP mice was outcompeted by the hematopoiesis of wild-type (WT) mice. Importantly, UBC-GFP mice engrafted the transplanted bone marrow of WT mice without conditioning...
March 31, 2018: Stem Cells
https://www.readbyqxmd.com/read/29588320/urinary-bladder-cancer-tregs-suppress-mmp2-and-potentially-regulate-invasiveness
#15
Malin E Winerdal, David Krantz, Ciputra A Hartana, Ali A Zirakzadeh, Ludvig Linton, Emma A Bergman, Robert Rosenblatt, Janos Vasko, Farhood Alamdari, Johan Hansson, Benny Holmström, Markus Johansson, Max Winerdal, Per Marits, Amir Sherif, Ola Winqvist
Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of Tregs on certain malignancies, including urinary bladder cancer (UBC). This discrepancy has partly been attributed to the shear misidentification of Tregs, but also to the inflammatory profile of the tumor. Our aim was to determine whether tumor-infiltrating Forkhead box P3+ (FOXP3+ ) cells confer a stable Treg phenotype and to investigate putative beneficial Treg functions, focusing on tumor-promoting inflammatory pathways in UBC...
March 27, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29570711/smoking-intensity-and-bladder-cancer-aggressiveness-at-diagnosis
#16
André L A Barbosa, Sita H H M Vermeulen, Katja K Aben, Anne J Grotenhuis, Alina Vrieling, Lambertus A Kiemeney
OBJECTIVE: To explore the relation between cigarette smoking intensity and bladder cancer aggressiveness at first diagnosis. METHODS: Patients diagnosed with urinary bladder cancer (BC) between 1995-2011 under the age of 75 years were retrospectively identified from the Netherlands Cancer Registry and invited for a study on genetic and lifestyle risk factors for BC. Information on patients' self-reported smoking history was retrieved by means of a postal questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29568567/key-genes-and-regulatory-networks-involved-in-the-initiation-progression-and-invasion-of-colorectal-cancer
#17
Matin Asghari, Mohammad Foad Abazari, Hanieh Bokharaei, Maryam Nouri Aleagha, Vahdat Poortahmasebi, Hassan Askari, Sepehr Torabinejad, Abbas Ardalan, Navid Negaresh, Atousa Ataei, Parisa Pazooki, Mansour Poorebrahim
Aim: Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC. Results: The results of gene expression profiles were integrated with protein-protein interaction networks, and topologically analyzed. The most important regulatory genes (e.g., CDK1 , UBC , ESR1 and ATXN1 ) and signaling pathways (e...
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29566946/high-cytoplasmic-hur-expression-is-associated-with-advanced-pt-stage-high-grade-and-increased-microvessel-density-in-urothelial-bladder-carcinoma
#18
Łukasz Piotr Fus, Paweł Pihowicz, Łukasz Koperski, Janina Maja Marczewska, Barbara Górnicka
PURPOSE: HuR (human antigen R) protein is a RNA binding protein that stabilizes the mRNA and controls the translation of genes involved in cell proliferation, differentiation, and carcinogenesis. Overexpression of HuR was reported in a variety of cancers, however its clinical significance in urothelial bladder cancer (UBC) is still unknown. Our aim is to investigate the association between HuR expression and selected histopathological factors, such as tumor grade, pT stage, regional lymph nodes status and microvessel density (MVD)...
April 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29566728/the-association-of-mammographic-density-with-risk-of-contralateral-breast-cancer-and-change-in-density-with-treatment-in-the-wecare-study
#19
Julia A Knight, Kristina M Blackmore, Jing Fan, Kathleen E Malone, Esther M John, Charles F Lynch, Celine M Vachon, Leslie Bernstein, Jennifer D Brooks, Anne S Reiner, Xiaolin Liang, Meghan Woods, Jonine L Bernstein
BACKGROUND: Mammographic density (MD) is an established predictor of risk of a first breast cancer, but the relationship of MD to contralateral breast cancer (CBC) risk is not clear, including the roles of age, mammogram timing, and change with treatment. Multivariable prediction models for CBC risk are needed and MD could contribute to these. METHODS: We conducted a case-control study of MD and CBC risk in phase II of the WECARE study where cases had a CBC diagnosed ≥ 2 years after first diagnosis at age <55 years and controls had unilateral breast cancer (UBC) with similar follow-up time...
March 22, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29565277/a-stratified-meta-analysis-of-the-association-between-exposure-to-environmental-tobacco-smoke-during-childhood-and-adulthood-and-urothelial-bladder-cancer-risk
#20
Frits H M van Osch, Sylvia H J Jochems, Anke Wesselius, Frederik J van Schooten, Richard T Bryan, Maurice P Zeegers
Background : Active smoking is a major risk factor for urothelial bladder cancer (UBC). However, the evidence that exposure to environmental tobacco smoke (ETS) either in childhood or adult life is also associated with UBC risk is ambiguous. With this meta-analysis, we aim to summarise how exposure to ETS is associated with UBC risk. Methods : In total, 11 studies (3 cohort studies, 8 case-control studies) were included in this meta-analysis and summary odds ratios (SORs) for UBC risk were calculated for never smokers who were exposed to ETS during childhood at home, during adulthood at home, or during adulthood in a work environment compared to never smokers who were never exposed to ETS...
March 22, 2018: International Journal of Environmental Research and Public Health
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