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Emanuele Barca, Rebecca D Ganetzky, Prasanth Potluri, Marti Juanola-Falgarona, Xiaowu Gai, Dong Li, Chaim Jalas, Yoel Hirsch, Valentina Emmanuele, Saba Tadesse, Marcello Ziosi, Hasan O Akman, Wendy K Chung, Kurenai Tanji, Elizabeth McCormick, Emily Place, Mark Consugar, Eric A Pierce, Hakon Hakonarson, Douglas C Wallace, Michio Hirano, Marni J Falk
Leigh syndrome is a frequent, heterogeneous pediatric presentation of mitochondrial oxidative phosphorylation (OXPHOS) disease, manifesting with psychomotor retardation and necrotizing lesions in brain deep gray matter. OXPHOS occurs at the inner mitochondrial membrane through the integrated activity of 5 protein complexes, of which complex V (CV) functions in a dimeric form to directly generate adenosine triphosphate (ATP). Mutations in several different structural CV subunits cause Leigh syndrome; however, dimerization defects have not been associated with human disease...
June 18, 2018: Human Molecular Genetics
Marisa Karow, J Gray Camp, Sven Falk, Tobias Gerber, Abhijeet Pataskar, Malgorzata Gac-Santel, Jorge Kageyama, Agnieska Brazovskaja, Angela Garding, Wenqiang Fan, Therese Riedemann, Antonella Casamassa, Andrej Smiyakin, Christian Schichor, Magdalena Götz, Vijay K Tiwari, Barbara Treutlein, Benedikt Berninger
Ectopic expression of defined transcription factors can force direct cell-fate conversion from one lineage to another in the absence of cell division. Several transcription factor cocktails have enabled successful reprogramming of various somatic cell types into induced neurons (iNs) of distinct neurotransmitter phenotype. However, the nature of the intermediate states that drive the reprogramming trajectory toward distinct iN types is largely unknown. Here we show that successful direct reprogramming of adult human brain pericytes into functional iNs by Ascl1 and Sox2 encompasses transient activation of a neural stem cell-like gene expression program that precedes bifurcation into distinct neuronal lineages...
June 18, 2018: Nature Neuroscience
Falk Kiefer
No abstract text is available yet for this article.
June 18, 2018: European Addiction Research
Felix Dondorf, Frank Uteβ, René Fahrner, Philipp Felgendreff, Michael Ardelt, Hans-Michael Tautenhahn, Utz Settmacher, Falk Rauchfuβ
OBJECTIVES: Perihilar cholangiocarcinoma (Klatskin tumor) is a rare tumor entity, which is diagnosed late due to uncharacteristic symptoms. The therapeutic strategy for cure is still liver resection. Liver transplant in cases of locally irresectable tumors represents an alternative potential curative therapy for a select group of patients. MATERIALS AND METHODS: We present our data of 22 patients with irresectable Klatskin tumors who received transplants between 1996 and 2015...
June 18, 2018: Experimental and Clinical Transplantation
Hanna Wolling, Sarah A Konze, Anne Höfer, Jelena Erdmann, Andreas Pich, Robert Zweigerdt, Falk F R Buettner
Human pluripotent stem cells (hPSCs) can be differentiated in vitro into cardiomyocytes (CMs) but the molecular mechanisms behind this process are still not fully understood. In particular identification of morphogens remained elusive because the mass spectrometry (MS)-based identification of secreted proteins from cell culture supernatants is impeded by high levels of albumin present in common differentiation media. Thus we established an albumin-free cardiomyogenic differentiation medium and performed secretomics at seven different time points during in vitro differentiation...
June 14, 2018: Proteomics
Diane Brentari, Joshua Falk, Anastasia Giannakidou, Annika Herrmann, Elisabeth Volk, Markus Steinbach
In signed and spoken language sentences, imperative mood and the corresponding speech acts such as for instance, command, permission or advice, can be distinguished by morphosyntactic structures, but also solely by prosodic cues, which are the focus of this paper. These cues can express paralinguistic mental states or grammatical meaning, and we show that in American Sign Language (ASL), they also exhibit the function, scope, and alignment of prosodic, linguistic elements of sign languages. The production and comprehension of prosodic facial expressions and temporal patterns therefore can shed light on how cues are grammaticalized in sign languages...
2018: Frontiers in Psychology
Gal Schkolnik, Matthias Schmidt, Marco G Mazza, Falk Harnisch, Niculina Musat
[This corrects the article DOI: 10.1371/journal.pone.0145871.].
2018: PloS One
Patrick Bach, Anne Koopmann, Derik Hermann, Falk Kiefer, Jan Malte Bumb
No abstract text is available yet for this article.
June 12, 2018: Journal of Clinical Psychopharmacology
Jerome C Foo, Fabian Streit, Jens Treutlein, Stephan Ripke, Stephanie H Witt, Jana Strohmaier, Franziska Degenhardt, Andreas J Forstner, Per Hoffmann, Michael Soyka, Norbert Dahmen, Norbert Scherbaum, Norbert Wodarz, Stefanie Heilmann-Heimbach, Stefan Herms, Sven Cichon, Ulrich Preuss, Wolfgang Gaebel, Monika Ridinger, Sabine Hoffmann, Thomas G Schulze, Wolfgang Maier, Peter Zill, Bertram Müller-Myhsok, Marcus Ising, Susanne Lucae, Markus M Nöthen, Karl Mann, Falk Kiefer, Marcella Rietschel, Josef Frank
The clinical comorbidity of alcohol dependence (AD) and major depressive disorder (MDD) is well established, whereas genetic factors influencing co-occurrence remain unclear. A recent study using polygenic risk scores (PRS) calculated based on the first-wave Psychiatric Genomics Consortium MDD meta-analysis (PGC-MDD1) suggests a modest shared genetic contribution to MDD and AD. Using a (∼10 fold) larger discovery sample, we calculated PRS based on the second wave (PGC-MDD2) of results, in a severe AD case-control target sample...
June 12, 2018: Psychiatric Genetics
Stephen Jia Wang, Björn Sommer, Wenlong Cheng, Falk Schreiber
Back pain is a serious medical problem especially for those people sitting over long periods during their daily work. Here we present a system to help users monitoring and examining their sitting behavior. The Virtual-Spine Platform (VSP) is an integrated system consisting of a real-time body position monitoring module and a data visualization module to provide individualized, immediate, and accurate sitting behavior support. It provides a comprehensive spine movement analysis as well as accumulated data visualization to demonstrate behavior patterns within a certain period...
2018: PloS One
Simone Salzer, Annette Stefini, Klaus-Thomas Kronmüller, Eric Leibing, Falk Leichsenring, Peter Henningsen, Hamid Peseschkian, Günter Reich, Rita Rosner, Uwe Ruhl, Yvonne Schopf, Christiane Steinert, Eva Vonderlin, Regina Steil
BACKGROUND: Although social anxiety disorder (SAD) has an early onset and is frequently found in adolescence, evidence for psychotherapeutic treatments of SAD in adolescents is rather scarce. Within the Social Phobia Psychotherapy Research Network (SOPHO-NET), we examined the efficacy of cognitive-behavioral (CBT) and psychodynamic therapy (PDT) compared to a waiting list (WL) in these patients. METHODS: In a multicenter randomized controlled superiority trial, 107 patients, aged 14-20 years, were randomized to CBT (n = 34), PDT (n = 34), or WL (n = 39)...
June 12, 2018: Psychotherapy and Psychosomatics
Falk Schneider, Dominic Waithe, Silvia Galiani, Jorge Bernardino de la Serna, Erdinc Sezgin, Christian Eggeling
The diffusion dynamics in the cellular plasma membrane provide crucial insights into molecular interactions, organization and bioactivity. Beam-scanning fluorescence correlation spectroscopy combined with super-resolution stimulated emission depletion nanoscopy (scanning STED-FCS) measures such dynamics with high spatial and temporal resolution. It reveals nanoscale diffusion characteristics by measuring the molecular diffusion in conventional confocal mode and super-resolved STED mode sequentially for each pixel along the scanned line...
June 12, 2018: Nano Letters
Lutz Schmitz, Schapoor Hessam, Lisa Scholl, Sarah Reitenbach, Marc Hanno Segert, Thilo Gambichler, Eggert Stockfleth, Falk Georges Bechara
Actinic keratoses (AKs) can progress into invasive squamous cell carcinoma and thus may become a life threatening disease. Argon plasma coagulation (APC) might complement the therapeutic armamentarium in particular for AK lesions. However, there is no data on APC induced micromorphological changes following the treatment of AKs. We aimed to determine in-vivo APC induced effects on the epidermis and dermo-epidermal junction zone (DEJ) in AK lesions. We performed APC in 108 AKs using the spray mode with a power setting of 15W and a flow rate of 2...
June 12, 2018: Journal of Biophotonics
C Berger, N Boggavarapu, E Norlin, S Queckbörner, K Hörnaeus, A Falk, M Engman, M Ramström, P G L Lalitkumar, K Gemzell-Danielsson
OBJECTIVE: The progesterone receptor modulator (PRM) Mifepristone hold the potential to be developed for regular contraception. However, long-term treatment can cause thickening of the endometrium and PRM associated endometrial changes (PAEC). The objective of this study was to explore the molecular expression of endometrium displaying PAEC after mifepristone treatment, in order to understand the future implications of PAEC and safety of long-term use. STUDY DESIGN: Endometrial biopsies were obtained from pre-menopausal women following three months of continuous mifepristone treatment...
June 8, 2018: Contraception
Gunnar Lewon Lutterkort, Anika Wranke, Julia Hengst, Cihan Yurdaydin, Judith Stift, Birgit Bremer, Svenja Hardtke, Onur Keskin, Ramazan Idilman, Michael P Manns, Hans Peter Dienes, Christine Falk, Heiner Wedemeyer, Benjamin Heidrich
Chronic hepatitis D is caused by coinfection of hepatitis B and hepatitis D virus. While HDV is the dominant virus over HBV in the majority of cases, mechanisms and consequences of viral dominances are largely unknown. We aimed to investigate associations between viral dominance patterns and patients' characteristics and inflammatory features. 109 HDV patients treated with PEG-IFNa-2a within the international multicentre, prospective HIDIT-2 trial were studied. Patients were classified as D- or B-dominant if the viral load of one virus exceeded that of the other virus by more than 1log10 ...
June 11, 2018: Journal of Viral Hepatitis
Marianne Hollensteiner, Michael Malek, Peter Augat, David Fürst, Falk Schrödl, Stefan Hunger, Benjamin Esterer, Stefan Gabauer, Andreas Schrempf
PURPOSE: Surgical skills can be improved through practical exercise. The use of specimens, human as well as animal, or live animals for surgical training is limited due to ethical concerns. Drawbacks of simulators are costs, fidelity and creditibility. Thus, simulators must be evaluated objectively to determine their validity before they can be used as teaching modalities. The aim of this study was to verify the face content and construct validity of a novel model-based simulator for lifting tabula externa transplants from the parietal skull...
May 21, 2018: Journal of Cranio-maxillo-facial Surgery
Falk Schwendicke, Karim Elhennawy, Osama El Shahawy, Reham Maher, Thais Gimenez, Fausto M Mendes, Brian H Willis
BACKGROUND: Diagnostic meta-analyses on caries detection methods should assist practitioners in their daily practice. However, conventional meta-analysis estimates may be inapplicable due to differences in test conduct, applied thresholds and assessed population between settings. Our aim was to demonstrate the impact of tailored meta-analysis of visual and radiographic caries detection to different settings using setting-specific routine data. METHODS: Published systematic reviews and meta-analyses on the accuracy of visual and radiographic caries detection were used...
June 8, 2018: BMC Oral Health
Ting-Kuo Huang, Bryce W Falk, Abhaya M Dandekar, Karen A McDonald
We have previously demonstrated that the inducible plant viral vector (CMViva) in transgenic plant cell cultures can significantly improve the productivity of extracellular functional recombinant human alpha-1-antiryspin (rAAT) compared with either a common plant constitutive promoter ( Cauliflower mosaic virus (CaMV) 35S) or a chemically inducible promoter (estrogen receptor-based XVE) system. For a transgenic plant host system, however, viral or transgene-induced post-transcriptional gene silencing (PTGS) has been identified as a host response mechanism that may dramatically reduce the expression of a foreign gene...
May 24, 2018: International Journal of Molecular Sciences
Michael Dörks, Stefan Herget-Rosenthal, Falk Hoffmann, Kathrin Jobski
Background/aims: In 2012, the European Medicines Agency reviewed the safety of dual renin-angiotensin system (RAS) blockade because of potentially increased risks for inter alia acute kidney injury (AKI). Since residents of nursing homes are particularly vulnerable to adverse drug outcomes, the aims of our study were to describe RAS-inhibiting drug use in German nursing home residents and examine the risk of AKI associated with dual RAS blockade. Methods: Based on claims data, a nested case-control study within a cohort of RAS-inhibiting drug users was conducted...
2018: Clinical Interventions in Aging
Alberto Falk Delgado, Francesca De Luca, Danielle van Westen, Anna Falk Delgado
Background: Arterial spin labeling is an MR imaging technique that measures cerebral blood flow (CBF) non-invasively. The aim of the study is to assess the diagnostic performance of Arterial spin labeling (ASL) MR imaging for differentiation between high-grade glioma and low-grade glioma. Methods: Cochrane Library, Embase, Medline and Web of Science Core Collection were searched. Study selection until November 2017. This study was prospectively registered in Prospero (CRD42017080885)...
June 2, 2018: Neuro-oncology
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