Nafisseh S Warner, Andrew C Hanson, Phillip J Schulte, Firat Kara, Robert I Reid, Christopher G Schwarz, Eduardo E Benarroch, Jonathan Graff-Radford, Prashanthi Vemuri, Clifford R Jack, Ronald C Petersen, David O Warner, Michelle M Mielke, Kejal Kantarci
OBJECTIVE: To evaluate the associations between prescription opioid exposures in community-dwelling older adults and gray and white matter structure by magnetic resonance imaging. METHODS: Secondary analysis was conducted of a prospective, longitudinal population-based cohort study employing cross-sectional imaging of older adult (≥65 years) enrollees between November 1, 2004, and December 31, 2017. Gray matter outcomes included cortical thickness in 41 structures and subcortical volumes in 6 structures...
May 2024: Mayo Clinic Proceedings