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https://www.readbyqxmd.com/read/29236051/synchrotron-based-pencil-beam-scanning-nozzle-with-an-integrated-mini-ridge-filter-a-dosimetric-study-to-optimize-treatment-delivery
#1
Xianliang Wang, Yupeng Li, Xiaodong Zhang, Heng Li, Koichi Miyazaki, Rintaro Fujimoto, Hiroshi Akiyama, Michael T Gillin, Falk Poenisch, Narayan Sahoo, David Grosshans, Brandon Gunn, Steven Jay Frank, Pei Wang, Jinyi Lang, Qing Hou, Xiaorong Ronald Zhu
A mini-ridge filter is often used to widen the Bragg peak in the longitudinal direction at low energies but not high energies. To facilitate the clinical use of a mini-ridge filter, we performed a planning study for the feasibility of a mini-ridge filter as an integral part of the synchrotron nozzle (IMRF). Dose models with and without IMRF were commissioned in a commercial Treatment planning system (TPS). Dosimetric characteristics in a homogenous water phantom were compared between plans with and without IMRF for a fixed spread-out Bragg peak width of 4 cm with distal ranges varying from 8 to 30 g/cm²...
December 13, 2017: Cancers
https://www.readbyqxmd.com/read/29235724/electrobiorefineries-unlocking-the-synergy-of-electrochemical-and-microbial-conversions
#2
Falk Harnisch, Carolin Urban
Lead-in: An integrated biobased economy urges an alliance of the two realms "chemical production" and "electric power". The concept of electrobiorefineries provides a blueprint for such an alliance agreement. Joining the forces of microbial and electrochemical conversions in electrobiorefineries allows interfacing the production, storage, and exploitation of electricity as well as biobased chemicals. Electrobiorefineries are a technological evolution of biorefineries by means of the addition of (bio)electrochemical transformations...
December 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29235567/alcohol-and-oestrogen-metabolites-in-postmenopausal-women-in-the-women-s-health-initiative-observational-study
#3
Mary C Playdon, Sally B Coburn, Steven C Moore, Louise A Brinton, Nicolas Wentzensen, Garnet Anderson, Robert Wallace, Roni T Falk, Ruth Pfeiffer, Xia Xu, Britton Trabert
BACKGROUND: Alcohol consumption is associated with an increased risk of several cancers. Potential mechanisms include altered oestrogen metabolism. Parent oestrogens metabolise into alternate pathways of oestrogen metabolites that may have variable effects on cancer pathogenesis. We examined associations of alcohol consumption with circulating oestrogen/oestrogen metabolites in postmenopausal women in the Women's Health Initiative (WHI)-Observational Study (OS). METHODS: We conducted a cross-sectional analysis of prediagnosis ovarian/endometrial cancer case-control data within WHI-OS (N=1864)...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29234942/does-hiatal-repair-affect-gastroesophageal-reflux-symptoms-in-patients-undergoing-laparoscopic-sleeve-gastrectomy
#4
Philip Le Page, David Martin, Craig Taylor, Jennifer Wang, Himanshu Wadhawan, Gregory Falk, Simon C Gibson
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained popularity as a treatment of choice for morbid obesity and associated comorbidities. There has been a concern about new onset or worsening of gastroesophageal reflux (GERD) following LSG. OBJECTIVE: The objective of the study was to evaluate the effect of surgically treating hiatal weakness on GERD symptoms in patients undergoing LSG. SETTING: Single tertiary referral institution, Sydney, Australia...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29233216/nucleic-acids-function-and-potential-for-abiogenesis
#5
Falk Wachowius, James Attwater, Philipp Holliger
The emergence of functional cooperation between the three main classes of biomolecules - nucleic acids, peptides and lipids - defines life at the molecular level. However, how such mutually interdependent molecular systems emerged from prebiotic chemistry remains a mystery. A key hypothesis, formulated by Crick, Orgel and Woese over 40 year ago, posits that early life must have been simpler. Specifically, it proposed that an early primordial biology lacked proteins and DNA but instead relied on RNA as the key biopolymer responsible not just for genetic information storage and propagation, but also for catalysis, i...
January 2017: Quarterly Reviews of Biophysics
https://www.readbyqxmd.com/read/29230871/prospective-motion-correction-enables-highest-resolution-time-of-flight-angiography-at-7t
#6
Hendrik Mattern, Alessandro Sciarra, Frank Godenschweger, Daniel Stucht, Falk Lüsebrink, Georg Rose, Oliver Speck
PURPOSE: Higher magnetic field strengths enable time-of-flight (TOF) angiography with higher resolution to depict small-vessel pathologies. However, this potential is limited by the subject's ability to remain motionless. Even small-scale, involuntary motion can degrade vessel depiction, thus limiting the effective resolution. The aim of this study was to overcome this resolution limit by deploying prospectively motion-corrected (PMC) TOF. METHODS: An optical, marker-based, in-bore tracking system was used to update the imaging volume prospectively according to the subject's head motion...
December 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29221956/global-burden-of-molar-incisor-hypomineralization
#7
REVIEW
Falk Schwendicke, Karim Elhennawy, Seif Reda, Katrin Bekes, David J Manton, Joachim Krois
OBJECTIVES: We aimed to systematically review and meta-analyze the global, super-regional, regional and national prevalence of molar-incisor-hypomineralization (MIH) and to determine the numbers of prevalent and incident cases on different spatial scales. The review was registered (PROSPERO CRD42017063842). SOURCES: Five electronic databases (Medline, EMBASE, LILACS, Web of Science, Google Scholar) were searched systematically. STUDY SELECTION: Observational studies on the prevalence of MIH were included and the prevalence on different spatial scales (global, super-regional, regional, national) synthesized using random-effects meta-analyses...
December 5, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29220717/microbial-electricity-driven-anoxic-ammonium-removal
#8
Anna Vilajeliu-Pons, Christin Koch, Maria D Balaguer, Jesús Colprim, Falk Harnisch, Sebastià Puig
Removal of nitrogen, mainly in form of ammonium (NH4+), in wastewater treatment plants (WWTPs) is a highly energy demanding process, mainly due to aeration. It causes costs of about half a million Euros per year in an average European WWTP. Alternative, more economical technologies for the removal of nitrogen compounds from wastewater are required. This study proves the complete anoxic conversion of ammonium (NH4+) to dinitrogen gas (N2) in continuously operated bioelectrochemical systems at the litre-scale...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/29216651/regenerative-medicine-cardiac-cell-therapy-pluripotent-stem-cells
#9
Ana G Duran, Olivia Reidell, Harald Stachelscheid, Kristin Klose, Manfred Gossen, Volkmar Falk, Wilhelm Röll, Christof Stamm
No abstract text is available yet for this article.
December 7, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29215644/response-to-newman-et-al
#10
Sumit Parikh, Amy Goldstein, Amel Karaa, Mary Kay Koenig, Irina Anselm, Catherine Brunel-Guitton, John Christodoulou, Bruce H Cohen, David Dimmock, Gregory M Enns, Marni J Falk, Annette Feigenbaum, Richard E Frye, Jaya Ganesh, David Griesemer, Richard Haas, Rita Horvath, Mark Korson, Michael C Kruer, Michelangelo Mancuso, Shana McCormack, Marie Josee Raboisson, Tyler Reimschisel, Ramona Salvarinova, Russell P Saneto, Fernando Scaglia, John Shoffner, Peter W Stacpoole, Carolyn M Sue, Mark Tarnopolsky, Clara Van Karnebeek, Lynne A Wolfe, Zarazuela Zolkipli Cunningham, Shamima Rahman, Patrick F Chinnery
No abstract text is available yet for this article.
December 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29214281/equivalence-clarifications-required
#11
Falk Leichsenring
No abstract text is available yet for this article.
December 6, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29211993/single-molecule-study-reveals-how-receptor-and-ras-synergistically-activate-pi3k%C3%AE-and-pip3-signaling
#12
Thomas C Buckles, Brian P Ziemba, Glenn R Masson, Roger L Williams, Joseph J Falke
Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate specific isoforms of phosphatidylinositol-3-kinase (PI3K). These PI3K lipid kinases phosphorylate the constitutive lipid phosphatidylinositol-4,5-bisphosphate (PIP2) to produce the signaling lipid phosphatidylinositol-3,4,5-trisphosphate (PIP3). Progress has been made in understanding direct, moderate PI3K activation by receptors. In contrast, the mechanism by which receptors and Ras synergistically activate PI3K to much higher levels remains unclear, and two competing models have been proposed: membrane recruitment versus activation of the membrane-bound enzyme...
December 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29209791/electrification-of-biotechnology-status-quo
#13
Falk Harnisch, Dirk Holtmann
Interfacing microbial, enzymatic, and electrochemical transformations has led to the new field of electrobiotechnology. Among the plethora of applications (including electric energy generation via pollutant removal), the synthesis of chemicals and energy carriers (e.g. H2) has sparked great interest. The linked transformation of chemical and electric energy may allow the joint utilization of renewable feedstock and sustainable electricity to gain commodities and fuels. The overall field is now referred to as bioelectrosynthesis and is a focus of this book...
December 6, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29206961/corrigendum-to-2017-esc-eacts-guidelines-for-the-management-of-valvular-heart-disease-eur-j-cardiothorac-surg-2017-52-616-664
#14
Volkmar Falk, Helmut Baumgartner, Jeroen J Bax, Michele De Bonis, Christian Hamm, Per Johan Holm, Bernard Iung, Patrizio Lancellotti, Emmanuel Lansac, Daniel Rodriguez Muñoz, Raphael Rosenhek, Johan Sjögren, Pilar Tornos Mas, Alec Vahanian, Thomas Walther, Olaf Wendler, Stephan Windecker, Jose Luis Zamorano, Marco Roffi, Ottavio Alfieri, Stefan Agewall, Anders Ahlsson, Emanuele Barbato, Héctor Bueno, Jean-Philippe Collet, Ioan Mircea Coman, Martin Czerny, Victoria Delgado, Donna Fitzsimons, Thierry Folliguet, Oliver Gaemperli, Gilbert Habib, Wolfgang Harringer, Michael Haude, Gerhard Hindricks, Hugo A Katus, Juhani Knuuti, Philippe Kolh, Christophe Leclercq, Theresa A McDonagh, Massimo Francesco Piepoli, Luc A Pierard, Piotr Ponikowski, Giuseppe M C Rosano, Frank Ruschitzka, Evgeny Shlyakhto, Iain A Simpson, Miguel Sousa-Uva, Janina Stepinska, Giuseppe Tarantini, Didier Tchétché, Victor Aboyans
No abstract text is available yet for this article.
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29206593/glioma-grade-discrimination-with-mr-diffusion-kurtosis-imaging-a-meta-analysis-of-diagnostic-accuracy
#15
Anna Falk Delgado, Markus Nilsson, Danielle van Westen, Alberto Falk Delgado
Purpose To assess the diagnostic test accuracy and sources of heterogeneity for the discriminative potential of diffusion kurtosis imaging (DKI) to differentiate low-grade glioma (LGG) (World Health Organization [WHO] grade II) from high-grade glioma (HGG) (WHO grade III or IV). Materials and Methods The Cochrane Library, Embase, Medline, and the Web of Science Core Collection were systematically searched by two librarians. Retrieved hits were screened for inclusion and were evaluated with the revised tool for quality assessment for diagnostic accuracy studies (commonly known as QUADAS-2) by two researchers...
December 4, 2017: Radiology
https://www.readbyqxmd.com/read/29205338/s1p-receptor-antagonists-fingolimod-and-siponimod-do-not-improve-the-outcome-of-experimental-autoimmune-myasthenia-gravis-mice-after-disease-onset
#16
Andreas Pelz, Hanne Schaffert, Radharani Diallo, Falk Hiepe, Andreas Meisel, Siegfried Kohler
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and fatigue in the presence of circulating antibodies against components of the neuromuscular junction. Most patients have a good prognosis, but some are refractory to standard-of-care immunosuppressive treatment and suffer from recurrent myasthenic crises. Functional sphingosine-1-phosphate (S1P) antagonists like fingolimod and siponimod (BAF312) are successfully used for the treatment of multiple sclerosis, and fingolimod was shown to prevent the development of myasthenic symptoms in experimental autoimmune myasthenia gravis (EAMG), the standard model of MG...
December 4, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29204606/modeling-speech-level-as-a-function-of-background-noise-level-and-talker-to-listener-distance-for-talkers-wearing-hearing-protection-devices
#17
Rachel E Bouserhal, Annelies Bockstael, Ewen MacDonald, Tiago H Falk, Jérémie Voix
Purpose: Studying the variations in speech levels with changing background noise level and talker-to-listener distance for talkers wearing hearing protection devices (HPDs) can aid in understanding communication in background noise. Method: Speech was recorded using an intra-aural HPD from 12 different talkers at 5 different distances in 3 different noise conditions and 2 quiet conditions. Results: This article proposes models that can predict the difference in speech level as a function of background noise level and talker-to-listener distance for occluded talkers...
December 4, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29202938/prevalence-of-monoclonal-gammopathy-in-wild-type-transthyretin-amyloidosis
#18
Hallie I Geller, Avinainder Singh, Tara M Mirto, Robert Padera, Richard Mitchell, Jacob P Laubach, Rodney H Falk
OBJECTIVE: To evaluate the prevalence of monoclonal gammopathy (MG) in patients with wild-type transthyretin amyloidosis (ATTRwt) (formerly known as senile amyloidosis). PATIENTS AND METHODS: We retrospectively analyzed the serum protein electrophoresis and serum immunofixation results, free light chain (FLC) levels, and renal function of 113 consecutive patients with ATTRwt seen at the Brigham and Women's Hospital's Cardiac Amyloidosis Program between February 21, 2006, and November 9, 2016...
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29198579/determination-of-vegf-collagen-type-1-and-versican-in-the-discus-articularis-of-the-temporomandibular-joint-in-relation-to-dental-status
#19
Malte Michaelis, Ralph Lucius, Jörg Wiltfang, Falk Birkenfeld
The aim of this study was the investigation and comparison of the presence of vascular endothelial growth factor (VEGF), collagen type 1 and the proteoglycan versican in the discus articularis in relation to dental status (full dentition [1], partial dentition [2] and edentulous [3]). The right disci articulares were removed from 17 donated bodies (6 with full dentition, 5 with partial dentition and 6 edentulous). The specimens were immunohistochemically stained for VEGF, collagen type 1 and versican. Semiquantitative analysis of the disci was conducted within the groups based on the intensity of immunoreactivity of VEGF, collagen type 1 and versican...
September 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29197366/characteristics-and-outcome-in-patients-with-non-specific-symptoms-and-signs-of-cancer-referred-to-a-fast-track-cancer-patient-pathway-a-retrospective-cohort-study
#20
Sara Falk Jørgensen, Pernille Ravn, Søren Thorsen, Signe Westring Worm
BACKGROUND: In 2012 a new cancer patient pathway for patients with non-specific symptoms and signs of cancer (NSSC-CPP) was introduced in Denmark. Limited information is available about the patients referred to the NSSC-CPP and the investigational course. The aim was to describe the population and the investigational course, estimate the prevalence of cancer and one-year mortality, and identify factors associated with a subsequent cancer diagnosis in patients referred to the NSSC-CPP...
December 2, 2017: BMC Cancer
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