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https://www.readbyqxmd.com/read/28524817/functional-dissociation-of-stimulus-intensity-encoding-and-predictive-coding-of-pain-in-the-insula
#1
Stephan Geuter, Sabrina Boll, Falk Eippert, Christian Büchel
The computational principles by which the brain creates a painful experience from nociception are still unknown. Classic theories suggest that cortical regions either reflect stimulus intensity or additive effects of intensity and expectations, respectively. By contrast, predictive coding theories provide a unified framework explaining how perception is shaped by the integration of beliefs about the world with mismatches resulting from the comparison of these believes against sensory input. Using functional magnetic resonance imaging during a probabilistic heat pain paradigm, we investigated which computations underlie pain perception...
May 19, 2017: ELife
https://www.readbyqxmd.com/read/28521251/the-protective-effect-of-character-maturity-in-child-aggressive-antisocial-behavior
#2
Nóra Kerekes, Örjan Falk, Sven Brändström, Henrik Anckarsäter, Maria Råstam, Björn Hofvander
BACKGROUND: Childhood aggressive antisocial behavior (CD) is one of the strongest predictors of mental health problems and criminal behavior in adulthood. The aims of this study were to describe personality profiles in children with CD, and to determine the strength of association between defined neurodevelopmental symptoms, dimensions of character maturity and CD. METHODS: A sample of 1886 children with a close to equal distribution of age (9 or 12) and gender, enriched for neurodevelopmental and psychiatric problems were selected from the nationwide Child and Adolescent Twin Study in Sweden...
April 29, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28521118/automated-cassette-based-production-of-high-specific-activity-203-212-pb-peptide-based-theranostic-radiopharmaceuticals-for-image-guided-radionuclide-therapy-for-cancer
#3
Mengshi Li, Xiuli Zhang, Thomas P Quinn, Dongyoul Lee, Dijie Liu, Falk Kunkel, Brian E Zimmerman, Daniel McAlister, Keith Olewein, Yusuf Menda, Saed Mirzadeh, Roy Copping, Frances L Johnson, Michael K Schultz
A method for preparation of Pb-212 and Pb-203 labeled chelator-modified peptide-based radiopharmaceuticals for cancer imaging and radionuclide therapy has been developed and adapted for automated clinical production. Pre-concentration and isolation of radioactive Pb2+ from interfering metals in dilute hydrochloric acid was optimized using a commercially-available Pb-specific chromatography resin packed in disposable plastic columns. The pre-concentrated radioactive Pb2+ is eluted in NaOAc buffer directly to the reaction vessel containing chelator-modified peptides...
May 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28513882/imaging-nanoscale-morphology-of-semiconducting-polymer-films-with-photoemission-electron-microscopy
#4
Andreas Neff, Falk Niefind, Bernd Abel, Stefan C B Mannsfeld, Katrin R Siefermann
Photoemission electron microscopy in combination with polarized laser light is presented as a tool permitting direct imaging of polymer-chain orientation and local degree of order in semicrystalline samples of semiconducting polymers, a promising class of materials for future electronics. The key advantages of this imaging tool are its nondestructive and fast measurements, straightforward data analysis, the low complexity of sample preparation, and the possibility of performing measurements on a broad variety of technologically relevant substrates...
May 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28511968/the-future-of-image-guided-radiotherapy
#5
EDITORIAL
A Choudhury, G Budgell, R MacKay, S Falk, C Faivre-Finn, M Dubec, M van Herk, A McWilliam
No abstract text is available yet for this article.
May 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28511612/ngs-analysis-on-tumor-tissue-and-cfdna-for-genotype-directed-therapy-in-metastatic-nsclc-patients-between-hope-and-hype
#6
Alexander T Falk, Simon Heeke, Véronique Hofman, Virginie Lespinet, Camille Ribeyre, Olivier Bordone, Michel Poudenx, Josiane Otto, Georges Garnier, Olivier Castelnau, Joël Guigay, Sylvie Leroy, Charles-Hugo Marquette, Paul Hofman, Marius Ilié
The advent of genomic based precision medicine led to the implementation of biomarker testing in metastatic non-small cell lung cancer (NSCLC) patients. Next generation sequencing (NGS) has been recently implemented to routine diagnostic requirements in lung oncology. Areas covered: Two cases of patients with metastatic NSCLC for whom NGS analysis performed on both tumor and liquid biopsy has not improved the clinical course of their disease are reported. These cases illustrate the difficulty of the so-called "personalized or precision" medicine in clinical routine practice for metastatic NSCLC...
May 17, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28509371/quantitative-assessment-of-sialo-glycoproteins-and-n-glycans-during-cardiomyogenic-differentiation-of-human-induced-pluripotent-stem-cells
#7
Sarah Anna Konze, Samanta Cajic, Astrid Oberbeck, René Hennig, Andreas Pich, Erdmann Rapp, Falk Buettner
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) may be used in regenerative medicine for individualized tissue transplants in future. For application in patients, the generated CMs have to be highly pure and well characterized. To overcome the prevalent scarcity of CM-specific markers, we quantitatively assessed cell surface exposed sialo-glycoproteins and N-glycans of hiPSCs, CM progenitors and CMs derived thereof. Applying a combination of metabolic labeling and specific sialo-glycoprotein capture, we could highly enrich and quantify membrane proteins during cardiomyogenic differentiation...
May 16, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28507331/mycoviruses-of-an-endophytic-fungus-can-replicate-in-plant-cells-evolutionary-implications
#8
L Nerva, G C Varese, B W Falk, M Turina
So far there is no record of a specific virus able to infect both fungal and plant hosts in nature. However, experimental evidence shows that some plant virus RdRPs are able to perform replication in trans of genomic or DI RNAs in the yeast Saccharomyces cerevisiae. Furthermore, tobacco mosaic virus was recently shown to replicate in a filamentous ascomycetous fungus. Thus, at least experimentally, some plant viruses can infect some fungi. Endophytic fungi have been reported from many plants and several of these fungi have been shown to contain viruses...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28504911/the-value-of-sharing-information-a-neural-account-of-information-transmission
#9
Elisa C Baek, Christin Scholz, Matthew Brook O'Donnell, Emily B Falk
Humans routinely share information with one another. What drives this behavior? We used neuroimaging to test an account of information selection and sharing that emphasizes inherent reward in self-reflection and connecting with other people. Participants underwent functional MRI while they considered personally reading and sharing New York Times articles. Activity in neural regions involved in positive valuation, self-related processing, and taking the perspective of others was significantly associated with decisions to select and share articles, and scaled with preferences to do so...
May 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28503719/radiation-and-depression-associated-with-complications-of-tissue-expander-reconstruction
#10
Paul J Chuba, William A Stefani, Carrie Dul, Susan Szpunar, Jeffrey Falk, Rachael Wagner, Elango Edhayan, Anna Rabbani, Cynthia H Browne, Amr Aref
PURPOSE: Rates of implant failure, wound healing delay, and infection are higher in patients having radiation therapy (RT) after tissue expander (TE) and permanent implant reconstruction. We investigated pretreatment risk factors for TE implant complications. PATIENTS AND METHODS: 127 breast cancer patients had TE reconstruction and radiation. For 85 cases of bilateral TE reconstruction, the non-irradiated breast provided an internal control. Comparison of differences in means for continuous variables used analysis of variance, then multiple pairwise comparisons with Bonferroni correction of p value...
May 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28501945/macrophage-polarization-differs-between-apical-granulomas-radicular-cysts-and-dentigerous-cysts
#11
Manuel Weber, Tilo Schlittenbauer, Patrick Moebius, Maike Büttner-Herold, Jutta Ries, Raimund Preidl, Carol-Immanuel Geppert, Friedrich W Neukam, Falk Wehrhan
OBJECTIVES: Apical periodontitis can appear clinically as apical granulomas or radicular cysts. There is evidence that immunologic factors are involved in the pathogenesis of both pathologies. In contrast to radicular cysts, the dentigerous cysts have a developmental origin. Macrophage polarization (M1 vs M2) is a main regulator of tissue homeostasis and differentiation. There are no studies comparing macrophage polarization in apical granulomas, radicular cysts, and dentigerous cysts...
May 13, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28500257/zbtb48-is-both-a-vertebrate-telomere-binding-protein-and-a-transcriptional-activator
#12
Arne Jahn, Grishma Rane, Maciej Paszkowski-Rogacz, Sergi Sayols, Alina Bluhm, Chung-Ting Han, Irena Draškovič, José Arturo Londoño-Vallejo, Alan Prem Kumar, Frank Buchholz, Falk Butter, Dennis Kappei
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated by the CST complex and HOT1/HMBOX1, while subtelomeric variant repeats are recognized by NR2C/F transcription factors. Recently, the Kruppel-like zinc finger protein ZBTB48/HKR3/TZAP has been described as a novel telomere-associated factor in the vertebrate lineage...
May 12, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28499667/insight-into-the-incidence-of-acute-aortic-dissection-in-the-german-region-of-berlin-and-brandenburg
#13
S D Kurz, V Falk, J Kempfert, M Gieb, T M Ruschinski, M Kukucka, M Tsokos, H Grubitzsch, H Herbst, J Semmler, C Buschmann
BACKGROUND: Stanford acute type A aortic dissection (ATAAD) is a potentially lethal condition. Epidemiology studies show a statistical incidence in Europe of approximately 2-16 cases/100,000 inhabitants/year. In Germany, the estimated incidence (here subsumed under "thoracic aortic dissection" with 4.63 cases/100,000 inhabitants/year) is mainly extracted from medical death certificates by the German Federal Statistical Office. The prehospital incidence of ATAAD deaths is largely unknown...
May 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28498442/prognostic-significance-of-altered-mirna-expression-in-whole-blood-of-oscc-patients
#14
Jutta Ries, Christoph Baran, Falk Wehrhan, Manuel Weber, Friedrich W Neukam, Andrea Krautheim-Zenk, Emeka Nkenke
Currently, there is a lack of blood markers for the detection of recurrent oral squamous cell carcinoma (OSCC). The present study aimed to investigate whether the aberrant expression of single microRNAs (miRNAs) in whole blood of patients could serve as a biomarker for persistent or recurrent OSCC. Whole blood of 2 groups of formerly treated OSCC patients was investigated by RT-qPCR for their circulating miRNA profiles. The R-OC group included patients with recurrence of OSCC (n=21) and the NR-OC group included patients without recurrence (n=21)...
May 11, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28497232/tamoxifen-for-induction-of-cre-recombination-may-confound-fibrosis-studies-in-female-mice
#15
Lucas L Falke, Roel Broekhuizen, Alwin Huitema, Erik Maarseveen, Tri Q Nguyen, Roel Goldschmeding
A variety of conditional knock-out mice relying on Tamoxifen-driven ERT2/Cre -mediated recombination are available and have been used to study involvement of specific genes in kidney disease. However, recent data suggest that Tamoxifen itself might attenuate fibrosis when administered during experimental models of kidney disease. It has remained unclear whether this still applies also if kidney damage is initiated after a wash-out period has been implemented. Here we report that the commonly applied regimen of administration of 4 alternate day doses of 1mg Tamoxifen per mouse until 14 days prior to start of the actual experiment, in this case the induction of obstructive nephropathy by Unilateral Ureteral Obstruction (UUO), still attenuated fibrosis in female obstructed mouse kidneys, whereas this effect was not seen in male obstructed kidneys...
May 11, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28493490/the-protective-effect-of-humic-rich-substances-on-atypical-aeromonas-salmonicida-subsp-salmonicida-infection-in-common-carp-cyprinus-carpio-l
#16
G Yamin, R Falk, R R Avtalion, N Shoshana, T Ofek, R Smirnov, G Rubenstein, J van Rijn
When challenged with atypical Aeromonas salmonicida subsp. salmonicida, exposure of the common carp (Cyprinus carpio L.) to different humic-rich compounds resulted in a significant reduction in infection rates. Specifically, in fish exposed to (i) humic-rich water and sludge from a recirculating system, (ii) a synthetic humic acid, and (iii) a Leonardite-derived humic-rich extract, infection rates were reduced to 14.9%, 17.0% and 18.8%, respectively, as compared to a 46.8% infection rate in the control treatment...
May 11, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28493063/authors-reply-to-dotan-and-falk-are-prepubertal-children-metabolically-comparable-to-well-trained-adult-endurance-athletes
#17
Sébastien Ratel, Anthony J Blazevich
No abstract text is available yet for this article.
May 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28489955/isometric-and-dynamic-strength-and-neuromuscular-attributes-as-predictors-of-vertical-jump-performance-in-11%C3%A2-13-year-old-male-athletes
#18
Brandon John McKinlay, Phillip J Wallace, Raffy Dotan, Devon Long, Craig Tokuno, David A Gabriel, Bareket Falk
In explosive contractions, neural activation is a major factor in determining the rate of torque development, while the latter is an important determinant of jump performance. However, the contribution of neuromuscular activation and rate of torque development to jump performance in children and youth is unclear. PURPOSE: To examine the relationships between the rate of neuromuscular activation, peak torque, rate of torque development, and jump performance in young male athletes. METHODS: Forty-one 12...
May 10, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28488042/randomized-investigator-blinded-controlled-clinical-study-with-lice-shampoo-licener%C3%A2-versus-dimethicone-jacutin%C3%A2-pedicul-fluid-for-the-treatment-of-infestations-with-head-lice
#19
Margit Semmler, Fathy Abdel-Ghaffar, Falk Gestmann, Mohammed Abdel-Aty, Ibrahim Rizk, Saleh Al-Quraishy, Walter Lehmacher, Norman-Philipp Hoff
The present clinical trial was conducted to obtain additional data for the safety and efficacy of a head lice shampoo that is free of silicone compared with an anti-head lice product containing dimethicone. Both products act by a physical mode of action. This randomized, investigator-blinded, controlled clinical study was conducted between July and November 2016 in households of two villages (Abou Rawash and Shandalat) in Egypt. Children older than 2 years with an active head lice infestation were treated with either a shampoo-based head lice treatment containing neem extract (Licener®) or dimethicone (Jacutin® Pedicul Fluid) on day 1 and additionally on day 9...
May 9, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28488021/striatal-reward-sensitivity-predicts-therapy-related-neural-changes-in-alcohol-addiction
#20
Alena Becker, Martin Fungisai Gerchen, Martina Kirsch, Sabine Hoffmann, Falk Kiefer, Peter Kirsch
Individual differences in reward sensitivity along with weakened executive control are characteristic for alcohol use disorder (AUD). Emerging translational models of psychotherapy propose the integration of such neurobiological risk profiles to elucidate the mechanisms underlying behavior change in order to improve intervention efficacy. The primary aim of the study was to investigate whether striatal baseline reward sensitivity can be used as a neurobiological predictor of intervention-specific changes in neural functioning during AUD therapy...
May 9, 2017: European Archives of Psychiatry and Clinical Neuroscience
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