Julian Wenzel, Shalaila S Haas, Dominic B Dwyer, Anne Ruef, Oemer Faruk Oeztuerk, Linda A Antonucci, Sebastian von Saldern, Carolina Bonivento, Marco Garzitto, Adele Ferro, Marco Paolini, Janusch Blautzik, Stefan Borgwardt, Paolo Brambilla, Eva Meisenzahl, Raimo K R Salokangas, Rachel Upthegrove, Stephen J Wood, Joseph Kambeitz, Nikolaos Koutsouleris, Lana Kambeitz-Ilankovic
In schizophrenia, neurocognitive subtypes can be distinguished based on cognitive performance and they are associated with neuroanatomical alterations. We investigated the existence of cognitive subtypes in shortly medicated recent onset psychosis patients, their underlying gray matter volume patterns and clinical characteristics. We used a K-means algorithm to cluster 108 psychosis patients from the multi-site EU PRONIA (Prognostic tools for early psychosis management) study based on cognitive performance and validated the solution independently (N = 53)...
March 15, 2021: Neuropsychopharmacology