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https://www.readbyqxmd.com/read/28319600/early-and-late-factors-impacting-patient-and-graft-outcome-in-pediatric-liver-transplantation-summary-of-an-espghan-monothematic-conference
#1
Valérie A McLin, Upton Allen, Olivia Boyer, John Bucuvalas, Michele Colledan, Maria-Cristina Cuturi, Lorenzo d'Antiga, Dominique Debray, Antal Dezsofi, Jean de Ville de Goyet, Anil Dhawan, Ozlem Durmaz, Christine Falk, Sandy Feng, Björn Fischler, Stéphanie Franchi-Abella, Esteban Frauca, Rainer Ganschow, Stephen Gottschalk, Nedim Hadzic, Loreto Hierro, Simon Horslen, Stefan Hubscher, Vincent Karam, Deirdre Kelly, Britta Maecker-Kolhoff, George Mazariegos, Patrick McKiernan, Anette Melk, Valerio Nobili, Funda Ozgenç, Raymond Reding, Marco Sciveres, Khalid Sharif, Piotr Socha, Christian Toso, Pietro Vajro, Anita Verma, Barbara E Wildhaber, Ulrich Baumann
As pediatric liver transplantation comes of age, experts gathered to discuss current paradigms and define gaps in knowledge warranting research to further improve patient and graft outcomes. Identified areas ripe for collaborative research include understanding the molecular and cellular mechanisms of tolerance and the role of donor-specific antibodies, considering ways to expand donor pool, minimizing long term side effects of immunosuppression, and fine-tuning surgical techniques to minimize biliary and vascular complications...
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28317282/cardiorespiratory-fitness-and-risk-of-site-specific-cancers-a%C3%A2-long-term-prospective-cohort-study
#2
Trude E Robsahm, Ragnhild S Falk, Trond Heir, Leiv Sandvik, Linda Vos, Jan Erikssen, Steinar Tretli
Based on self-reported physical activity, there is epidemiologic evidence for a beneficial relation between physical activity and colon cancer in men, but findings for other cancers are inconclusive. Measured cardiorespiratory fitness (CRF) can provide knowledge about the cancer-preventive value of physical activity. We aimed to assess relationships between CRF and risk of site-specific cancers. A cohort of 1997 healthy Norwegian men, aged 40-59 years at inclusion in 1972-1975, was followed for cancer throughout 2012 using data from the Cancer Registry of Norway...
March 20, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28317230/cortical-surface-based-threshold-free-cluster-enhancement-and-cortexwise-mediation
#3
Tristram A Lett, Lea Waller, Heike Tost, Ilya M Veer, Arash Nazeri, Susanne Erk, Eva J Brandl, Katrin Charlet, Anne Beck, Sabine Vollstädt-Klein, Anne Jorde, Falk Kiefer, Andreas Heinz, Andreas Meyer-Lindenberg, M Mallar Chakravarty, Henrik Walter
Threshold-free cluster enhancement (TFCE) is a sensitive means to incorporate spatial neighborhood information in neuroimaging studies without using arbitrary thresholds. The majority of methods have applied TFCE to voxelwise data. The need to understand the relationship among multiple variables and imaging modalities has become critical. We propose a new method of applying TFCE to vertexwise statistical images as well as cortexwise (either voxel- or vertexwise) mediation analysis. Here we present TFCE_mediation, a toolbox that can be used for cortexwise multiple regression analysis with TFCE, and additionally cortexwise mediation using TFCE...
March 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28315862/the-evolving-role-of-rituximab-in-adult-minimal-change-glomerulopathy
#4
Landon C Brown, Meghan A Jobson, Fernanda Payan Schober, Emily H Chang, Ronald J Falk, Patrick H Nachman, William F Pendergraft
BACKGROUND: Minimal-change glomerulopathy is defined histologically by the presence of normal glomeruli on light microscopy and diffuse podocyte effacement on electron microscopy. Although effective in children, corticosteroid treatment in adults is more variable and time to response can be prolonged. Data to support rituximab use in adults with corticosteroid-dependent or resistant minimal-change glomerulopathy are limited. Here, we describe the clinical course of adults with corticosteroid-dependent or -resistant minimal-change glomerulopathy who received rituximab...
March 18, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28303425/common-data-elements-for-clinical-research-in-mitochondrial-disease-a-national-institute-for-neurological-disorders-and-stroke-project
#5
Amel Karaa, Shamima Rahman, Anne Lombès, Patrick Yu-Wai-Man, Muniza K Sheikh, Sherita Alai-Hansen, Bruce H Cohen, David Dimmock, Lisa Emrick, Marni J Falk, Shana McCormack, David Mirsky, Tony Moore, Sumit Parikh, John Shoffner, Tanja Taivassalo, Mark Tarnopolsky, Ingrid Tein, Joanne C Odenkirchen, Amy Goldstein
OBJECTIVES: The common data elements (CDE) project was developed by the National Institute of Neurological Disorders and Stroke (NINDS) to provide clinical researchers with tools to improve data quality and allow for harmonization of data collected in different research studies. CDEs have been created for several neurological diseases; the aim of this project was to develop CDEs specifically curated for mitochondrial disease (Mito) to enhance clinical research. METHODS: Nine working groups (WGs), composed of international mitochondrial disease experts, provided recommendations for Mito clinical research...
March 16, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28300153/brucella-spp-of-amphibians-comprise-genomically-diverse-motile-strains-competent-for-replication-in-macrophages-and-survival-in-mammalian-hosts
#6
Sascha Al Dahouk, Stephan Köhler, Alessandra Occhialini, María Pilar Jiménez de Bagüés, Jens Andre Hammerl, Tobias Eisenberg, Gilles Vergnaud, Axel Cloeckaert, Michel S Zygmunt, Adrian M Whatmore, Falk Melzer, Kevin P Drees, Jeffrey T Foster, Alice R Wattam, Holger C Scholz
Twenty-one small Gram-negative motile coccobacilli were isolated from 15 systemically diseased African bullfrogs (Pyxicephalus edulis), and were initially identified as Ochrobactrum anthropi by standard microbiological identification systems. Phylogenetic reconstructions using combined molecular analyses and comparative whole genome analysis of the most diverse of the bullfrog strains verified affiliation with the genus Brucella and placed the isolates in a cluster containing B. inopinata and the other non-classical Brucella species but also revealed significant genetic differences within the group...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299900/development-of-a-robust-mammalian-cell-based-assay-for-studying-recombinant-%C3%AE-4-%C3%AE-1-3-%C3%AE-gabaa-receptor-subtypes
#7
Christina B Falk-Petersen, Rikke Søgaard, Kenneth L Madsen, Anders B Klein, Bente Frølund, Petrine Wellendorph
δ-Containing GABAA receptors are located extrasynaptically and mediate tonic inhibition. Their involvement in brain physiology positions them as interesting drug targets. There is thus a continued interest in establishing reliable recombinant expression systems for δ-containing GABAA receptors. Inconveniently, the recombinant expression of especially α4 β1/3 δ receptors has been found to be notoriously difficult, due to mixed receptor populations and/or stoichiometries and differential pharmacology depending on the expression system used...
March 16, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28298156/a-new-admission-method-may-select-applicants-with-a-distinct-personality-profile
#8
Aya G Talmor, Amir Falk, Yaniv Almog
BACKGROUND: There is little data to suggest that a specific admission method can select students with a distinct personality profile. We have recently introduced a new admission process that combines a computerized personality test, with a single interview. The purpose of the current study was to find whether the new method selects applicants with a different personality profile and attitudes compared with the previous method. METHOD: Using a validated personality questionnaire (HEXACO) and attitudes questionnair, that were filled anonymously between November 2014 and May 2015, the authors compared two groups of students: group A comprising students accepted with the new method (first and second year) with group B comprising students accepted with the previous method (third to sixth year)...
March 15, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28297737/qualit%C3%A3-tssicherung-in-der-lehre-%C3%A2-entwicklung-und-analyse-von-checklisten-zur-beurteilung-von-lehrvideos-zum-erlernen-praktischer-fertigkeiten
#9
Miriam Rüsseler, Jasmina Sterz, Phaedra Kalozoumi-Paisi, Anna Schill, Bernd Bender, Sebastian H Hoefer, Iris Schleicher, Alexander I Damankis, Dennis Josephs, Falk Ochsendorf, Christina Stefanescu, Holger Hoffmann, Teresa Schreckenbach, Felix Walcher
No abstract text is available yet for this article.
February 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28297453/spot-scanning-proton-therapy-minimizes-neutron-dose-in-the-setting-of-radiation-therapy-administered-during-pregnancy
#10
Xin Wang, Falk Poenisch, Narayan Sahoo, Ronald X Zhu, MingFwu Lii, Michael T Gillin, Jing Li, David Grosshans
This is a real case study to minimize the neutron dose equivalent (H) to a fetus using spot scanning proton beams with favorable beam energies and angles. Minimum neutron dose exposure to the fetus was achieved with iterative planning under the guidance of neutron H measurement. Two highly conformal treatment plans, each with three spot scanning beams, were planned to treat a 25-year-old pregnant female with aggressive recurrent chordoma of the base of skull who elected not to proceed with termination. Each plan was scheduled for delivery every other day for robust target coverage...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296966/an-oral-multispecies-biofilm-model-for-high-content-screening-applications
#11
Nadine Kommerein, Sascha N Stumpp, Mathias Müsken, Nina Ehlert, Andreas Winkel, Susanne Häussler, Peter Behrens, Falk F R Buettner, Meike Stiesch
Peri-implantitis caused by multispecies biofilms is a major complication in dental implant treatment. The bacterial infection surrounding dental implants can lead to bone loss and, in turn, to implant failure. A promising strategy to prevent these common complications is the development of implant surfaces that inhibit biofilm development. A reproducible and easy-to-use biofilm model as a test system for large scale screening of new implant surfaces with putative antibacterial potency is therefore of major importance...
2017: PloS One
https://www.readbyqxmd.com/read/28296418/quantum-yield-measurements-of-fluorophores-in-lipid-bilayers-using-a-plasmonic-nanocavity
#12
Falk Schneider, Daja Ruhlandt, Ingo Gregor, Jörg Enderlein, Alexey I Chizhik
Precise knowledge of the quantum yield is important for many fluorescence-spectroscopic techniques, for example, for Förster resonance energy transfer. However, to measure it for emitters in a complex environment and at low concentrations is far from being trivial. Using a plasmonic nanocavity, we measure the absolute quantum yield value of lipid-conjugated dyes incorporated into a supported lipid bilayer. We show that for both hydrophobic and hydrophilic molecules the quantum yield of dyes inside the lipid bilayer strongly differs from its value in aqueous solution...
March 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28295414/temporal-stability-of-heavy-drinking-days-and-drinking-reductions-among-heavy-drinkers-in-the-combine-study
#13
Katie Witkiewitz, Adam D Wilson, Matthew R Pearson, Kevin A Hallgren, Daniel E Falk, Raye Z Litten, Henry R Kranzler, Karl F Mann, Deborah S Hasin, Stephanie S O'Malley, Raymond F Anton
BACKGROUND: Recently, the Food and Drug Administration (FDA) proposed to expand the options for primary endpoints in the development of medications for alcohol use disorder (AUD) to include either abstinence from alcohol or a non-abstinent outcome: no heavy drinking days (with a heavy drinking day defined as more than 3 drinks per day for women and more than 4 drinks per day for men [>3/>4 cutoff]). The FDA also suggested that 6 months would be the most appropriate length for a clinical trial to demonstrate the stability of this non-abstinent drinking outcome...
March 10, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28293677/the-reliability-and-predictive-validity-of-a-sixth-semester-ospe-in-conservative-dentistry-regarding-performance-on-the-state-examination
#14
Petkov Petko, Katja Knuth-Herzig, Sebastian Hoefer, Sebastian Stehle, Sonja Scherer, Björn Steffen, Stephan Scherzer, Falk Ochsendorf, Holger Horz, Robert Sader, Susanne Gerhardt-Szép
Introduction: The aim of this study was to ascertain whether the testing format of an OSPE (Objective Structured Practical Examination) in conservative dentistry (sixth semester) predicts the scores on the practical section of the state examination (11(th) semester) in the same subject. Taking general student profiles into consideration (score on the school-leaving exam [Abitur], score on the preliminary exam in dental medicine [Physikum], length of university study, cohorts, and sex), we also investigated if any correlations or differences exist in regard to the total and partial scores on the OSPE and the corresponding state examination...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28292666/hierarchical-organization-in-the-temporal-structure-of-infant-direct-speech-and-song
#15
Simone Falk, Christopher T Kello
Caregivers alter the temporal structure of their utterances when talking and singing to infants compared with adult communication. The present study tested whether temporal variability in infant-directed registers serves to emphasize the hierarchical temporal structure of speech. Fifteen German-speaking mothers sang a play song and told a story to their 6-months-old infants, or to an adult. Recordings were analyzed using a recently developed method that determines the degree of nested clustering of temporal events in speech...
March 11, 2017: Cognition
https://www.readbyqxmd.com/read/28292317/the-association-of-funding-source-on-effect-size-in-randomized-controlled-trials-2013-2015-a-cross-sectional-survey-and-meta-analysis
#16
Alberto Falk Delgado, Anna Falk Delgado
BACKGROUND: Trials financed by for-profit organizations have been associated with favorable outcomes of new treatments, although the effect size of funding source impact on outcome is unknown. The aim of this study was to estimate the effect size for a favorable outcome in randomized controlled trials (RCTs), stratified by funding source, that have been published in general medical journals. METHODS: Parallel-group RCTs published in The Lancet, New England Journal of Medicine, and JAMA between 2013 and 2015 were identified...
March 14, 2017: Trials
https://www.readbyqxmd.com/read/28292221/investigation-of-the-usability-of-computerized-critical-care-information-systems-in-germany
#17
Falk von Dincklage, Klaudiusz Suchodolski, Gregor Lichtner, Wolfgang Friesdorf, Beatrice Podtschaske, Maximilian Ragaller
INTRODUCTION: The term "usability" describes how effectively, efficiently, and with what level of user satisfaction an information system can be used to accomplish specific goals. Computerized critical care information systems (CCISs) with high usability increase quality of care and staff satisfaction, while reducing medication errors. Conversely, systems lacking usability can interrupt clinical workflow, facilitate errors, and increase charting time. The aim of this study was to investigate and compare usability across CCIS currently used in Germany...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28291265/t1-weighted-in-vivo-human-whole-brain-mri-dataset-with-an-ultrahigh-isotropic-resolution-of-250-%C3%AE-m
#18
Falk Lüsebrink, Alessandro Sciarra, Hendrik Mattern, Renat Yakupov, Oliver Speck
We present an ultrahigh resolution in vivo human brain magnetic resonance imaging (MRI) dataset. It consists of T1-weighted whole brain anatomical data acquired at 7 Tesla with a nominal isotropic resolution of 250 μm of a single young healthy Caucasian subject and was recorded using prospective motion correction. The raw data amounts to approximately 1.2 TB and was acquired in eight hours total scan time. The resolution of this dataset is far beyond any previously published in vivo structural whole brain dataset...
March 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28290166/long-term-outcome-of-the-sorin-freedom-solo-stentless-aortic-valve
#19
Torsten Christ, Benjamin Claus, Christina Zielinski, Volkmar Falk, Herko Grubitzsch
BACKGROUND: The Sorin Freedom SOLO valve is a third-generation stentless aortic valve which shows beneficial hemodynamic performance compared to stented bioprostheses. Long-term results regarding hemodynamics, the durability of the valve, and patient outcome are scarce, and their acquisition was the aim of this single-center study. METHODS: Between 2005 and 2006, a total of 68 consecutive patients (30 males, 38 females; mean age at surgery 76.1 ± 6.3 years) underwent aortic valve replacement with a Sorin Freedom SOLO prosthesis...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28289700/apolipoproteins-and-their-subspecies-in-human-cerebrospinal-fluid-and-plasma
#20
Manja Koch, Jeremy D Furtado, Kim Falk, Frank Leypoldt, Kenneth J Mukamal, Majken K Jensen
INTRODUCTION: Subspecies of apolipoproteins can be defined by fractionating apolipoproteins based on the presence and absence of coexisting apolipoproteins. METHODS: We determined age- and sex-adjusted correlations of enzyme-linked immunosorbent assay-measured plasma and cerebrospinal fluid (CSF) apolipoproteins (apoA-I, apoC-III, apoE, and apoJ) or apolipoprotein subspecies (apoA-I with and without apoC-III, ApoE, or apoJ; apoE with and without apoC-III or apoJ) in 22 dementia-free participants...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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