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https://www.readbyqxmd.com/read/28195645/exploring-the-views-of-relatives-of-frail-elderly-patients-about-participating-in-a-geriatric-dentistry-program
#1
Diego Machado Ardenghi, Chris Wyatt
Elderly residents of long-term care facilities (LTC) have difficulty accessing dental services. Aiming to improve access for this population, the Geriatric Dental Program (GDP) was established by UBC Faculty of Dentistry in 2002. Within the GDP, elderly people receive fee-for-service dental care. The objective of this research was to explore whether accessing these services had an impact on the lives of the patients' relatives. Data was collected through semi-structured, face-to-face, audio-recorded interviews with family members of 12 GDP patients...
February 14, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28188042/molecular-finds-of-pressure-ulcer-a-bioinformatics-approach-in-pressure-ulcer
#2
Eloa Mangabeira Santos, Lucyana Conceição Farias, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista de Paula, Carla Silvana de Oliveira E Silva, André Luiz Sena Guimarães
BACKGROUND: Understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. OBJECTIVE: This study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics. METHODS: We performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation...
January 28, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28185899/lurasidone-versus-treatment-as-usual-for-cognitive-impairment-in-euthymic-patients-with-bipolar-i-disorder-a-randomised-open-label-pilot-study
#3
Lakshmi N Yatham, Sylvia Mackala, Jayasree Basivireddy, Sharon Ahn, Nazlin Walji, Chen Hu, Raymond W Lam, Ivan J Torres
BACKGROUND: Cognitive impairment is present in euthymic patients with bipolar disorder and correlates with impairments in everyday functioning. We aimed to examine the efficacy of lurasidone adjunctive therapy compared with treatment as usual (TAU) in improving cognition. METHODS: For this randomised, open-label, pilot study, we recruited patients aged 19-65 years with euthymic bipolar I disorder from the Mood Disorder Centre in UBC Hospital (Vancouver, Canada)...
February 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28152941/transforming-a-unit-s-culture-to-improve-clinical-outcomes
#4
Theresa Woodrum, Michael Romano
: 243 Background: Leadership identified an unhealthy work environment existed in our Oncology Hematology Special Care Unit (OHSCU). This was evidenced by increased turnover, low National Database of Nursing Quality Indicators (NDNQI), and nurse sensitive quality indicator scores. In the fall of 2014 changes were made to the unit with a goal of creating within the unit a culture of clinical excellence, engagement, professionalism, accountability, and improve staff satisfaction. METHODS: Leadership met to define the future state of the unit and develop a vision statement...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152805/a-multidisciplinary-team-approach-to-efficient-breast-cancer-diagnosis
#5
Melissa Shelby, Shefali Birdi, Stephanie Costa Byrum, Julie Annie Yee Billar, Kevin McCabe, Jignesh Patel, Vilert A Loving
: 88 Background: System inefficiencies result in delayed breast cancer diagnoses. Inefficiencies include any non-value added steps between symptom onset/imaging abnormality to cancer diagnosis and treatment. Diagnostic delays can lead to more advanced disease and may negatively impact survival. Further, optimizing the efficiency of diagnostic evaluation models can reduce barriers to care and improve patient satisfaction. To achieve these efficiency goals, Banner MD Anderson Cancer Center (BMDACC) instituted the Undiagnosed Breast Clinic (UBC)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152021/identification-of-calgranulin-b-interacting-proteins-and-network-analysis-in-gastrointestinal-cancer-cells
#6
Kyung-Hee Kim, Seung-Gu Yeo, Byong Chul Yoo, Jae Kyung Myung
Calgranulin B is known to be involved in tumor development, but the underlying molecular mechanism is not clear. To gain insight into possible roles of calgranulin B, we screened for calgranulin B-interacting molecules in the SNU-484 gastric cancer and the SNU-81 colon cancer cells. Calgranulin B-interacting partners were identified by yeast two-hybrid and functional information was obtained by computational analysis. Most of the calgranulin B-interacting partners were involved in metabolic and cellular processes, and found to have molecular function of binding and catalytic activities...
2017: PloS One
https://www.readbyqxmd.com/read/28150815/gestational-weight-gain-and-fetal-maternal-adiponectin-leptin-and-crp-results-of-two-birth-cohorts-studies
#7
Chad A Logan, Rebecca Bornemann, Wolfgang Koenig, Frank Reister, Viola Walter, Giamila Fantuzzi, Maria Weyermann, Hermann Brenner, Jon Genuneit, Dietrich Rothenbacher
Gestational weight gain (GWG) is an important modifiable factor known to influence fetal outcomes including birth weight and adiposity. Unlike behaviors such as smoking and alcohol consumption, the effect of GWG throughout pregnancy on fetal development and other outcomes has not been extensively studied. The aim of this study was to investigate the relationship of GWG with endocrine factors such as adiponectin, leptin, and C-reactive protein which may be associated with inflammatory response, fetal growth, and adiposity later in life...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28149932/aquaporin-3-expression-loss-in-urothelial-carcinoma-association-with-tumor-invasion-depth-but-not-with-grading
#8
Johannes Breyer, Wolfgang Otto, Maximilian Burger, Arndt Hartmann, Peter C Rubenwolf
We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. Whereas former studies demonstrated that loss of AQP3 was associated with invasive and high-grade disease and worse progression-free and cancer-specific survival, this report investigates the expression of AQP3 in associated CIS. Contrary to what we had expected, all CIS specimens were shown to exhibit strong AQP3 expression, suggesting loss of AQP3 in UBC is primarily associated with the ability of tumor cells for invasion but not with grading as sign of dedifferentiation...
January 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28134789/mrpl10-and-tbp-are-suitable-reference-genes-for-peripheral-nerve-crush-injury
#9
Yaxian Wang, Qianqian Shan, Yali Meng, Jiacheng Pan, Sheng Yi
Peripheral nerve injury triggers the dysregulation of a large number of genes at multiple sites, including neurons, peripheral nerve stump, and the target organ. Housekeeping genes were frequently used as reference genes to normalize the expression values of target genes. Suitable selection of housekeeping genes that are stably expressed after nerve injury minimizes bias elicited by reference genes and thus helps to better and more sensitively reflect gene expression changes. However, many housekeeping genes have been used as reference genes without testing the expression patterns of themselves...
January 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28075205/a-genomic-and-protein-protein-interaction-analyses-of-nonsyndromic-hearing-impairment-in-cameroon-using-targeted-genomic-enrichment-and-massively-parallel-sequencing
#10
Kamogelo Lebeko, Noluthando Manyisa, Emile R Chimusa, Nicola Mulder, Collet Dandara, Ambroise Wonkam
Hearing impairment (HI) is one of the leading causes of disability in the world, impacting the social, economic, and psychological well-being of the affected individual. This is particularly true in sub-Saharan Africa, which carries one of the highest burdens of this condition. Despite this, there are limited data on the most prevalent genes or mutations that cause HI among sub-Saharan Africans. Next-generation technologies, such as targeted genomic enrichment and massively parallel sequencing, offer new promise in this context...
February 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28066890/undocumented-border-crosser-deaths-in-arizona-expanding-intrastate-collaborative-efforts-in-identification
#11
Julie M Fleischman, Ashley E Kendell, Christen C Eggers, Laura C Fulginiti
Undocumented Border Crosser (UBC) deaths in Arizona are a major issue faced by medicolegal authorities. Currently, the Maricopa County Office of the Medical Examiner (MCOME) is in possession of over two hundred unidentified individuals, more than half of whom are presumed to be UBCs. The primary goal of this study was to address the growing number of UBC deaths in Maricopa County in order to provide a more comprehensive picture of this important anthropological issue within the state of Arizona. Of the 107 total UBC cases evaluated for the study, the majority were male and age estimates for all individuals were between 15 to 60 years old...
January 9, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28063331/pcr-rates-in-patients-with-bilateral-breast-cancer-after-neoadjuvant-anthracycline-taxane-based-chemotherapy-a-retrospective-pooled-analysis-of-individual-patients-data-of-four-german-neoadjuvant-trials
#12
Mattea Reinisch, Jens Huober, Gunter von Minckwitz, Jens-Uwe Blohmer, Carsten Denkert, Claus Hanusch, Christian Jackisch, Sherko Kümmel, Andreas Schneeweiss, Kerstin Rhiem, Bianca Lederer, Michael Untch, Valentina Nekljudova V, Sibylle Loibl
PURPOSE: Patients with bilateral breast cancer (BBC) are usually excluded from participating in clinical trials and little is known about the response and outcome of BBC to neoadjuvant chemotherapy compared to unilateral BC (UBC). METHODS: We prospectively captured the information on patients with BBC in our database treated within four neoadjuvant chemotherapy trials and collected retrospectively the rate of pathological complete response (pCR) defined as ypT0 ypN0, ypT0/is ypN0, ypT0 ypNX, clinical and histologic parameters...
January 4, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28035618/who-1973-grade-3-and-infiltrative-growth-pattern-proved-aberrant-e-cadherin-expression-tends-to-be-of-predictive-value-for-progression-in-a-series-of-stage-t1-high-grade-bladder-cancer-after-organ-sparing-approach
#13
Wolfgang Otto, Johannes Breyer, Sonja Herdegen, Fabian Eder, Simone Bertz, Matthias May, Roman Mayr, Eva M Lausenmeyer, Stefan Denzinger, Bas W G van Rhijn, Maximilian Burger, Arndt Hartmann
PURPOSE: Stage pT1 urothelial bladder cancer (UBC) is characterized as a challenging subentity of urothelial carcinoma with an unforeseeable clinical course. In addition to more or less established clinical and histopathological features, we evaluated the role of epithelial-mesenchymal transition (EMT) marker E-cadherin, shown to be of prognostic value in muscle-invasive disease, regarding the prognosis of stage pT1 high-grade (hg) UBC. METHODS: Tissue of 226 stage pT1 hg UBC patients from transurethral resection could be immunostained for E-cadherin...
December 29, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/28034079/phase-iii-double-blind-randomized-trial-that-compared-maintenance-lapatinib-versus-placebo-after-first-line-chemotherapy-in-patients-with-human-epidermal-growth-factor-receptor-1-2-positive-metastatic-bladder-cancer
#14
Thomas Powles, Robert A Huddart, Tony Elliott, Shah-Jalal Sarker, Charlotte Ackerman, Robert Jones, Syed Hussain, Simon Crabb, Satinder Jagdev, John Chester, Serena Hilman, Mark Beresford, Graham Macdonald, Sundar Santhanam, John A Frew, Andrew Stockdale, Simon Hughes, Daniel Berney, Simon Chowdhury
Purpose To establish whether maintenance lapatinib after first-line chemotherapy is beneficial in human epidermal growth factor receptor (HER) 1/HER2-positive metastatic urothelial bladder cancer (UBC). Methods Patients with metastatic UBC were screened centrally for HER1/HER2 overexpression. Patients who screened positive for HER1/2 and who did not have progressive disease during chemotherapy (four to eight cycles) were randomly assigned one to one to lapatinib or placebo after completion of first-line/initial chemotherapy for metastatic disease...
January 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27992593/selection-and-validation-of-reference-genes-for-gene-expression-analysis-in-vigna-angularis-using-quantitative-real-time-rt-pcr
#15
Chao Chi, Yongqiang Shen, Lihua Yin, Xiwang Ke, Dong Han, Yuhu Zuo
Adzuki bean (Vigna angularis) is one of the most important legume crops in Asian countries like China, Japan and Korea due to its nutritious protein and starch contents. In spite of its economic importance, gene expression analysis system for gene function verification of adzuki bean is still absent. Therefore, reference genes for gene expression analysis based on the quantitative real time PCR (qRT-PCR) were screened in current study. A total of nine general housekeeping genes, including ACT, Fbox, ZMPP, GAPDH, EF, PP2A, UBC, UBN and PTB were evaluated for their expression stability by qRT-PCR in four adzuki bean cultivars, three different tissues, four abiotic stress and one biotic stress...
2016: PloS One
https://www.readbyqxmd.com/read/27956081/gene-markers-of-fracture-healing-in-early-stage-and-the-regulatory-mechanism-during-the-process-using-microarray-analysis
#16
Chengxue Wang, Baochang Qi, Lei Tan, Jieping Cheng
BACKGROUND: The aim of this study was to explore crucial markers and uncover the regulatory mechanisms of fracture healing in the early stage. METHODS: Gene expression profile of GSE45156 was downloaded, in which 3 fractured samples and 3 unfractured samples were used in our present study. Based on the threshold value, differentially expressed genes (DEGs) were selected between two kinds of samples using limma package in R. Enrichment analysis of these DEGs was performed by DAVID software...
December 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27913415/a-highly-expressed-high-molecular-weight-s-layer-complex-of-pelosinus-sp-strain-ufo1-binds-uranium
#17
Michael P Thorgersen, W Andrew Lancaster, Lara Rajeev, Xiaoxuan Ge, Brian J Vaccaro, Farris L Poole, Adam P Arkin, Aindrila Mukhopadhyay, Michael W W Adams
: Cell suspensions of Pelosinus sp. strain UFO1 were previously shown, using spectroscopic analysis, to sequester uranium as U(IV) complexed with carboxyl and phosphoryl group ligands on proteins. The goal of our present study was to characterize the proteins involved in uranium binding. Virtually all of the uranium in UFO1 cells was associated with a heterodimeric protein, which was termed the uranium-binding complex (UBC). The UBC was composed of two S-layer domain proteins encoded by UFO1_4202 and UFO1_4203...
February 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27883251/mir-892a-promotes-hepatocellular-carcinoma-cells-proliferation-and-invasion-through-targeting-cd226
#18
Baoxing Jia, Ludong Tan, Zhe Jin, Yan Jiao, Yu Fu, Yahui Liu
Our study is aim to investigate the influence of miR-892a on proliferative and invasive activities of human hepatocellular carcinoma (HCC) cells through regulating CD226 expression. QRT-PCR was used to detect the expression levels of miR-892a and CD226 mRNA in HCC tissues and adjacent tissues or HCC cells and normal cells whereas Western Blot was used to detect the CD226 protein expression in tissue and cell samples. Then HuH-7 cell line was selected for following assays and respectively transfected with miR-892a mimics, miR-NC, Plenti-GIII-Ubc-CD226, and Plenti-GIII-Ubc followed by qRT-PCR assay to detect the miR-892a and CD226 expression...
November 24, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27878453/evaluation-of-stability-and-validation-of-reference-genes-for-rt-qpcr-expression-studies-in-rice-plants-under-water-deficit
#19
Priscila Ariane Auler, Letícia Carvalho Benitez, Marcelo Nogueira do Amaral, Isabel Lopes Vighi, Gabriela Dos Santos Rodrigues, Luciano Carlos da Maia, Eugenia Jacira Bolacel Braga
Many studies use strategies that allow for the identification of a large number of genes expressed in response to different stress conditions to which the plant is subjected throughout its cycle. In order to obtain accurate and reliable results in gene expression studies, it is necessary to use reference genes, which must have uniform expression in the majority of cells in the organism studied. RNA isolation of leaves and expression analysis in real-time quantitative polymerase chain reaction (RT-qPCR) were carried out...
November 23, 2016: Journal of Applied Genetics
https://www.readbyqxmd.com/read/27849446/criticism-critique-and-opportunities-for-suicide-research-and-preventiona-review-of-critical-suicidology-transforming-suicide-research-and-prevention-for-the-21st-century-edited-by-jennifer-white-ian-marsh-michael-j-kral-and-jonathan-morris-vancouver-ubc-press
#20
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