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https://www.readbyqxmd.com/read/27883251/mir-892a-promotes-hepatocellular-carcinoma-cells-proliferation-and-invasion-through-targeting-cd226
#1
Baoxing Jia, Ludong Tan, Zhe Jin, Yan Jiao, Yu Fu, Yahui Liu
Our study is aim to investigate the influence of miR-892a on proliferative and invasive activities of human hepatocellular carcinoma (HCC) cells through regulating CD226 expression. QRT-PCR was used to detect the expression levels of miR-892a and CD226 mRNA in HCC tissues and adjacent tissues or HCC cells and normal cells whereas Western Blot was used to detect the CD226 protein expression in tissue and cell samples. Then HuH-7 cell line was selected for following assays and respectively transfected with miR-892a mimics, miR-NC, Plenti-GIII-Ubc-CD226, and Plenti-GIII-Ubc followed by qRT-PCR assay to detect the miR-892a and CD226 expression...
November 24, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27878453/evaluation-of-stability-and-validation-of-reference-genes-for-rt-qpcr-expression-studies-in-rice-plants-under-water-deficit
#2
Priscila Ariane Auler, Letícia Carvalho Benitez, Marcelo Nogueira do Amaral, Isabel Lopes Vighi, Gabriela Dos Santos Rodrigues, Luciano Carlos da Maia, Eugenia Jacira Bolacel Braga
Many studies use strategies that allow for the identification of a large number of genes expressed in response to different stress conditions to which the plant is subjected throughout its cycle. In order to obtain accurate and reliable results in gene expression studies, it is necessary to use reference genes, which must have uniform expression in the majority of cells in the organism studied. RNA isolation of leaves and expression analysis in real-time quantitative polymerase chain reaction (RT-qPCR) were carried out...
November 23, 2016: Journal of Applied Genetics
https://www.readbyqxmd.com/read/27849446/criticism-critique-and-opportunities-for-suicide-research-and-preventiona-review-of-critical-suicidology-transforming-suicide-research-and-prevention-for-the-21st-century-edited-by-jennifer-white-ian-marsh-michael-j-kral-and-jonathan-morris-vancouver-ubc-press
#3
https://www.readbyqxmd.com/read/27848898/proteomic-analysis-of-endothelin-1-targets-in-the-regulation-of-cardiomyocyte-proliferation
#4
Alexandra N Shin, Chiranjib Dasgupta, Lubo Zhang, Guangyu Zhang, Kala Seal
Hypoxia is a fetal stressor that leads to the production of endothelin-1 (ET-1). Previous work has shown that ET-1 treatment leads to the premature terminal differentiation of fetal cardiomyocytes. However, the precise mechanism is unknown. We tested the hypothesis that the fetal cardiomyocyte proteome will be greatly altered due to ET-1-treatment, which reveals a potential molecular mechanism of ET-1-induced terminal differentiation. Over a thousand proteins were detected in the fetal cardiomyocytes and among them 75 proteins were significantly altered due to ET-1 treatment...
November 16, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27836246/emerging-role-of-immunotherapy-in-urothelial-carcinoma-immunobiology-biomarkers
#5
REVIEW
Randy F Sweis, Matthew D Galsky
Urothelial bladder cancer is one of the first cancers recognized to be immunogenic since 40 years ago when the use of bacillus Calmette-Guerin was shown to prevent recurrence. Since that time, our knowledge of immune biology of cancer has expanded tremendously, and patients with bladder cancer finally have new active immunotherapeutic drugs on the horizon. Anti-programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) therapy has shown impressively durable responses in urothelial bladder cancer (UBC), but the reported response rates warrant improvement...
December 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27831648/a-personalized-approach-identifies-disturbed-pathways-and-key-genes-in-hepatitis-c-virus-cirrhosis-with-hepatocellular-carcinoma
#6
Y-G Li, M-X Zheng, G Wang
OBJECTIVE: This work aimed to identify disturbed pathways in hepatitis C virus (HCV)-cirrhosis with hepatocellular carcinoma (HCC) based on individualized pathway aberrance score (iPAS) method. MATERIALS AND METHODS: First of all, gene expression data and pathway data were recruited and preprocessed. Next, iPAS method, which contained three steps (gene-level statistics based on average Z algorithm, pathway-level statistics and pathway significant analysis based on Wilcoxon-test), was performed to identify differential pathways in HCV-cirrhosis with HCC...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27826948/validation-of-reference-genes-for-normalization-of-gene-expression-by-qrt-pcr-in-a-resveratrol-producing-entophytic-fungus-alternaria-sp-mg1
#7
Jin-Xin Che, Jun-Ling Shi, Yao Lu, Yan-Lin Liu
Alternaria sp. MG1, an endophytic fungus isolated from Vitis vinifera, can independently produce resveratrol, indicating that this species contains the key genes for resveratrol biosynthesis. Identification of these key genes is essential to understand the resveratrol biosynthesis pathway in this strain, which is currently unknown in microorganisms. qRT-PCR is an efficient and widely used method to identify the key genes related to unknown pathways at the level of gene expression. Verification of stable reference genes in this strain is essential for qRT-PCR data normalization, although results have been reported for other Alternaria sp...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27813596/genetic-variability-analysis-of-byrsonima-crassifolia-germplasm-collected-in-par%C3%A3-state-using-issr-markers
#8
S M Rodrigues, E F Moura, G K S Ramos, M S P Oliveira
Native of the Amazon, the nanche (Byrsonima crassifolia) is a fruit cultivated by family farmers and used in cooking; as such, it represents an opportunity for regional agribusiness. The Embrapa Eastern Amazon set up an active germplasm bank (BAG) consisting of 22 accessions sampled in 11 municipalities of Pará State. Due to its economic potential, there is an interest to advance the genetic breeding program of this species. The aim of this study was to characterize the BAG nanche collection using inter-simple sequence repeat (ISSR) markers...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27804056/smoking-status-usual-adult-occupation-and-risk-of-recurrent-urothelial-bladder-carcinoma-data-from-the-cancer-genome-atlas-tcga-project
#9
Amber N Wilcox, Debra T Silverman, Melissa C Friesen, Sarah J Locke, Daniel E Russ, Noorie Hyun, Joanne S Colt, Jonine D Figueroa, Nathaniel Rothman, Lee E Moore, Stella Koutros
PURPOSE: Tobacco smoking and occupational exposures are the leading risk factors for developing urothelial bladder carcinoma (UBC), yet little is known about the contribution of these two factors to risk of UBC recurrence. We evaluated whether smoking status and usual adult occupation are associated with time to UBC recurrence for 406 patients with muscle-invasive bladder cancer submitted to The Cancer Genome Atlas (TCGA) project. METHODS: Kaplan-Meier and Cox proportional hazard methods were used to assess the association between smoking status, employment in a high-risk occupation for bladder cancer, occupational diesel exhaust exposure, and 2010 Standard Occupational Classification group and time to UBC recurrence...
December 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27797436/radio-guided-sentinel-lymph-node-detection-and-lymph-node-mapping-in-invasive-urinary-bladder-cancer-a-prospective-clinical-study
#10
F Aljabery, I Shabo, Hans Olson, Oliver Gimm, Staffan Jahnson
OBJECTIVES: We investigated the possibility to detect sentinel nodes in patients with urinary bladder cancer (UBC) intra-operatively and whether the histopathological status of the identified sentinel nodes reflected that of the lymphatic field. PATIENTS AND METHODS: We studied 103 patients with UBC pathological stage T1-T4 who were treated with cystectomy and pelvic lymph node (LN) dissection during 2005-2011 at the Department of Urology, Linköping University Hospital...
October 31, 2016: BJU International
https://www.readbyqxmd.com/read/27785420/why-are-upper-tract-urothelial-carcinoma-two-different-diseases
#11
REVIEW
Tibor Szarvas, Orsolya Módos, András Horváth, Péter Nyirády
In the last few years growing evidence highlighted the differences between upper tract urothelial carcinoma (UTUC) and urothelial bladder carcinoma (UBC) which cannot be explained solely by their different anatomical location. The aim of this review was to summarize current progress in UTUC research and to underline the differences and similarities between UTUC and UBC by focusing on epidemiology, etiology, staging and risk factors as well as on surgical and medical management. UBC and UTUC sharing common risk factors such as smoking and aromatic amines, while aristolochic acid exposure or familiar Lynch syndrome are rather specific for UTUC...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27782819/erratum-to-the-ubc-40-urothelial-bladder-cancer-cell-line-index-a-genomic-resource-for-functional-studies
#12
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamín Rodríguez-Santiago, Marinela Méndez-Pertuz, Herbert Auer, Gonzalo Gómez, H Barton Grossman, David G Pisano, Wolfgang A Schulz, Luis A Pérez-Jurado, Alfredo Carrato, Dan Theodorescu, Stephen Chanock, Alfonso Valencia, Francisco X Real
No abstract text is available yet for this article.
October 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27765584/long-term-bladder-and-upper-urinary-tract-follow-up-recurrence-and-progression-rates-of-g1-2-non-muscle-invasive-urothelial-carcinoma-of-the-bladder
#13
Thomas Golabesk, Joan Palou, Oscar Rodriguez, Ruben Parada, Sergio Skrobot, José Antonio Peña, Humberto Villavicencio
OBJECTIVE: To evaluate the risk of long-term tumour recurrence and progression in patients with low- and intermediate-risk NMIBCs, which could facilitate optimisation in the follow-up schedules. PATIENTS AND METHODS: A single-institution, retrospective analysis of 704 patients with primary TaG1, TaG2, T1G1, and T1G2 urothelial carcinomas of the bladder (UBS) without concomitant carcinoma in situ (CIS), treated with transurethral resection (TUR) was performed. Response was determined and monitored by routine periodic urine cytology, cystoscopy, and upper tract imaging...
October 17, 2016: Urology
https://www.readbyqxmd.com/read/27761137/selection-of-reliable-reference-genes-for-gene-expression-analysis-under-abiotic-stresses-in-the-desert-biomass-willow-salix-psammophila
#14
Jianbo Li, Huixia Jia, Xiaojiao Han, Jin Zhang, Pei Sun, Mengzhu Lu, Jianjun Hu
Salix psammophila is a desert shrub willow that has extraordinary adaptation to abiotic stresses and plays an important role in maintaining local ecosystems. Moreover, S. psammophila is regarded as a promising biomass feedstock because of its high biomass yields and short rotation coppice cycle. However, few suitable reference genes (RGs) for quantitative real-time polymerase chain reaction (qRT-PCR) constrain the study on normalization of gene expression in S. psammophila until now. Here, we investigated the expression stabilities of 14 candidate RGs across tissue types and under four abiotic stress treatments, including heat, cold, salt, and drought treatments...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27756294/measuring-interprofessional-competencies-and-attitudes-among-health-professional-students-creating-family-planning-virtual-patient-cases
#15
Eric Wong, Jasmine J Leslie, Judith A Soon, Wendy V Norman
BACKGROUND: The Virtual Interprofessional Patients-Computer-Assisted Reproductive Health Education for Students (VIP-CARES) Project took place during the summers of 2010-2012 for eight weeks each year at the University of British Columbia (UBC). Undergraduate health care students worked collaboratively to develop virtual patient case-based learning modules on the topic of family planning. The purpose of this study was to evaluate the changes in perception towards interprofessional collaboration (IPC) among the participants, before and after the project...
October 19, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27746803/suitable-reference-genes-for-accurate-gene-expression-analysis-in-parsley-petroselinum-crispum-for-abiotic-stresses-and-hormone-stimuli
#16
Meng-Yao Li, Xiong Song, Feng Wang, Ai-Sheng Xiong
Parsley, one of the most important vegetables in the Apiaceae family, is widely used in the food, medicinal, and cosmetic industries. Recent studies on parsley mainly focus on its chemical composition, and further research involving the analysis of the plant's gene functions and expressions is required. qPCR is a powerful method for detecting very low quantities of target transcript levels and is widely used to study gene expression. To ensure the accuracy of results, a suitable reference gene is necessary for expression normalization...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27743995/withdrawn-selection-of-reference-genes-in-five-types-of-human-tissues-for-normalization-of-gene-expression-studies-in-infectious-diseases
#17
Cristina Silva Meira-Strejevitch, Vera Lucia Pereira-Chioccola, Marta Marques Maia, Daise Damaris Carnietto de Hipólito, Hui-Tzu Lin Wang, Gabriela Motoie, Aparecida Helena de Souza Gomes, Cristina Takami Kanamura, Roosecelis Brasil Martines, Cinara Cássia Brandão de Mattos, Fábio Batista Frederico, Luiz Carlos de Mattos, Cinara Cássia Brandão de Mattos, Fábio Batista Frederico, Rubens Camargo Siqueira, Mariana Previato, Amanda Pires Barbosa, Fernando Henrique Antunes Murata
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
October 12, 2016: Gene
https://www.readbyqxmd.com/read/27730700/multiple-rare-genetic-variants-co-segregating-with-familial-iga-nephropathy-all-act-within-a-single-immune-related-network
#18
S N Cox, F Pesce, J S El-Sayed Moustafa, F Sallustio, G Serino, C Kkoufou, A Giampetruzzi, N Ancona, M Falchi, F P Schena
BACKGROUND: IgA nephropathy (IgAN) is a common complex disease with a strong genetic involvement. We aimed to identify novel, rare, highly penetrant risk variants combining family-based linkage analysis with whole-exome sequencing (WES). METHODS: Linkage analysis of 16 kindreds of South Italian ancestry was performed using an 'affected-only' strategy. Eight most informative trios composed of two familial cases and an intrafamilial control were selected for WES. High-priority variants in linked regions were identified and validated using Sanger sequencing...
October 11, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27727313/endogenous-reference-genes-for-gene-expression-studies-on-bicuspid-aortic-valve-associated-aortopathy-in-humans
#19
Oliver J Harrison, Narain Moorjani, Christopher Torrens, Sunil K Ohri, Felino R Cagampang
Bicuspid aortic valve (BAV) disease is the most common congenital cardiac abnormality and predisposes patients to life-threatening aortic complications including aortic aneurysm. Quantitative real-time reverse transcription PCR (qRT-PCR) is one of the most commonly used methods to investigate underlying molecular mechanisms involved in aortopathy. The accuracy of the gene expression data is dependent on normalization by appropriate housekeeping (HK) genes, whose expression should remain constant regardless of aortic valve morphology, aortic diameter and other factors associated with aortopathy...
2016: PloS One
https://www.readbyqxmd.com/read/27713144/rgs6-is-an-essential-tumor-suppressor-that-prevents-bladder-carcinogenesis-by-promoting-p53-activation-and-dnmt1-downregulation
#20
Jianqi Yang, Lance T Platt, Biswanath Maity, Katelin E Ahlers, Zili Luo, Zhibo Lin, Bandana Chakravarti, Stella-Rita Ibeawuchi, Ryan W Askeland, Jolanta Bondaruk, Bogdan A Czerniak, Rory A Fisher
Urinary bladder cancer (UBC) is largely caused by exposure to toxic chemicals including those in cigarette smoke (i.e. BBN). An activating SNP in RGS6 is associated with a pronounced reduction in UBC risk, especially among smokers. However, the mechanism underlying this reduction remains unknown. Here we demonstrate that RGS6 is robustly expressed in human urothelium, where urothelial cell carcinoma originates, and is downregulated in human UBC. Utilizing RGS6-/- mice we interrogated a possible role for RGS6 as a tumor suppressor using the BBN-induced bladder carcinogenesis model that closely recapitulates human disease...
October 4, 2016: Oncotarget
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