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https://www.readbyqxmd.com/read/29044934/aqueous-gold-overgrowth-of-silver-nanoparticles-merging-the-plasmonic-properties-of-silver-with-the-functionality-of-gold
#1
Martin Mayer, Anja Maria Steiner, Falk Röder, Petr Formanek, Tobias König, Andreas Fery
To date, it has not been possible to combine the high optical quality of silver particles with good chemical stability and synthetic convenience in a fully aqueous system, while simultaneously allowing chemical surface functionalization. We present a synthetic pathway for future developments in information, energy and medical technology where strong optical/electronic properties are crucial. Therefore, the advantages inherent to gold are fused with the plasmonic properties of silver in a fully aqueous Au/Ag/Au core-shell-shell system...
October 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29038527/blood-vessel-control-of-macrophage-maturation-promotes-arteriogenesis-in-ischemia
#2
Kashyap Krishnasamy, Anne Limbourg, Tamar Kapanadze, Jaba Gamrekelashvili, Christian Beger, Christine Häger, Vladimir J Lozanovski, Christine S Falk, L Christian Napp, Johann Bauersachs, Matthias Mack, Hermann Haller, Christian Weber, Ralf H Adams, Florian P Limbourg
Ischemia causes an inflammatory response that is intended to restore perfusion and homeostasis yet often aggravates damage. Here we show, using conditional genetic deletion strategies together with adoptive cell transfer experiments in a mouse model of hind limb ischemia, that blood vessels control macrophage differentiation and maturation from recruited monocytes via Notch signaling, which in turn promotes arteriogenesis and tissue repair. Macrophage maturation is controlled by Notch ligand Dll1 expressed in vascular endothelial cells of arteries and requires macrophage canonical Notch signaling via Rbpj, which simultaneously suppresses an inflammatory macrophage fate...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29035078/overrepresentation-of-extreme-events-in-decision-making-reflects-rational-use-of-cognitive-resources
#3
Falk Lieder, Thomas L Griffiths, Ming Hsu
People's decisions and judgments are disproportionately swayed by improbable but extreme eventualities, such as terrorism, that come to mind easily. This article explores whether such availability biases can be reconciled with rational information processing by taking into account the fact that decision makers value their time and have limited cognitive resources. Our analysis suggests that to make optimal use of their finite time decision makers should overrepresent the most important potential consequences relative to less important, put potentially more probable, outcomes...
October 16, 2017: Psychological Review
https://www.readbyqxmd.com/read/29033393/new-bioactive-glass-scaffolds-with-exceptional-qualities-for-bone-tissue-regeneration-response-of-osteoblasts-and-osteoclasts
#4
Tia Kowal, Natalie C Hahn, Stephanie Eider, Jutta Marzillier, Daniella Marie Fodera, Ukrit Thamma, Himanshu Jain, Matthias M Falk
Tissue regeneration is a significantly improved alternative to tissue replacement by implants. It requires porous bioscaffolds for the restoration of natural tissue rather than relying on bio-inactive, often metallic implants. Recently, we developed technology for fabricating novel, nano-macroporous bioactive 'Tailored Amorphous Multi-Porous (TAMP)' hard tissue scaffolds using a 70 mol% SiO2-30 mol% CaO model composition. The TAMP silicate scaffolds, fabricated by a modified sol-gel process, have shown excellent biocompatibility via the rapid formation of hydroxyapatite in biological fluids as well as in early tests with bone forming cells...
October 16, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29032328/effect-of-the-anode-potential-on-the-physiology-and-proteome-of-shewanella-oneidensis-mr-1
#5
Christy Grobbler, Bernardino Virdis, Amanda Nouwens, Falk Harnisch, Korneel Rabaey, Philip L Bond
Shewanella species respire using iron and manganese oxides as well as electrodes as solid terminal electron acceptors. Shewanella oneidenis MR-1 exploits mediated as well as direct extracellular electron transfer (EET) modes to transfer electrons at different formal potentials. These different EET modes at different potentials may utilise alternate electron transfer pathways. Therefore, we investigated how different anode potentials, providing different maximum microbial energy gains impacted S. oneidensis microbial physiology...
October 3, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29032305/physicochemical-pharmacokinetics-as-an-optimization-tool-for-generic-development-a-case-study
#6
Stefan Horkovics-Kovats, Ivan Ulč, Ladislav Vít, Bohdan Němec, Václav Rada
In spite of the fact that dissolution time profiles of 250mg ursodeoxycholic acid (UCDA) capsules developed by Sponsor and 250mg hard capsules produced by Ursofalk®, Dr. Falk Pharma GmbH, indicated similarity (f2=60.6), a bioavailability study indicated unexpected differences in the formulations. To find an explanation of the in vivo performance of the compared formulations, the dissolution profiles were analyzed using a novel dissolution theory considering: The dissolution model was applied to the measured data using SADAPT...
October 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29030974/dopamine-transporter-gene-methylation-is-associated-with-nucleus-accumbens-activation-during-reward-processing-in-healthy-but-not-alcohol-dependent-individuals
#7
Christine Muench, Corinde E Wiers, Carlos R Cortes, Reza Momenan, Falk W Lohoff
BACKGROUND: Alcohol's reinforcement is mediated by dopamine signaling in the ventral striatum, which is modulated by the dopamine transporter (DAT). We hypothesized that methylomic variation in the DAT gene (SLC6A3) affects DAT expression thus contributing to differences in brain reward circuitry in individuals with alcohol dependence (ALC). METHODS: Blood from 45 recently detoxified ALC and 45 healthy control (HC) individuals was used to assess DNA methylation across 5 functional regions of SLC6A3...
October 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29029971/das-stepped-wedge-design-stufenlos-regelbar
#8
EDITORIAL
Juliane Köberlein-Neu, Falk Hoffmann
No abstract text is available yet for this article.
October 10, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29029420/generation-and-evaluation-of-antibody-agents-for-molecular-imaging-of-cd44v6-expressing-cancers
#9
Anna-Karin Haylock, Johan Nilvebrant, Anja Mortensen, Irina Velikyan, Marika Nestor, Ronny Falk
AIM: The aim of this study was to generate and characterize scFv antibodies directed to human CD44v6, as well as to radiolabel and evaluate top candidates in vitro and in vivo for their potential use in CD44v6-targeted molecular imaging in cancer patients. MATERIALS AND METHODS: Phage display selections were used to isolate CD44v6-specific scFvs. A chain shuffling strategy was employed for affinity maturation based on a set of CD44v6-specific first-generation clones...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028338/molecular-hybridization-of-potent-and-selective-%C3%AE-hydroxybutyric-acid-ghb-ligands-design-synthesis-binding-studies-and-molecular-modelling-of-novel-3-hydroxycyclopent-1-enecarboxylic-acid-hocpca-and-trans-%C3%AE-hydroxycrotonic-acid-t-hca-analogs
#10
Jacob Krall, Claus Hatt Jensen, Francesco Bavo, Christina Birkedal Falk-Petersen, Anne Stahr Haugaard, Stine Byskov Vogensen, Yongsong Tian, Mia Nittegaard-Nielsen, Sara Björk Sigurdardóttir, Jan Kehler, Kenneth Thermann Kongstad, David E Gloriam, Rasmus Prætorius Clausen, Kasper Harpsøe, Petrine Wellendorph, Bente Frølund
γ-hydroxybutyric acid (GHB) is a neuroactive substance with specific high-affinity binding sites. To facilitate target identification and ligand optimization, we herein report a comprehensive structure-affinity relationship study for novel ligands targeting these binding sites. A molecular hybridization strategy was used based on the conformationally restricted 3-hydroxycyclopent-1-enecarboxylic acid (HOCPCA) and the linear GHB analog, trans-4-hydroxycrotonic acid (T-HCA). In general, all structural modifications performed on HOCPCA led to reduced affinity...
October 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29023941/mechanical-ventilation-for-duchenne-muscular-dystrophy-sinner-or-saint
#11
EDITORIAL
Barbara K Smith, Darin J Falk
No abstract text is available yet for this article.
October 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29023846/locomotor-and-skeletal-muscle-abnormalities-in-trembler-j-neuropathic-mice
#12
Darin J Falk, Tori Galatas, Adrian G Todd, Elliott P Soto, Andrew B Harris, Lucia Notterpek
INTRODUCTION: Patients with hereditary peripheral neuropathies exhibit characteristic deformities of the hands and feet and have difficulty ambulating. To examine to what extent neuropathic animals recapitulate these deficits, we studied Trembler J mice, which model early-onset demyelinating neuropathy. METHODS: A cohort of 4-month old female wild type and neuropathic mice were evaluated for locomotor measurements, neuromuscular function and skeletal muscle proteolysis and morphometry...
October 12, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29023707/guidelines-for-the-use-of-flow-cytometry-and-cell-sorting-in-immunological-studies
#13
Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E Boulais, Ryan R Brinkman, Martin Büscher, Dirk H Busch, Timothy P Bushnell, Xuetao Cao, Andrea Cavani, Pratip K Chattopadhyay, Qingyu Cheng, Sue Chow, Mario Clerici, Anne Cooke, Antonio Cosma, Lorenzo Cosmi, Ana Cumano, Van Duc Dang, Derek Davies, Sara De Biasi, Genny Del Zotto, Silvia Della Bella, Paolo Dellabona, Günnur Deniz, Mark Dessing, Andreas Diefenbach, James Di Santo, Francesco Dieli, Andreas Dolf, Vera S Donnenberg, Thomas Dörner, Götz R A Ehrhardt, Elmar Endl, Pablo Engel, Britta Engelhardt, Charlotte Esser, Bart Everts, Christine S Falk, Todd A Fehniger, Andrew Filby, Simon Fillatreau, Marie Follo, Irmgard Förster, John Foster, Gemma A Foulds, Paul S Frenette, David Galbraith, Natalio Garbi, Maria Dolores García-Godoy, Kamran Ghoreschi, Lara Gibellini, Christoph Goettlinger, Carl S Goodyear, Andrea Gori, Jane Grogan, Mor Gross, Andreas Grützkau, Daryl Grummitt, Jonas Hahn, Quirin Hammer, Anja E Hauser, David L Haviland, David Hedley, Guadalupe Herrera, Martin Herrmann, Falk Hiepe, Tristan Holland, Pleun Hombrink, Jessica P Houston, Bimba F Hoyer, Bo Huang, Christopher A Hunter, Anna Iannone, Hans-Martin Jäck, Beatriz Jávega, Stipan Jonjic, Kerstin Juelke, Steffen Jung, Toralf Kaiser, Tomas Kalina, Baerbel Keller, Srijit Khan, Deborah Kienhöfer, Thomas Kroneis, Désirée Kunkel, Christian Kurts, Pia Kvistborg, Joanne Lannigan, Olivier Lantz, Anis Larbi, Salome LeibundGut-Landmann, Michael D Leipold, Megan K Levings, Virginia Litwin, Yanling Liu, Michael Lohoff, Giovanna Lombardi, Lilly Lopez, Amy Lovett-Racke, Erik Lubberts, Burkhard Ludewig, Enrico Lugli, Holden T Maecker, Glòria Martrus, Giuseppe Matarese, Christian Maueröder, Mairi McGrath, Iain McInnes, Henrik E Mei, Fritz Melchers, Susanne Melzer, Dirk Mielenz, Kingston Mills, Jenny Mjösberg, Jonni Moore, Barry Moran, Alessandro Moretta, Lorenzo Moretta, Tim R Mosmann, Susann Müller, Werner Müller, Christian Münz, Gabriele Multhoff, Luis Enrique Munoz, Kenneth M Murphy, Toshinori Nakayama, Milena Nasi, Christine Neudörfl, John Nolan, Sussan Nourshargh, José-Enrique O'Connor, Wenjun Ouyang, Annette Oxenius, Raghav Palankar, Isabel Panse, Pärt Peterson, Christian Peth, Jordi Petriz, Daisy Philips, Winfried Pickl, Silvia Piconese, Marcello Pinti, A Graham Pockley, Malgorzata Justyna Podolska, Carlo Pucillo, Sally A Quataert, Timothy R D J Radstake, Bartek Rajwa, Jonathan A Rebhahn, Diether Recktenwald, Ester B M Remmerswaal, Katy Rezvani, Laura G Rico, J Paul Robinson, Chiara Romagnani, Anna Rubartelli, Jürgen Ruland, Shimon Sakaguchi, Francisco Sala-de-Oyanguren, Yvonne Samstag, Sharon Sanderson, Birgit Sawitzki, Alexander Scheffold, Matthias Schiemann, Frank Schildberg, Esther Schimisky, Stephan A Schmid, Steffen Schmitt, Kilian Schober, Thomas Schüler, Axel Ronald Schulz, Ton Schumacher, Cristiano Scotta, T Vincent Shankey, Anat Shemer, Anna-Katharina Simon, Josef Spidlen, Alan M Stall, Regina Stark, Christina Stehle, Merle Stein, Tobit Steinmetz, Hannes Stockinger, Yousuke Takahama, Attila Tarnok, ZhiGang Tian, Gergely Toldi, Julia Tornack, Elisabetta Traggiai, Joe Trotter, Henning Ulrich, Marlous van der Braber, René A W van Lier, Marcello Veldhoen, Salvador Vento-Asturias, Paulo Vieira, David Voehringer, Hans-Dieter Volk, Konrad von Volkmann, Ari Waisman, Rachael Walker, Michael D Ward, Klaus Warnatz, Sarah Warth, James V Watson, Carsten Watzl, Leonie Wegener, Annika Wiedemann, Jürgen Wienands, Gerald Willimsky, James Wing, Peter Wurst, Liping Yu, Alice Yue, Qianjun Zhang, Yi Zhao, Susanne Ziegler, Jakob Zimmermann
No abstract text is available yet for this article.
October 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29022841/designing-cellulosic-and-nanocellulosic-sensors-for-interface-with-a-protease-sequestrant-wound-dressing-prototype-implications-of-material-selection-for-dressing-and-protease-sensor-design
#14
Krystal R Fontenot, J Vincent Edwards, David Haldane, Nicole Pircher, Falk Liebner, Brian D Condon, Huzaifah Qureshi, Dorne Yager
Interfacing nanocellulosic-based biosensors with chronic wound dressings for protease point of care diagnostics combines functional material properties of high specific surface area, appropriate surface charge, and hydrophilicity with biocompatibility to the wound environment. Combining a protease sensor with a dressing is consistent with the concept of an intelligent dressing, which has been a goal of wound-dressing design for more than a quarter century. We present here biosensors with a nanocellulosic transducer surface (nanocrystals, nanocellulose composites, and nanocellulosic aerogels) immobilized with a fluorescent elastase tripeptide or tetrapeptide biomolecule, which has selectivity and affinity for human neutrophil elastase present in chronic wound fluid...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29021801/inspirations-on-virus-replication-and-cell-to-cell-movement-from-studies-examining-the-cytopathology-induced-by-lettuce-infectious-yellows-virus-in-plant-cells
#15
REVIEW
Wenjie Qiao, Vicente Medina, Bryce W Falk
Lettuce infectious yellows virus (LIYV) is the type member of the genus Crinivirus in the family Closteroviridae. Like many other positive-strand RNA viruses, LIYV infections induce a number of cytopathic changes in plant cells, of which the two most characteristic are: Beet yellows virus-type inclusion bodies composed of vesicles derived from cytoplasmic membranes; and conical plasmalemma deposits (PLDs) located at the plasmalemma over plasmodesmata pit fields. The former are not only found in various closterovirus infections, but similar structures are known as 'viral factories' or viroplasms in cells infected with diverse types of animal and plant viruses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29021339/phosphorylation-regulates-connexin43-zo-1-binding-and-release-an-important-step-in-gap-junction-turnover
#16
Anastasia F Thévenin, Rachel A Margraf, Charles G Fisher, Rachael M Kells-Andrews, Matthias M Falk
To investigate whether connexin phosphorylation regulates ZO-1's known role in gap junction (GJ) function, we generated and analyzed a series of phosphomimetic and phosphorylation-dead mutants by exchanging known conserved regulatory serine (S) residues 255, 279/282, 365, 368, and 373 located in the C-terminal domain of connexin43 (Cx43) into glutamic acid (E) or alanine (A) residues. All connexin mutants were translated into stable, full-length proteins and assembled into GJs when expressed in HeLa or MDCK cells...
October 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29019001/anaplastic-thyroid-cancer-and-hyperfractionated-accelerated-radiotherapy-hart-with-and-without-surgery
#17
Anne-Birgitte Jacobsen, Krystyna K Grøholt, Bianca Lorntzsen, Terje A Osnes, Ragnhild Sørum Falk, Eva Sigstad
Anaplastic carcinoma of the thyroid gland (ATC) is one of the most aggressive cancers in humans. With insufficient treatment, the disease most often leads to death in suffocation. From 2002, our treatment strategy has been hyperfractionated accelerated radiotherapy (HART) with high doses (64 Gy) to the neck, followed by surgery 4-8 weeks later if feasible, with the aim to gain control in the neck. After a pathology review, 51 patients were diagnosed with ATC in the period 2002-2014 in the south-east of Norway...
October 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29018835/-13-c-31-p-mrs-metabolic-biomarkers-of-disease-progression-and-response-to-aav-delivery-of-hgaa-in-a-mouse-model-of-pompe-disease
#18
Celine Baligand, Adrian G Todd, Brittany Lee-McMullen, Ravneet S Vohra, Barry J Byrne, Darin J Falk, Glenn A Walter
The development of therapeutic clinical trials for glycogen storage disorders, including Pompe disease, has called for non-invasive and objective biomarkers. Glycogen accumulation can be measured in vivo with (13)C MRS. However, clinical implementation remains challenging due to low signal-to-noise. On the other hand, the buildup of glycolytic intermediates may be detected with (31)P MRS. We sought to identify new biomarkers of disease progression in muscle using (13)C/(31)P MRS and (1)H HR-MAS in a mouse model of Pompe disease (Gaa(-/-))...
December 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29016813/epicardial-left-atrial-appendage-atriclip-occlusion-reduces-the-incidence-of-stroke-in-patients-with-atrial-fibrillation-undergoing-cardiac-surgery
#19
Etem Caliskan, Ayhan Sahin, Murat Yilmaz, Burkhardt Seifert, Ricarda Hinzpeter, Hatem Alkadhi, James L Cox, Tomas Holubec, Diana Reser, Volkmar Falk, Jürg Grünenfelder, Michele Genoni, Francesco Maisano, Sacha P Salzberg, Maximilian Y Emmert
Aims: Left atrial appendage (LAA) occlusion has emerged as an interesting alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). We report the safety, efficacy, and durability of concomitant device-enabled epicardial LAA occlusion during open-heart surgery. In addition to long-term follow-up, we evaluate the impact on stroke risk in this selected population. Methods and results: A total of 291 AtriClip devices were deployed epicardially in patients (mean CHA2DS2-VASc-Score: 3...
July 18, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016312/dengue-virus-serotype-2-established-in-northern-mozambique-2015-2016
#20
John Oludele, Birgitta Lesko, Isabel Mahumane Gundane, Fernanda de Bruycker-Nogueira, Argentina Muianga, Sadia Ali, Flora Mula, Imelda Chelene, Kerstin I Falk, Flávia Barreto Dos Santos, Eduardo Samo Gudo
After the report of an outbreak of dengue virus serotype 2 in 2014 in Nampula and Pemba cities, northern Mozambique, a surveillance system was established by the National Institute of Health. A study was performed during 2015-2016 to monitor the trend of the outbreak and confirm the circulating serotype of dengue virus (DENV). After the inclusion of consenting patients who met the case definition, samples from 192 patients were tested for the presence of nonstructural protein 1 antigen, and 60/192 (31%) samples were positive...
September 18, 2017: American Journal of Tropical Medicine and Hygiene
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