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Spondylodiscitis pet

Ramin Mandegaran, Christopher S W Tang, Erlick A C Pereira, Ali Zavareh
OBJECTIVE: Very few reports have previously described spondylodiscitis as a potential complication of endovascular aortic aneurysm repair (EVAR). We present to our knowledge the first case series of spondylodiscitis following EVAR based on our institution's experience over an 11-year period. Particular attention is paid to the key imaging features and challenges encountered when performing spinal imaging in this complex patient group. MATERIALS AND METHODS: Of 1,847 patients who underwent EVAR at our institution between January 2006 and January 2017, a total of 9 patients were identified with imaging features of spondylodiscitis (0...
April 14, 2018: Skeletal Radiology
Mike M Sathekge, Alfred O Ankrah, Ismaheel Lawal, Mariza Vorster
Monitoring response to treatment is a key element in the management of infectious diseases, yet controversies still persist on reliable biomarkers for noninvasive response evaluation. Considering the limitations of invasiveness of most diagnostic procedures and the issue of expression heterogeneity of pathology, molecular imaging is better able to assay in vivo biologic processes noninvasively and quantitatively. The usefulness of 18 F-FDG-PET/CT in assessing treatment response in infectious diseases is more promising than for conventional imaging...
March 2018: Seminars in Nuclear Medicine
K Farah, T Graillon, H Dufour, S Fuentes
INTRODUCTION: Adjacent level spondylodiscitis (ALS) after primary surgery for thoracic spondylodiscitis is a very rare condition. CASE REPORT: We report the case of a 76-year-old man with this pathology. A first posterior minimally invasive approach combined with anterior approach to the thoracic spine was safely performed for thoracic spondylodiscitis. More than a year later, exploration of recurrent symptoms with 18 FDG PET scan helped to diagnose ALS. Further surgery was performed...
March 2018: Neuro-Chirurgie
Martina Sollini, Chiara Lauri, Roberto Boni, Elena Lazzeri, Paola Anna Erba, Alberto Signore
There is an increased need to find non-invasive tools for early diagnosis and follow-up of infections. Nuclear medicine techniques may be used to diagnose, localize and evaluate the severity and the extent of infections before the occurrence of anatomical abnormalities. This review focuses on different approaches based on radiolabelled cells, peptides and antibodies or [18F]FDG to image infective diseases in agreement with what is being jointly evaluated by the European Association of Nuclear Medicine (EANM)...
January 9, 2018: Current Pharmaceutical Design
Soile P Salomäki, Jukka Kemppainen, Ulla Hohenthal, Pauliina Luoto, Olli Eskola, Pirjo Nuutila, Marko Seppänen, Laura Pirilä, Jarmo Oksi, Anne Roivainen
Purpose: This study evaluated the potential of68 Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it with 2-[18 F]fluoro-2-deoxy- D -glucose (18 F-FDG) PET/CT. Methods: Four patients admitted to hospital due to S. aureus bacteraemia underwent both18 F-FDG and68 Ga-citrate whole-body PET/CT scans to detect infectious foci. Results: The time from hospital admission and the initiation of antibiotic treatment to the first PET/CT was 4-10 days...
2017: Contrast Media & Molecular Imaging
Matteo Bassetti, Maria Merelli, Fernando Di Gregorio, Paola Della Siega, Maria Screm, Claudio Scarparo, Elda Righi
BACKGROUND: Tuberculous spondylodiscitis can be difficult to diagnose because of its nonspecific symptoms and the similarities with non-tubercular forms of spinal infection. Fluorine-18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG PET-CT) is increasingly used for the diagnosis and monitoring of tubercular diseases. METHODS: Retrospective, case-control study comparing tuberculous spondylodiscitis with biopsy-confirmed pyogenic spondylodiscitis in the period 2010-2012...
June 2017: Skeletal Radiology
M Benucci, A Damiani, A Arena, M Infantino, M Manfredi, F Li Gobbi
We observed a 69-year old man suffering from HLA B27 ankylosing spondylitis with persistent night back pain. 18F-FDG-PET/CT showed an increased metabolism at the level of the spinal space of L2-L3, L3-L4 with increased uptake compatible with spondylodiscitis. He started therapy with etanercept 50 mg/week. After six months of treatment repeated testing showed no uptake of the discs and vertebral bodies.
December 16, 2016: Reumatismo
J R García
Fever of unknown origin is defined as a body temperature greater than 38.3°C lasting more than three weeks for which the cause could not be found within one week of hospital admission. More than 200 causes have been reported, and these can be classified into four categories: infections, inflammatory diseases, oncologic processes, and miscellaneous conditions. Noninvasive diagnostic techniques are used in 69.2% of cases and invasive techniques in 30.8%. Structural imaging techniques show the morphological changes from infectious, inflammatory, and tumor-related processes, but they do not allow the detection of the early changes brought about by these processes...
May 2017: Radiología
Christopher J Palestro
There are numerous imaging tests for diagnosing musculoskeletal infection. Radiographs are routinely performed, because even when not diagnostic, they provide an anatomic overview of the region of interest that could influence subsequent procedure selection and interpretation. MRI is sensitive and provides superb anatomic detail. Bone scintigraphy accurately diagnoses osteomyelitis in bones not affected by underlying conditions. (67)Ga is used primarily for spondylodiskitis. Although in vitro labeled leukocyte imaging is the radionuclide test of choice for complicating osteomyelitis such as diabetic pedal osteomyelitis and prosthetic joint infection, it is not useful for spondylodiskitis...
September 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Carolijn Smids, Ilse J E Kouijzer, Fidel J Vos, Tom Sprong, Allard J F Hosman, Jacky W J de Rooy, Erik H J G Aarntzen, Lioe-Fee de Geus-Oei, Wim J G Oyen, Chantal P Bleeker-Rovers
PURPOSE: The purpose of this study was to evaluate the diagnostic value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. METHODS: From January 2006 to August 2013 patients with a clinical suspicion of spondylodiscitis, with an infection, or with fever of unknown origin were retrospectively included if (18)F-FDG-PET/CT and MRI of the spine were performed within a 2-week time span...
February 2017: Infection
Jeanette Fahnert, Sandra Purz, Jan-Sven Jarvers, Christoph-Eckhard Heyde, Henryk Barthel, Patrick Stumpp, Thomas Kahn, Osama Sabri, Benjamin Friedrich
UNLABELLED: The diagnosis of spondylodiskitis is often challenging. MRI is quite sensitive but lacks specificity, and distinction from erosive osteochondritis is often difficult. We sought to assess the diagnostic value of (18)F-FDG PET combined with MRI (combined (18)F-FDG PET/MRI) in patients with suspected spondylodiskitis and an inconclusive clinical or MRI presentation. METHODS: In a prospective study, 30 patients with previous inconclusive MRI results and suspected spondylodiskitis underwent combined (18)F-FDG PET/MRI, including precontrast and postcontrast standard spine MRI sequences...
September 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Burcak Yilmaz Gunes, Cetin Onsel, Kerim Sonmezoglu, Resat Ozaras, Metin Halac, Fehmi Tabak, Sait Sager, Bilgul Mete, Haluk Sayman, Bedii Kanmaz
PURPOSE: In this retrospective study, we aimed to investigate the value of FDG-PET/CT in the diagnosis of spondylodiscitis (SD), the significance of dual time point imaging (DTPI) for SD diagnosis and the worth of SUVmax data for distinguishing tuberculous vs. non-tuberculous SD. MATERIALS AND METHODS: 32 patients with suspected SD were scanned with FDG-PET/CT. For quantitative analysis maximum standardized uptake value (SUVmax) of the lesion area was measured. Nineteen patients had DTPI of FDG-PET/CT...
July 2016: Diagnostic Microbiology and Infectious Disease
Marine Gaudé, Saison Julien, Frédéric Laurent, Tristan Ferry
No abstract text is available yet for this article.
March 25, 2016: BMJ Case Reports
Sana Amraoui, Ghoufrane Tlili, Manav Sohal, Benjamin Berte, Elif Hindié, Philippe Ritter, Sylvain Ploux, Arnaud Denis, Nicolas Derval, Christopher A Rinaldi, Charles Cazanave, Pierre Jais, Michel Haissaguerre, Laurence Bordenave, Pierre Bordachar
OBJECTIVES: The aim of this study was to investigate the role of 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scanning in identifying septic embolism in patients with lead endocarditis. BACKGROUND: Lead endocarditis may be associated with septic embolism, in which case the administration mode, type, and duration of antibiotic therapy must be adapted. However, diagnosis can be challenging: magnetic resonance imaging (MRI) cannot be performed in the vast majority of patients with cardiac implantable electronic devices (CIEDs)...
March 2016: JACC. Cardiovascular Imaging
Arnau Blasco-Lucas, José Luis Reyes-Juárez, María Nazarena Pizzi, Eduard Permanyer, Arturo Evangelista, Manuel Galiñanes
A 39-year-old female, active parenteral drug user was diagnosed of spondylodiscitis. A computed tomography (CT) scan showed an extensive aortic arch aneurysm. A positron emission tomography (PET)-CT scan, showing significant aortic wall uptake of the tracer through the whole aortic arch and the D8-D9 intervertebral disc, allowed us to suspect an aortitis despite negative blood cultures. The aneurysm was resected and reconstructed with 2 aortic homografts. Cultures of specimens from the aortic wall were positive to the fungi Scedosporium apiospermum...
June 2015: Annals of Thoracic Surgery
Maaike Blaauwgeers, Robin Hes
BACKGROUND: Bacteraemia caused by Staphylococcus aureus may result in metastatic infection sites. The most common types of metastatic infection are endocarditis and spondylodiscitis. Less common sites of infection can cause atypical symptoms and be a challenge to diagnose. CASE DESCRIPTION: A 23-year-old male presented at the Emergency Room with acute abdominal pain radiating to his groin area, abnormal gait and fever. Blood cultures showed S. aureus. Endocarditis was ruled out by transthoracic echocardiography...
2015: Nederlands Tijdschrift Voor Geneeskunde
Federico Mancini, Andrea Ascoli-Marchetti, Luca Garro, Roberto Caterini
Osteolytic vertebral erosion is usually related to tumours, spondylitis or spondylodiscitis. Few reports in the literature describe lytic lesions of anterior lumbar vertebral bodies resulting from abdominal aortic aneurysm or false aneurysm. We report a case of abdominal aortic false aneurysm that caused lytic lesions of the second and third vertebral bodies in an 80-year-old man who underwent endovascular aneurysm repair. Fluoroscopy guided biopsy excluded infection or tumour. We performed a posterior spinal fusion and decompression because of bone loss of the second and third lumbar vertebral bodies and central stenosis...
December 2014: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
R Ghermandi, A Mesfin, S Terzi, S Colangeli, E Zamparini, A Gasbarrini
Familial dysautomonia (FD, or Riley-Day syndrome) is a rare but fatal autosomal recessive peripheral neuropathy caused by a point mutation in I-κ-B kinase complex associated protein (IKBCAP) gene. The disease, that affects primarily people of Ashkenazi Jewish origin, prejudices the development of primary sensory neurons determining depletion of autonomic and sensory neurons. Musculoskeletal problems include: spinal deformities, foot deformities, fractures and arthopathies. In this article we review a case of a 34 years old male of non-Jewish origin affected by FD presenting L2-L3 kyphosis and inability to walk due to chronic L2-L3 spondylodiscitis not surgically treated 14 years before as acute disease...
2014: European Review for Medical and Pharmacological Sciences
P Jutte, E Lazzeri, L M Sconfienza, V Cassar-Pullicino, A Trampuz, N Petrosillo, A Signore
Infections of the bone, spine and prosthetic joints are serious and complex conditions to diagnose and to treat. Structured diagnostic workup may very well improve the accuracy and speed of diagnosis, thereby improving the outcome since treatment may very well be more successful and less harmful if timely management is started. Literature shows no uniform advise on diagnosis. The EANM organized a consensus meeting with representatives from the involved disciplines in order to develop common flowcharts for the diagnosis of osteomyelitis, spondylodiscitis and prosthetic joint infections...
March 2014: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Michael L Prodromou, Panayiotis D Ziakas, Loukia S Poulou, Petros Karsaliakos, Loukas Thanos, Eleftherios Mylonakis
PURPOSE: Spondylodiscitis is a rare infectious entity that requires multimodal diagnostic procedures. We evaluated the diagnostic performance of 18F-FDG PET on suspected spondylodiscitis based on published literature. PATIENTS AND METHODS: We searched the PubMed and EMBASE for pertinent studies up to July 2013. We implemented a patient-based meta-analysis of diagnostic data for FDG PET (the index test) against clinical, laboratory, and/or radiologic evidence of disease (the reference standard)...
April 2014: Clinical Nuclear Medicine
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