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https://www.readbyqxmd.com/read/27875721/percutaneous-mitral-valve-repair-the-last-chance-for-symptoms-improvement-in-advanced-refractory-chronic-heart-failure
#1
Alessandra Berardini, Elena Biagini, Francesco Saia, Davide Stolfo, Mario Previtali, Francesco Grigioni, Bruno Pinamonti, Gabriele Crimi, Alessandro Salvi, Maurizio Ferrario, Antonio De Luca, Fabrizio Gazzoli, Maria Letizia Bacchi Reggiani, Claudia Raineri, Gianfranco Sinagra, Claudio Rapezzi
BACKGROUND: The role of percutaneous mitral valve repair (PMVR) in patients with end-stage heart failure (HF) and functional mitral regurgitation (FMR) is unclear. METHODS: Seventy-five consecutive patients with FMR grade≥3+ and severe HF symptoms despite optimal medical therapy and resynchronization therapy underwent PMVR with the MitraClip system (Abbott, Abbott Park, IL, USA) at 3 centers. Clinical evaluation, echocardiography and pro-BNP measurement were performed at baseline and at 6-month...
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27828830/right-ventricular-arrhythmogenic-cardiomyopathy-genetic-and-mr-for-modern-clinical-diagnosis
#2
Maddalena Graziosi, Claudio Rapezzi
No abstract text is available yet for this article.
November 8, 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/27813534/splanchnic-vein-thrombosis-in-myeloproliferative-neoplasms-risk-factors-for-recurrences-in-a-cohort-of-181-patients
#3
V De Stefano, A M Vannucchi, M Ruggeri, F Cervantes, A Alvarez-Larrán, A Iurlo, M L Randi, L Pieri, E Rossi, P Guglielmelli, S Betti, E Elli, M C Finazzi, G Finazzi, E Zetterberg, N Vianelli, G Gaidano, I Nichele, D Cattaneo, M Palova, M H Ellis, E Cacciola, A Tieghi, J C Hernandez-Boluda, E Pungolino, G Specchia, D Rapezzi, A Forcina, C Musolino, A Carobbio, M Griesshammer, T Barbui
We retrospectively studied 181 patients with polycythaemia vera (n=67), essential thrombocythaemia (n=67) or primary myelofibrosis (n=47), who presented a first episode of splanchnic vein thrombosis (SVT). Budd-Chiari syndrome (BCS) and portal vein thrombosis were diagnosed in 31 (17.1%) and 109 (60.3%) patients, respectively; isolated thrombosis of the mesenteric or splenic veins was detected in 18 and 23 cases, respectively. After this index event, the patients were followed for 735 patient years (pt-years) and experienced 31 recurrences corresponding to an incidence rate of 4...
November 4, 2016: Blood Cancer Journal
https://www.readbyqxmd.com/read/27798053/relationship-between-aetiology-and-left-ventricular-systolic-dysfunction-in-hypertrophic-cardiomyopathy
#4
Stefania Rosmini, Elena Biagini, Costantinos O'Mahony, Heerajnarain Bulluck, Niccolo' Ruozi, Luis R Lopes, Oliver Guttmann, Patricia Reant, Cristina C Quarta, Antonis Pantazis, Maria Tome-Esteban, William J Mckenna, Claudio Rapezzi, Perry M Elliott
BACKGROUND: Severe left ventricular (LV) systolic dysfunction is an uncommon complication of hypertrophic cardiomyopathy (HCM) that is associated with poor prognosis. Small observational series suggest that patients with rare causes of HCM are more likely to develop systolic impairment than those with idiopathic disease or mutations in cardiac sarcomeric protein genes. The aim of this study was to test this hypothesis by comparing the prevalence of systolic dysfunction and its impact on prognosis in patients with different causes of HCM...
October 24, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27794017/predictors-of-atrial-fibrillation-in-hypertrophic-cardiomyopathy
#5
Oliver P Guttmann, Menelaos Pavlou, Constantinos O'Mahony, Lorenzo Monserrat, Aristides Anastasakis, Claudio Rapezzi, Elena Biagini, Juan Ramon Gimeno, Giuseppe Limongelli, Pablo Garcia-Pavia, William J McKenna, Rumana Z Omar, Perry M Elliott
OBJECTIVES: Atrial fibrillation (AF) is associated with increased morbidity and mortality in patients with hypertrophic cardiomyopathy (HCM). The primary aim of this study (HCM Risk-AF) was to determine the predictors of AF in a large multicentre cohort of patients with HCM. Exploratory analyses were performed to investigate the association between AF and survival and the efficacy of antiarrhythmic therapy in maintaining sinus rhythm (SR). METHODS: A retrospective, longitudinal cohort of patients recruited between 1986 and 2008 in seven centres was used to develop multivariable Cox regression models fitted with preselected predictors...
October 28, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27618852/histological-and-histometric-characterization-of-myocardial-fibrosis-in-end-stage-hypertrophic-cardiomyopathy-a-clinical-pathological-study-of-30-explanted-hearts
#6
Giuseppe Galati, Ornella Leone, Ferdinando Pasquale, Iacopo Olivotto, Elena Biagini, Francesco Grigioni, Emanuele Pilato, Massimiliano Lorenzini, Barbara Corti, Alberto Foà, Valentina Agostini, Franco Cecchi, Claudio Rapezzi
BACKGROUND: Although noninvasively detected myocardial fibrosis (MF) has clinical implications in hypertrophic cardiomyopathy, the extent, type, and distribution of ventricular MF have never been extensively pathologically characterized. We assessed the overall amount, apex-to-base, circumferential, epicardial-endocardial distribution, pattern, and type of MF in 30 transplanted hearts of end-stage, hypertrophic cardiomyopathy. METHODS AND RESULTS: Visual and morphometric histological analyses at basal, midventricular, and apical levels were performed...
September 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27600940/targeted-next-generation-sequencing-helps-to-decipher-the-genetic-and-phenotypic-heterogeneity-of-hypertrophic-cardiomyopathy
#7
Massimiliano Cecconi, Maria I Parodi, Francesco Formisano, Paolo Spirito, Camillo Autore, Maria B Musumeci, Stefano Favale, Cinzia Forleo, Claudio Rapezzi, Elena Biagini, Sabrina Davì, Elisabetta Canepa, Loredana Pennese, Mauro Castagnetta, Dario Degiorgio, Domenico A Coviello
Hypertrophic cardiomyopathy (HCM) is mainly associated with myosin, heavy chain 7 (MYH7) and myosin binding protein C, cardiac (MYBPC3) mutations. In order to better explain the clinical and genetic heterogeneity in HCM patients, in this study, we implemented a target-next generation sequencing (NGS) assay. An Ion AmpliSeq™ Custom Panel for the enrichment of 19 genes, of which 9 of these did not encode thick/intermediate and thin myofilament (TTm) proteins and, among them, 3 responsible of HCM phenocopy, was created...
October 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27585509/genetic-screening-of-anderson-fabry-disease-in-probands-referred-from-multispecialty-clinics
#8
Valentina Favalli, Eliana Disabella, Mariadelfina Molinaro, Marilena Tagliani, Anna Scarabotto, Alessandra Serio, Maurizia Grasso, Nupoor Narula, Carmela Giorgianni, Clelia Caspani, Monica Concardi, Manuela Agozzino, Calogero Giordano, Alexandra Smirnova, Takahide Kodama, Lorenzo Giuliani, Elena Antoniazzi, Riccardo G Borroni, Camilla Vassallo, Filippo Mangione, Laura Scelsi, Stefano Ghio, Carlo Pellegrini, Marialuisa Zedde, Laura Fancellu, GianPietro Sechi, Antonello Ganau, Stefania Piga, Annarita Colucci, Daniela Concolino, Maria Teresa Di Mascio, Danilo Toni, Marina Diomedi, Claudio Rapezzi, Elena Biagini, Massimiliano Marini, Maurizia Rasura, Maurizio Melis, Antonia Nucera, Donata Guidetti, Michelangelo Mancuso, Umberto Scoditti, Pamela Cassini, Jagat Narula, Luigi Tavazzi, Eloisa Arbustini
BACKGROUND: Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disease, caused by defects of the alpha-galactosidase A (GLA) gene. AFD can affect the heart, brain, kidney, eye, skin, peripheral nerves, and gastrointestinal tract. Cardiology (hypertrophic cardiomyopathy), neurology (cryptogenic stroke), and nephrology (end-stage renal failure) screening studies suggest the prevalence of GLA variants is 0.62%, with diagnosis confirmation in 0.12%. OBJECTIVES: This study sought to expand screening from these settings to include ophthalmology, dermatology, gastroenterology, internal medicine, pediatrics, and medical genetics to increase diagnostic yield and comprehensively evaluate organ involvement in AFD patients...
September 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27582761/balloon-aortic-valvuloplasty-as-a-bridge-to-decision-in-high-risk-patients-with-aortic-stenosis-a-new-paradigm-for-the-heart-team-decision-making
#9
Francesco Saia, Carolina Moretti, Gianni Dall'Ara, Cristina Ciuca, Nevio Taglieri, Alessandra Berardini, Pamela Gallo, Marina Cannizzo, Matteo Chiarabelli, Niccolò Ramponi, Linda Taffani, Maria Letizia Bacchi-Reggiani, Cinzia Marrozzini, Claudio Rapezzi, Antonio Marzocchi
BACKGROUND: Whilst the majority of the patients with severe aortic stenosis can be directly addressed to surgical aortic valve replacement (AVR) or transcatheter aortic valve implantation (TAVI), in some instances additional information may be needed to complete the diagnostic workout. We evaluated the role of balloon aortic valvuloplasty (BAV) as a bridge-to-decision (BTD) in selected high-risk patients. METHODS: Between 2007 and 2012, the heart team in our Institution required BTD BAV in 202 patients...
September 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27532449/adherence-to-agents-acting-on-the-renin-angiotensin-system-in-secondary-prevention-of-non-fatal-myocardial-infarction-a-self-controlled-case-series-study
#10
Paolo Ortolani, Stefano Di Bartolomeo, Massimiliano Marino, Fabio Vagnarelli, Paolo Guastaroba, Claudio Rapezzi, Rossana De Palma
AIMS: In accordance with current guidelines, patients discharged after acute myocardial infarction (AMI) are usually prescribed agents acting on the renin-angiotensin system (ACE-I/ARB). However, adherence to prescribing medications is a recognized problem and most studies demonstrating the value of adherence were limited by their non-randomized design and by 'healthy-adherer' bias. Herein we sought to evaluate the relationship between adherence to ACE-I/ARB and risk of subsequent AMIs, by using the self-controlled case-series design which virtually eliminates interpersonal confounding, being based on intrapersonal comparisons...
October 2015: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27391212/risk-of-stroke-in-patients-with-stable-coronary-artery-disease-undergoing-percutaneous-coronary-intervention-versus-optimal-medical-therapy-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Nevio Taglieri, Maria Letizia Bacchi Reggiani, Gabriele Ghetti, Francesco Saia, Gianni Dall'Ara, Pamela Gallo, Carolina Moretti, Tullio Palmerini, Cinzia Marrozzini, Antonio Marzocchi, Claudio Rapezzi
BACKGROUND: Stroke is a rare but serious adverse event associated with percutaneous coronary intervention (PCI). However, the relative risk of stroke between stable patients undergoing a direct PCI strategy and those undergoing an initial optimal medical therapy (OMT) strategy has not been established yet. This study sought to investigate if, in patients with stable coronary artery disease (SCAD), an initial strategy PCI is associated with a higher risk of stroke than a strategy based on OMT alone...
2016: PloS One
https://www.readbyqxmd.com/read/27386769/genotype-and-phenotype-of-transthyretin-cardiac-amyloidosis-thaos-transthyretin-amyloid-outcome-survey
#12
Mathew S Maurer, Mazen Hanna, Martha Grogan, Angela Dispenzieri, Ronald Witteles, Brian Drachman, Daniel P Judge, Daniel J Lenihan, Stephen S Gottlieb, Sanjiv J Shah, D Eric Steidley, Hector Ventura, Srinivas Murali, Marc A Silver, Daniel Jacoby, Savitri Fedson, Scott L Hummel, Arnt V Kristen, Thibaud Damy, Violaine Planté-Bordeneuve, Teresa Coelho, Rajiv Mundayat, Ole B Suhr, Márcia Waddington Cruz, Claudio Rapezzi
BACKGROUND: Transthyretin amyloidosis (ATTR) is a heterogeneous disorder with multiorgan involvement and a genetic or nongenetic basis. OBJECTIVES: The goal of this study was to describe ATTR in the United States by using data from the THAOS (Transthyretin Amyloidosis Outcomes Survey) registry. METHODS: Demographic, clinical, and genetic features of patients enrolled in the THAOS registry in the United States (n = 390) were compared with data from patients from other regions of the world (ROW) (n = 2,140)...
July 12, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27289293/usefulness-of-electrocardiographic-patterns-at-presentation-to-predict-long-term-risk-of-cardiac-death-in-patients-with-hypertrophic-cardiomyopathy
#13
Elena Biagini, Chiara Pazzi, Iacopo Olivotto, Beatrice Musumeci, Giuseppe Limongelli, Giuseppe Boriani, Giuseppe Pacileo, Vittoria Mastromarino, Maria Letizia Bacchi Reggiani, Massimiliano Lorenzini, Francesco Lai, Alessandra Berardini, Francesca Mingardi, Stefania Rosmini, Elvira Resciniti, Claudia Borghi, Camillo Autore, Franco Cecchi, Claudio Rapezzi
The objective of this study was to investigate the prognostic significance of 12-lead electrocardiogram (ECG) patterns in a large multicenter cohort of patients with hypertrophic cardiomyopathy; 1,004 consecutive patients with hypertrophic cardiomyopathy and a recorded standard ECG (64% men, mean age 50 ± 16 years) were evaluated at 4 Italian centers. The study end points were sudden cardiac death (SCD) or surrogates, including appropriate implanted cardiac defibrillator discharge and resuscitated cardiac arrest and major cardiovascular events (including SCD or surrogates and death due to heart failure, cardioembolic stroke, or heart transplantation)...
August 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27260015/personal-history-and-quality-of-life-in-chronic-myeloid-leukemia-patients-a-cross-sectional-study-using-narrative-medicine-and-quantitative-analysis
#14
Massimo Breccia, Guendalina Graffigna, Sara Galimberti, Alessandra Iurlo, Ester Pungolino, Michele Pizzuti, Alessandro Maggi, Franca Falzetti, Silvana Franca Capalbo, Tamara Intermesoli, Margherita Maffioli, Chiara Elena, Alessandro Melosi, Federico Simonetti, Enrico Capochiani, Roberta Della Seta, Matteo Pacilli, Mario Luppi, Nicola Di Renzo, Lucia Mastrullo, Elena Trabacchi, Daniele Vallisa, Davide Rapezzi, Ester Maria Orlandi, Carlo Gambacorti-Passerini, Fabio Efficace, Giuliana Alimena
BACKGROUND: Tyrosine kinase inhibitors (TKIs) drastically changed the outcome of patients diagnosed with chronic myeloid leukemia (CML). Several reports indicated the advantage of continue long-term adherence associated with positive outcome. Therefore, it is important to better understand from the patient's standpoint the experience of living with the disease and the related treatment. OBJECTIVES: In this study, quantitative analysis and narrative medicine were combined to get insights on this issue in a population of 257 patients with CML in chronic phase treated with TKIs (43 % men, with a median age of 58 years, 27 % aged 31-50 years), followed for a median time of 5 years...
November 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27241837/effect-of-cardiac-resynchronization-therapy-on-left-atrial-size-and-function-as-expressed-by-speckle-tracking-2-dimensional-strain
#15
Cinzia Valzania, Fredrik Gadler, Giuseppe Boriani, Claudio Rapezzi, Maria J Eriksson
Changes in left atrial (LA) strain in patients treated with cardiac resynchronization therapy (CRT) remain not entirely explored. We prospectively evaluated long-term changes in LA size and function and their relation with left ventricular (LV) reverse remodeling and noninvasive hemodynamic variables in patients treated with CRT by 2-dimensional speckle tracking echocardiography. Thirty patients (62 ± 11 years, 63% men) underwent 2-dimensional speckle tracking echocardiography before implant and after 12 months...
July 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27217341/inverted-u-shaped-relation-between-the-risk-of-sudden-cardiac-death-and-maximal-left-ventricular-wall-thickness-in-hypertrophic-cardiomyopathy
#16
Constantinos O'Mahony, Fatima Jichi, Lorenzo Monserrat, Martin Ortiz-Genga, Aristides Anastasakis, Claudio Rapezzi, Elena Biagini, Juan Ramon Gimeno, Giuseppe Limongelli, William J McKenna, Rumana Z Omar, Perry M Elliott
BACKGROUND: Hypertrophic cardiomyopathy is associated with sudden cardiac death (SCD). Some studies have shown an association between risk of sudden death and left ventricular maximal wall thickness (MWT), but there are few data in patients with extreme hypertrophy. The aim of this study was to determine the relation between MWT and the risk of SCD. METHODS AND RESULTS: This is a multicenter, retrospective, longitudinal cohort study of 3673 adult (≥16 years) patients, previously used to develop and validate a risk prediction model for SCD (HCM Risk-SCD [hypertrophic cardiomyopathy risk-SCD])...
June 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27143678/nonbiopsy-diagnosis-of-cardiac-transthyretin-amyloidosis
#17
Julian D Gillmore, Mathew S Maurer, Rodney H Falk, Giampaolo Merlini, Thibaud Damy, Angela Dispenzieri, Ashutosh D Wechalekar, John L Berk, Candida C Quarta, Martha Grogan, Helen J Lachmann, Sabahat Bokhari, Adam Castano, Sharmila Dorbala, Geoff B Johnson, Andor W J M Glaudemans, Tamer Rezk, Marianna Fontana, Giovanni Palladini, Paolo Milani, Pierluigi L Guidalotti, Katarina Flatman, Thirusha Lane, Frederick W Vonberg, Carol J Whelan, James C Moon, Frederick L Ruberg, Edward J Miller, David F Hutt, Bouke P Hazenberg, Claudio Rapezzi, Philip N Hawkins
BACKGROUND: Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal cardiomyopathy for which several promising therapies are in development. The diagnosis is frequently delayed or missed because of the limited specificity of echocardiography and the traditional requirement for histological confirmation. It has long been recognized that technetium-labeled bone scintigraphy tracers can localize to myocardial amyloid deposits, and use of this imaging modality for the diagnosis of cardiac ATTR amyloidosis has lately been revisited...
June 14, 2016: Circulation
https://www.readbyqxmd.com/read/27113812/high-rate-of-recurrent-venous-thromboembolism-in-patients-with-myeloproliferative-neoplasms-and-effect-of-prophylaxis-with-vitamin-k-antagonists
#18
V De Stefano, M Ruggeri, F Cervantes, A Alvarez-Larrán, A Iurlo, M L Randi, E Elli, M C Finazzi, G Finazzi, E Zetterberg, N Vianelli, G Gaidano, E Rossi, S Betti, I Nichele, D Cattaneo, M Palova, M H Ellis, R Cacciola, A Tieghi, J C Hernandez-Boluda, E Pungolino, G Specchia, D Rapezzi, A Forcina, C Musolino, A Carobbio, M Griesshammer, E Sant'Antonio, A M Vannucchi, T Barbui
The optimal duration of treatment with vitamin K antagonists (VKA) after venous thromboembolism (VTE) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) is uncertain. To tackle this issue, we retrospectively studied 206 patients with MPN-related VTE (deep venous thrombosis of the legs and/or pulmonary embolism). After this index event, we recorded over 695 pt-years 45 recurrences, venous in 36 cases, with an incidence rate (IR) of 6.5 per 100 pt-years (95% confidence interval (CI): 4...
October 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27044657/electrocardiographic-eligibility-for-subcutaneous-implantable-cardioverter-defibrillator-evaluation-during-bicycle-exercise
#19
Matteo Ziacchi, Alessandro Corzani, Igor Diemberger, Cristian Martignani, Alessandro Marziali, Andrea Mazzotti, Giulia Massaro, Claudio Rapezzi, Mauro Biffi, Giuseppe Boriani
BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is used in patients at risk of sudden death. Our aim was to assess clinical predictors of electrocardiographic ineligibility for S-ICD, and the impact of exercise on S-ICD eligibility in an unselected series of patients requiring ICD therapy. METHODS: 102 patients at risk of sudden death were evaluated at rest and during exercise. Electrocardiograph screening using limb lead electrodes (to simulate the S-ICD sensing vectors) was performed at rest and during bicycle ergometer exercise...
May 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/26976144/does-the-etiology-of-cardiac-amyloidosis-determine-the-myocardial-uptake-of-18f-naf-pet-ct
#20
Christian Gagliardi, Elena Tabacchi, Rachele Bonfiglioli, Stefania Diodato, Cristina Nanni, Pierluigi Guidalotti, Massimiliano Lorenzini, Filippo Lodi, Agnese Milandri, Claudio Rapezzi, Stefano Fanti
Cardiac amyloidosis (CA) leads to variable degrees of myocardial infiltration with a final echocardiographic phenotype of "hypertrophy." Although many non-invasive imaging techniques (MRI, CT, scintigraphy, PET) are useful, the definitive diagnosis is still based on myocardial histology. We explored the possible role of [18F]-NaF PET/CT in the diagnosis of this disease in two cases with wild-type (ATTRwt) or mutant (ATTRm) Ile68Leu transthyretin (TTR)-related CA.
March 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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