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https://www.readbyqxmd.com/read/28548883/simultaneous-detection-of-oral-pathogens-in-subgingival-plaque-and-prostatic-fluid-of-men-with-periodontal-and-prostatic-diseases
#1
John Estemalik, Catherine Demko, Nabil F Bissada, Nishant Joshi, Donald Bodner, Eswar Shankar, Sanjay Gupta
BACKGROUND: Chronic prostatitis (CP) and benign prostatic hyperplasia (BPH) are complex inflammatory conditions for which the etiological determinants are still poorly defined. Periodontitis is caused by subgingival colonizing bacteria in the oral cavity. The causal effect of periodontal disease on prostatic inflammation has not been established. The purpose of this study is to isolate oral pathogens from expressed prostatic secretions of patients with periodontal disease and chronic prostatitis or benign prostatic hyperplasia...
May 26, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28544711/greenlight-xps-for-treating-benign-prostatic-hyperplasia-%C3%A2-nice-2016-greenlight-xps-for-treating-benign-prostatic-hyperplasia
#2
(no author information available yet)
No abstract text is available yet for this article.
June 2017: BJU International
https://www.readbyqxmd.com/read/28540994/clinical-efficacy-and-safety-of-naftopidil-treatment-for-patients-with-benign-prostatic-hyperplasia-and-hypertension-a-prospective-open-label-study
#3
Mun Su Chung, Byung Il Yoon, Seung Hwan Lee
PURPOSE: To investigate the efficacy and safety of naftopidil for benign prostatic hyperplasia (BPH) patients, mainly focusing on changes in blood pressure (BP). MATERIALS AND METHODS: Of a total of 118 patients, 90 normotensive (NT) and 28 hypertensive (HT) patients were randomly assigned to be treated with naftopidil 50 mg or 75 mg for 12 weeks, once-daily. Safety and efficacy were assessed by analyzing changes from baseline in systolic/diastolic BP and total International Prostate Symptom Score (IPSS) at 4 and 12 weeks...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28540239/the-impact-and-management-of-sexual-dysfunction-secondary-to-pharmacological-therapy-of-benign-prostatic-hyperplasia
#4
REVIEW
Jason Gandhi, Steven J Weissbart, Noel L Smith, Steven A Kaplan, Gautam Dagur, Anna Zumbo, Gargi Joshi, Sardar Ali Khan
Benign prostatic hyperplasia (BPH) is one of the most common genitourinary complications in men over 50 years of age and typically presents with lower urinary tract symptoms (LUTS). Classes of medications include α1-adrenoceptor blockers, 5α-reductase inhibitors, and phosphodiesterase 5 inhibitors. Today, α1-adrenoceptor blockers and 5α-reductase inhibitors are often combined to give a synergistic effect. A review of the current literature identified several adverse sexual side effects, including erectile dysfunction (ED), decreased libido, orgasmic disorders, and ejaculatory disorders...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28540231/use-of-botulinum-toxin-for-voiding-dysfunction
#5
REVIEW
David Eldred-Evans, Prokar Dasgupta
The use of botulinum toxin A (BoNT-A) has expanded across a range of lower urinary tract conditions. This review provides an overview of the current indications for BoNT-A in the lower urinary tract and critically evaluates the published evidence within each area. The classic application of BoNT-A has been in the management of refractory neurogenic detrusor overactivity (NDO) and overactive bladder (OAB). There is a large volume of high-quality evidence, including numerous randomized placebo-controlled trials, which demonstrate the efficacy of BoNT-A over a long follow-up period...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28535984/prostate-arterial-embolization-is-a-viable-option-for-treating-symptoms-of-benign-prostatic-hyperplasia-con
#6
Steven A Kaplan
No abstract text is available yet for this article.
May 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28535983/prostate-arterial-embolization-is-a-viable-option-for-treating-symptoms-of-benign-prostatic-hyperplasia-pro
#7
Shamar Young, Jafar Golzarian
No abstract text is available yet for this article.
May 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28532766/morcellation-efficiency-in-holmium-laser-enucleation-of-the-prostate-oscillating-morcellator-outperforms-reciprocating-morcellator-with-no-apparent-learning-curve
#8
Sean McAdams, Rafael Nunez-Nateras, Christopher J Martin, Stephen Cha, Mitchell R Humphreys
OBJECTIVE: To compare the morcellation efficiency of the Wolf® Piranha™ oscillating morcellator to the Lumenis® VersaCut™ reciprocating morcellator. METHODS: After IRB approval, we conducted a retrospective analysis of patients undergoing HoLEP for symptomatic benign prostatic hyperplasia. The first 41 cases of HoLEP with morcellation performed with the oscillating morcellator were matched by weight of resected tissue to 41 control patients from our historic data set that underwent morcellation with the reciprocating system...
May 19, 2017: Urology
https://www.readbyqxmd.com/read/28532481/identification-of-endonuclease-domain-containing-1-as-a-novel-tumor-suppressor-in-prostate-cancer
#9
Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao, Wenhan Qiu, Ke Li, Dejuan Wang
BACKGROUND: Endonuclease domain containing 1 (ENDOD1) is implicated in tumorigenesis and aggressiveness of multiple tumors. In this study, we aimed to investigate the role of ENDOD1 in prostate cancer (PCa). METHODS: Immunohistochemistry were performed in 30 cases of benign prostatic hyperplasia (BPH) and 50 cases of PCa to identify its association with clinicopathological characteristics. Real-time PCR and western blot were used to detect ENDOD1 mRNA and protein expression in normal prostatic epithelial and PCa cell lines...
May 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28532455/a-retrospective-study-of-treatment-persistence-and-adherence-to-%C3%AE-blocker-plus-antimuscarinic-combination-therapies-in-men-with-luts-bph-in-the-netherlands
#10
Marcus J Drake, Sally Bowditch, Emilio Arbe, Zalmai Hakimi, Florent Guelfucci, Ikbel Amri, Jameel Nazir
BACKGROUND: To assess treatment persistence and adherence in men ≥45 years of age with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), using prescription records from the Netherlands IMS Lifelink™ LRx database. METHODS: In this retrospective, observational cohort study, we identified men who received combination therapy with an α-blocker plus an antimuscarinic (e.g. solifenacin or tolterodine) between 1 November 2013 and 31 October 2014...
May 22, 2017: BMC Urology
https://www.readbyqxmd.com/read/28532232/a-two-week-double-blind-placebo-controlled-trial-of-viola-odorata-echium-amoenum-and-physalis-alkekengi-mixture-in-symptomatic-benign-prostate-hyperplasia-bph-men
#11
Fatemeh Beiraghdar, Behzad Einollahi, Alireza Ghadyani, Yunes Panahi, Abbas Hadjiakhoondi, Mahdi Vazirian, Ali Salarytabar, Behrad Darvishi
CONTEXT: As an alternative approach, administration of phytotherapeutic agents in management of benign prostate hyperplasia (BPH), is rapidly growing each day. Different authors have indicated effectiveness of Viola odorata L. (Violaceae), Echium amoenum Fisch. & C.A.Mey. (Boraginaceae) and Physalis alkekengi L. (Solanaceae) in treatment of BPH. However, none have reported the beneficial outcomes of the mixture yet. OBJECTIVE: This study evaluates the therapeutical effects of V...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28530080/-cataract-surgery-complications-in-males-treated-with-alpha-1-antagonists-for-benign-prostatic-hyperplasia
#12
REVIEW
Tamar Pedut Kloizman, Raneen Shehadeh Mashour
Intraoperative floppy iris syndrome (IFIS) was first described by Chang and Campbell in 2005. The characteristics of this syndrome include: 1. Floppy iris that billows in reaction to intraocular fluid currents during standard phacoemulsification procedure; 2. Flaccid iris stroma that tends to prolapse through well-constructed surgical incisions; 3. Insufficient pupillary mydriasis despite proper pharmacologic preparation and progressive pupillary constriction during the operation. Surgical procedures with IFIS have since been noted to have an exceptionally high rate of complications, some of which can be vision threatening...
September 2016: Harefuah
https://www.readbyqxmd.com/read/28529746/morphological-changes-in-peri-prostatic-sympathetic-ganglion-cells-in-aging-males
#13
Lea Rath-Wolfson, Asaf Shvero, Golan Bubis, Galina Buzaverov, Aliza Zeidman, Edward Ram, Rumelia Koren
A significant part of morbidity in elderly male patients involves the pelvic organs and their autonomic neural regulation. The aim of the current study was to report the histopathological changes in the peri-prostatic ganglia in elderly males. The sympathetic ganglia from 36 prostatectomy specimens, 26 due to carcinoma of the prostate and 10 prostates from total cystectomies for transitional cell carcinoma, were examined. The age range was 54-88 years. A total of 5,075 ganglion cells were counted in all the specimens...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28527622/genome-wide-copy-number-analysis-reveals-candidate-gene-loci-that-confer-susceptibility-to-high-grade-prostate-cancer
#14
Prevathe Poniah, Shamsul Mohd Zain, Azad Hassan Abdul Razack, Shanggar Kuppusamy, Shankar Karuppayah, Hooi Sian Eng, Zahurin Mohamed
BACKGROUND: Two key issues in prostate cancer (PCa) that demand attention currently are the need for a more precise and minimally invasive screening test owing to the inaccuracy of prostate-specific antigen and differential diagnosis to distinguish advanced vs. indolent cancers. This continues to pose a tremendous challenge in diagnosis and prognosis of PCa and could potentially lead to overdiagnosis and overtreatment complications. Copy number variations (CNVs) in the human genome have been linked to various carcinomas including PCa...
May 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28514735/kif7-attenuates-prostate-tumor-growth-through-lkb1-mediated-akt-inhibition
#15
Kai Yau Wong, Jing Liu, Kwok Wah Chan
This study investigated kinesin family member 7 (KIF7) expression and function in prostate cancer (PCa). Our results showed that KIF7 was significantly downregulated in PCa, compared with normal, benign prostatic hyperplasia and prostate intraepithelial neoplasia tissues, partially through promoter hypermethylation. We further investigated the effects of KIF7 coiled coil (CC) domain and motor domain (MD) on PCa development in vitro and in vivo. Our results showed that KIF7-CC but not KIF7-MD significantly attenuated proliferation and colony formation, impeded migration and invasion, induced apoptosis and sensitized PCa cells to paclitaxel...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28509060/-management-of-benign-prostatic-hyperplasia-bph
#16
Jan-Friedrich Jokisch, Annika Herlemann, Philipp Weinhold, Giuseppe Magistro, Christian G Stief, Christian Gratzke
No abstract text is available yet for this article.
May 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28508455/a-multicenter-real-life-study-of-the-efficacy-of-an-alpha-blocker-with-or-without-anticholinergic-agent-imidafenacin-treatment-in-patients-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-and-storage-symptoms
#17
Seok Cho, Soon-Sun Kwon, Kwang Woo Lee, Tag Keun Yoo, Dong Gil Shin, Soo Woong Kim, Jae Hyun Bae, Hoon Choi, Young Ho Kim
AIMS: To evaluate the efficacy and safety of combination therapy comprising a short-acting anticholinergic, imidafenacin and an alpha-blocker compared with monotherapy with an alpha-blocker only in men with lower urinary tract symptoms (LUTS) and storage symptoms. METHODS: The 12-week, prospective, double-blind, randomised trial enrolled men with LUTS and storage symptom. The inclusion criteria were a total International Prostate Symptom Score (IPSS) ≥12, an IPSS question 4 score ≥2, ≥8 micturitions in 24 hours, and a prostate volume >20 mL...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28508252/anatomical-variants-in-prostate-artery-embolization-a-pictorial-essay
#18
Francisco Cesar Carnevale, Guilherme Rebello Soares, Andre Moreira de Assis, Airton Mota Moreira, Sardis Honoria Harward, Giovanni Guido Cerri
Prostate artery embolization (PAE) has emerged as a new treatment option for patients with symptomatic benign prostatic hyperplasia. The main challenges related to this procedure are navigating arteries with atherosclerosis and anatomical variations, and the potential risk of non-target embolization to pelvic structures due to the presence of collateral shunts and reflux of microparticles. Knowledge of classical vascular anatomy and the most common variations is essential for safe embolization, good clinical practice, and optimal outcomes...
May 15, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28508246/the-significance-of-histological-analysis-following-laser-transurethral-resection-of-the-prostate
#19
Shady Nafie, John Dormer, Masood A Khan
PURPOSE: Monopolar transurethral resection of the prostate is the gold standard for the treatment of benign prostatic hyperplasia. However, due to the associated risks of bleeding and TUR syndrome, laser prostate surgery is gaining popularity. We perform thulium-laser vaporesection of the prostate (TmLRP), where histological samples are generated in every case. We determined postoperative incidence and significance of prostate cancer detection, by retrospective histological examination of our cases...
May 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28507619/expression-of-erg-protein-and-tmrpss2-erg-fusion-in-prostatic-carcinoma-in-egyptian-patients
#20
Ahmed Abdel-Hady, Ali El-Hindawi, Olfat Hammam, Heba Khalil, Sara Diab, Soulafa Abd El-Aziz, Mohamed Badawy, Ahmed Ismail, Noha Helmy, Nora Kamel, Shady Anis, Amr El Kholy, Khalid Al Osili, Afaf Abdel-Hady, Hani Nour, Maha Akl
AIM: Prostate cancer (PCa) is the second most common cancers in men worldwide. Its incidence can be influenced by several risk factors including genetic susceptibility. Therefore the search for the expression of a certain gene (ERG) and its rearrangement could give us clues for proper identification of PCa. And the study of ERG expression and its comparison to FISH in Egyptian patients can show whether ERG immunophenotype could be used instead of FISH, as it is cheaper. MATERIALS AND METHODS: This study was performed on 85 cases of PCa, showing 30 cases with HGPIN and 30 cases of prostatic hyperplasia...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
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