keyword
MENU ▼
Read by QxMD icon Read
search

Body homeostasis

keyword
https://www.readbyqxmd.com/read/29786653/role-for-cystathionine-%C3%AE-lyase-cse-in-an-ethanol-e-induced-lesion-in-fetal-brain-gsh-homeostasis
#1
Dhyanesh Patel, Marylatha Rathinam, Courtney Jarvis, Lenin Mahimainathan, George Henderson, Madhusudhanan Narasimhan
Earlier, we reported that gestational ethanol (E) can dysregulate neuron glutathione (GSH) homeostasis partially via impairing the EAAC1-mediated inward transport of Cysteine (Cys) and this can affect fetal brain development. In this study, we investigated if there is a role for the transulfuration pathway (TSP), a critical bio-synthetic point to supply Cys in E-induced dysregulation of GSH homeostasis. These studies utilized an in utero E binge model where the pregnant Sprague⁻Dawley (SD) rat dams received five doses of E at 3...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786575/spatial-organization-of-the-excretory-ducts-and-sections-of-microcirculatory-blood-flow-of-the-labial-salivary-glands-in-older-adults
#2
Volodymyr H Hryn, Tamara F Deineha, Аndrij V Piliuhin, Anna V Lavrenko, Dmytro O Lavrenko
OBJECTIVE: Introduction: Salivary glands have a significant impact on the state of the homeostasis of the human body, oral cavity in particular, sensitively responding to pathological processes. The reactivity of the salivary glands in response to pathological processes that are organically linked to morphology and functions of the organ's structures, and particularly the excretory ducts of the glands and their microcirculatory blood flow, is one of the problems which have not been solved to date...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29785472/the-impacts-of-gastroileostomy-rat-model-on-glucagon-like-peptide-1-a-promising-model-to-control-type-2-diabetes-mellitus
#3
Behrouz Keleidari, Rastin Mohammadi Mofrad, Shahab Shahabi Shahmiri, Mohammad Hossein Sanei, Mohsen Kolahdouzan, Erfan Sheikhbahaei
BACKGROUND: One of the new current treatment options for Diabetes Mellitus is about increasing glucagon-like peptide-1 (GLP-1) activity. GLP-1 with its incretin effect showed major role in glucose homeostasis. Gastroileostomy can increase GLP-1 secretion by rapid delivery of undigested food to the terminal ileum. We studied the early effects of a gastroileostomy on serum levels of GLP-1, glucose, and insulin in rats. METHODS: Gastroileostomies with side-to-side anastomosis were performed on 15 male New Zealand rats...
May 21, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29784876/chca-1-is-a-copper-regulated-ctr1-homolog-required-for-normal-development-copper-accumulation-and-copper-sensing-behavior-in-caenorhabditis-elegans
#4
Sai Yuan, Anuj Kumar Sharma, Alexandria Richart, Jaekwon Lee, Byung-Eun Kim
Copper (Cu) plays key roles in catalytic and regulatory biochemical reactions essential for normal growth, development, and health. Dietary Cu deficiencies or mutations in Cu homeostasis genes can lead to abnormal musculoskeletal development, cognitive disorders, and poor growth. In yeast and mammals, Cu is acquired through the activities of the Ctr1 family of high-affinity Cu transporters. However, the mechanisms of systemic responses to dietary or tissue-specific Cu deficiency remain unclear. Here, taking advantage of the animal model Caenorhabditis elegans for studying whole-body Cu homeostasis, we investigated the role of a C...
May 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29782483/magnolol-and-honokiol-attenuate-apoptosis-of-enterotoxigenic-escherichia-coli-induced-intestinal-epithelium-by-maintaining-secretion-and-absorption-homeostasis-and-protecting-mucosal-integrity
#5
Yanli Deng, Xuefeng Han, Shaoxun Tang, Chengjian Li, Wenjun Xiao, Zhiliang Tan
BACKGROUND The cortex of Magnolia officinalis has long been used as an element of traditional Chinese medicine for the treatment of anxiety, chronic bronchitis, and gastrointestinal dysfunction. This study aimed to elucidate the underlying mechanism of its functional ingredients (magnolol and honokiol) in modifying the secretion and absorption homeostasis and protecting mucosal integrity in an Enterotoxigenic Escherichia coli (ETEC)-induced diarrhea mouse model. MATERIAL AND METHODS This study established a diarrhea mouse model infected by ETEC at a dosage of 0...
May 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29781215/strap-deficiency-impairs-mouse-embryonic-stem-cells-lineage-commitment-through-cyp26a1-mediated-retinoic-acid-homeostasis
#6
Lin Jin, Chenbei Chang, Kevin M Pawlik, Arunima Datta, Larry M Johnson, Trung Vu, Joseph L Napoli, Pran K Datta
Retinoic acid (RA) signaling is essential for the differentiation of embryonic stem cells (ESCs) and vertebrate development. RA biosynthesis and metabolism are controlled by a series of enzymes, but the molecular regulators of these enzymes remain largely obscure. In this study, we investigated the functional role of the WD-domain protein STRAP (serine threonine kinase receptor-associated protein) in the pluripotency and lineage commitment of murine ESCs. We generated Strap knockout (KO) mouse ESCs and subjected them to spontaneous differentiation...
May 21, 2018: Stem Cells
https://www.readbyqxmd.com/read/29780857/multi-omic-network-based-interrogation-of-rat-liver-metabolism-following-gastric-bypass-surgery-featuring-swath-proteomics
#7
Gautham Vivek Sridharan, Matthew D'Alessandro, Shyam Sundhar Bale, Vicky Bhagat, Hugo Gagnon, John M Asara, Korkut Uygun, Martin L Yarmush, Nima Saeidi
Morbidly obese patients often elect for Roux-en-Y gastric bypass (RYGB), a form of bariatric surgery that triggers a remarkable 30% reduction in excess body weight and reversal of insulin resistance for those who are type II diabetic. A more complete understanding of the underlying molecular mechanisms that drive the complex metabolic reprogramming post-RYGB could lead to innovative non-invasive therapeutics that mimic the beneficial effects of the surgery, namely weight loss, achievement of glycemic control, or reversal of non-alcoholic steatohepatitis (NASH)...
September 2017: Technology
https://www.readbyqxmd.com/read/29780059/the-relationship-between-vitronectin-and-hepatic-insulin-resistance-in-type-2-diabetes-mellitus
#8
Yan Cao, Xinyu Li, Chong Lu, Xiaorong Zhan
The World Health Organization (WHO) estimates that approximately 300 million people will suffer from diabetes mellitus by 2025. Type 2 diabetes mellitus (T2DM) is much more prevalent. T2DM comprises approximately 90% of diabetes mellitus cases, and it is caused by a combination of insulin resistance and inadequate compensatory insulin secretory response. In this study, we aimed to compare the plasma vitronectin (VN) levels between patients with T2DM and insulin resistance (IR) and healthy controls. Seventy patients with IR and 70 age- and body mass index (BMI)-matched healthy controls were included in the study...
May 18, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29779472/effect-of-body-weight-on-metabolic-hormones-and-fatty-acid-metabolism-in-follicular-fluid-of-women-undergoing-in-vitro-fertilization-a-pilot-study
#9
Laurice Bou Nemer, Haolin Shi, Bruce Richard Carr, Ruth Ann Word, Orhan Bukulmez
INTRODUCTION: Obesity is an epidemic affecting more than one-third of adults in the United States. Obese women experience decreased fertility, explained in part by oocyte quality. Since follicular fluid (FF) provides an important microenvironment for oocyte growth, we sought to evaluate the effect of increased body weight on FF levels of 11 metabolic hormones and fatty acid metabolism. METHODS: The FF was collected from 25 women (10 normal weight, 10 overweight, and 5 obese) with diminished ovarian reserve undergoing in vitro fertilization (IVF) following a minimal stimulation protocol...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29777919/brain-to-bone-what-is-the-contribution-of-the-brain-to-skeletal-homeostasis
#10
REVIEW
Anna Idelevich, Roland Baron
The brain, which governs most, if not all, physiological functions in the body, from the complexities of cognition, learning and memory, to the regulation of basal body temperature, heart rate and breathing, has long been known to affect skeletal health. In particular, the hypothalamus - located at the base of the brain in close proximity to the medial eminence, where the blood-brain-barrier is not as tight as in other regions of the brain but rather "leaky", due to fenestrated capillaries - is exposed to a variety of circulating body cues, such as nutrients (glucose, fatty acids, amino acids), and hormones (insulin, glucagon, leptin, adiponectin) [1-3]...
May 16, 2018: Bone
https://www.readbyqxmd.com/read/29775672/upregulation-of-psmb8-and-cathepsins-in-the-human-brains-of-dementia-with-lewy-bodies
#11
Qunxing Ding, Haiyan Zhu
Proteasome and lysosome are responsible for the homeostasis of proteins, lipids and carbohydrates in cells. Numerous reports indicate the proteolytic pathways have altered functions during neurodegeneration and aging. Dementia with Lewy bodies (DLB) is one of the leading forms of dementia, and the proteolytic alteration in DLB has not yet been fully investigated. This study shows that the components of proteasome and lysosome had selectively altered gene expression and enzymatic functions. Specifically, PSMB8, an inducible proteasomal β subunit, had elevated mRNA level and protein level in DLB brain compared with age-matched controls...
May 16, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29775660/the-role-of-the-egfr-signaling-pathway-in-stem-cell-differentiation-during-planarian-regeneration-and-homeostasis
#12
REVIEW
Sara Barberán, Francesc Cebrià
Cell signaling is essential for cells to adequately respond to their environment. One of the most evolutionarily conserved signaling pathways is that of the epidermal growth factor receptor (EGFR). Transmembrane receptors with intracellular tyrosine kinase activity are activated by the binding of their corresponding ligands. This in turn activates a wide variety of intracellular cascades and induces the up- or downregulation of target genes, leading to a specific cellular response. Freshwater planarians are an excellent model in which to study the role of cell signaling in the context of stem-cell based regeneration...
May 15, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29773170/iron-and-innate-antimicrobial-immunity-depriving-the-pathogen-defending-the-host
#13
REVIEW
Manfred Nairz, Stefanie Dichtl, Andrea Schroll, David Haschka, Piotr Tymoszuk, Igor Theurl, Günter Weiss
The acute-phase response is triggered by the presence of infectious agents and danger signals which indicate hazards for the integrity of the mammalian body. One central feature of this response is the sequestration of iron into storage compartments including macrophages. This limits the availability of this essential nutrient for circulating pathogens, a host defence strategy known as 'nutritional immunity'. Iron metabolism and the immune response are intimately linked. In infections, the availability of iron affects both the efficacy of antimicrobial immune pathways and pathogen proliferation...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772389/hippocampal-microglia-modifications-in-c57bl-6-pah-enu2-and-btbr-pah-enu2-phenylketonuria-pku-mice-depend-on-the-genetic-background-irrespective-of-disturbed-sleep-patterns
#14
Els van der Goot, Vibeke M Bruinenberg, Femke M Hormann, Ulrich L M Eisel, Francjan J van Spronsen, Eddy A Van der Zee
Toxic levels of phenylalanine in blood and brain is a characteristic of (untreated) phenylketonuria (PKU), leading to cognitive deficits in PKU mice. In addition, our recent findings showed that PKU mice (as well as PKU patients) have a disturbed sleep/wake cycle. As a consequence, sleep loss may contribute to cognitive deficits in PKU. Sleep loss has been linked to increased activation of microglia in the hippocampus. In this study, we set out to examine morphological features of the microglia population in the hippocampus of the mouse PKU model, using both the C57Bl/6 and the BTBR strain and their wild-type controls (age 5...
May 14, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29772338/hyaluronic-acid-an-efficient-biomacromolecule-for-treatment-of-inflammatory-skin-and-joint-diseases-a-review-of-recent-developments-and-critical-appraisal-of-preclinical-and-clinical-investigations
#15
REVIEW
Li Hui Chen, Jian Feng Xue, Zhi Yong Zheng, Muhammad Shuhaidi, Hnin Ei Thu, Zahid Hussain
Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29771451/modulation-of-inflammatory-and-hormonal-parameters-in-response-to-testosterone-therapy-effects-on-the-ventral-prostate-of-adult-rats
#16
Leonardo O Mendes, Anthony C S Castilho, Cristiane F Pinho, Bianca F Gonçalvez, Eduardo M Razza, Luiz Gustavo A Chuffa, Janete A Anselmo-Franci, Wellerson R Scarano, Francisco E Martinez
Testosterone is often recommended in the treatment of several aging-related conditions. However, there are still questions about the consequences of this therapy in terms of hormonal and inflammatory parameters that are crucial for prostate homeostasis.Thus, we investigate if the testosterone therapy (TT) modulates the hormone receptors and inflammatory cytokines in the ventral prostate of adult rats. Wistar rats aging 150 days were divided into two experimental groups(n = 10/group): T: received subcutaneous injections of testosterone cypionate (5mg/kg body weight) diluted in corn oil every other day for 4 weeks; and C: received corn oil as vehicle...
May 17, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29771336/fto-is-a-transcriptional-repressor-to-auto-regulate-its-own-gene-and-potentially-associated-with-homeostasis-of-body-weight
#17
Shu-Jing Liu, Hui-Ling Tang, Qian He, Ping Lu, Tao Fu, Xu-Ling Xu, Tao Su, Mei-Mei Gao, Shumin Duan, Yan Luo, Yue-Sheng Long
Fat mass and obesity-associated (FTO) protein is a ferrous ion (Fe2+)/2-oxoglutarate (2-OG)-dependent demethylase preferentially catalyzing m6A sites in RNA. The FTO gene is highly expressed in the hypothalamus with fluctuation in response to various nutritional conditions, which is believed to be involved in the control of whole body metabolism. However, the underlying mechanism in response to different nutritional cues remains poorly understood. Here we show that ketogenic diet-derived ketone body β-hydroxybutyrate (BHB) transiently increases FTO expression in both mouse hypothalamus and cultured cells...
May 16, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29769092/mineralization-of-alpha-1-antitrypsin-inclusion-bodies-in-mmalton-alpha-1-antitrypsin-deficiency
#18
Francesco Callea, Isabella Giovannoni, Paola Francalanci, Renata Boldrini, Gavino Faa, Daniela Medicina, Valerio Nobili, Valeer J Desmet, Kamal Ishak, Kuniaki Seyama, Emanuele Bellacchio
BACKGROUND: Alpha-1-antitrypsin (AAT) deficiency (AATD) of Z, Mmalton, Siiyama type is associated with liver storage of the mutant proteins and liver disease. The Z variant can be diagnosed on isoelectric focusing (IEF) while Mmalton and Siiyama may be missed or misdiagnosed with this technique. Therefore, molecular analysis is mandatory for their characterization. In particular, that holds true for the Mmalton variant as on IEF profile it resembles the wild M2 subtype. METHODS: This is a retrospective analysis involving review of medical records and of liver biopsy specimens from a series of Mmalton, Z and Siiyama Alpha-1-antitrypsin deficiency patients...
May 16, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29768065/fibroblast-growth-factor-21-adiposity-and-macronutrient-balance-in-a-healthy-pregnant-population-with-overweight-and-obesity
#19
Elizabeth F Sutton, Christopher D Morrison, Jacqueline M Stephens, Leanne M Redman
AIM OF THE STUDY: The regulation and actions of fibroblast growth factor 21 (FGF21) are responsive to energy status and macronutrient balance, and investigations of FGF21 in normal pregnancy, which could be informative for FGF21 biology, are seldom. The goal of our study was to examine FGF21 levels in a contemporary healthy, pregnant population. METHODS: We phenotyped 43 women with overweight and obesity during pregnancy for weight, body composition, and fasting blood...
May 16, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29767680/propensity-for-adverse-pregnancy-outcomes-in-african-american-women-may-be-explained-by-low-energy-expenditure-in-early-pregnancy
#20
Jasper Most, L Anne Gilmore, Abby D Altazan, Marshall St Amant, Robbie A Beyl, Eric Ravussin, Leanne M Redman
Background: African-American (AA) women have poorer pregnancy outcomes and studies in nonpregnant women suggest a different etiology of weight gain in AA compared with white women. We hypothesized that physiologic factors such as low energy expenditure and physical activity would be present in AA compared with white women in pregnancy. Objective: We aimed to identify physiologic risk factors for disordered energy balance in AA and white women early in pregnancy...
May 14, 2018: American Journal of Clinical Nutrition
keyword
keyword
78705
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"