keyword
MENU ▼
Read by QxMD icon Read
search

Falk

keyword
https://www.readbyqxmd.com/read/28729366/recommendation-on-design-execution-and-reporting-of-animal-atherosclerosis-studies-a-scientific-statement-from-the-american-heart-association
#1
REVIEW
Alan Daugherty, Alan R Tall, Mat J A P Daemen, Erling Falk, Edward A Fisher, Guillermo García-Cardeña, Aldons J Lusis, A Phillip Owens, Michael E Rosenfeld, Renu Virmani
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies...
July 20, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28729353/recommendation-on-design-execution-and-reporting-of-animal-atherosclerosis-studies-a-scientific-statement-from-the-american-heart-association
#2
REVIEW
Alan Daugherty, Alan R Tall, Mat J A P Daemen, Erling Falk, Edward A Fisher, Guillermo García-Cardeña, Aldons J Lusis, A Phillip Owens, Michael E Rosenfeld, Renu Virmani
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies...
July 20, 2017: Circulation Research
https://www.readbyqxmd.com/read/28727848/the-nuclear-proteome-of-trypanosoma-brucei
#3
Carina Goos, Mario Dejung, Christian J Janzen, Falk Butter, Susanne Kramer
Trypanosoma brucei is a protozoan flagellate that is transmitted by tsetse flies into the mammalian bloodstream. The parasite has a huge impact on human health both directly by causing African sleeping sickness and indirectly, by infecting domestic cattle. The biology of trypanosomes involves some highly unusual, nuclear-localised processes. These include polycistronic transcription without classical promoters initiated from regions defined by histone variants, trans-splicing of all transcripts to the exon of a spliced leader RNA, transcription of some very abundant proteins by RNA polymerase I and antigenic variation, a switch in expression of the cell surface protein variants that allows the parasite to resist the immune system of its mammalian host...
2017: PloS One
https://www.readbyqxmd.com/read/28723960/a-validation-of-11-body-condition-indices-in-a-giant-snake-species-that-exhibits-positive-allometry
#4
Bryan G Falk, Ray W Snow, Robert N Reed
Body condition is a gauge of the energy stores of an animal, and though it has important implications for fitness, survival, competition, and disease, it is difficult to measure directly. Instead, body condition is frequently estimated as a body condition index (BCI) using length and mass measurements. A desirable BCI should accurately reflect true body condition and be unbiased with respect to size (i.e., mean BCI estimates should not change across different length or mass ranges), and choosing the most-appropriate BCI is not straightforward...
2017: PloS One
https://www.readbyqxmd.com/read/28722185/valsalva-maneuver-exacerbates-left-atrial-compression-in-patients-with-large-hiatal-hernia
#5
Christopher Naoum, Leonard Kritharides, Sonali R Gnanenthiran, David Martin, Gregory L Falk, John Yiannikas
INTRODUCTION: Hiatal hernia (HH) can cause left atrial (LA) compression and impair LA filling. We evaluated the cardiac effects of preload reduction and abdominal strain induced by Valsalva maneuver (VM) in large HH patients. METHODS: LA and left ventricular (LV) dimensions were measured using 2D transthoracic echocardiography at rest and during VM in HH patients (n=55, 70±10 years) and controls (n=22, 67±6 years). Biplane LV volumes (n=39) and mitral inflow pulse-wave Doppler parameters (n=27) were also evaluated...
July 18, 2017: Echocardiography
https://www.readbyqxmd.com/read/28716790/human-papillomavirus-prevalence-and-genotype-distribution-among-young-women-and-men-in-maputo-city-mozambique
#6
Viegas Edna Omar, Augusto Orvalho, Ismael Nália, Kaliff Malin, Lillsunde-Larsson Gabriella, Ramqvist Torbjörn, Nilsson Charlotta, Falk Kerstin, Osman Nafissa, Jani Ilesh Vindorai, Andersson Sören
OBJECTIVES: Human papillomavirus (HPV) is a well-known cause of cervical cancer, the second most frequent cancer in female African populations. This study aimed at determining the prevalence of HPV infections and the genotype distribution in young adults aged 18-24, in Maputo city, Mozambique, and to assess the suitability of commercially available HPV vaccines. METHODS: This cross-sectional study was conducted between 2009 and 2011 at a youth clinic in Maputo Central Hospital...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28715399/integration-free-derivation-of-human-induced-pluripotent-stem-cells-using-laminin-521-matrix
#7
Elias Uhlin, Ana Marin Navarro, Harriet Rönnholm, Kelly Day, Malin Kele, Anna Falk
Xeno-free and fully defined conditions are key parameters for robust and reproducible generation of homogenous human induced pluripotent stem (hiPS) cells. Maintenance of hiPS cells on feeder cells or undefined matrices are susceptible to batch variances, pathogenic contamination and risk of immunogenicity. Utilizing the defined recombinant human laminin 521 (LN-521) matrix in combination with xeno-free and defined media formulations reduces variability and allows for the consistent generation of hiPS cells...
July 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28715132/return-of-neonatal-cpap-resistance-the-medijet-device-family-examined-using-in-vitro-flow-simulations
#8
M Falk, S Donaldsson, B Jonsson, T Drevhammar
AIM: Medijet nasal continuous positive airway pressure (CPAP) generators are a family of devices developed from the Benveniste valve. Previous studies have shown that the in-vitro performance of the Medijet disposable generator was similar to the Neopuff resistor system. We hypothesised that resistance would be the main mechanism of CPAP generation in the Medijet disposable generator. METHODS: The in-vitro performance of the Medijet reusable and disposable systems, the Neopuff resistor system and the Benveniste and Infant Flow non-resistor systems were investigated using static and dynamic bench tests...
July 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28714907/genetic-contribution-to-alcohol-dependence-investigation-of-a-heterogeneous-german-sample-of-individuals-with-alcohol-dependence-chronic-alcoholic-pancreatitis-and-alcohol-related-cirrhosis
#9
Jens Treutlein, Josef Frank, Fabian Streit, Céline S Reinbold, Dilafruz Juraeva, Franziska Degenhardt, Liz Rietschel, Stephanie H Witt, Andreas J Forstner, Monika Ridinger, Jana Strohmaier, Norbert Wodarz, Helene Dukal, Jerome C Foo, Per Hoffmann, Stefan Herms, Stefanie Heilmann-Heimbach, Michael Soyka, Wolfgang Maier, Wolfgang Gaebel, Norbert Dahmen, Norbert Scherbaum, Bertram Müller-Myhsok, Susanne Lucae, Marcus Ising, Felix Stickel, Thomas Berg, Ulla Roggenbuck, Karl-Heinz Jöckel, Henrike Scholz, Ulrich S Zimmermann, Stephan Buch, Wolfgang H Sommer, Rainer Spanagel, Benedikt Brors, Sven Cichon, Karl Mann, Falk Kiefer, Jochen Hampe, Jonas Rosendahl, Markus M Nöthen, Marcella Rietschel
The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (puncorrected = 1.2 × 10(-6); pcorrected = 0.020). This was driven by the AD subsample...
July 17, 2017: Genes
https://www.readbyqxmd.com/read/28710646/-outpatient-emergency-treatment-of-nursing-home-residents-analysis-of-insurance-claims-data
#10
Insa Seeger, Andres Luque Ramos, Falk Hoffmann
BACKGROUND: Utilization of outpatient emergency services by nursing home residents is increasing; however, out of hours medical care (OOHC) in Germany has not yet been studied. OBJECTIVE: In Bremen the used billing codes enabled a comparison between the use of outpatient emergency care in the year before and the year after admission to a nursing home stratified by emergency departments and OOHC. MATERIAL AND METHODS: In this retrospective cohort study we used insurance claims data of residents in Bremen, who were insured in a large German statutory health insurance (DAK-Gesundheit)...
July 14, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28708883/impact-of-stage-management-and-recurrence-on-survival-rates-in-laryngeal-cancer
#11
Jesper Brandstorp-Boesen, Ragnhild Sørum Falk, Morten Boysen, Kjell Brøndbo
A retrospective, longitudinal study of 1,616 patients with primary laryngeal squamous cell carcinoma (LSCC) at a single center in Norway during 1983-2010 was undertaken to investigate overall survival, disease specific survival, disease-free survival, prognostic factors for overall survival, and impact of recurrence among all-stage laryngeal cancer patients over 15 years' follow-up. The prognostic impact of gender, age, smoking/alcohol, subsite, tumour, node and metastasis staging, period and modality of treatment were evaluated using Kaplan-Meier and Cox proportional hazard analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28703323/professional-oral-healthcare-for-preventing-nursing-home-acquired-pneumonia-a-cost-effectiveness-and-value-of-information-analysis
#12
Falk Schwendicke, Michael Stolpe, Frauke Müller
AIM: Professional oral healthcare (POHC) prevents nursing-home-acquired pneumonia (NHAP) and its related mortality. We assessed the cost-effectiveness of POHC versus no POHC (nPOHC) and the monetary value of eliminating uncertainty by future research. METHODS: German public-private-payer-perspective was adopted. A Markov-model was used, following Long-Term-Care residents from admission to death. Cost-effectiveness was estimated as Euro/disability-adjusted-life-year (DALY) using Monte-Carlo microsimulations...
July 13, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28700730/pediatric-autoimmune-hepatitis-shows-a-disproportionate-decline-of-regulatory-t-cells-in-the-liver-and-of-il-2-in-the-blood-of-patients-undergoing-therapy
#13
Jana Diestelhorst, Norman Junge, Jerome Schlue, Christine S Falk, Michael P Manns, Ulrich Baumann, Elmar Jaeckel, Richard Taubert
BACKGROUND & AIMS: The autoimmune hepatitis (AIH) is a chronic hepatitis driven by the adaptive immunity that affects all age groups. A functional and numerical regulatory T cell (Treg) defect has been reported in pediatric AIH (pAIH), while an intrahepatic increase in adult AIH (aAIH) patients has been detected in current research findings. METHODS: Therefore, we quantified the intrahepatic numbers of Treg, T and B cells, as well as serum cytokine levels before and during therapy in pAIH...
2017: PloS One
https://www.readbyqxmd.com/read/28698192/twenty-year-nationwide-trends-in-statin-utilization-and-expenditure-in-denmark
#14
Martin Bødtker Mortensen, Erling Falk, Morten Schmidt
No abstract text is available yet for this article.
July 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28696759/erratum-high-fidelity-bidirectional-nuclear-qubit-initialization-in-sic-phys-rev-lett-117-220503-2016
#15
Viktor Ivády, Paul V Klimov, Kevin C Miao, Abram L Falk, David J Christle, Krisztián Szász, Igor A Abrikosov, David D Awschalom, Adam Gali
This corrects the article DOI: 10.1103/PhysRevLett.117.220503.
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28696746/coherent-plasmon-and-phonon-plasmon-resonances-in-carbon-nanotubes
#16
Abram L Falk, Kuan-Chang Chiu, Damon B Farmer, Qing Cao, Jerry Tersoff, Yi-Hsien Lee, Phaedon Avouris, Shu-Jen Han
Carbon nanotubes provide a rare access point into the plasmon physics of one-dimensional electronic systems. By assembling purified nanotubes into uniformly sized arrays, we show that they support coherent plasmon resonances, that these plasmons couple to nanotube and substrate phonons, and that the resulting phonon-plasmon resonances have quality factors as high as 10. Because nanotube plasmons intensely strengthen electromagnetic fields and light-matter interactions, they provide a compelling platform for surface-enhanced spectroscopy and tunable optical devices at deep-subwavelength scales...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28695996/downregulation-of-genes-coding-for-core-rnai-components-and-disease-resistance-proteins-via-corresponding-micrornas-might-be-correlated-with-successful-smv-infection-in-soybean
#17
Duran Bao, Oyunchuluun Ganbaatar, Xiuqi Cui, Ruonan Yu, Wenhua Bao, Bryce W Falk, Hada Wuriyanghan
Plants protect themselves from virus infections by several different defense mechanisms. RNA interference (RNAi) is one prominent antiviral mechanism, which requires the participation of AGO (Argonaute) and Dicer/DCL (Dicer-like) proteins. Effector-triggered immunity (ETI) is an antiviral mechanism mediated by resistance (R) genes, most of which encode NBS-LRR family proteins. MicroRNAs (miRNAs) play important regulatory roles in plants, including regulation of host defenses. SMV (Soybean mosaic virus) is the most common virus in soybean and here we identified dozens of SMV-responsive miRNAs by microarray analysis in a SMV-susceptible soybean line...
July 11, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28694659/induction-of-chronic-cholestasis-without-liver-cirrhosis-creation-of-an-animal-model
#18
Felix Dondorf, René Fahrner, Michael Ardelt, Eleonora Patsenker, Felix Stickel, Uta Dahmen, Utz Settmacher, Falk Rauchfuß
AIM: To analyze time intervals of inflammation and regeneration in a cholestatic rat liver model. METHODS: In 36 Lewis rats, divided into six groups of 6 animals (postoperative observation periods: 1, 2, 3, 4, 6, 8 wk), the main bile duct was ligated with two ligatures and observed for the periods mentioned above. For laboratory evaluation, cholestasis parameters (bilirubin, γ-GT), liver cell parameters (ASAT, ALAT) and liver synthesis parameters (quick, albumin) were determined...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28691283/a-soft-total-artificial-heart-first-concept-evaluation-on-a-hybrid-mock-circulation
#19
Nicholas H Cohrs, Anastasios Petrou, Michael Loepfe, Maria Yliruka, Christoph M Schumacher, A Xavier Kohll, Christoph T Starck, Marianne Schmid Daners, Mirko Meboldt, Volkmar Falk, Wendelin J Stark
The technology of 3D-printing has allowed the production of entirely soft pumps with complex chamber geometries. We used this technique to develop a completely soft pneumatically driven total artificial heart from silicone elastomers and evaluated its performance on a hybrid mock circulation. The goal of this study is to present an innovative concept of a soft total artificial heart (sTAH). Using the form of a human heart, we designed a sTAH, which consists of only two ventricles and produced it using a 3D-printing, lost-wax casting technique...
July 10, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28690613/relb-steady-state-migratory-dendritic-cells-control-the-peripheral-pool-of-the-natural-foxp3-regulatory-t-cells
#20
Anja Döhler, Theresa Schneider, Ina Eckert, Eliana Ribechini, Nico Andreas, Marc Riemann, Boris Reizis, Falk Weih, Manfred B Lutz
Thymus-derived natural Foxp3(+) CD4(+) regulatory T cells (nTregs) play a key role in maintaining immune tolerance and preventing autoimmune disease. Several studies indicate that dendritic cells (DCs) are critically involved in the maintenance and proliferation of nTregs. However, the mechanisms how DCs manage to keep the peripheral pool at constant levels remain poorly understood. Here, we describe that the NF-κB/Rel family transcription factor RelB controls the frequencies of steady-state migratory DCs (ssmDCs) in peripheral lymph nodes and their numbers control peripheral nTreg homeostasis...
2017: Frontiers in Immunology
keyword
keyword
78690
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"