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https://www.readbyqxmd.com/read/28651412/-comparison-of-application-of-cochran-armitage-trend-test-and-linear-regression-analysis-for-rate-trend-analysis-in-epidemiology-study
#1
D Z Wang, C Wang, C F Shen, Y Zhang, H Zhang, G D Song, X D Xue, Z L Xu, S Zhang, G H Jiang
We described the time trend of acute myocardial infarction (AMI) from 1999 to 2013 in Tianjin incidence rate with Cochran-Armitage trend (CAT) test and linear regression analysis, and the results were compared. Based on actual population, CAT test had much stronger statistical power than linear regression analysis for both overall incidence trend and age specific incidence trend (Cochran-Armitage trend P value<linear regression P value). The statistical power of CAT test decreased, while the result of linear regression analysis remained the same when population size was reduced by 100 times and AMI incidence rate remained unchanged...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651400/-mobile-internet-based-survey-of-current-status-of-hiv-test-and-related-factors-in-men-who-have-sex-with-men-in-college-students-in-china
#2
Y Y Jin, J Xu, Z Jiang, Z Y Wu
Objective: To assess the current status of HIV test during the past year and related factors in men who have sex with men (MSM) in college students in China. Methods: Based on a MSM website, a cross-sectional study was conducted in 500 MSM in college students aged 18-25 years, who were selected based on the estimated HIV detection rate of 50% in this population, by means of mobile phone questionnaire survey. χ(2) test and non-conditional multivariate logistic regression analysis were conducted to identify the factors related with HIV test, respectively...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651357/using-viral-gene-sequences-to-compare-and-explain-the-heterogeneous-spatial-dynamics-of-virus-epidemics
#3
Simon Dellicour, Rebecca Rose, Nuno Rodrigues Faria, Luiz Fernando Pereira Vieira, Hervé Bourhy, Marius Gilbert, Philippe Lemey, Oliver G Pybus
Rabies is an important zoonotic disease distributed worldwide. A key question in rabies epidemiology is the identification of factors that impact virus dispersion. Here we apply new analytical methods, based on phylogeographic reconstructions of viral lineage movement, to undertake a comparative evolutionary-epidemiological study of the spatial dynamics of rabies virus (RABV) epidemics in different hosts and habitats. We have compiled RABV data sets from skunk, raccoon, bat and domestic dog populations in order to investigate the viral diffusivity of different RABV epidemics, and detect and compare those environmental factors that impact the velocity of viral spread in continuous spatial landscapes...
June 23, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28651310/clinicopathological-characteristics-of-extremely-young-korean-multiple-myeloma-patients-therapeutic-implications
#4
Junghoon Shin, Youngil Koh, Jeonghwan Youk, Miso Kim, Byung Soo Kim, Chul Won Choi, Hwa Jung Sung, Yong Park, Sung-Soo Yoon, Inho Kim
Background/Aims: Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population. Methods: We reviewed the medical records of MM patients whose age was 40 years or younger at diagnosis. Results: A total of 32 patients were analyzed (male to female ratio 19:13, median age 37 years). According to International Staging System, 29%, 48%, and 16% were in stage I, II, and III, respectively...
June 26, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28651309/the-pattern-of-choosing-dialysis-modality-and-related-mortality-outcomes-in-korea-a-national-population-based-study
#5
Hyung Jong Kim, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Hyeong-Cheon Park, Shin-Wook Kang, Kyoung Hoon Kim, Dong-Ryeol Ryu, Hyunwook Kim
Background/Aims: Since comorbidities are major determinants of modality choice, and also interact with dialysis modality on mortality outcomes, we examined the pattern of modality choice according to comorbidities and then evaluated how such choices affected mortality in incident dialysis patients. Methods: We analyzed 32,280 incident dialysis patients in Korea. Patterns in initial dialysis choice were assessed by multivariate logistic regression analyses. Multivariate Poisson regression analyses were performed to evaluate the effects of interactions between comorbidities and dialysis modality on mortality and to quantify these interactions using the synergy factor...
June 26, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28651252/combined-diffusion-tensor-and-magnetic-resonance-spectroscopic-imaging-methodology-for-automated-regional-brain-analysis-application-in-a-normal-pediatric-population
#6
Nirmalya Ghosh, Barbara Holshouser, Udo Oyoyo, Stanley Barnes, Karen Tong, Stephen Ashwal
During human brain development, anatomic regions mature at different rates. Quantitative anatomy-specific analysis of longitudinal diffusion tensor imaging (DTI) and magnetic resonance spectroscopic imaging (MRSI) data may improve our ability to quantify and categorize these maturational changes. Computational tools designed to quickly fuse and analyze imaging information from multiple, technically different datasets would facilitate research on changes during normal brain maturation and for comparison to disease states...
June 27, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28651150/cognitive-remediation-improves-executive-functions-self-regulation-and-quality-of-life-in-residents-of-a-substance-use-disorder-therapeutic-community
#7
Ely M Marceau, Jamie Berry, Joanne Lunn, Peter J Kelly, Nadia Solowij
BACKGROUND: Executive dysfunction is common in substance use disorder (SUD) populations and hinders treatment. We previously found that 50% of residents in SUD therapeutic communities had been hospitalized for head injuries; this was a significant determinant of cognitive impairment. The current study aimed to establish whether cognitive remediation improves executive functions (EFs) and self-regulation in an ecologically valid sample of female residents attending SUD therapeutic community treatment, including those with past head injuries and psychiatric comorbidities...
June 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28651114/isolation-and-functional-interrogation-of-adult-human-prostate-epithelial-stem-cells-at-single-cell-resolution
#8
Wen-Yang Hu, Dan-Ping Hu, Lishi Xie, Ye Li, Shyama Majumdar, Larisa Nonn, Hong Hu, Toshi Shioda, Gail S Prins
Using primary cultures of normal human prostate epithelial cells, we developed a novel prostasphere-based, label-retention assay that permits identification and isolation of stem cells at a single cell level. Their bona fide stem cell nature was corroborated using in vitro and in vivo regenerative assays and documentation of symmetric/asymmetric division. Robust WNT10B and KRT13 levels without E-cadherin or KRT14 staining distinguished individual stem cells from daughter progenitors in spheroids. Following FACS to isolate label-retaining stem cells from label-free progenitors, RNA-seq identified unique gene signatures for the separate populations which may serve as useful biomarkers...
June 16, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28651106/computer-based-speech-therapy-for-childhood-speech-sound-disorders
#9
REVIEW
Lisa Furlong, Shane Erickson, Meg E Morris
BACKGROUND: With the current worldwide workforce shortage of Speech-Language Pathologists, new and innovative ways of delivering therapy to children with speech sound disorders are needed. Computer-based speech therapy may be an effective and viable means of addressing service access issues for children with speech sound disorders. AIM: To evaluate the efficacy of computer-based speech therapy programs for children with speech sound disorders. METHOD: Studies reporting the efficacy of computer-based speech therapy programs were identified via a systematic, computerised database search...
June 15, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28651097/population-and-performance-analyses-of-four-major-populations-with-illumina-s-fgx-forensic-genomics-system
#10
Jennifer D Churchill, Nicole M M Novroski, Jonathan L King, Lay Hong Seah, Bruce Budowle
The MiSeq FGx Forensic Genomics System (Illumina) enables amplification and massively parallel sequencing of 59 STRs, 94 identity informative SNPs, 54 ancestry informative SNPs, and 24 phenotypic informative SNPs. Allele frequency and population statistics data were generated for the 172 SNP loci included in this panel on four major population groups (Chinese, African Americans, US Caucasians, and Southwest Hispanics). Single-locus and combined random match probability values were generated for the identity informative SNPs...
June 17, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28651055/pharmacokinetic-characterization-of-18-f-ucb-h-pet-radiopharmaceutical-in-the-rat-brain
#11
Guillaume Becker, Corentin Warnier, Maria Elisa Serrano, Mohamed Ali Bahri, Joël Mercier, Christian Lemaire, Eric Salmon, André Luxen, Alain Plenevaux
The synaptic vesicle glycoprotein 2A (SV2A), a protein essential to the proper nervous system function, is found in presynaptic vesicles. Thus, SV2A targeting, using dedicated radiotracers combined with positron emission tomography (PET), allows the assessment of synaptic density in the living brain. The first-in-class fluorinated SV2A specific radioligand, [(18)F]UCB-H, is now available at high-activity through an efficient radiosynthesis compliant with the current good manufacturing practices (cGMP). We report here a non-invasive method to quantify [(18)F]UCB-H binding in rat brain with microPET...
June 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28651047/prioritization-of-contaminants-of-emerging-concern-in-wastewater-treatment-plant-discharges-using-chemical-gene-interactions-in-caged-fish
#12
Edward J Perkins, Tanwir Habib, Barbara L Escalon, Jenna E Cavallin, Linnea Thomas, Matthew Weberg, Megan N Hughes, Kathleen M Jensen, Michael D Kahl, Daniel L Villeneuve, Gerald T Ankley, Natalia Garcia-Reyero
We examined whether contaminants present in surface waters could be prioritized for further assessment by linking the presence of specific chemicals to gene expression changes in exposed fish. Fathead minnows were deployed in cages for 2, 4, or 8 days at three locations near two different wastewater treatment plant discharge sites in the Saint Louis Bay, Duluth, MN and one upstream reference site. The biological impact of 51 chemicals detected in the surface water of 133 targeted chemicals was determined using biochemical endpoints, exposure activity ratios for biological and estrogenic responses, known chemical:gene interactions from biological pathways and knowledge bases, and analysis of the co-variance of ovary gene expression with surface water chemistry...
June 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28650986/evolutionary-history-and-phylogeographic-relationships-of-shrews-from-sorex-araneus-group
#13
Paweł Mackiewicz, Magdalena Moska, Heliodor Wierzbicki, Przemysław Gagat, Dorota Mackiewicz
Shrews of the Sorex genus are an evolutionarily successful group that includes more than 77 species widely distributed in Eurasia and North America. The genus is one of the rare cases where karyotypic changes reflect well the evolutionary relationships among its species. The taxa showing the greatest variation in karyotype are usually classified into the Sorex araneus group. Its evolution was associated with chromosomal rearrangements, which could have promoted fast diversification of this group into many chromosomal races and species...
2017: PloS One
https://www.readbyqxmd.com/read/28650745/longer-duration-antimicrobial-therapy-does-not-prevent-treatment-failure-in-high-risk-patients-with-complicated-intra-abdominal-infections
#14
Taryn E Hassinger, Christopher A Guidry, Ori D Rotstein, Therese M Duane, Heather L Evans, Charles H Cook, Patrick J O'neill, John E Mazuski, Reza Askari, Lena M Napolitano, Nicholas Namias, Preston R Miller, E Patchen Dellinger, Raul Coimbra, Christine S Cocanour, Kaysie L Banton, Joseph Cuschieri, Kimberley Popovsky, Robert G Sawyer
BACKGROUND: Recent studies have suggested the length of treatment of intra-abdominal infections (IAIs) can be shortened without detrimental effects on patient outcomes. However, data from high-risk patient populations are lacking. We hypothesized that patients at high risk for treatment failure will benefit from a longer course of antimicrobial therapy. METHODS: Patients enrolled in the Study to Optimize Peritoneal Infection Therapy (STOP-IT) trial were evaluated retrospectively to identify risk factors associated with treatment failure, which was defined as the composite outcome of recurrent IAI, surgical site infection, or death...
June 26, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28650730/yield-of-staging-laparoscopy-for-incurable-factors-in-chinese-patients-with-advanced-gastric-cancer
#15
Jun Huang, Hongliang Luo, Chengliang Zhou, Jianjun Zhan, Xionghui Rao, Gang Zhao, Zhengming Zhu
BACKGROUND: Although the role of staging laparoscopy (SL) in detecting radiologically occult M1 disease has been widely recognized, it is seldom used in China and its clinical value based on Chinese population has been rarely reported. The aim of this study is to identify the yield of SL for Chinese patients with advanced gastric cancer (AGC) and determine the proportions of patients in whom treatment plan is altered. MATERIALS AND METHODS: The clinical data were retrospectively collected from 879 AGC patients who underwent SL without any definite signs of disseminated disease on imaging examination...
June 26, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28650383/incomplete-viral-suppression-and-mortality-in-hiv-patients-after-antiretroviral-therapy-initiation
#16
Jennifer S Lee, Stephen R Cole, David B Richardson, Dirk P Dittmer, William C Miller, Richard D Moore, Mari Kitahata, Christopher Mathews, Kenneth Mayer, Elvin Geng, Chad J Achenbach, Joseph J Eron
OBJECTIVE: To determine whether there is a threshold of detectable HIV RNA under 1,000 copies/mL after antiretroviral therapy initiation associated with 10-year all-cause mortality. DESIGN: This study included nearly 8,000 patients from a US-based multicenter clinical cohort who started antiretroviral therapy between 1 January 1998 and 31 December 2013. Viral load was assessed six months after initiation of therapy. Patients were followed from six months after therapy initiation (between 1 July 1998 and 30 June 2014) until death, and data were administratively censored after 10 years or on 31 December 2014...
June 23, 2017: AIDS
https://www.readbyqxmd.com/read/28650250/a-retrospective-longitudinal-claims-based-comparison-of-concomitant-diagnoses-between-individuals-with-and-without-down-syndrome
#17
Amanda M Kong, Dana Hurley, Kristin A Evans, Diana Brixner, Csilla Csoboth, Jeannie Visootsak
BACKGROUND: Individuals with Down syndrome (DS) experience various comorbidities in excess of the prevalence seen among the non-DS population. However, the extent of the excess burden of comorbidities specifically within commercially and publicly insured DS populations aged < 21 years is not currently known. OBJECTIVES: To (a) describe the most common diagnoses among individuals with DS who have either commercial or Medicaid insurance and (b) compare the prevalence of those diagnoses between DS cases and non-DS controls...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28650246/economic-outcomes-of-first-line-regimen-switching-among-stable-patients-with-hiv
#18
Lisa Rosenblatt, Ami R Buikema, Jerry Seare, Lindsay G S Bengtson, Jonathan Johnson, Feng Cao, Angelina Villasis-Keever
BACKGROUND: Although switching of antiretroviral therapy (ART) is a valid approach for addressing treatment failure in patients with human immunodeficiency virus (HIV), ART changes among those who are well maintained on their current regimens may lead to the development of new side effects or resistance. OBJECTIVE: To examine the effect of first-line regimen switching on subsequent health care utilization and cost among stable HIV patients. METHODS: This was a retrospective claims data study of adult patients with HIV who initiated ART between 2007 and 2013 and had been treated with their initial regimens for at least 6 continuous months...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28650108/a-matched-pair-analysis-of-multicenter-long-term-follow-up-after-split-liver-transplantation-with-extended-right-grafts
#19
M W Ross, M Cescon, R Angelico, E Andorno, G Rossi, A Pinna, L De Carlis, U Baccarani, U Cillo, M Colledan, V Mazzaferro, G Tisone, M Rossi, F Tuzzolino, D Pagano, S Gruttadauria, G Mazariegos, B Gridelli, M Spada
Split liver transplantation has been proposed as an alternative to whole liver transplantation to expand the donor pool, but studies comparing adult long-term outcomes between the two methods are conflicting and limited. This is the first Italian multicenter study that retrospectively analyzed 119 matched-pair recipients of whole and extended right grafts for long-term survival outcomes. In the overall population, whole liver recipients showed higher patient survival at one- (93% vs. 73%), five- (87% vs. 65%) and ten-year (83% vs...
June 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28649938/epidemiology-and-survival-of-cervical-cancer-in-the-french-west-indies-data-from-the-martinique-cancer-registry-2002-2011
#20
K Melan, E Janky, J Macni, S Ulric-Gervaise, M-J Dorival, J Veronique-Baudin, C Joachim
BACKGROUND: The Caribbean ranks seventh among world regions most affected by cervical cancer. Social health inequalities, such as differences in access to screening services, engender disparities in incidence and mortality between low- and middle-income countries and industrialized countries. The French National Cancer Plan 2014-2019 focuses on reducing inequalities in cervical cancer. OBJECTIVE: The aim of this study was to describe the geographical distribution and overall survival of cervical cancer, based on data from a population-based cancer registry in Martinique (French West-Indies)...
2017: Global Health Action
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