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Avinainder Singh, Hallie I Geller, Kevin M Alexander, Robert F Padera, Richard N Mitchell, Sharmila Dorbala, Jorge J Castillo, Rodney H Falk
No abstract text is available yet for this article.
April 19, 2018: Haematologica
Michaela Falk, Aksel Bernhoft, Tore Framstad, Brit Salbu, Helene Wisløff, Trond M Kortner, Anja B Kristoffersen, Marianne Oropeza-Moe
The study was conducted to compare effects of different dietary Se sources (sodium selenite [NaSe], Se-enriched yeast [Se yeast] or L-selenomethionine [SeMet]) and one Se-deficient control diet on the expression of selected genes, hematological and clinical biochemical parameters, and muscle morphology in two parallel trials with finisher pigs. Se concentrations in blood plasma and tissues were also monitored. From the pigs in one of the parallel groups, muscle samples obtained from Musculus longissimus dorsi (LD) before and during the trial were examined...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
Seif Magdy Reda, Joachim Krois, Sophie Franziska Reda, William Murray Thomson, Falk Schwendicke
OBJECTIVES: Regular and/or preventive dental services utilization is an indicator of healthcare access and associated with improved health outcomes. We assessed the proportion of individuals regularly/preventively utilizing dental services, and how this was affected by demographic, health-related and social factors. SOURCES: Three electronic databases (Medline, Embase, Central) were searched (2005-2017). STUDY SELECTION: We included observational studies investigating the association between preventive/regular dental service utilization and age, oral and general health, edentulism, family structure and health literacy...
April 16, 2018: Journal of Dentistry
Edwin H G Oei, Marius C Wick, Anja Müller-Lutz, Christoph Schleich, Falk R Miese
Cartilage degeneration is one of the most common chronic age-related joint disorders leading to pain and reduced joint motion. The increasing prevalence of osteoarthritis requires accurate cartilage imaging, both clinically and in research. Detailed cartilage imaging is also necessary for traumatic cartilage lesions and for pre- and postoperative assessment of cartilage repair procedures. Although still widely used, conventional radiography bears significant limitations because it assesses cartilage indirectly by joint space width...
April 2018: Seminars in Musculoskeletal Radiology
Herbert Tempfer, Alexandra Kaser-Eichberger, Christine Lehner, Renate Gehwolf, Stefanie Korntner, Nadja Kunkel, Andrea Wagner, Moritz Gruetz, Ludwig M Heindl, Falk Schroedl, Andreas Traweger
BACKGROUND/AIMS: Effective wound-healing generally requires efficient re-vascularization after injury, ensuring sufficient supply with oxygen, nutrients, and various cell populations. While this applies to most tissues, tendons are mostly avascular in nature and harbor relatively few cells, probably contributing to their poor regenerative capacity. Considering the minimal vascularization of healthy tendons, we hypothesize that controlling angiogenesis in early tendon healing is beneficial for repair tissue quality and function...
April 16, 2018: Cellular Physiology and Biochemistry
Camilla Wistrand, Karin Falk-Brynhildsen, Ulrica Nilsson
BACKGROUND: Surgical site infection (SSI), the third most common type of nosocomial infection in Sweden, is a patient injury that should be prevented. Methods of reducing SSIs include, for instance, disinfecting the skin, maintaining body temperature, and ensuring an aseptic environment. Guidelines for most of these interventions exist, but there is a lack of studies describing to what extent the preventive interventions have been implemented in clinical practice. We describe the daily clinical interventions Swedish operating room (OR) nurses performed to prevent SSIs following national guidelines...
April 19, 2018: Surgical Infections
Christian J Bachmann, Bettina Gerste, Falk Hoffmann
For Germany, no data on trends in autism spectrum disorder diagnoses are available. The primary aim of this study was to establish the time trends in the administrative prevalence of autism spectrum disorder diagnoses. The second aim was to assess the stability of autism spectrum disorder diagnoses over time. We analysed administrative outpatient data (2006-2012) from a nationwide health insurance fund and calculated the prevalence of autism spectrum disorder diagnoses for each year, stratified by age and sex...
April 2018: Autism: the International Journal of Research and Practice
Nathan Falk, Ariel Cole, T Jason Meredith
Dementia is a significant and costly health condition that affects 5 million adults and is the fifth leading cause of death among Americans older than 65 years. The prevalence of dementia will likely increase in the future because the number of Americans older than 65 years is expected to double by 2060. Risk factors for dementia include age; family history of dementia; personal history of cardiovascular disease, cerebrovascular disease, diabetes mellitus, or midlife obesity; use of anticholinergic medications; apolipoprotein E4 genotype; and lower education level...
March 15, 2018: American Family Physician
Michelle Clermont, Gary W Falk
Barrett's esophagus is a condition in which metaplastic columnar epithelium replaces stratified squamous epithelium in the distal esophagus. This condition occurs due to chronic gastroesophageal reflux disease and is a risk factor for the development of esophageal adenocarcinoma. Multiple clinical guidelines have been published around the world in recent years to assist gastroenterologists in the management of these patients and have evolved as new data have become available. While some information such as surveillance technique has not drastically changed, there has been an evolution over the years in diagnostic criteria, screening and endoscopic therapy with a variety of subtle differences among the different guidelines...
April 18, 2018: Digestive Diseases and Sciences
Ji Soo Lee, Jill L Sorcher, Allison D Rosen, Ruslan Damadzic, Hui Sun, Melanie Schwandt, Markus Heilig, John Kelly, Kelsey L Mauro, Audrey Luo, Daniel Rosoff, Christine Muench, Jeesun Jung, Zachary A Kaminsky, Falk W Lohoff
BACKGROUND: The gene encoding Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD. METHODS: We conducted a case-control association study of genetic variants in PIP5K1C...
April 18, 2018: Alcoholism, Clinical and Experimental Research
Thomas Krieg, Joana Madjarov, Luis F M Rosa, Franziska Enzmann, Falk Harnisch, Dirk Holtmann, Korneel Rabaey
From the first electromicrobial experiment to a sophisticated microbial electrochemical process - it all takes place in a reactor. Whereas the reactor design and materials used strongly influence the obtained results, there are no common platforms for MES reactors. This is a critical convention gap, as cross-comparison and benchmarking among MES as well as MES vs. conventional biotechnological processes is needed. Only knowledge driven engineering of MES reactors will pave the way to application and commercialization...
April 13, 2018: Advances in Biochemical Engineering/biotechnology
Guillaume Fertin, Falk Hüffner, Christian Komusiewicz, Manuel Sorge
In this paper, we introduce and analyze two graph-based models for assigning orthologs in the presence of whole-genome duplications, using similarity information between pairs of genes. The common feature of our two models is that genes of the first genome may be assigned two orthologs from the second genome, which has undergone a whole-genome duplication. Additionally, our models incorporate the new notion of duplication bonus, a parameter that reflects how assigning two orthologs to a given gene should be rewarded or penalized...
March 14, 2018: Computational Biology and Chemistry
Brian L Venables, Ny Sin, Alan Xiangdong Wang, Li-Qiang Sun, Yong Tu, Dennis Hernandez, Amy Sheaffer, Min Lee, Cindy Dunaj, Guangzhi Zhai, Diana Barry, Jacques Friborg, Fei Yu, Jay Knipe, Jason Sandquist, Paul Falk, Dawn Parker, Andrew C Good, Ramkumar Rajamani, Fiona McPhee, Nicholas A Meanwell, Paul M Scola
A series of tripeptidic acylsulfonamide inhibitors of HCV NS3 protease were prepared that explored structure-activity relationships (SARs) at the P4 position, and their in vitro and in vivo properties were evaluated. Enhanced potency was observed in a series of P4 ureas; however, the PK profiles of these analogues were less than optimal. In an effort to overcome the PK shortcomings, modifications to the P3-P4 junction were made. This included a strategy in which one of the two urea N-H groups was either N-methylated or replaced with an oxygen atom...
April 5, 2018: Bioorganic & Medicinal Chemistry Letters
Anne H Y Chu, Sheryl H X Ng, David Koh, Falk Müller-Riemenschneider
This study examined the validity and reliability of a domain-specific Adult Sedentary Behaviour Questionnaire (ASBQ) and the Global Physical Activity Questionnaire (GPAQ) single-item sitting question using self- and interviewer-administered modes of administration against the triaxial ActiGraph wGT3X-BT accelerometer. The ASBQ and the GPAQ were administered twice, seven days apart. Participants were asked to put on the waist-worn accelerometer for seven days. Convergent validity was assessed using Spearman's rho, mean absolute error (MAE), and Bland-Altman analysis ( n = 78)...
April 12, 2018: International Journal of Environmental Research and Public Health
Nico S Stumpp, Sarah A Konze, Rita Gerardy-Schahn, Meike Stiesch, Falk F R Buettner
Aggregatibacter (A.) actinomycetemcomitans is a periodontopathogenic bacterium causing aggressive periodontitis. Here we describe a single-step transconjugation system as novel and easily applicable protocol for site-specific genetic manipulation of A. actinomycetemcomitans. Deletion of PgaC, which is involved in the synthesis of biofilm matrix, led to a reduced biofilm formation.
April 5, 2018: Journal of Microbiological Methods
Xi Zhu, Xiaofei Du, Mike Kerich, Falk W Lohoff, Reza Momenan
Currently, classification of alcohol use disorder (AUD) is made on clinical grounds; however, robust evidence shows that chronic alcohol use leads to neurochemical and neurocircuitry adaptations. Identifications of the neuronal networks that are affected by alcohol would provide a more systematic way of diagnosis and provide novel insights into the pathophysiology of AUD. In this study, we identified network-level brain features of AUD, and further quantified resting-state within-network, and between-network connectivity features in a multivariate fashion that are classifying AUD, thus providing additional information about how each network contributes to alcoholism...
April 4, 2018: Neuroscience Letters
Nicole J Lake, Bryn D Webb, David A Stroud, Tara R Richman, Benedetta Ruzzenente, Alison G Compton, Hayley S Mountford, Juliette Pulman, Coralie Zangarelli, Marlene Rio, Nathalie Boddaert, Zahra Assouline, Mingma D Sherpa, Eric E Schadt, Sander M Houten, James Byrnes, Elizabeth M McCormick, Zarazuela Zolkipli-Cunningham, Katrina Haude, Zhancheng Zhang, Kyle Retterer, Renkui Bai, Sarah E Calvo, Vamsi K Mootha, John Christodoulou, Agnes Rötig, Aleksandra Filipovska, Ingrid Cristian, Marni J Falk, Metodi D Metodiev, David R Thorburn
No abstract text is available yet for this article.
April 5, 2018: American Journal of Human Genetics
Christina Dal Magro, Patrick Keller, Annika Kotter, Stephan Werner, Victor Duarte, Virginie Marchand, Michael Ignarski, Anja Freiwald, Roman-Ulrich Müller, Christoph Dieterich, Yuri Motorin, Falk Butter, Mohammed Atta, Mark Helm
Recently discovered new chemical entities in RNA modifications have provided surprises with respect to functional groups that enlarge the chemical space of RNA. Using LC-MS, we found over one hundred signals of RNA constituents that contained a ribose moiety in tRNAs from E. coli. Feeding experiments with variegated stable isotope labeled compounds identified 37 compounds, representing new structures of RNA modifications. One structure was elucidated by deuterium exchange and high resolution mass spectrometry...
April 6, 2018: Angewandte Chemie
Peter Falk, Andreas Jonsson, Torbjörn Swartling, Dan Asplund, Marie-Lois Ivarsson
Colorectal cancer is one of the most common forms of cancer. Spread of tumour to the peritoneal cavity may lead to seeding of cancer cells that adhere to and invade the peritoneal membrane causing peritoneal carcinomatosis. Matrix metalloproteinases (MMPs) play an essential role in cancer cell invasion and dissemination. The aim of this study was to evaluate the morphology and presence of matrix metalloproteinases in peritoneal carcinomatosis. Biopsy samples of the parietal peritoneum were taken from patients undergoing cytoreductive surgery for peritoneal carcinomatosis...
April 5, 2018: Medical Oncology
Cyril Charbonnel, Oleh Rymarenko, Olivier Da Ines, Fatiha Benyahya, Charles I White, Falk Butter, Simon Amiard
Despite intensive searches, few proteins involved in telomere homeostasis have been identified in plants. Here, we used pull-down assays to identify potential telomeric interactors in the model plant species Arabidopsis (Arabidopsis thaliana). We identified the candidate protein GH1-HMGA1 (also known as HON4), an uncharacterised linker histone protein of the high mobility group protein A (HMGA) family in plants. HMGAs are architectural transcription factors and have been suggested to function in DNA damage repair, but their precise biological roles remain unclear...
April 5, 2018: Plant Physiology
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